Deuber, Franz Xavier Anselm, Columbus, Christopher. German, Sánchez, Gabriel,
Includes bibliographical references. Book.
0000 - Gale Group | Sabin
Alexander W. E. Franz, Irma Sánchez-Vargas, Robyn Raban, William C. Black, Anthony A. James, Ken E. Olson,
In 2006, we reported a mariner (Mos1)-transformed Aedes aegypti line, Carb77, which was highly resistant to dengue-2 virus (DENV2). Carb77 mosquitoes expressed a DENV2-specific inverted-repeat (IR) RNA in midgut epithelial cells after ingesting an infectious bloodmeal. The IR-RNA formed double-stranded DENV2-derived RNA, initiating an intracellular antiviral RNA interference (RNAi) response. However, Carb77 mosquitoes stopped expressing the IR-RNA after 17 generations in culture and lost their DENV2- ...
Tópico(s): CRISPR and Genetic Engineering
2014 - Public Library of Science | PLoS neglected tropical diseases
Giles Smith, Andrew Robson, Gabriele Marcotti, David Brown, Alexandra Frean, The Rev Andrew McLuskey, Jane MacQuitty, Gary Duncan, Amanda Ursell, Alexandra Blair, Magnus Linklater, Devika Bhat, Martin Parry, David Rose, Alexandra Frean Education Editor, Philip Howard, Kathleen Lyons, David Chater, Ben Hoyle Arts Reporter, James Bone, James Ducker, Penny Wark, Andrew Copson, Dominic Wells, Richard Hobson One-Day Cricket Correspondent, Jonathan Strode, Angus MacLeod Scottish Political Editor, Sam Marlowe, Wendy Ide, James Hider, Geoff Brown, Joe Joseph, Andrew Norfolk, Robin Pagnamenta, Giles Coren, Ben Webster Transport Correspondent, Donald Hutera, Siobhan Kennedy, Jack Malvern, Dominic Walsh, Steve Bird, Shirley English, Lòúisa Barnett, Rory Watson, Gary Jacob, Ken Russell, Richard Ford Home Correspondent, Jenny MacArthur, Anatole Kaletsky, Rhys Blakely, Charles Bremner, Richard Johnson, Adam Sherwin Media Correspondent, Matt Dickinson Chief Football Correspondent, Greg Hurst, Sue Mallia, Hugo Rifkind, Bruce Kent, Derwent May, Robin Barber, Jenny Kleeman, Barry Baines, Gary Duncan Economics Editor, Oliver Kay, Carola Long, Jane Wheatley, Mark Henderson Science Editor, John Westerby, James Harding Business Editor, Ron Goldstein, Rick Broadbent, Tom Baldwin, James Rossiter, Pete Paphides, Christopher Martin-Jenkins, Rob Wright, Neil Harman Tennis Correspondent, Brian P. Moss, Raymond Keene, Adam Sage, Lewis Smith, Matthew Pryor, Mike Caplan, Matt Hughes, Rebecca O'Connor, Sean O'Neill, Kaveh Solhekol, Andrew Drummond, Nigel Hawkes, Jeremy Page, Burhan Wazir, Fran Yeoman, Hattie Garlick, Patrick Hosking, Helen Nugent, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Marcus Leroux, Damian Whitworth, Roger Boyes, Francesca Steele, Neil Allies, David Hands Rugby Correspondent, Tom Dart, Tony Cascarino, Kevin Maher, Neil Jones, Paul Simons, Michael Herman, Peter Maxwell Davies, Rev Alan Cliff, Dearbáil Jordan, James Doran, Philip Webster Political Editor, Steve Hawkes, Ian Johns, Matthew Parris, Graham Searjeant Financial Editor, Neil Fisher, Alan Lee, Melanie McDonagh, Philip Webster, David Sanderson, Graham Searjeant, Rev Vincent Nichols, Catherine Philp, Lewis Smith Environment Reporter, Michael Horsnell, Carl Mortished International Business Editor, Patrick Foster, Nigel Hawkes Health Editor, John Baldwin, Sarah Butler, Angus Batey, Sam Coates Political Correspondent, Dr Thomas Stuttaford, Cliff Hassall, Stephen Dalton, Tim Luckhurst, Nicola Woolcock, Leo Lewis, Bill Edgar, James Christopher, Michael Evans, Alan Lee Racing Correspondent, Alexandra Blair Education Correspondent, Olav Bjortomt, Mark Schuck, Robbie Millen, David Robertson, Richard Ford, Bryce Elder, Joe Bolger, Lisa Verrico,
... Fulham's fate likely to decide future of Sanchez Wilkinson Sword Desperate ... Franz Beckenbauer, the Bayern Munich president, has … If Chelsea ...
2007 - Gale Group | TDA
Alexander W. E. Franz, Irma Sánchez-Vargas, Joseph Piper, Mitchell R. Smith, Cynthia Khoo, Anthony A. James, Ken E. Olson,
Abstract Transgenic Aedes aegypti were engineered to express a virus‐derived, inverted repeat (IR) RNA in the mosquito midgut to trigger RNA interference (RNAi) and generate resistance to dengue virus type 2 (DENV2) in the vector. Here we characterize genotypic and phenotypic stabilities of one line, Carb77, between generations G 9 and G 17 . The anti‐DENV2 transgene was integrated at a single site within a noncoding region of the mosquito genome. The virus resistance phenotype was strong until G 13 ...
Tópico(s): Insect Resistance and Genetics
2009 - Wiley | Insect Molecular Biology
Andrew Robson, Martin Berthoud, Jon Ashworth, Max White, Robert Cole, Magnus Linklater Commentary, Andrew Pierce, Neelam Verjee, Zahid Hussain, Adam Sherwin Media Reporter, Greg Hurst Political Correspondent, Frances Gibb Legal Editor, Peter Lansley, Robert Thicknesse, Mark Souster, Ian Blackshaw, David Rhys Jones, Stephen Farrow, Tosin Sulalman, Michael Evans Defence Editor, Gabriel Coxhead, Philip Howard, Hilary Finch, Christine Seib, David Chater, Jeremy Kingston, Rosalind Renshaw, Carl Mortished, David Greenwood, Sam Marlowe, Kamil Tchorek and Michael Horsnell, Kevin Eason, David Winsor, Joe Joseph, David Sharrock, Antonia Senior, Pat Gibson, David McVay, S. Sussman, Alan Titchmarsh, Louis Dunn, Stewart Tendler Crime Correspondent, Jim Kelsey, Tom Bawden, Dominic Walsh, James Doran Wall Street Correspondent, John Radford, Mr Paul Bowen, Joe Morgan, Jill Dupleix, Tim Reid, Daniel Finkelstein, Angela Jameson Industrial Correspondent, Toby Moore, Dalya Alberge Arts Correspondent, Mark Henderson and Nigel Hawkes, Robin Young, Alan Hamilton, Phil Gordon, Miranda Ingram, R. Reid, Virginia Crompton, Barney Smith, Charles Bremner, Sara Lawrence, Ian MacKinnon, Ron Lewis, Matt Dickinson Chief Football Correspondent, Greg Hurst, Helen Scott-Cook, Laurence Oates, Joan Wyndham, Caroline Merrell Banking Correspondent, John L. F. Brownridge, Phoebe Winch, M. W. T. Bullock, Russell Kempson, Jerome Burne, Oliver Kay, Jane Gordon, Lisa Armstrong, Richard Lancaster, Neil Harman, Julian Evans, Sonia Keates, Michael Evans Defence Editor and Michael Horsnell, Tom Baldwin, Patrick Hosking Investment Editor, Holly Finn, Stephen Farrell and Ali Hamdani, Ann Treneman, Angus Macleod, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Karen Homer, Karen Tiernan, Tom Worsley and Siân Morgan, Francis Bennion, Stephen Farrell and Richard Owen, Neil Harman Tennis Correspondent, Martin Samuel, Raymond Keene, Joanna Walsh, Michael Beal, Helena De Bertadano, Jeremy Page, Margaret E. Gibbons, James Bovington, Hannah Westfield, Oliver August, Peter Dixon, Laura Cowan, David Hands Rugby Correspondent, Adam Fresco, Anne Ashworth, Peter Prior, Philip Webster Political Editor, Tosin Sulaiman, Jane Pugh, Ian Johns, George Caulkin, Mike Kemp, Russell Jenkins, Neil Fisher, Ingrid Mansell, Bronwen Maddox Foreign Editor's, Katherine Brunt, Peter Riddell, Richard Beeston Diplomatic Editor, David Charter Chief Political Correspondent, Philip Webster, Anthony Browne and Suna Erdem, Jack Malvern Arts Reporter, Smaller Capitalisation Shares, Simon Jenkins, Lewis Stuart, Gary Duncan Economics Correspondent, Martin Waller, Carl Mortished International Business Editor, Angus Batey, Lydia Hislop, Dr Thomas Stuttaford, Stephen Dalton, Nicola Woolcock, Richard Morrison, Bill Edgar, Alice Miles, Randy Cohen, Clare Dight, Alan Lee Racing Correspondent, Moira Brodie, Jenny Davey, Peter Klinger, Sam Lister Health Correspondent, Patience Wheatcroft, Joe Bolger, Christopher Irvine,
... already have an alternative to the floundering Eriksson Sanchez searches for elusive victory cheer Greeks soon made ...
2004 - Gale Group | TDA
Alexander W. E. Franz, Irma Sánchez-Vargas, Zach N. Adelman, Carol D. Blair, Barry J. Beaty, Anthony A. James, Ken E. Olson,
Mosquitoes ( Aedes aegypti ) were genetically modified to exhibit impaired vector competence for dengue type 2 viruses (DENV-2). We exploited the natural antiviral RNA interference (RNAi) pathway in the mosquito midgut by constructing an effector gene that expresses an inverted-repeat (IR) RNA derived from the premembrane protein coding region of the DENV-2 RNA genome. The A. aegypti carboxypeptidase A promoter was used to express the IR RNA in midgut epithelial cells after ingestion of a bloodmeal. The ...
Tópico(s): Insect Resistance and Genetics
2006 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Andrew Robson, Dr Thomas Stuttaford Medical Briefing, Rowan Dunning, Frank Lay, Jon Ashworth, Daniel McGrory and Rory Watson, David Adams, Robert Cole, Fred Redwood, Andrew Pierce, DJM, Chris Ward, Zahid Hussain, Adam Sherwin Media Reporter, Sarah Potter, Iain Edwards, Simon Barnes, Maureen Jolley, Magnus Linklater, Duncan Grey, Stuart MacWhirter, Mark Souster, Elien Connolly, Paul Godwin, Michael Evans Defence Editor, Philip Howard, Stephen Edwards, Jennal Cox Fitness Editor, Sir David Ramsbotham, Christine Seib, David Chater, Raymond Snoddy and Tom Baldwin, James Bone, P. A. S. Taylor, Nic Hopkins, Clive Davis, Nicky Samengo-Turner, Elizabeth Judge, Gabrielle Starkey, Rosalind Renshaw, Sam Marlowe, Ian Cabain and Stewart Tendler, Patrick Barkham, Neville Conrad, Joe Joseph, Andrew Norfolk, Peter Brown, Antonia Senior, Richard Colborne, Rowing Coach, David McVay, John Farrington (Research Fellow), Mike Smith-Rawnsley, Patience Wheatcroft Business Editor's Commentary, Alan Lee the Course Inspector, David Bebbington, Dominic Walsh, Ruth Gledhill, Tom Bawden, James Doran Wall Street Correspondent, Richard Wilson (Business Policy Executive), Avant-Garde Challenge, Jill Dupleix, Tim Reid, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Les Clifford, Libby Purves, Phoebe Greenwood, Oliver Wright Health Correspondent, Randhir Singh Bains, James Williams, Leeds, Phil Gordon, Valerie Elliott Consumer Editor, Roland Watson, Richard Beeston Diplomatic Editor and James Kilner, Iain MacKintosh (Director), Charles Bremner, Liz Nicholl, Head of Performance, Michele Pavlou-Proestou, Mark Browne, David Drew, Ludgvan, Cornwall, David Alexander, Stefanie Marsh, Matt Dickinson Chief Football Correspondent, HMS Victory, Patience Wheatcroft Business Editor, David Charter and Tom Baldwin, Russell Kempson, Peter Paphides, Vanora Bennett, Tony Halpin Education Editor, Oliver Kay, Jane Gordon, Lisa Armstrong, Pamela Smith, Fleet, Hampshire, Michael Theodoulou, Rick Broadbent, Tom Baldwin, Jake and Dinos Chapman, James North, Mark Henderson Science Correspondent, Sam Coates, Rick Sareen, Brian North Lee, Dave Hallsworth, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Geoffrey Dean, Karen Homer, Susan Pape, Martin Samuel, Abigail Rayner and James Doran, Raymond Keene, Carol Jeynes, Richard Bailey, Lewis Smith, John Russell Taylor, Peter Riddell Political Briefing, Roy Setter, Christine Buckley Industrial Editor, B. Gibb-Gray, Emsworth, Hampshire, Rosemary Bennett Deputy Political Editor, Xan Rice, Caroline Merrell, Peter Dodd, Sigmar Polke, Chris Campling, Richard Owen, Damian Whitworth, Alex Hawkes, Emily Davies, Oliver August, Nick Hasell, Sally Morris, Carl Mortished European Briefing, Tom Dart, Paul Simons, Amir Taberi, Adam Fresco, John Allison, John Goodbody, Mary Ann Sieghart, Jonathan Clayton, Philip Webster Political Editor, david Tanner, International Manager, Monica E. Seeley, Dominic Waish, Chris McGrath, George Caulkin, Peter Riddell, Tony Dawe, Stephen Farrell and Yonlt Farago, David Charter Chief Political Correspondent, David Sinclair, Simon Jenkins, Anne Ashworth Personal Finance Editor, Gary Duncan Economics Correspondent, Martin Waller, Brian G. Trower-Greenwood, Laura Peek, Sarah Butler, Ashling O'Connor, Benedict Nightingale, Dr Thomas Stuttaford, Stephen Dalton, Hugh Thompson, Lee Oliver, Tunbridge Wells, Kent, Martin Samuel Sports Writer, Frances Gibb, Bill Edgar, Simon Crompton, Ann Treneman Conference Sketch, Michael Evans, Randy Cohen, Allan Hall, Stanley Blenkinsop, Huw Beynon, Olav Bjortomt, Jenny Davey, David N. Talbot (Principal), Andrew Richardson, Richard Philips,
... Nationwide League First Division Defeat spells end for Sanchez at Wycombe Pools Forecast Lewis remains at helm ... Brothers Retrospective Jake and Dinos Chapman Saatchi Gallery Franz West Whitechapel Art Gallery Again, Male Genitals Sprout ...
2003 - Gale Group | TDA
DON T. MARTIN, James A. Banks,
... as Carter G. Woodson, Allison Davis, George I. Sanchez, Franz Boas, Mourning Dove, Ella Deloria, and Robert E. ...
Tópico(s): Education Systems and Policy
1997 - Cambridge University Press | History of Education Quarterly
Waldemar Januszczak, Barry Worrall, Terry Baldwin, Martin Gilbert, Michael Laudrup, Jonathan Miller, Sal Romeguera, Alfredo di Stéfano, Gareth Walsh, Ferdinand Mount, Sam Gilpin, Mark Goodall, Sarah Milstein, Hristo Stoichkov, Davor Suker, Peter Oborne, Nigel Lawson, A C, Joseph Dunn, Martin James, Sean Penn, Anthony Sattin, John Swannell, Arsène Wenger, Rosie Millard, India Hicks, Gill Fraser, David Hewson, Hugh Canning, S L, Sarah Dempster, Kevin Jackson, Rupert Wright, Jonathan Margolis, Lord March, Debra Lewis, Alicia Wyllie, Dave Hannigan, Neil Beckingham, Trevor Hamley, Hugh Faulkner, Brian Hughes, Lawrence Booth, Stephanie Manuel, Jim Irvin, Philip Stott, Uzi Mahnaimi, Milla Jovovich, Chris Harris, Cara Grayling, John Harrop, Fiona Terry, D Rimmer, Gareth Southgate, Bryan Appleyard, John Elliott, Burlington Bertie, Maurice Chittenden, Michel Platini, Richard Brooks Arts Editor, Dan Box, Helen Mound, Matthew Campbell, Jacqui Goddard, Howard Jacobson, Simon Spilsbury, Peter Schmeichel, Jennifer Lopez, James Knight, Graham Norwood, Zdenek Nehoda, Stewart Mitchell, Neil Hanson, Susannah Price, Sarah Baxter, Ed Hughes, Jason Dawe, Lucy Moore, Charlie Chaplin, Jonathan Northcroft, Lucas Hollweg, N J, Franz Beckenbauer, Andrew Longmore, Gerard Houllier, Dennis Quaid, David Lloyd George, Steven Poole, Nikos Anastopoulos, E P, Andrew Sullivan, Clive Davis, Clive Christie, Matt Rudd, William Gladstone, Sylvie Brown, Patrick Campbell, Tom Cruise, Michael Harrison, David Bond, Victoria Segal, Edward Porter, Dave Pollard, Andrew Porter Deputy Political Editor, Peter Parker, Christopher Silvester, Paul Donovan, Peter Hounam, Louis Saha, Steve Boyd, John Follain, Richard Brooks, Shelly Von Strunckel, Johan Cruyff, Stuart Andrews, David Leppard, Val Kilmer, Lev Yashin, Gareth Huw Davies, Barry Flatman, Natalie Graham, Jessica Brinton, Sally Brook, David Walsh, Sylvester Stallone, Michael Platini, Stephen Armstrong, Bethan Cole, Michael Sheridan Far East Correspondent, N R, Sally Cox, Ray Hutton, Mel Webb, M E, David Lunn, Martin O'neill, Andrew Stephen, A A Gill, Peter Cornick, Michael Spencer, John Motson, T L, Roger Dobson, John Aizlewood, Ben Dowell, Jeremy Lazell, John Cornwell, Lord Joel Joffe, Jonathan Futrell, Hugh Pearman, John Rhall, Audrey Hepburn, John Dugdale, Barbara Hall, Rob Hughes, John Peter, Adam Hathaway, D Finnigan, Jon Blankfield, Susan d'Arcy, Jane Mulkerrins, Carl Braganza, Ivo Tennant, David Gower, Matt Wolf, Tara Bernerd, David Smith, Tim Richards, Nick Pitt, Andrew Williams, Kate Reardon, C D, D C, John O'Brien, Tom Walker, Leslie Geddes Brown, Adrian Furnham, Christopher Hart, Isabella Dusi, Anthony Phillips, Sir Brian Barder, Virginia Nicholson, Michael Portillo, Patricia Nicol, Richard Fletcher, Jonathan Birt, Derren Hayes, Sarah-Kate Templeton, Marlon Brando, Paul Kimmage, Chris Woodhead, Scott Nicholls, Alex Clark, Mark Edwards, Rachel Bridge, Susan Clark, Kira Cochrane, Jonathan Carr-Brown Health Correspondent, Sean Newsom, Raymond Keene, Allyson Webb, Stephen Jones, Stephen Bleach, Louise Armitstead, Nick Cain, Frankel, Tim Moorey, Hugh McManners, Jeremy Lewis, Michael Keaton, Trevor Lewis, Collin McDowell's, Bobby Moore, Victoria O'brien, Roland White, Richard Rae, Jon Ungoed-Thomas, Heinz Hermann, Dipesh Gadher, John Waples, Jeremy Hart, Ros Dodd, Stephen Pettitt, Sean Connery, Justin Sparks, Mark Hodson, Andrew Frankel, Joe Lovejoy, Rael Dornfest, David Smith Economics Editor, Penny Perrick, Robert Mitchum, Simon Howard, Dominic Rushe, Yael Lotan, Philip Green, Helena Frith Powell, Esther Rantzen, Helen Davies, Gideon Garter, David Wilson, Christopher Somerville, Adam Luck, Ted Pridham, Frank Whitford, Kathryn Cooper, P D, Melanie Rickey, Matt Goss, Andrew Porter, Tony Allen-Mills, Simon Wilde, Sylvie, Robert Winnett, Irwin Stelzer, Robert Hewison, Peter Wilson, Tom McEnaney, David Dougill, Gunnar Nordahl, Paul Spare, Alan Wilson, Roslyn Pine, Jeremy Clarkson, David Cairns, Robert Ryan, Percy Gibson, Greg Struthers, Lydia Slater, Damon Dash, Paul Ham, Roger Eglin, Simon Mills, Professor Zvi Naor Fabien Borocin, Paul Driver, Derek Clements, Ian Hawkey, Renee Zellweger, Paul Durman, David Stephenson, Colin Goodwin, Jane Nottage, Phil Baker, Ruth Lea, Cosmo Landesman, Helen Hawkins, Dominic O'Connell, Vitalijs Astafjevs, Adrienne Connors, Jose Mourinho, Miranda Seymour, John Stern, Shane Watson, Judith O'Reilly, Dr Charles Njoku, Jonathan Leake, Clare Francis, John Harlow, Will Iredale, Robert de Niro, Sally Kinnes, Naomi Caine, Minette Marrin, Olivia de Havilland, Andrew Davidson, Amir Taheri, Stephen Gray, Paolo Maldini, Emma Sanchez, David Robertson, Matthew Goodman, India Knight, Nina Goswami, Adrian Somerfield,
Contents US mourns the death of Reagan Contents Virgin atlantic Firms to be hit by junk food levy for sports centres Heroims revisited in Normandy Fields ...
2004 - Gale Group | Sunday Times HA GDA
Produção Nacional
Revisado por pares
Marlon Heitor Kunst Valentini, Gabriel Borges dos Santos, Victória Huch Duarte, Henrique Sanchez Franz, Hugo Alexandre Soares Guedes, Rúbia Flores Romani, Bruno Müller Vieira,
Tópico(s): Water Quality Monitoring Technologies
2021 - Springer Science+Business Media | Water Air & Soil Pollution
Salvatore Incontro, Francisco Ciruela, Edward B. Ziff, Franz Hofmann, José Sánchez‐Prieto, Magdalena Torres,
Trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) is regulated by specific interactions with other proteins and by post-translational mechanisms, such as phosphorylation. We have found that the type II cGMP-dependent protein kinase (cGKII) phosphorylates GluA1 (formerly GluR1) at S845, augmenting the surface expression of AMPARs at both synaptic and extrasynaptic sites. Activation of cGKII by 8-Br-cGMP enhances the surface expression of GluA1, whereas its inhibition ...
Tópico(s): Ion channel regulation and function
2013 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
María Teresa Gómez‐Pugnaire, Gerhard Franz, Vicente López Sánchez‐Vizcaíno,
Tópico(s): Geological and Geochemical Analysis
1994 - Springer Science+Business Media | Contributions to Mineralogy and Petrology
Paulina Jakubiak, Björn Wagner, Hans Peter Grimm, Jeannine Petrig-Schaffland, Franz Schuler, Rubén Alvarez‐Sánchez,
Drug absorption is a complex process involving dissolution and precipitation, along with other kinetic processes. The purpose of this work was to (1) establish an in vitro methodology to study dissolution and precipitation in early stages of drug development where low compound consumption and high throughput are necessary, (2) develop a mathematical model for a mechanistic explanation of generated in vitro dissolution and precipitation data, and (3) extrapolate in vitro data to in vivo situations using ...
Tópico(s): Analytical Methods in Pharmaceuticals
2015 - American Chemical Society | Molecular Pharmaceutics
Trinidad León‐Quinto, Miguel A. Simón, Ángel Sánchez, Franz Martı́n, Bernat Soria,
Cryobanking skin samples permit preserving a maximum of genetic representation from the population biodiversity. This is a relevant aspect for threatened species, potentially menaced by an epizooty and from which it is difficult to obtain gametes. As a first step for properly cryobanking skin samples of a given species, the optimal conditions of culture and freezing have to be studied by covering a broad range of possibilities. This paper presents, for the first time, a systematic study of such ...
Tópico(s): Animal Genetics and Reproduction
2011 - Elsevier BV | Cryobiology
L. Morales-Molina, Niurka R. Quintero, Ángel Sánchez, Franz G. Mertens,
We study in detail the ratchetlike dynamics of topological solitons in homogeneous nonlinear Klein-Gordon systems driven by a biharmonic force. By using a collective coordinate approach with two degrees of freedom, namely the center of the soliton, X(t), and its width, l(t), we show, first, that energy is inhomogeneously pumped into the system, generating as result a directed motion; and, second, that the breaking of the time shift symmetry gives rise to a resonance mechanism that takes place whenever ...
Tópico(s): Combustion and flame dynamics
2006 - American Institute of Physics | Chaos An Interdisciplinary Journal of Nonlinear Science
L. Morales-Molina, Franz G. Mertens, Ángel Sánchez,
We investigate the ratchet dynamics of nonlinear Klein-Gordon kinks in a periodic, asymmetric lattice of pointlike inhomogeneities. We explain the underlying rectification mechanism within a collective coordinate framework, which shows that such a system behaves as a rocking ratchet for point particles. Careful attention is given to the kink width dynamics and its role in the transport. We also analyze the robustness of our kink rocking ratchet in the presence of noise. We show that the noise activates ...
Tópico(s): Chaos control and synchronization
2005 - American Physical Society | Physical Review E
L. Morales-Molina, Niurka R. Quintero, Franz G. Mertens, Ángel Sánchez,
We study directed energy transport in homogeneous nonlinear extended systems in the presence of homogeneous ac forces and dissipation. We show that the mechanism responsible for unidirectional motion of topological excitations is the coupling of their internal and translation degrees of freedom. Our results lead to a selection rule for the existence of such motion based on resonances that explains earlier symmetry analysis of this phenomenon. The direction of motion is found to depend both on the ...
Tópico(s): Advanced Thermodynamics and Statistical Mechanics
2003 - American Physical Society | Physical Review Letters
Niurka R. Quintero, Ángel Sánchez, Franz G. Mertens,
We study the dynamics of straight phi(4) kinks perturbed by an ac force, both with and without damping. We address this issue by using a collective coordinate theory, which allows us to reduce the problem to the dynamics of the kink center and width. We carry out a careful analysis of the corresponding ordinary differential equations, of Mathieu type in the undamped case, finding and characterizing the resonant frequencies and the regions of existence of resonant solutions. We verify the accuracy ...
Tópico(s): Advanced Fiber Optic Sensors
2000 - American Physical Society | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
Niurka R. Quintero, Ángel Sánchez, Franz G. Mertens,
We investigate the nonparametric, pure ac driven dynamics of nonlinear Klein-Gordon solitary waves having an internal mode of frequency Omega(i). We show that the strongest resonance arises when the driving frequency delta = Omega(i)/2, whereas when delta = Omega(i) the resonance is weaker, disappearing for nonzero damping. At resonance, the dynamics of the kink center of mass becomes chaotic. As we identify the resonance mechanism as an indirect coupling to the internal mode due to its symmetry, we ...
Tópico(s): Nonlinear Dynamics and Pattern Formation
2000 - American Physical Society | Physical Review Letters
Niurka R. Quintero, Ángel Sánchez, Franz G. Mertens,
We study whether or not sine-Gordon kinks exhibit internal modes or ``quasimodes.'' By considering the response of the kinks to ac forces and initial distortions, we show that neither intrinsic internal modes nor ``quasimodes'' exist in contrast to previous reports. However, we do identify a different kind of internal mode bifurcating from the bottom edge of the phonon band which arises from the discretization of the system in the numerical simulations, thus confirming recent predictions.
Tópico(s): Advanced Fiber Laser Technologies
2000 - American Physical Society | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
Sonia Bolea, José A. G. Pertusa, Franz Martı́n, Juan V. Sánchez-Andrés, Bernat Soria,
Tópico(s): Diabetes Management and Research
1997 - Springer Science+Business Media | Pflügers Archiv - European Journal of Physiology
Albert Schinzel, Isabel Lorda‐Sánchez, Franz Binkert, N P Carter, Charlotte E. Bebb, M.A. Ferguson‐Smith, Urs Eiholzer, M. Zachmann, Wendy P. Robinson,
Prometaphase chromosomes from a 16 year old boy with hypogonadotrophic hypogonadism and anosmia (Kallmann syndrome) showed a tiny chromosome fragment attached to the long arm of one chromosome 1 without a visible reciprocal translocation chromosome. Chromosome painting with libraries from chromosomes 1 and X excluded a t(X;1) translocation, but failed to detect a second translocation chromosome. Through reverse chromosome painting, an unbalanced der(1), t(1;10) (q44;q26) translocation could be detected. ...
Tópico(s): DNA and Nucleic Acid Chemistry
1995 - BMJ | Journal of Medical Genetics
Franz Martı́n, Juan V. Sánchez-Andrés, Bernat Soria,
The effect of alpha-ketoisocaproate (KIC), the first catabolic metabolite of the amino acid leucine, on [Ca2+]i, insulin release, and membrane potential was measured in mouse pancreatic islets of Langerhans. Stimulatory concentrations of KIC (2.5-10 mmol/l) caused slow oscillations of [Ca2+]i and cyclic variations of the membrane potential. Slow [Ca2+]i oscillations depended on extracellular calcium. Simultaneous measurements of [Ca2+]i and insulin release resolved pulsatile insulin secretion that paralleled ...
Tópico(s): Diabetes Management and Research
1995 - American Diabetes Association | Diabetes
Franz Martı́n, Juan V. Sánchez-Andrés, Bernat Soria,
Tópico(s): Metabolism, Diabetes, and Cancer
1995 - American Diabetes Association | Diabetes
Isabel Lorda‐Sánchez, Franz Binkert, K Hinkel, Hans Moser, W Rosenkranz, Marco Maechler, Albert Schinzel,
The parental origin of the additional sex chromosomes in 8 cases with high-order sex chromosome polysomies was determined using DNA polymorphisms. The additional sex chromosomes were paternally derived in 3 48,XXYY cases, and maternal in origin in 1 48,XXXY case and 4 49,XXXXY cases. Thus, all extra chromosomes, within a particular patient, were always derived from only one parent. Their most likely origin was successive nondisjunction at the first and second meiotic division in one germ cell. The ...
Tópico(s): Reproductive Health and Technologies
1992 - Karger Publishers | Human Heredity
Isabel Lorda‐Sánchez, Franz Binkert, Marco Maechler, Albert Schinzel,
Abstract The parental origin of the single X in 45 cases (40 liveborns and 5 fetuses) with a 45, X karyo‐type was studied using polymorphic DNA probes. The single X was paternal in origin (X p ) in 10 cases (22.2%) and maternal (X m ) in 35 cases (77.8%). Y chromosome material was detected in 1 out of the 35 cases with a 45, X m constitution. Analysis of parental ages and clinical data of the patients with respect to the origin of the single X revealed no significant differences between the origins.
Tópico(s): Prenatal Screening and Diagnostics
1992 - Wiley | American Journal of Medical Genetics
Isabel Lorda‐Sánchez, Franz Binkert, Marco Maechler, WendyP. Robinson, AlbertA. Schinzel,
Tópico(s): LGBTQ Health, Identity, and Policy
1992 - Springer Science+Business Media | Human Genetics
Niurka R. Quintero, Ángel Sánchez, Franz G. Mertens,
We study the sine-Gordon kink diffusion at finite temperature in the overdamped limit. By means of a general perturbative approach, we calculate the first- and second-order (in temperature) contributions to the diffusion coefficient. We compare our analytical predictions with numerical simulations. The good agreement allows us to conclude that, up to temperatures where kink-antikink nucleation processes cannot be neglected, a diffusion constant linear and quadratic in temperature gives a very accurate ...
Tópico(s): Nonlinear Dynamics and Pattern Formation
1999 - American Physical Society | Physical review. E, Statistical physics, plasmas, fluids, and related interdisciplinary topics
Sara Belli, Frauke Assmus, Bjoern Wagner, Michael Honer, Holger Fischer, Franz Schuler, Rubén Alvarez‐Sánchez,
The unbound drug concentration-effect relationship in brain is a key aspect in CNS drug discovery and development. In this work, we describe an in vitro high-throughput distribution assay between an aqueous buffer and a microemulsion of porcine brain polar lipids (BPL). The derived distribution coefficient LogDBPL was applied to the prediction of unbound drug concentrations in brain (Cu,b) and nonspecific binding to brain tissue. The in vivo relevance of the new assay was assessed for a large set ...
Tópico(s): Antibiotics Pharmacokinetics and Efficacy
2015 - American Chemical Society | Molecular Pharmaceutics
Matthias Meister, Franz G. Mertens, Ángel Sánchez,
We investigate the diffusive motion of a solitary wave on a classical, isotropic, ferromagnetic Heisenberg spin chain with nearest-neighbour exchange interaction. The spins are coupled magnetically to Gaussian white noise and are subject to Gilbert damping. The noise induces a collective, stochastic time evolution of the solitary wave. Within a continuum version of the model we employ implicit collective variables to describe this stochastic behaviour. Thermally excited magnons are disregarded. ...
Tópico(s): Complex Systems and Time Series Analysis
2001 - Springer Science+Business Media | The European Physical Journal B