Vincent A. Voelz, Vijay S. Pande, Gregory R. Bowman,
... extremely demanding calculations. For over twenty years, the Folding@home distributed computing project has pioneered a massively parallel ... project's name implies, the early years of Folding@home focused on driving advances in our understanding of ... laid a foundation for broadening the scope of Folding@home to address other functionally relevant conformational changes, such ... GPU-based computing, and the growing scale of Folding@home have enabled the project to focus on new ... to come as exascale supercomputers come online, and Folding@home continues its work.
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2023 - Elsevier BV | Biophysical Journal
Folding@home is a distributed computing project in which participants run protein folding simulations on their computers. Participants ... hardware enthusiasts," use distributed computing projects such as Folding@home to benchmark their modified computers and to compete ... they learn more about the scientific outputs of Folding@home, some participants become more motivated by the desire ... in their computers and process the majority of Folding@home's simulations, thus providing an invaluable (and free) ...
Tópico(s): Mobile Crowdsensing and Crowdsourcing
2018 - Ubiquity Press | Citizen Science Theory and Practice
Daniel L. Ensign, Vijay S. Pande,
... magnitude faster computation than conventional processors. Using the Folding@home distributed computing system, we generated thousands of independent ...
Tópico(s): Enzyme Structure and Function
2009 - Elsevier BV | Biophysical Journal
Vincenzo D. Cunsolo, Salvatore Distefano, Antonio Puliafito, Marco Scarpa,
... Volunteer computing projects such as SETI@home and FOLDING@home and the great flexibility and power of the ...
Tópico(s): Peer-to-Peer Network Technologies
2009 - Springer Science+Business Media | Lecture notes in computer science
Olivier Beaumont, Nicolas Bonichon, Philippe Duchon, Lionel Eyraud‐Dubois, Hubert Larchevêque,
... scale distributed platforms, such as BOINC, WCG or Folding@home. In this context, applications mostly consist in a ...
Tópico(s): Distributed systems and fault tolerance
2008 - Springer Science+Business Media | Lecture notes in computer science
Antonija Kuzmanic, Bojan Žagrović,
... headpiece generated using distributed-computing techniques and the Folding@Home cluster. Our results provide a basis for quantifying ...
Tópico(s): Probabilistic and Robust Engineering Design
2010 - Elsevier BV | Biophysical Journal
Morten Hagen, Byungchan Kim, Pu Liu, Richard A. Friesner, B. J. Berne,
... systems on worldwide distributed computing environments, such as Folding@Home. For proof of concept, we apply the SREM ...
Tópico(s): Origins and Evolution of Life
2007 - American Chemical Society | The Journal of Physical Chemistry B
Kyle A. Beauchamp, Robert T. McGibbon, Yu‐Shan Lin, Vijay S. Pande,
... fourteen massive simulation datasets generated by Anton and Folding@home. Our protocol quantitatively identifies the suitability of describing ...
Tópico(s): RNA and protein synthesis mechanisms
2012 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Neelan J. Marianayagam, Nicolas L. Fawzi, Teresa Head‐Gordon,
... distributed computing (DC) paradigm in conjunction with the folding@home (FH) client server has been used to study ...
Tópico(s): Nanopore and Nanochannel Transport Studies
2005 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Asghar M. Razavi, William M. Wuest, Vincent A. Voelz,
... favorable of these for massively parallel simulation on Folding@home in explicit solvent. Markov state models (MSMs) built ...
Tópico(s): Protein Structure and Dynamics
2014 - American Chemical Society | Journal of Chemical Information and Modeling
Alex Bateman, Janet Kelso, Daniel Mietchen, Geoff Macintyre, Tomás Di Domenico, Thomas Abeel, Darren W. Logan, Predrag Radivojac, Burkhard Rost,
... Multiple Sequence Alignment, Genome Wide Association Study, and Folding@home. Figure 1 The computational biology articles rated by ...
Tópico(s): Cancer Genomics and Diagnostics
2013 - Public Library of Science | PLoS Computational Biology
... how proteins fold. More specifically, the Folderol and Folding@home projects are attempting to shed light on the ...
Tópico(s): Computational Physics and Python Applications
2001 - AIP Publishing | Computing in Science & Engineering
Asghar M. Razavi, Vincent A. Voelz,
... GB1 hairpin, trpzip4, trpzip5, and trpzip6 performed on Folding@home, Markov State Models (MSMs) were constructed using a ...
Tópico(s): Fungal and yeast genetics research
2015 - American Chemical Society | Journal of Chemical Theory and Computation
Christian R. Schwantes, Diwakar Shukla, Vijay S. Pande,
... performing 1.5 ms of additional sampling on Folding@home, we found an intermediate with a register-shift ...
Tópico(s): Particle physics theoretical and experimental studies
2016 - Elsevier BV | Biophysical Journal
Daniel L. Parton, Patrick Grinaway, Sonya M. Hanson, Kyle A. Beauchamp, John D. Chodera,
... computer clusters, supercomputers, or distributed computing projects like Folding@home. Ensembler thus automates much of the time-consuming ...
Tópico(s): Enzyme Structure and Function
2016 - Public Library of Science | PLoS Computational Biology
Guangfeng Zhou, Vincent A. Voelz,
... all-atom molecular dynamics simulations performed on the Folding@home distributed computing platform. Using Markov State Models, we ...
Tópico(s): Chemical Synthesis and Analysis
2016 - American Chemical Society | The Journal of Physical Chemistry B
Ge Yunhui, Brandon L. Kier, Niels H. Andersen, Vincent A. Voelz,
... designs, we additionally performed parallel simulations on the Folding@home distributed computing platform using AMBER ff99sb-ildn-NMR ...
Tópico(s): Protein Structure and Dynamics
2017 - American Chemical Society | Journal of Chemical Information and Modeling
Ge Yunhui, Elias Borne, Shannon Stewart, Michael Riis Hansen, Emilia Arturo, Eileen K. Jaffe, Vincent A. Voelz,
... the GROMACS molecular dynamics simulation suite on the Folding@home computing platform to perform extensive molecular simulations and ...
Tópico(s): Protein Structure and Dynamics
2018 - Elsevier BV | Journal of Biological Chemistry
... earth. Sadly, processing resources assigned to the corresponding Folding@home project cannot be shared with other volunteer computing ...
Tópico(s): IoT and Edge/Fog Computing
2020 - Multidisciplinary Digital Publishing Institute | Future Internet
Maxwell I. Zimmerman, Justin R. Porter, Michael D. Ward, Sukrit Singh, Neha Vithani, Artur Meller, Upasana L. Mallimadugula, Catherine E. Kuhn, Jonathan Borowsky, Rafal Wiewiora, Matthew F. D. Hurley, Aoife M. Harbison, Carl A. Fogarty, Joseph E. Coffland, Elisa Fadda, Vincent A. Voelz, John D. Chodera, Gregory R. Bowman,
... a million citizen scientists banded together through the Folding@home distributed computing project to create the first exascale ...
Tópico(s): Bacteriophages and microbial interactions
2021 - Nature Portfolio | Nature Chemistry
James Cipar, Mark D. Corner, Emery D. Berger,
... a shared pool. Applications such as SETI@home, Folding@home, and Freenet are now in wide use and ...
Tópico(s): Peer-to-Peer Network Technologies
2007 - Association for Computing Machinery | ACM Transactions on Storage
A. C. Forti, Ivan Glushkov, L. Heinrich, M. Lassnig, D. South, R. Walker,
... Force, it was decided to engage in the Folding@Home initiative, which provides payloads that perform protein folding ...
Tópico(s): Advanced Data Storage Technologies
2021 - EDP Sciences | EPJ Web of Conferences
Henrique Antoun, André Custódio Pecini,
Tópico(s): Caching and Content Delivery
2006 - Universidad de Los Hemisferios | Razón y Palabra
... was becoming more powerful; distributed systems (e.g, Folding@home), special-purpose machines (e.g, ANTON), and GPU- ...
Tópico(s): Machine Learning in Bioinformatics
2016 - Science China Press | Chinese Science Bulletin (Chinese Version)
Rafal Wiewiora, Shi Chen, Kyle A. Beauchamp, Minkui Luo, John D. Chodera,
Epigenetic regulation is essential for eukaryotic organisms in processes spanning from embryo development to longevity. Histone lysine methyltransferases (HKMTs) are amongst the key players that control these processes. HKMT dysregulation via mutation or altered expression has been implicated in many cancers' initiation, maintenance, aggressiveness and metastasis. Furthermore, roles of HKMTs in aging and drug addition have been shown in animal models. Development of selective inhibitors for many ...
Tópico(s): Cancer-related gene regulation
2017 - Elsevier BV | Biophysical Journal
... over 1 million volunteer computing devices using the Folding@home platform. Grids and clouds both can also be ...
Tópico(s): Artificial Intelligence in Healthcare
2022 - Ediciones Universidad de Salamanca | ADCAIJ ADVANCES IN DISTRIBUTED COMPUTING AND ARTIFICIAL INTELLIGENCE JOURNAL
... One of the founders ofthe distributed computing project Folding@Home, Bojan Zagrovic aims to set up the second control center of the Folding@Home network (currently numbering more than 250,000 processors), ...
Tópico(s): Biotechnology and Related Fields
2008 - Wiley | IUBMB Life
Benjamin Pham, Carolyn C. Kusaba, Mona Bakhom, Richard Wang, Eric J. Sorin,
... but have only ~50% sequence similarity. Using the Folding@Home distributed computing network and our new Pathway Enumeration ... This work was made possible by the worldwide Folding@Home volunteers who contributed invaluable processor time, Women & Philanthropy, ...
Tópico(s): Bacteriophages and microbial interactions
2012 - Wiley | The FASEB Journal
Samantha Cao, Benjamin Pham, Amethyst Radcliffe, Phuc La, Richard Wang, Yi An, Eric J. Sorin,
... in the active site of BuChE. Using the Folding@Home Distributed Computing Network, 8,000 all‐atom molecular ... This work was made possible by the worldwide Folding@Home volunteers who contributed invaluable processor time; Women & Philanthropy, ...
Tópico(s): Enzyme Catalysis and Immobilization
2012 - Wiley | The FASEB Journal
Tylar Seiya Farmer, Patrick Bohse, Dianne Kerr,
... perform the manipulation of proteins. Two free programs, “Folding@home and “Foldit”, allow anyone with a computer and internet access to contribute to protein engineering. Folding@home relies on one’s computational power, while Foldit ...
Tópico(s): Genetically Modified Organisms Research
2018 - rScroll | Journal of Student Research