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Alexander Street

Revisão Acesso aberto Revisado por pares

Franco Alfano, Tommaso Bigoni, Francesco Paolo Caggiano, Alberto Papi,

Respiratory syncytial virus (RSV) infection represents one of the most common infections during childhood, with significant morbidity and mortality in newborns and in the early years of life. RSV is a common infection throughout all age groups, largely undetected and underestimated in adults, with a disproportionately high impact in older individuals. RSV infection has a wide range of clinical presentations, from asymptomatic conditions to acute pneumonia and severe life-threatening respiratory distress, ...

Tópico(s): Tracheal and airway disorders

2024 - Adis, Springer Healthcare | Drugs & Aging

Artigo Acesso aberto Revisado por pares

Marco Alfano, Franco Furgiuele, Gilles Lubineau, Gláucio H. Paulino,

In this work, a cohesive zone model of fracture is employed to study debonding in plastically deforming Al/epoxy T-peel joints. In order to model the adhesion between the bonded metal strips, the Park-Paulino-Roesler (PPR) potential based cohesive model (J Mech Phys Solids, 2009;57:891-908) is employed, and interface elements are implemented in a finite element com-mercial code. A study on the influence of the cohesive properties (i.e. cohesive strength, fracture energy, shape parameter and slope indicator) ...

Tópico(s): Structural Integrity and Reliability Analysis

2011 - Elsevier BV | Procedia Engineering

Artigo Revisado por pares

Marco Alfano, Franco Furgiuele, Leonardo Pagnotta, Gláucio H. Paulino,

Abstract Adhesive bonding is a viable alternative to traditional joining systems (e.g., riveting or welding) for a wide class of components belonging to electronic, automotive, and aerospace industries. However, adhesive joints often contain flaws; therefore, the development of such technology requires reliable knowledge of the corresponding fracture properties. In the present paper, the candidate mode I fracture toughness of aluminum/epoxy joints is determined using a double cantilever beam fracture ...

Tópico(s): Numerical methods in engineering

2010 - ASM International | Journal of Testing and Evaluation

Artigo Revisado por pares

Marco Alfano, Franco Furgiuele, Alessandro Leonardi, Carmine Maletta, Gláucio H. Paulino,

Tópico(s): Fatigue and fracture mechanics

2008 - Springer Science+Business Media | International Journal of Fracture

Artigo Revisado por pares

Marco Alfano, Franco Furgiuele, Alessandro Leonardi, Carmine Maletta, Gláucio H. Paulino,

This paper deals with the application of Cohesive Zone Model (CZM) concepts to study mode I fracture in adhesive bonded joints. In particular, an intrinsic piece-wise linear cohesive surface relation is used in order to model fracture in a pre-cracked bonded Double Cantilever Beam (DCB) specimen. Finite element implementation of the CZM is accomplished by means of the user element (UEL) feature available in the FE commercial code ABAQUS. The sensitivity of the cohesive zone parameters (i.e. fracture ...

Tópico(s): Numerical methods in engineering

2007 - Trans Tech Publications | Key engineering materials

Artigo Acesso aberto Revisado por pares

Alberto Papi, Miloš Jeseňák, Franco Alfano, Diego Peroni, Federico Baraldi, Zuzana Diamant,

... Martin, SlovakiaSearch for more papers by this authorFranco Alfano, Franco Alfano Department of Translational Medicine, Respiratory Medicine, University ... Martin, SlovakiaSearch for more papers by this authorFranco Alfano, Franco Alfano Department of Translational Medicine, Respiratory Medicine, University of ...

Tópico(s): Inhalation and Respiratory Drug Delivery

2021 - Wiley | Allergy

Artigo Acesso aberto Revisado por pares

Alberto Papi, Franco Alfano, Tommaso Bigoni, Lorenzo Mancini, Amal Mawass, Federico Baraldi, Cristina Aljama, Marco Contoli, Marc Miravitlles,

N-acetylcysteine (NAC) is a mucolytic agent with antioxidant properties. Oxidative stress is a key pathogenic mechanism in chronic respiratory conditions such as COPD and chronic bronchitis (CB). In these meta-analyses we investigated the efficacy of NAC in subjects with COPD or CB, the latter being a potential pre-COPD condition (CB/pre-COPD). The meta-analyses were conducted according to PRISMA guidelines. Exacerbations were assessed using total number of exacerbations. Improvement in patients' respiratory ...

Tópico(s): Asthma and respiratory diseases

2024 - Elsevier BV | Archivos de Bronconeumología

Revisão Acesso aberto Revisado por pares

Daniela Alfano, Paola Franco, Maria Patrizia Stoppelli,

Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease urokinase (uPA), converting plasminogen into plasmin, a broad spectrum protease, active on most extracellular matrix components. Besides uPA, the uPAR binds specifically also to the matrix protein vitronectin and, therefore, is regarded also as an adhesion receptor. Complex formation of the uPAR with diverse transmembrane proteins, ...

Tópico(s): Blood Coagulation and Thrombosis Mechanisms

2022 - Frontiers Media | Frontiers in Cell and Developmental Biology

Revisão Revisado por pares

Antonio Travaglino, Antonio Raffone, Antonio Mollo, Giorgio Borrelli, Pasquale Alfano, Gian Franco Zannoni, Luigi Insabato, Fulvio Zullo,

Tópico(s): Uterine Myomas and Treatments

2020 - Springer Science+Business Media | Archives of Gynecology and Obstetrics

Revisão Acesso aberto Revisado por pares

Matteo Guarino, Edoardo Gambuti, Franco Alfano, Andrea Strada, Rachele Ciccocioppo, Lisa Lungaro, Giorgio Zoli, Umberto Volta, Roberto De Giorgio, Giacomo Caio,

Coeliac disease (CD) results from an immune-mediated reaction to gluten in genetically predisposed individuals. In rare cases CD may occur with acute features deferring the diagnosis and exposing these patients to possible life-threatening complications. Herein we present the case of a young woman with a coeliac crisis, that is, a sudden clinical onset characterised by severe electrolyte imbalance due to an unknown (previously unrecognised) CD.This is a case report and literature review revealing ...

Tópico(s): Digestive system and related health

2020 - BMJ | BMJ Open Gastroenterology

Artigo Revisado por pares

Andrea Ronchi, Marco Montella, V. Argenzio, Andrea De Lucia, Amalia De Renzo, Roberto Alfano, Renato Franco, Immacolata Cozzolino,

Peri-implant breast seroma is a late clinical presentation of reconstructive surgery or augmentation mammoplasty with breast implants. Pre-operative cytological evaluation of the peri-implant breast seroma is a common clinical approach, showing mainly an inflammatory reaction or more rarely a breast implant-associated anaplastic large cell lymphoma. Herein, we reported the role of cytology in the evaluation of peri-implant breast seroma and its critical pre-operative implications.Eight cases of ...

Tópico(s): Reconstructive Facial Surgery Techniques

2018 - Wiley | Cytopathology

Revisão Revisado por pares

Daniela Alfano, Paola Franco, Immacolata Vocca, Nadia Gambi, Viviana Pisa, Alessandro Mancini, M Caputi, Maria Vincenza Carriero, Ingram Iaccarino, Maria Patrizia Stoppelli,

The urinary-type plasminogen activator, or uPA, controls matrix degradation through the conversion of plasminogen into plasmin and is regarded as the critical trigger for plasmin generation during cell migration and invasion, under physiological and pathological conditions (such as cancer metastasis). The proteolytic activity of uPA is responsible for the activation or release of several growth factors and modulates the cell survival/apoptosis ratio through the dynamic control of cell-matrix contacts. ...

Tópico(s): Calpain Protease Function and Regulation

2005 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis

Artigo Revisado por pares

Mario Pedrazzoni, Franco Alfano, Claudia Gatti, M. Fantuzzi, G. Girasole, C. Campanini, Giuseppina Basini, M Passeri,

Tópico(s): Radiopharmaceutical Chemistry and Applications

1995 - Springer Science+Business Media | Calcified Tissue International

Artigo Revisado por pares

Mario Pedrazzoni, Franco Alfano, C. Malvi, Fabio Ostanello, M Passeri,

Though some reports suggest the existence of seasonal changes in hip fracture incidence, with a peak in winter months, other investigations have failed to confirm this finding. In this study we present data on the month-to-month variability of hip fractures in Emilia-Romagna, a region of Northern Italy with a population of approximately four million inhabitants, and in Parma, a province of Emilia-Romagna (population of approximately 400,000). Data on cervical and trochanteric fractures were obtained ...

Tópico(s): Hip disorders and treatments

1993 - Elsevier BV | Bone

Artigo Revisado por pares

P. Chiodera, Riccardo Volpi, Maria Ludovica Maffei, A. Caiazza, G. Caffarri, Cinzia Papadia, Franco Alfano, L. Capretti, Davide Pagani, V. Coiro,

The present study was undertaken in order to establish the possible involvement of GABAergic and/or opioid pathways in the mechanism underlying the arginine-vasopressin (AVP) response to physical exercise. After fasting overnight, seven subjects were tested on four mornings at least 1 week apart. Exercise was performed on a bicycle ergometer. The workload was gradually increased at 3 min intervals until exhaustion and lasted about 15 min in all subjects. Tests were carried out under administration ...

Tópico(s): Electrolyte and hormonal disorders

1993 - Elsevier BV | Regulatory Peptides

Artigo Acesso aberto Revisado por pares

Matteo Guarino, Edoardo Gambuti, Franco Alfano, Alfredo De Giorgi, Elisa Maietti, Andrea Strada, Francesco Ursini, Stefano Volpato, Giacomo Caio, Carlo Contini, Roberto De Giorgio,

Abstract Sepsis is a life-threating organ dysfunction caused by a dysregulated host response to infection. This study proposed a new tool, i.e. modified qSOFA, for the early prognostic assessment of septic patients. All cases of sepsis/septic shock consecutively observed in 2 years (January 2017–December 2018), at St. Anna University Hospital of Ferrara, Italy, were included. Each patient was evaluated with qSOFA and a modified qSOFA (MqSOFA), i.e. adding a SpO2/FiO2 ratio to qSOFA. Logistic regression ...

Tópico(s): Nosocomial Infections in ICU

2020 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases

Artigo Revisado por pares

Marco Alfano, Gilles Lubineau, Franco Furgiuele, Gláucio H. Paulino,

In this work we investigate the effect of laser irradiation on the bond toughness of aluminum/epoxy bonded joints. The evolution of substrate surface morphology and wettability, for various sets of laser process parameters (i.e. laser power, line spacing, scan speed), was investigated by means of Scanning Electron Microscopy (SEM) and contact angle measurements. A proper combination of power, line spacing and scan speed was then selected and adhesive bonded Al/epoxy T-peel joints were prepared and ...

Tópico(s): Corrosion Behavior and Inhibition

2012 - Elsevier BV | International Journal of Adhesion and Adhesives

Artigo Revisado por pares

Marco Alfano, Gilles Lubineau, Franco Furgiuele, Gláucio H. Paulino,

Tópico(s): Structural Analysis of Composite Materials

2011 - Springer Science+Business Media | International Journal of Fracture

Artigo Acesso aberto Revisado por pares

Daniela Alfano, Ingram Iaccarino, Maria Patrizia Stoppelli,

... about 8,000 surface receptors per cell. 3P. Franco, D. Alfano, and M. P. Stoppelli, unpublished data. When RPE ...

Tópico(s): Signaling Pathways in Disease

2006 - Elsevier BV | Journal of Biological Chemistry

Artigo Acesso aberto Revisado por pares

Matteo Guarino, Benedetta Perna, Alfredo De Giorgi, Edoardo Gambuti, Franco Alfano, Elisa Maria Catanese, Stefano Volpato, Andrea Strada, Giacomo Caio, Carlo Contini, Roberto De Giorgio,

Sepsis is a life-threating organ dysfunction caused by a dysregulated host response to infection. Being a time-dependent condition, the present study aims to compare a recently established score, i.e., modified quick SOFA (MqSOFA), with other existing tools commonly applied to predict in-hospital mortality.All cases of sepsis and septic shock consecutively observed at St. Anna University Hospital of Ferrara, Italy, from January 2017 to December 2018 were included in this study. Each patient was evaluated ...

Tópico(s): Clinical Reasoning and Diagnostic Skills

2022 - Springer Science+Business Media | Infection

Artigo Revisado por pares

Linda Fairtile,

... on its genesis: that of its principal creator, Franco Alfano. Following Puccini's death in November 1924, the ...

Tópico(s): Diverse Musicological Studies

2004 - Cambridge University Press | Cambridge Opera Journal

Artigo Revisado por pares

Chengzhou He,

... suggestions for the ending. Following Puccini's wish, Franco Alfano had Calaf kiss Turandot despite her reluctance, which ...

Tópico(s): Travel Writing and Literature

2012 - Penn State University Press | Comparative Literature Studies

Artigo Acesso aberto Revisado por pares

Immacolata Vocca, Paola Franco, Daniela Alfano, Giuseppina Votta, Maria Vincenza Carriero, Yeriel Estrada, M Caputi, Paolo A. Netti, Liliana Ossowski, Maria Patrizia Stoppelli,

We previously showed that, while binding to urokinase receptor (uPAR) through its growth factor domain (GFD, residues 1-49), urokinase (uPA) can engage alphavbeta5 integrin through an internal domain (CP, residues 132-158). This novel uPA/alphavbeta5 interaction promotes cytoskeletal rearrangements and directional cell migration (Franco et al., J Cell Sci 2006;119:3424-34). We now show that treatment of cells with phosphomimic uPA (uPA138E/303E, serine 138 and 303 substituted with glutamic acid) strongly ...

Tópico(s): Proteoglycans and glycosaminoglycans research

2008 - Wiley | International Journal of Cancer

Artigo Revisado por pares

Giovanni Chiodo, Marco Alfano, Stefano Pini, A. Pirondi, Franco Furgiuele, R. Groppetti,

The present work describes an experimental study about the shear strength and the mode I fracture toughness of adhesive joints with substrates pre-treated by pulsed laser ablation. An ytterbium-doped pulsed fiber laser was employed to perform laser irradiation on AA6082-T4 alloy. Morphological and chemical modifications were evaluated by means of surface profilometry, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Thick adherend shear tests were carried out in order ...

Tópico(s): Laser Material Processing Techniques

2015 - Taylor & Francis | Journal of Adhesion Science and Technology

Revisão Revisado por pares

Federica Zito Marino, Paolo A. Ascierto, Giulio Rossi, Stefania Staibano, Marco Montella, Daniela Russo, Roberto Alfano, Alessandro Morabito, Gerardo Botti, Renato Franco,

Introduction: Tumor-infiltrating lymphocytes (TILs) are frequently observed in several tumors, reflecting the dynamic process of ‘“cancer immunoediting”’. Prognostic and predictive values of TILs have been demonstrated in different cancers, proving their pivotal role in clinical outcome. In recent years, new therapies targeting immune checkpoint inhibitors, especially CTLA-4 and PD-1/PDL-1 pathways, have been introduced into clinical practice. In this context, TILs may even have a possible utility ...

Tópico(s): Immune cells in cancer

2017 - Taylor & Francis | Expert Opinion on Biological Therapy

Artigo Revisado por pares

Fabrizio Niccoli, Marco Alfano, Luigi Bruno, Franco Furgiuele, Carmine Maletta,

Tópico(s): Titanium Alloys Microstructure and Properties

2014 - Springer Science+Business Media | Journal of Materials Engineering and Performance