Francisco J. Reboredo, Mónica Treus, Juan C. Estévez, Luís Castedo, Ramón J. Estévez,
2-(2′-Nitrophenylethynyl)benzoic acid esters, obtained by Sonagashira coupling of o-bromobenzoates to 2-(2′-nitrophenyl)acetylenes, were converted into indeno[1,2-b]indoles by a two-step sequence, through the corresponding 2-nitrophenyl-1,3-indandiones.
Tópico(s): Synthesis and Biological Evaluation
2002 - Thieme Medical Publishers (Germany) | Synlett
Marián Fernández Villarino, Miguel González Valeiro, Belén Toja Reboredo, Francisco Carreiro da Costa,
El objetivo de este estudio fue doble: (i) describir la opinión del alumnado hacia la escuela, la Educación Física (EF) y la actividad física (AF) teniendo en cuenta el género y, (ii) caracterizar al alumnado en función de la valoración de la Educación Física y de las variables percepción de cualidades atléticas, práctica de las amistades, competencia física percibida y género. Participaron en este estudio 1273 alumnos y alumnas (48.9% de chicos, 51.1 % de chicas), de edades comprendidas entre los 10 y ...
Tópico(s): Health and Lifestyle Studies
2016 - FEADEF | Retos
Paula Carracedo-Reboredo, José Liñares-Blanco, Nereida Rodríguez-Fernández, Francisco Cedrón, Francisco J. Nóvoa, Adrián Carballal, Víctor Maojo, Alejandro Pazos, Carlos Fernández-Lozano,
Drug discovery aims at finding new compounds with specific chemical properties for the treatment of diseases. In the last years, the approach used in this search presents an important component in computer science with the skyrocketing of machine learning techniques due to its democratization. With the objectives set by the Precision Medicine initiative and the new challenges generated, it is necessary to establish robust, standard and reproducible computational methodologies to achieve the objectives ...
Tópico(s): Machine Learning in Materials Science
2021 - Elsevier BV | Computational and Structural Biotechnology Journal
Manel Antelo, Pilar Magdalena, Juan C. Reboredo, Francisco Reyes-Santías,
Objective: The purpose of this study was to measure the extent to which the advent of an economic crisis affects the magnitude of the impact of unemployment on obesity prevalence (IUOP). Methods: Using data corresponding to a boom period and a bust period of the Spanish economy, we calculated the IUOP in the Spanish population aged 16–65 years using propensity score matching, and using the difference-in-differences approach, analyzed to what extent the advent of an economic crisis affected the magnitude ...
Tópico(s): Global Health Care Issues
2020 - Multidisciplinary Digital Publishing Institute | Sustainability
Rogério Teixeira, Pedro Monteiro, Gilberto Marques, J. Pego, Margarida Lourenço, Carlos Tavares, Alda Reboredo, Sílvia Monteiro, Francisco Gonçalves, Maria João Ferreira, Mário Freitas, Graça Ribeiro, Luís A. Providência,
Inhibition of platelet aggregation appears two hours after the first dose of clopidogrel, becomes significant after the second dose, and progresses to a steady-state value of 55% by day seven. Low response to clopidogrel has been associated with increased risk of stent thrombosis and ischemic events, particularly in the context of stable heart disease treated by percutaneous coronary intervention.To stratify medium-term prognosis of an acute coronary syndrome (ACS) population by platelet aggregation. ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2012 - Elsevier BV | Revista Portuguesa de Cardiologia
Rogério Teixeira, Pedro Monteiro, Gilberto Marques, J. Pego, Margarida Lourenço, Carlos Tavares, Alda Reboredo, Sílvia Monteiro, Francisco Gonçalves, Maria João Ferreira, Mário Freitas, Graça Ribeiro, Luís A. Providência,
Clopidogrel requires oxidation dependent on the cytochrome P450 enzyme 2C19 (CYP2C19) to form its active metabolite. The importance of loss-of-function alleles (particularly CYP2C19*2, 681G>A) in poor platelet response to clopidogrel is well recognized. To investigate the prevalence and prognostic impact of the CYP2C19*2 allele in a local acute coronary syndrome (ACS) population. We performed a prospective, longitudinal study of 95 patients admitted for an ACS between March and October 2009 to a single ...
Tópico(s): Inflammatory mediators and NSAID effects
2012 - Elsevier BV | Revista Portuguesa de Cardiologia
Ramón J. Estévez, Cristian O. Salas, Francisco J. Reboredo, Juan C. Estévez, Ricardo A. Tapia,
The preliminary results of a regiospecific synthesis of (Z)-1-(2-nitrobenzylidene)isochroman-3-ones by gold(I)-catalyzed cycloisomerization of phenylethynylacetic acids under mild conditions is described. These novel lactones proved to be suitable starting materials for a new, general access to 5H-benzo[b]carbazole-6,11-diones.
Tópico(s): Plant and Fungal Species Descriptions
2009 - Thieme Medical Publishers (Germany) | Synlett
Produção Nacional
Revisado por pares
Edimar Pedrosa Gomes, Maycon Moura Reboredo, Erich Vidal Carvalho, Daniel Rodrigues Teixeira, Laís Fernanda Caldi d’Ornellas Carvalho, Gilberto Francisco Ferreira Filho, Júlio César Abreu de Oliveira, Hélady Sanders-Pinheiro, Júlio Maria Fonseca Chebli, Rogério Baumgratz de Paula, Bruno Valle Pinheiro,
Different factors can contribute to a sedentary lifestyle among hemodialysis (HD) patients, including the period they spend on dialysis. The aim of this study was to evaluate characteristics of physical activities in daily life in this population by using an accurate triaxial accelerometer and to correlate these characteristics with physiological variables. Nineteen HD patients were evaluated using the DynaPort accelerometer and compared to nineteen control individuals, regarding the time spent in ...
Tópico(s): Nutrition and Health in Aging
2015 - Hindawi Publishing Corporation | BioMed Research International
Jorge Hernández‐Urcera, Francisco Javier Murillo, Marcos Regueira, Miguel Cabanellas‐Reboredo, Miquel Planas,
Syngnathids are considered as flagship species for marine conservation. Seahorses and pipefish are highly vulnerable to anthropogenic and environmental disturbances, but most species are currently considered Data Deficient by IUCN, requiring more biological and ecological research. Although syngnathids are well known for their unusual breeding biology, some aspects on the ecology of this family have rarely received attention. The knowledge on the factors governing syngnathids distribution is limited ...
Tópico(s): Food and Agricultural Sciences
2021 - Elsevier BV | Marine Environmental Research
Belén Toja Reboredo, Francisco Carreiro da Costa, Miguel González Valeiro,
En el INEF de Galicia, al igual que en otros INEFS, desde el curso 94/95 se está impartiendo un nuevo plan de estudios, lo cual ha supuesto la aparición de nuevas asignaturas, diferente estructura, distintas exigencias para los alumnos. Con este motivo, durante el bienio 96/98, se llevó a cabo un programa de tutorización de alumnos en Practicum, que originó una investigación que culminó en una tesis doctoral (Toja, 2001). En ella, se estudió el pensamiento y experiencias de los alumnos que cursan ...
Tópico(s): E-Learning and Knowledge Management
2015 - FEADEF | Retos
Francesca Giampieri, Massimiliano Gasparrini, Tamara Y. Forbes‐Hernández, Piera Pia Manna, Jiaojiao Zhang, Patricia Reboredo‐Rodríguez, Danila Cianciosi, José L. Quiles, Cristina Torres Fernández-Píñar, Francisco J. Orantes-Bermejo, Stefano Bompadre, Sadia Afrin, Maurizio Battino,
The antioxidant capacity and the phytochemical composition of two by-products from beeswax recycling processes were recently investigated. The aim of the present work was to evaluate the efficacy of one of these by-products, MUD1, against the oxidative stress induced by 2,2'-azobis(2-amidinopropane) dihydrochloride (AAPH) in human dermal fibroblast (HDF) cells. After a preliminary viability assay, the protective effect of MUD1 was investigated through the measurement of apoptosis level, the reactive ...
Tópico(s): Botanical Research and Applications
2018 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Cristian O. Salas, Francisco J. Reboredo, Juan C. Estévez, Ricardo A. Tapia, Ramón J. Estévez,
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Tópico(s): Marine Sponges and Natural Products
2010 - Wiley | ChemInform
Ramón J. Estévez, Francisco J. Reboredo, Mónica Treus, Juan C. Estévez, Luís Castedo,
We describe herein parallel synthetic routes to isoindolo[2,1-a]indoles and 5H-indolo[2,1-a]isoquinolines from 2-(2-aminophenylethynyl)benzoicacid esters and [2-(2-aminophenyl-ethynyl)phenyl]aceticacid esters, respectively.
Tópico(s): Catalytic C–H Functionalization Methods
2003 - Thieme Medical Publishers (Germany) | Synlett
Francisco J. Reboredo, Mónica Treus, Juan C. Estévez, Luís Castedo, Ramón J. Estévez,
Abstract For Abstract see ChemInform Abstract in Full Text.
Tópico(s): Chemical synthesis and alkaloids
2002 - Wiley | ChemInform
Yunsong Liu, Jean-Daniel Paris, Grégoire Broquet, V. Roy, Tania Meixus Fernandez, Rasmus Andersen, Andrés Russu Berlanga, Emil Christensen, Yann Courtois, Sebastian Dominok, Corentin Dussenne, Travis Eckert, Andrew Finlayson, Aurora Fernández de la Fuente, Catlin Gunn, Ram A. Hashmonay, Juliano G. Hayashi, Jonathan Helmore, Soeren Honsel, F. Innocenti, M. Irjala, Torgrim Log, Cristina López, Francisco Cortés Martínez, Jonathan Martinez, Adrien Massardier, Helle Gottschalk Nygaard, Paula Agregan Reboredo, Élodie Rousset, Axel Scherello, Matthias Ulbricht, Damien Weidmann, Oliver A. Williams, Nigel Yarrow, Murès Zaréa, Robert F. Ziegler, Jean Sciare, Mihalis Vrekoussis, Philippe Bousquet,
Abstract. Methane emissions from natural gas systems are increasingly scrutinized, and accurate reporting requires quantification of site- and source-level measurement. We evaluate the performance of 10 available state-of-the-art CH4 emission quantification approaches against a blind controlled-release experiment at an inerted natural gas compressor station in 2021. The experiment consisted of 17 blind 2 h releases at a single exhaust point or multiple simultaneous ones. The controlled releases ...
Tópico(s): Spectroscopy and Laser Applications
2024 - Copernicus Publications | Atmospheric measurement techniques
Mercedes Reboredo, Haisul C. Y. Chang, Roberto Escudero Barbero, Carlos M. Rodríguez‐Ortigosa, Francisco Pérez‐Vizcaíno, Asunción Morán, Mónica García, Jesús M. Bañales, Norberto Carreño, Félix Alegre, Ignacio Herrero, Jorge Quiroga, Jesús Prìeto, Bruno Sangro,
Objective Only a limited proportion of patients needing pharmacological control of portal hypertension are hemodynamic responders to propranolol. Here we analyzed the effects of zolmitriptan on portal pressure and its potential interaction with propranolol. Methods Zolmitriptan, propranolol or both were tested in two rat models of portal hypertension: common bile duct ligation (CBDL) and CCl4-induced cirrhosis. In these animals we measured different hemodynamic parameters including portal venous ...
Tópico(s): Renal function and acid-base balance
2013 - Public Library of Science | PLoS ONE
Juan C. Reboredo, Jose Ramon Barba-Queiruga, Javier Ojea-Ferreiro, Francisco Reyes-Santías,
Abstract Background Forecasting patient arrivals to hospital emergency departments is critical to dealing with surges and to efficient planning, management and functioning of hospital emerency departments. Objective We explore whether past mean values and past observations are useful to forecast daily patient arrivals in an Emergency Department. Material and methods We examine whether an integer-valued generalized autoregressive conditional heteroscedastic (INGARCH) model can yield a better conditional ...
Tópico(s): Statistical Methods in Epidemiology
2023 - BioMed Central | Health Economics Review
María D. Navarro‐Hortal, Francisco J. Orantes-Bermejo, Cristina Sánchez‐González, Alfonso Varela‐López, Francesca Giampieri, Cristina Torres Fernández-Píñar, Josep Serra‐Bonvehí, Tamara Y. Forbes‐Hernández, Patricia Reboredo‐Rodríguez, Juan Llopis, Pilar Aranda, Maurizio Battino, José L. Quiles,
Beeswax is useful for the beekeeping sector but also for the agro-food, pharmaceutical or cosmetics sectors. Frequently, this bee product is contaminated with pesticides reducing its utility and causing the decline in its market. This study aimed to prove the effectiveness of an industrial-scale decontamination method in removing acaricides from beeswax. Chlorfenvinphos and coumaphos decrease was higher than 90%, whereas tau fluvalinate decrease was only 30%. No changes were observed in the beeswax ...
Tópico(s): Pesticide Residue Analysis and Safety
2019 - Multidisciplinary Digital Publishing Institute | Molecules
Francesca Giampieri, José L. Quiles, Francisco J. Orantes-Bermejo, Massimiliano Gasparrini, Tamara Y. Forbes‐Hernández, Cristina Sánchez‐González, Juan Llopis, Lorenzo Rivas-García, Sadia Afrin, Alfonso Varela‐López, Danila Cianciosi, Patricia Reboredo‐Rodríguez, Cristina Torres Fernández-Píñar, Rubén Calderón Iglesias, Roberto Ruíz, Silvia Aparicio Obregón, Jorge Crespo, Luís Alonso Dzul López, Jianbo Xiao, Maurizio Battino,
During the process of beeswax recycling, many industrial derivatives are obtained. These matrices may have an interesting healthy and commercial potential but to date they have not been properly studied. The aim of the present work was to evaluate the proximal and phytochemical composition, the antioxidant capacity and cytotoxic effects of two by-products from beeswax recycling process named MUD 1 and MUD 2 on liver hepatocellular carcinoma. Our results showed that MUD 1 presented the highest (P < . ...
Tópico(s): Phytochemicals and Antioxidant Activities
2017 - Elsevier BV | Food and Chemical Toxicology
Fernando Caravaca‐Fontán, Hernando Trujillo, Marina Alonso, Montserrat Díaz-Encarnación, Virginia Cabello, Gema Ariceta, Luís F. Quintana, Helena Marco, Xoana Barros, Natàlia Ramos, Nuria Rodríguez-Mendiola, Sonia Cruz, Gema Fernández‐Juárez, Eva Rodríguez, Francisco De la Cerda, Ana Pérez de José, Inmaculada López, Loreto Fernández, María Vanessa Pérez-Gómez, Ana Ávila, Luis Eduardo Bravo, Javier Lumbreras, Natalia Allende, María Dolores Sánchez de la Nieta, Teresa Olea, Marta Melgosa, Ana Huerta, Rosa Miquel, Carmen Mon, Gloria Fraga, Alberto de Lorenzo, Juliana Draibe, Fayna González, Amir Shabaka, M.L. Illescas, C Beltrán Calvo, Victoria Oviedo, Iara Da Silva, Elena Goicoechea de Jorge, Francisco Caravaca, Manuel Praga, Teresa Cavero, Ángel Sevillano, Eduardo Gutiérrez, Enrique Morales, Lucía Gómez González, Rafael Camacho Galán, Alejandra Gabaldón Domínguez, M. Garrido, Alexandra Navarro, José Antonio Cortés, Alejando Pascual Martin, Ma Luisa Pérez-Ebri, Rocío Cabrera‐Pérez, Ángel Panizo Santos, Laura Yébenes Gregorio, Maria Eugenia García Fernández, Javier Gimeno, Pablo Cannata Ortiz, Esther Roselló Sastre, Ana Sáiz, Eduardo Salido Ruiz, Rosa M. Lillo Rodríguez, Cesáreo Corbacho Cuevas, Francisco Díaz‐Crespo, Yolanda Arce, Maria Soledad Garcia-Cuerva Calvar, Carles Saus, Carmen Guerrero Márquez, Adriana García‐Herrera, Montserrat Gomà Gallego, Dolores López Álvarez, Cristina Meléndez Muñoz, Macarena Centeno, Belén Ferri Ñíguez, Juan Mosquera Reboredo, Eduardo Vázquez Martul, Sofía Pérez Gutiérrez,
Rationale & Objective A previous study that evaluated associations of kidney biopsy findings with disease progression in patients with C3 glomerulopathy (C3G) proposed a prognostic histologic index (C3G-HI) that has not yet been validated. Our objective was to validate the performance of the C3G-HI in a new patient population. Study Design Multicenter, retrospective cohort study. Setting & Participants 111 patients fulfilling diagnostic criteria of C3G between January 1995 and December 2019, from 33 nephrology ...
Tópico(s): Amyloidosis: Diagnosis, Treatment, Outcomes
2020 - Elsevier BV | American Journal of Kidney Diseases
Rogério Teixeira, Pedro Monteiro, Gilberto Marques, João Pego, Margarida Lourenço, Carlos J. Tavares, Alda Reboredo, Sílvia Monteiro, Francisco Gonçalves, Maria José Ferreira, Mário Freitas, Graça Ribeiro, Luís A. Providência,
Clopidogrel requires oxidation dependent on the cytochrome P450 enzyme 2C19 (CYP2C19) to form its active metabolite. The importance of loss-of-function alleles (particularly CYP2C19*2, 681G>A) in poor platelet response to clopidogrel is well recognized. To investigate the prevalence and prognostic impact of the CYP2C19*2 allele in a local acute coronary syndrome (ACS) population. We performed a prospective, longitudinal study of 95 patients admitted for an ACS between March and October 2009 to a single ...
Tópico(s): Inflammatory mediators and NSAID effects
2012 - Elsevier BV | Revista Portuguesa de Cardiologia (English Edition)
Rogério Teixeira, Pedro Monteiro, Gilberto Marques, J. Pego, Margarida Lourenço, Carlos Tavares, Alda Reboredo, Sílvia Monteiro, Francisco Gonçalves, Maria João Ferreira, Mário Freitas, Graça Ribeiro, Luís A. Providência,
Inhibition of platelet aggregation appears two hours after the first dose of clopidogrel, becomes significant after the second dose, and progresses to a steady-state value of 55% by day seven. Low response to clopidogrel has been associated with increased risk of stent thrombosis and ischemic events, particularly in the context of stable heart disease treated by percutaneous coronary intervention. To stratify medium-term prognosis of an acute coronary syndrome (ACS) population by platelet aggregation. ...
Tópico(s): Venous Thromboembolism Diagnosis and Management
2012 - Elsevier BV | Revista Portuguesa de Cardiologia (English Edition)
Francisco J. Reboredo, Mónica Treus, Juan C. Estévez, Luís Castedo, Ramón J. Estévez,
Abstract For Abstract see ChemInform Abstract in Full Text.
Tópico(s): Synthesis and Reactivity of Heterocycles
2003 - Wiley | ChemInform
Francisco Reyes-Santías, Juan Carlos Reboredo-Nogueira, Rosa María García-Álvarez, Sergio Cinza‐Sanjurjo, José Ramón González‐Juanatey,
Background and aim Increased mortality during the COVID-19 pandemic is not explained exclusively by COVID-19 infection and its complications. We analysed non-COVID-19 causes of mortality in a population analysis based on data from the Spanish National Institute of Statistics. Methods Using monthly mortality data in Spain (January 2010–December 2020), we analysed deaths associated with cancer, blood, endocrine, mental, nervous, cardiovascular, respiratory and digestive diseases and explored the COVID- ...
Tópico(s): Climate Change and Health Impacts
2024 - BMJ | Open Heart
Produção Nacional
Revisado por pares
Francisco Reyes-Santías, Juan C. Reboredo, Edilson Machado de Assis, Miguel Angel Rivera Castro,
This paper studies whether or not the distribution of the length of hospital stay data follows power-law probability. For hospitals differing in size and specialization, our evidence shows that length of stay is well fitted by power-law density, independently of hospital size. Moreover, failure rates differ across hospitals and are independent of hospital size and specialization.
Tópico(s): Advanced Statistical Methods and Models
2021 - Elsevier BV | Physica A Statistical Mechanics and its Applications
Produção Nacional
Revisado por pares
Miriam Garrigós Pedrón, María Dolores. Arguisuelas Martínez, Juan Carlos Julián Mauro, Flavia Costantino, Victor Monnier, Noemí Valtueña‐Gimeno, Vicente Benavent Caballer, Francisco José Martínez-Olmos, Francisco José Ferrer‐Sargues, Maycon Moura Reboredo, Vicent Esteve Simó, Eva Segura‐Ortí,
Abstract Background and Aims Pain is one of the most common symptoms among patients with End-Stage Renal Disease (ESRD), often going unrecognized or inadequately managed in people undertaking hemodialysis. Over 50% of people on hemodialysis experience pain, with 75% of them being ineffectively treated due to healthcare professionals' lack of awareness of this symptom. Managing pain in this population is a complex and challenging task for healthcare professionals. Variables related to chronic pain ...
Tópico(s): Pain Management and Opioid Use
2024 - Oxford University Press | Nephrology Dialysis Transplantation
Manuel Valladares‐Ayerbes, M. Blanco, Margarita Reboredo, María José Lorenzo-Patiño, Francisco Arnal, M. Haz Conde, Vanessa Medina Villaamil, I. Santamarina Caínzos, Luis M. Antón Aparicio, Mar Martinez,
453 Background: microRNAs (miRNAs) are small non-coding RNA with regulatory functions. miRNAs expression is deregulated in cancer. Our objective is to establish a miRNA expression profile as a prognostic and predictive signature in Colorectal Cancer (CRC). In this cohort, patients with metastatic (m) CRC have been included. The expression of miRNAs have been analyzed and correlated with clinical and pathologic parameters, including KRAS status, disease free survival (DFS), and overall survival (OS). ...
Tópico(s): Circular RNAs in diseases
2011 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Fernando Rivera, Bartomeu Massutí, Matilde Salcedo, Javier Sastre, Joaquina Martínez-Galán, Manuel Valladares‐Ayerbes, Raquel Serrano, Marisa García de Paredes, Josep Tabernero, Maica Galán, José Luis Manzano Mozo, Eduardo Díaz‐Rubio, V. Conde, Margarita Reboredo, Silvia Vázquez, L. Layos Romero, Francisco Javier Ramos Pascual, Enrique Aranda,
87 Background: Chemotherapy has improved overall survival (OS) in patients (p) with AGC and docetaxel (D), oxaliplatin (O) and capecitabine (X), have shown consistent activity in this setting. We defined "Suboptimal" p as those with PS ECOG-2 and/or weight loss 10-25% and/or age ≥70 years. This population is usually underrepresented in AGC clinical trials. Methods: We explored in 43 previously untreated "suboptimal" AGC p the "miniDOX" regimen (D: 40 mg/m2 iv, d1; O: 80 mg/m2 iv d1; C: 625 mg/m2 po bid, d1 ...
Tópico(s): Cholangiocarcinoma and Gallbladder Cancer Studies
2013 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
... Ingelmo, Fernando de la Prieta, Ana de Luis-Reboredo, Alfonso GonzÁlez-Briones Patent retrieval architecture based on ... 01.003Ricardo Sellers‐Rubio, Juan L. Nicolau‐Gonzálbez, Francisco Mas‐Ruiz The economic value of patent protection ...
Tópico(s): Sustainable Supply Chain Management
1965 - University of Chicago Press | Journal of Political Economy
M. Blanco, Mar Haz‐Conde, Teresa Rodríguez‐Rigueiro, Angélica Figueroa, Margarita Reboredo, Vanessa Medina Villaamil, María José Lorenzo-Patiño, Francisco Arnal, Luis Antón-Aparicio, Guillermo Alonso-Jáudenes Curbera, Manuel Valladares‐Ayerbes,
e21002 Background: The discovery of KRAS gene as response predictive factor to anti-EGFR antibodies supposed a revolution in the pharmacological management of metastatic colorectal cancer (mCRC) patients (pts), since only KRAS native (WT) pts are possible responders (R) and susceptible to be treated with this targeted therapy. However, the appearance of non-responders (NR) among KRAS WT pts during the administration of anti-EGFR therapy has stimulated the research in additional predictive markers. Here, ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2012 - Lippincott Williams & Wilkins | Journal of Clinical Oncology