Eric L. Piza, David N. Hatten, George Mohler, Jeremy G. Carter, Jisoo Cho,
... gun violence prevention effect of gunshot detection technology (GDT) in Kansas City, MO. We measure the influence of GDT on process measures (ballistic evidence collection and gun ... assaults and robberies committed with a firearm). The GDT system was associated with higher levels of ballistic evidence collection in the GDT target area and surrounding catchment area, higher levels ... of shots fired calls for service in the GDT target area. The GDT system did not influence any of the gun ... discharges may consider dedicating necessary resources to acquire GDT. Agencies that prioritize the reduction of gun violence ...
Tópico(s): Traffic and Road Safety
2023 - Wiley | Criminology & Public Policy
Springer Link
Nienke de Graeff, Karin Jongsma, Annelien L. Bredenoord,
Abstract Background Gene drive technologies (GDTs) promote the rapid spread of a particular genetic element within a population of non-human organisms. Potential applications of GDTs include the control of insect vectors, invasive species ... pests. Whether, and if so, under what conditions, GDTs should be deployed is hotly debated. Although broad ... literature. Methods In this qualitative study, we interviewed GDT experts (n = 33) from different disciplines to identify ... their attitudes towards (1) the uncertainty related to GDTs; (2) the alternatives to which they should be ...
Tópico(s): Psychology of Moral and Emotional Judgment
2021 - BioMed Central | BMC Medical Ethics
Nienke de Graeff, Karin Jongsma, Jeantine E. Lunshof, Annelien L. Bredenoord,
Background Gene drive technologies (GDTs) bias the inheritance of a genetic element within a population of non-human organisms, promoting its progressive spread across this population. If successful, GDTs may be used to counter intractable problems such ... diseases. A key issue in the debate on GDTs relates to what governance is appropriate for these technologies. While governance mechanisms for GDTs are to a significant extent proposed and shaped ... explored in depth.Methods A total of 33 GDT experts from different professional disciplines were interviewed to ...
Tópico(s): Genetically Modified Organisms Research
2021 - Taylor & Francis | AJOB Empirical Bioethics
Springer Link
W. Brenton French, William Rothstein, Michael J. Scott,
... overload and utilization of goal-directed fluid therapy (GDT) to optimize intravascular volume, particularly in high-risk ... adequate, vasopressor use is an important component of GDT protocols. Vasopressors, especially norepinephrine, have historically been administered ... of norepinephrine.7–10 To encourage adoption of GDT principles, we will consider the existing evidence regarding ... s baseline blood pressure. A key concept in GDT is avoiding hypervolemia by administering fluids only when ... Vasopressor use is, thus, a critical component of GDT and is encouraged in the cases of hypotension ...
Tópico(s): Abdominal Surgery and Complications
2021 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Mariateresa Giglio, Gíanni Biancofiore, Alberto Corriero, Stefano Romagnoli, Luigi Tritapepe, Nicola Brienza, Filomena Puntillo,
Abstract Background Goal-directed therapy (GDT) aims to assure tissue perfusion, by optimizing doses and timing of fluids, inotropes, and vasopressors, through monitoring of cardiac output and ... basic hemodynamic parameters. Several meta-analyses confirm that GDT can reduce postoperative complications. However, all recent evidences ... meta-analysis is to investigate the effect of GDT on postoperative complications (defined as number of patients ... Data sources Randomized controlled trials (RCTs) on perioperative GDT in adult surgical patients were included. The primary ...
Tópico(s): Blood Pressure and Hypertension Studies
2021 - BioMed Central | Journal of Anesthesia Analgesia and Critical Care
John D. Bisognano, John E. Schneider, Shawn Davies, Robert L. Ohsfeldt, Elizabeth Galle, Ivana Stojanović, Thomas F. Deering, JoAnn Lindenfeld, Michael R. Zile,
... baroreflex activation therapy plus guideline directed therapy (BAT + GDT) compared to GDT alone for HF patients with reduced ejection fraction ... perspective over a 3-year period for BAT + GDT versus GDT alone. Expected costs were calculated by utilizing 6- ... Results At baseline the expected cost of BAT + GDT were $29,526 per patient more than GDT alone due to BAT device and implantation costs. ... per patient was $9521 less expensive for BAT + GDT versus GDT alone due to lower rates of significant HF ... procedures (LVADs and heart transplants) among the BAT + GDT group. Conclusions BAT + GDT treatment becomes less costly ...
Tópico(s): Cardiac Health and Mental Health
2021 - BioMed Central | BMC Cardiovascular Disorders
Nicolai Bang Foss, Henrik Kehlet,
... monitoring, the concept of perioperative goal-directed therapy (GDT) has gained prominence as an individualised approach to optimising flow parameters. The basis of GDT is optimisation of flow through measurement of stroke ... Scopus (222) Google Scholar Volume therapy based on GDT has been shown to improve perioperative outcomes when ... Anaesthesiol. 2018; 35: 1Google Scholar Different algorithms for GDT have been proposed, but the cornerstone has been ... 2263-2274Crossref PubMed Scopus (386) Google Scholar The GDT concept is flow based, even though most algorithms ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2019 - Elsevier BV | British Journal of Anaesthesia
Neil MacDonald, Rupert M. Pearse, Patrick Murray, Rosanna Inzitari, Peter Doran, John R. Prowle,
... major surgery. Peri-operative goal-directed haemodynamic therapy (GDT) may improve outcomes by reducing complications such as AKI.To determine if GDT was associated with a reduced incidence of postoperative ... a multicentre randomised controlled trial comparing peri-operative GDT to usual patient care.Four UK National Health ... after surgery was similar in the two groups [GDT 31/144 (21.5%) patients vs. usual patient ... urinary NGAL were also similar at 24 h (GDT 53.5 vs. usual patient care 44.1 ng ml; P = 0.38) and 72 h (GDT 45.1 vs. usual patient care 41.1 ...
Tópico(s): Abdominal Surgery and Complications
2019 - Lippincott Williams & Wilkins | European Journal of Anaesthesiology
Anders Granholm, Waleed Alhazzani, Morten Hylander Møller,
... Oxman A, eds. GRADE Handbook. Available from: https://gdt.gradepro.org/app/handbook/handbook.html (accessed 15 ... Oxman A, eds. GRADE Handbook. Available from: https://gdt.gradepro.org/app/handbook/handbook.html (accessed 15 ... Oxman A, eds. GRADE Handbook. Available from: https://gdt.gradepro.org/app/handbook/handbook.html (accessed 15 ... Oxman A, eds. GRADE Handbook. Available from: https://gdt.gradepro.org/app/handbook/handbook.html (accessed 15 ... Oxman A, eds. GRADE Handbook. Available from: https://gdt.gradepro.org/app/handbook/handbook.html (accessed 15 ...
Tópico(s): Meta-analysis and systematic reviews
2019 - Elsevier BV | British Journal of Anaesthesia
Bernd Saugel, Karim Kouz, Thomas Scheeren,
Perioperative goal-directed haemodynamic therapy (GDT) is a protocolised treatment strategy aimed at optimisation of global cardiovascular dynamics, including oxygen delivery to tissues and organ perfusion pressure. ... Text PDF PubMed Scopus (1367) Google Scholar perioperative GDT has been refined, further developed, and widely tested ... the past two decades. Numerous RCTs comparing perioperative GDT with standard of care have been performed in ... meta-analyses that provide substantial evidence that perioperative GDT can improve postoperative outcomes in patients having surgery. ...
Tópico(s): Blood Pressure and Hypertension Studies
2019 - Elsevier BV | British Journal of Anaesthesia
Antonio Messina, Corrado Pelaia, Andrea Bruni, Eugenio Garofalo, Eleonora Bonicolini, Federico Longhini, Erica Dellara, Laura Saderi, Stefano Romagnoli, Giovanni Sotgiu, Maurizio Cecconi, Paolo Navalesi,
... hemodynamic targets, the so-called Goal-Directed Therapy (GDT), or to correct hemodynamic instability (non-GDT).In this systematic review, we considered the FC components in studies adopting either GDT or non-GDT, to assess whether differences exist between the 2 ... SVV), in predicting fluid responsiveness.Thirty-five non-GDT and 33 GDT studies met inclusion criteria, including 5017 patients. In the vast majority of non-GDT and GDT studies, the FC consisted in the administration of ... 7% and 90.9%, respectively). In 29 non-GDT studies, the colloid infused was the 6% hydroxyethyl ...
Tópico(s): Blood Pressure and Hypertension Studies
2018 - Lippincott Williams & Wilkins | Anesthesia & Analgesia
Shahroz Khan, Muhammad Junaid Awan,
... a state-of-the-art generative design technique (GDT), called Space-filling-GDT (Sf-GDT), for the creation of innovative designs. The proposed Sf-GDT has the ability to create variant optimal design ... given computer-aided design (CAD) model. An effective GDT should generate design alternatives that cover the entire ... approach is developed and integrated into the Sf-GDT. One of the core contributions of this work lies in the ability of Sf-GDT to explore hybrid design spaces consisting of both ... called Jaya algorithm, is integrated into the Sf-GDT to generate optimal designs. Three different design parameterization ...
Tópico(s): Topology Optimization in Engineering
2018 - Elsevier BV | Advanced Engineering Informatics
... does the term ‘perioperative haemodynamic goal-directed therapy (GDT)’ actually mean? For which patients is this approach ... with the easiest part of the term perioperative ‘GDT’; ‘perioperative’. Does it mean to start before surgery ... surgical trauma and haemodynamic disturbances occur. However, with GDT becoming one part of multidisciplinary and multimodal treatment ... distribution to end organs, we can agree that GDT is about optimisation of stroke volume and (multiplied ... last 20 yr, and its use in perioperative GDT strategies has provided many answers in this regard. ...
Tópico(s): Ultrasound in Clinical Applications
2018 - Elsevier BV | British Journal of Anaesthesia
Daniela Gómez, Christopher Power, M. John Gill, Esther Fujiwara,
... was assessed via the Game of Dice Task (GDT). Sample characteristics were summarized by principal component analysis (PCA) prior to regression analyses predicting GDT performance.The NN group performed within the normative range of the GDT, but the HAND group was impaired in all GDT measures. Across all participants, GDT performance was predicted by a combination of psychiatric ... use as an important additional predictor of impaired GDT performance. Within the GDT-impaired HAND group only, past or present immunosuppression ...
Tópico(s): HIV/AIDS Research and Interventions
2017 - American Psychological Association | Neuropsychology
PoonamMalhotra Kapoor, Rohan Magoon, RajinderSingh Rawat, Yatin Mehta, Sameer Taneja, Radhika Ravi, MilindP Hote,
... circulation. The preliminary results of goal-directed therapy (GDT) for hemodynamic management of high-risk cardiac surgical ... the outcome benefits with the combined use of GDT with OPCAB as compared to the conventional hemodynamic ... randomly divided into two groups; the control and GDT groups. The GDT group included the monitoring and optimization of advanced ... Intensive Care Unit (ICU) and corrected according to GDT protocol. A total of 163 patients consented for ... Result: Seventy-five patients were assigned to the GDT group and 88 patients were in the control ...
Tópico(s): Ultrasound in Clinical Applications
2017 - Medknow | Annals of Cardiac Anaesthesia
Zongxiao He, Di Zhang, Alan E. Renton, Biao Li, Linhai Zhao, Gao T. Wang, Alison Goate, Richard Mayeux, Suzanne M. Leal,
... a RV extension of the generalized disequilibrium test (GDT) to analyze sequence data obtained from nuclear and extended families. The GDT utilizes genotype differences of all discordant relative pairs ... and the RV extension combines the single-variant GDT statistic over a genomic region of interest. The RV-GDT has increased power by efficiently incorporating information beyond ... simulated genetic data, we demonstrated that the RV-GDT method has well-controlled type I error rates, ... disease to illustrate the application of the RV-GDT. Given the capability of the RV-GDT to ...
Tópico(s): Genomics and Rare Diseases
2017 - Elsevier BV | The American Journal of Human Genetics
Shirajahammad M. Hunagund, Vani R. Desai, Delicia A. Barretto, Malatesh S. Pujar, Jagadish S. Kadadevarmath, Shyamkumar Vootla, Ashok H. Sidarai,
... report the synthesis of gadolinium doped titanium dioxide (GdT) nanoparticles (NPs) via hydrothermal method using a novel ... betel leaf. The physiochemical properties of green synthesized GdT NPs were characterized using various techniques. The results reveal that GdT NPs have attached with the biomolecules which were supporting evidence for the reduction and capping agents. GdT NPs have crystalline in nature and their estimated ... 5.45 nm by the Scherer's formula. GdT NPs consist of well-dispersed agglomerates of grains ...
Tópico(s): Advanced Nanomaterials in Catalysis
2017 - Elsevier BV | Journal of Photochemistry and Photobiology A Chemistry
Laurence Weinberg, Jonathan Banting, Leonid Churilov, Robert McLeod, Kimberly A. Fernandes, Ian Chao, Timothy Ho, Damian Ianno, Vivian Liang, Vijayaragavan Muralidharan, Christopher Christophi, Mehrdad Nikfarjam,
... effect of a surgery-specific goal-directed therapy (GDT) physiologic algorithm on complications and length of hospital ... with a surgery-specific cardiac output–guided algorithm (GDT group). We included 145 consecutive patients: 47 in the GDT group and 98 in the usual care group. Multivariable associations between GDT and lengths of stay and complications were investigated ... common and occurred at similar frequencies amongst the GDT and usual care groups: 64% versus 68% respectively, ... 70). There were fewer cardiorespiratory complications in the GDT group. Median (interquartile range) length of hospital stay ...
Tópico(s): Blood Pressure and Hypertension Studies
2017 - SAGE Publishing | Anaesthesia and Intensive Care
... that the use of perioperative goal-directed therapy (GDT) with uncalibrated pulse contour (uPC) techniques is associated ... 2008 and 2015, in which the intervention included GDT with uPC methods.1Michard F Giglio MT Brienza ... the haemodynamic goals that were used in the GDT protocols of these studies. In 16 of the 19 studies, the main haemodynamic goal of the GDT protocol was a continuous dynamic parameter, namely the ... meta-analysis, is that, as aptly said before, “GDT can be a vague term, meaning different things ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2017 - Elsevier BV | British Journal of Anaesthesia
Yasemin Irvin-Erickson, Nancy La Vigne, Ned Levine, Emily Tiry, Samuel Bieler,
Evaluate the sensitivity of Gunshot Detection Technology (GDT) relative to Calls for Service. Existing crime data sources have biases that do not present a complete picture of gun-related crime. GDT may offer a new metric for firearm crimes. However, few studies have assessed the accuracy of GDT and its relationship to other measures of violence. GDT and gun crime-related Calls for Service in ... time period dataset, we examined the sensitivity of GDT activations relative to gunshot-related calls for service. ...
Tópico(s): Traffic and Road Safety
2017 - Elsevier BV | Applied Geography
Sebastian Schmid, Barbara Kapfer, Markus Heim, Ralph Bogdanski, Aida Anetsberger, Manfred Blobner, Bettina Jungwirth,
... whether an algorithm-guided goal-directed haemodynamic therapy (GDT) can improve renal outcome compared to good standard ... assigned to one of two groups: in the GDT group, patients were treated with a GDT algorithm using transpulmonary thermodilution while standard care was ... 1-year mortality as secondary outcomes. Haemodynamics in GDT and control patients were compared calculating goal-achievement ... μmol/l (control) vs. 16 ± 42 μmol/l (GDT); mean difference (95 % confidence interval) 1.6 μmol/ ... to 13 μmol/l)) was comparable between the GDT and the control group. Postoperative complications and mortality ...
Tópico(s): Abdominal Surgery and Complications
2016 - BioMed Central | Critical Care
Chelsea M. Blankenship, Fawen Zhang, Robert W. Keith,
... speech perception performance. Measurement of gap detection thresholds (GDTs) is the most common measure currently used to assess temporal resolution. However, most GDT studies completed with CI participants used direct electrical ... is necessary to determine if the variance in GDTs assessed with clinical measures of temporal processing such ... A correlational study investigating the relationship between behavioral GDTs (assessed with the RGDT or the Expanded Randomized ... attenuated test booth. After measuring pure-tone thresholds, GDTs and speech perception performance were measured. The difference ...
Tópico(s): Hearing, Cochlea, Tinnitus, Genetics
2016 - Georg Thieme Verlag | Journal of the American Academy of Audiology
Camilo Correa‐Gallego, Kay See Tan, Vittoria Arslan‐Carlon, Mithat Gönen, Stephanie C. Denis, Liana Langdon‐Embry, Florence Grant, T. Peter Kingham, Ronald P. DeMatteo, Peter J. Allen, Michael I. D’Angelica, William R. Jarnagin, Mary Fischer,
... for liver resections remains undefined. Goal-directed therapy (GDT) embodies a number of physiologic strategies to achieve ... trial, patients undergoing liver resection were randomized to GDT using stroke volume variation as an end point ... one hundred and thirty-five patients were randomized (GDT: n = 69; standard perioperative resuscitation: n = 66). Median ... Metastatic disease comprised 81% of patients. Overall (35% GDT vs 36% standard perioperative resuscitation; p = 0.86) and grade 3 morbidity (28% GDT vs 18% standard perioperative resuscitation; p = 0.22) ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2015 - Lippincott Williams & Wilkins | Journal of the American College of Surgeons
Maurizio Cecconi, Andrew Rhodes,
... anesthesia and intensive care medicine, goal-directed therapy (GDT) refers to the use of fluids and/or ... Shoemaker et al.2 suggested that hemodynamic optimization (GDT) targeting the CO and DO2 levels observed in ... in a series of studies, investigators have tested GDT during and after surgery. The majority of these ... to endorse the use of esophageal Doppler for GDT in the perioperative care of high-risk surgical ... results of a multicenter randomized controlled trial on GDT (the Pulmonary Hypertension Screening, a Multidisciplinary Approach in ...
Tópico(s): Blood Pressure and Hypertension Studies
2014 - Lippincott Williams & Wilkins | Anesthesia & Analgesia