Yasunori Oka, Takashi Kanbayashi, Takahiro Mezaki, Kazumi Iseki, Jun Matsubayashi, Gaku Murakami, Masaru Matsui, Tetsuo Shimizu, Hiroshi Shibasaki,
Tópico(s): Circadian rhythm and melatonin
2004 - Springer Science+Business Media | Journal of Neurology
Tomohisa Mori, Tomoe Kanbara, Masato Harumiya, Yoshiyuki Iwase, Masumoto Aki, Sachiko Komiya, Atsushi Nakamura, Masahiro Shibasaki, Toshiyuki Kanemasa, Gaku Sakaguchi, Tsutomu Suzuki,
The rewarding effects of μ-receptor agonists can be suppressed under several pain conditions. We recently showed that clinically used μ-receptor agonists possess efficacies for relieving the neuropathic pain induced by chemotherapeutic drug in rats; however, it is possible that the use of μ-receptor agonists may trigger the rewarding effects even under chemotherapeutic drug–induced neuropathic pain. Nevertheless, no information is available regarding whether μ-receptor agonists produce psychological ...
Tópico(s): Pain Management and Opioid Use
2014 - Elsevier BV | Journal of Pharmacological Sciences
Keiko Takasu, Koichi Ogawa, Atsushi Nakamura, Tomoe Kanbara, Hiroko Ono, Takako Tomii, Yasuhide Morioka, Minoru Hasegawa, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi,
We demonstrated previously that oxycodone has potent antinociceptive effects at supraspinal sites. In this study, we investigated changes in neuronal function and antinociceptive mechanisms of oxycodone at ventrolateral periaqueductal gray (VLPAG) neurons, which are a major site of opioid action, in a femur bone cancer (FBC) model with bone cancer-related pain.We characterized the supraspinal antinociceptive profiles of oxycodone and morphine on mechanical hypersensitivity in the FBC model. Based ...
Tópico(s): Neuropeptides and Animal Physiology
2014 - Wiley | British Journal of Pharmacology
Tomoe Kanbara, Atsushi Nakamura, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Toshiyuki Kanemasa,
It has begun to be understood that μ-opioid receptor (MOR) produces ligand-biased agonism, which contributes to differential physiological functions of MOR agonists. We previously demonstrated that in oxaliplatin-induced neuropathy in rats, morphine and oxycodone exhibited antinociceptive effects while antinociception of fentanyl was partial, and such different efficacies might result from the different level of Gi/o protein activation. Based on our background, to reveal further mechanism, we focused ...
Tópico(s): Cancer Treatment and Pharmacology
2014 - Elsevier BV | Neuroscience Letters
Atsushi Nakamura, Masahide Fujita, Hiroko Ono, Yoshie Hongo, Tomoe Kanbara, Koichi Ogawa, Yasuhide Morioka, Atsushi Nishiyori, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Gaku Sakaguchi, Akira Kato, Minoru Hasegawa,
Oxycodone and morphine are μ-opioid receptor agonists prescribed to control moderate-to-severe pain. Previous studies suggested that these opioids exhibit different analgesic profiles. We hypothesized that distinct mechanisms mediate the differential effects of these two opioids and investigated the role of G protein-gated inwardly rectifying potassium (K(IR)3 also known as GIRK) channels in their antinociceptive effects.Opioid-induced antinociceptive effects were assessed in mice, using the tail- ...
Tópico(s): Opioid Use Disorder Treatment
2013 - Wiley | British Journal of Pharmacology
Tomoe Kanbara, Atsushi Nakamura, Keiko Takasu, Koichi Ogawa, Masahiro Shibasaki, Tomohisa Mori, Tsutomu Suzuki, Minoru Hasegawa, Gaku Sakaguchi, Toshiyuki Kanemasa,
Oxaliplatin is a chemotherapeutic agent that induces chronic refractory neuropathy. To determine whether opioids effectively relieve this chronic neuropathy, we investigated the efficacies of morphine, oxycodone, and fentanyl, and the mechanisms underlying opioid antinociception, in oxaliplatin-induced neuropathy in rats. Rats exhibited significant mechanical allodynia following 2 weeks of chronic oxaliplatin administration. Within the range of doses that did not induce sedation and/or muscle rigidity, ...
Tópico(s): Plant-based Medicinal Research
2014 - Elsevier BV | Journal of Pharmacological Sciences
Shoji Terada, Gaku Izumi, Yukio Sato, Masayuki Takahashi, Mitsuru Tada, K. Kawase, Koji Shimotoku, Hitoshi Tamashiro, Nobuo Ozawa, T. Shibasaki, Chiyoko Sato, T. Nakadaira, Yuichi Iwase, Tatsuya Sasaoka, Tetsuo Urabe,
Abstract We developed a novel seamless tiling technology for full color AM‐OLED display. This technology is based on three items: 1) TAC‐based tiling structure, 2) High precision tiling process, 3) Brightness and color matching system. As a result, a 24‐inch panel, the largest OLED display ever reported, has been fabricated using 2×2 tiles with no apparent seams.
Tópico(s): Color Science and Applications
2003 - Wiley | SID Symposium Digest of Technical Papers
Toshiaki Nakajima, Akiko Haruyama, Taira Fukuda, Kentaro Minami, Suguru Hirose, Hiroko Yazawa, Takafumi Nakajima, Takaaki Hasegawa, Yoshiyuki Kitagawa, Syotaro Obi, Shu Inami, Gaku Oguri, Ikuko Shibasaki, Hirohisa Amano, Takuo Arikawa, Masashi Sakuma, Shichiro Abe, Hirotsugu Fukuda, Shigeru Toyoda,
Left atrial strain (LAS) measured by two-dimensional speckle tracking echocardiography (2DSTE) is considered to be a marker of LA structural remodeling, but it remains unsettled. We investigated the potential usefulness and clinical relevance of LAS to detect atrial remodeling including fibrosis by analyzing gene expression in cardiovascular surgery patients. Preoperative 2DSTE was performed in 131 patients (92 patients with sinus rhythm [SR] patients including paroxysmal AF [PAF], 39 atrial fibrillation [ ...
Tópico(s): Cardiac Valve Diseases and Treatments
2024 - Public Library of Science | PLoS ONE
Gaku Inaguma, Susumu Shibasaki, Masaya Nakauchi, Akiko Serizawa, Kenichi Nakamura, Shingo Akimoto, Tsuyoshi Tanaka, Kazuki Inaba, Ichiro Uyama, Koichi Suda,
Tópico(s): Multiple and Secondary Primary Cancers
2022 - Springer Science+Business Media | Surgical Endoscopy
Toshiaki Nakajima, Akiko Haruyama, Taira Fukuda, Kentaro Minami, Takafumi Nakajima, Takaaki Hasegawa, Seiko Tokoi, Syotaro Obi, Gaku Oguri, Masashi Sakuma, Ikuko Shibasaki, Hirotsugu Fukuda, Shigeru Toyoda,
Tópico(s): Acute Myocardial Infarction Research
2025 - Elsevier BV | IJC Heart & Vasculature