Firas Obaid Arhema Frejat, Yaquan Cao, Hongjin Zhai, Salah A. Abdel‐Aziz, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Chunli Wu,
DNA gyrase is a promising target for antibacterial agents. Several classes of small-molecule inhibitors have been discovered in recent decades, but none of these have reached the market. We have designed a small library of 1,2,4-oxadiazole/pyrrolidine hybrids with mid nanomolar inhibitory and potent antibacterial activities against DNA gyrase and topoisomerase IV. Compounds 9, 15, 16, 19, and 21 inhibited Escherichia coli DNA gyrase to a similar extent as the reference compound, novobiocin, with ...
Tópico(s): Synthesis and Biological Evaluation
2021 - Elsevier BV | Arabian Journal of Chemistry
Qais Hammouri, Abdalrazzaq Aloqool, Besan Abdallah Saleh, Hadeel Aldossary, Saleh Yahya al Frejat, Mona Halim, Dmaithan Almajali, Jassim Ahmad Al-Gasawneh, Saddam Rateb Darawsheh,
The increasing popularity of smartphones has led to the rise of e-wallets, which allow users to store their payment information on their devices and complete financial transactions conveniently and securely. This research extended the unified theory of acceptance and use of technology (UTAUT2) model to investigate the main factors influencing users’ intention to accept e-wallets in Jordan, where little research focused on such apps. Using a quantitative method, a sample of 181 users was utilized, ...
Tópico(s): Organizational and Employee Performance
2023 - Growing Science | International Journal of Data and Network Science
Yaquan Cao, Yingxue Yang, Maxwell Ampomah‐Wireko, Firas Obaid Arhema Frejat, Hongjin Zhai, Shuo Zhang, Huanhuan Wang, Yang Pu, Qingyan Yuan, Guanlian Wu, Chunli Wu,
In this study, a novel batch of indazole containing 1,2,3-triazole agents were designed and synthesized. The antiproliferative activity of target compounds in four human cancer cells, PC-3 (human prostate cancer cell), MCF-7 (human breast cancer cell), HepG-2 (human hepatoma cell) and MGC-803 (human gastric cancer cell), was evaluated by thiazole blue (MTT). In the antiproliferative activity screening, we were surprised to find that most compounds have specific cytotoxicity to PC-3 cancer cells. In particular, ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2022 - Elsevier BV | Bioorganic & Medicinal Chemistry Letters
Firas Obaid Arhema Frejat, Hongjin Zhai, Yaquan Cao, Lihong V. Wang, Yaser A. Mostafa, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Chunli Wu,
Tópico(s): Cancer therapeutics and mechanisms
2022 - Elsevier BV | Bioorganic Chemistry
Xian–Li Zhou, Firas Obaid Arhema Frejat, Wenliang Xu, Lianhai Shan,
Tópico(s): Advanced Synthetic Organic Chemistry
2017 - Elsevier BV | Heterocycles
Françoise Lelièvre, Philippe Berny, F. Buronfosse, Xavier Pineau, A. Frejat, François Lamarque,
... LELIEVRE, P. BERNY, F. BURONFOSSE, X. PINEAU, A. FREJAT and F. LAMARQUE. Toxicovigilance is a fairly new ...
Tópico(s): Pesticide Exposure and Toxicity
2001 - Ankara University | Revue Méd Vét
Firas Obaid Arhema Frejat, Yaquan Cao, Lihong Wang, Hongjin Zhai, Ahmed H. Abdelazeem, Hesham A. M. Gomaa, Bahaa G. M. Youssif, Chunli Wu,
A series of hybridized pyrrolidine compounds with a 1,2,4-oxadiazole moiety were synthesized to develop effective molecules against the enzymes DNA gyrase and topoisomerase IV (Topo IV). Compounds 8-20 were developed based on a previously disclosed series of compounds from our lab, but with small structural modifications in the hopes of increasing the compounds' biological activity. In comparison to novobiocin, with IC50 = 170 nM, the findings of the DNA gyrase inhibitory assay revealed that compounds ...
Tópico(s): Synthesis and Biological Evaluation
2022 - Wiley | Archiv der Pharmazie
Hongjin Zhai, Shuo Zhang, Maxwell Ampomah‐Wireko, Huanhuan Wang, Yaquan Cao, Yang Pu, Yingxue Yang, Firas Obald Arhema Frejat, Lihong V. Wang, Bing Zhao, Changzhong Ren, Chunli Wu,
Tópico(s): Cytokine Signaling Pathways and Interactions
2022 - Pleiades Publishing | Russian Journal of Bioorganic Chemistry
Amir Mor‐Mussery, David Helman, Yael Agmon, Itsik Ben‐Shabat, Salem El‐Frejat, Deborah Goldman Golan,
Abstract The Negev suffers from enhanced land degradation, mostly due to lack of awareness about its state, and hostility between the region's indigenous Bedouin farmers and the authorities. In order to examine a potential solution to this 'Lose–Lose' situation, a unique project is underway, with the collaboration of the Yeroham Municipality and the adjacent Rahma Bedouin farmers' village. The concept of this ongoing Programme is based on bidirectional knowledge transfer of farming data between the ...
Tópico(s): Archaeology and Historical Studies
2020 - Wiley | Land Degradation and Development
Hongjin Zhai, Chunying Luo, Yang Pu, Shuo Zhang, Huanhuan Wang, Yaquan Cao, Yingxue Yang, Haoyue Liu, Xiaoyan Kong, Firas Obald Arhema Frejat, Changzhong Ren, Xiufang Shi, Chunli Wu,
With the increasing incidence of antibiotic resistance, there is an urgent need to develop new antibiotics with excellent activity against drug-resistant bacteria. Three novel series of tylosin semisynthetic derivatives were designed, synthesized and evaluated for their antibacterial activities against various Gram-positive and Gram-negative bacteria. Among these derivatives, compound C-2 demonstrated potent antibacterial activity against both gram-positive and gram negative bacteria, and non mutagenic. ...
Tópico(s): Synthesis and Biological Evaluation
2022 - Elsevier BV | European Journal of Medicinal Chemistry
Suha Mujahed Abudoleh, Amal Al Mahayreh, Aya Al Frejat, Fatima Al Hulaisy, Sara O. Hamdan,
Concrete is considered as the most widely used construction material in the world. However, concrete is exposed to cracks due to different factors like overloads, temperature, shrinkage, earthquakes and others. These cracks reduce the strength, the service life of the structure, and increase the permeability of the concrete. Thus, the importance of "self-healing concrete" is highlighted nowadays, with emphasis on a special type of concrete called bioconcrete, which is a concrete that has the ability ...
Tópico(s): Synthetic Organic Chemistry Methods
2019 - EDP Sciences | MATEC Web of Conferences
Mutaz Al-Frejat, Mohammad HjoujBtoush,
Computerized tomography (CT) images contribute immensely to medical research and diagnosis. However, due to degradative factors such as noise, low contrast, and blurring, CT images tend to be a degraded representation of the actual body or part under investigation. To reduce the risk of imprecise diagnosis associated with poor-quality CT images, this paper presents a new technique designed to enhance the quality of medical CT images. The main objective is to improve the appearance of CT images in ...
Tópico(s): Advanced Image Fusion Techniques
2016 - Science and Information Organization | International Journal of Advanced Computer Science and Applications
... . Leacock, 82. See also 64. José Frejat, ‘Brasilianas’, O Semanário, May 10, 1962, 2. 65 ...
Tópico(s): Brazilian cultural history and politics
2023 - Routledge | The International History Review
... from time to time (Epstein, 1955; Heintze, 1961; Frejat et al. 1967). The objective of the present ...
Tópico(s): Plant Micronutrient Interactions and Effects
1969 - Madras Agricultural Students Union | Madras Agricultural Journal
Zyad Al-Frejat, Nafiza Martini, A.M. Esper, Diana Al-Frejat, Samer Younes, Majd Hanna,
GERD is a very familiar diagnosis among health care providers due to its massive spread, and its symptoms can affect the quality of life for a respectable slice of its patients. Therefore, what can only be described as a logical consequence, a pursuit of a treatment that can both relieve symptoms and have minimal side effects is still ongoing to cover the large demographic affected by GERD. In the following review, analysis will be made of GERD, including possible regulatory activity, of certain ...
Tópico(s): Gastrointestinal motility and disorders
2024 - Elsevier BV | Current Research in Pharmacology and Drug Discovery
Zhengmin Fan, Zhaiwei Lin, Hongjin Zhai, Yaquan Cao, Huanhuan Wang, Aichata Maiga, Firas Obald Arhema Frejat, Changzhong Ren, Chunli Wu,
The widespread use of tylosin family drugs in clinical practice has led to bacterial resistance and reduced therapeutic efficacy. We designed and synthesized a series of new semisynthetic derivatives of tylosin with 5-O-mycaminosyltylonolide as the mother nucleus, mainly by introducing a variety of amino groups at its C-23 position. Some of the compounds showed high antibacterial activity against Gram-negative and Gram-positive bacteria. These findings indicate that the best compound, c9, possessed ...
Tópico(s): Pneumocystis jirovecii pneumonia detection and treatment
2024 - American Chemical Society | ACS Medicinal Chemistry Letters
Majd Omoush, Ala'a Sulieman Al-frejat, Ra’ed Masa'deh,
Purpose This paper aims to systematically review the literature on digital supply chain (DSC), big data (BD) and manufacturing lead time (MLT) in industrial companies. Design/methodology/approach This study provides a systematic review of the 99 research on this subject that was published between 2015 and 2022. Studies were found in the Scopus database. This review also identifies gaps in the literature, highlights conflicting results, examines prospective data sources for empirical researchers and ...
Tópico(s): Economic and Technological Systems Analysis
2024 - Emerald Publishing Limited | Business Process Management Journal
Ewing sarcoma is an aggressive tumor characterized by small round cells and diffuse CD99 positivity seen mainly in Caucasian childhood and adolescent demographics. Ewing sarcoma of spinal origin accounts for approximately 3-9 % of cases most of these cases affecting the sacrum, therefore lumbar lesions are considered quite rare.
Tópico(s): Management of metastatic bone disease
2024 - Elsevier BV | International Journal of Surgery Case Reports
Hongjin Zhai, Zi-Wei Lin, Zhengmin Fan, Huanhuan Wang, Firas Obald Arhema Frejat, Yingxue Yang, Yaquan Cao, Chunli Wu,
Tópico(s): Animal Nutrition and Physiology
2023 - Pleiades Publishing | Russian Journal of Bioorganic Chemistry
Produção Nacional
Fernando Pavie Frejat, Fábio Cordeiro de Lisboa,
This work aims to implement a measurement system for the airflow of an EA211 1.0 MPI Volkswagen engine.Based on the theoretical basis of mass flow calculation, a system was implemented in the laboratory that allowed obtaining, through the difference in pressure and air velocity and using ways to calibrate the measuring nozzle, the discharge coefficient of the entire system.From these data, it was possible to obtain the theoretical and absolute values of the mass flow of air entering the engine.With ...
Tópico(s): Vehicle emissions and performance
2023 - | Journal of Engineering Research
Frias Obaid Arhema Frejat, Bing Zhao, Nooruldeen Furaijit, Lihong Wang, Hesham A. Abou‐Zied, Hazem M. Fathy, Fatma A. Mohamed, Bahaa G. M. Youssif, Chunli Wu,
Abstract Cancer is one of the leading causes of mortality worldwide, making it a public health concern. A novel series of pyrrolidine‐carboxamide derivatives 7a‐q were developed and examined in a cell viability assay utilizing a human mammary gland epithelial cell line (MCF‐10A), where all the compounds exhibited no cytotoxic effects and more than 85% cell viability at a concentration of 50 μM. Antiproliferative activity was evaluated in vitro against four panels of cancer cell lines A‐549, MCF‐7, ...
Tópico(s): Cancer therapeutics and mechanisms
2023 - Wiley | Chemical Biology & Drug Design