Edouard Louis, Stefan Schreiber, Remo Panaccione, Peter Bossuyt, Luc Biedermann, Jean–Frédéric Colombel, Gareth M. B. Parkes, Laurent Peyrin‐Biroulet, Geert R. D’Haens, Hisamatsu Tadakazu, Britta Siegmund, Kaichun Wu, Brigid S. Boland, Gil Y. Melmed, Alessandro Armuzzi, Phillip Levine, Jasmina Kalabic, Su Chen, Ling Cheng, Lei Shu, W. Rachel Duan, Valerie Pivorunas, Yuri Sánchez González, Ronilda D’Cunha, Ezequiel Neimark, Kori Wallace, Raja Atreya, Marc Ferrante, Edward V. Loftus, Domingo Balderramo, Silvina A. Goncalves, Juan Lasa, Abel Novillo, Orlando Ruffinengo, Sonja Heeren, Walter Reinisch, Filip Baert, Peter Bossuyt, A Colard, Olivier Dewit, Marc Ferrante, Denis Franchimont, Edouard Louis, Jean–François Rahier, Carlos F. Francesconi, Roberto Luiz Kaiser, Rogério Serafim Parra, Lígia Yukie Sassaki, Пламен Пенчев, Desislav Stanchev, Kenneth Atkinson, Melanie Beaton, Talat Bessissow, Susan Greenbloom, Jean-Rene Lachance, Allen Lim, Remo Panaccione, Jean-Michel Samson, Scott Shulman, Jesse Siffledeen, Ignacio Alfaro, Carlos Valenzuela, Gustavo Walsen, Ping An, Qian Cao, Yan Chen, Youxiang Chen, Xiang Gao, Xiaohua Hou, Naizhong Hu, Yan Li, Fei Liu, Mei Liu, LU Lungen, Zhihua Ran, Tongyu Tang, Xin Wang, Shaoqi Yang, Qiang Zhan, Guoxin Zhang, Hu Zhang, Jie Zhang, Xiaolan Zhang, Jie Zhong, Xiaoping Zou, Eligio Álvarez, Juan Camilo Ricaurte, Vladimir Borzan, Željko Krznarić, Željko Puljiz, Martin Bortlík, Pavel Svoboda, Jan Ulbrych, Tomáš Vaňásek, Jens Kjeldsen, Lars Kristian Munck, Anja Poulsen, Ezzat Ali, Osama Salem, Hisham Sawah, Imam Waked, Romain Altwegg, Mathurin Flamant, Mathurin Fuméry, Xavier Hébuterne, David Laharie, Laurent Peyrin‐Biroulet, Xavier Roblin, Xavier Tréton, Raja Atreya, Herbert Deppe, Peter Hasselblatt, Arne Kandulski, Jochen Klaus, Thomas Krause, Torsten Kucharzik, Jessica Mertens, Michael Mroß, N. A. Naumann, Wolfgang Reindl, Ingolf Schiefke, Stefan Schreiber, Stefan Schubert, Britta Siegmund, Andreas Sturm, Georgios Bamias, Ioannis E. Κoutroubakis, Spilios Manolakopoulos, Gerassimos J. Mantzaris, Maria Tzouvala, N. Viazis, Irit Avni‐Biron, Eran Goldin, Lior H. Katz, Adi Lahat-Zok, Arik Segal, Sandro Ardizzone, Alessandro Armuzzi, Michele Cicala, Antonio Colecchia, R. Cosintino, Antonio Gasbarrini, Andrea Geccherle, Edoardo G. Giannini, Paolo Gionchetti, Francesco Luzza, Giovanni Monteleone, Antonino Carlo Privitera, Simone Saibeni, Marcello Vangeli, Yasuhiko Abe, Nobuo Aoyama, Kunio Asonuma, Yutaka Endo, Motohiro Esaki, Toshimitsu Fujii, Katsuyuki Fukuda, Fumihito Hirai, Yasuhiro Hisanaga, Noriyuki Horiki, Mikitaka Iguchi, K. Ishigami, Yoh Ishiguro, Hiroaki Ito, Yoichi Kakuta, Koji Kamikozuru, Jun Kato, Teruki Kawanishi, Taku Kobayashi, Hiroyuki Kuge, Atsuo Maemoto, Tomoyuki Masuda, Katsuyoshi Matsuoka, Kayoko Matsushima, Masashi Matsushima, Satoshi Motoya, Katsuhiko Nakai, Koichi Nakajima, Masanao Nakamura, Atsushi Nishida, Takahiro Nishikawa, Nobuaki Nishimata, Toshiaki Ochiai, Naoki Ohmiya, Yoshifumi Ohnishi, Shiro Oka, Keiji Ozeki, Daisuke Saito, Masayuki Saruta, Makoto Sasaki, Masahito Shimizu, Ken Sugimoto, Tomohisa Sujino, Takayoshi Suzuki, Hajime Takatori, Noritaka Takatsu, Hidetoshi Takedatsu, Ken Takeuchi, Hiroki Tanaka, Shizuo Tokito, Toshiyuki Endo, Tatsuya Toyokawa, Yoshito Uenoyama, Takatsugu Yamamoto, Takayuki Yamamoto, Hiroshi Yasuda, Kaoru Yokoyama, Aleksejs Derovs, Aldis Puķītis, Laimas Jonaitis, Edita Kazėnaitė, Lourdes Lol-be Pinzon Te, Geert R. D’Haens, Maurice Lutgens, James Brooker, Richard B. Gearry, B Griffiths, Stephen Inns, Michael Schultz, Jerzy Eszyk, Jarosław Kierkuś, D Kleczkowski, Adam Kopoń, Robert Petryka, Jarosław Reguła, Tomasz Romańczyk, Grażyna Rydzewska-Wyszkowska, Piotr Sikorski, Michał Talarek, Rute Cerqueira, Tiago Gonçalves, Susana Lopes, Paula Ministro, Francisco Portela, Helena Tavares, Mihai-Mircea Diculescu, Adrian Goldiș, Andrada Seicean, Alina Agafina, Anton Edin, Е. В. Герасимова, Maryana Gettueva, В. Н. Кашников, Albert Pirmagomedov, Vladimir Rafalskiy, К. М. Шарапова, Е. А. Smolyarchuk, D V Varganova, Saša Grgov, Igor Jovanović, Petar Svorcan, Dino Tarabar, Khoon Lin Ling, Jozef Baláž, J Ďurina, Miloš Greguš, Martin Laclav, David Drobne, Eduan Deetlefs, Jonny Peter, Muhammad Rajabally, Jennifer Rosa, JI van Zyl, John Wright, Jae Hee Cheon, Byung Ik Jang, Jee Hyun Kim, Sang-Bum Kang, Duk-Hwan Kim, Tae Oh Kim, Young-Ho Kim, Jong Hun Lee, Kang‐Moon Lee, Dong Il Park, Geun Am Song, Federico Argüelles‐Arias, Luisa Castro Laria, Ana Echarri, Santiago García‐López, Vincent Hernandez Ramirez, María Dolores Martín‐Arranz, Pilar Varela Trastoy, M Vera Mendoza, Mikael Lördal, Luc Biedermann, Benjamin Misselwitz, Chung-Hsin Chang, Jen‐Wei Chou, Chia-Jung Kuo, Ching‐Pin Lin, Chia–Hung Tu, Hüseyin Alkım, Yusuf Erzın, İrfan Soykan, Tetiana Kravchenko, Nataliia Tsarynna,
Importance The clinical effects of risankizumab (a monoclonal antibody that selectively targets the p19 subunit of IL-23) for the treatment of ulcerative colitis are unknown. Objective To evaluate the efficacy and safety of risankizumab when administered as an induction and a maintenance therapy for patients with ulcerative colitis. Design, Setting, and Participants Two phase 3 randomized clinical trials were conducted. The induction trial was conducted at 261 clinical centers (in 41 countries) and ...
American Medical Association
Miguel A. Martín-Acebes, Mónica González-Magaldi, María F. Rosas, Belén Borrego, Emiliana Brocchi, Rosario Armas-Portela, Francisco Sobrino,
The intracellular distribution of swine vesicular disease virus (SVDV) proteins and the induced reorganization of endomembranes in IBRS-2 cells were analyzed. Fluorescence to new SVDV capsids appeared first upon infection, concentrated in perinuclear circular structures and colocalized to dsRNA. As in foot-and-mouth disease virus (FMDV)-infected cells, a vesicular pattern was predominantly found in later stages of SVDV capsid morphogenesis that colocalized with those of non-structural proteins 2C, ...
Tópico(s): Animal Virus Infections Studies
2008 - Elsevier BV | Virology
Produção Nacional
Revisado por pares
Vilma Lima, Francisco Daniel Portela Vidal, Francisco Airton Castro Rocha, Gerly Anne de Castro Brito, Ronaldo A. Ribeiro,
Background: Pentoxifylline (PTX) and thalidomide (TLD) have been shown to inhibit cytokine synthesis, mainly tumor necrosis factor (TNF)‐α, in different inflammatory conditions. We studied the effects of these cytokine inhibitors in an experimental model of periodontitis. Methods: Wistar rats were subjected to a ligature placement around the second upper right molars. Alveolar bone loss was evaluated by the sum of the distances between the cusp tip and the alveolar bone along the axis of each molar ...
Tópico(s): Microbial infections and disease research
2004 - Wiley | Journal of Periodontology
Produção Nacional
Revisado por pares
Vilma Lima, Mirna Marques Bezerra, Veruska Bezerra De Menezes Alencar, Francisco Daniel Portela Vidal, Francisco Airton Castro Rocha, Gerly Anne de Castro Brito, Ronaldo de Albuquerque Ribeiro,
Chlorpromazine (CPZ), a phenothiazine derivative, possesses anti‐inflammatory properties, inhibition of tumor neurosis factor‐α(TNF‐α) synthesis and bone resorption. TNF‐α promotes inflammatory changes and bone resorption in periodontitis. We have studied the effect of CPZ in experimental periodontitis. Wistar rats were subjected to a ligature placement around the cervix of the right second upper molars. Alveolar bone loss was evaluated by the sum of the distances between the cusp tip and the alveolar ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
2000 - Wiley | European Journal Of Oral Sciences
J. H. Maner, W. G. Pond, J. T. Gallo, Agudelo Henao, R. Portela, Francisco Linares,
One experiment was completed with 56 weanling Duroc × Landrace × Yorkshire swine and two with weanling Sprague-Dawley rats to determine the nutritive value of Colombian floury-2 corn in comparison with that of Colombian opaque-2 and Colombian common corn. In both rats and swine Colombian floury-2 corn (both male and female) was inferior to opaque-2 corn and similar to common corn when daily gain and feed/gain were the criteria of response. In rats, the PER obtained with floury-2 corn was also inferior ...
Tópico(s): Animal Nutrition and Physiology
1971 - Oxford University Press | Journal of Animal Science
Rubén Tarrío, J.J Cuenca, Valdemar Marques Gomes, Vicente Campos, José María Herrera, Fernando Rodríguez‐Rodríguez, José Vicente González Valle, Francisco Portela, Javier García-Carro, Belén Adrio, Francisco Vega, Alberto Juffé,
Off-pump coronary artery bypass grafting with both the internal thoracic arteries, such as the Tector technique, can reduce the morbidity associated with extracorporeal circulation and aortic cross-clamp. The aim of the present study is to describe our experience and the results obtained.From April 1998 to December 2003, the off-pump Tector technique was performed on 743 patients, of whom 621 were male (83.5%), with a mean age of 65.3 +/- 9.5 years (23-90). Preoperative risk factors were diabetes mellitus ...
Tópico(s): Coronary Interventions and Diagnostics
2004 - Wiley | Journal of Cardiac Surgery
Eugeni Domènech, Julián Panés, Joaquín Hinojosa, Vito Annese, Fernando Magro, Giacomo Carlo Sturniolo, Fabrizio Bossa, F. FERNÁNDEZ, Benito González-Conde, Valle García–Sánchez, Axel Dignaß, José M. Herrera, José Luis Cabriada, Jordi Guardiola, Maurizio Vecchi, Francisco Portela, Daniel Ginard, Luis Abreu, Xavier Aldeguer, Montserrat Andreu, Vito Anesse, Juan Ignacio Arenas, Daniel C. Baumgart, Manuel Barreiro–de Acosta, Stephan H. Böhm, Fabrizzio Bossa, José Luis Cabriada, Félix Calvo, Fernando Carballo, Xavier Cortés, Silvio Danese, Axel Dignaß, Eugeni Domènech, María Esteve, F. FERNÁNDEZ, Esther García-Planella, Bastianello Germanà, Daniel Ginard, B González, Federico Gómez-Camacho, Jordi Guardiola, Ana Gutiérrez, José M. Herrera, Vicent Hernández, Joaquín Hinojosa, Paula Lago, Fernando Magro, Míriam Mañosa, José Miguel Marrero, Paula Ministro, Fernándo Muñoz, Francesco Pallone, Julián Panés, Jóse Lázaro Pérez-Calle, Francisco Portela, Walter Reinisch, Giacomo Carlo Sturniolo, Carlos Taxonera, Narcís Vázquez, Maurizio Vecchi,
Steroid-dependency occurs in up to 30% of patients with ulcerative colitis [UC]. In this setting, few drugs have demonstrated efficacy in inducing steroid-free remission. The aim of this study was to evaluate the efficacy and safety of adding granulocyte/monocyte apheresis [GMA] to oral prednisone in patients with steroid-dependent UC.This was a randomized, multicentre, open trial comparing 7 weekly sessions of GMA plus oral prednisone [40 mg/day and tapering] with prednisone alone, in patients with ...
Tópico(s): Liver Diseases and Immunity
2018 - Oxford University Press | Journal of Crohn s and Colitis
Miguel A. Martín-Acebes, Mónica González-Magaldi, Ángela Vázquez-Calvo, Rosario Armas-Portela, Francisco Sobrino,
We performed a comparative analysis of the internalization mechanisms used by three viruses causing important vesicular diseases in animals. Swine vesicular disease virus (SVDV) internalization was inhibited by treatments that affected clathrin-mediated endocytosis and required traffic through an endosomal compartment. SVDV particles were found in clathrin-coated pits by electron microscopy and colocalized with markers of early endosomes by confocal microscopy. SVDV infectivity was significantly ...
Tópico(s): Viral Infectious Diseases and Gene Expression in Insects
2009 - American Society for Microbiology | Journal of Virology
Miguel Areia, Susana Alves, Daniel Brito, Ana Teresa Cadime, Rita Carvalho, Sandra Saraiva, Sara Ferreira, Joana Moleiro, António Dias Pereira, J Carrasquinho, Luís Lopes, José María Ramada, Ricardo Marcos‐Pinto, Isabel Pedroto, Luís Contente, Liliana Eliseu, A.M. Vieira, Margarida Sampaio, Helena Tavares de Sousa, Nuno Almeida, Carlos Gregório, Francisco Portela, Carlos Sofia, V. Braga, Elisabete Baginha, Tiago Costa, Cristina Chagas, Luís Lebre Mendes, Pedro Magalhães-Costa, Leopoldo Matos, Francisco Rocha Gonçalves, Mário Dinis‐Ribeiro,
Background & Aims: A recent review of economic studies relating to gastric cancer revealed that authors use different tests to estimate utilities in patients with and without gastric cancer. Our aim was to determine the utilities of gastric premalignant conditions and adenocarcinoma with a single standardized health measure instrument.Methods: Cross-sectional nationwide study of patients undergoing upper endoscopy (n=1,434) using the EQ-5D-5L quality of life (QoL) questionnaire.Results: According to ...
Tópico(s): Gastric Cancer Management and Outcomes
2014 - Editura Medicală Universitară Iuliu Hatieganu | Journal of Gastrointestinal and Liver Diseases
Produção Nacional
Revisado por pares
Mariana Servín-Pastor, Renato Portela Salomão, Francisco Caselín-Cuevas, Alex Córdoba‐Aguilar, Mario E. Favila, Alberto Jácome-Hernández, Daniel Lozano-Sánchez, Daniel González‐Tokman,
Ecosystem services relies on several insects that provide fundamental functions. Despite the quality of these ecosystem services depends on insect diversity, abundance and biomass, little is known about the effects that individual body condition has over such services. One prediction is that starving or sick animals may provide a reduced service. Dung beetles bury dung in forests and cattle farms, contributing to soil fertilization and reduction of greenhouse gas emissions from livestock. However, ...
Tópico(s): Insect Utilization and Effects
2020 - Elsevier BV | Ecological Indicators
Laurent Peyrin‐Biroulet, Jessica R. Allegretti, David T. Rubin, Brian Bressler, Matthew Germinaro, Kuan-Hsiang Gary Huang, Nicole Shipitofsky, Hongyan Zhang, Rebbecca Wilson, Chenglong Han, Brian G. Feagan, William J. Sandborn, Julián Panés, Tadakazu Hisamatsu, Gary R. Lichtenstein, Bruce E. Sands, Axel Dignaß, О. Аbrahamovych, Halyna Afanasieva, Lilia Aitova, Engin Altıntaş, Romain Altwegg, П. С. Андреев, Kazuki Aomatsu, Monika Augustyn, Paola Balestrieri, Jakob Begun, Luciana Brunatto, Diego Bulgheroni, Elena Bunkova, Mercedes Cabello, Qian Cao, Flavio Caprioli, Rute Cerqueira, Baili Chen, Chou‐Chen Chen, Chou-Pin Chen, Cheng‐Tang Chiu, Chang Hwan Choi, Michele Cicala, Olena Datsenko, Pieter Dewint, Eugeni Domènech, Joris Dutré, George Duvall, J. C. Fernández, Rafał Filip, Ronald Fogel, Sharyle Fowler, Toshimitsu Fujii, Masayuki Fukata, Yohei Furumoto, Antonio Gasbarrini, Beata Gawdis-Wojnarska, Cyrielle Gilletta, Paolo Gionchetti, Eran Goldin, Oleksandr Golovchenko, Maciej Gonciarz, Can Gönen, Gaston Gonzalez Segura, Oleksii Gridnyev, T Gyökeres, Xavier Hébuterne, Charlotte Hedin, Per M. Hellström, Ida Hilmi, Ivo Horný, Gyula Horvat, Namiko Hoshi, Luděk Hrdlička, Shunji Ishihara, Olha Ivanishyn, Byung Ik Jang, Odery Ramos, Takashi Kagaya, Shuji Kanmura, Marina Karakina, Nakai Katsuhiko, Jarosław Kierkuś, Hyo Jong Kim, Tae Oh Kim, Young‐Ho Kim, G Kiss, Jochen Klaus, D Kleczkowski, Maria Kłopocka, Taku Kobayashi, Iwona Kobielusz-Gembala, Ja Seol Koo, Adam Kopoń, Tetiana Kravchenko, Masatoshi Kudo, Kwang An Kwon, Paula Lago, David Laharie, Ian C. Lawrance, Jarosław Leszczyszyn, Yan Li, Milan Lukáš, Christian Maaser, Atsuo Maemoto, Hiroyuki Marusawa, Matthew J. McBride, Shoba Mendu, Pál Miheller, Hideharu Miyabayashi, W Mohl, Gregory Moore, Satoshi Motoya, Narayanachar Murali, Mohammed Al Naem, Koichi Nakajima, Yasunari Nakamoto, Stéphane Nancey, Joaquim Isquierdo Quadrado Neto, Michio Onizawa, Yohei Ono, Yohei Ono, Taro Osada, М. Ф. Осипенко, Danuta Owczarek, Bhaktasharan Patel, Kamal Patel, Elina Petrova, Е Г Порошина, Francisco Portela, Lyudmyla Prystupa, Montserrat Rivero, Xavier Roblin, J Romatowski, Grażyna Rydzewska, Simone Saibeni, Hirotake Sakuraba, Mark Samaan, Michael Schultz, J Schulze, Shahriar Sedghi, Ursula Seidler, Sung Jae Shin, Mykola Stanislavchuk, David Stokesberry, Takayoshi Suzuki, Hiroki Taguchi, Lyudmila Tankova, Lena Thin, Tkachev Av, Leyanira Torrealba, Nataliia Tsarynna, Zsolt Tulassay, Tetsuya Ueo, Ekaterina Valuyskikh, Olga Vasilevskaya, Manuel Viamonte, Shu‐Chen Wei, Roni Weisshof, Katarzyna Wójcik‐Pszczoła, Byong Duk Ye, Hsu–Heng Yen, Hyuk Yoon, Kosuke Yoshida, Andriy Yurkiv, Osamu Zaha, Qiang Zhan,
The QUASAR Phase 2b Induction Study evaluated the efficacy and safety of guselkumab, an interleukin-23p19 subunit antagonist, in patients with moderately to severely active ulcerative colitis (UC) with prior inadequate response and/or intolerance to corticosteroids, immunosuppressants, and/or advanced therapy.
Tópico(s): Dermatology and Skin Diseases
2023 - Elsevier BV | Gastroenterology
Laurent Peyrin‐Biroulet, Jean‐François Rahier, Julien Kirchgesner, Véred Abitbol, Sebastian Shaji, Alessandro Armuzzi, Konstantinos Κarmiris, Javier P. Gisbert, Peter Bossuyt, Ulf Helwig, Johan Burisch, Henit Yanai, Glen A. Doherty, Fernando Magro, Tamás Molnár, Mark Löwenberg, Jonas Halfvarson, Edyta Zagórowicz, Hélène Rousseau, Cédric Baumann, Filip Baert, Laurent Beaugerie, Jean‐Marc Gornet, Laurent Beaugerie, Sebastian Shaji, Laurent Peyrin‐Biroulet, Jean‐Marie Reimund, Xavier Hébuterne, Aurélien Amiot, Franco Armelao, Pierre Blanc, Claudio Papi, Guillaume Pineton de Chambrun, Xavier Roblin, Michael J. J. Chu, Konstantinos Κarmiris, Sohail Shariq, N. Viazis, Jimmy K. Limdi, Piotr Eder H, Georgios Michalopoulos, A. S. Bell, Livia Biancone, Marie Dewitte, Zia Mazhar, Denis Franchimont, Stéphane Nancey, Gilles Macaigne, Mariabeatrice Principi, Mathurin Fuméry, Gareth Parkes, Jean-Christophe Valats, Glen A. Doherty, Guillaume Bouguen, Tamás Molnár, Hersin Tsai, Mohsin Gangi, Natalia Pedersen, Frédéric Heluwaert, Richard Shenderey, Sebastian Zeißig, Jeffrey Butterworth, Fabiana Castiglione, Lynsey Corless, Camille Zallot, Filip Baert, Salil Singh, Sunil Sonwalkar, Elizabeth Clayton, Jean‐François Rahier, Deven Vani, Guy Bellaïche, Martine De Vos, Julien Kirchgesner, Uri Kopylov, Triana Lobatón, Christophe Locher, Gerassimos J. Mantzaris, George Abouda, Katie Smith, Michael Sprakes, Anǵeliki Theodoropoulou, Emma Wesley, Joëlle Bonnet, David Elphick, Cyrielle Gilletta, John Gordon, David Laharie, A. Nakad, Ambrogio Orlando, Patrick Dubois, Peter Hasselblatt, Christophe Michiels, Cathryn Preston, Anca Staicu, Lucine Vuitton, Mehdi Kaassis, Ally Speight, Deb Ghosh, Mark Löwenberg, Nicolas Mathieu, Anne-Laure Pelletier, Anne Phillips, Fernando Magro, Romain Altwegg, Irit Avni, biron, Jonathon Landy, Maria Nachury, Achuth Shenoy, Caroline Trang, Véred Abitbol, Georgios Bamias, Klaudia Farkas, Christian Maaser, Ariella Bar‐Gil Shitrit, Britta Siegmund, Jérôme Filippi, Colm OʼMorain, Henit Yanai, Laurent Costes, David Hobday, Zoltán Szepes, Emma Calabrese, Helen Dallal, Michael Fung Kee Fung, Arvind Ramadas, Bijay Baburajan, Konrad Koss, Christophe Barberis, Anthony Buisson, Morgane Amil, Paola Balestrieri, Matthew Johnson, Maria Tzouvala, S Viennot, Ferenc Nagy, Nick Thompson, Laurent Alric, Sunil Samuel, Anne Bourrier, Elise Chanteloup, Émilie Del Tedesco, Marcus Harbord, Alan Lobo, Sally Myers, Richard Pollok, Tariq Ahmad, Rubina Chaudhary, Christos Karakoidas, Ashraf Soliman, Carmen Stefănescu, Georgios Theocharis, S Vanden Branden, Belén Beltrán, Yoram Bouhnik, Arnaud Bourreille, Joana C. Branco, Ben Colleypriest, Rami Eliakim, Paul R. Knight, Aoibhlinn O’Toole, Virgina Robles, Konstantinos Triantafyllou, Marta Maia Bosca‐Watts, Guy Lambrecht, Lucia Marquez Mosquera, Simon Panter, Aikaterini Pappa, Marion Simon, Ganesh Sivaji, Christophe Bellanger, Arthur Belle, Natalia Borruel, Laurence J. Egan, Harald Peeters, D Sharpstone, Ramesh Arasaradnam, José Manuel Benitez, Jens Frederik Dahlerup, Όλγα Γιουλεμέ, Javier P. Gisbert, Ulf Helwig, Miguel Mínguez, Eftychia Tsironi, Angela Variola, Patrick B. Allen, Lucille Boivineau, Andy Cole, Nina Dib, Fernando Gomollón, Richard L. Johnston, Κωνσταντίνος Κατσάνος, Nicholas A. Kennedy, Marianne Kiszka‐Kanowitz, Ignacio Marín‐Jiménez, Pál Miheller, Pilar Nos, Othman Saraj, Lars Vinter‐Jensen, Eran Zittan, Clotilde Baudry, Xavier Calvet, Marie-Christine Cazelles-Boudier, J L Coenegrachts, Garret Cullen, Marco Daperno, Anjan Dhar, Romain Gérard, Nanna M. Jensen, Nitsan Maharshak, Mark E. McAlindon, Simon Mcloughlin, Miles Parkes, Kamal Patel, Armando Peixoto, Dimitrios Polymeros, Francisco Portela, Rodolfo Rocca, Philippe Marteau, Sreedhar Subramanian, Ruth Tennenbaum, Raja Atreya, Oliver Bachmann, Arthur Berger, Renáta Bor, Maire Buckley, Daniel Carpio, María Chaparro, Francesco Costa, Eugeni Domènech, María Esteve, Stephen F. Foley, Jordi Guardiola, Ioannis Ε. Koutroubakis, Tanja Kuehbacher, Cécilia Landman, A. Lavagna, Noemí Manceñido, Míriam Mañosa, María Dolores Martín‐Arranz, Laurianne Plastaras, Maria Lia Scribano, Subhasish Sengupta, Nils Teich, My‐Linh Tran‐Minh, Evanthia Zampeli, Leila Amininejad, Teresa Arroyo, Alain Attar, A Bäckman, Anita Bálint, John Beckly, Shomron Ben‐Horin, Sónia Bernardo, Ludovic Caillo, Bénédicte Caron, María Shanika de Silva, Anna Fábián, Gionata Fiorino, Ana Gutiérrez, Adi Lahat, Mohamed Masmoudi, Marco Mendolaro, Vinciane Muls, Florian Poullenot, C Probert, Cathérine Reenaers, Mariann Rutka, Zaman Sarwari, Joanne Sayer, Beatriz Sicilia, Helena Tavares de Sousa, Catherine Van Kemseke, Yamile Zabana, Marco Astegiano, Paul R. Banim, Dominik Bettenworth, Médina Boualit, Jacob Broder Brodersen, Angeliki Christidou, Rachel Cooney, João Cortez Pinto, Portugal Marília Cravo, Anneline Cremer, Silvio Danese, Antonio Di Sabatino, Jan Fallingborg, Antonio Ferronato, Esther Garcia Planella, Sanjay Gupta, Jonas Halfvarson, Eran Israeli, Samantha Kestenbaum, Lone Larsen, Elisabeth Macken,
There is a need to evaluate the benefit-risk ratio of current therapies in inflammatory bowel disease (IBD) patients to provide the best quality of care. The primary objective of I-CARE (IBD Cancer and serious infections in Europe) was to assess prospectively safety concerns in IBD, with specific focus on the risk of cancer/lymphoma and serious infections in patients treated with anti-tumor necrosis factor and other biologic monotherapy as well as in combination with immunomodulators.I-CARE was designed ...
Elsevier BV
Samuel Fernandes, Juliana Serrazina, I Botto, Tiago Leal, Andreia Guimarães, Joana Lemos Garcia, Isadora Rosa, Rita Prata, Diana Carvalho, João A. Cunha Neves, Pedro Henrique Campelo, Sofia Ventura, Andrea Silva, Mariana Coelho, Cristiana Sequeira, Ana Paula Oliveira, Francisco Portela, Paula Ministro, Helena Tavares de Sousa, Jaime Ramos, Isabel Claro, Raquel Gonçalves, L Correia, Rui Tato Marinho, Helena Cortez‐Pinto, Fernando Magro,
Evidence supporting transmural remission (TR) as a long-term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long-term.Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five-year rates of hospitalization, surgery, use of steroids, and treatment escalation were compared between ...
Tópico(s): Diagnosis and treatment of tuberculosis
2022 - Wiley | United European Gastroenterology Journal
Silvio Danese, Séverine Vermeire, Geert R. D’Haens, Julián Panés, Axel Dignaß, Fernando Magro, Maciej Nazar, Manuela Le Bars, Marjolein Lahaye, Lioudmila Ni, Ivana Bravatà, F. Lavie, Marco Daperno, Milan Lukáš, Alessandro Armuzzi, Mark Löwenberg, Daniel R. Gaya, Laurent Peyrin‐Biroulet, Rodolfo Rocca, Susana Lopes, Flavio Caprioli, Sandro Ardizzone, Ana Echarri, Paolo Gionchetti, Xavier Roblin, Ursula Seidler, David Andersson, Kamal Patel, Pierre Desreumaux, Simone Saibeni, Gustav From, Miroslav Fedurco, Miloš Greguš, Yoram Bouhnik, Andreas Luegering, R. Cosintino, Ivan Bunganič, Jaime A. Ramos, Mariam Aguas Peris, Olivier Dewit, Mariabeatrice Principi, Emma Wesley, Paula Lago, Stéphane Nancey, María Dolores Martín‐Arranz, P. Hindryckx, Ambrogio Orlando, Andrea Geccherle, Maria Laura Annunziata, Bu Hayee, Jozef Baláž, Francisco Portela, Cyrielle Gilletta, Torsten Kucharzik, Miguel Mínguez, Javier P. Gisbert, Ana Gutiérrez, Édouard Louis, Marco Marino, Gareth M. B. Parkes, Fraser Cummings, Bindia Jharap, Jens Kjeldsen, L Correia, Paula Ministro, Matthias Ebert, Erik Hertervig, Dirk Staessen, Joris Dutré, A Colard, Graham Morrison, Henning Glerup, Jens Frederik Dahlerup, Frank H.J. Wolfhagen, M Bátovský, Martin Molnar, Barbora Kadleckova, Paulo Caldeira, David Laharie, Xavier Hébuterne, Bruno Bonaz, Matthieu Allez, Andreas Fischer, Joaquín Ernesto Hinojosa Del Val, M Mañosa Círia, José Manuel Herrera Justiniano, Charlotte Söderman, Rajiv Chandy, Craig Mowat, Peter M. Irving, Jan Fallingborg, Jan Matouš, Tomáš Douda, Romain Altwegg, J M Benítez, M Arroyo, Jordi Guardiola, Daniel Ginard Vicenc, Pieter Dewint, Sven Almér, Sébastien Kindt,
A treat-to-target strategy, in which strictly defined treatment targets facilitate decision making in clinical practice, is advocated as an optimised management approach for some chronic disorders. The aim of the STARDUST trial was to assess whether a treat-to-target strategy with early endoscopy, regular biomarker and clinical symptom monitoring, and dose intensification for persistent inflammatory activity, was more successful in achieving endoscopic improvement at week 48 than a clinically driven ...
Tópico(s): Microscopic Colitis
2022 - Elsevier BV | The Lancet. Gastroenterology & hepatology
Silvio Danese, Jean‐Frédéric Colombel, Milan Lukáš, Javier P. Gisbert, Geert R. D’Haens, Bu Hayee, Remo Panaccione, Hyun‐Soo Kim, Walter Reinisch, Helen E.J. Tyrrell, Young S. Oh, Swati Tole, Akiko Chai, Kirsten Chamberlain-James, Meina Tang, Stefan Schreiber, Nazimuddin Aboo, Tariq Ali Ahmad, Xavier Aldeguer Manté, Matthieu Allez, Sven Almér, Romain Altwegg, Montserrat Andreu García, Ramesh Arasaradnam, Sandro Ardizzone, Alessandro Armuzzi, Ian Arnott, Guy Aumais, Irit Avni‐Biron, Peter Barrow, Ian Beales, Fernando Bermejo San José, Abraham F. Bezuidenhout, Livia Biancone, Michael Blaeker, Stuart Bloom, Bernd Bokemeyer, Fabrizio Bossa, Peter Bossuyt, Guillaume Bouguen, Yoram Bouhnik, Gerd Bouma, Raymond Bourdages, Arnaud Bourreille, Christian Boustière, Tomáš Brabec, Stephan Brand, Carsten Buening, Anthony Buisson, Guillaume Cadiot, Xavier Calvet, Franck Carbonnel, Daniel Carpio, Jae Hee Cheon, Naoki Chiba, Camelia Chioncel, Nicoleta-Claudia Cimpoeru, Martin Clodi, Gino Roberto Corazza, R. Cosintino, José Cotter, Thomas Creed, Fraser Cummings, Silvio Danese, Gian Luigi De’ Angelis, Marc De Maeyer, Milind Y. Desai, Étienne Désilets, Pierre Desreumaux, Olivier Dewit, Geert R. D’Haens, Johanna Dinter, Ecaterina Daniela Dobru, Tomáš Douda, Dan L. Dumitraşcu, Matthias Ebert, Ana Echarri, Magdy Elkhashab, Chang Soo Eun, Brian G. Feagan, R Fejes, Catarina Fidalgo, Sigal Fishman, Bernard Flourié, Sharyle Fowler, Walter Fries, Csaba Fülöp, Mathurin Fuméry, G Kiss, Sonja Gassner, Daniel R. Gaya, Bastianello Germanà, Liliana Gheorghe, Cyrielle Gilletta, Paolo Gionchetti, Adrian-Eugen Goldis, Raquel Gonçalves, Jean–Charles Grimaud, T Gyökeres, Hervé Hagège, Andrei Haidar, Heinz Hartmann, Peter Hasselblatt, Bu Hayee, Xavier Hébuterne, Per M. Hellström, P. Hindryckx, Helena Hlavova, Frank Hoentjen, Stefanie Howaldt, Luděk Hrdlička, Kyu Chan Huh, Maria Isabel Iborra Colomino, Florentina Ioniţă‐Radu, Peter M. Irving, Jørgen Jahnsen, Byung-Ik Jang, Jeroen P. Jansen, Seong Woo Jeon, Rodrigo Jover Martínez, Pascal Juillerat, Per Karlén, Arthur Kaser, Radan Keil, Deepak Kejariwal, Dan Keret, Reena Khanna, Dong‐Woo Kim, Duk Hwan Kim, Hyo Jong Kim, Hyun‐Soo Kim, Joo Sung Kim, Kueongok Kim, Kyung-Jo Kim, Sung Kook Kim, Young‐Ho Kim, Jochen Klaus, Anna Kohn, Vladimír Kojecký, Ja Seol Koo, Robert Kozak, Milan Kremer, Tünde Kristóf, Frederik Cornelius Kruger, David Laharie, Adi Lahat-Zok, E. Landa, Jong Hun Lee, Kang‐Moon Lee, Kook Lae Lee, Yoojin Lee, Frank Lenze, Wee Chian Lim, Jimmy K. Limdi, James O. Lindsay, Pilar López Serrano, Édouard Louis, Stefan Lueth, Milan Lukáš, Giovanni Maconi, Fazia Mana, Steven Mann, John Mansfield, Santino Marchi, Marco Marino, John K. Marshall, María Dolores Martín‐Arranz, Bogdan Mateescu, John McLaughlin, Simon D. McLaughlin, Ehud Melzer, Jessica Mertens, Paul Mitruț, Tamás Molnár, Vinciane Muls, Pushpakaran Munuswamy, Charles Murray, Timna Naftali, Visvakuren Naidoo, Yusuf Nanabhay, Lucian Negreanu, Augustin Nguyen, Thomas Ochsenkuehn, Ambrogio Orlando, Remo Panaccione, Julián Panés Díaz, Maya Paritsky, Dong Il Park, Jihye Park, Luca Pastorelli, Markus Peck‐Radosavljevic, Farhad Peerani, Javier P. Gisbert, Laurent Peyrin‐Biroulet, Laurence Picon, Marieke Pierik, Terry Ponich, Francisco Portela, Maartens Jeroen Prins, I Rácz, Khan Fareed Rahman, Jean‐Marie Reimund, Max Reinshagen, Xavier Roblin, Rodolfo Rocca, Francesca Rogai, Gerhard Rogler, Á Salamon, Ennaliza Salazar, Zoltán Salló, Sunil Samuel, Miquel de los Santos Sans Cuffi, Edoardo Savarino, Vincenzo Savarino, Guillaume Savoye, Stefan Schreiber, Andrada Seicean, Christian P. Selinger, David Martins Serra, Hang Hock Shim, Sung Jae Shin, Britta Siegmund, Jesse Siffledeen, Wayne M Simmonds, Jan Šmíd, Jose D. Sollano, Geun Am Song, Alexander Speight, Ioan Sporea, Dirk Staessen, George Stancu, Alan Steel, David Stepek, Victor Stoica, Andreas Sturm, Gyorgy Szekely, Teck Kiang Tan, Carlos Taxonera, John Thomson, Michal Tichý, Gábor Tamás Tóth, Zsolt Tulassay, Marcello Vangeli, Márta Varga, Ana Paula Vieira, Stéphanie Viennot, Erica Villa, Petr Vítek, Harald Vogelsang, P Vyhnálek, Peter J. Wahab, Jens Walldorf, Byong Duk Ye, Christopher Ziady,
Background Etrolizumab is a gut-targeted anti-β7 integrin monoclonal antibody. In a previous phase 2 induction study, etrolizumab significantly improved clinical remission versus placebo in patients with moderately to severely active ulcerative colitis. We aimed to compare the safety and efficacy of etrolizumab with infliximab in patients with moderately to severely active ulcerative colitis. Methods We conducted a randomised, double-blind, double-dummy, parallel-group, phase 3 study (GARDENIA) across ...
Tópico(s): Celiac Disease Research and Management
2021 - Elsevier BV | The Lancet. Gastroenterology & hepatology
Fernando Magro, Catarina Alves, Joanne Lopes, Susana Lopes, Helena Tavares de Sousa, José Cotter, Vitor Macedo da Silva, Paula Lago, Ana Vieira, Mariana Brito, Maria Antónia Duarte, Francisco Portela, João P. Silva, Paula Ministro, Bruno Arroja, Liliana Carvalho, Joana Torres, Mafalda Santiago, María Manuela Estevinho, Silvio Danese, Laurent Peyrin‐Biroulet, Cláudia Camila Dias, Paula Borralho, Roger Feakins, Fátima Carneiro,
Background & AimsIn addition to findings from endoscopy, histologic features of colon biopsies have been associated with outcomes of patients with ulcerative colitis (UC). We investigated associations between Geboes scores (a system to quantify structural changes and inflammatory activity in colon biopsies) and UC progression, and the time period over which this association is valid.MethodsWe analyzed data from 399 asymptomatic patients with UC enrolled in the ACERTIVE study, followed at 13 inflammatory ...
Tópico(s): Diverticular Disease and Complications
2020 - Elsevier BV | Clinical Gastroenterology and Hepatology
Fernando Magro, Joanne Lopes, Paula Borralho, Susana Lopes, Rosa Coelho, José Cotter, Francisca Dias de Castro, Helena Tavares de Sousa, Marta Salgado, Patrícia Andrade, Ana Vieira, Pedro Figueiredo, Paulo Caldeira, Ana Sousa, Maria Antónia Duarte, Filipa Ávila, João S. Silva, Joana Moleiro, Sofia Mendes, Sílvia Giestas, Paula Ministro, Paula Sousa, Raquel Gonçalves, Bruno Gonçalves, Ana Oliveira, Cristina Chagas, Marília Cravo, Cláudia Camila Dias, Joana Afonso, Francisco Portela, Mafalda Santiago, Karel Geboes, Fátima Carneiro,
The histological status of ulcerative colitis [UC] patients in clinical and endoscopic remission has gained space as an important prognostic marker and a key component of disease monitoring. Our main aims were to compare two histological indexes-the continuous Geboes score [GS] and the Robarts Histopathology index [RHI]-regarding their definitions of histological remission and response, and the ability of faecal calprotectin [FC] levels to discriminate between these statuses.This was an analysis of ...
Tópico(s): Colorectal Cancer Surgical Treatments
2019 - Oxford University Press | Journal of Crohn s and Colitis
Stefano Urso, Eliú Nogales, Jesús María González‐Martín, Rafael Sádaba, María Ángeles Tena, Raquel Bellot, Luis A. Ríos, Francisco Portela,
The lack of benefit in terms of mid-term survival and the increase in the risk of sternal wound complications published in a recent randomized controlled trial have raised concerns about the use of bilateral internal thoracic artery (BITA) in myocardial revascularization surgery. For this reason, we decided to explore the current evidence available on the subject by carrying out a meta-analysis of propensity score-matched studies comparing BITA versus single internal thoracic artery (SITA). PubMed, ...
Tópico(s): Aortic Disease and Treatment Approaches
2019 - Oxford University Press | Interactive Cardiovascular and Thoracic Surgery
Joana Roseira, Fernando Magro, Samuel Fernandes, Carolina Simões, Francisco Portela, Ana Vieira, Marta Patita, Carina Leal, Paula Lago, Paulo Caldeira, Tânia Gago, Pedro Currais, Cláudia Camila Dias, Mafalda Santiago, Sandra Fernandes Dias, Helena Tavares de Sousa,
The impact of inflammatory bowel disease (IBD) on sexual health is a leading concern among patients. Most studies focus on sexual dysfunction rather than patient-perceived sexual quality of life (SQoL). We aimed to assess SQoL in IBD patients compared with healthy controls.This is a multicenter, cross-sectional study of IBD patients (n = 575 with Crohn's disease and n = 294 with ulcerative colitis), compared with healthy controls (n = 398), that used an anonymous self-administered questionnaire. This multimodal ...
Tópico(s): Endometriosis Research and Treatment
2019 - Oxford University Press | Inflammatory Bowel Diseases
María Manuela Estevinho, Cátia Rocha, Luís Correia, Paula Lago, Paula Ministro, Francisco Portela, Eunice Trindade, Joana Afonso, Laurent Peyrin‐Biroulet, Fernando Magro,
We performed a systematic review of changes in fecal and colon microbiomes of patients with inflammatory bowel diseases (IBDs) receiving treatment with monoclonal antibodies against tumor necrosis factor, integrins, or cytokines. We explored associations among microbiome composition and functions (at baseline and throughout the treatment) and therapy-related outcomes to determine whether colon or fecal microbiomes might be used as biomarkers of response to therapy.We searched the PubMed, Web of Science, ...
Tópico(s): Inflammatory Bowel Disease
2019 - Elsevier BV | Clinical Gastroenterology and Hepatology
Cláudia Camila Dias, Mafalda Santiago, L Correia, Francisco Portela, Paula Ministro, Paula Lago, Eunice Trindade, Alberto Freitas, Fernando Magro,
In this study, we aimed to determine the hospitalization rates of Inflammatory Bowel Disease (IBD) in a southern-european country and its associated charges over a period of 16 years.We identified all discharges with a primary diagnosis of Crohn's disease (CD) or ulcerative colitis (UC) between 2000 and 2015 in data provided by the Central Administration of Health Services (ACSS). National estimates of hospitalization rates were assessed and adjusted to gender, age, population, and hospitalizations. ...
Tópico(s): Eosinophilic Esophagitis
2019 - Elsevier BV | Digestive and Liver Disease
Stefano Urso, Rafael Sádaba, Jesús María González‐Martín, Eliú Nogales, Matteo Pettinari, María Ángeles Tena, Federico Paredes, Francisco Portela,
We explored the current evidence available on total arterial revascularization (TAR) carrying out a meta-analysis of propensity score-matched studies comparing TAR versus non-TAR strategy.PubMed, EMBASE, and Google Scholar were searched for propensity score-matched studies comparing TAR vs non-TAR. The generic inverse variance method was used to compute the combined hazard ratio (HR) of long-term mortality. The Der-Simonian and Laird method were used to compute the combined risk ratio (RR) of 30-day ...
Tópico(s): Aortic aneurysm repair treatments
2019 - Wiley | Journal of Cardiac Surgery
Produção Nacional
Revisado por pares
Massimo Sartelli, Stefano Di Bella, Lynne V. McFarland, Sahil Khanna, Luis Furuya‐Kanamori, Nadir Abuzeid, Fikri M. Abu‐Zidan, Luca Ansaloni, Goran Augustin, Miklosh Bala, Offir Ben‐Ishay, Walter L. Biffl, Stephen M. Brecher, Adrián Camacho-Ortíz, Miguel Caínzos, Shirley Chan, Jill R. Cherry‐Bukowiec, Jesse Clanton, Federico Coccolini, Maria Elena Cocuz, Raúl Coimbra, Francesco Cortese, Yunfeng Cui, Jacek Czepiel, Zaza Demetrashvili, Isidoro Di Carlo, Salomone Di Saverio, Irina Magdalena Dumitru, Christian Eckmann, Edward H. Eiland, Joseph D. Forrester, Gustavo Pereira Fraga, Jean‐Louis Frossard, Donald E. Fry, Rita Galeiras, Wagih Ghnnam, Carlos Augusto Gomes, Ewen A. Griffiths, Xavier Guirao, Mohamed H. Ahmed, Torsten Herzog, Jae Il Kim, Tariq Iqbal, Arda Işık, Kamal M.F. Itani, Francesco M. Labricciosa, Yeong Yeh Lee, Paul Juang, Aleksandar Karamarković, Peter K. Kim, Yoram Kluger, Ari Leppäniemi, Varut Lohsiriwat, Gustavo M. Machaín, Sanjay Marwah, John E. Mazuski, Gökhan Metan, Ernest E. Moore, Frederick A. Moore, Carlos A. Ordóñez, Léonardo Pagani, Nicola Petrosillo, Francisco Portela, Kemal Raşa, Miran Rems, Boris Sakakushev, Helmut Alfredo Segovia Lohse, Gabriele Sganga, Vishal G. Shelat, Patrizia Spigaglia, Pierre Tattevin, Cristian Tranà, Libor Urbánek, Jan Ulrych, Pierluigi Viale, Gian Luca Baiocchi, Fausto Catena,
In the last three decades,
Tópico(s): Microscopic Colitis
2019 - BioMed Central | World Journal of Emergency Surgery
Fernando Magro, Cláudia Camila Dias, Francisco Portela, Mário Miranda, Samuel Fernandes, Sónia Bernardo, Paula Ministro, Paula Lago, Isadora Rosa, Inês Pita, L Correia, Pedro Pereira Rodrigues,
Ulcerative colitis [UC] is a chronic inflammatory disease often accompanied by severe and distressing symptoms that, in some patients, might require a surgical intervention [colectomy]. This study aimed at determining the risk of experiencing progressive disease or requiring colectomy.This was a multicentre study: patients' data [n = 1481] were retrieved from the Portuguese database of inflammatory bowel disease patients. Bayesian networks and logistic regression were used to build risk matrices concerning ...
Tópico(s): Chronic Disease Management Strategies
2018 - Oxford University Press | Journal of Crohn s and Colitis
Cláudia Camila Dias, Pedro Pereira Rodrigues, Samuel Fernandes, Francisco Portela, Paula Ministro, Diana Martins, Paula Sousa, Paula Lago, Isadora Rosa, L Correia, Paula Moura Santos, Fernando Magro,
Introduction Crohn's disease (CD) is a chronic inflammatory bowel disease known to carry a high risk of disabling and many times requiring surgical interventions. This article describes a decision-tree based approach that defines the CD patients' risk or undergoing disabling events, surgical interventions and reoperations, based on clinical and demographic variables. Materials and methods This multicentric study involved 1547 CD patients retrospectively enrolled and divided into two cohorts: a derivation ...
Tópico(s): Autoimmune and Inflammatory Disorders
2017 - Public Library of Science | PLoS ONE
Uri Kopylov, Konstantinos Papamichael, Κωνσταντίνος Κατσάνος, Matti Waterman, Ariella Bar‐Gil Shitrit, Trine Boysen, Francisco Portela, Armando Peixoto, Andrew Szilagyi, Marco Silva, Giovanni Maconi, Ofir Har‐Noy, Peter Bossuyt, Gerassimos J. Mantzaris, Manuel Barreiro‐de Acosta, María Chaparro, Dimitrios Christodoulou, Rami Eliakim, Jean–François Rahier, Fernando Magro, David Drobne, Marc Ferrante, Elena Sonnenberg, Britta Siegmund, Vinciane Muls, Tamara Thurm, Henit Yanai, Iris Dotan, Tim Raine, Avi Levin, Eran Israeli, Fahd Ghalim, Franck Carbonnel, Séverine Vermeire, Shomron Ben‐Horin, Xavier Roblin,
Cytomegalovirus (CMV) is frequently detected in patients with ulcerative colitis (UC). The impact of CMV infection on the outcome of UC exacerbation remains unclear. The benefit of combining antiviral with anti-inflammatory treatment has not been evaluated yet. The aim of this study was to compare the outcome of CMV-positive hospitalized patients with UC treated with antiviral therapy either alone or combined with salvage anti-inflammatory therapy (infliximab [IFX] or cyclosporine A [CsA]). This was ...
Tópico(s): Mycobacterium research and diagnosis
2017 - Oxford University Press | Inflammatory Bowel Diseases
Fernando Magro, Cláudia Camila Dias, Rosa Coelho, Paula Moura Santos, Samuel Fernandes, Cidalina Caetano, Ângela Rodrigues, Francisco Portela, Ana Oliveira, Paula Ministro, Eugénia Cancela, Ana Vieira, Rita Barosa, José Cotter, Pedro Boal Carvalho, Isabelle Cremers, Daniel Trabulo, Paulo Caldeira, Artur Gião Antunes, Isadora Rosa, Joana Moleiro, Paula Peixe, Rita Herculano, Raquel Gonçalves, Bruno Gonçalves, Helena Tavares de Sousa, Luís Contente, Henrique Morna, Susana Lopes,
The definition of early therapeutic strategies to control Crohn's disease aggressiveness and prevent recurrence is key to improve clinical practice. This study explores the impact of early surgery and immunosuppression onset in the occurrence of disabling outcomes.This was a multicentric and retrospective study with 754 patients with Crohn's disease, who were stratified according to the need for an early surgery (group S) or not (group I) and further divided according to the time elapsed from the ...
Tópico(s): Autoimmune and Inflammatory Disorders
2017 - Oxford University Press | Inflammatory Bowel Diseases
Produção Nacional
Revisado por pares
Josiel Albino Lima, Caroline de Góes Sampaio, Maria Cleide da Silva Barroso, Ana Karine Portela Vasconcelos, Francisco Alberto Saraiva,
O uso dos mapas conceituais representa uma importante ferramenta para o processo de avaliacao do aprendizado do aluno, pois o professor pode observar a perspectiva do discente acerca da compreensao do assunto abordado, principalmente pela analise dos termos e das conexoes propostos nos mapas. Dessa forma, busca-se envolver o aluno de maneira ativa na sua construcao cognitiva, havendo uma avaliacao formativa. Este trabalho fundamentou-se nos conceitos da aprendizagem significativa de David Ausubel, ...
Tópico(s): Education Pedagogy and Practices
2017 - INSTITUTO FEDERAL SUL-RIO-GRANDENSE | Revista Thema
Ana Cecília da Costa Sinclair Marinho, Jeane Cruz Portela, Eulene Francisco da Silva, Nildo da Silva Dias, Francisco Souto de Sousa, A.C. Silva, Jucirema Ferreira da Silva,
In semiarid environments, it is possible to verify the fragility of soils in terms of decomposition of soil organic matter (SOM) and changes in physicochemical attributes. The objective of this study was to analyze quantitative fractions of soil organic matter (SOM) and soil's physicochemical attributes according to different agricultural uses, aiming to analyze its impact on the soil. The secondary objective was to detect which of these attributes was the most sensitive to distinguish environments. ...
Tópico(s): Soil Carbon and Nitrogen Dynamics
2016 - Southern Cross Publishing | Australian Journal of Crop Science
Paulo Freire, Ricardo Cardoso, Pedro Figueiredo, Maria Manuel Donato, Manuela Ferreira, Sofia Mendes, Ana Margarida Ferreira, M. Helena Vasconcelos, Francisco Portela, Carlos Sofia,
Tópico(s): Pregnancy and Medication Impact
2014 - Springer Science+Business Media | International Journal of Colorectal Disease