Srikumar Sen, Boxing Correspondent, Frances Gibb, Legal Affairs Correspondent, Christopher Savage, J. Lipman, Nicholas Wood, Political Correspondent, Anatol Lieven, Catherine Bennett, Richard Thomson Banking Correspondent, Maurice Sutton Director, Elizabeth Douglas, Andrew Longmore, Richard Thomson, Mark Souster, Ronald Faux, Cliff Feltham, Douglas Broom, Education Reporter, Michael Stevenson, Philip Howard, John Bell, City Editor, Hilary Finch, Jeremy Kingston, James Bone, Richard Evans, Media Editor, Richard Streeton, Richard Eaton, Stuart Jones Football Correspondent, Colin Narbrough, Gerald Davies, J. Sykes, Howard Foster, Stuart Jones, Mohsin Ali, Peter Ball, Jamie Dettmer, Irish Affairs Correspondent, Louise Taylor, Lawrence Lever, Andrew Billen Arts Correspondent, Peter Waymark, Martin Cropper, Rosemary Unsworth, Christopher Bland, Martin Lipson, Marcus Williams, David Hands, Charles Bremner, Richard Thomson, Banking Correspondent, Mary Collier, Humphrey Hawksley, Wolfgang M?nchau, Harvey Elliott, Air Correspondent, Steven Downes, Javed Akhtar, David Miller, (Michael Phillips), Michael Beament, Peter Davalle, Emma Wilkins, Raymond Keene, Chess Correspondent, Craig Brown, Paul Griffiths, Steve Acteson, Andrew McEwen, Diplomatic Correspondent, Phil McLennan, Colin Horspole, Mark Herbert, Richard Owen, John Wilton, Barry Pickthall, Polwarth, Daniel Ward Motoring Correspondent, Geoffrey Foster, Brian Beel, Derek Harris, Industrial Editor, Keith MacKlin, Deyan Sudjic, Martin Fletcher and Michael Evans, Christopher Thomas, Christopher Thomas Montreal, John Goodbody, Andrew Morgan and Mark Ellis, Carol Ferguson, George Hill, Sam Kiley, Higher Education Reporter, Ivor Stanbrook, Graham Searjeant, Financial Editor, Paul Newman, Sarah Jane Checkland Art Market Correspondent, Michael Hornsby, Philip Webster, David Sinclair, Stephen Pettitt, Ian a Jack, Martin Waller, John Young Agriculture Correspondent, Bailey Morris, David Tytler, Education Editor, Rodney Lord, Economics Editor, Derek Harris Industrial Editor, Andrew McEwen Diplomatic Correspondent, Richard Ford, Political Correspondent, Pearce Wright, Science Editor, Craig Seton, Peter Mulligan and Sarah Jane, Tim Jones, Employment Affairs Correspondent, David Hands, Rugby Correspondent, Colin McQuillan, Roger Greene, Robert Kilroy-Silk, Richard Battley,
... new Colt with style Roadtest Mitsubishi Colt 1500 GLX Cornering without a screech Hot hatchbacks are frowned ...
1988 - Gale Group | TDA
Venkatagiri Krishnamurthy, Isabella Paredes Spir, Kevin Mammino, Joe R. Nocera, Keith McGregor, Bruce Crosson, Lisa C. Krishnamurthy,
... gamma-aminobutyric acid, GABA, and glutamate-glutamine complex, Glx) are closely linked to oxidative metabolism. Within the ... older cognitively intact participants to collect GABA and Glx using magnetic resonance spectroscopy (MRS), CBF using pseudo- ... behavioral assessments. We observed expected differences in GABA+, Glx, and CBF between younger and older participants in ... a frontal domain-general region. When GABA+ and Glx were related to CBF via multiple linear regression, Glx was identified as the main contributor to the ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2022 - Frontiers Media | Frontiers in Psychiatry
Linford Christie, Julia Llewellyn Smith, Roger Cook, Charles Hall, James Landale and Nicholas Wood, Gillian Bowditch Scotland Correspondent, Christopher Thomas, South Asia Correspondent, Rob Hughes, Jeremy Laurance, Richard Ford, Home Correspondent, Robert Vincent, Magnus Linklater, Andrew Longmore, Stewart Tendler and Dominic Kennedy, Richard Thomson, Shaun M. Silson, Martin Mears, Judith Chernaik, Alan Leaman, Director, Philip Howard, Michael Evans, Defence Correspondent, and James Landale, Stephen L. Bragg, Richard Duce, and Bill Frost, Michael Binyon, Jeremy Kingston, Jacob Starkman, Olli Kivinen, Carl Mortished, Victoria Wood, R. J. Simmons, Kenneth Baker, Robin T. Greenwood, Alexei Sayle, Geoff Brown, Robert Sheehan, Bridge Correspondent, Robert Miller, Martin Fletcher, Harry Holt, Stuart Jones, John Hopkins, Golf Correspondent, Richard Beeston and our Foreign Staff, Peter Ball, Lucy Shiels, Michael Knipe, Raymond Keene Chess Correspondent, Thomas De Waal, Dalya Alberge Arts Correspondent, Martin Barrow, Libby Purves, Alan Hamilton, Michael Clark, John Young, Quentin Letts, Richard Arthur, Leader, Sarah Bagnall, Nigella Lawson, Edward Gorman, Neil MacFarlane, Patricia Tehan, Banking Correspondent, William J. Warnes, Russell Kempson, Helen Bamber, Director, George Sharratt, Alfred Doll-Steinberg, Richard Cork, Sacha Craddock, Philip Bassett, Marcia Hill, David Miller, Gabriella Gamini, Richard Hornby, Professor James Drife, Jon Ashworth and Melvyn Marckus, Barry Millington, Raymond Keene, Christine Buckley, Tom Stoppard, Paul Wilkinson, P. H. S, Eric Reguly, Miles Hudson, Roger Boyes, Gina King, Kate Alderson, John Allison, Christopher Thomas, John Goodbody, Peregrine Hodson, Mel Webb, Srikumar Sen Boxing Correspondent, Rodney Hobson and Iola Smith, Matthew Parris, Clare Francis, Christopher Walker, Middle East Correspondent, John Shaw, Scrivenor, Richard Ford and Philip Webster, Peter Riddell, Ben MacIntyre, Alan Jenkins, Nadine Meisner, David Sinclair, Philip Pangalos, Michael Binyon, Diplomatic Editor, Johan Rapp, Michael Horsnell, Tony Robinson, Dr Thomas Stuttaford, Jill Sherman, Political Correspondent, Marianne Curphey, Stockton, Michael Evans Defence Correspondent, David Powell, Frances Gibb, Julian, Arthur Leathley, Vince Wright, Andrew Finkel, Matthew Bond, David Hands, Rugby Correspondent, Christopher Irvine,
... of samba on Teesside Index Win a Galaxy GLX Howarth clashes with Portillo Hurd's £250,000 ...
1995 - Gale Group | TDA
Matthew D. Ramirez, Alexi C. Besser, Seth D. Newsome, Kelton W. McMahon,
... TP CSIA estimates to uncertainty in mean β Glx‐Phe values and Glx‐Phe trophic discrimination factors (TDF Glx‐Phe ). We show that variation in β Glx‐Phe values is two times greater than previously ... vascular plants, tissue type secondarily contributed to β Glx‐Phe value variability, but we found no clear ... C 3 , C 4 and CAM plant β Glx‐Phe values. Notably, we found that vascular plant β Glx‐Lys values (+2.5 ± 1.6‰) are considerably less variable than β Glx‐Phe values, making Lys a useful AA tracer ... are highly sensitive to changes in both β Glx‐Phe and TDF Glx‐Phe values but that ...
Tópico(s): Microbial Community Ecology and Physiology
2021 - Wiley | Methods in Ecology and Evolution
Jonathan Northcroft, John Dugdale, Philip Marsden, Robert Tchenquiz, Matthew Wall, Barbara Hall, Nigel Botherway, Margie McGregor, Jeff Dawson, Kim Howells, Anthony Everitt, Ian Fraser, Tracey Cox, John Fusco, John White, David Brown, David Canter, Matthew Sturgis, Henry Cooper's, Helen Davies, Rob Hughes, Sir David Attenborough, John Peter, Pam Barrett, Martin James, Mark Hodgkinson, V S, Professor Gideon Garter, Belinda Jones, Amanda Ursell, Jim Munro football editor, Andrew Longmore, Sharon Walker, C H J, J D, Susan d'Arcy, Nick Rufford, Gareth Walsh, Frank Whitford, Chris Kline, Ivo Tennant, Nicolette Jones, Ferdinand Mount, David Gower, Kathryn Cooper, Sam Gilpin, David Smith, John Nutton, Tim Richards, Dave Sones, Peter Sharkey, Steven Poole, Alastair McCall, Neil Wormald, Richard Green, E P, Andrew Sullivan, Clive Davis, Stephen Grey, K R, Tom Evans, C D, Tony Allen-Mills, Simon Wilde, Nick Metcalf, David Sharp, Philip Bellamy, Tom Walker, Anthony Sattin, Alex Clarke, Robert Winnett, Kitty Aldridge, Irwin Stelzer, Adrian Furnham, Robert Hewison, Peter Wilson, John Aiziewood, Sonia Follows, Rosie Millard, Lawrence Dallaglio, David Dougill, Rachel Dobson, Bill Dunn, Philip Kerr, John Page, David Hewson, Alistair Weaver, Cally Law, David Bond, Jonathon Carr-Brown, Hugh Canning, Joe Swift, Nils Pratley, Kathy Harvey, Jeremy Clarkson, Stewart Lee, Edward Porter, Victoria Segal, Louise Taylor, S L, Patricia Nicol, Hilary Clarke, John O'Donnell, Liz Edwards, George Perry, Philip O'Connor, James Delingpole, Adam Nathan, Shelley von Strunckel, Richard Johnson, David S Ware Quartet, Peter Parker, Roger Eglin, Tom Conran, Dominique Coughlin, Steve Waugh, Frances Spalding, Zoe Thomas, Chris Woodhead, Sarah Smith, Lucinda Kemeny, Jasper Gerard, Paul Driver, Boris Schapiro, John Humphrys, Nicholas Hellen, Ian Hawkey, George Melly, Alex Clark, Christopher Morgan, David Leppard, B C, Mark Ludlow, Lisa Grainger, Michael Lynagh, Mark Edwards, Susan Clark, Matthew Sheahan, Eben Black Chief Political Correspondent, Lucy Wakefield, Mary Land, Anthony Perrottet, Lois Rogers, Sean Newsom, David Budworh, Pat O'Connor, Raymond Keene, Robert Winnett Affairs Correspondent, Lisa Ratliffe, Gareth Huw Davies, Douglas Alexander, Stanley Stewart, Cosmo Landesman, Zoe Brennan, Marie Colvin, Gavin Conway, Rachel Holloway, S B, Stephen Jones, Dominic O'Connell, Richard Evans, Uzi Mahnaimi, Nick Cain, Gavin Trewartha, Louise Armitstead, Frankel, Melinda Stevens, Benjys, H Stanley, Caroline Donald, M J, Rob Ryan, Fiona Terry, David Walsh, Peter Coad Director, John Stern, Colin McDowell, Chris Salewicz, Stephen Armstrong, John Elliott, Clare Nolan, Christopher Goodwin, Richard Woods, Roland White, Jack Whittaker, Dina Catchpole, Maurice Chittenden, Jue Lovejoy, Alex Fortune, Charles Lloyd, Richard Rae, Mark Franchetti, Julie Burchill, Craig Lord, Ray Hutton, David Hoppit, Tony Brook, Jonathan Leake, Martin Brayne, Michael Sheridan, D J Taylor, John Harlow, Philip Beresford, Godfrey Smith, Jane Lush, Barry Collins, Dipesh Gadher, John Waples, Marc Zakian, A A Gill, Martin Wright Vice-Chair, Joe Docherty, Matthew Campbell, Brian Glanville, Louise Johncox, Enda Leahy, Iain Milligan, Natalle Graham, Kirsty Lang, Tom Robbins, John Carey, Stella Rimington, Claudia Croft, Jason Mellor, Jonathan Calvert, Patricia Williamson, John Spurling, Rw Johnson, R H, Lindsay Duguild, Sally Kinnes, Naomi Caine, Liam Clarke, David Wickers, Nigel Powell, Caroline Turriff, Brian Doogan, Minette Marrin, Mark Hodson, Graham Norwood, Joe Lovejoy, Jonathan Futrell, Rupert Steiner, David Budworth, Hugh Pearman, D Marsh, Dan Cairns, Paul Stephen Lubicz, Pete Oliver, Simon Sebag Montefiore, David Grylls, Rob Hunter, David Smith Economics Editor, Conal Gregory, Sarah Baxter, Peter Roebuck, Joanna Simon, Matthew Goodman, India Knight, Steve Grant, Kingston Smith, Barry Newcombe, Richard Pym chief executive of Alliance & Leicester, Dominic Rushe, Richard Lewis, Sian Griffiths, Mansieur Mangetout,
... Classified Advertising Items Used Buy: Mondeo 1.8 Glx 5-door Jason Dawe Second Opinion The Sunday ...
2002 - Gale Group | Sunday Times HA GDA
Matthew S. Milak, Rain Rashid, Zhengchao Dong, Lawrence S. Kegeles, Michael F. Grunebaum, R. Todd Ogden, Xuejing Lin, Stephanie Mulhern, Raymond F. Suckow, Thomas B. Cooper, John G. Keilp, Xiangling Mao, Dikoma C. Shungu, J. John Mann,
... whether ketamine dose and brain glutamate and glutamine (Glx) and γ-aminobutyric acid (GABA) level responses to ... spectroscopy scan that measured ventro-medial prefrontal cortex Glx and GABA levels in 13-minute data frames. ... 0.007 to 0.133]). The lower the Glx response, the better the antidepressant response ( t 33 = − ... to −1.50]). Although GABA levels correlated with Glx ( t 33 = 8.117; P < .001; slope estimate, ... with antidepressant effect. When both ketamine dose and Glx response were included in a mediation analysis model, ...
Tópico(s): Advanced MRI Techniques and Applications
2020 - American Medical Association | JAMA Network Open
Sergeant David Bell, Peter Green, Sally Brock, V S, J C, Jonathan Miller, Jim Munro football editor, Mark Leatham, Ashia Hansen, Gareth Barry, Gareth Walsh, David Broadbent, Ferdinand Mount, David O'Leary, Neil Wormald, Ph B, Kathy Brewis, Joseph Dunn, Martin James, Anne Dawson, Rosie Millard, Stephen Balton, Phil Baty, Tony Marcus, Damon Hill, David Hewson, Clare McVey, Hugh Canning, S L, Sarah Dempster, James Brooks, Kevin Jackson, George Boateng, Frank Kermode, Paul Bailey, Geoff Fletcher, Jonathan Leake Enivironment Editor, Sarah Smith, John Humphrys, Danny Scott, Mark Ludlow, Alicia Wyllie, Sarah Gracie, Shawn Levy, Danny O'Brien, Justin Sneyd, Frances Jeater, C O, Robbie Hudson, Kenneth Cranham, Mason Zimbler, Philip Crebbin, Uzi Mahnaimi, Peta Bee, Jeremy Scott, Kate Rew, D J Wathen, John Elliott, Maurice Chittenden, Richard Brooks Arts Editor, Sophie Kirkham, Simon Cole Chief Superintendent, Raui Zidane, Campbell Scott, John Carey, Tania Unsworth, Arthur Daley, Imre Karacs, Sean O'brien, Liam Clarke, Raui, Simon Buckland, Lord Brougham, Sophie Ratner, James Knight, Graham Norwood, Robert Edric, A Bowie, Ben Rooney, Ashley Cole, Sarah Baxter, Ed Hughes, Vanessa Wilde, Jason Dawe, Jonathan Northcroft, George Derbyshire, Matthew Wall, Tim Pears, N J, Colin Brennan, Kevin Rushby, Andrew Longmore, George Canning, Jamie Carragher, Caroline Brannigan, Asne Seierstad, Richard Green, E P, Andrew Sullivan, Clive Davis, Monsiour Mangetout, Ricardo, T E, Sly Bailey, John Waples Deputy Business Editor, Finola Inger, M Surrey, Alasdair Reid, David Aldhouse, Liam Burton, Victoria Segal, Edward Porter, Marina Warner, Howard Clark, Anthony Peregrine, Irain Donnelly, Eben Black, Dave Pollard, David Eimer, Patrick Maxwell, Shelley von Strunckel, Brendan Bourne, Mike Laws, Professor Gideon Gorter, Paul Donovan, Janine Maunders, Frank Lampard, Louis Saha, Bob Woodward, Zoe Thomas, Hugh McIlvanney, Sarah Pask, Garth Pearce, Richard Brooks, Nick Posford, Richard Sambrook, B C, David Leppard, Jane Herbert, Stephen Amidon, Eben Black Chief Political Correspondent, Keith Richard, Alan Combes, Katrina Manson, Diana Wright, Christopher Smallwood, S B, Barry Flatman, Richard Evans, Natalie Graham, Dr Donald MacKenzie, Melvyn Bragg, S D, Keith Wheatley, S P, Mandy Francis, Matt Murray, Stephen Armstrong, Bethan Cole, Russell Bennett, Kieron Dyer, George Smith, Ray Hutton, Sir Nicholas Grimshaw, M E, Taher Elgalaid, Margaret Walters, Jonathan Prior, Ashesh Kumar Datta, Oak Hill, Alan Smith, A A Gill, Brian Glanville, Antonia Fraser, R H, Nigel Powell, Roger Dobson, Brian Doogan, Jonathan Futrell, Tony Perrottet, Richard Lewis, John Dugdale, Barbara Hall, Jeffrey Box, Jon Swain, Rob Hughes, Vijay Vaghela, J D, Virginie Luc, Niels J Bjergstrom, Ivo Tennant, David Gower, Matt Wolf, Shaka Hislop, C D, Danny Tiatto, Mick Jagger, D C, John O'Brien, Tom Walker, Merryn Somerset Webb, Charlie Watts, Lord Harris, Anthony Phillips, H C, Jean Hill, William Dalrymple, Stewart Lee, Alan Brownjohn, Patricia Nicol, John O'Donnell, Bob Dylan, Mrs P A C, Gene Robinson, Tom Conran, Natasha Frasar, Vincent Crump, James Mottram, Chris Woodhead, Alex Clark, Ed Smith, Mark Edwards, Rachel Bridge, Susan Clark, Chris Marsden, Jonathan Carr-Brown Health Correspondent, Sean Newsom, Felicity Squier, Raymond Keene, Stanley Stewart, Marie Colvin, Kipper Williams, Stephen Jones, Louise Armitstead, Anthony Gilberthorpe, Robbie Keane, Trevor Lewis, R W Johnson, Sir Edward Pickering, Roland White, Susan Bell Dax, Jeffrey Bell, Martin Styler, Kevin Pratt, Mark Franchetti, Stan Lazaridis, Michael Sheridan, Ian Edwards, Barry Collins, John Waples, Jeremy Hart, J M, Lion Clarke, Stephen Pettitt, Maria McErlane, Justin Sparks, Andrew Frankel, Joe Lovejoy, Cath Stobbart, Dan Cairns, David Grylls, Emma Fielding, A Caslin, Karen Robinson, Steven Shukor, P B, Michael Barrymore, Arthur Smith, Catherine Hayward, Tracey Cox, Fred Redwood, Harvey Nichols, Alain de Botton, Philip Norman, Tessa Mayes, Helen Davies, James Moore, Christopher Somerville, Patrick Vieira, David Bailey, Frank Whitford, David Boyle, Kathryn Cooper, Leonard Stern, P D, Maciej Pomian-Srzednicki, John O'Byrne, David Unsworth, K R, Andrew Porter, Tony Allen-Mills, Simon Wilde, Robert Winnett, Mike Russell, Irwin Stelzer, Robert Hewison, Peter Wilson, David Harding-Price, David Dougill, Rob Maul, Jonathon Carr-Brown, Margarette Driscoll, Geraldine Hackett Education Correspondent, David Cairns, Brad Friedel, Liz Edwards, Lydia Slater, Paula Robinson, Monica Waters, Harry Redknapp, Lucinda Kemeny, Jasper Gerard, Paul Driver, Vlada Radimirovic, Paul Durman, Jonathon Carr-Brown Health Correspondent, Mick Dennis, Matt Elliott, A Raine, Edward, Dean Koontz, C L, John Crickett, Marco Pierre White, Douglas Alexander, Cosmo Landesman, Jason Euell, E Bergin, Dominic O'Connell, Andrew Holgate, Chris Griffiths, Muriel Haseltine, M J, Caroline Donald, Colin McDowell, Elizabeth Flint, Ron Clarke, Shane Watson, Neil MacGregor Director, Jonathan Clayton, Christopher Gibbs, Kevin Nolan, Jonathan Leake, D J Taylor, Clare Francis, John Harlow, Christopher Ricks, Claudia Croft, Sally Kinnes, Emma Richards, Naomi Caine, Frank Carpenter, David Wickers, Lord Palmerston, Minette Marrin, George Edwards, Rupert Steiner, Paul Stephen Lubicz, Pete Oliver, John Vigar, Joanna Simon, India Knight, Kingston Smith, Edgar Davids,
... Second Opinion The Sunday Times Values Peugeot 206 GLX 2.0 HDi 5dr (with air-conditioning) This ...
2003 - Gale Group | Sunday Times HA GDA
Joshua T. Kantrowitz, Matthew S. Milak, Xiangling Mao, Dikoma C. Shungu, J. John Mann,
... acute increase in GABA and glutamate plus glutamine (Glx) as an early event in antidepressant action. Using ... produced rapid, transient elevations (approximately 40%) of both Glx and GABA levels in the medial prefrontal cortex ( ... glycine site partial agonist, on brain GABA and Glx in healthy subjects. Compared with ketamine, d-cycloserine ... scans for up to 90 minutes to measure Glx and GABA levels. Areas under the curve computed ... trapezoidal rule yielded large effect sizes for both Glx (69%, SD=48%, d=1.44) and GABA ( ...
Tópico(s): Neuroscience and Neuropharmacology Research
2016 - American Psychiatric Association | American Journal of Psychiatry
... Shary Pte. Miler Pte. Weatherspoor Sgt. Maj. Young Glx. Sgt. Mackey L. Opl. Murrieum Sgt. Adans Pte. ...
0000 - Gale Group | NCCO Photography
Richard J. Maddock, Michael H. Buonocore, Amber R. Miller, Jong H. Yoon, Steffan K. Soosman, April M. Unruh,
... changes in both lactate and glutamate plus glutamine (glx) in PD. Methods Twenty-one PD patients (13 ... editing sequence was used to measure lactate and glx changes in visual cortex induced by visual stimulation. ... differ from each other. Activity-dependent changes in glx were significantly smaller in PD patients than in healthy volunteers. The temporal correlation between lactate and glx changes was significantly stronger in control subjects than in PD patients. Conclusions The novel demonstration that glx responses are diminished and temporally decoupled from lactate ...
Tópico(s): Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
2013 - Elsevier BV | Biological Psychiatry
Jeffrey R. Strawn, Nick C. Patel, Wen‐Jang Chu, J. H. Lee, Caleb M. Adler, Mi Jung Kim, Holly Bryan, David C. Alfieri, Jeffrey A. Welge, Thomas J. Blom, Jayasree J. Nandagopal, Stephen M. Strakowski, Melissa P. DelBello,
... same time points. Glutamate (Glu) and glutamate+glutamine (Glx) concentrations were measured in three voxels: anterior cingulate ... healthy subjects. Within the bipolar subjects, Glu and Glx concentrations at baseline and each time point were ... Results At baseline, no differences in Glu or Glx concentrations between bipolar and healthy subjects were observed. ... the ACC, and change over time effects for Glx were noted in the ACC in patients with ... not in HC. Remitters had significantly lower baseline Glx concentrations in LVLPFC, and in remitters the change ...
Tópico(s): Electroconvulsive Therapy Studies
2012 - Elsevier BV | Journal of the American Academy of Child & Adolescent Psychiatry
Ronald A. Yeo, Steven W. Gangestad, Charles Gasparovic, Jingyu Liu, Vince D. Calhoun, Robert J. Thoma, Andrew R. Mayer, Ravi Kalyanam, Kent E. Hutchison,
... N-acetylaspartate (NAA), creatine-phosphocreatine (Cre), glutamate/glutamine (Glx), myoinositol (mI), and phosphorylcholine-glycerol phosphorylcholine (Cho). Genetic ... our sample) predicted lower NAA, Cre, mI, and Glx. More total rare deletions also predicted lower NAA, Cre, and Glx. Principal components analyses of the five neurometabolites identified two correlated components, the first comprised of NAA, Glx, and Cre, and the second comprised of Cho, ... disorders. The greater effect of CVNs on NAA, Glx, and Cre may reflect a greater sensitivity to ...
Tópico(s): Genetic Associations and Epidemiology
2011 - Elsevier BV | Biological Psychiatry
... review the biological significance of glutamate, glutamine, and Glx (composed mainly of glutamate and glutamine). Next, we ... Here, we find a highly consistent pattern of Glx-level reductions in major depressive disorder and elevations ... review the biological significance of glutamate, glutamine, and Glx (composed mainly of glutamate and glutamine). Next, we ... Here, we find a highly consistent pattern of Glx-level reductions in major depressive disorder and elevations ... amino butyric acid (GABA), and other metabolites (termed Glx) in the central nervous system. In the past ...
Tópico(s): Advanced NMR Techniques and Applications
2010 - Elsevier BV | Biological Psychiatry
Marc Doelken, Angelika Mennecke, Andreas Stadlbauer, S. Kloska, Tobias Struffert, Tobias Engelhorn, Norbert Thuerauf, Arnd Doerfler, Hermann Stefan, Thilo Hammen,
... total N-acetyl aspartate [tNAA], glutamate plus glutamine [Glx], total choline [tCho], myoinositol [mI], and total creatine [ ... The total magnitude of variation was greatest for Glx, followed by tNAA, mI, tCho, and tCr. Glx/tCr, Glx, and tCr were increased in gray matter, while ... anterior-to-posterior increases of tNAA/tCr and Glx/tCr, respectively tNAA and Glx, along the midline in gray matter (cingulum); (2) ... total N-acetyl aspartate [tNAA], glutamate plus glutamine [Glx], total choline [tCho], myoinositol [mI], and total creatine [ ...
Tópico(s): Advanced Neuroimaging Techniques and Applications
2009 - Elsevier BV | Academic Radiology
Tuhin Kumar Pal, Ramasubbu Sankararamakrishnan,
... aspartic acid (Asx) and glutamine and glutamic acid (Glx) can approach their own backbone nitrogen or carbonyl ... systematically analyzed intra-residue contacts in Asx and Glx residues and their secondary structure preferences in two ... resolution structures. Intra-residue contact in an Asx/Glx residue between the heavy atoms of side-chain ... and 1462 cases of self-contacting Asx and Glx residues from the two datasets. Two important observations ... oxygens of a significant number of Asx and Glx residues approach each other. For a wide-range ...
Tópico(s): RNA and protein synthesis mechanisms
2008 - Elsevier BV | Journal of Molecular Graphics and Modelling
Wenzhen Zhu, Weide Zhong, Qi Jianpin, Pin Yin, Chengyuan Wang, Li‐Wen Chang,
... HIE grading and prognosis. As a result, the GLx-α peak was markedly increased in the moderate and severe HIE groups. The GLx-α/Cr ratio in the control, mild, moderate, ... rank correlation test confirmed that the ratio of GLx-α/Cr and Lac/Cr had significant positive ... clinical grading of HIE (P < 0.01). The GLx-α/Cr ratio in the dead, abnormal, and ... rank correlation test confirmed that the ratio of GLx-α/Cr and Lac/Cr had significant negative correlation with prognosis of HIE; GLx-α/Cr showed a much stronger correlation than ...
Tópico(s): Atomic and Subatomic Physics Research
2008 - Elsevier BV | Translational research
The cytotoxic response of an intermediate metabolite glyoxylate (Glx) on colon carcinoma has been evaluated in vitro.The anti-proliferative effect of Glx was assessed on HT-29 and HCT-116 ... beta-hexosaminidase assay. Evaluation of apoptotic event of Glx treated cells was measured by flow cytometry using ... results of MTT assay indicated that treatment with Glx significantly inhibited the proliferation of HT-29 and ... the inhibition of cellular viability. The dose-dependent Glx treatment indicated lowering the colony forming ability of ...
Tópico(s): Inflammatory mediators and NSAID effects
2007 - Elsevier BV | Cancer Detection and Prevention
Toki Taira, Atsuko OHDOMARI, Naoya NAKAMA, Makiko Shimoji, Masanobu Ishihara,
Three chitinases, designated gazyumaru latex chitinase (GLx Chi)-A, -B, and -C, were purified from the latex of gazyumaru (Ficus microcarpa). GLx Chi-A,-B, and -C are an acidic ... class II chitinase (27 kDa, pI>10) respectively. GLx Chi-A did not exhibit any antifungal activity. At low ionic strength, GLx Chi-C exhibited strong antifungal activity, to a similar extent as GLx Chi-B. The antifungal activity of GLx Chi-C became weaker with increasing ionic strength, whereas that of GLx Chi-B became slightly stronger. GLx Chi-B ...
Tópico(s): Enzyme Production and Characterization
2005 - Oxford University Press | Bioscience Biotechnology and Biochemistry
Thorsten Irsch, R. Luise Krauth‐Siegel,
... lesser extent with adenine and cytosine. Glyoxalase I (GLX I) 1The abbreviations used are: GLX I, glyoxalase I; GLX II, glyoxalase II; MES, 2-(N-morpholino)ethanesulfonic ... The thioester is subsequently hydrolyzed by glyoxalase II (GLX II) yielding d-lactate and regenerating glutathione. Trypanosomatids ... reagents of the highest quality. T. brucei His6-GLX II—The coding region of the glxII gene ... both directions. For overexpression of T. brucei His6-GLX II, a 1-liter culture of recombinant NovaBlue ... to grow overnight at 15 °C. T. brucei GLX II—For overexpression of tag-free T. brucei ...
Tópico(s): Advanced Glycation End Products research
2004 - Elsevier BV | Journal of Biological Chemistry
The cytotoxic response of an intermediate metabolite glyoxylate (Glx) on colon carcinoma has been evaluated in vitro.The anti-proliferative effect of Glx was assessed on HT-29 and HCT-116 ... beta-hexosaminidase assay. Evaluation of apoptotic event of Glx treated cells was measured by flow cytometry using ... results of MTT assay indicated that treatment with Glx significantly inhibited the proliferation of HT-29 and ... the inhibition of cellular viability. The dose-dependent Glx treatment indicated lowering the colony forming ability of ...
Tópico(s): Inflammatory mediators and NSAID effects
1999 - Elsevier BV | Current Opinion in Cell Biology
Hasan M. Agha, Ahmed Saud Abdulhameed, Ali H. Jawad, Norrizah Jaafar Sidik, Shafiq Aazmi, Zeid A. ALOthman, Lee D. Wilson, Sameer Algburi,
... of cross-linked chitosan-glyoxal/algae biocomposite (CHT-GLX/ALG) adsorbent was developed through an innovative hydrothermal cross-linking method. The CHT-GLX/ALG biocomposite was characterized using several complementary analytical ... EDX, and pHpzc. This new adsorbent, named CHT-GLX/ALG, was utilized for the adsorption of a ... adsorption process involved key parameters is listed: CHT-GLX/ALG dosage (from 0.02 to 0.1 ... empirical data of MV 2B adsorption by CHT-GLX/ALG exhibited favorable agreement with the Freundlich isotherm ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2023 - Elsevier BV | International Journal of Biological Macromolecules
Gita Anjali Narayan, Kathryn Hill, Kenneth Wengler, Xiang He, Junying Wang, Jie Yang, Ramin V. Parsey, Christine DeLorenzo,
... studies examine the ratio of glutamate and glutamine (Glx) to GABA (Glx/GABA) as it relates to depressive symptoms, which ... reduction in depressive symptoms correlates with reduction in Glx/GABA in the anterior cingulate cortex (ACC). The ... clinical trial that utilized 1H-MRS to examine Glx/GABA before and after 8 weeks of escitalopram ... with a water unsuppressed reference scan. GABA and Glx were quantified from the average difference spectrum, with ... relationships between change in HDRS17 and change in Glx/GABA using a univariate linear regression model, multiple ...
Tópico(s): Functional Brain Connectivity Studies
2022 - Springer Nature | Molecular Psychiatry
Iska Moxon‐Emre, Zafiris J. Daskalakis, Daniel M. Blumberger, Paul E. Croarkin, Rachael E. Lyon, Natalie J. Forde, Hideaki Tani, Peter Truong, Meng‐Chuan Lai, Pushpal Desarkar, Napapon Sailasuta, Péter Szatmári, Stephanie H. Ameis,
... whether an excitatory rTMS treatment course modulates glutamatergic (Glx) or γ-aminobutyric acid (GABA) metabolite levels in ... 4.47 years; six-female]. Metabolite levels for Glx and GABA+ were compared between ASD and control ... underwent active vs. sham rTMS. Absolute change in Glx was greater in the active vs. sham-rTMS ... groups. rTMS group moderated the relation between baseline Glx and pre-to-post-rTMS Glx change, such that baseline Glx predicted Glx change in the active-rTMS group only [b = ... 32, t(18) = 4.74, p < 0.001]; Glx levels increased when baseline levels were lower, and ...
Tópico(s): Autism Spectrum Disorder Research
2021 - Frontiers Media | Frontiers in Neuroscience
Charles P. Lewis, John D. Port, Caren J. Blacker, Ayse Irem Sonmez, Bhedita J. Seewoo, Jarrod M. Leffler, Mark A. Frye, Paul E. Croarkin,
... used to determine the ability of glutamate+glutamine (Glx) and the N-acetylaspartate (NAA)/Glx ratio to discriminate Dep/SI- and Dep/SI+ adolescents. Dep/SI+ adolescents had higher Glx than Dep/SI- participants (padj = 0.012) and had lower NAA/Glx than both Dep/SI- (padj = 0.002) and ... There were significant relationships between SI intensity and Glx (pFDR = 0.026), SI severity and NAA/Glx (pFDR = 0.012), and SI intensity and NAA/Glx (pFDR = 0.004). ACC Glx and NAA/Glx discriminated Dep/SI- from Dep/SI+ participants. Uncoupled ...
Tópico(s): Bipolar Disorder and Treatment
2020 - Springer Nature | Translational Psychiatry
Branislava Ćurčić‐Blake, Leonie Bais, Anita Sibeijn‐Kuiper, Hendrika Maria Pijnenborg, Henderikus Knegtering, Edith J. Liemburg, André Alemán,
... psychosis. In this study, levels of glutamate + glutamine (Glx) in the left lateral prefrontal lobe were determined ... magnetic resonance spectroscopy (MRS) to estimate levels of Glx in the white matter of the left prefrontal ... group; n = 22) to control participants. Levels of Glx were significantly different between the groups (F(2, ... p = 0.007). Planned comparisons showed that higher Glx levels were found in control participants than in ... patients with lifetime AVH had higher levels of Glx compared to patients without lifetime AVH (p = 0. ...
Tópico(s): Functional Brain Connectivity Studies
2017 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Ema Kantorová, Hubert Poláček, Michal Bittšanský, Eva Baranovičová, Petra Hnilicová, Daniel Čierný, Štefan Sivák, Vladimír Nosáľ, Kamil Zeleňák, Egon Kurča,
... MRS) of the hypothalamus. Concentrations of glutamate + glutamin (Glx), cholin (Cho), myoinositol (mIns), N-acetyl aspartate (NAA) ... Cr and NAA/Cr ratios were decreased and Glx/NAA ratio increased in MS patients vs CON. Glx/NAA, Glx/Cr, and mIns/NAA were significantly higher in ... 2) vs non-active MS patients (RIO 0). Glx/NAA and Glx/Cr correlated with MSSS and fatigue score, and Glx/Cr with depressive score of MS patients. In CON, relationships between Glx/Cr and age, and Glx/NAA and fatigue score were inverse.Conclusion: Our ...
Tópico(s): Peripheral Neuropathies and Disorders
2017 - Taylor & Francis | Neurological Research
Manish Nagpal, Sangita Marlecha, Kamal Nagpal,
... using a 532-nm solid-state green laser (GLX) versus a multispot 532-nm pattern scan laser ( ... Each patient underwent panretinal photocoagulation: one eye with GLX and the other with PASCAL, two sittings per ... retinal sensitivity were compared.Pattern scan laser and GLX required an average fluence of 40.33 vs ... minutes with PASCAL and 4.53 minutes with GLX. Average visual analog scale reading for GLX was 4.6, whereas that for PASCAL was ... 430 versus 310 microm at 3 months with GLX and PASCAL. The eyes treated with PASCAL showed ...
Tópico(s): Ophthalmology and Visual Impairment Studies
2010 - Lippincott Williams & Wilkins | Retina
... METH exposure. Therefore, concentrations of brain glutamate + glutamine (GLX) were assessed during abstinence from chronic METH abuse. ... been abstinent for 2.1 ± 3.0 months. GLX was measured in the basal ganglia and frontal ... matter, using proton magnetic resonance spectroscopy. While overall GLX concentrations at baseline were similar between METH and ... month of abstinence showed reduced frontal gray matter GLX (p = 0.01). Time of abstinence correlated positively with GLX in frontal gray (p < 0.0001) and white ...
Tópico(s): Forensic Toxicology and Drug Analysis
2008 - Springer Science+Business Media | Journal of Neuroimmune Pharmacology
Ivanka Savić, Ankur Thomas, Yuhe Ke, John Curran, Itzhak Fried, Jerome Engel,
... of N-acetyl aspartate (NAA), and glutamine+glutamate (Glx), are interictally altered in the epileptogenic regions of patients with partial seizures. Material and methods– NAA, Glx, creatine (Cr), choline (Cho) and myo-inositol (mI) ... 18 and neocortical in 10 patients. Results– The Glx/NAA and Glx/Cr ratios in epileptogenic regions were higher, and ... epileptogenic regions were correctly identified by an increased Glx/NAA and 15 of 20 by a decreased ... Cr ratio. Among patients with neocortical epilepsy the Glx/NAA ratio was increased in 8 of the ...
Tópico(s): Neuroscience and Neuropharmacology Research
2000 - Wiley | Acta Neurologica Scandinavica
Tiffany Bell, Elodie Boudes, Rachelle S. Loo, Gareth J. Barker, David J. Lythgoe, Richard A.E. Edden, R. Marc Lebel, Martin Wilson, Ashley D. Harris,
... was to examine the agreement of Glu and Glx (the combined signal of glutamate + glutamine) quantified from ... MMSup, T E = 80 ms) with Glu and Glx quantified from a short‐echo PRESS (PRESS‐35, ... voxel size of 3 × 3 × 3 cm 3 . Glx and Glu were quantified from the MEGA‐PRESS ... analyses, Bland–Altman plots and intraclass correlation coefficients. Glx quantified from the OFF sub‐spectra from both ... was not replicated in the anterior cingulate cortex. Glx and Glu quantified using the DIFF spectra of ... 35 data in both brain regions. In conclusion, Glx and Glu measured from MEGA‐PRESS data generally ...
Tópico(s): Electron Spin Resonance Studies
2020 - Wiley | NMR in Biomedicine