Nancy Aguilar-Olivos, Daniel Carrillo-Córdova, Jesús Oria‐Hernández, Vicente Sánchez-Valle, Guadalupe Ponciano‐Rodríguez, Manuel Ramírez-Jaramillo, Fredy Chablé-Montero, Norberto C. Chávez‐Tapia, Misael Uribe, Nahúm Méndez‐Sánchez,
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease. Patients with non-alcoholic steatohepatitis (NASH) have increased plasmatic and hepatic concentrations of bile acids (BA), suggesting that they can be associated with the progression of the disease. Hepatic nuclear receptors are known to modulate genes controlling BA metabolism; thus, in this work we aimed to compare the expression of liver nuclear receptors -farnesoid X (FXR), small heterodimer partner (SHP) ...
Tópico(s): Liver Diseases and Immunity
2015 - Elsevier BV | Annals of Hepatology
Jorge Albores‐Saavedra, Juan Carlos Córdova-Ramón, Fredy Chablé-Montero, Rita Dorantes-Heredia, Donald E. Henson,
Tópico(s): Pancreatic and Hepatic Oncology Research
2015 - Elsevier BV | Annals of Diagnostic Pathology
Jorge Albores‐Saavedra, Fredy Chablé-Montero, Oscar X. Hernández-Rodríguez, Daniel Montante-Montes de, Arturo Angeles‐Angeles,
We report 2 examples of inverted urothelial papillomas with a focal papillary pattern. Both patients, a 43-year-old man and a 13-year-old adolescent boy, presented with hematuria. In addition to the characteristic trabecular endophytic growth pattern and bland cytologic features, the tumors showed focal papillary architecture in the endophytic component. Because of this feature, both tumors were misinterpreted as papillary urothelial carcinoma with inverted pattern. However, the papillary fronds ...
Tópico(s): Urinary and Genital Oncology Studies
2009 - Elsevier BV | Annals of Diagnostic Pathology
Jorge Albores‐Saavedra, Carlos Galliani, Fredy Chablé-Montero, Kristen A. Batich, Donald E. Henson,
Rokitansky-Aschoff sinuses (R-As) are epithelial invaginations that extend down the gallbladder wall through the smooth muscle gaps and by this pathway they reach the subserosal connective tissue. We report here 5 cases of mucin-containing R-As that ruptured, and as a result, extracellular mucin escaped into the adjacent stroma. They were compared with 10 mucinous carcinomas of the gallbladder. Three cases of mucin-containing R-As accompanied by abundant extracellular mucin deposits with epithelial ...
Tópico(s): Medical Imaging and Pathology Studies
2009 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Jorge Albores‐Saavedra, Mariana Weimersheimer-Sandoval, Fredy Chablé Montero, Daniel Montante-Montes de, Ralph H. Hruban, Donald E. Henson,
Foamy gland adenocarcinoma is a variant of pancreatic ductal carcinoma, whose precursor has not been described. We describe here the morphologic and immunohistochemical features of the pancreatic intraepithelial neoplasia (PanIN) lesions associated with invasive foamy pancreatic adenocarcinoma. The staining properties and morphologic and immunohistochemical features of 3 foamy PanIN lesions were compared with those of 7 pancreatic foamy gland adenocarcinomas. Hematoxylin and eosin, Mayer mucicarmine, ...
Tópico(s): Gastrointestinal Tumor Research and Treatment
2008 - Elsevier BV | Annals of Diagnostic Pathology
Arturo Angeles‐Angeles, Fredy Chablé-Montero, Braulio Martínez‐Benitez, Jorge Albores‐Saavedra,
We present 2 cases of papillary thyroid carcinoma (PTC) with conventional morphology that metastasized to unusual sites. The first neoplasm was a PTC whose initial clinical manifestation was a large metastasis in the pancreas which mimicked a primary neoplasm. The mediastinal location of the thyroid gland was responsible for the delay in identification of the primary tumor. Eventually, the patient, a 72-year-old man, developed brain and vertebral metastases. The second case was that of a 58-year- ...
Tópico(s): Biomarkers in Disease Mechanisms
2008 - Elsevier BV | Annals of Diagnostic Pathology
Jorge Albores‐Saavedra, Alexandra M. Hart, Fredy Chablé-Montero, Donald E. Henson,
Abstract Context.—Neuroendocrine tumors of the ampulla of Vater constitute a heterogeneous group of neoplasms clinically and morphologically. Because they are rare, little is known about their demo...
Tópico(s): Pancreatic and Hepatic Oncology Research
2010 - American Medical Association | Archives of Pathology & Laboratory Medicine
Jorge Albores‐Saavedra, Alexandra M. Hart, Fredy Chablé-Montero, Donald E. Henson,
Abstract Context.—Neuroendocrine tumors of the ampulla of Vater constitute a heterogeneous group of neoplasms clinically and morphologically. Because they are rare, little is known about their demographics and biologic behavior. Objective.—To analyze the demographics and the 5- and 10-year relative survival rates of 139 patients with carcinoid tumors and high-grade neuroendocrine carcinomas of the ampulla. Design.—Using data from National Cancer Institute's Surveillance, Epidemiology, and End Results ( ...
Tópico(s): Lung Cancer Research Studies
2010 - American Medical Association | Archives of Pathology & Laboratory Medicine
Jorge Albores‐Saavedra, Arnold M. Schwartz, Donald E. Henson, Lara E. Kostun, Alexandra M. Hart, David Angeles-Albores, Fredy Chablé-Montero,
Cutaneous angiosarcoma is an aggressive malignant mesenchymal vasoformative neoplasm that accounts for 1% of all soft tissue sarcomas. Using data from the National Cancer Institute's Surveillance, Epidemiology, and End Results program, we analyzed the demographics and survival of cutaneous angiosarcoma. The Surveillance, Epidemiology, and End Results program recorded 434 cases of cutaneous angiosarcoma from 1973 to 2007. The incidence was nearly the same in men (222 cases) and women (212 cases). Most ...
Tópico(s): CNS Lymphoma Diagnosis and Treatment
2010 - Elsevier BV | Annals of Diagnostic Pathology
Miguel A Tanimoto, Gonzalo Torres‐Villalobos, Rikiya Fujita, Patricio Santillán‐Doherty, Jorge Albores‐Saavedra, Fredy Chablé-Montero, Luis A. Martín-del-Campo, Lucia Vasquez, C.C. Bravo-Reyna, Octavio Villanueva, J J Villalobos, Misael Uribe, Miguel A. Valdovinos,
Aim. Evaluate the feasibility to overcome the learning curve in a western training center of the en bloc circumferential esophageal (ECE-) ESD in an in vivo animal model. Methods. ECE-ESD was performed on ten canine models under general anesthesia on artificial lesions at the esophagus marked with coagulation points. After the ESD each canine model was euthanized and surgical resection of the esophagus and stomach was carried out according to "the Principles of Humane Experimental Technique, Russel ...
Tópico(s): Esophageal Cancer Research and Treatment
2011 - Hindawi Publishing Corporation | Diagnostic and therapeutic endoscopy
Jorge Albores‐Saavedra, Fredy Chablé-Montero, David Angeles-Albores, Arnold M. Schwartz, David S. Klimstra, Donald E. Henson,
We report the clinicopathologic features of 13 cases of intramucosal carcinoma (IMC) of the gallbladder. All IMCs were incidental findings in cholecystectomy specimens for cholelithiasis. However, one of the patients had a carcinoma of the pancreas, and the gallbladder incidentally removed during the Whipple procedure showed an IMC. Another patient had a small cell carcinoma of the gallbladder, and one of the sections showed an IMC. Of the IMCs, 10 were well-differentiated adenocarcinomas, 1 was ...
Tópico(s): Pancreatic and Hepatic Oncology Research
2011 - Oxford University Press | American Journal of Clinical Pathology
Jorge Albores‐Saavedra, Fredy Chablé-Montero, Marco Aurelio González-Romo, Manuel Ramírez Jaramillo, Donald E. Henson,
We report 201 gallbladder adenomas from 91 patients most of whom were adult females. Fifty-three (58%) patients had gallstones. In 83 (91%) patients the adenomas were single. One gallbladder had 102 adenomas. Histologically, 165 (82%) of 201 adenomas were classified as pyloric, 28 (14%) as intestinal, 5 (2.4%) as foveolar, and 3 (1.4%) as biliary. Two patients had intestinal-type adenomas coexisting with biliary papillomatosis. Twenty-eight percent of pyloric gland adenomas contained squamoid morules. ...
Tópico(s): Gastric Cancer Management and Outcomes
2012 - Elsevier BV | Human Pathology
Jorge Albores‐Saavedra, Fredy Chablé-Montero, Nahúm Méndez‐Sánchez, Miguel Ángel Mercado, Mario Vilatobá‐Chapa, Donald E. Henson,
Carcinomas of the extrahepatic bile ducts are uncommon and morphologically heterogeneous. We report 3 unique examples of adenocarcinomas that show predominantly pyloric gland differentiation (80%-100%) and compare their immunohistochemical profile with that of pyloric gland adenomas of the gallbladder, foveolar, and intestinal-type adenocarcinomas of the extrahepatic bile duct. The 3 patients with pyloric gland adenocarcinomas were younger than those with conventional adenocarcinomas. The 3 tumors ...
Tópico(s): Galectins and Cancer Biology
2012 - Elsevier BV | Human Pathology
Fredy Chablé-Montero, Amy Shah BS, Daniel Montante-Montes de, Arturo Angeles‐Angeles, Donald E. Henson, Jorge Albores‐Saavedra,
We report the case of a 26-year-old woman with a 19 cm malignant hepatic neoplasm with morphological features that closely resembled a follicular thyroid carcinoma. Despite this, it was interpreted as a cholangiocarcinoma due to the absence of a primary thyroid tumor and the lack of thyroglobulin and TTF-1 immunoreactivity by the hepatic tumor. The left hepatic lobectomy specimen showed an encapsulated and multinodular gray-white mass with cystic and hemorrhagic areas. Microscopically, it displayed ...
Tópico(s): Medical Imaging and Pathology Studies
2012 - Elsevier BV | Annals of Hepatology
Jorge Albores‐Saavedra, Rita Dorantes-Heredia, Fredy Chablé-Montero, José Chanona-Vilchis, Delia Pérez‐Montiel, Leonardo S. Lino‐Silva, Marco Aurelio González-Romo, José Manuel Ramírez-Jaramillo, Donald E. Henson,
We describe the morphologic and immunohistochemical features of 17 endometrial stromal neoplasms, 16 sarcomas, and one stromal nodule.We reviewed 35 cases interpreted as endometrial stromal neoplasms, but 17 high-grade endometrial stromal sarcomas (ESS) and one case of mixed endometrial sarcoma and leiomyosarcoma were excluded from the study. Data from the Surveillance Epidemiology and End Results program on low- and high-grade ESS for 1973 through 2003 were obtained.One uterine primary ESS had collections ...
Tópico(s): Vascular Tumors and Angiosarcomas
2014 - Oxford University Press | American Journal of Clinical Pathology
José Manuel Ruiz-Morales, Rita Dorantes-Heredia, Fredy Chablé-Montero, Sara E. Vázquez-Manjarrez, Nahúm Méndez‐Sánchez, Daniel Motola‐Kuba,
Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver and is the fifth most common cancer in the world; its incidence has been increasing in recent years. Extrahepatic spread is present at the time of diagnosis in only about 5 to 15% of patients. Skeletal metastasis of HCC occurs less frequently compared with other cancers and is considered a rare primary form of presentation. We report two cases of unsuspected HCC presenting with multiple bone lesions as the initial presentation. ...
Tópico(s): Medical Imaging and Pathology Studies
2014 - Elsevier BV | Annals of Hepatology
Nancy Aguilar-Olivos, María del Carmen Manzano-Robleda, Ylse Gutiérrez-Grobe, Fredy Chablé-Montero, Jorge Albores‐Saavedra, Eric López-Méndez,
The differential diagnosis of fever of unknown origin (FUO) includes infectious, neoplastic, rheumaticinflammatory and miscellaneous diseases. We report the case of a 35-year-old man with FUO caused by Q fever. A liver biopsy showed the characteristic fibrin-ring lipogranulomas compatible with Q fever. The serologic tests confirmed the diagnosis of acute infection by Coxiella burnetii. The therapeutic response was excellent. In conclusion, we described a patient with acute Q fever and granulomatous ...
Tópico(s): Mosquito-borne diseases and control
2013 - Elsevier BV | Annals of Hepatology
María T. Bourlon, Mónica Sánchez-Ávila, Fredy Chablé-Montero, Ricardo Arceo-Olaiz,
IgG4-related disease (IgG4-RD) encompasses a wide range of extrapancreatic manifestations. Albeit some are relatively well known, others such as autoimmune prostatitis remain poorly described. We present a 61-year-old Latin-American male with autoimmune pancreatitis (AIP) who presented with lower urinary tract symptoms (LUTS), normal prostate specific antigen (PSA) test, and prostate enlargement attributed to benign prostatic hyperplasia (BPH). He underwent a transurethral resection of the prostate (TURP) ...
Tópico(s): Soft tissue tumor case studies
2013 - Hindawi Publishing Corporation | Case Reports in Urology
Jorge Albores‐Saavedra, Carlos Manivel, Rita Dorantes-Heredia, Fredy Chablé-Montero, César Godoy-Valdés, Carlos Chan-Núñez, Donald E. Henson,
Among 31 benign cystic neoplasms of the pancreas diagnosed as mucinous cystadenomas, we identified 9 (29%) cases of nonmucinous cystadenomas with a pancreatobiliary phenotype and an ovarian-like stroma. Although both cystic tumors belong to the same family, they should be separated because their epithelial lining and cyst fluid are different. The lining cells of the nonmucinous cystadenomas consisted of a single layer of cuboidal cells, similar to the epithelial cells of the normal pancreatic ducts, ...
Tópico(s): Gastrointestinal disorders and treatments
2013 - Oxford University Press | American Journal of Clinical Pathology
Paulina Chinchilla-López, Nancy Aguilar-Olivos, Jaime García-Gómez, Karen K. Hernández-Alejandro, Fredy Chablé-Montero, Daniel Motola‐Kuba, Tushar Patel, Nahúm Méndez‐Sánchez,
To investigate the prevalence, related risk factors, and survival of intrahepatic cholangiocarcinoma in a Mexican population. We conducted a cross-sectional study at Medica Sur Hospital in Mexico City with approval of the local research ethics committee. We found cases by reviewing all clinical records of inpatients between October 2005 and January 2016 who had been diagnosed with malignant liver tumors. Clinical characteristics and comorbidities were obtained to evaluate the probable risk factors ...
Tópico(s): Viral-associated cancers and disorders
2017 - Elsevier BV | Annals of Hepatology
Rita Dorantes-Heredia, Fredy Chablé-Montero, Donald E. Henson, Jorge Albores‐Saavedra,
We describe 8 cases of cholecystectomy specimens (6 laparoscopic and 2 open cholecystectomies) with Rokitansky-Aschoff (R-A) sinuses that were misinterpreted as adenocarcinomas. They were compared with 8 examples of classical R-A sinuses and 6 cases of R-A sinuses containing foci of adenocarcinoma. Five cases misinterpreted as adenocarcinomas consisted of densely packed, closely opposed R-A sinuses with little intervening stroma or surrounded by a desmoplastic stroma. They were lined by a single layer ...
Tópico(s): Cancer Diagnosis and Treatment
2013 - Lippincott Williams & Wilkins | The American Journal of Surgical Pathology
Gabriela Picón-Coronel, Fredy Chablé-Montero, Arturo Angeles‐Angeles, Jorge Albores‐Saavedra,
Well established complications of essential thrombocythemia are multiple thrombohemorrhagic phenomena in various abdominal organs. We describe the case of a 22 year old man with essential thrombocythemia and thrombosis of the mesenteric and splenic veins as well as cavernomatous transformation of the portal vein. The patient also had a splenic infarction and a subphrenic hematoma. Additionally, he developed signs and symptoms of acute cholecystitis which in turn led to an open cholecystectomy. The ...
Tópico(s): Gout, Hyperuricemia, Uric Acid
2011 - Elsevier BV | Annals of Hepatology
Fredy Chablé-Montero, Saulo Mendoza-Ramírez, María Isabel Lavenant-Borja, Marco Aurelio González-Romo, Virgilia Soto‐Abraham, Donald E. Henson, Jorge Albores‐Saavedra,
We report 3 patients all men between 45 and 64 years of age with unilocular or multilocular mucinous cystadenomas of the kidney. One tumor arose from the renal pelvis, and 2 involved the entire pyelocaliceal system. The tumors measured between 2.4 and 37 cm in greatest dimension. Two patients were asymptomatic, and 1 had recurrent attack of acute pyelonephritis. Microscopically, the morphology and immunophenotype (CK20, MUC2, and CDX2 positive) of the tumors were similar to the colonic adenomas. ...
Tópico(s): Intraperitoneal and Appendiceal Malignancies
2013 - Elsevier BV | Annals of Diagnostic Pathology
Itzayana Rodríguez‐Antonio, Guillermo Nahúm López-Sánchez, Victor Alfonso Reyes-Gómez, Ericka Contreras-Flores, Fernanda Farías-García, Mariana Espejel-Deloiza, Marco A. Durán-Padilla, Fredy Chablé-Montero, Misael Uribe, Norberto C. Chávez‐Tapia, Eduardo E. Montalvo‐Javé, Natalia Nuño‐Lámbarri,
Metabolic (dysfunction) associated fatty liver disease (MAFLD) and cholelithiasis are highly prevalent and are associated with common risk factors such as obesity, hypertriglyceridemia, and fasting glucose levels; however, it is not clear whether cholelithiasis is associated with MAFLD or fibrosis.To determine MAFLD severity and associated risk factors in patients diagnosed with cholelithiasis.Observational, cross-sectional and prolective study (from October 2018 to March 2020) of patients undergoing ...
Tópico(s): Gallbladder and Bile Duct Disorders
2021 - Elsevier BV | Annals of Hepatology
Jorge Zerón-Medina, Francisco Rodríguez‐Covarrubias, A. García-Mora, Manuel Guerrero Hernández, Fredy Chablé-Montero, Jorge Albores‐Saavedra, Heriberto Medina‐Franco,
Tópico(s): Oral and Maxillofacial Pathology
2011 - SAGE Publishing | The American Surgeon
Fredy Chablé-Montero, Arturo Angeles‐Angeles, Jorge Albores‐Saavedra,
Hepatic inflammatory myofibroblastic tumors are uncommon low grade malignant neoplasms. They can be confused clinically and by imaging studies with abscess.
Tópico(s): Pancreatitis Pathology and Treatment
2012 - Elsevier BV | Annals of Hepatology
Jorge Albores‐Saavedra, Rita Dorantes-Heredia, Fredy Chablé-Montero, Juan Carlos Córdova-Ramón, Donald E. Henson,
We describe 2 adult women (72 and 54 years), 1 with a low-grade noninvasive papillary urothelial carcinoma of the renal pelvis, who 14 years later developed a papillary carcinoma in 1 thyroid lobe and a medullary carcinoma in the contralateral lobe. Both neoplasms were similar in size and appeared symmetrical. Despite its small size, the medullary carcinoma metastasized in multiple cervical lymph nodes. The second patient had a high-grade invasive papillary urothelial carcinoma of the renal pelvis ...
Tópico(s): Renal cell carcinoma treatment
2014 - Elsevier BV | Annals of Diagnostic Pathology
Fredy Alvarado, Federico Escobar, Jorge Montero‐Muñoz,
Tópico(s): Plant and animal studies
2013 - Springer Science+Business Media | Organisms Diversity & Evolution
Arturo Angeles‐Angeles, Alfredo Reza‐Albarrán, Fredy Chablé-Montero, Juan Carlos Córdova-Ramón, Jorge Albores‐Saavedra, Braulio Martínez‐Benitez,
Phosphaturic mesenchymal tumor (PMT) is a morphologically heterogeneous soft tissue and bone neoplasm, producing a paraneoplastic syndrome due to phosphate wasting. These tumors produce fibroblast growth factor 23, which is implicated in renal tubule phosphate loss. Medical records of patients seen from 1999 to 2013 with osteomalacia associated or not with a tumor were reviewed. Clinical and laboratory data, radiographic studies, and follow-up of 8 patients were tabulated. Histologic features and ...
Tópico(s): Bone health and treatments
2015 - Elsevier BV | Annals of Diagnostic Pathology
Angï¿ ⁄ lica Morales‐Miranda, Ismael Domínguez-Rosado, Carlos Nï¿ ⁄ ï¿ ⁄ ez, Fredy Chablé Montero,
Approximately 15% of colorectal cancer (CRC) cases exhibit microsatellite instability (MSI), which appears to be associated with unique biological behavior. The present study presents a case of appendiceal carcinoma associated with MSI that responded well to adjuvant chemotherapy. Clinical, pathological and immunohistochemical (IHC) characteristics have been described. The 60-year-old male patient had suffered from recurrent lower abdominal pain associated with abdominal distention for 6 months; then, ...
Tópico(s): Ovarian cancer diagnosis and treatment
2018 - Spandidos Publishing | Molecular and Clinical Oncology