Directory of Open Access Journals (DOAJ)
... and Papers. 1816, January to February. Letter. From Gnt. Allison. Huddersfield.
0000 - Gale Group | NCCO BritishPolitics
Wanli Song, Caixia Liang, Yuhan Sun, Sayaka Morii, Shin Yomogida, Tomoya Isaji, Tomohiko Fukuda, Qinglei Hang, Akiyoshi Hara, Miyako Nakano, Jianguo Gu,
... that the expression levels of N-acetylglucosaminyltransferase III (GnT-III) mRNA and its products, bisected N-glycans, ... upregulations were sufficiently suppressed by the overexpression of GnT-III in K562/ADR cells. We found that the expression of GnT-III consistently decreased chemoresistance for doxorubicin and dasatinib, ... TNFR1, contains bisected N-glycans. The lack of GnT-III strongly induced TNFR2's autotrimerization without ligand stimulation, which was rescued by the overexpression of GnT-III in K562/ADR cells. Furthermore, the deficiency ...
Tópico(s): Helicobacter pylori-related gastroenterology studies
2023 - Elsevier BV | Journal of Biological Chemistry
John Coleman, Barbara Hall, Averil Burgess, P Elphick, M Stringer, Bakewell, Deputy City Editor Judi Bevan, John Davison, Anthony Clare, John Peter, Amanda Robertson-Day, Jonathan Miller, Eric Dymock, Jill Hartley, Christopher Smallwood Economics Editor, Brian Deer Social Affairs Correspondent, Sarah Miller, Nick Rufford, John Diamond, Diana Wright Personal Finance Editor, Alistair Scott, Sally Payne, Ian Williams Business Correspondent, Stephen Milligan, Russell Taylor, Diana Vreeland, Jason Tomas, Mark Hosenball, Virginia Price Evans, John Westwell, Jon Craig, Geordie Greig, (The Rev) Michael Manning, Michael Kustow Commissioning Editor, Patrick Stoddart, Robert Sandall, Alex Sutherland, Iain Johnstone, Susan Marling, John Russell, Lis Leigh, David Brierley, Irwin Stelzer, Peter Godwin, Ivan Fallon, Mick Brown, Keith Botsford, David Dougill, John Gildert, Christine Walker, Philip Beresford Industrial Editor, John Witherow, James Cusick, Egon Ronay, Lenin, Justine Picardie, Russell Harty, Susan Crosland, Peter Kemp, John Ballantine, Norman Harris, Andrew Scott, Geoff Whitten, Anne Moffat, George Perry, Sue Mott, Doune Porter, John Cassidy, Bernard Cafferty, Brian Moynahan, Frank Carlucci, Marie Colvin Middle East Correspondent, J Robinson Chairman, Simon Tang, Paul Driver, James Adams, Boris Schapiro, Richard Binns, Douglas Ginsburg, David Hughes, Tim Rayment, (The Rt Revd) Stewart Cross, J Hall Williams Emeritus Professor of Criminology, Patricia Miller, Elizabeth Grice, David Lawrenson, John Hopkins, Askold Krushelnycky, Denys Henderson, Brian Walden, Gareth David, Brian Reading, Simon Freeman, Stephen Pile, Gareth Huw Davies, G R Elton, Stanley Levenson, Malcolm Winton, Marie Colvin, Diana Wright, Christopher Smallwood, D McMurtrie, Margaret Rose, Stephen Jones, Michel Syrett, Norman Lebrecht, Richard Palmer, Mitchell Wheat, Keith Wheatley, Bob Rodwell, Scott Wallace, Stephen Davis, Colin McDowell, Rosemary Bailey, Dilys Powell, Chris Jones, Charles Oulton Religious Affairs Correspondent, Brough Scott, Russell Miller, Alison Beckett, Tony Rocca, Richard Lydiker Director, Norman Stone, Richard Woods, Hugh Clayton, Louise Branson, Elisabeth Winkler, Maurice Chittenden, Iola Smith, Dudley Doust, Barrie Penrose, Richard Ehrlich, Ian Dunning, David Hughes Political Correspondent, Brian MacArthur, Eileen Morrison, Michael Jones Political Editor, Dr Peter Abbs, Steve Tongue, Michael Smith, Philip Beresford, Godfrey Smith, B Mackey, Annabel Walker, Charles Oulton, Brian Glanville, Hal Rubenstein, Angus Roxburgh, John Carey, Alan Jenkins, Edward Pearce, Dr H Harvey Wood Director, Simon Jenkins, Robert Heller, Deirdre Fernand, Jon Craig Home Affairs Correspondent, Godfrey Golzen, Liam Clarke, David Jacob, Hugh Thompson, Arthur Miller, Ian Williams, Simon Rose, Karl Lagerfeld, Helen Mason, Valerie Grove, Hugh Pearman, Marina Vaizey, John Bayley, Roy Isacovitz, Marta Wöhrle, Margaret Park, Karena Callen, Hugh Sebag-Montefiore, Bill Cotton, Tony Hetherington, Milo Hillacre-Richards, Peter Roebuck, Joanna Simon, Michael Meacher, Martin Wren-Hilton, Juliet Butler, James Adams Defence Correspondent, Muriel Bowen,
... s vigour will help them overcome the Australians GNT We've Got the Property We'll Get ...
1987 - Gale Group | Sunday Times HA GDA
Jian Li, Penghua Ying, Ting Liang, Yao Du, Jianli Zhou, Jin Zhang,
... coaxial carbon nanotube (CNT) inside a graphyne nanotube (GNT), i.e., CNT@GNT, are investigated in this paper by using molecular ... results show that the mechanical properties of CNT@GNT under uniaxial tension depend on the nanotube chirality ... Specifically, the Young's modulus of the CNT@GNT structure with an inner zigzag CNT is larger ... its counterpart with an armchair CNT, while CNT@GNT with an armchair CNT and a zigzag GNT is found to possess the largest tensile strength ... of its two components is observed in CNT@GNT. The thermal conductivity of CNT@GNT is found ...
Tópico(s): Graphene research and applications
2023 - Royal Society of Chemistry | Physical Chemistry Chemical Physics
Reina F. Osuka, Tetsuya Hirata, Masamichi Nagae, Miyako Nakano, Hiroyuki Shibata, Ryo Okamoto, Yasuhiko Kizuka,
N-acetylglucosaminyltransferase-V (GnT-V or MGAT5) catalyzes the formation of an N-glycan β1,6-GlcNAc branch on selective target proteins in ... autoimmune disease etiology. Several three-dimensional structures of GnT-V were recently solved, and the recognition mechanism ... was clarified. However, it is still unclear how GnT-V selectively acts on glycoprotein substrates. In this ... side of the luminal region (N domain) of GnT-V, which was previously identified in a crystal structure, and aimed to reveal its role in GnT-V action. Using lectin blotting and fluorescence assisted ...
Tópico(s): Galectins and Cancer Biology
2022 - Elsevier BV | Journal of Biological Chemistry
Amol M. Vibhute, Hidenori Tanaka, Sushil Kumar Mishra, Reina F. Osuka, Masamichi Nagae, Chizuko Yonekawa, Hiroaki Korekane, Robert J. Doerksen, Hiromune Ando, Yasuhiko Kizuka,
... regulates various functions of glycoproteins. N-Acetylglucosaminyltransferase V (GnT-V) is a GlcNAc transferase that acts on N-glycans and the GnT-V-producing branch is highly related to cancer progression. This indicates that specific GnT-V inhibitors may be drug candidates for cancer treatment. To design novel GnT-V inhibitors, we focused on the unique and ... recognition of the donor substrate UDP-GlcNAc by GnT-V. On the basis of the catalytic pocket ... UDP-GlcNAc analogs with increasing hydrophobicity may be GnT-V inhibitors. Methods: We chemically synthesized 10 UDP- ...
Tópico(s): Galectins and Cancer Biology
2022 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - General Subjects
Tetsuya Hirata, Misaki Takata, Yuko Tokoro, Miyako Nakano, Yasuhiko Kizuka,
... of the branch produced by N -acetylglucosaminyltransferase-V (GnT-V, also called as MGAT5) promotes cancer growth ... it is largely unknown how the activity of GnT-V in cells is regulated. Here, we discover that the activity of GnT-V in cells is selectively upregulated by changing ... in an increase in the amount of the GnT-V-produced branch. Mechanistically, shedding (cleavage and extracellular secretion) of GnT-V mediated by signal peptide peptidase-like 3 ( ... N -glycans, resulting in an increased level of GnT-V protein in cells. Alteration of cellular N - ...
Tópico(s): Peptidase Inhibition and Analysis
2022 - Nature Portfolio | Communications Biology
Naoko Osada, Masamichi Nagae, Miyako Nakano, Tetsuya Hirata, Yasuhiko Kizuka,
... which correlates with various diseases. N-Acetylglucosaminyltransferase-IVa (GnT-IVa or MGAT4A) and Gnt-IVb (or MGAT4B) are isoenzymes that catalyze the ... and UDP-Glo enzyme assays, we discovered that GnT-IVa and GnT-IVb have distinct glycoprotein preferences both in cells and in vitro. Notably, we show that GnT-IVb acted efficiently on glycoproteins bearing an N-glycan premodified by GnT-IV. To further understand the mechanism of this ... Replacement of a nonconserved amino acid in the GnT-IVb lectin domain with the corresponding residue in ...
Tópico(s): Galectins and Cancer Biology
2022 - Elsevier BV | Journal of Biological Chemistry
Sho Oshima, Taira Sato, Michiyo Honda, Yasushi Suetsugu, Kazuhide Ozeki, Masanori Kikuchi,
A gentamicin-loaded hydroxyapatite/collagen bone-like nanocomposite (GNT-HAp/Col) was fabricated and evaluated for its ... HAp/Col) powder was mixed with gentamicin sulfate (GNT) in phosphate-buffered saline (PBS) at room temperature. After 6 h mixing, the GNT adsorption in all conditions reached plateau by Langmuir’s isotherm, and maximum GNT adsorption amount was 34 ± 7 μg in 250 μg/mL GNT solution. Saturated GNT-loaded HAp/Col powder of 100 mg was ... of PBS at 37 °C and released all GNT in 3 days. A shaking culture method for ...
Tópico(s): Orthopedic Infections and Treatments
2020 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Miyako Nakano, Sushil Kumar Mishra, Yuko Tokoro, Keiko Sato, Kazuki Nakajima, Yoshiki Yamaguchi, Naoyuki Taniguchi, Yasuhiko Kizuka,
... mice lacking the biosynthetic enzyme of bisecting GlcNAc, GnT-III, and was conversely suppressed by GnT-III overexpression in cells. Many glycosyltransferases for N- ... expression of the terminal N-glycan epitopes in GnT-III-deficient mice is attributed to the substrate ... mice lacking the biosynthetic enzyme of bisecting GlcNAc, GnT-III, and was conversely suppressed by GnT-III overexpression in cells. Many glycosyltransferases for N- ... expression of the terminal N-glycan epitopes in GnT-III-deficient mice is attributed to the substrate ...
Tópico(s): Galectins and Cancer Biology
2019 - Elsevier BV | Molecular & Cellular Proteomics
Amin Reihani, Alireza Soleimani, Sajad Kargar, Veera Sundararaghavan, Ali Ramazani,
... conductivity and phonon transport properties of graphyne nanotubes (GNTs) and conventional carbon nanotubes (CNTs) are studied using ... higher for CNTs in comparison to that of GNTs across the entire ballistic–diffusive transport range. Among GNTs, β- and γ-GNTs demonstrated the lowest and highest thermal conductivities, respectively. ... 4.5–7.6 nm) was observed in GNTs, which was significantly lower compared to CNTs. This ... at lengths up to 200 nm for both GNTs and CNTs; however, the rate of increase in ...
Tópico(s): Graphene research and applications
2018 - American Chemical Society | The Journal of Physical Chemistry C
Priyanka Jain, Subhash Chandra Sethi, Pratyusha Vavilala, Pramita Garai, Nilofer Naqvi, Sonali Singh, Kalpana Pawar, Niti Puri, Sneha Sudha Komath,
... C. albicans Ras proteins, CaRas1 alone activates GPI–GnT activity; activity is further stimulated by constitutively activated ... or endoplasmic reticulum (ER) is sufficient for GPI–GnT activation. Of the six subunits of the GPI–N-acetylglucosaminyltransferase (GPI–GnT) that catalyze the first step of GPI biosynthesis, ... is independent of the catalytic competence of GPI–GnT. This too is unlike what is observed in ... explain the ability of CaRas1 to activate GPI–GnT. CaGpi2, in turn, promotes activation of the Ras- ...
Tópico(s): Polyamine Metabolism and Applications
2018 - Elsevier BV | Journal of Biological Chemistry
Qinyin Deng, Nanlin Yin, Ying Chen, Nan Shan, Xiru Liu, Hongbo Qi,
... Many studies have confirmed that N-acetylglucosaminyltransferase III (GnT-III) is correlated with tumor invasion and metastasis. However, the expression of GnT-III and its role in normal pregnancy and ... primary objective of this study is to determine GnT-III expression in normal pregnancy and whether its ... preeclampsia (PE) were used for the detection of GnT-III expression. Human first trimester extravillous trophoblast cell ... model in vitro to investigate the expression of GnT-III.Results: GnT-III was strongly expressed in ...
Tópico(s): RNA modifications and cancer
2018 - Informa | The Journal of Maternal-Fetal & Neonatal Medicine
Masamichi Nagae, Yasuhiko Kizuka, Emiko Mihara, Yu Kitago, Shinya Hanashima, Yukishige Ito, Junichi Takagi, Naoyuki Taniguchi, Yoshiki Yamaguchi,
Abstract N -acetylglucosaminyltransferase-V (GnT-V) alters the structure of specific N -glycans by modifying α1-6-linked mannose with a β1-6-linked N - ... on cell surface receptors accelerates cancer metastasis, making GnT-V a promising target for drug development. However, the molecular basis of GnT-V’s catalytic mechanism and substrate specificity are ... understood. Here, we report crystal structures of human GnT-V luminal domain with a substrate analog. GnT-V luminal domain is composed of a GT- ... conformation, partly explaining the fine branch specificity of GnT-V. In addition, interaction of the substrate N - ...
Tópico(s): Galectins and Cancer Biology
2018 - Nature Portfolio | Nature Communications
Paweł Link-Lenczowski, Monika Bubka, Crina I.A. Balog, Carolien A. M. Koeleman, Terry D. Butters, Manfred Wuhrer, Anna Lityń́ska,
N-acetylglucosaminyltransferase III (GnT-III) is known to catalyze N-glycan "bisection" and thereby modulate the formation of highly branched complex structures within ... the action of other GlcNAc transferases such as GnT-IV and GnT-V. Moreover, GnT-III is considered as an inhibitor of the ... vitro and in vivo. However, the effects of GnT-III may be more diverse and depend on ... the detailed glycomic analysis of the effect of GnT-III overexpression in WM266–4-GnT-III metastatic melanoma cells. We used MALDI-TOF ...
Tópico(s): Galectins and Cancer Biology
2018 - Springer Science+Business Media | Glycoconjugate Journal
U. Srimathi, V. Nagarajan, R. Chandiramouli,
... ripening stages of banana fruit on germanene nanotube (GNT). Initially, the geometric structural stability of GNT is ascertained and the tunable electronic properties lead to the application of GNT as a base material in order to know ... explored the adsorption behavior of VOCs on to GNT through charge transfer, adsorption energy and band gap ... upon adsorption of different VOCs on to the GNT. Also, the electron density variation is noticed upon ... VOCs emitted from the banana on to the GNT base material. Besides, the difference in the energy ...
Tópico(s): Molecular Junctions and Nanostructures
2018 - Elsevier BV | Journal of Molecular Graphics and Modelling
Heba Allam, Blake Johnson, Mao Zhang, Zhongpeng Lu, Martin J. Cannon, Karen L. Abbott,
... discovered that the gene Mgat3 encoding the glycosyltransferase GnT-III is elevated in epithelial ovarian carcinomas (EOCs) ... have discovered using stable shRNA gene suppression that GnT-III expression controls the expansion of side-population ... cancer stem cells. More specifically, we found that GnT-III expression regulates the levels and activation of ... involved in normal and malignant development. Suppression of GnT-III in EOC cell lines and primary tumor- ... transport and demonstrate the therapeutic potential of inhibiting GnT-III as a treatment for controlling EOC growth ...
Tópico(s): Cancer Cells and Metastasis
2017 - Elsevier BV | Journal of Biological Chemistry
Kimihiro Nishino, Eiko Yamamoto, Kaoru Niimi, Yoko Sekiya, Yoriko Yamashita, Fumitaka Kikkawa,
... normal placenta or hydatidiform mole. N-acetylglucosaminyltransferase IV (GnT-IV) is a glycosyltransferase which catalyses the formation ... present study was to understand the role of GnT-IVa in choriocarcinoma and find the target proteins for GnT-IVa glycosylation which contribute to the malignancy of ... showed that Griffonia simplicifolia lectin-II staining and GnT-IVa staining were intense in trophoblastic cells of ... choriocarcinoma. We established a choriocarcinoma cell line with GnT-IVa overexpression (Jar-GnT4a), and examined its malignant ...
Tópico(s): Prenatal Screening and Diagnostics
2017 - Elsevier BV | Oncology Reports
Ali Ramazani, Amin Reihani, Alireza Soleimani, Ronald G. Larson, Veera Sundararaghavan,
... conductivities of α, β, and γ graphyne nanotubes (GNTs) as well as of carbon nanotubes (CNTs) using ... temperature range 50–400 K. We find that GNTs demonstrate considerably lower thermal conductivity than CNTs with ... diameter and length. Among α, β, and γ-GNTs, γ-GNT has the highest thermal conductivity at all temperatures. By comparing the phonon transport properties of GNTs with CNTs, we find that as the fraction ... free path, adversely affecting the thermal conductivity of GNTs relative to CNTs. Also reducing the thermal conductivity ...
Tópico(s): Graphene research and applications
2017 - Elsevier BV | Carbon
Na Zhang, Yan Qi, Haijun Zhang, Xiaoyun Wang, Hongfei Li, Yantong Shi, Yang‐Dong Guo,
Genistein (GNT), an isoflavone, is used in the clinical treatment of various health disorders. GNT is found in primary food source plants and ... medical plants. However, studies on the functions of GNT in plants are rarely reported. In this study, we demonstrated that GNT plays an important role in promoting anthocyanin accumulation in red cabbage. GNT solutions (10, 20, 30, 40, and 50 mg/ ... red cabbage increased in a light-dependent manner. GNT solution at 30 mg/L exhibited the optimal ... control. Quantitative real-time PCR analysis indicated that GNT application upregulated the expression of all structural genes, ...
Tópico(s): Light effects on plants
2016 - Frontiers Media | Frontiers in Plant Science
... erythropoietin (EPO) in a HEK293S N-acetylglucosaminyltransferase I (GnT I)−/− cell line resulted in production of the ... than 50% were core-fucosylated, implicating a clear GnT I-independent core fucosylation pathway. Expression of GM- ... nature of the recombinant proteins. To elucidate the GnT I-independent core fucosylation pathway, we generated a stable HEK293S GnT I−/− cell line with either knockdown or overexpression ... fucosyltransferase, is the sole enzyme responsible for the GnT I-independent core fucosylation pathway. The production of ...
Tópico(s): Galectins and Cancer Biology
2016 - Elsevier BV | Journal of Biological Chemistry
Jishun Lu, Tomoya Isaji, Sanghun Im, Tomohiko Fukuda, Akihiko Kameyama, Jianguo Gu,
N-Acetylglucosaminyltransferase III (GnT-III), which catalyzes the addition of the bisecting GlcNAc branch on N-glycans, is usually described as a metastasis suppressor. Overexpression of GnT-III inhibited migration in multiple types of tumor ... the clinical observations for the increased expression of GnT-III in human hepatomas, glioma, and ovarian cancers. ... sialylation. In detail, we show that overexpression of GnT-III significantly inhibits α2,3-sialylation but not ... of α2,6-sialylation is consistently suppressed after GnT-III overexpression. In contrast, the effects of GnT- ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2016 - Elsevier BV | Journal of Biological Chemistry
Brian D. Holt, Justin J. Law, Patrick D. Boyer, Lon J. Wilson, Kris Noel Dahl, Mohammad F. Islam,
... carbon nanotubes, also referred to as gadonanotubes or GNTs, exhibit ∼40 times the relaxivities of clinical CAs, ... and MRI studies have suggested great promise for GNTs, relatively little is known regarding their subcellular interactions, which are crucial for further, safe development of GNTs as CAs. In this work, we administered GNTs to a well-established human cell line (HeLa) and to murine macrophage-like cells (J774A.1). GNTs were not acutely cytotoxic and did not reduce ... for J774A.1 macrophages, yet bulk uptake of GNTs occurred in minutes at picogram quantities, or millions ...
Tópico(s): Molecular Communication and Nanonetworks
2015 - American Chemical Society | ACS Applied Materials & Interfaces
Juan Pablo Rigalli, Nadia Ciriaci, Agostina Arias, María Paula Ceballos, Silvina Stella Maris Villanueva, Marcelo G. Luquita, Aldo D. Mottino, Carolina I. Ghanem, Viviana A. Catania, María Laura Ruiz,
... drugs that are substrates of these transporters. Genistein (GNT) is a phytoestrogen abundant in soybean that exerts ... above-mentioned transporters. We evaluated the effect of GNT on the expression and activity of P-gp, ... MRP3 and BCRP in HCC-derived HepG2 cells. GNT (at 1.0 and 10 μM) increased P- ... as detected by the methylthiazole tetrazolium (MTT) assay. GNT induced P-gp and MRP2 mRNA expression at ... Induction of both transporters by 1.0 μM GNT was prevented by cycloheximide, suggesting translational regulation. Downregulation ...
Tópico(s): Genomics, phytochemicals, and oxidative stress
2015 - Public Library of Science | PLoS ONE
Chunyue Huang, Miaojuan Huang, Wenxia Chen, Weiliang Zhu, Hui Meng, Linlang Guo, Ting Wei, Jian Zhang,
N-acetylglucosaminyltransferase V (Gnt-V) has been linked to the migration of various human cancers. Recently we have found that inhibition of Gnt-V increases the radiosensitivity of cancer cells. However, the mechanisms by which Gnt-V mediates radiosensitivity and migration, especially in small ... H1688 and H146) were used to investigate whether Gnt-V modulated the radiosensitivity and migration of SCLC ... EMT). The results showed that the expression of Gnt-V correlated with the N stage in patients with SCLC. Overexpression of Gnt-V led to a further increase in the ...
Tópico(s): Cancer Cells and Metastasis
2015 - Wiley | FEBS Journal
Binbin Huang, Qiong Wu, Yanli Ge, Junjie Zhang, Longe Sun, Yunyun Zhang, Liu Fu, Juanjuan Fan, Zhirong Wang,
N-acetylglucosaminyltransferase V (GnT-V) is an enzyme that catalyzes β1-6 branching of N-acetylglucosamine on asparagine (N)-linked oligosaccharides (N-glycan) ... feature of various carcinomas. Nevertheless, the role of GnT-V remains controversial. Therefore, the clinical implication of GnT-V expression may differ in each cancer type. The implication of GnT-V status in patients with gastric cancer has ... studied extensively. In the present study, we examined GnT-V expression in gastric cancer specimen both at ...
Tópico(s): Proteoglycans and glycosaminoglycans research
2014 - Spandidos Publishing | International Journal of Oncology
Na Li, Haineng Xu, Kun Fan, Xijun Liu, Jingjing Qi, Chao Zhao, Yin Peng, Liying Wang, Zengxia Li, Xiliang Zha,
... and cell biological characteristics. N ‐acetylglucosaminy transferase V (GnT‐V), a key enzyme catalysing the reaction of ... non‐small cell lung cancers, low level of GnT‐V expression is associated with relatively short survival ... and poor prognosis. To explain the role of GnT‐V in lung cancer progression, we studied the association of GnT‐V expression with lung cancer EMT behaviour. We found that GnT‐V expression was correlated with epithelial marker positively and mesenchymal marker negatively. GnT‐V levels, as well as β1,6‐Glc ...
Tópico(s): Cancer Cells and Metastasis
2014 - Wiley | Journal of Cellular and Molecular Medicine
Valery Matthys, Velasco Cimica, Nadine A. Dalrymple, Nicole B. Glennon, Christopher Bianco, Erich R. Mackow,
... harbor elements in their 142-residue cytoplasmic tails (GnTs) that inhibit RIG-I/MAVS/TBK1-TRAF3-directed IFN-β induction. Here, we define GnT interactions and residues required to inhibit TRAF3-TBK1- ... β induction and IRF3 phosphorylation. We observed that GnTs bind TRAF3 via residues within the TRAF-N ... domain (residues 415 to 568). We determined that GnT binding to TRAF3 is mediated by C-terminal degrons within NY-1V or ANDV GnTs and that mutations that add degrons to TULV or PHV GnTs confer TRAF3 binding. Further analysis of GnT domains ...
Tópico(s): Mosquito-borne diseases and control
2014 - American Society for Microbiology | Journal of Virology
Hua‐Bei Guo, Tamás Nagy, Michael Pierce,
Deletion of GnT-V (MGAT5), which synthesizes N-glycans with β(1,6)-branched glycans, reduced the compartment of cancer stem ... cancer, leading to delay of tumor onset. Because GnT-V levels are also commonly up-regulated in ... into NOD/SCID mice were positively associated with GnT-V levels, indicating regulation of proliferation and tumorigenicity. Using Apcmin/+ mice with different GnT-V backgrounds, knock-out of GnT-V had no significant effect on the number ... and accompanied increased survival of Apcmin/+ mice with GnT-V deletion (p < 0.01), suggesting an inhibition ...
Tópico(s): Cancer Cells and Metastasis
2014 - Elsevier BV | Journal of Biological Chemistry