Patricia Ferreira-Lopes, Francisco Sebastián Pinto Puerto,
This article describes the development of a database management system (DBMS), to use as the basis for a dynamic spatial model or historical geographic information system (HGIS), and an abstract-relational model or dynamic graph model to allow historians and architects to visualise and analyse the complexity of built heritage on a territorial scale. Reutilisation, interoperability, standard terminology and usability were all taken into account in the development of the models. The database was developed ...
Tópico(s): Urban Planning and Valuation
2018 - Elsevier BV | Digital Applications in Archaeology and Cultural Heritage
Produção Nacional
Revisado por pares
Sarah Santiloni Cury, Rainer Marco López Lapa, Julia Bette Homem de Mello, Fábio Albuquerque Marchi, Maria Aparecida Custódio Domingues, Clóvis Antônio Lopes Pinto, Robson Francisco Carvalho, Genival Barbosa de Carvalho, Luiz Paulo Kowalski, Sílvia Regina Rogatto,
The tumor secretome deconvolution is a promising strategy to identify diagnostic and prognostic biomarkers. Here, transcriptomic-based secretome analysis was performed aiming to discover laryngeal squamous cell carcinomas (LSCC) biomarkers from potentially secreted proteins (PSPs). The tumor expression profile (35 LSCC biopsies compared with surrounding normal tissues - SN) revealed 589 overexpressed genes. This gene list was used for secretome analysis based on laryngeal tumors and related secretome ...
Tópico(s): Machine Learning in Bioinformatics
2020 - Elsevier BV | Oral Oncology
Produção Nacional
Revisado por pares
Eufrânio N. da Silva Júnior, Maria Cecília B. V. de Souza, Michelle C. Fernandes, Rubem F. S. Menna‐Barreto, Maria do Carmo F. R. Pinto, Francisco de Assis da Silva Lopes, Carlos A. de Simone, Carlos Kleber Z. Andrade, António Pinto, Vı́tor F. Ferreira, Solange L. de Castro,
New naphthoquinone derivatives were synthesized and assayed against bloodstream trypomastigote forms of Trypanosoma cruzi, the etiological agent of Chagas' disease. The compounds were rationalized based on hybrid drugs and appear as important compounds against this parasite. From nor-lapachol were prepared five substituted ortho-naphthofuranquinones, a non-substituted para-naphthofuranquinone, a new oxyrane and an azide and from α-lapachone a new non-substituted para-naphthofuranquinone. Other five ...
Tópico(s): Synthesis and Reactions of Organic Compounds
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry
B. Frias, Tiago Lopes, Rui Pinto, Francisco Cruz, Célia Duarte Cruz,
The lower urinary tract (LUT) comprises a storage unit, the urinary bladder, and an outlet, the urethra. The coordination between the two structures is tightly controlled by the nervous system and, therefore, LUT function is highly susceptible to injuries to the neuronal pathways involved in micturition control. These injuries may include lesions to the spinal cord or to nerve fibres and result in micturition dysfunction. A common trait of micturition pathologies, irrespective of its origin, is an ...
Tópico(s): Neuropeptides and Animal Physiology
2011 - Bentham Science Publishers | Current Neuropharmacology
Rui Pinto, André Silva, Tiago Lopes, João Silva, Carlos Silva, Francisco Cruz, P. Dinis,
... RESULTS AT 9-MONTHS FOLLOW-UP Rui A Pinto, André Silva, Tiago Lopes, João F Silva, Carlos M Silva, Francisco R Cruz, and Paulo O Dinis Rui A PintoRui A Pinto , André SilvaAndré Silva , Tiago LopesTiago Lopes , João F SilvaJoão F Silva , Carlos M SilvaCarlos M Silva , Francisco R CruzFrancisco R Cruz , and Paulo O DinisPaulo ... 2009 by American Urological AssociationMetricsAuthor Information Rui A Pinto More articles by this author André Silva More articles by this author Tiago Lopes More articles by this author João F Silva More articles by this author Carlos M Silva More articles by this author Francisco R Cruz More articles by this author Paulo ...
Tópico(s): Vascular anomalies and interventions
2009 - Lippincott Williams & Wilkins | The Journal of Urology
António E. Pinto, Saudade André, Myrcia Ferreira Lopes Nogueira, Elismauro Francisco Mendonça, Janine Soares,
Breast tumours with a DNA content higher than 4N (hypertetraploidy) are not well characterised. The aim of this study was to evaluate the clinical and biological characteristics of 51 hypertetraploid breast carcinomas selected from a series of 860 consecutive cases analysed by flow cytometry.The clinicopathological characteristics of the hypertetraploid group were compared with those of a control group of 138 non-hypertetraploid breast carcinomas. Breast tumours from patients submitted to surgery ...
Tópico(s): Cancer Cells and Metastasis
1997 - BMJ | Journal of Clinical Pathology
Patrícia Vieira, Carlos A. Pinto, José A. Lopes‐da‐Silva, Fabienne Remize, Francisco J. Barba, Krystian Marszałek, Ivonne Delgadillo, Jorge A. Saraiva,
This work aimed to study refrigeration storage (4 °C for 23 days) of yoghurt produced at 43 °C under sub-lethal high pressure, at 10, 20, 30 and 40 MPa, in comparison with the fermentation process at atmospheric pressure (0.1 MPa). Lactic acid bacteria (S. thermophilus and L. bulgaricus, LAB) and quality parameters like pH, titratable acidity, syneresis and colour were evaluated, along with textural analyses to infer how pressure would impact the obtained yoghurt along storage. Higher fermentation pressures ...
Tópico(s): Probiotics and Fermented Foods
2019 - Elsevier BV | LWT
Produção Nacional
Revisado por pares
Graziele C. Zanata, Larissa G. Pinto, Nicole Rodrigues da Silva, Alexandre H. Lopes, Francisco Fábio Bezerra de Oliveira, Ieda R. S. Schivo, Fernando Q. Cunha, Peter A. McNaughton, Thiago M. Cunha, Rangel L. Silva,
Paclitaxel (PCX) is the first-line choice for the treatment of several types of cancer, including breast, ovarian, and lung cancers. However, patients who receive even a single dose with PCX commonly develop mechanical and cold allodynia, a symptom known as PCX-associated acute pain syndrome (P-APS). Here, we assessed possible involvement of kinin-kallikrein and renin-angiotensin systems in P-APS in mice.Male mice C57Bl/6 wild type (WT) and knockouts for bradykinin receptors, B1 (B1-/- ) and B2 (B2-/- ), ...
Tópico(s): Ion channel regulation and function
2020 - Wiley | European Journal of Pain
Produção Nacional
Artur Soares Pinto, Vandeir Francisco Guimarães, João Alexandre Lopes Dranski, Fábio Steiner, Marlene de Matos Malavasì, Ubirajara Contro Malavasi,
Sementes de pinhão manso (Jatropha curcas L.) possuem características ortodoxas e requerem conhecimento sobre os fatores que afetam a manutenção de sua qualidade fisiológica. Assim, objetivou-se neste estudo identificar as condições adequadas de armazenamento para a manutenção da qualidade fisiológica de sementes de pinhão manso. Na avaliação dos métodos de armazenamento, utilizou-se delineamento inteiramente casualizado, em esquema fatorial 3x3+1, sendo os fatores constituídos por três embalagens ( ...
Tópico(s): Growth and nutrition in plants
2012 - SciELO | Revista Brasileira de Sementes
Produção Nacional
Revisado por pares
Leila Cristina Meneghetti, Mônica Regina Garcez, Luiz Carlos Pinto da Silva Filho, Francisco de Paula Simões Lopes Gastal,
Several studies have been conducted to characterise the static behaviour of structural elements strengthened with composites, but fewer data regarding the fatigue behaviour are available. The main purpose of this paper is to compare the fatigue strength of fibre-reinforced polymers strengthened and plain reinforced concrete beams and to develop an analytical model to predict the fatigue life using data from different experiments. The paper uses data from a larger study undertaken by the authors ...
Tópico(s): Structural Load-Bearing Analysis
2011 - ICE Publishing | Magazine of Concrete Research
Produção Nacional
Revisado por pares
Antônio José Steidle Neto, Daniela de Carvalho Lopes, Francisco de Assis de Carvalho Pinto, Sérgio Zolnier,
Vegetation biochemical and biophysical variables are important for many ecological, agronomic, and meteorological applications. Among the main variables, water and chlorophyll are essentials due to directly affect the plant photosynthetic capacity and crop productivity. The objective of this study was develop and validate models capable of estimating water and chlorophyll status in sunflower leaves under progressive water stress, based on the visible/near-infrared region (Vis/NIR) spectral reflectance ...
Tópico(s): Remote Sensing in Agriculture
2017 - Elsevier BV | Biosystems Engineering
Produção Nacional
Revisado por pares
Leila Cristina Meneghetti, Mônica Regina Garcez, Luiz Carlos Pinto da Silva Filho, Francisco de Paula Simões Lopes Gastal, Túlio Nogueira Bittencourt,
Abstract Fibre‐reinforced polymers (FRP) in the form of externally bonded reinforcement have been used successfully in the rehabilitation of concrete structures. Although considerable data has been produced on the performance of strengthened RC structures, the reliability of strengthened structures can be significantly reduced due to the variability in the FRP properties, especially when the wet layup technique is used. In addition to this, structural engineers are concerned about the durability ...
Tópico(s): Innovative concrete reinforcement materials
2013 - Wiley | Structural Concrete
Ricardo Ribeiro, Cátia Monteiro, Virgínia Cunha, Maria José Oliveira, Mariana Freitas, Avelino Fraga, Paulo Príncipe, Carlos Lobato, Francisco S. N. Lobo, António Morais, V. Silva, José Sanches-Magalhães, Jorge Oliveira, Francisco Pina, Anabela Mota‐Pinto, Carlos Lopes, Rui Medeiros,
Obesity is associated with prostate cancer aggressiveness and mortality. The contribution of periprostatic adipose tissue, which is often infiltrated by malignant cells, to cancer progression is largely unknown. Thus, this study aimed to determine if periprostatic adipose tissue is linked with aggressive tumor biology in prostate cancer.Supernatants of whole adipose tissue (explants) or stromal vascular fraction (SVF) from paired fat samples of periprostatic (PP) and pre-peritoneal visceral (VIS) anatomic ...
Tópico(s): Muscle Physiology and Disorders
2012 - BioMed Central | Journal of Experimental & Clinical Cancer Research
Tiago Antunes‐Lopes, Rui Pinto, Sérgio Barros, Francisco Botelho, Carlos Silva, Célia Duarte Cruz, Francisco Cruz,
We investigated urinary levels of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in healthy individuals and patients with overactive bladder.Urine from 40 healthy volunteers, half of them male and half female, was collected in the morning, afternoon and evening on 2 occasions 3 months apart. Morning urine samples were collected from 37 female naïve patients with overactive bladder. A total of 24 patients were followed. Urine was collected after ...
Tópico(s): Sexual function and dysfunction studies
2012 - Lippincott Williams & Wilkins | The Journal of Urology
Produção Nacional
Revisado por pares
Diego Ismael Rocha, Daniela Lopes Paim Pinto, Lorena Melo Vieira, Francisco André Ossamu Tanaka, Marcelo Carnier Dornelas, Wagner Campos Otoni,
The integration of cellular and molecular data is essential for understanding the mechanisms involved in the acquisition of competence by plant somatic cells and the cytological changes that underlie this process. In the present study, we investigated the dynamics and fate of Passiflora edulis Sims cotyledon explants that were committed to somatic embryogenesis by characterizing the associated ultrastructural events and analysing the expression of a putative P. edulis ortholog of the Somatic Embryogenesis ...
Tópico(s): Plant Parasitism and Resistance
2015 - Springer Science+Business Media | PROTOPLASMA
Luciana das Neves, Andreia Moreira, Francisco Taveira-Pinto, Maria de Lurdes Lopes, Fernando Veloso Gomes,
Nearshore submerged structures made of sand-filled geosystems are an interesting use for this type of coastal protection technology. These systems have an advantage over more traditional materials such as concrete units or rock, which is the limited and non-permanent impact on natural coastal processes. On top of that are also some important research achievements and improvements at the level of the materials. However, at more exposed hydraulic conditions under high wave energy its application is ...
Tópico(s): Fluid Dynamics Simulations and Interactions
2014 - Elsevier BV | Coastal Engineering
Produção Nacional
Revisado por pares
Aline de Oliveira Ribeiro Viana, João Gonçalves Filho, Ana Lúcia Noronha Francisco, Clóvis Antônio Lopes Pinto, Luiz Paulo Kowalski,
Most patients with papillary thyroid carcinoma have good prognosis; however, recurrence rates and the need of salvage treatment remain a significant problem for 5-40% of patients. Although several risk classifications based on clinicopathological prognostic factors are used, it is not possible to predict which patients will have a higher risk of recurrence. The objective of the study is to analyse the impact of cytokeratin-19 and Ki-67 immunoexpression as predictive markers of the risk of recurrence ...
Tópico(s): Head and Neck Anomalies
2020 - Pacini Editore Medicina | Acta Otorhinolaryngologica Italica
Rui Pinto, Tiago Lopes, João Silva, Carlos Silva, Paulo Dinis, Francisco Cruz,
We evaluate the efficacy and safety of repeated intratrigonal injections of onabotulinum toxin A in patients with bladder pain syndrome/interstitial cystitis.This is a single center, long-term, prospective study in which 16 women with bladder pain syndrome/interstitial cystitis refractory to standard treatment received 4 consecutive intratrigonal injections of onabotulinum toxin A. Onabotulinum toxin A (100 U) was injected under cystoscopic control in 10 trigonal sites, each receiving 10 U in 1 ml ...
Tópico(s): Urinary Tract Infections Management
2012 - Lippincott Williams & Wilkins | The Journal of Urology
Produção Nacional
Revisado por pares
Fernanda Rodas Pires Fernandes, Gina Jonasson Mousquer, Lisie Souza Castro, Marco Antonio Moreira Puga, Tayana Serpa Ortiz Tanaka, Grazielli Rocha de Rezende, Clarice Souza Pinto, Larissa Melo Bandeira, Regina Maria Bringel Martins, Roberta Barbosa Lopes Francisco, Sheila Araújo Teles, Ana Rita Coimbra Motta-Castro,
Female sex workers (FSWs) are considered a high-risk group for human immunodeficiency virus (HIV) infection due to their social vulnerability and factors associated with their work. We estimated the prevalence of HIV, and identified viral subtypes and risk factors among FSWs. A cross-sectional study using respondent-driven sampling (RDS) method was conducted among 402 FSWs in Campo Grande city, Brazil, from 2009 to 2011. Participants were interviewed using a standardized questionnaire about sociodemograpic ...
Tópico(s): Sexuality, Behavior, and Technology
2014 - Taylor & Francis | AIDS Care
Maria Adelaide Ferreira, Helena Calado, Carlos Pereira da Silva, António Domingos Abreu, Francisco Andrade, Catarina Fonseca, Emanuel J. Gonçalves, José Guerreiro, Francisco Noronha, Margarida Pereira, Carlos Pinto Lopes, Marta Chantal Ribeiro, Yorgos Stratoudakis, Lia Vasconcelos,
This contribution summarizes the main concerns presented by experts at a conference held in Lisbon in January 2015 to discuss the developing Portuguese legal framework for MSP and lists the suggestions that were correspondingly offered on how to improve the proposed framework.
Tópico(s): Maritime Ports and Logistics
2015 - Elsevier BV | Marine Policy
Produção Nacional
Revisado por pares
Clarisse Lopes de Castro Lobo, Jorge Francisco da Cunha Pinto, Emília Matos do Nascimento, Patrícia Moura, Gilberto Perez Cardoso, Jane S. Hankins,
Summary Although evidence is accumulating that hydroxycarbamide decreases mortality among adults with sickle cell disease ( SCD ), there are no published data regarding the effect of hydroxycarbamide on mortality among children. The Paediatric Hydroxycarbamide Program was established to treat children with SCD aged 3–18 years if they met disease severity criteria. Mortality data and clinical/laboratorial effects of hydroxycarbamide were retrospectively collected for the first 9 years of the Program. ...
Tópico(s): Blood groups and transfusion
2013 - Wiley | British Journal of Haematology
Produção Nacional
Revisado por pares
Stefanie Costa Pinto Lopes, Yara C. Blanco, Giselle Z. Justo, Paulo Afonso Nogueira, Francisco L. S. Rodrigues, Uta Goelnitz, Gerhard Wunderlich, Gustavo Facchini, Marcelo Brocchi, Nelsón Durán, Fábio Trindade Maranhão Costa,
ABSTRACT Violacein is a violet pigment extracted from the gram-negative bacterium Chromobacterium violaceum . It presents bactericidal, tumoricidal, trypanocidal, and antileishmanial activities. We show that micromolar concentrations efficiently killed chloroquine-sensitive and -resistant Plasmodium falciparum strains in vitro; inhibited parasitemia in vivo, even after parasite establishment; and protected Plasmodium chabaudi chabaudi -infected mice from a lethal challenge.
Tópico(s): Biochemical and Structural Characterization
2009 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Mauro F. Pinto, Adriana Leal, Fábio Lopes, José Pedro Pais, António Dourado, Francisco Sales, Pedro Martins, César Teixeira,
Seizure prediction may be the solution for epileptic patients whose drugs and surgery do not control seizures. Despite 46 years of research, few devices/systems underwent clinical trials and/or are commercialized, where the most recent state-of-the-art approaches, as neural networks models, are not used to their full potential. The latter demonstrates the existence of social barriers to new methodologies due to data bias, patient safety, and legislation compliance. In the form of literature review, ...
Tópico(s): Functional Brain Connectivity Studies
2022 - Wiley | Epilepsia Open
Lúcio Lara Santos, Céu Costa, Sofia Pereira, Maria Koch, Teresina Amaro, Fátima Cardoso, Talita Antunes Guimarães, María José Bento, Francisco S. N. Lobo, Sebastião Alves Pinto, Carlos Lopes,
Of patients with superficial bladder cancer, a group are still at risk of disease recurrence, progression and death from their cancer after curative treatment. Angiogenesis is a crucial pathogenic mechanism for this type of urothelial cell carcinoma (UCC), and is a potential therapeutic target. However, the selection of the appropriate patients remains a dilemma.Vascular endothelial growth factor (VEGF) expression and the presence of angiogenesis and occurrence of CD31, CD34, endoglin and factor VIII ...
Tópico(s): Urinary and Genital Oncology Studies
2003 - Elsevier BV | Annals of Oncology
Jaione Korro Bañuelos, Álvaro Rodríguez Miranda, José Manuel Valle Melón, Ainara Zornoza-Indart, Manuel Castellano Román, Roque Angulo Fornos, Francisco Sebastián Pinto Puerto, Pilar Ibáñez, Patricia Ferreira-Lopes,
Central to the entire discipline of heritage restoration and conservation is the concept of information management. Nevertheless, traditionally, conservation and restoration has been a poorly documented discipline, which has led not only to a lack of standardization and awareness about the processes carried out in the past, but also poses problems both when new restoration works are necessary and for the preventive conservation of the elements of heritage. This study sets out to propose a conceptual ...
Tópico(s): Cultural Heritage Management and Preservation
2021 - Multidisciplinary Digital Publishing Institute | Sustainability
Produção Nacional
Revisado por pares
Ana Lúcia Noronha Francisco, Wagner Correr, Clóvis Antônio Lopes Pinto, João Gonçalves Filho, Thiago Celestino Chulam, Cristina Kurachi, Luiz Paulo Kowalski,
Oral cancer is a public health problem with high prevalence in the population. Local tumor control is best achieved by complete surgical resection with adequate margins. A disease-free surgical margin correlates with a lower rate of local recurrence and a higher rate of disease-free survival. Fluorescence spectroscopy is a noninvasive diagnostic tool that can aid in real-time cancer detection. The technique, which evaluates the biochemical composition and structure of tissue fluorescence, is relatively ...
Tópico(s): Oral microbiology and periodontitis research
2014 - Elsevier BV | Oral Oncology
Rui Pinto, Tiago Lopes, João Silva, Carlos Silva, Paulo Dinis, Francisco Cruz,
... IN BLADDER PAIN SYNDROME/INTERSTITIAL CYSTITIS PATIENTS Rui Pinto, Tiago Lopes, João Silva, Carlos Silva, Paulo DInis, and Francisco Cruz Rui PintoRui Pinto Porto, Portugal , Tiago LopesTiago Lopes Porto, Portugal , João SilvaJoão Silva Porto, Portugal , Carlos SilvaCarlos Silva Porto, Portugal , Paulo DInisPaulo DInis Porto, Portugal , and Francisco CruzFrancisco Cruz Porto, Portugal View All Author Informationhttps:// ... Association Education and Research, Inc.MetricsAuthor Information Rui Pinto Porto, Portugal More articles by this author Tiago Lopes Porto, Portugal More articles by this author João Silva Porto, Portugal More articles by this author Carlos Silva Porto, Portugal More articles by this author Paulo DInis Porto, Portugal More articles by this author Francisco Cruz Porto, Portugal More articles by this author ...
Tópico(s): Sexual function and dysfunction studies
2013 - Lippincott Williams & Wilkins | The Journal of Urology
Filomena Pinto, Rui Neto André, Helena Lopes, Diogo Neves, Francisco Varela, João Santos, Miguel Miranda,
The world annual production of rice is higher than 700.7 million tons, which generates rice husk and straw wastes. Rice culture also produces big amounts of polyethylene (PE) bags used in rice packs and for seeds and fertilizer storage that usually end up in landfills, due to their degree of contamination. The energetic valorisation of these wastes may be accomplished by different processes, co-gasification is one of the most viable, as it leads to the production of a synthetic gaseous mixture (bio- ...
Tópico(s): Polymer crystallization and properties
2015 - AIDIC-Italian Association of Chemical Engineering | Chemical engineering transactions
Ricardo Ribeiro, André Vasconcelos, Sandra Costa, Daniela Pinto, António Morais, Jorge Oliveira, Francisco S. N. Lobo, Carlos Lopes, Rui Medeiros,
Abstract BACKGROUND Leptin has been consistently associated with angiogenesis and tumoral growth. A G/A single nucleotide polymorphism (SNP) at the −2548 site in leptin gene ( LEP ) is associated with overexpression of leptin (A‐allele). METHODS We evaluated DNA samples from 268 (536 alleles) unrelated individuals, 118 healthy controls (HCs) and 150 prostate cancer (PC) patients, for leptin gene ( LEP ) locus −2548 genotypes. RESULTS We found an overrepresentation of the A‐allele in PC patients and that there ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2003 - Wiley | The Prostate
Produção Nacional
Revisado por pares
Thisciane Ferreira Pinto, Pedro Felipe Carvalhedo de Bruin, Veralice Meireles Sales de Bruin, Paulo Marcos Lopes, Francisco Ney Lemos,
Obesity is commonly associated with poor sleep, excessive daytime sleepiness (EDS) and depressive mood but the impact of bariatric surgery on these conditions is incompletely understood. This study aimed to investigate the course of EDS and sleep quality in bariatric surgery patients in relation with changes in body weight and depressive symptoms. In patients consecutively submitted to bariatric surgery, baseline and postoperative sleep quality were evaluated by the Pittsburgh Sleep Quality Index ( ...
Tópico(s): Obesity, Physical Activity, Diet
2017 - Springer Science+Business Media | Obesity Surgery