José Molero, David Pérez Morales, Francisco José Brenes Bermúdez, Esperanza Pulido, A. Fernández-Pro, Juan Antonio Martín, Jesús Castiñeiras Fernández, José Manuel Cózar Olmo,
Benign prostatic hyperplasia (BPH) is a high prevalence condition in men over 50 years that requires continued assistance between primary care and urology. Therefore, consensus around common referral criteria was needed to guide and support both levels. Medical history, symptom assessment with International Prostate Symptom Score (IPSS) questionnaire, digital rectal examination and prostate-specific antigen (PSA) measurement are diagnostic tests available for general practitioners that allow setting ...
Tópico(s): Hormonal and reproductive studies
2009 - Elsevier BV | Atención Primaria
Sergio López, Sergio Montserrat‐de la Paz, Ricardo Lucas, Beatriz Bermúdez, Rocı́o Abia, Juan Carlos Morales, Francisco J.G. Muriana,
The effects of chemically synthesized metabolites (sulfate and glucuronate forms) from hydroxytyrosol (HTyr) on oxidative stress and inflammation were investigated in TNF-α-activated human endothelial cells. HTyr sulfate metabolites decreased reactive oxygen species and prevented the decrease in glutathione, glutathione peroxidase 1, and glutamate-cysteine ligase catalytic subunit and up-regulated heme oxygenase-1 levels. HTyr and all tested HTyr metabolites (HTyr sulfate > HTyr glucuronate > HTyr) suppressed ...
Tópico(s): Vanadium and Halogenation Chemistry
2017 - Elsevier BV | Journal of Functional Foods
Arturo Ávalos‐Fuentes, Santiago Loya‐López, Aleida Flores-Pérez, Sergio Recillas‐Morales, Hernán Cortés, Francisco Paz‐Bermúdez, Jorge Aceves, David Erlij, Benjamín Florán,
CaMKIIα is expressed at high density in the nucleus accumbens where it binds to postsynaptic D3 receptors inhibiting their effects. In striatonigral projections, activation of presynaptic D3 receptors potentiates D1 receptor-induced stimulation of cAMP production and GABA release. In this study we examined whether the presynaptic effects of D3 receptor stimulation in the substantia nigra reticulata (SNr) are modulated by Ca2+ activation of CaMKIIα. In SNr synaptosomes two procedures that increase ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2013 - Elsevier BV | Neuropharmacology
Arturo Ávalos‐Fuentes, Sacnité Albarrán‐Bravo, Santiago Loya‐López, Hernán Cortés, Sergio Recillas‐Morales, Jonathan J. Magaña, Francisco Paz‐Bermúdez, Claudia Rangel‐Barajas, Jorge Aceves, David Erlij, Benjamín Florán,
In striatonigral projections activation of dopamine D3 receptors (D3Rs) potentiates the stimulation of GABA release and cAMP production caused by activation of dopamine D1 receptors (D1Rs). Cytoplasmic [Ca2 +] in the terminals controls this response by modulating CaMKII, an enzyme that depresses D3R action. To examine the effects of dopamine deprivation on D3R signaling we investigated their function in striatonigral terminals of hemiparkinsonian rats. Denervation switched the signaling cascade initiated ...
Tópico(s): Neuroscience and Neuropharmacology Research
2014 - Elsevier BV | Neurobiology of Disease
Manuel Faundez‐Parraguez, Nicolas Farias-Rabelo, Juan Pablo González-Gutiérrez, Álvaro Etcheverry-Berríos, Jans Alzate‐Morales, Francisco Adasme‐Carreño, Rodrigo Varas, Isabel Bermúdez, Patricio Iturriaga‐Vásquez,
Nicotine is an agonist of nicotinic acetylcholine receptors (nAChRs) that has been extensively used as a template for the synthesis of α4β2-preferring nAChRs. Here, we used the N-methyl-pyrrolidine moiety of nicotine to design and synthesise novel α4β2-preferring neonicotinic ligands. We increased the distance between the basic nitrogen and aromatic group of nicotine by introducing an ester functionality that also mimics acetylcholine (Fig. 2). Additionally, we introduced a benzyloxy group linked ...
Tópico(s): Insect and Pesticide Research
2013 - Elsevier BV | Bioorganic & Medicinal Chemistry
Rodolfo Sánchez‐Zavaleta, José Arturo Ávalos‐Fuentes, Antonio Valentín González‐Hernández, Sergio Recillas‐Morales, Francisco Paz‐Bermúdez, Gerardo Leyva‐Gómez, Hernán Cortés, Benjamín Florán,
Striatal medium-sized spiny neurons express mRNA and protein of GPR55 receptors that stimulate neurotransmitter release; thus, GPR55 could be sent to nigral striatal projections, where it might modulate GABA release and motor behavior. Here, we study the presence of GPR55 receptors at striato-nigral terminals, their modulation of GABA release, their signaling pathway, and their effect on motor activity. By double immunohistochemistry, we found the colocation of GPR55 protein and substance P in the ...
Tópico(s): Cannabis and Cannabinoid Research
2022 - Wiley | Synapse
Maira Jiménez-Sánchez, Rebeca Pérez–Morales, Francisco M. Goycoolea, Monika Mueller, Werner Praznik, Renate Loeppert, Víctor H. Bermúdez-Morales, Guadalupe Zavala-Padilla, Marcela Ayala, Clarita Olvera,
Inulin has interesting physicochemical and functional properties, and therefore a wide range of applications in the food and medical industries. It has gained great traction due to its ability to form nanoparticles and its possible application as nanovehicle for drug delivery. In this work, we demonstrated that the enzymatically-synthesized high molecular weight (HMW) inulin forms stable spherical nanoparticles with an average diameter of 112 ± 5 nm. The self-assemblage of HMW inulin nanoparticles ...
Tópico(s): Enzyme Production and Characterization
2019 - Elsevier BV | Carbohydrate Polymers
Rafael Jijón‐Lorenzo, Isaac H. Caballero‐Florán, Sergio Recillas‐Morales, Hernán Cortés, José Arturo Ávalos‐Fuentes, Francisco Paz‐Bermúdez, David Erlij, Benjamín Florán,
Striatal dopamine D2 receptors activate the PLC → IP3 → Calcineurin-signaling pathway to modulate the neural excitability of En+ Medium-sized Spiny GABAergic neurons (MSN) through the regulation of L-type Ca2+ channels. Presynaptic dopaminergic D2 receptors modulate GABA release at striatopallidal terminals through L-type Ca2+ channels as well, but their signaling pathway is still undetermined. Since D2 receptors are Gi/o-coupled and negatively modulate adenylyl cyclase (AC), we investigated whether presynaptic ...
Tópico(s): Pain Mechanisms and Treatments
2017 - Elsevier BV | Neuroscience
Cristina Fernández‐Fernández, Juan Decara, Francisco J. Bermúdez‐Silva, Eva Sánchez, Paula Morales, María Gómez‐Cañas, María José Gómez, Luís F. Callado, Pilar Goya, Fernando Rodrı́guez de Fonseca, Marı́a Isabel Martı́n, Javier Fernández‐Ruíz, J. Javier Meana, Nadine Jagerovic,
Abstract A series of bivalent cannabinoid ligands is proposed. The synthesis of double amides based on the rimonabant structure separated by an alkyl chain and the evaluation of their affinities for cannabinoid receptors are reported. The data of 4d confirmed that a bivalent structure is a suitable scaffold for CB 1 cannabinoid receptor binding. The compound 4d was selected for in vitro and in vivo pharmacological evaluations. Moreover, intraperitoneal administration of 4d to food‐deprived rats ...
Tópico(s): Neurotransmitter Receptor Influence on Behavior
2013 - Wiley | Archiv der Pharmazie
Gabriel A. Morales, Lorenzo Márquez, M. Sáenz de Rodrigáñez, Laura Bermúdez, R. Robles, Francisco Javier Moyano,
To assess to what extent addition of phytase to a plant-based diet results in spatio-temporal changes of phytate, available P, soluble protein, total amino acids and the activity of the main digestive proteases in gilthead sea bream, fish were fed two plant-based diets with or without phytase. Stomach, proximal intestine and distal intestine contents were monitored for these parameters at 0, 1, 2, 4 and 6 h after feeding. A reduction (P < 0.0001) of the soluble P–IP6 in the stomach when phytase was ...
Tópico(s): Phytase and its Applications
2013 - Wiley | Aquaculture Nutrition
Concepción Morales-García, Teresa Rodrigo, Marta García‐Clemente, Ana Muñoz, Pilar García Bermudez, Francisco Casas Maldonado, María Salgado Somoza, Célia Milà, Antón Penas, Carmen Hidalgo, Martí Casals, Joan A. Caylà,
Under-reporting of tuberculosis (TB) cases complicates disease control, hinders contact tracing and alters the accuracy of epidemiological data, including disease burden. The objective of the present study is to evaluate the proportion of unreported TB cases in Spanish healthcare facilities and to identify the associated factors. A multi-center retrospective study design was employed. The study included TB cases diagnosed in 16 facilities during 2011–2012. These cases were compared to those reported ...
Tópico(s): Emergency and Acute Care Studies
2015 - BioMed Central | BMC Infectious Diseases
... AUC), 249, 252 Belgium, agenda-setting in, 108 Bermúdez, Francisco Morales, 22 Block Committee, 33n22 Blue Silicon Valley (lanseguigu), ...
2019 - Emerald Publishing Limited | Research in political sociology
María Luisa Quintero Soto, Javier Carreón Guillén, José Marcos Bustos Aguayo, Jorge Hernández Valdés, Gilberto Bermúdez Ruíz, Francisco Espinoza Morales, Arturo Sánchez Sánchez, Celia Yaneth Quiroz Campas, Rosa María Rincón Ornelas, María del Rosario Molina González, Cruz García Lirios,
Cervical Uterine Cancer is a disease that explains the vulnerability in which women are in terms of reproductive health with an impact on occupational health and public health, even when in Mexico the prevalence rate is lower than the other member countries of the OECD, its impact on Human Development and Local Development shows the importance that the disease have in communities more than in cities where prevention policies through check-ups and medical examinations seem to curb the trend, but ...
Tópico(s): Various Academic Research Studies
2023 - College of Science for Women, University of Baghdad | Baghdad Science Journal
O. Vigil‐Galán, E. Sánchez‐Meza, Carmen M. Ruiz, J. Sastré‐Hernández, Arturo Morales‐Acevedo, Francisco Cruz‐Gandarilla, J. Aguilar‐Hernández, Edgardo Saucedo, G. Contreras‐Puente, V. Bermúdez,
The physical properties of Bi doped CdTe films, grown on glass substrates by the Closed Space Transport Vapour (CSVT) method, from different Bi doped CdTe powders are presented. The CdTe:Bi films were characterized using Photoluminescence, Hall effect, X-Ray diffraction, SEM and Photoconductivity measurements. Moreover, CdS/CdTe:Bi solar cells were made and their characteristics like short circuit current density (Jsc), open circuit voltage (VOC), fill factor (FF) and efficiency (η) were determined. ...
Tópico(s): Silicon and Solar Cell Technologies
2007 - Elsevier BV | Thin Solid Films
M.C. Bermúdez Morales, Francisco González San Martín, B. Fernandez, D. Becerra García, Jaume Sampere, S. Carrasco Sánchez, S Serrano Ortega,
La biopsia selectiva del Ganglio Centinela (GC) se ofrece como una alternativa a la linfadenectomía regional convencional en el estadiaje de pacientes con melanoma cutáneo maligno. El objetivo de este trabajo es analizar nuestra experiencia en la localización del GC mediante linfogammagrafía y sonda detectora y su utilidad en el estadiaje del melanoma cutáneo maligno (MCM). Se estudiaron 100 pacientes, 56 mujeres y 44 hombres, con edad media de 51,5 ± 31,5 años, diagnosticados de MCM. En todos los casos ...
Tópico(s): Cell Image Analysis Techniques
2001 - Elsevier BV | Revista Española de Medicina Nuclear
Israel Conde Rojas, Jackeline Acosta‐García, René N. Caballero-Florán, Rafael Jijón‐Lorenzo, Sergio Recillas‐Morales, José Arturo Ávalos‐Fuentes, Francisco Paz‐Bermúdez, Gerardo Leyva‐Gómez, Hernán Cortés, Benjamín Florán,
Abstract Two major groups of terminals release GABA within the Globus pallidus; one group is constituted by projections from striatal neurons, while endings of the intranuclear collaterals form the other one. Each neurons' population expresses different subtypes of dopamine D2‐like receptors: D 2 R subtype is expressed by encephalin‐positive MSNs, while pallidal neurons express the D 4 R subtype. The D 2 R modulates the firing rate of striatal neurons and GABA release at their projection areas, ...
Tópico(s): Neuroscience and Neuropharmacology Research
2020 - Wiley | European Journal of Neuroscience
Francisco J.G. Muriana, Sergio Montserrat‐de la Paz, Ricardo Lucas, Beatriz Bermúdez, Sara Jaramillo, Juan Carlos Morales, Rocı́o Abia, Sergio López,
Novel biological activities for tyrosol metabolites on human endothelial cells.
Tópico(s): Traditional Chinese Medicine Analysis
2017 - Royal Society of Chemistry | Food & Function
S. Recillas-Morales, Lizzette Sanchez‐Vega, N. Ochoa-Sánchez, Isaac H. Caballero‐Florán, Francisco Paz‐Bermúdez, I. Silva, Jorge Aceves, David Erlij, Benjamín Florán,
Modulation of L-type Ca2+-channel function by dopamine is a major determinant of the rate of action potential firing by striatal medium spiny neurons. However, the role of these channels in modulating GABA release by nerve terminals in the basal ganglia is unknown. We found that depolarization-induced [3H]GABA release in both the substantia nigra reticulata and the external globus pallidus (GPe), was depressed by about 50% by either the selective L-channel dihydropyridine blocker nifedipine or the ...
Tópico(s): Neurological disorders and treatments
2013 - Elsevier BV | Neuroscience
... regime of General Juan Velazco Alvarado and General Francisco Morales Bermúdez—and during the 1980s—under presidents Fernando Belaunde ...
Tópico(s): Labor Movements and Unions
2002 - Cambridge University Press | International Labor and Working-Class History
... intellectual in the army by many, and General Francisco Morales Bermúdez, who along with Mercado Jarrín urged a more ...
Tópico(s): Politics and Society in Latin America
2005 - Duke University Press | Hispanic American Historical Review
... fue ministro del Interior bajo la dictadura de Francisco Morales Bermudez (1975 – 1980) y ministro de Guerra durante el ...
Tópico(s): Latin American Literature Analysis
2017 - Universidad Nacional de Cuyo | Cuadernos del CILHA
... second phase of the military rule by General Francisco Morales Bermudez in 1976 when the military had become unpopular ...
Tópico(s): Agriculture, Land Use, Rural Development
2022 - Duke University Press | Agricultural History
Claudia Cerda-Armijo, Mario Bermúdez de León, Irene Ruvalcaba-Ortega, Juan Chablé‐Santos, Ricardo Canales-del-Castillo, Katia Peñuelas-Urquides, Lydia Guadalupe Rivera-Morales, Griselda E Menchaca-Rodríguez, María Elena Camacho-Moll, Juan Francisco Contreras‐Cordero, Antonio Guzmán-Velasco, José I. González‐Rojas,
Aquatic wild birds, especially waterfowl, have been long considered the main reservoirs of the avian influenza A virus; however, recent surveys have found an important prevalence of these viruses among land birds as well. Migration has been suggested as an important factor in the avian influenza virus dissemination. We aimed to estimate the prevalence of influenza A viruses in wild birds (waterbirds and land birds; resident and migratory) in eastern Mexico, where the three main North American migration ...
Tópico(s): Animal Disease Management and Epidemiology
2020 - American Association of Avian Pathologists | Avian Diseases
Ïñigo Olalde, Swapan Mallick, Nick Patterson, Nadin Rohland, Vanessa Villalba‐Mouco, Marina Silva, Katharina Dulias, Ceiridwen J. Edwards, Francesca Gandini, Maria Pala, Pedro Soares, Manuel Ferrando-Bernal, Nicole Adamski, Nasreen Broomandkhoshbacht, Olivia Cheronet, Brendan J. Culleton, Daniel Fernandes, Ann Marie Lawson, Matthew Mah, Jonas Oppenheimer, Kristin Stewardson, Zhao Zhang, Juan Manuel Jimenéz Arenas, Isidro Jorge Toro Moyano, Domingo C. Salazar‐García, Pere Castanyer, Marta Santos, Joaquim Tremoleda i Trilla, Marina Lozano, Pablo García Borja, Javier Fernández Eraso, José Antonio Mujika Alustiza, Cecilio Barroso Ruíz, Francisco Javier Parra Bermúdez, Enrique Viguera, Josep Burch, Neus Coromina, David Vivó i Codina, Artur Cebrià, Josep María Fullola i Pericot, Oreto García Puchol, Juan Ignacio Morales, F. Xavier Oms, Tona Majó, Josep María Vergès, Antònia Díaz-Carvajal, Imma Ollich-Castanyer, F. Javier López-Cachero, Ana María Silva, Carmen Alonso Fernández, Germán Delibes de Castro, Javier Jiménez Echevarría, Adolfo Moreno Márquez, Guillermo Pascual Berlanga, Pablo Ramos‐García, José Ramos Muñoz, Eduardo Vijande Vila, Gustau Aguilella, Ángel Esparza Arroyo, Katina T. Lillios, Jennifer Mack, Javier Velasco Vázquez, A.J. Waterman, Luis Benítez de Lugo Enrich, María Benito Sánchez, Bibiana Agustí, Ferran Grau i Codina, Gabriel de Prado, Almudena Estalrrich, Álvaro Fernández Flores, Clive Finlayson, Geraldine Finlayson, Stewart Finlayson, Francisco Giles Guzmán, Antonio Rosas, Virginia Barciela González, Gabriel García Atiénzar, Mauro S. Hernández Pérez, Armando Llanos, Yolanda Carrión Marco, Isabel Beneyto, David López Serrano, Mario Sanz Tormo, António Carlos Valera, Concepción Blasco, Corina Liesau von Lettow‐Vorbeck, Patricia Ríos Mendoza, Joan Daura, María Jesús de Pedro Michó, Agustín Diez Castillo, Raúl Flores Fernández, Joan Francès i Farré, Rafael Garrido Peña, Victor S. Gonçalves, Elisa Guerra Doce, Ana Mercedes Herrero Corral, Joaquim Juan-Cabanilles, Dani López, Sarah B. McClure, Marta Pérez, Arturo Oliver Foix, Montserrat Sanz, Ana Catarina Sousa, Julio Manuel Vidal Encinas, Douglas J. Kennett, Martin Richards, Kurt W. Alt, Wolfgang Haak, Ron Pinhasi, Carles Lalueza‐Fox, David Reich,
Genomics of the Iberian Peninsula Ancient DNA studies have begun to help us understand the genetic history and movements of people across the globe. Focusing on the Iberian Peninsula, Olalde et al. report genome-wide data from 271 ancient individuals from Iberia (see the Perspective by Vander Linden). The findings provide a comprehensive genetic time transect of the region. Linguistics analysis and genetic analysis of archaeological human remains dating from about 7000 years ago to the present elucidate ...
Tópico(s): Archaeology and ancient environmental studies
2019 - American Association for the Advancement of Science | Science
Produção Nacional
Revisado por pares
Silvana Y. Romero‐Zerbo, María García‐Fernández, Vanesa Espinosa-Jiménez, Macarena Pozo‐Morales, Alejandro Escamilla, Lourdes Sánchez‐Salido, Estrella Lara, Nadia Cobo‐Vuilleumier, Alex Rafacho, Gabriel Olveira, Gemma Rojo‐Martínez, Benoit R. Gauthier, Isabel González‐Mariscal, Francisco J. Bermúdez‐Silva,
Background and Aims: The synthetic atypical cannabinoid Abn-CBD, a cannabidiol (CBD) derivative, has been recently shown to modulate the immune system in different organs, but its impact in obesity-related meta-inflammation remains unstudied. We investigated the effects of Abn-CBD on metabolic and inflammatory parameters utilizing a diet-induced obese (DIO) mouse model of prediabetes and non-alcoholic fatty liver disease (NAFLD). Materials and Methods: Ten-week-old C57Bl/6J mice were fed a high-fat ...
Tópico(s): Pancreatic function and diabetes
2020 - Frontiers Media | Frontiers in Endocrinology
Juan Jiménez‐Jáimez, Rosa Macías‐Ruiz, Francisco Bermúdez-Jiménez, Ricardo Rubini-Costa, Jessica Ramírez-Taboada, Paula Isabel García Flores, Laura Gallo-Padilla, Juan Diego Mediavilla García, Concepción Morales García, Sara Moreno Suárez, Celia Fignani Molina, Miguel Álvarez López, Luís Tercedor,
Abstract SARS-CoV-2 is a rapidly evolving pandemic causing great morbimortality. Medical therapy with hydroxicloroquine, azitromycin and protease inhibitors is being empirically used, with reported data of QTc interval prolongation. Our aim is to assess QT interval behaviour in a not critically ill and not monitored cohort of patients. We evaluated admitted and ambulatory patients with COVID-19 patients with 12 lead electrocardiogram at 48 h after treatment initiation. Other clinical and analytical ...
Tópico(s): ECG Monitoring and Analysis
2020 - Nature Portfolio | Scientific Reports
Isabel González‐Mariscal, Macarena Pozo‐Morales, Silvana Y. Romero-Zerbo, Vanesa Espinosa-Jiménez, Alejandro Escamilla, Lourdes Sánchez‐Salido, Nadia Cobo‐Vuilleumier, Benoit R. Gauthier, Francisco J. Bermúdez‐Silva,
The atypical cannabinoid Abn-CBD improves the inflammatory status in preclinical models of several pathologies, including autoimmune diseases. However, its potential for modulating inflammation in autoimmune type 1 diabetes (T1D) is unknown. Herein we investigate whether Abn-CBD can modulate the inflammatory response during T1D onset using a mouse model of T1D (non-obese diabetic- (NOD)-mice) and of beta cell damage (streptozotocin (STZ)-injected mice). Six-week-old female NOD mice were treated with ...
Tópico(s): Diet, Metabolism, and Disease
2021 - Elsevier BV | Biomedicine & Pharmacotherapy
José Alfonso Aguilar-Fuentes, Cruz García Lirios, Gilberto Bermúdez Ruíz, Minerva Isabel Pérez Ortega, Eyder Bolivar-Mojica, Sofía López de Nava Tapía, Francisco Espinoza Morales, Tirso Javier Hernández Gracia, Gabriel Pérez-Crisanto,
A model is a data management, production and transfer system organized in explanatory trends of past, current and future relationships. The emphasis on each suggests decision making and strategy execution. The objective of this work was to specify a model for of the perception of utility. An exploratory and cross-sectional study was conducted with a selection of 186 students from a public university in central Mexico, considering their participation in the system of professional practices and social ...
Tópico(s): Diverse Applied Research Studies
2019 - Forum XXI | Revista de Comunicación y Salud
Pastora Salinas‐Hernández, Francisco J. López‐Bermúdez, Damaris Rodríguez‐Barrientos, Marı́a Teresa Ramı́rez-Silva, M. Romero‐Romo, Fernando Morales‐Anzures, Alberto Rojas-Hernándéz,
The tree Eysenhardtia polystachya (Ortega) Sarg. has quite a wide popular use within the traditional Mexican medicine as herbal remedy. Popular practices constitute a relevant enough basis to design optimum analytical methods in order to determine basic principles of diverse medicinal plants. This has become one of the essentials needed to characterize such products, for which it is fundamentally important to develop an efficient and reliable separation method. This work presents the results concerning ...
Tópico(s): Analytical Chemistry and Chromatography
2008 - Wiley | Journal of Separation Science
Flor Selene Villalobos‐Escobedo, Rafael Jijón‐Lorenzo, José Arturo Ávalos‐Fuentes, Francisco Paz‐Bermúdez, Sergio Recillas‐Morales, Israel Conde Rojas, Gerardo Leyva‐Gómez, Hernán Cortés, Benjamín Florán,
Abstract Dopamine D2 receptor (D 2 R) is expressed in striatopallidal neurons and decreases forskolin‐stimulated cyclic adenine monophosphate (cAMP) accumulation and gamma‐aminobutyric acid (GABA) release. Dopamine D3 receptor (D 3 R) mRNA is expressed in a population of striatal D 2 R‐expressing neurons. Also, D 3 R protein and binding have been reported in the neuropil of globus pallidus. We explore whether D 2 R and D 3 R colocalize in striatopallidal terminals and whether D 3 R modulates the D 2 ...
Tópico(s): Neurological disorders and treatments
2023 - Wiley | European Journal of Neuroscience