Viktor Szegedi, Gábor Juhász, Éva Rózsa, Gabriella Juhász-Vedres, Zsolt Datki, Lívia Fülöp, Zsolt Bozsó, Andrea Lakatos, Ilona Laczkó, T. Farkas, Zsolt Kis, Géza Tóth, Katalin Soós, Márta Zaráindi, Dénes Budai, József Toldi, Botond Penke, Viktor Szegedi, Gábor Juhász, Éva Rózsa, Gabriella Juhász-Vedres, Zsolt Datki, Lívia Fülöp, Zsolt Bozsó, Andrea Lakatos, Ilona Laczkó, Tamás Farkas, Zsolt Kis, Géza Tóth, Katalin Soós, Márta Zaráindi, Dénes Budai, József Toldi, Botond Penke,
The underlying cause of Alzheimer's disease (AD) is thought to be the beta-amyloid aggregates formed mainly by Abeta1-42 peptide. Protective pentapeptides [e.g., Leu-Pro-Phe-Phe-Asp (LPFFD)] have been shown to prevent neuronal toxicity of Abeta1-42 by arresting and reversing fibril formation. Here we report that an endogenous tetrapeptide, endomorphin-2 (End-2, amino acid sequence: YPFF), defends against Abeta1-42 induced neuromodulatory effects at the cellular level. Although End-2 does not interfere ...
Tópico(s): Supramolecular Self-Assembly in Materials
2006 - Wiley | The FASEB Journal