J. Thomas Rimer, Van C Gessel,
... Past in Traditional Forms Baba Akiko Kaneko Tota Nakajo Fumiko Drama Betsuyaku Minoru The Little Match Girl Kinoshita ...
Tópico(s): Themes in Literature Analysis
2012 - Association of College and Research Libraries | Choice Reviews Online
Fumitaka Ejima, Yoshihiko Fukukura, Kiyohisa Kamimura, Masatoyo Nakajo, Takuro Ayukawa, Fumiko Kanzaki, Shintaro Yanazume, Hiroaki Kobayashi, Ikumi Kitazono, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura,
Background Oscillating gradient diffusion‐weighted imaging (DWI) enables elucidation of microstructural characteristics in cancers; however, there are limited data to evaluate its utility in patients with endometrial cancer. Purpose To investigate the utility of oscillating gradient DWI for risk stratification in patients with uterine endometrial cancer compared with conventional pulsed gradient DWI. Study Type Retrospective. Subjects Sixty‐three women (mean age: 58 [range: 32–85] years) with endometrial ...
Tópico(s): Endometrial and Cervical Cancer Treatments
2023 - Wiley | Journal of Magnetic Resonance Imaging
Seiji Shioda, Hirokazu Ohtaki, Tomoya Nakamachi, Kenji Dohi, Jun Watanabe, Shigeo Nakajo, Satoru Arata, Shinji Kitamura, Hiromi Okuda, Fumiko Takenoya, Yoshitaka Kitamura,
Abstract: Pituitary adenylate cyclase‐activating polypeptide (PACAP) is a pleiotropic neuropeptide that belongs to the secretin/glucagon/vasoactive intestinal peptide (VIP) family. PACAP prevents ischemic delayed neuronal cell death (apoptosis) in the hippocampus. PACAP inhibits the activity of the mitogen‐activated protein kinase (MAPK) family, especially JNK/SAPK and p38, thereby protecting against apoptotic cell death. After the ischemia‐reperfusion, both pyramidal cells and astrocytes increased ...
Tópico(s): Apelin-related biomedical research
2006 - Wiley | Annals of the New York Academy of Sciences
Nobuo Kanazawa, Fumiko Honda‐Ozaki, Megumu K. Saito,
Nakajo-Nishimura syndrome is a proteasome-associated autoinflammatory syndrome with a distinct homozygous mutation in the PSMB8 gene encoding an inducible β5i subunit of the immunoproteasome. Although it is considered that immunoproteasome dysfunction causes cellular stress and contributes to the production of inflammatory cytokines and chemokines, its detailed mechanism is still unknown. On the other hand, hereditary autoinflammatory diseases are considered as a good target for the analyses using ...
Tópico(s): Immune Response and Inflammation
2019 - BioMed Central | Inflammation and Regeneration
Fumiko Honda‐Ozaki, Madoka Terashima, Akira Niwa, Norikazu Saiki, Yuri Kawasaki, Haruna Ito, Akitsu Hotta, Ayako Nagahashi, Koichi Igura, Isao Asaka, Hongmei Lisa Li, Masakatsu Yanagimachi, Fukumi Furukawa, Nobuo Kanazawa, Tatsutoshi Nakahata, Megumu K. Saito,
Nakajo-Nishimura syndrome (NNS) is an immunoproteasome-associated autoinflammatory disorder caused by a mutation of the PSMB8 gene. Although dysfunction of the immunoproteasome causes various cellular stresses attributed to the overproduction of inflammatory cytokines and chemokines in NNS, the underlying mechanisms of the autoinflammation are still largely unknown. To investigate and understand the mechanisms and signal pathways in NNS, we established a panel of isogenic pluripotent stem cell (PSC) ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2018 - Elsevier BV | Stem Cell Reports
Kayo Kunimoto, Fumiko Honda‐Ozaki, Megumu K. Saito, Fukumi Furukawa, Nobuo Kanazawa,
... effect of methotrexate on a child case of Nakajo–Nishimura syndrome Kayo Kunimoto, Kayo Kunimoto orcid.org/0000-0001-8102-1193 Department of Dermatology, Wakayama Medical University, Wakayama, JapanSearch for more papers by this authorFumiko Honda-Ozaki, Fumiko Honda-Ozaki Department of Clinical Application, Center for ...
Tópico(s): RNA regulation and disease
2019 - Wiley | The Journal of Dermatology
Naoya Kase, Madoka Terashima, Akira Ohta, Akira Niwa, Fumiko Honda‐Ozaki, Yuri Kawasaki, Tatsutoshi Nakahata, Nobuo Kanazawa, Megumu K. Saito,
Abstract Nakajo-Nishimura syndrome (NNS) is an autoinflammatory disorder caused by a homozygous mutations in the PSMB8 gene. The administration of systemic corticosteroids is partially effective, but continuous treatment causes severe side effects. We previously established a pluripotent stem cell (PSC)-derived NNS disease model that reproduces several inflammatory phenotypes, including the overproduction of monocyte chemoattractant protein-1 (MCP-1) and interferon gamma-induced protein-10 (IP-10). ...
Tópico(s): Immunotherapy and Immune Responses
2020 - Wiley | Stem Cells Translational Medicine
Seiji Shioda, Hirokazu Ohtaki, Ryusuke Suzuki, Tomoya Nakamachi, Fumiko Takenoya, Kenji Dohi, Shigeo Nakajo,
PACAPによる海馬細胞死防御とその分子制御機構について,機能形態学的方法を用いて調べた.ラットおよびマウスの虚血-再灌流モデルでは,海馬領域の特にCA1の神経細胞が多数遅発性細胞死をおこす.超微量(pM, nMオーダー)のPACAPを脳室内および静脈内投与すると,この遅発性神経細胞死は著明に抑制されることが明らかになった.さらに,再灌流1日後からPACAPを脳室内および静脈内投与しても神経細胞死を有意に抑制することが明らかになった.また神経細胞死のおきる部位に一致して星状膠細胞にPACAP受容体が強く発現した.また,外傷モデルのEGFP-GFAPトランスジェニックマウスでも,虚血実験と同じく星状膠細胞にPACAP受容体が特異的に発現した.さらに細胞死のシグナル伝達系路として最も重要であると考えられているMAPキナーゼカスケードについて虚血モデル動物の海馬領域を採取して調べたところ,神経細胞死とともにこの系路が活性化しているのが明らかになった.PACAPはこの系路を介して遅発性神経細胞死を抑制することが明らかになった.また,PACAPによる虚血性神経細胞死抑制作用として,PACAPが星状膠細胞を刺激してIL- ...
Tópico(s): Pharmacological Receptor Mechanisms and Effects
2004 - Japanese Pharmacological Society | Folia Pharmacologica Japonica
Koji Takumi, Ryota Nakanosono, Hiroaki Nagano, Hiroto Hakamada, Fumiko Kanzaki, Kiyohisa Kamimura, Masatoyo Nakajo, Yukari Eizuru, Hiromi Nagano, Takashi Yoshiura,
Abstract Purpose To determine whether synthetic MR imaging can distinguish between benign and malignant salivary gland lesions. Methods The study population included 44 patients with 33 benign and 11 malignant salivary gland lesions. All MR imaging was obtained using a 3 Tesla system. The QRAPMASTER pulse sequence was used to acquire images with four TI values and two TE values, from which quantitative images of T1 and T2 relaxation times and proton density (PD) were generated. The Mann–Whitney U ...
Tópico(s): Bone Tumor Diagnosis and Treatments
2024 - Springer Science+Business Media | Japanese Journal of Radiology
Kayo Kunimoto, Fumiko Ozaki, Fukumi Furukawa, Nobuo Kanazawa,
Nakajo-Nishimura syndrome (NNS) is a very rare autosomal recessively-inherited autoinflammatory disorder that onsets in infancy with pernio-like rashes and gradually develops into partial lipodystrophy, accompanied with remittent fever and nodular skin eruptions. This disease is caused by a unique mutation of the PSMB8 gene, which not only impairs an enzymatic activity of the encoding beta5i subunit, but also disturbs formation of the immunoproteasome complex. As the pathogenesis for NNS, cellular ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2015 - BioMed Central | Pediatric Rheumatology
Kayo Kunimoto, Fumiko Ozaki, Fukumi Furukawa, Nobuo Kanazawa,
Tópico(s): Immune Response and Inflammation
2016 - Elsevier BV | Journal of Dermatological Science
Koji Takumi, Hiroto Hakamada, Hiroaki Nagano, Ryota Nakanosono, Fumiko Kanzaki, Masanori Nakajo, Kiyohisa Kamimura, Masatoyo Nakajo, Daigo Nagano, Kazuhiro Ueda, Takashi Yoshiura,
Tópico(s): Pituitary Gland Disorders and Treatments
2025 - Elsevier BV | European Journal of Radiology
Kiyohisa Kamimura, Tetsuo TOKUDA, Junki Kamizono, Tsubasa Nakano, Tomohito Hasegawa, Masanori Nakajo, Fumitaka Ejima, Fumiko Kanzaki, Koji Takumi, Masatoyo Nakajo, Shingo Fujio, Ryosuke Hanaya, Akihide Tanimoto, Takashi Iwanaga, Hiroshi Imai, Thorsten Feiweier, Takashi Yoshiura,
Background and Purpose Differentiation between functioning and nonfunctioning pituitary adenomas/pituitary neuroendocrine tumors (PAs) is clinically relevant. The goal of this study was to determine the feasibility of using time‐dependent diffusion MRI (dMRI) for microstructural characterization of PAs. Methods The study included 54 participants, 24 with functioning PA and 30 with nonfunctioning PA. Time‐dependent dMRI of the pituitary gland was performed using an inner field‐of‐view echo‐planar imaging ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2024 - Wiley | Journal of Neuroimaging
Hiroaki Nagano, Koji Takumi, E. Nagano, Ryota Nakanosono, Masatoyo Nakajo, Kiyohisa Kamimura, Masanori Nakajo, Fumiko Kanzaki, Fumitaka Ejima, Takuro Ayukawa, Tomohito Hasegawa, Tsubasa Nakano, Mitsuho Hirahara, Takashi Yoshiura,
Tópico(s): Cardiac Imaging and Diagnostics
2025 - Springer Science+Business Media | Japanese Journal of Radiology
Nobuo Kanazawa, Fumiko Honda‐Ozaki, M. Terashima, Akira Niwa, Masakatsu Yanagimachi, Fukumi Furukawa, Tatsutoshi Nakahata, Megumu K. Saito,
Nakajo-Nishimura syndrome (NNS) is an immunoproteasome-associated autoinflammatory disorder caused by a mutation of the PSMB8 gene. Although dysfunction of the immunoproteasome causes various cellular stresses attributed to the overproduction of inflammatory cytokines and chemokines in NNS, the underlying mechanisms of the autoinflammation are still largely unknown. To investigate and understand the mechanisms and signal pathways in NNS, we established a panel of isogenic pluripotent stem cell (PSC) ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2018 - Elsevier BV | Journal of Investigative Dermatology
Nobuo Kanazawa, Yumi Nakatani, Yutaka Inaba, Kayo Kunimoto, Fukumi Furukawa, Fumiko Ozaki,
In Nakajo-Nishimura syndrome (NNS), proteasome disability due to a loss-of-function PSMB8 mutation induces storage of ubiquitinated proteins and overproduction of inflammatory cytokines and chemokines. However, the precise mechanisms causing complex phenotypes of the disease, including pernio-like eruptions, lipodystrophy and calcification of basal ganglia, is mostly unclear. As IL-6 overproduction in association with p38 hyperactivation was supposed to have a role in NNS (Arima et al., PNAS 2011), ...
Tópico(s): Transplantation: Methods and Outcomes
2016 - Elsevier BV | Journal of Dermatological Science
Nobuo Kanazawa, Yumi Nakatani, Yutaka Inaba, Kayo Kunimoto, Fukumi Furukawa, Fumiko Ozaki,
In Nakajo-Nishimura syndrome (NNS), proteasome disability due to a loss-of-function PSMB8 mutation induces storage of ubiquitinated proteins and overproduction of inflammatory cytokines and chemokines. However, the precise mechanisms causing complex phenotypes of the disease, including pernio-like eruptions, lipodystrophy and calcification of basal ganglia, is mostly unclear. As IL-6 overproduction in association with p38 hyperactivation was supposed to have a role in NNS (Arima et al, PNAS 2011), ...
Tópico(s): Neutrophil, Myeloperoxidase and Oxidative Mechanisms
2015 - BioMed Central | Pediatric Rheumatology
Koji Takumi, Hiroaki Nagano, Yoshiki Kamimura, Kazuhiro Ueda, Tadashi Umehara, Go Kamimura, Ryota Nakanosono, Masatoyo Nakajo, Kiyohisa Kamimura, Fumiko Kanzaki, Takashi Yoshiura,
Tópico(s): Cardiac Valve Diseases and Treatments
2025 - Nature Portfolio | Scientific Reports
Background Nakajo-Nishimura syndrome (NNS) is an immunoproteasome-associated autoinflammatory disorder caused by a mutation of PSMB8 gene. 1 ... 141(1):339–349. Acknowledgements We thank Dr. Fumiko Honda-Ozaki and Ms Madoka Terashima for conducting ...
Tópico(s): Acute Myeloid Leukemia Research
2018 - BMJ | Annals of the Rheumatic Diseases
Masatoyo Nakajo, Daisuke Hirahara, Megumi Jinguji, Mitsuho Hirahara, Atsushi Tani, Hiromi Nagano, Koji Takumi, Kiyohisa Kamimura, Fumiko Kanzaki, Masaru Yamashita, Takashi Yoshiura,
Abstract Objectives To develop and identify machine learning (ML) models using pretreatment 2-deoxy-2-[ 18 F]fluoro-D-glucose ([ 18 F]-FDG)-positron emission tomography (PET)-based radiomic features to differentiate benign from malignant parotid gland diseases (PGDs). Materials and methods This retrospective study included 62 patients with 63 PGDs who underwent pretreatment [ 18 F]-FDG-PET/computed tomography (CT). The lesions were assigned to the training ( n = 44) and testing ( n = 19) cohorts. In total, 49 [ 18 ...
Tópico(s): Head and Neck Cancer Studies
2024 - Springer Science+Business Media | Japanese Journal of Radiology
Sélima Fourati Ben Mustapha, Mariem Khrouf, K. Kacem Ben Rejeb, H. Elloumi Chaabene, Ghaya Merdassi, D. Wahbi, Mounir Ben Meftah, F. Zhioua, A. Zhioua, A. Azzarello, T. Host, Anne Lis Mikkelsen, Charlampos Theofanakis, Vasiliki Dinopoulou, Despoina Mavrogianni, George A. Partsinevelos, Petros Drakakis, Konstantinos Stefanidis, Athanasia Bletsa, D. Loutradis, Laura Rienzi, Antonio Cobo, A. Paffoni, C. Scarduelli, Antonio Capalbo, Nicolás Garrido, J. Remohı́, G. Ragni, Filippo Maria Ubaldi, R. Herrer, M. Quera, Esther Gil, J L De la Serna, Marie Louise Grøndahl, Jeanette Bogstad, I. Agerholm, J. G. Lemmen, Ursula Bentin-Ley, P. Lundstrom, Ulrik Schiøler Kesmodel, M. Raaschou-Jensen, Steen Ladelund, L. Guzman, Carolina García de Grijalba Ortega, F. K. Albuz, Robert B. Gilchrist, Paul Devroey, Johan Smitz, Michel De Vos, M. Bielanska, Marie-Claude Léveillé, E. Borghi, Maria Cristina Magli, Margot Figueroa, G. Mascaretti, A. P. Ferraretti, Luca Gianaroli, E. Szlit, Francisco Leocata Nieto, G. Maggiotto, Gabriel Arenas, N. Tarducci Bonfiglio, Ana Carolina Ahumada, Rachel Asch, Romualdo Sciorio, N. Dayoub, J.F. Thong, Susanne Pickering, J. I. Ten, M. A. Carracedo, Juan Carlos Hernández‐Guerrero, Adoración Rodríguez-Arnedo, J. Llácer, Rafael Bernabéu, Carla Tatone, T. Heizenrieder, Giovanna Di Emidio, P. Treffon, T. Seidel, Ursula Eichenlaub-Ritter, Sylvia Sanches Cortezzi, E Cabral, Christina R. Ferreira, Maurizio Trevisan, R. C. S. Figueira, D. P. A. F. Braga, Marcos N. Eberlin, Assumpto Iaconelli, E. Borges, Ane Fullaondo, T. Pessino, Léonardo Blanco, G. Rey Valzacchi, F. Leocata, Ana Carolina Ahumada, Frauke Vanden Meerschaut, B. Heindryckx, C. Qian, D. Deforce, Luc Leybaert, P. De Sutter, M. De las Heras, Juan Pablo, B. Navarro, J. A. Agirregoikoa, G. Barrenetxea, M. Cruz, I. Perez-Cano, B. Gadea, J. Herrero, M. Martinez, M. Roldan, María Paz Muñoz, António Pellicer, Marcos Meseguer, María Paz Muñoz, M. Cruz, M. Roldan, B. Gadea, N. Galindo, M. Martinez, António Pellicer, M. Meseguer, I. Perez-Cano, Filomena Scarselli, Erminia Alviggi, A. Colasante, M. G. Minasi, P. Rubino, M. Lobascio, Simone Ferrero, Katarzyna Litwicka, M. T. Varricchio, P. Giannini, Pamela Piscitelli, G. Franco, D. Zavaglia, Z.P. Nagy, E. Greco, F. Urner, Daniel Wirthner, Frédéric Murisier, P. Möck, M. Germond, B. Amorocho Llanos, G. Calderon, Derrick Lopez, L. Fernandez, M. Nicolas, J. Landeras, Sarah Finn‐Sell, R. Leandri, Tom Fleming, N.S. Macklon, Ying Cheong, Judith J. Eckert, J. H. Lee, Y. J. Jung, H. K. Hwang, A H Kang, S.J. An, J. Y. Jung, H. C. Kwon, S. J. Lee, Simone Palini, Lello Zolla, Stefania Stefani, Vincenzo Scala, Anthony M. D’Alessandro, V. Polli, Paolo Rocchi, A. Tiezzi, Emanuele Pelosi, L. Dusi, C. Bulletti, R. Fadini, M. Lain, M. Mignini Renzini, F. Brambillasca, Giovanni Coticchio, M. Merola, M. C. Guglielmo, Mariabeatrice Dal Canto, R. C. S. Figueira, A. S. Setti, D. P. A. F. Braga, Assumpto Iaconelli, E. Borges, K.C. Worrilow, Chizoba D Uzochukwu, Sherrine Eid, Séverine Le Gac, Telma C. Esteves, F. van Rossem, A. van den Berg, M. Boiani, E. Kasapi, Yannis Panagiotidis, M. Goudakou, Achilleas Papatheodorou, T. Pasadaki, Νικόλαος Πράπας, Yannis Prapas, Yannis Panagiotidis, E. Kasapi, M. Goudakou, Achilleas Papatheodorou, T. Pasadaki, P. Vanderzwalmen, Νικόλαος Πράπας, Yannis Prapas, S. Norasing, P Atchajaroensatit, W. Tawiwong, O. Thepmanee, S. Saenlao, J. Aojanepong, P. Hunsajarupan, K. Sajjachareonpong, P. Punyatanasakchai, S. Maneepalviratn, U. Jetsawangsri, J. Herrero, M. Cruz, A. Tejera, Irene Martín Rubio, J. L. Romero, Marcos Meseguer, Verena Nordhoff, Stefan Schlatt, Andreas N. Schüring, Ludwig Kiesel, Sabine Kliesch, Roberto Doglia Azambuja, L. Okada, V. Lazzari, L. Dorfman, J. Michelon, M. Badalotti, F. Badalotti, A. Petracco, Christoph Schwarzer, Telma C. Esteves, Verena Nordhoff, Stefan Schlatt, M. Boiani, K. Versieren, B. Heindryckx, I. De Croo, Sylvie Lierman, W. De Vos, E. Van den Abbeel, Jan Gerris, P. De Sutter, I. Milacic, D. Borogovac, M. Veljkovic, Branko Arsić, Djordje Bojovic, Dragana Lekić, Djordje Pavlovic, E. Garalejic, M. C. Guglielmo, Giovanni Coticchio, David F. Albertini, Mariabeatrice Dal Canto, F. Brambillasca, M. Mignini Renzini, E. De Ponti, R. Fadini, F. Sanges, R. Talevi, Antonio Capalbo, Laura Papini, Vanina Mollo, F. M. Ubaldi, Laura Rienzi, R. Gualtieri, F. K. Albuz, L. Guzman, C. Orteg, Robert B. Gilchrist, Paul Devroey, Michel De Vos, Johan Smitz, James P. Choi, H. Lee, Seung‐Yup Ku, S. Kim, Yoo Duk Choi, J. Kim, Sang Hui Moon, E. Demilly, S. Assou, S. Moussaddykine, H. Déchaud,
Oxford University Press
Ajiro Kozo, An Songzhu, Armand Sylvie, Mario Ascoli, Ave ́ret, Rana Awwad, Arnold Baas, James Baleja, Vimla Band, Michael Barnes, Cary B. Bauer, Jacques Benen, Bridget Berechid, Erhard Bieberich, Anne‐Marie Birot, Alessandro Bisello, Jan Blaauwen, Michael Blackman, Christian Blouin, Barry J. Bowman, Emma Jean Bowman, S N Boyer, Brando The, Andreas Braunwarth, Kristie Grove Bridges, Pierre Bruhns, Steven J. Burakoff, Angela Campbell, Steven Carlson, Carlos J. Carrera, Dennis A. Carson, Christopher Chang, Talal - Chatila, Thomas C. Chou, Antonella Circolo, Donald Coen, Conan Cooper, Jackie Corbin, Howard B. Cottam, Susan Craig, Dae ̈ron, Charles E. Dahl, Gretchen Darlington, Wafik S. El‐Deiry, George Demartino, Laxminarayana R. Devireddy, Daniel C. Devor, Ba Diaz, Bauke Dijkstra, Roel van Driel, Druker Brian Van, Prem Dwivedi, E Larson Christopher, Rosalind P. Fabunmi, Richard W. Farndale, Paul J. Farrell, Antonio Feliciello, M. Ferrazzi, Eric Feyfant, Gary L. Firestone, Paul B. Fisher, Eric Fontain, Franzoso Guido, Frelin Christian, Perry Frey, S. Frey, Michelle Jones, Philipp J. Kahle, Sang Hoon Kang, Gregory S. Kelner, Ryan Kendle, H.C.M. Kester, Kay‐Hooi Khoo, Jaehwan Kim, Kimura-Someya Tomomi, George Klarmann, Caroline Knight, Michel H. J. Koch, Tomoko Kodaka, Ismail Kola, Sachiko Kondo, Ko ̈nig, Ku ̈nzler, Do Young Kwon, Labbe ́-Jullie ́, Annie Ladoux, Denise Lau, Donna Lee, Virginia Lee, Marie Lenoir, Peter J. Lenting, Antonio Leonardi, Lorenzo M. Leoni, Duan‐Fang Liao, Paul B. Lieberman, Nancy L. Lill, Bryan Linggi, Chau Lo, Rita Lo, Mark Lupher, Dominique Maciejewski, Kathryn Macleod, Jean-Pierre Magaud, Richard Maki, Fumiko Matsui, Doug Mcgrath, Keith Mclarren, Evelina Mele, Roberto Minafra, Jeffrey Miner, Mitchell Kyran, Masako Miyahara, Sachiko Miyake, Tomoyuki Miyashita, Peter Moody, Guillermo Morales, Anne‐Pierre Morel, Nakajo Shigeo, Amy Vagi, Marilena Di, Karen L. Valentino, Elena Vasilyeva, Johan van der Vlag, John E. Volanakis, ́j Matthe, Keizo Waku, W Henderson Kenneth, Weichselbaum Ralph, Michael Weiss, Jeffrey A. Whitsett, William A. Christian, Steven Hsu, Barrie Wilkinson, Kai W. Wucherpfennig, Ken-Ichi Yagami, Yoshida Kiyotsugu, Ralph G. Yount, Zhi-Min Yuan, Cheng Zhang, Sharleen Zhou,
2000 - Elsevier BV | Journal of Biological Chemistry