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... he was tired as McEnroe wins, Motor racing FOCA unmoved by later date of Argentine GP, For ...
1980 - Gale Group | TDA
Bernhard Suppmann, R. Gary Sawers,
... was located in the identical position in the focA ( for mate c hannel; previously termed orf ) gene ... pfl operon in both mutants. A defined chromosomal focA nonsense mutant, which showed minimal polarity effects on ... changes in the intracellular formate concentration in a focA mutant indicated that the level of formate inside ... in the amount of formate excreted by a focA mutant into the culture medium. Taken together, these ... anaerobic ceils which do not have a functional focA gene product and that one function of FocA ...
Tópico(s): DNA and Nucleic Acid Chemistry
1994 - Wiley | Molecular Microbiology
From Ian Murray, From Our Correspondent, By Hugh Noyes Parliamentary Correspondent, By Philip Robinson Financial Staff, By Paul Routledge Labour Editor, By Kenneth Gosling, By Donald Macintyre Labour Reporter, By John Witherow, By Frances Gibb, From Ronald Kershaw, By Our Political Staff, By Peter Waymark, By Our Political Editor, By Fred Emery Political Editor, By Richard Ford, By Martin Huckerby Music Reporter, From John Young Planning Reporter, From Tim Jones, By Christopher Warman Local Government Correspondent, By Lucy Hodges, By Stewart Tendler Crime Reporter, By Pat Healy Social Services Correspondent, By Diana Geddes Education Correspondent, From a Staff Reporter, By Martin Huckerby Theatre Reporter, From John Earle, From Richard Wigg, From Harry Debelius, From Charles Hargrove, From Robert Fisk, From Our Own Correspondent, By Ronald Kershaw Northern Industrial Correspondent, From Frank Vogl US Economics Correspondent, By David Spanier Diplomatic Correspondent, By Frances Williams, From Michael Hornsby, By Roman Eisenstein Banking Correspondent, From Nicholas Ashford, From Moshe Brilliant, From Michael Binyon, Elizabeth Roe, Knox Russell, Michael Church, Richard Williams, Joan Chissell, William Mann, Stanley Sadie, A. L. Rowse, Irving Wardle, Ned Chaillet, Hilary Finch, By John Blunsden, From Dilip Rao, By Steve Elliott, By Srikumar Sen Boxing Correspondent, By Gordon Allan, By Keith Macklin, By Michael Phillips Racing Correspondent, By Sydney Friskin, Michael Binyon, Alan Hamilton, Marcel Berlins Legal Correspondent, Bernard Levin, DENIS MAHON, , JOHN LOUGH, , LESLIE MURPHY, , ROGER PINCHAM, , T. J. HARRIS, , ERNEST PENDROUS, , ANTHONY MORTIMER, , LUDOVIC KENNEDY, , CHRISTOPHER DRIVER, , MARGARET DRIVER, , GRAHAM SMALLBONE, , D. G. IVES, , M. BARROW, , JAMES GOLDSMITH, , P. J. FOWLER, , JOHN BARRAN, , By the staff of Nature, By Huon Mallalieu, By Our Theatre Reporter, By Our Music Reporter, J. O'C. writes:, By Peter Hill Industrial Editor, By John Huxley and Bill Johnstone, Kenneth Owen, By Peter Wilson-Smith, By Ronald Pullen, By Our Technology Editor, By David Blake Economics Editor, By Clifford Webb Midland Industrial Correspondent, By David Spanier, From Frank Vogl United States Economics Correspondent, Edward Townsend, By Our Financial Staff, By John Huxley, By Peter Hill, Bill Johnstone, A. F. D. FERGUSON, , L. GEORGHIOU, , JOHN NEWMAN, , A. G. W. SCOTT, , EDWARD A. KALFAYAN, , H. PETER VOGEL, , IRVING STONE, , BY THE FINANCIAL EDITOR, Ross Davies, Christopher Follett, Robin Young, By Catherine Gunn, Margareta Pagano, By Rosemary Unsworth, By Margareta Pagano, Baron Phillips, Michael Horsnell, Edited by Peter Davalle,
... Breakthrough in dispute heralds peace between FISA and FOCA, Benevolent gnome with steel in his eyes, Rugby ...
1981 - Gale Group | TDA
Lydia Beyer, Claudia Doberenz, Dörte Falke, Doreen Hunger, Bernhard Suppmann, R. Gary Sawers,
... the other is in the cytoplasm. The bidirectional FocA channel translocates formate across the membrane delivering substrate to these FDHs. FocA synthesis is tightly coupled to synthesis of pyruvate ... consequences on the fermentation product spectrum of altering FocA levels, uncoupling FocA from PflB synthesis or blocking formate metabolism. Changing the focA translation initiation codon from GUG to AUG resulted in a 20-fold increase in FocA during fermentation and an ∼3-fold increase in ... in the growth medium only in mutants lacking FocA, despite retaining active PflB, or when formate could ...
Tópico(s): Enzyme Structure and Function
2013 - American Society for Microbiology | Journal of Bacteriology
Claudia Doberenz, Michael Zorn, Dörte Falke, D.P. Nannemann, Doreen Hunger, Lydia Beyer, Christian Ihling, Jens Meiler, Andrea Sinz, R. Gary Sawers,
... channels that translocate monovalent anions across biological membranes. FocA (formate channel A) translocates formate bidirectionally but the ... in enterobacteria and other microbes, interacts specifically with FocA. Association of PflB with the cytoplasmic membrane was shown to be FocA dependent and purified, Strep-tagged FocA specifically retrieved PflB from Escherichia coli crude extracts. ... could be shown that the N-terminus of FocA and the central domain of PflB were involved ... for the first time a model for the FocA-PflB complex. The model suggests that the N- ...
Tópico(s): Ion Transport and Channel Regulation
2014 - Elsevier BV | Journal of Molecular Biology
Michelle Kammel, Constanze Pinske, R. Gary Sawers,
... cytoplasmic membrane is controlled by the formate channel, FocA, a member of the formate-nitrite transporter (FNT) ... highlights recent advances in our understanding of how FocA helps to maintain intracellular formate and pH homeostasis ... formate/formic acid are distinct processes performed by FocA and both are controlled through protein interaction between FocA's N-terminal domain with PflB. Formic acid efflux by FocA helps to maintain cytoplasmic pH balance during exponential- ... complex, whose synthesis also depends on formate. Thus, FocA, FHL and PflB function together to govern formate ...
Tópico(s): Ion Transport and Channel Regulation
2022 - Microbiology Society | Microbiology
Zhiwei Feng, Tingjun Hou, Youyong Li,
FocA, a member of the formate-nitrite transporter (FNT) family, transports formate and nitrite across biological membranes ... of formate in bacteria are both mediated by FocA, which undergoes a pH-dependent functional switch. Recently, the crystal structures of Escherichia coli FocA (EcFocA), Vibrio cholerae FocA (VcFocA), and Salmonella typhimurium FocA (StFocA) were reported. We performed molecular dynamics (MD) ... protonated and unprotonated), representing different pH conditions of FocA. The N-terminal helix in each protomer of ...
Tópico(s): Drug Transport and Resistance Mechanisms
2012 - American Chemical Society | Journal of Chemical Information and Modeling
Ilaria Campesi, Manuela Sanna, Angelo Zinellu, Ciriaco Carru, Laura Rubattu, Pamela Bulzomi, Giuseppe Seghieri, Giancarlo Tonolo, Mario Palermo, Giuseppe Rosano, Maria Marino, Flavia Franconi,
... were further stratified as a function of androgenic (FOCA+) and non-androgenic (FOCA-) properties of progestins. Routine hematological, biochemical, inflammatory and ... high-density lipoprotein and calcium were higher in FOCA- than in FOCA+, whereas percentage oxygen saturation and γ-glutamyl transpeptidase were lower in FOCA- than in FOCA+. Importantly, FOCs had a lower global DNA methylation, ... increased estrogen receptor α expression, more considerably in FOCA+, and decreased estrogen receptor β, more considerably in ...
Tópico(s): Pregnancy and Medication Impact
2012 - BioMed Central | Biology of Sex Differences
Shuai Ma, Sisi Jiang, Rui Peng, Qiong Zhu, Hongbin Sun, Jianfu Li, Xiaoyan Jia, Ilan Goldberg, Liang Yu, Cheng Luo,
... FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) metric was used to analyze the spontaneous activity in whole brain. The FOCA difference between two groups were detected using a two sample t-test analysis. Correlations between the FOCA values and features of seizures were analyzed. The ... this study showed that patients had significantly increased FOCA in motor-related cortex regions, including bilateral supplementary ... ganglia, as well as a substantial reduction of FOCA in regions of default mode network (DMN) and ...
Tópico(s): Neural dynamics and brain function
2017 - Frontiers Media | Frontiers in Computational Neuroscience
Mansour Abolghasemian, Sebastián León, Paul T. H. Lee, Oleg Safir, David Backstein, Allan E. Gross, Paul R.T. Kuzyk,
Background: The use of fresh osteochondral allograft (FOCA) transplantation is a treatment option for large posttraumatic tibial osteochondral defects in young, high-demand patients. We aimed to assess the long-term ... depth who were treated with use of a FOCA, with or without a realignment osteotomy, before September ... the functional outcome of knees with a surviving FOCA, as assessed using the modified Hospital for Special ... years). Forty-eight conversions to arthroplasty or another FOCA procedure had been performed at a mean of ...
Tópico(s): Osteoarthritis Treatment and Mechanisms
2019 - Wolters Kluwer | Journal of Bone and Joint Surgery
Michelle Kammel, Doreen Hunger, R. Gary Sawers,
FocA belongs to the pentameric FNT (formate-nitrite transporter) superfamily of anion channels, translocating formate bidirectionally across ... other microorganisms. While the membrane-integral core of FocA shares considerable amino acid sequence conservation with other ... not. To analyze the potential biochemical function of FocA's N-terminal domain in vivo, we constructed ... sensitive reporter system. Analysis of strains synthesizing these FocA variants provided insights into formate efflux. Strains lacking ...
Tópico(s): Amino Acid Enzymes and Metabolism
2020 - Wiley | Molecular Microbiology
Michelle Kammel, R. Gary Sawers,
FocA translocates formate/formic acid bi-directionally across the cytoplasmic membrane when Escherichia coli grows by fermentation. ... unclear, however, what physiological benefit is imparted by FocA, because formic acid (p K a =3.75) ... E. coli K-12 strain with its isogenic focA mutant. Our results show that, regardless of the initial pH in the culture, FocA functions to maintain relatively constant intracellular formate levels during growth. Analysis of a strain synthesizing a FocA T91A variant with an exchange in a conserved ...
Tópico(s): Protein Structure and Dynamics
2022 - Microbiology Society | Microbiology
Dörte Falke, Kristin Schulz, Claudia Doberenz, Lydia Beyer, Hauke Lilie, Barbara Thiemer, R. Gary Sawers,
FocA is a predicted formate channel with a deduced mass of 31 kDa that catalyzes the bidirectional ... of the formate-nitrite transporter (FNT) family. Overproduced FocA variants with either an N- or a C- ... copy formate-dependent fdhF::lacZ fusion. Using anti-FocA antibodies, we could show that both FocA variants were integrated into the cytoplasmic membrane. Circular dichroism spectroscopy of purified FocA(Strep-N) revealed a high alpha-helical content ... state by blue-native polyacrylamide gel electrophoresis revealed FocA to have an unexpected pentameric quaternary structure. This ...
Tópico(s): RNA and protein synthesis mechanisms
2009 - Oxford University Press | FEMS Microbiology Letters
Summary The anaerobically inducible dicistronic focA‐pfl operon is transcribed from three co‐ordinately regulated promoters that are located 5′ of the operon. Remarkably, the 5′ ends ... abundant operon‐internal transcripts are located within the focA gene, with a fifth transcript mapping in the intergenic region between focA and pfl . The findings of this study demonstrate ... T7Φ 10 promoter was introduced upstream of the focA‐pfl operon, mainly full‐length transcript and a ... transcript‐processing pattern. Moreover, processing was independent of focA translation. Taken together, these data suggest that processing ...
Tópico(s): RNA Research and Splicing
2005 - Wiley | Molecular Microbiology
Li Dong, Hechun Li, Zhongqiong He, Sisi Jiang, Benjamin Klugah‐Brown, Lin Chen, Pu Wang, Song Tan, Cheng Luo, Dezhong Yao,
... ur‐dimensional (spatiotemporal) Consistency of local neural Activities ( FOCA ) was used to assess the spatiotemporal consistency of ... sample t test was performed to detect the FOCA differences between two groups. Partial correlations between the FOCA values and durations of epilepsy were further analyzed. ... Findings Compared with controls, FLE patients demonstrated increased FOCA in distant brain regions including the frontal and ... as well as the basal ganglia. The decreased FOCA was located in the temporal cortex, posterior default ...
Tópico(s): Advanced MRI Techniques and Applications
2016 - Wiley | Brain and Behavior
B Hakobyan, Constanze Pinske, R. Gary Sawers, Armen Trchоunian, Karen Trchounian,
Escherichia coli encodes two formate channels, FocA and FocB, that either export formate or import it for further disproportionation by the formate hydrogenlyase (FHL) complex to H2 and CO2. We show that FocA/B appear to change their substrate-translocation direction ... pH 7.5, formate accumulated in focB or focA-focB mutants when glucose or formate was used ... the growth medium increased H2 production in a focA-focB mutant. This indicates that in the wild ... exported at pH 7.5 and that another FocA/B-independent uptake system exists. At pH 6. ...
Tópico(s): Bacterial Genetics and Biotechnology
2018 - Oxford University Press | FEMS Microbiology Letters
Weijia Gao, Dong Cui, Qing Jiao, Linyan Su, Guangming Lu, Rongwang Yang,
... Four-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) was employed to detect the local brain activity ... tests. Results The ANOVA obtained significant among-group FOCA differences in the left triangular inferior frontal gyrus, ... control group, the P-PBD group showed decreased FOCA in the left supplementary motor area and bilateral superior frontal gyrus and showed increased FOCA in the left triangular inferior frontal gyrus. In contrast, the NP-PBD group exhibited decreased FOCA in the right superior occipital gyrus and right ...
Tópico(s): Schizophrenia research and treatment
2021 - BioMed Central | BMC Psychiatry
Michelle Kammel, Oliver Trebbin, Constanze Pinske, R. Gary Sawers,
... it at lower pH. This is performed by FocA, the archetype of the formate-nitrite transporter (FNT) family of pentameric anion channels. Each protomer of FocA has a hydrophobic pore through which formate/formic ... the direction of formate/formic acid passage through FocA is controlled by pH. A conserved histidine residue ( ... in formate levels in vivo when H209 in FocA was exchanged for either of the non-protonatable ... glutamine, which occur naturally in some FNTs. These FocA variants (with N or Q) functioned as highly ...
Tópico(s): Metabolism and Genetic Disorders
2022 - Microbiology Society | Microbiology
Elaine F. Reed, Denise Thompson, Richard Mayeaux, Nicole Suciu‐Foca,
... Search for more papers by this authorNicole Suciu-Foca, Corresponding Author Nicole Suciu-Foca Columbia University College of Physicians and Surgeons, Department ... Y., U.S.A.Address: Dr. Nicole Suciu-Foca Columbia University College of Physicians and Surgeons Department ... Search for more papers by this authorNicole Suciu-Foca, Corresponding Author Nicole Suciu-Foca Columbia University College of Physicians and Surgeons, Department ... Y., U.S.A.Address: Dr. Nicole Suciu-Foca Columbia University College of Physicians and Surgeons Department ...
Tópico(s): Tryptophan and brain disorders
1983 - Wiley | Tissue Antigens
Elaine F. Reed, Amy Lewison, Richard Mayeaux, Nicole Suciu‐Foca,
... Search for more papers by this authorNicole Suciu-Foca, Corresponding Author Nicole Suciu-Foca Columbia University College of Physicians and Surgeons, Department ... Y., U.S.A.Address: Dr. Nicole Suciu-Foca Columbia University College of Physicians and Surgeons 630 ... Search for more papers by this authorNicole Suciu-Foca, Corresponding Author Nicole Suciu-Foca Columbia University College of Physicians and Surgeons, Department ... Y., U.S.A.Address: Dr. Nicole Suciu-Foca Columbia University College of Physicians and Surgeons 630 ...
Tópico(s): Immunotherapy and Immune Responses
1983 - Wiley | Tissue Antigens
Wei Lü, Juan Du, Nikola J. Schwarzer, Elke Gerbig-Smentek, Oliver Einsle, Susana L. A. Andrade,
... cellular membranes by the pentameric ion channel/transporter FocA that, together with the nitrite channel NirC, forms ... we have carried out an electrophysiological analysis of FocA from Salmonella typhimurium to characterize the channel properties ... structural rearrangements in the transport channel of each FocA protomer. Moreover, FocA did not conduct cations or divalent anions, but ... of anaerobic mixed-acid fermentation, the pathway where FocA is predominantly required, so that this channel is ...
Tópico(s): Metabolism and Genetic Disorders
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
In the Foça Region, a complete Miocene volcano-sedimentary succession outcrops. This succession includes a well-developed central volcano gradually interdigitating ... vertically interdigitating rock associations; the Yuntdağ volcanics, the Foça volcanics and the Aliağa limestones. The lowermost unit ... laterally into and is overlain by the rhyolitic Foça volcanics that erupted along the flank of the ... domes and dykes. In the uppermost parts, the Foça volcanics include sporadic occurrences of alkaline dykes and ...
Tópico(s): Geology and Paleoclimatology Research
2004 - Elsevier BV | Journal of Asian Earth Sciences
Li Dong, Cheng Luo, Weifang Cao, Rui Zhang, Jinnan Gong, Diankun Gong, Dezhong Yao,
... FOur‐dimensional (spatiotemporal) Consistency of local neural Activities (FOCA). Then three experiments included resting state data (33 ... motor execution task, 26 subjects) were designed. Finally, FOCA were respectively analyzed using statistical analysis methods, such ... etc. Results During resting state (Experiment 1), the FOCA values ( P < 0.05, family‐wise error [FWE] ... 8) and between subjects (correlation ≈0.6) of FOCA were obtained. Comparing event with resting state in Experiment 3, enhanced FOCA ( P < 0.05, FWE‐corrected, voxel size >621 ...
Tópico(s): Neural dynamics and brain function
2014 - Wiley | Journal of Magnetic Resonance Imaging
Dörte Falke, Claudia Doberenz, Doreen Hunger, R. Gary Sawers,
... cell. The FNT (formate-nitrite transporter) membrane channel FocA ensures formate is translocated across the cytoplasmic membrane. ... study that TdcE, like PflB, interacts specifically with FocA. His-tagged variants of two other predicted GREs ... purified and were shown not to interact with FocA, indicating that interaction with FocA is not a general property of GREs per ... like PflB, TdcE can control formate translocation by FocA.
Tópico(s): Enzyme Structure and Function
2016 - Elsevier BV | Biochemistry and Biophysics Reports
Attila Aydemir, Funda Bilim, Günay Çifçi, Seda Okay,
... anomaly extending in the NE-SW direction between Foca and Uzunada (Uzun Island) in the gulf. Previously, ... found from 7 km in the NE of Foca to 10 km through the south of the ... flow anomalies are shifted through the north of Foca and Aliaga towns in the Candarli Bay. This ... that were encountered at 969 m in the Foca-1 well although it was drilled about 2 ... that the causative body is inclined through the Foca Peninsula. However, its closed contours are in the ...
Tópico(s): Geology and Paleoclimatology Research
2018 - Elsevier BV | Journal of Asian Earth Sciences
Naman R. Rao, Nathaniel S. Treister, Andrea L. Axtell, Jillian Muhlbauer, Puhan He, Agnes Lau, Ross Icyda, Elbert Heng, Daniel Rinewalt, Siobhan McGurk, Kevin F. Kennedy, Tsuyoshi Kaneko, Duke E. Cameron, Hervé Sroussi,
... preoperative dental screening (PDS) approaches, a focused approach (FocA) and a comprehensive approach (CompA), to compare postsurgical ... surgery at Brigham and Women's Hospital with FocA and Massachusetts General Hospital with CompA of PDS ... 1835 patients were included in the study. With FocA 96% of patients (1097/1143) received dental clearance ... 14]). Reoperation due to infection was less in FocA (0.5%) vs CompA (2.6) (P < .001) and postoperative septicemia was increased in the FocA (1.7%) cohort when compared to the CompA ( ...
Tópico(s): Cardiac Valve Diseases and Treatments
2020 - Wiley | Journal of Cardiac Surgery
R. W. Darrell, Nicole Suciu‐Foca,
... Search for more papers by this authorNicole Suciu-Foca, Nicole Suciu-Foca Departments of Ophthalmology and Pathology Columbia University, New ... Search for more papers by this authorNicole Suciu-Foca, Nicole Suciu-Foca Departments of Ophthalmology and Pathology Columbia University, New ...
Tópico(s): T-cell and B-cell Immunology
1981 - Wiley | Tissue Antigens
... year period between 1994 and 1998 in the Foça Pilot Monk Seal Conservation Area. The identification of ... male and one of unknown sex.). Islands off Foça town provide suitable habitats and promote the survival ... 1998 in einer fünfjährigen Untersuchungsperiode im Mönchsrobbenschutzgebiet von Foça untersucht. Für die individuelle Erkennung von Robben im ... mit unbekanntem Geschlecht). Auf den vor der Stadt Foça gelegenen Inselchen gibt es passende Habitate, die das ...
Tópico(s): Marine animal studies overview
2003 - Taylor & Francis | Zoology in the Middle East
Karen Trchounian, Armen Trchоunian,
... dependence of H2 production on the formate channels, FocA and FocB, by Escherichia coli at pH 5. ... 6.5 and 7.5 was shown using focA and focB mutants and comparing with the wild ... through FocB at different pHs; external formate drives FocA to import direction. However, during glycerol fermentation formate ... through FocB, whereas formate is exported preferentially through FocA at pH 7.5.
Tópico(s): Microbial Fuel Cells and Bioremediation
2014 - Elsevier BV | International Journal of Hydrogen Energy
Pu Wang, Xiangdong Luo, Chengqing Zhong, Lili Yang, Fuqiang Guo, Nengwei Yu,
... FOur-dimensional (spatiotemporal) Consistency of local neural Activities (FOCA) the abnormal synchronization of fMRI signals in ET ... gFCD) were analyzed in the regions exhibiting significant FOCA differences. Compared with healthy controls, patients with ET showed the increased FOCA values found in the bilateral cuneus, the left ... right postcentral gyrus, the pallidum and putamen. Decreased FOCA values in ET patients were located in the ... non-motor areas. This work also demonstrated that FOCA and functional connectivity have the potential to provide ...
Tópico(s): Advanced MRI Techniques and Applications
2018 - Elsevier BV | Journal of the Neurological Sciences