Sina Brückner, Selidji Todagbé Agnandji, Johannes Elias, Stefan Berberich, Emmanuel B. Bache, José Francisco Fernandes, Marguerite Massinga Loembé, Johanna Haß, Bertrand Lell, Benjamin Mordmüller, Ayôla Akim Adégnika, Peter G. Kremsner, Meral Esen,
We recently described the effect of a single-dose antihelminthic treatment on vaccine immunogenicity to a seasonal influenza vaccine. Here we report the effect of antihelminthics on the immunogenicity of a meningococcal vaccine and a cholera vaccine in primary school children living in Lambaréné, Gabon. Since infection with helminths remains a major public health problem and the influence on cognitive and physical development as well as the immunomodulatory effects are well established, we investigated ...
Tópico(s): Parasite Biology and Host Interactions
2016 - Elsevier BV | Vaccine
Sina Brückner, Selidji Todagbé Agnandji, Stefan Berberich, Emmanuel B. Bache, José Francisco Fernandes, Brunhilde Schweiger, Marguerite Massinga Loembé, Thomas Engleitner, Bertrand Lell, Benjamin Mordmüller, Ayôla Akim Adégnika, Maria Yazdanbakhsh, Peter G. Kremsner, Meral Esen,
Background Helminth infections are a major public health problem, especially in the tropics. Infected individuals have an altered immune response with evidence that antibody response to vaccination is impaired. Hence, treatment of helminth infections before vaccination may be a simple intervention to improve vaccine immunogenicity. In the present study we investigated whether a single-dose antihelminthic treatment influences antibody responses to a seasonal influenza vaccine in primary school children ...
Tópico(s): Virology and Viral Diseases
2015 - Public Library of Science | PLoS neglected tropical diseases
Jean Claude Dejon‐Agobé, Ulysse Ateba-Ngoa, Albert Lalremruata, Andreas Homoet, Julie Engelhorn, Odilon Nouatin, Jean Ronald Edoa, José Francisco Fernandes, Meral Esen, Yoanne D. Mouwenda, Eunice M Betouke Ongwe, Marguerite Massinga Loembé, Stephen L. Hoffman, B. Kim Lee Sim, Michael Theisen, Peter G. Kremsner, Ayôla Akim Adégnika, Bertrand Lell, Benjamin Mordmüller,
Abstract Background GMZ2 is a recombinant malaria vaccine inducing immune responses against Plasmodium falciparum (Pf) merozoite surface protein-3 and glutamate-rich protein. We used standardized controlled human malaria infection (CHMI) to assess the efficacy of this asexual blood-stage vaccine. Methods We vaccinated 50 healthy, adult volunteers with lifelong exposure to Pf 3 times, at 4-week intervals, with 30 or 100 µg GMZ2 formulated in CAF01, a liposome-based adjuvant; 100 µg GMZ2, formulated ...
Tópico(s): Complement system in diseases
2018 - Oxford University Press | Clinical Infectious Diseases
Francisco José Martínez-Martínez, Arsénia J. Massinga, Áuria de Jesus, Rita Ernesto, Pablo Cano-Jiménez, Álvaro Chiner‐Oms, Inmaculada Gómez-Navarro, Marina Guillot-Fernández, Caterina Guinovart, António Sitoe, Delfino Vubil, Rubão Bila, Rufino Gujamo, Sónia Enosse, Santiago Jiménez, Manuela Torres‐Puente, Iñaki Comas, Inácio Mandomando, Mariana G. López, Alfredo Mayor,
BackgroundFrom the start of the SARS-CoV-2 outbreak, global sequencing efforts have generated an unprecedented amount of genomic data. Nonetheless, unequal sampling between high-income and low-income countries hinders the implementation of genomic surveillance systems at the global and local level. Filling the knowledge gaps of genomic information and understanding pandemic dynamics in low-income countries is essential for public health decision making and to prepare for future pandemics. In this ...
Tópico(s): Immune responses and vaccinations
2023 - Elsevier BV | The Lancet Global Health
... PubMed Google Scholar In the Lancet Global Health, Francisco José Martínez-Martínez and colleagues5Martínez-Martinez FJ Massinga AJ De Jesus Á et al.Tracking SARS- ...
Tópico(s): Viral gastroenteritis research and epidemiology
2023 - Elsevier BV | The Lancet Global Health
Emmanuel B. Bache, Selidji Todagbé Agnandji, Bertrand Lell, José Francisco Fernandes, Béatrice Peggy Abossolo, Anita L. Kabwende, Ayôla Akim Adégnika, Benjamin Gottlieb Mordmüller, Peter G. Kremsner, Marguerite Massinga Loembé, Abraham Alabi, Saadou Issifou,
Findings 8922 children and 6537 young infants were included in the modified intention-to-treat analyses. Children were followed up for a median of 48 months (IQR 39–50) and young infants for 38 months (34–41) after dose 1. From month 0 until study end, compared with 9585 episodes of clinical malaria that met the primary case definition in children in the C3C group, 6616 episodes occurred in the R3R group (VE 36·3%, 95% CI 31·8–40·5) and 7396 occurred in the R3C group (28·3%, 23·3–32·9); compared with ...
Tópico(s): Pharmaceutical Economics and Policy
2015 - Elsevier BV | The Lancet
Jacqueline Kyungah Lim, José Francisco Fernandes, In-Kyu Yoon, Jung-Seok Lee, Regis Maurin Obiang, Kang Sung Lee, Suk Namkung, Jae Seung Yang, So Hee Bae, Sl-Ki Lim, Bertrand Lell, Meral Esen, Marguerite Massinga Loembé, Peter G. Kremsner, Neâl Alexander, Selidji Todagbé Agnandji,
Background In Africa, information on dengue is limited to outbreak reports and focused on some countries with continuing transmission in West and East Africa. To estimate the proportion of dengue-positive cases among febrile patients and identify clinical indicators of dengue cases, we conducted passive facility-based fever surveillance in a catchment area population of 70,000 residents of Lambaréné and its surroundings in Gabon. Methods Non-malarial febrile patients with current fever or history ...
Tópico(s): Malaria Research and Control
2021 - Public Library of Science | PLoS neglected tropical diseases
Houriiyah Tegally, James Emmanuel San, Matthew Cotten, Monika Moir, Bryan Tegomoh, Gerald Mboowa, Darren P. Martin, Cheryl Baxter, Arnold W. Lambisia, Amadou Diallo, Daniel G. Amoako, Moussa Moïse Diagne, Abay Sisay, Abdel‐Rahman N. Zekri, Abdou Salam Guèye, Abdoul Karim Sangaré, Abdoul–Salam Ouédraogo, Abdourahmane Sow, Abdualmoniem O. Musa, Abdul Karim Sesay, Abe G. Abias, Adam Elzagheid, Adamou Lagaré, Adedotun-Sulaiman Kemi, Aden Elmi Abar, Adeniji A. Johnson, Adeola Fowotade, Oluwapelumi O. Adeyemi, Adrienne Amuri-Aziza, Agnes Juru, Ahmed Kandeil, Ahmed Mostafa, Ahmed Rebaï, Ahmed Sayed, Kazeem Akano, Aladje Baldé, Alan Christoffels, Alexander J. Trotter, Allan Campbell, Alpha Kabinet Keïta, A. Koné, Amal Bouzid, Amal Souissi, Ambrose Agweyu, Amel Naguib, Ana Victoria Gutiérrez, Anatole Nkeshimana, Andrew J. Page, Anges Yadouléton, Anika Vinzé, Anise N. Happi, Anissa Chouikha, Arash Iranzadeh, Arisha Maharaj, Armel L. Batchi‐Bouyou, Arshad Ismail, Augustina Angelina Sylverken, Augustine Goba, Femi Ayoade, Ayotunde E. Sijuwola, Baba M, Babatunde Lawal Salako, Bamidele Soji Oderinde, Bankole Bolajoko, Bassirou Diarra, Belinda L. Herring, Benjamin Tsofa, Bernard Lekana-Douki, Bernard Mvula, Berthe‐Marie Njanpop‐Lafourcade, Blessing T. Marondera, Bouh Abdi Khaireh, Bouréma Kouriba, Bright Adu, Brigitte Pool, Bronwyn McInnis, Cara E. Brook, Carolyn Williamson, Cassien Nduwimana, Catherine Anscombe, Catherine Pratt, Cathrine Scheepers, Chantal Akoua‐Koffi, Charles N. Agoti, Chastel M. Mapanguy, Cheikh Loucoubar, Chika Onwuamah, Chikwe Ihekweazu, Christian Malaka, Christophe N. Peyrefitte, Chukwa Grace, Chukwuma Ewean Omoruyi, Clotaire Donatien Rafaï, Collins M. Morang’a, Cyril Erameh, Daniel Lule Bugembe, Daniel J. Bridges, Daniel Mukadi‐Bamuleka, Daniel J. Park, David A. Rasmussen, David Baker, D. James Nokes, Deogratius Ssemwanga, Derek Tshiabuila, Dominic S. Y. Amuzu, Dominique Goedhals, Donald S. Grant, Donwilliams O. Omuoyo, Dorcas Maruapula, Dorcas Wanjohi, Ebenezer Foster-Nyarko, Eddy Kinganda-Lusamaki, Edgar Simulundu, Edidah M. Ong’era, Edith N. Ngabana, Edward Okoth Abworo, Edward Otieno, Edwin Shumba, Edwine Barasa, El Bara Ahmed, Elhadi Abdalla Ahmed, Emmanuel Lokilo, Enatha Mukantwari, Eromon Philomena, Essia Belarbi, Etienne Simon‐Lorière, Etilé A. Anoh, Eusébio Manuel, Fabian H. Leendertz, Fahn Taweh, Wasfi Farès, Fatma Abdelmoula, Faustinos Tatenda Takawira, Fawzi Derrar, Fehintola V. Ajogbasile, Florette K. Treurnicht, Onikepe Folarin, Francine Ntoumi, Francisca Muyembe, Frank Edgard Zongo Ragomzingba, Fred Athanasius Dratibi, Fred-Akintunwa Iyanu, Gabriel K. Mbunsu, Gaetän Thilliez, Gemma L. Kay, George O. Akpede, Gert U. van Zyl, Gordon A. Awandare, Grace Kpeli, Grit Schubert, Gugu Maphalala, Hafaliana C. Ranaivoson, Hannah E. Omunakwe, Harris Onywera, Haruka Abe, Héla Karray, Hellen Nansumba, Henda Triki, Herve Albéric Adje Kadjo, Hesham A. Elgahzaly, Hlanai Gumbo, Hota Mathieu, Hugo Kavunga‐Membo, Ibtihel Smeti, Idowu B. Olawoye, Ifedayo Adetifa, Ikponmwosa Odia, Ilhem Boutiba Ben Boubaker, Iluoreh Ahmed Muhammad, Isaac Ssewanyana, Isatta Wurie, Iyaloo Konstantinus, Jacqueline Wemboo Afiwa Halatoko, James Ayei, Janaki Sonoo, Jean-Claude Makangara-Cigolo, Jean‐Jacques Muyembe Tamfum, Jean‐Michel Héraud, Jeffrey G. Shaffer, Jennifer Giandhari, Jennifer Musyoki, Jerome Nkurunziza, Jessica N. Uwanibe, Jinal N. Bhiman, Jiro Yasuda, Joana Morais, Jocelyn Kiconco, John Demby Sandi, John Huddleston, John Kofi Odoom, John Mwita Morobe, John O. Gyapong, John Kayiwa, Johnson Okolie, Joicymara S. Xavier, Jones Gyamfi, Joseph Francis Wamala, Joseph Humphrey Kofi Bonney, Joseph Nyandwi, Josie Everatt, Joweria Nakaseegu, Joyce M. Ngoi, Joyce Namulondo, Judith U. Oguzie, Julia C. Andeko, Julius J. Lutwama, Juma J. H. Mogga, Justin O’Grady, Katherine J. Siddle, Kathleen Victoir, Kayode T. Adeyemi, Kefentse A. Tumedi, Kevin Sanders Da Rosa Carvalho, Khadija Said Mohammed, Koussay Dellagi, Kunda Musonda, Kwabena Obeng Duedu, Lamia Fki‐Berrajah, Lavanya Singh, Lenora Kepler, Leon Biscornet, Leonardo de Oliveira Martins, Lucious Chabuka, Luicer A. Ingasia, Lul Deng Ojok, Lul Lojok Deng, Lynette Isabella Ochola‐Oyier, Lynn Tyers, Madisa Mine, Magalutcheemee Ramuth, Maha Mastouri, Mahmoud ElHefnawi, Maïmouna Mbanne, M.I. Matsheka, Malebogo Kebabonye, Mamadou Diop, Mambu Momoh, Maria da Luz Lima Mendonça, Marietjie Venter, Mariétou F Paye, Martin Faye, Martin M. Nyaga, Mathabo Mareka, Damaris Matoke-Muhia, Maureen W. Mburu, Maxmillian Mpina, Michael Owusu, Michael R. Wiley, Mirabeau Youtchou Tatfeng, Mitoha Ondo’o Ayekaba, Mohamed Abouelhoda, Mohamed Amine Beloufa, Mohamed G. Seadawy, Mohamed K. Khalifa, Mooko Marethabile Matobo, Mouhamed Kane, Mounérou Salou, Mphaphi B. Mbulawa, Mulenga Mwenda, Mushal Allam, My V. T. Phan, Nabil Abid, Nadine Rujeni, Nadir Abuzaid, Nália Ismael, Nancy Elguindy, Ndeye Marième Top, Ndongo Dia, Nédio Mabunda, Marvin Hsiao, Nelson Boricó Silochi, Ngiambudulu M. Francisco, Ngonda Saasa, Nicholas Bbosa, Nickson Murunga, Nicksy Gumede, Nicole Wolter, Nikita Sitharam, Nnaemeka Ndodo, Nnennaya Anthony Ajayi, Noël Tordo, Nokuzola Mbhele, Norosoa Harline Razanajatovo, Nosamiefan Iguosadolo, Nwando Mba, Ojide C. Kingsley, Okogbenin Sylvanus, Femi Oladiji, Moses Olubusuyi Adewumi, Testimony Olumade, Olusola Ogunsanya, Oluwatosin Fakayode, Onwe Emeka Ogah, Ope-Ewe Oludayo, Ousmane Faye, Pamela Smith-Lawrence,
Investment in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequencing in Africa over the past year has led to a major increase in the number of sequences that have been generated and used to track the pandemic on the continent, a number that now exceeds 100,000 genomes. Our results show an increase in the number of African countries that are able to sequence domestically and highlight that local sequencing enables faster turnaround times and more-regular routine surveillance. Despite ...
American Association for the Advancement of Science
Francisco José Martínez-Martínez, Arsénia J. Massinga, Áuria de Jesus, Rita Ernesto, Pablo Cano-Jiménez, Álvaro Chiner‐Oms, Inmaculada Gómez-Navarro, Marina Guillot-Fernández, Caterina Guinovart, António Sitoe, Delfino Vubil, Rubão Bila, Rufino Gujamo, Sofía Viegas, Nália Ismael, Santiago Jiménez, Sónia Enosse, Manuela Torres‐Puente, Iñaki Comas, Inácio Mandomando, Mariana G. López, Alfredo Mayor,
Background: Since the SARS-CoV-2 outbreak, sequencing efforts from virtually all countries have led to an unprecedented amount of genome data from the virus. Even so, unequal sampling between Global North and South hinders the implementation of global genomic surveillance systems.Methods: UShER is able to reconstruct a phylogeny with millions of sequences by efficient sample placement in a tree. We used this tool to understand the dynamics of Beta and Delta waves in Mozambique, maximising the use ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2022 - RELX Group (Netherlands) | SSRN Electronic Journal
Conceição Pereira, José Rosado, Sofia G. Seabra, Francisco Pina‐Martins, Octávio S. Paulo, Paulo J. Fonseca,
... the individuals from the central/southern coast (Pomene/Massinga and Inhambane) and a third that assembled the ...
Tópico(s): Marine Sponges and Natural Products
2010 - Taylor & Francis | African Journal of Marine Science