Daniela Krause, Diana Plörer, Gabriele Koller, Gabi Martin, C. A. Winter, Roland Adam, Minavere Canolli, Jori Al-Iassin, Rainer Musselmann, Stephan Walcher, F. Schäfer, Oliver Pogarell,
Background: Concomitant opioid misuse is an increasing problem in opioid maintenance treatment as it interferes with treatment success. Objective: Therefore, the rates of concomitant fentanyl misuse in opioid maintained patients were investigated. Methods: We conducted a cross-sectional study which consisted in collecting data via urine samples and questionnaires in Germany. Urine samples of patients on opioid maintenance treatment were gathered and fentanyl concentrations were measured from 2008 ...
Tópico(s): Forensic Toxicology and Drug Analysis
2017 - Taylor & Francis | Substance Use & Misuse
Matthias C. Müller, Matthias Pichler, Gabi Martin, Diana Plörer, C. A. Winter, Oliver Pogarell, Johannes R. Bogner,
Tópico(s): HIV/AIDS Research and Interventions
2009 - Springer Nature | Medizinische Klinik
Daniela Schranner, Gabi Kastenmüller, Martin Schönfelder, Werner Römisch‐Margl, Henning Wackerhage,
Exercise changes the concentrations of many metabolites, which are small molecules (< 1.5 kDa) metabolized by the reactions of human metabolism. In recent years, especially mass spectrometry-based metabolomics methods have allowed researchers to measure up to hundreds of metabolites in a single sample in a non-biased fashion. To summarize human exercise metabolomics studies to date, we conducted a systematic review that reports the results of experiments that found metabolite concentrations changes ...
Tópico(s): Muscle metabolism and nutrition
2020 - Springer Nature | Sports Medicine - Open
Gabi Wetzel, Martin Heine, Arndt Rohwedder, Hassan Y. Naim,
Abstract Sucrase-isomaltase (SI) is a highly N- and O-glycosylated intestinal brush border membrane protein. SI is sorted with high fidelity to the apical membrane via O-linked glycans that mediate its association with lipid rafts or detergent-resistant membranes (DRMs). Here, we show that N- and O-glycosylation and DRMs are implicated in the regulation of the function of SI in intestinal Caco-2 cells. The activities of sucrase (SUC) and isomaltase (IM) increase substantially in DRMs when N- and O-glycosylation ...
Tópico(s): Diet, Metabolism, and Disease
2009 - De Gruyter | Biological Chemistry
Nicolas Rüsch, Ludger Tebartz van Elst, Gabi Valerius, Martin Büchert, Thorsten Thiel, Dieter Ebert, Jürgen Hennig, H Olbrich,
Executive dysfunction is a core feature of schizophrenia. The neurochemical and structural changes associated with this deficit are, however, largely unclear. This study tested the hypothesis that changes in glutamate, glutamine and N-acetyl-aspartate (NAA) in hippocampal and dorsolateral prefrontal (DLPFC) regions as well as hippocampal, amygdalar and DLPFC volume reductions are associated with executive dysfunction. Twenty-nine subjects with schizophrenia and 31 healthy controls were examined by ...
Tópico(s): Neuroscience and Neuropharmacology Research
2007 - Elsevier BV | Schizophrenia Research
Ludger Tebartz van Elst, Gabi Valerius, Martin Büchert, Thorsten Thiel, Nicholas Rüsch, Emanuel Bubl, Jürgen Hennig, Dieter Ebert, H. M. Olbrich,
Background Glutamatergic dysfunction has been implicated in the pathophysiology of schizophrenia. However, so far there is limited direct evidence of altered in vivo glutamate concentrations in the brains of patients with schizophrenia. To test the hypothesis that altered glutamatergic neurotransmission might play a role in the pathogenesis of schizophrenia, we measured glutamate and glutamine concentrations in the prefrontal cortex and the hippocampus of patients with chronic schizophrenia using ...
Tópico(s): Advanced NMR Techniques and Applications
2005 - Elsevier BV | Biological Psychiatry
Tanja Schlereth, Irini Mouka, Gabi Eisenbarth, Martin Winterholler, Frank Birklein,
Abstract Background Botulinum toxin type A (BoNT/A) is 20–50 times more effective than Botulinum toxin type B (BoNT/B) concerning the treatment of muscular hypercontractions [Sloop, R.R., Cole, B.A., Escutin, R.O., 1997. Human response to botulinum toxin injection: type B compared with type A. Neurology 49, 189–194]. Botulinum toxins block motor nerves as well as autonomic fibres [Rand, M.J., Whaler, B.C., 1965. Impairment of sympathetic transmission by botulinum toxin. Nature 206, 588–591]. Objective Purpose ...
Tópico(s): Neurological disorders and treatments
2004 - Elsevier BV | Autonomic Neuroscience
Lothar Schrott, Gabi Hufschmidt, Martin Hankammer, Thomas Hoffmann, Richard Dikau,
Tópico(s): Landslides and related hazards
2003 - Elsevier BV | Geomorphology
Petra Gastmeier, Günter Kampf, Nicoletta Wischnewski, Trina Hauer, Gabi Schulgen, Martin Schumacher, Franz Daschner, H. Rüden,
The nosocomial infection (NI) rate in German hospitals was studied in order to create reference data for comparison in hospitals where ongoing surveillance is impossible. The study was designed as a one-day prevalence study. Patients in 72 selected hospitals (inclusion criteria: acute care hospitals with departments for general medicine, surgery, obstetrics/ gynaecology) were examined by four external investigators (physicians trained and validated in the diagnosis of NI). A total of 14 996 patients ...
Tópico(s): Intensive Care Unit Cognitive Disorders
1998 - Elsevier BV | Journal of Hospital Infection
Günter Kampf, Nicoletta Wischnewski, Gabi Schulgen, Martin Schumacher, Franz Daschner,
The prevalence and risk factors for nosocomial lower respiratory tract infections (LRTI) in Germany were determined as part of a national survey on nosocomial infections. The study included 14,966 patients in 72 representatively selected hospitals with departments of general medicine, surgery, obstetrics, gynecology, and intensive care units (ICU). Surveillance was carried out by four previously validated medical doctors who strictly applied the CDC-criteria for diagnosis of nosocomial infections. ...
Tópico(s): Respiratory Support and Mechanisms
1998 - Elsevier BV | Journal of Clinical Epidemiology
T. Hauer, M Lacour, Petra Gastmeier, Gabi Schulgen, Martin Schumacher, H. Rüden, F. Daschner,
Tópico(s): Medical and Health Sciences Research
1996 - Springer Science+Business Media | Der Anaesthesist
Gabi Schulgen, Martin Schumacher,
Evaluation of the impact of nosocomial infection on duration of hospital stay usually relies on estimates obtained in prospective cohort studies. However, the statistical methods used to estimate the extra length of stay are usually not adequate. A naive comparison of duration of stay in infected and non-infected patients is not adequate to estimate the extra hospitalisation time due to nosocomial infections. Matching for duration of stay prior to infection can compensate in part for the bias of ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
1996 - Springer Science+Business Media | Lifetime Data Analysis
Manfred Olschewski, Gabi Schulgen, Martin Schumacher, DG Altman,
Classical end-points in clinical therapeutic trials in oncology are usually defined by total, recurrence-free or systemic disease-free survival.Primarily, these allow an adequate de- scription of the biological course of the disease.In current
Tópico(s): Childhood Cancer Survivors' Quality of Life
1994 - Springer Nature | British Journal of Cancer
Margit Kadletz, Heinz Magometschnigg, Erich Minar, Gabi König, Martin Grabenwöger, Michael Grimm, Ernst Wolner,
To assess the impact of in vitro endothelialization on prosthetic graft patency, we performed femorotibial reconstruction in four patients. Polytetrafluoroethylene grafts (6 mm), lined with cultivated autologous endothelial cells, harvested from the veins of the forearm, were used. Autologous endothelial cells were harvested enzymatically and characterized by morphology and factor VIII staining. After a cultivation period of 17 to 23 days, the cell count increased from 27 ± 3 × 104 endothelial cells ...
Tópico(s): Polymer Surface Interaction Studies
1992 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Tópico(s): Rheology and Fluid Dynamics Studies
2015 - Springer Science+Business Media | Journal of Thermal Science
Yasmine Gabi, Olivier Martins, Bernd Wolter, Benjamin Straß,
The paper considers the Rockwell hardness investigation by finite element simulation in inspection situation of press hardened parts using the 3MA non-destructive testing system. The FEM model is based on robust strategy calculation which manages the issues of geometry and the time multiscale, as well as the local nonlinear hysteresis behavior of ferromagnetic materials. 3MA simulations are performed at high level operating point in order to saturate the soft microscopic surface soft layer of press ...
Tópico(s): Microstructure and Mechanical Properties of Steels
2017 - American Institute of Physics | AIP Advances
Franco Magagnato, Martin Gabi,
In order to predict unsteady ¯ow ®elds one can use the Reynolds Averaged Navier-Stokes Equations (RANS) with a statistical turbulence model or Large Eddy Simulation (LES) in conjunction with a subgrid-scale model.Since the ¯ow ®eld in rotating machinery, internal combustion engines etc., is often strongly three-dimensional and unsteady, the calculation with LES and RANS are similar in terms of cpu-time providing the grid resolutions are similar.The turbulence models used with RANS have been designed in ...
Tópico(s): Fluid Dynamics and Vibration Analysis
2002 - Hindawi Publishing Corporation | International Journal of Rotating Machinery
Mary Dixon‐Woods, Richard Baker, Kathryn Charles, Jeremy Dawson, Gabi Jerzembek, Graham Martin, Imelda McCarthy, Martin McKee, Joel T. Minion, Piotr Ozierański, Janet Willars, Patricia Wilkie, Michael West,
Background Problems of quality and safety persist in health systems worldwide. We conducted a large research programme to examine culture and behaviour in the English National Health Service (NHS). Methods Mixed-methods study involving collection and triangulation of data from multiple sources, including interviews, surveys, ethnographic case studies, board minutes and publicly available datasets. We narratively synthesised data across the studies to produce a holistic picture and in this paper present ...
Tópico(s): Medical Malpractice and Liability Issues
2013 - BMJ | BMJ Quality & Safety
Leonora G Weil, Gabi Bin Nun, Martin McKee,
In 2011, a series of physician strikes in Israel followed eight months of unsuccessful negotiations with the government (Ministry of Health and the Ministry of Finance). Strikes by physicians may be a warning that all is not well in a health system and protestors have claimed that they signify a system failure. In contrast, others argue that strikes have been a feature of the Israeli health system from its inception and should not be a cause for alarm. This paper analyses the Israeli health system ...
Tópico(s): Healthcare cost, quality, practices
2013 - BioMed Central | Israel Journal of Health Policy Research
Elliot Rosenberg, Baruch Lev, Gabi Bin Nun, Martin McKee, Laura Rosen,
This article describes the development of a national health targeting initiative entitled ‘Healthy Israel 2020’ which was created to enhance the health and wellbeing of Israelis through a variety of health promotion and disease prevention interventions. This initiative builds upon the experience of two major worldwide targeting efforts, “Health People 2010” of the US and the World Health Organization's Health21’, as well as lessons learned from other countries. Important philosophical underpinnings ...
Tópico(s): School Health and Nursing Education
2008 - Elsevier BV | Public Health
Michaela Keuper, Stephan Sachs, Ellen Walheim, Lucia Berti, Bernhard Raedle, Daniel Tews, Pamela Fischer‐Posovszky, Martin Wabitsch, Martin Hrabĕ de Angelis, Gabi Kastenmüller, Matthias H. Tschöp, Martin Jastroch, Harald Staiger, Susanna M. Hofmann,
Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (MΦs), and recent data from mouse studies suggest that macrophages are modifiers of adipocyte energy metabolism and mitochondrial function. As mitochondrial dysfunction has been associated with obesity and the metabolic syndrome in humans, herein we aimed to delineate how human macrophages may affect energy metabolism of white adipocytes. Human adipose tissue gene expression analysis for markers ...
Tópico(s): Immune cells in cancer
2017 - Elsevier BV | Molecular Metabolism
James W. Lightfoot, Mohannad Dardiry, Ata Kalirad, Stefano Giaimo, Gabi Eberhardt, Hanh Witte, Martin Wilecki, Christian Rödelsperger, Arne Traulsen, Ralf J. Sommer,
Developmental plasticity influences cooperative versus competitive social action strategies in animals.
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2021 - American Association for the Advancement of Science | Science Advances
Stefani Parmentier, Michael Krämer, Swetlana Weller, Ulrich S. Schuler, Rainer Ordemann, Gabi Rall, Markus Schaich, Martin Bornhäuser, Gerhard Ehninger, Frank Kroschinsky,
Abstract Despite the increasing role of molecular markers, differential counts and morphology of hematopoietic cells in the bone marrow (BM) remain essential diagnostic criteria in hematological diseases. However, the respective reference values for BM myelogram commonly used came from small series with limited numbers of healthy individuals. We evaluated the myelograms of 236 healthy individuals who underwent unrelated bone marrow donation. Health check-ups were performed 4 weeks prior to harvest. ...
Tópico(s): Clinical Laboratory Practices and Quality Control
2020 - Springer Science+Business Media | Annals of Hematology
Richard Kraemer, Hans‐Jürgen Smith, Thomas Sigrist, Gabi Giger, Roland Keller, Martin Frey,
There are few studies comparing diagnostic accuracy of different lung function parameters evaluating dose–response characteristics of methacholine (MCH) challenge tests (MCT) as quantitative outcome of airway hyperreactivity (AHR) in asthmatic patients. The aim of this retrospectively analysis of our database (Clinic Barmelweid, Switzerland) was, to assess diagnostic accuracy of several lung function parameters quantitating AHR by dose–response characteristics. Changes in effective specific airway conductance ( ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2016 - BioMed Central | Respiratory Research
Benedikt Stoib, S. Filser, Julia Stötzel, Anton Greppmair, Nils Petermann, Hartmut Wiggers, Gabi Schierning, M. Stutzmann, Martin S. Brandt,
We review the Raman shift method as a non-destructive optical tool to investigate the thermal conductivity and demonstrate the possibility to map this quantity with a micrometer resolution by studying thin film and bulk materials for thermoelectric applications.In this method, a focused laser beam both thermally excites a sample and undergoes Raman scattering at the excitation spot.The temperature dependence of the phonon energies measured is used as a local thermometer.We discuss that the temperature ...
Tópico(s): Advanced Thermoelectric Materials and Devices
2014 - IOP Publishing | Semiconductor Science and Technology
S. Parmentier, Johannes Schetelig, Kerstin Lorenz, Michael Krämer, Robin Ireland, Ulrich S. Schuler, Rainer Ordemann, Gabi Rall, Markus Schaich, Martin Bornhäuser, G. Ehninger, Frank Kroschinsky,
According to WHO 2008 guidelines, the required percentage of cells manifesting dysplasia in the bone marrow to qualify as significant is 10% or over in one or more hematopoietic cell lineages, but this threshold is controversial. No 'normal' values have been established. Therefore, we investigated dyshematopoiesis in bone marrow aspirate squash preparations of 120 healthy bone marrow donors.Bone marrow squash slides of 120 healthy unrelated bone marrow donors were examined independently by 4 experienced ...
Tópico(s): Bone and Joint Diseases
2011 - Ferrata Storti Foundation | Haematologica
Nicolas Rüsch, Daniela Schulz, Gabi Valerius, Regina Steil, Martin Bohus, Christian Schmahl,
Disgust may be a key emotion and target for psychotherapeutic interventions in borderline personality disorder (BPD) and posttraumatic stress disorder (PTSD) at explicit and implicit-automatic levels. However, automatically activated disgust reactions in individuals with these disorders have not been studied. Disgust and its correlation with childhood abuse were assessed in women with BPD, but without PTSD; women with PTSD, but without BPD; women with BPD and PTSD; and healthy women. Disgust sensitivity, ...
Tópico(s): Emotions and Moral Behavior
2010 - Springer Science+Business Media | European Archives of Psychiatry and Clinical Neuroscience
Hedwig E. Deubzer, Barbara Busche, Gabi Rönndahl, Daniel Eikel, Martin Michaelis, Jindřich Činátl, Sandra Schulze, Heinz Nau, Olaf Witt,
The anti-epileptic drug valproic acid harbors anti-tumoral activity in solid and leukemic tumor cell models and is currently evaluated in clinical trials. However, the plasma trough concentrations obtained in patients by common anti-epileptic dose regimens are below concentrations required for exerting anti-tumor effects in vitro. Here, we describe the identification of three novel valproic acid derivatives with superior differentiation-inducing and anti-proliferative activities in K562 bcr/abl- ...
Tópico(s): HIV/AIDS drug development and treatment
2006 - Elsevier BV | Leukemia Research
Frank Birklein, Gabi Eisenbarth, Frank Erbguth, Martin Winterholler,
This study analyzes the suppression of sweat gland activity by botulinum toxin type B. We injected botulinum toxin type B (between 2 and 1000 mouse units subcutaneously) in the lateral side of both lower legs in 15 healthy volunteers. Sweat tests were carried out before botulinum toxin type B injections, and at 3 wk, 3 mo, and 6 mo. We studied focal anhidrosis by iodine–starch staining and by capacitance hygrometry after carbachol iontophoresis, according to the quantitative sudomotor axon reflex ...
Tópico(s): Myofascial pain diagnosis and treatment
2003 - Elsevier BV | Journal of Investigative Dermatology
Thomas Peters, Reinhard Sedlmeier, Heinrich Büssow, Fabian Runkel, Georg H. Lüers, Dirk Korthaus, Helmut Fuchs, Martin Hrabĕ de Angelis, Gabi Stumm, A Russ, Rebecca M. Porter, Martin Augustin, Thomas Franz,
Reduced coat 3 (Rco3) is a new spontaneous autosomal recessive mutation with defects in hair structure and progressive alopecia. Here we describe chromosomal mapping and molecular identification of the Rco3 mutation. The murine Rco3 locus maps to a 2-Mb interval on chromosome 15 encompassing the keratin type II gene cluster. Recently, mK6irs1 was described as a type II keratin expressed in Henle's and Huxley's layer of the murine inner root sheath. Genomic sequencing revealed a 10-bp deletion in ...
Tópico(s): Wnt/β-catenin signaling in development and cancer
2003 - Elsevier BV | Journal of Investigative Dermatology