Processing α-glucosidase I (GluI) is a key member of the eukaryotic N-glycosylation processing pathway, selectively catalyzing the first glycoprotein trimming step in the endoplasmic reticulum. Inhibition of GluI activity impacts the infectivity of enveloped viruses; however, ... substrate Glc3Man9GlcNAc2. The first structural model of eukaryotic GluI is here presented at 2-Å resolution. Two ... characterized in this work, the active site of GluI was mapped. From these results, a model of ... formulated, which is most likely conserved in mammalian GluI. Processing α-glucosidase I (GluI) is a key ...
Tópico(s): Glycosylation and Glycoproteins Research
2013 - Elsevier BV | Journal of Biological Chemistry
Peter Setlow, Craig Gérard, Juris Ozols,
... The sequences surrounding the cleavage sites are -Tyr-Glui Ile-Ala-Ser-Glu-Phe-in the A protein, -Phe-Glui Ile-Ala-Ser-Glu-Phe-in the C protein, and -Thr-Glui Phe-Gly-Ser-Glu-Thr-, and -Thr-Glui Phe-Ala-Ser-Glu-Thr-in the B ...
Tópico(s): Machine Learning in Bioinformatics
1980 - Elsevier BV | Journal of Biological Chemistry
S.S. Karade, Evelyn J. Franco, Ana C. Rojas, Kaley C. Hanrahan, A. V. Kolesnikov, Wenbo Yu, Alexander D. MacKerell, Daniel C. Hill, David J. Weber, Ashley N. Brown, Anthony M. Treston, Roy A. Mariuzza,
... quality control (ERQC) enzyme α-glucosidase I (α-GluI) is an attractive target for developing broad-spectrum ... interact with all four subsites of the α-GluI active site. These inhibitors are derivatives of the ... DNJ) and valiolamine. Crystal structures of ER α-GluI bound to 25 1-DNJ and three valiolamine ... method to develop a model for predicting α-GluI inhibition. We screened the compounds against SARS-CoV- ...
Tópico(s): Bacteriophages and microbial interactions
2023 - American Chemical Society | Journal of Medicinal Chemistry
Arturo Cocco, Marjorie A. Hoy,
... Rose, Nang Phaya, Misi Luki, Manzano, Lady Finger, Glui Kai, and Ebun Musak) of leaf discs tested, ... could not be reared on potted banana trees (Glui Kai, Dwarf Green, and Nang Phaya varieties), but ...
Tópico(s): Forest Insect Ecology and Management
2009 - Florida Entomological Society | Florida Entomologist
... protective effect against the 20 mM glutamate-insult (GluI). The parameters affected were (control vs. GluI): glutathione (8.9 ± 0.8 vs. 2.5 ± ...
Tópico(s): Medicinal Plants and Bioactive Compounds
2014 - Elsevier BV | Personalized Medicine Universe
Yannick Gueguen, Patrick Chemardin, A. Arnaud, P. Galzy,
... was found to produce three intracellular β-glucosidases (GluI, II, and III). These enzymes were visualized by ... staining after separation by native polyacrylamide gel electrophoresis. GluI, which represents 95.5% of the total β- ...
Tópico(s): Polysaccharides and Plant Cell Walls
1995 - Elsevier BV | Enzyme and Microbial Technology
Chi-Huang Chang, Yeh Chen, Xin-Xiung Yew, Hua-Xin Chen, Jia-Xuan Kim, Chun-Chao Chang, Chiung Chi Peng, Robert Y. Peng,
... protective effect against the 20 mM glutamate-insult (GluI). The parameters affected were (control vs. GluI): glutathione (8.9 ± 0.8 vs. 2.5 ± ...
Tópico(s): Polysaccharides and Plant Cell Walls
2015 - Elsevier BV | LWT
J. L. J. Gaillard, A Schaberg,
... was coupled to an amphoteric polypeptide, poly[Lys-(Glui-dl-Alam)] (EAK), which was selected for conjugation ...
Tópico(s): Advanced biosensing and bioanalysis techniques
1964 - Elsevier BV | Experimental Cell Research
H. Bryan Brewer, Robert J. Schlueter, J. P. Aldred,
... 32 amino acids including Argl, Hisr, Thrz, Ser4, GluI, ProB, Glys, Alan Vain MetI, Asm, AspI, Lysl, ...
Tópico(s): Morinda citrifolia extract uses
1970 - Elsevier BV | Journal of Biological Chemistry
Thomas Schulte, Gene A. Scarborough,
... transported primarily by a glucose-facilitated diffusion system (GluI). When it is grown in a medium with ...
Tópico(s): Photosynthetic Processes and Mechanisms
1975 - American Society for Microbiology | Journal of Bacteriology
Kevin Montgomery, Cynthia Bruyns, Joel Brown, Stephen Sorkin, Frédéric Mazzella, Guillaume Thonier, Arnaud Tellier, Benjamin Lerman, Anil Menon,
... written in C++ with OpenGL for graphics; GLUT, GLUI, and MUI for user interface; and supports parallel ...
Tópico(s): 3D Shape Modeling and Analysis
2002 - IOS Press | Studies in health technology and informatics
György Kóczán, Asoke C. Ghose, Ananda Mookerjee, Ferenc Hudecz,
... dl-Alam-Leui)] (ALK)), or amphoteric (poly[Lys(Glui-dl-Alam)] (EAK)) synthetic branched polypeptides containing poly[ ...
Tópico(s): Quinazolinone synthesis and applications
2002 - American Chemical Society | Bioconjugate Chemistry
Galina V Tarasova, Tatiana N. Nayakshina, S. Kh. Degtyarev,
... endonucleases have been described. Enzymes BisI, BlsI, and GluI are isoschizomers and hydrolyze the DNA sequence 5'- ...
Tópico(s): Genomics and Chromatin Dynamics
2008 - Springer Science+Business Media | BMC Molecular Biology
Eunice Murage, Jonathan C. Schroeder, Martin Beinborn, Jung‐Mo Ahn,
... synthesized by introducing lactam bridges between Lysi and Glui+4 to form α-helices at various positions. ...
Tópico(s): Receptor Mechanisms and Signaling
2008 - Elsevier BV | Bioorganic & Medicinal Chemistry
Jean Rivier, József Gulyás, Koichi S. Kunitake, Michael R. DiGruccio, Jeffrey P. Cantle, Marilyn H. Perrin, Cindy Donaldson, Joan Vaughan, Mulugeta Million, Guillaume Gourcerol, David W. Adelson, Catherine Rivier, Yvette Taché, Wylie Vale,
... an i−(i+3) bridge consisting of the Glui-Xaa-Xbb-Lysi+3 scaffold, where residues i = ...
Tópico(s): Adrenal Hormones and Disorders
2007 - American Chemical Society | Journal of Medicinal Chemistry
Produção Nacional
Revisado por pares
Amanda Reges de Sena, Gildomar Lima Valasques, Aristóteles Goés‐Neto, Alex Gutterres Taranto, Carlos Priminho Pirovani, Júlio Cézar M. Cascardo, Russolina B. Zingali, Marcos Almeida Bezerra, Sandra Aparecida de Assis,
... days, respectively. The results revealed three different isoforms (GLUI, GLUII and GLUIII) with purification factors of 4. ...
Tópico(s): Enzyme Production and Characterization
2011 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Binhai Ren, Bronwyn A. O’Brien, M Byrne, Edwin Ch'ng, Prudence N. Gatt, M. A. Swan, Najah T. Nassif, Ming Wei, Rik Gijsbers, Zeger Debyser, Ann M. Simpson,
... hepatic markers, C/EBP‐β , G6PC , AAT and GLUI was down‐regulated in INS‐FUR‐treated livers. ...
Tópico(s): Endoplasmic Reticulum Stress and Disease
2013 - Wiley | The Journal of Gene Medicine
Laura Cervini, Cynthia J. Donaldson, Steven C. Koerber, Wylie Vale, Jean Rivier,
... scan of cyclo(i,i+3)[MeTyr1,Ala15,Glui,Lys(i+3),Nle27]-hGHRH(1−29)-NH2 ...
Tópico(s): Click Chemistry and Applications
1998 - American Chemical Society | Journal of Medicinal Chemistry
Katalin A. Wilkinson, H. M. Vordermeier, Robert J. Wilkinson, Juraj Iványi, Ferenc Hudecz,
... carrier, an amphoteric branched chain polypeptide, poly[Lys-(Glui-DL-Alam)] (EAK) with poly(L-lysine) backbone ...
Tópico(s): Mycobacterium research and diagnosis
1998 - American Chemical Society | Bioconjugate Chemistry
Jean Rivier, Sabine L. Lahrichi, József Gulyás, Judit Érchegyi, Steven C. Koerber, A. Grey Craig, Anne Corrigan, Catherine Rivier, Wylie Vale,
... i+3)] and a cyclo(i,i+3)[Glui−Lys(i+3)] bridge on the in vitro ...
Tópico(s): Hormonal Regulation and Hypertension
1998 - American Chemical Society | Journal of Medicinal Chemistry
Jing Chen, Qi Huang, Zhuobin He, Guoying Tan, Yuan‐Sheng Zou, Juying Xie, Zhengming Qian,
... 5), which had been reported as an α-GLUI in PCR in the literature. Finally, molecular docking ...
Tópico(s): Phytochemicals and Antioxidant Activities
2023 - Multidisciplinary Digital Publishing Institute | Molecules
Rosalee Wolfe, John Lowther, Ching-Kuang Shene,
... of publicly available tools (e.g., GLUT and GLUI) and other tools developed by the instructor of ...
Tópico(s): 3D Modeling in Geospatial Applications
2000 - ACM SIGGRAPH | ACM SIGGRAPH Computer Graphics
Nancy Martín, Murray Rabinowitz,
... tRNA eluting first from the RPC-5 column (GluI-tRNA) respond to oligonucleotides including the glutamic acid ...
Tópico(s): RNA Research and Splicing
1984 - Academic Press | Methods in enzymology on CD-ROM/Methods in enzymology
Filia Stephanie, Ahmad Husein Alkaff, Usman Sumo Friend Tambunan,
... four DENV serotypes. Targeting host protein alpha-glucosidase (GluI), which responsible for one particular step of the ... peptide that can act as an inhibitor towards GluI was screened through several in silico process and ... molecular docking simulation with the 3D structure of GluI. The peptide was chosen as the ligands as ... ID: 4J5T was chosen to represent the human GluI, and 55,467 peptide compounds were retrieved from ... for a peptide with a suitable feature as GluI inhibitor. After the virtual screening, about 1,792 ...
Tópico(s): Insect Resistance and Genetics
2020 - American Institute of Physics | AIP conference proceedings
S.S. Karade, A. V. Kolesnikov, Anthony M. Treston, Roy A. Mariuzza,
... on the ERQC enzyme α-glucosidase I (α-GluI) has been hampered by difficulties in obtaining crystal ... as a robust surrogate for mammalian ER α-GluI and a platform for inhibitor design. Previously annotated ... its crystal structure to that of mammalian α-GluI, by demonstrating enzymatic activity on the unusual α- ... showing that well-known inhibitors of mammalian α-GluI (1-DNJ, UV-4, UV-5) also inhibit Ct α-GluI. Crystal structures of Ct α-GluI in complex with three such inhibitors (UV-4, ... the catalytic mechanism. Identification of ER Ct α-GluI as a surrogate for mammalian α-GluI will ...
Tópico(s): Glycosylation and Glycoproteins Research
2022 - American Chemical Society | Biochemistry
... bp (base pairs) DNA fragmen of glucoamylase gene (GLUI) of E. fibuligera ITB. R. cc. 64 has ... of 1784 bp DNA fragmen of glucoamylase gene (GLUI) by the restriction enzyme above. The second was to know homologyst the glucoamylase gene (GLUI) E. fibuligera ITB. R. cc. 64 and the glucoamylase gene (GLUI) Saccharomycopsis fibuligera HUT 7212 (pSf GLUI). The result of amplification glucoamylase gene (GLUI) indicated that 1784 bp DNA fragmen on GLUI locus has succesfully isolated and gave the same size with the positive control pSf GLUI. Analysis of those DNA fragmen by StuI, Eco ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2005 - Indonesian Biological Society | Berkala Penelitian Hayati
V. Dell’Orto, Elisabetta Salimei, V. Bontempo, Francesco Fantuz,
... élevé qu'à t o , de 30% environ, (GLUI, = 3,0 ; 3,2 ; 3,0 ; 3,2 ...
Tópico(s): Xenotransplantation and immune response
1994 - EDP Sciences | Annales de Zootechnie