Jon Ashworth, Clare Spottiswoode, Andrew Pierce, Political Correspondent, Brian Collett, Andrew Pierce, Adrian Lee, Rob Hughes, Robert Napier, Chairman, Sue Pheasey, Lucy Fleming, Des Burkinshaw, Timothy A. Pickford, Richard Thomson, Isabel Carlisle, Richard Hobson, Robert Hiscox, Philip Howard, Carol Midgley, Hilary Finch, Jeremy Kingston, Joanna Bale, John Payne, Jeremy Laurance Health Correspondent, Hildur Helga Sigurdardottir and our Foreign Staff, Andrew Burrows, Lynne Truss, Carl Mortished, Morag Preston, Stuart Beadle, Norman De Mesqutta, Stewart Tendler, Crime Correspondent, Geoff Brown, Robert Sheehan, Bridge Correspondent, Arthur Leathley Political Correspondent, Alastair Campbell, Martin Fletcher, Valerie Elliott, John Redwood, Ann Scanlon, Peter Ball, Shirley English, David Pannic QC, Raymond Keene Chess Correspondent, J. C. Stott, Audrey Magee Ireland Correspondent, Thomas De Waal, Libby Purves, Peter Waymark, Michael Evans, Defence Correspondent, Alan Hamilton, Paul Sutton, Nicholas Watt, Michael Clark, Arpita Mogford, Jeremy Laurance, Health Correspondent, James Landale Political Reporter, Anatole Kaletsky, Janet Bush, Quentin Letts, Charles Bremner, Jonathan Prynn and Marianne Curphey, Philip Bassett, Industrial Editor, P. G. Anderson, A. G. Smith, Noel Fung, Nicholas Watt, Michael Evens and Richard Duce, Richard Cork, Philip Bassett, Paul Durman, M. S. Hancock, Michael Theodoulou, Nicholas Harling, Gary Slapper, Arthur Leathley, Political Correspondent, John Higgins, Raymond Keene, Peter Davalle, John Russell Taylor, Emma Wilkins, P. H. S, Sam Kiley and our Foreign Staff, Francis Bacon, Alice Thomson and James Landale, Bronwen Maddox, Michael Hammerson, PHS, Eric Reguly, Richard Owen, Oliver Holt, M. Al Fayed, Chairman, Roger Boyes, Nigel Hawkes, Science Editor, J. Sharp, Oliver August, Janet Bush Economics Correspondent, Philip Webster, Political Editor, Dalya Alberge, Rodney Hobson, Christopher Thomas, John Goodbody, Eileen McCabe, Rob Hughes, Football Correspondent, David Conn, Jason Nissé, Mel Webb, Kathryn Knight, Edward Leigh, Richard Evans Racing Correspondent, John Shaw, Scrivenor, Richard Duce and Alan Hamilton, Peter Riddell, Ben MacIntyre, Richard Beeston, Fraser Nelson, Robin Gray, Daniel Phelan, Editor, Evelyn Joll, Dr Thomas Stuttaford, Marianne Curphey, Frances Gibb Legal Correspondent, Mark Andrews, Stephen Dalton, Richard Morrison, Frances Gibb, David Powell, Vince Wright, David Maddock, Grace Bradberry Styler Editor, Steven Easton, David Hands, Rugby Correspondent, Christopher Irvine,
... ambassador for his trouble homeland, Croatia Picture Gallery Breen injury may force Irish shuffle Brazilians seeking safe ...
1996 - Gale Group | TDA
Tobias Weidner, Nicholas F. Breen, Gary P. Drobny, David G. Castner,
Sum frequency generation (SFG) vibrational spectroscopy has been employed in biomaterials research and protein adsorption studies with growing success in recent years. A number of studies focusing on understanding SFG spectra of proteins and peptides at different interfaces have laid the foundation for future, more complex studies. In many cases, a strong NH mode near 3300 cm−1 is observed in the SFG spectra, but the relationship of this mode to the peptide structure is uncertain, since it has been ...
Tópico(s): Enzyme Structure and Function
2009 - American Chemical Society | The Journal of Physical Chemistry B
Andrew Robson, Amanda Andrews, Mike Gerrard, Robert Cole, James Ducket, Fred Redwood, DJM, David Brown, Delilah Seale, Sarah Potter, Greg Hurst Political Correspondent, Gary Duncan, Professor Leighton Vaughan Williams, Simon Barnes, Peter Lansley, Philip Webster and Russell Jenkins, Mark Souster, Alexandra Frean Education Editor, Philip Howard, David Lyon, David Chater, Joanna Walters, Michael Binyon, Joanna Bale, James Ducker, Lorna Blackwood, Richard Hobson One-Day Cricket Correspondent, Phillip Wibester Political Editor, Patrick Kidd, John Bungey, Kevin Eason, Geoff Brown, Gerald Davies, Martin Fletcher, Pete Dorey, Rob Crilly, Tom Bawden, Steve Bird, Dominic Walsh, Dan Sabbagh Media Editor, Shirley English, Gary Jacob, Tim Reid, Toby Moore, Angela Jameson Industrial Correspondent, Dan Sabbagh, Richard Ford Home Correspondent, Anne Ashworth Property Editor, David Sharrock Ireland Correspondent, Jenny MacArthur, Phil Gordon, John McBride, Jenny Hodges, Ian MacKinnon, Alan Hamilton and Richard Beeston, Adam Sherwin Media Correspondent, Ron Lewis, Matt Dickinson Chief Football Correspondent, David Charter, Karen McVeigh, Edward Gorman, Angela Jameson, Susan Emmett, Russell Kempson, Paula Hawkins, Mary Gold, Daniel McGrory, Elizabeth, Oliver Kay, Colin Dexter, Gerard Baker, Nicole Swengley, Jane Wheatley, John Westerby, Pete Paphides, Gary Jacah, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Mark Souster and Christopher Irvine, Edward Gorman Motor Racing Correspondent, Emma Pomfret, Bernard Lagan, Marcus Binney, Raymond Keene, Lucia Adams, Christine Buckley, Liz Chang, Argus MacLeod Scottish Political Editor, Sean O'Neill, Jeremy Page, Chris Campling, Fran Yeoman, Bronwen Maddox, Helen Nugent, Damian Whitworth, Marcus Leroux, Gordon Musson, Mick Hume, Roger Boyes, Edward Reeves, Peter Dixon, Nick Hasell, Chris Salewicz, Paul Simons, Steve Jelbert, Anne Ashworth, Jack Hill, Mary Ann Sieghart, Philip Webster Political Editor, Rosie Bennett, Stephen Farell, Sandy Pratt, Jane Shilling, Ian Johns, Dominic Maxwell, Lord Lester, Ashling O'connor, Eric Smith, Neil Fisher, Peter Riddell, Ben MacIntyre, Michael Morgan, David Sinclair, Mark Henderson, Catherine Philp, Lewis Smith Environment Reporter, Gary Duncan and Gabriel Rozenberg, Baidwin and Anna Stroman, Martin Waller, Carl Mortished International Business Editor, Ashling O'Connor, Louise Cohen, Michael Bright, Angus Batey, Stuart Birch, Dr Thomas Stuttaford, Stephen Dalton, Tim Luckhurst, Richard Morrison, Neil Hunt, Adam Sherwin, Naomi Cleaver, Alan Lee Racing Correspondent, John Wainwright, Olav Bjortomt, Jenny Davey, Carolyn Asome Deputy Fashion Editor, Marcus Hampton, Joe Bolger, Christopher Irvine, Christine Buckley and Ashling O'Connor, John Merritt, Jayne Dowle,
... Barton Ireland pursue Robson decision Liverpool in court Breen cleared Dowie hits back Peace offer Argentina coach ...
2006 - Gale Group | TDA
Rita M. Breen, Gary Wasserman,
Decolonization in the Third World has most often been approached by tracing the ties of nationalist movements to the attainment of independence. This book attempts to revise the perspective. It presents a model of decolonization centring on the idea that the process was shaped by the reaction of colonial interests to the ascendancy of a nationalist elite. Rather than tracing the upward development of a nationalist movement, it traces the downward manipulation of that movement into a colonial system. ...
Tópico(s): African history and culture studies
1977 - Boston University | The International Journal of African Historical Studies
Giles Smith, Andrew Robson, Gabriele Marcotti, Widget Finn, Francis Beckett, Raymond Snoddy Media Editor, Parry Mitchell, Matthew Syed, Catherine Riley, DJM, Adam Sherwin Media Reporter, Greg Hurst Political Correspondent, Frances Gibb Legal Editor, Patrick Stirling-Aird, David Nickson, Laurie Arle, Robert Thicknesse, Andrew Carey, Paul Hoggart, Mark Souster, Arabella Beveridge, Stephen Bayley, Ivo Tennant, Ian Winrow, Michael Evans Defence Editor, Philip Howard, John R. Sharp, Christine Seib, David Chater, Michael Binyon, James Bone, James Ducker, Nic Hopkins, Elizabeth Judge, Graham Dunbar, Sam Marlowe, Kevin Eason, David Healer, Tom ADDISCOTT(Soil scientist), Peter Brown, Tony Holland, Valerie Elliott Countryside Editor, Pat Gibson, David McVay, Jennai Cox Fitness Editor, Kathryn Gyngell, Ian Lamont, Daniel McGrory, David Charter and Michael Evans, Joshua Jampol, Steve Bird, Ruth Gledhill, Debra Craine, James Doran Wall Street Correspondent, Gary Jacob, Alastair Hill, Patrick Marmion, Norman Harris, Jill Dupleix, Tim Reid, Dalya Alberge Arts Correspondent, Kate Figes, Phoebe Greenwood, Jenny MacArthur, Gerry Hanson, Michael Hamlyn, Sarah Butler and Sam Coates, Sheena Passfielf, Renée Bravo, David Hands, Charles Bremner, Ian MacKinnon, Ron Lewis, Mark Pougatch, Stefanie Marsh, Greg Hurst, Nicholas Wapshott, Matthew Pinsent, Caroline Merrell Banking Correspondent, Alan Davies, Russell Kempson, Tony Halpin Education Editor, Daniel McGrory, John Westerby, Michael Theodoulou, Mark Henderson Science Correspondent, Christopher Martin-Jenkins, Rob Wright, Geoffrey Dean, Gabriel Rozenberg, Neil Harman Tennis Correspondent, Christine Jones, Marcus Binney, Raymond Keene, John Ashworth, Matthew Pryor, Alison Godkin, Steve Coomber, Lea Paterson Economic Agenda, Cathy Harris, Richard Owen, Christopher Martin-Jenkins Chief Cricket Correspondent, Jack Gooch, John Carr, Clem Cecil, Roger Boyes, David Mattin, Peter Dixon, David Charter and Gabriel Rozenberg, Nick Kelly, Chirs Campling, Glynis Kozma, David Hands Rugby Correspondent, Tom Dart, Tony Cascarino, Nunzio Quacquerelli, Adam Fresco, Anna Frame, John Allison, William Rees-Mogg, Anne Ashworth, Jane Shilling, Geoff Parks, Tim Hames, Julie Burchill, Des Dearlove, Mike Rosewell, Michael Hill, Sylvia M. MacPherson, Michael Austin, Alan Lee, Walter Gammie, Anthony Loyd, Ben MacIntyre, Sarah Ebner, Richard Beeston, Ian Whittell, Philip Jobling, David Sinclair, Richard Miles, Lea Paterson, John Havard, Gary Duncan Economics Correspondent, James Jackson, Mark Baldwin, Sarah Butler, Daniel Rosenthal, Ashling O'Connor, Sarah Olney, Dr Thomas Stuttaford, Stephen Dalton, Vivien Cosh, Stephen Gardiner, Nicola Woolcock, Ben Sheppard, David Powell, Bill Edgar, Anna Horwood, Mark Venables, Randy Cohen, Sally Patten, Maureen Freely, Jenny Davey, Colin McQuillan, Richard Long (Second Secretary), Christopher Irvine,
... Burnley (1) 1 Little 11 Sunderland (1) 2 Breen 37, Kyle 66 Crewe Alexandra (0) 1 Ashton ...
2004 - Gale Group | TDA
Lloyd J. Nadeau, F-M Menn, A Breen, Gary S. Sayler,
Biotransformation of 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane (DDT) by Alcaligenes eutrophus A5 was demonstrated by analysis of ethyl acetate-extracted products from resting cell cultures. Gas chromatography-mass spectrometry characterization of the neutral extracts revealed two hydroxy-DDT intermediates (m/z = 370) with retention times at 19.55 and 19.80 min that shared identical mass spectra. This result suggested that the hydroxylations occurred at the ortho and meta positions on the aromatic ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
1994 - American Society for Microbiology | Applied and Environmental Microbiology
Issandr el Amrani, Andrew Robson, Alyn Shipton, Rosemary Righter, David Adams, Kenneth W. Cattermole, Andrew Pierce, DJM, John Ainsworth, Chief Executive, Adam Sherwin Media Reporter, Frances Gibb Legal Editor, Simon Barnes, Anne Woodham, Lea Paterson, James Moore And Gary Duncan, Richard Hobson, Steven Lynch, Nick Hawton, Ivo Tennant, Lisa Melton, Michael Evans Defence Editor, Philip Howard, Hilary Finch, Carol Midgley, Ian Gibson, Chair, David Roddan, General Secretary, David Chater, Tom Brake, Penny Wark, Nic Hopkins, Alison Kervin, Clive Davis, Chris Bowers, Elizabeth Judge, Sam Szlezinger, Peter Adams, Richard Eaton, Nick Szczepanik and Oliver Kay, Jeremy Whittle, Geoff Brown, Andrew Norfolk, John Thicknesse, Janie Darling, Tony de Launay, Valerie Elliott Countryside Editor, John Clarke, Stewart Tendler Crime Correspondent, Dumeetha Luthra, Jennai Cox Fitness Editor, Jack Malvern, Steve Bird, R. L. Black, Adam Sage and Rory Watson, Tim Reid, Dan Sabbagh, Libby Purves, Nadia Damouni, Alan Hamilton, Oliver Wright, Peter Nichols, Miranda Ingram, Valerie Elliott Consumer Editor, Vivian Labaton, Greg Hurst, David Charter, Angela Jameson, Daniel McGrory, Jerome Burne, Jill Sherman Whitehall Editor, Mark Henderson Science Correspondent, Christopher Martin-Jenkins, Simon de Bruxelles, Rob Wright, David Powell Athletics Correspondent, Raymond Keene, Roland Watson and Michael Binyon, Adam Sage, Dee Moss, Matthew Pryor, M. G. Sherlock, Greg Hurst Parliamentary Correspondent, Russell Hotten, Cathy Harris, Jonathan Edwards, Damaris Graham, Eugene Suggett, Christopher Martin-Jenkins Chief Cricket Correspondent, Paul Simons, John Kennedy, Dominic Kennedy, Melissa Kite Political Correspondent, Mel Webb, Cllve Davis, Craig Lord, Neil Hibbins, Matthew Parris, Maureen Paton, George Caulkin, Chris McGrath, J. G. Wishart, Alan Lee, Patience Wbeatcroft, Michael Gove, Michael Gouriet and Mark Harper, Stuart Bridge, Bob Woffinden, David Charter Chief Political Correspondent, Michael Dynes, Jane Czyzselska, Mark Henderson, Chris Ayres, James Jackson, Carl Mortished International Business Editor, Nigel Hawkes Health Editor, Laura Peek, Sarah Butler, Stephen Dalton, Paul Connolly, Frances Gibb, Tom Parker, Abigail Rayner, Matthew Connolly, Ashling O' Connor, Sally Patten, Tim Johnston, David Robertson, Colin McQuillan, Robin Shepherd, Christopher Irvine, Joan Smith, David Lister Ireland Correspondent,
... spotlight after wife is arrested Cycling Roeder attracts Breen to West Ham Football Wigan searching for spirit ...
2002 - Gale Group | TDA
Carolyn M. Phillips, Taiowa A. Montgomery, Peter C. Breen, Gary Ruvkun,
RNA silencing can be initiated by endogenous or exogenously delivered siRNAs. In Caenorhabditis elegans, RNA silencing guided by primary siRNAs is inefficient and therefore requires an siRNA amplification step involving RNA-dependent RNA polymerases (RdRPs). Many factors involved in RNA silencing localize to protein- and RNA-rich nuclear pore-associated P granules in the germline, where they are thought to surveil mRNAs as they exit the nucleus. Mutator class genes are required for siRNA-mediated ...
Tópico(s): RNA Research and Splicing
2012 - Cold Spring Harbor Laboratory Press | Genes & Development
Andrew Robson, Amanda Andrews, Simon Barnes Chief Sports Writer, Phil Yates, Gabriele Marcotti, Ray Flint, Rosemary Righter, Alexi Mostrous, Rev Charles Taylor Dean of Peterbough, Andrew Billen, Matthew Syed, Catherine Riley, David Brown, Frances Gibb Legal Editor, Simon Barnes, Robin Pagnamenta Energy and Environment Editor, Peter Lansley, Ashling O'Connor Olympics Correspondent, Hannah Devlin, Mark Souster, David Rhys Jones, Michael Evans Defence Editor, Alex Wade, Claude Makelele, Canon David Godwin, Hilary Finch, David Chater, Jeremy Kingston, James Ducker, Richard Hobson One-Day Cricket Correspondent, Elizabeth Judge, Carl Mortished, Patrick Kidd, James Hider, Geoff Brown, Lucy Bannerman, Gerald Davies, Martin Samuel Chief Football Correspondent, Sam Banik, Joe Joseph, Robin Pagnamenta, Martin Fletcher, Frieda Hughes, Siobhan Kennedy, Ruth Gledhill, Debra Craine, Gary Jacob, Adrian Bingham, Ian H. Lane, Peter Croggon, Ruth Gledhill Religion Correspondent, Dalya Alberge Arts Correspondent, Dan Sabbagh, Michael Stennett, Father Timothy Radcliffe, Tony Phillips, Patricia Stephens, Anatole Kaletsky, The Right Rev Keith Sinclair, Rear-Admiral Rees Ward Director-General, David Hands, Lisa Armstrong Fashion Editor, São Paulo, Simon de Bruxelles and Fiona Hamilton, Tim Teeman, Derwent May, Rev Dr C. Campbell-Jack Glasgow, Russell Kempson, Suzy Jagger, Oliver Kay, Mark Henderson Science Editor, Ryan Giggs, Rick Broadbent, Kate Allen Director, Tom Baldwin, Ben Quinn, James Rossiter, John Hopkins, Rob Wright, Neil Harman Tennis Correspondent, Martin Samuel, Raymond Keene, Adam Sage, Sean O'Neill Crime and Security Editor, Christine Buckley, Lewis Smith, Matthew Pryor, Matt Hughes, David Lister Scottish Correspondent, Sean O'Neill, Dr Tanya Byron, David Owen, Jeremy Page, Chris Campling, Huy Selby-Lowndes, Marcus Leroux, Barbara Stocking Chief Executive, Peter Dixon, Dr Elizabeth Phillips, Carolyn Asome, Owen Slot Chief Sports Reporter, David Hands Rugby Correspondent, Tom Dart, Tony Cascarino, Paul Simons, Philippa Russell, William Rees-Mogg, John Abrami, Philip Webster Political Editor, Tim Hames, Graham Chase, Thomas Catán, Anjana Ahuja, George Caulkin, Sonia Verma, Tony Hannan, Russell Jenkins, Caitlin Moran, Alan Lee, Walter Gammie, Peter Riddell, Ian Neilson, Father Paul Graham, David James, Tom Hennigan, Philip Webster, David Sinclair, Mark Henderson, Robert Easton, James Jackson, Patrick Foster, Nigel Hawkes Health Editor, Ashling O'Connor, Benedict Nightingale, Paul Larter, Rick Broadbent Athletics Correspondent, Stephen Dalton, Henry Smith Director, Leo Lewis, Bill Edgar, Frances Gibb, Alyson Rudd, Alan Lee Racing Correspondent, Olav Bjortomt, David Robertson, Ganesh Lall, Christopher Irvine,
... Triumph on the new frontier Senior service for Breen after omission from junior choice Bowls Leading final ...
2008 - Gale Group | TDA
Ying Liu, Buck S. Samuel, Peter C. Breen, Gary Ruvkun,
Mitochondrial function is challenged by toxic by-products of metabolism as well as by pathogen attack. Caenorhabditis elegans normally responds to mitochondrial dysfunction with activation of mitochondrial-repair, drug-detoxification and pathogen-response pathways. Here, from a genome-wide RNA interference (RNAi) screen, we identified 45 C. elegans genes that are required to upregulate detoxification, pathogen-response and mitochondrial-repair pathways after inhibition of mitochondrial function by ...
Tópico(s): Sphingolipid Metabolism and Signaling
2014 - Nature Portfolio | Nature
Jan Masters, Jonathan Northcroft, Waldemar Januszczak, Ivan Armstrong, Georgina Harland, Matthew Wall, Jim, Aa Gill, Barbara Hall, Nigel Botherway, Michael O'Hare, Helen Kirwan-Taylor, James Clark, Nicholas Rufford, Robert Wilson, Rob Hughes, John Peter, V S, Dan Pearson, Amanda Ursell, Emma Moore, Chrissy Hey, Pavlos Plessas, Jonathan Miller, Andy Packer, Donna Leon, Lesley White, Jane Mulkerrins, J D, Susan d'Arcy, Max Glaskin, Frank Whitford, Ivo Tennant, Kirstle Hamilton, Kathryn Cooper, David Miro Benda, David Smith, Philip Matthews, Tim Richards, Kira Cocharane, Rory Godson, David Cracknell Political Editor, E Bell, Andrew Sullivan, Chery Markosky, Guy Dennis, Michael Paterson, Lynne Truss, Sue Leonard, Joseph Dunn, Tony Allen-Mills, Simon Wilde, Martin James, Anthony Sattin, Phil Smith, Robert Winnett, Sir Alex Ferguson, Irwin Stelzer, Matt Rudd, Kate Munson, Peter Wilson, Robert Hewison, Martin Anscombe, Patricia Bridger, David Dougill, John Jordan, Phil Baty, Frank Graham, Kine Burgess, Philip Kingsley, Sophie Gilbert, John Timpson, Geraldine Hackett, Robert Peston, Yeslam Binladin, Jonathon Carr-Brown, Margarette Driscoll, Alasdair Reid, Hugh Canning, Colin Mehigan, Jeremy Clarkson, Peter Jackson, Edward Porter, Victoria Segal, Louise Taylor, James Clark Defence Correspondent, Mini Grey, John O'Donnell, Lynn Cochrane, Peter Oliver, Ebon Black Chief Political Correspondent, Adam Nathan, Nick Gardner, Michael Sean Gillard, Richard Bard, Matthew Collings, Paul Donovan, Alastair Hendy, Nigella Lawson, Angela Newing, Michael Cole, Lucinda Kemeny, Jasper Gerard, Hugh McILVANNEY, Paul Driver, Boris Schapiro, Ann McFerran, Bill Baily, Joa Swain, Richard Brooks, Caroline Scott, Ian Hawkey, Shelley Von Strunckel, Christopher Morgan, David Leppard, Iqbal Qasim, Paul Durman, Mark Edwards, Kirstie Hamilton, Sarah Gracie, Dan van der Vat The Guardian, Kerry Kousiounis, David Lawrenson, Susan Clark, Eben Black Chief Political Correspondent, Flossle McMullan, Mike Mogano, Victoria O'Brien, Tony Woolf, Alan Combes, Raymond Keene, A W Jenkins, David Cracknell, Cosmo Landesman, Grant R Goss, Robbie Hudson, Anne Craddock, Michael Cull, Colin Smith, Diana Wright, Greg Hadfield, Andy Knott, Peter Montseey, Stephen Jones, Dominic O'Connell, Barry Flatman, John Herlow, Nick Cain, Richard Evans, Thomas Sowell, Domonic O'Connell, Michael Wright, Client Levy, Natalie Graham, Rod Baker, Kate Rew, M J, Tim Moorey, Amunda Craig, Ken Clark, Rob Ryan, Kethy Brewis, Fiona Terry, Mac Selkirk, Jack Grimston, Lois Rogers Medical Correspondent, Briyan Appleyard, Chris Dobson, Silmon Wllde, Loulse Taylor, Stephen Armstrong, Richard Woods, Roland White, Gerald Cass, Rory Godson Business Editor, William Rees-Mogg, Aileen McLeish, S K, Wayne Bodkin, Nick Hanna, Ronald White, Brian Glanvile, Ron clarke, Richard Rae, Ray Hutton, James Hughes, Craig Lord, Martin Ivens, Frank Fitzgibbon, Ruth Walden, Sea Newsom, John Crossland, Peter Mayle, Richard Brooka Arts Editor, Gary Robertson, Godfrey Smith, Kirstle Hamilton City Editor, John Urbanek, Barry Collins, Domlnic O'Connel, Gillian Wilmot, Hilary Lowe, John Waples, Sasha Slater, John small, Brian Glanville, Hunter Davis, John Carey, Kenneth J Carter, David Salmon, Stephanie Cook, Winner's Dinners, Nick Fielding, Joaanna Simon, Claudia Croft, Will Iredale, Jonathan Calvert, Mathew Cambell, Jane Goldsmith, Peter Goodman, Alexis Glies, Tom Walker Diplomatic Correspondent, Sally Kinnes, Naomi Caine, David Wickers, Joe Cawley, Harry Hindle, Debbie Hollis, Lois Rorere Medical correspondent, Mark Hodson, Nick Calm, Graham Norwood, Jonathan Futrell, Ray Perry, Rupert Steiner, Dr John Fox, David Budworth, Charmian Edgerton, Marcia MacLeod, Tony Perrottet, Margaret Holder, Cosmo Landersman, David Walsh Sports writer of the year, Mrs Mills, John Alzlewood, Simon Crerar, Sarah Baxter, Peter Roebuck, Matthew Goodman, Steve Grant, Barry Newcombe, Dominic Rushe, Richard Lewis, Sian Griffiths, Karen Robinson, Peter Stanford,
... the season jolly Alone it stands By John Breen It's all around you His majesty revealed ...
2001 - Gale Group | Sunday Times HA GDA
Davide Prezzi, K. Owczarczyk, Paul Bassett, Muhammad Siddique, David J. Breen, Gary Cook, Vicky Goh,
To investigate whether adaptive statistical iterative reconstruction (ASIR), a hybrid iterative CT image reconstruction algorithm, affects radiomics feature quantification in primary colorectal cancer compared to filtered back projection. Additionally, to establish whether radiomics from single-slice analysis undergo greater change than those from multi-slice analysis. Following review board approval, contrast-enhanced CT studies from 32 prospective primary colorectal cancer patients were reconstructed ...
Tópico(s): Advanced X-ray and CT Imaging
2019 - Springer Science+Business Media | European Radiology
Jon Ashworth, Raymond Snoddy Media Editor, Helen Johnstone, Joanna Hunter, Nick Nuttall, Robert Cole, Sally Brock, James Moore, Adrian Lee, Alexandra Frean and Adam Sherwin, Grace Bradberry, Paul Hoggart, Jonathan Lennie, Michael Evans Defence Editor, Philip Howard, A. D. Arsheni, Ian Murray, Chris Ayres, Media Business Correspondent, Joanna Bale, James Bone, Alison Kervin, Elizabeth Judge, Carl Mortished, Graham Stewart, Barbara Ellen, Richard Eaton, James Landale, Political Correspondent, Nick Nuttall, Environment Correspondent, Gordon Munday, Tony Patrick, Roland Watson, Chief Political Correspondent, Kevin Eason, Jason Allardyce and James Landale, Raymond Snoddy, William Thomson Chairman, John Grint, Jasper Gibson, Giles Coren, Antonia Senior, David McVay, Cornelius Lysaght, Dominic Walsh, Peter Nicholls, Shirley English, Gary Jacob, Raymond Keene Chess Correspondent, Dalya Alberge Arts Correspondent, Godfrey Barker, Mark Inglefield, Ian Murray, Medical Correspondent, David Robinson and Michael Mulvihill, Alice Lagnado, Richard Beeston and Michael Hartnack, Mike Bradley, Jason Allardyce, Scottish Political Reporter, Charles Bremner, Michael Leapman, Peter Barnard, Matthew Bayley, Tim Teeman, Caroline Merrell Banking Correspondent, Jim Symington, Birgitte Hygen, Russell Kempson, John MacKenzie, Daniel McGrory, Paul Armstrong, Richard Cork, Paul Durman, Paul McCann, Michael Durham, Jill Sherman Whitehall Editor, Julian Ma, Geoffrey Dean, Celia Brayfield, Stephen Wood, Dalya Alberge, Arts Correspondent, Philip Hebbert, Christine Buckley and Alasdair Murray, Adam Jones, Raymond Keene, Adam Sage, Clive Mathieson, Paul Wilkinson, Stefano Hatfield, Bulent Gokay, Arthur Leathley Transport Correspondent, Christopher Walker Chief Ireland Correspondent, Deborah Brett, Melissa Kite, Cathy Harris, Jason Allardyce and Stewart Tendler, Damian Whitworth, Roger Boyes, Nick Hasell, Ben Pimlott, Steve Bailey, Jill Curtis, Philip Webster, Political Editor, Hettie Judah, P. D. Doherty, John Linford, John Allison, Richard Duce, Alastair Vize, Nick Szczepanik, Giles Whittell, Nick Nuttall, Technology Correspondent, Martin Desvaux, Simon De Bruxelles, Jane Shilling, Mel Webb, Kevin McCarra, Matthew Parris, Alasdair Reid and David Hands, Chris McGrath, Russell Jenkins, Caitlin Moran, Alan Lee, Peter Riddell, Ben MacIntyre, Richard Beeston, Richard Beeston Diplomatic Editor, Michael Dynes, David Sinclair, Fraser Nelson, Simon Jenkins, Martin Waller, Susan Emmett and Richard Miles, Pugh and Way, Benedict Nightingale, Alexandra Frean, Social Affairs Correspondent, Christine Buckley and Arthur Leathley, Dr Thomas Stuttaford, David Richardson, Helen Rumbelow, Medical Reporter, Adam Sherwin, Alasdair Murray, Tony Barlow, Fraser Nelson Retail Correspondent, David Hands, Rugby Correspondent, Lea Paterson, Economics Correspondent, John Rowe Townsend, Trevor Phillips,
... Life at the Races Keep faith in Nathan Breen courts Mass appeal Johnson booked for Looks Like ...
2000 - Gale Group | TDA
Nicolas J. Lehrbach, Peter C. Breen, Gary Ruvkun,
Tópico(s): Autophagy in Disease and Therapy
2019 - Cell Press | Cell
Andrew Robson, Dr Thomas Stuttaford Medical Briefing, Nadia Comaneci, Louis Blom-Cooper, Raymond Snoddy Media Editor, Matthew Bannister, David Adams, Helen Studd, Robert Cole, Mike Spence, James Moore, Zahid Hussain, Sarah Potter, Frances Gibb Legal Editor, Clive Sherwood, Magnus Linklater, Anne Woodham, Nicholas BETHELLl, Penny Lewis and Jon Robins, David Rhys Jones, Linda Tsang, Michael Evans Defence Editor, Philip Howard, John Fitzpatrick, Hilary Finch, David Chater, Michael Binyon, David Cooke, Bronwen Maddox Foreign Editor, Gabrielle Starkey, Carl Mortished, Deborah Jeff, James Eve, Geoff Brown, Sam Lister, Joe Joseph, Andrew Norfolk, Giles Coren, David Charter and Glen Owen, Ysenda Maxtone Graham, P. L. Lantos, Geoff Brawn, Gary Jacob, Dr Jane Collins, Tim Reid, Libby Purves, Richard Ford Home Correspondent, Philip Webster and Richard Beeston, Oliver Kay and Russell Kempson, Stephen Farrell, Oliver Wright, Heather Nicholson, Roland Watson, Keith Pike, Opera, Susan Breen, Mark Giles, Terry Wogan, Nicholas Wapshott, Caroline Merrell Banking Correspondent, Edward Fennell, David Lister, Fiona Manisty, Matt Dickinson Football Correspondent, Barry Millington, Steuart & Francis, Simon de Bruxelles, John Hopkins Golf Correspondent, Rob Wright, Jonathan Sumption, QC, Benn's, Josephine Hayes, Raymond Keene, Clive Mathieson, Lewis Stuart and David Hands, Tim Reld and Laura Peek, Jim Watt, G. A. Khoury, David Ilderton, Nigel Cliff, Greg Hurst Parliamentary Correspondent, Oliver Holt, David Charter and Gary Duncan, Janet L. Nelson, Mick Hume, David Pannick QC, Kevin M. Pelham, Dalya Alberge, David Hands Rugby Correspondent, Jessica Douglas-Home, John Allison, Nick Szczepanik, John Goodbody, John Cooper, James Doran, Melissa Kite Political Correspondent, Christopher Walker, Richard Clayton and Richard Curtin, Conor Ryan, Gary Kitchen (Director), Matthew Parris, Jonathan Clark, Caitlin Moran, Dearbail Jordan, Anthony Loyd, Peter Riddell, Lea Paterson Economics Editor, Aidan Robertson, Richard Cork And Joanna Hunter, Alison Beckett and Daniel McGrory, Graham Searjeant, Lea Paterson, Gary Duncan Economics Correspondent, Martin Waller, Chris Ayres, James Jackson, Carl Mortished International Business Editor, McLibel, Dr Thomas Stuttaford, Stephen Dalton, Richard Morrison, Frances Gibb, Vince Wright, Richard Beeston and Philip Webster, Alan Lee Racing Correspondent, Richard Ford and Valerie Elliott, Anthony Howard, Michael Brown, Patience Wheatcroft, Christopher Irvine, David Lister Ireland Correspondent,
Why Harry Potter Reveals the Best and Worst of… Mrs Miniver's secret Life: the first domestic… Police alert after animal rights bomber dies on hunger ...
2001 - Gale Group | TDA
Kai Mao, Peter C. Breen, Gary Ruvkun,
RNA interference (RNAi) is an antiviral pathway common to many eukaryotes that detects and cleaves foreign nucleic acids. In mammals, mitochondrially localized proteins such as mitochondrial antiviral signaling (MAVS), retinoic acid-inducible gene I (RIG-I), and melanoma differentiation-associated protein 5 (MDA5) mediate antiviral responses. Here, we report that mitochondrial dysfunction in Caenorhabditis elegans activates RNAi-directed silencing via induction of a pathway homologous to the mammalian ...
Tópico(s): CRISPR and Genetic Engineering
2020 - Public Library of Science | PLoS Biology
Giles Smith, Andrew Robson, Gabriele Marcotti, Jon White, Phil Yates, Jim Lyon, Rosemary Righter, Jon Ashworth, Catherine Philip, Matthew Syed, Kate Hammond, Alexandra Frean, Gary Duncan, Peter Lansley, Robert Thicknesse, Paul Hoggart, David Rhys Jones, Jim Quinn, Andrew Robinson, David Blunkett, Archie Thomson, , Alex Fynn and Kevin Whitcher, Philip Howard, Carol Midgley, Tara Holmes, David Chater, James Ducker, John Habgood, Nic Hopkins, Alison Kervin, Rob Sixsmith, Alexandra Frean Social Affairs Correspondent, Kevin Eason, Martin E. Simons, Gerald Davies, Sam Lister, Giles Coren, David Sharrock, Antonia Senior, Valerie Elliott Countryside Editor, David McVay, Joyce Glasser, London Nw3, Stewart Tendler Crime Correspondent, Jennai Cox Fitness Editor, Steve Bird, Debra Craine, Gary Jacob, Patrick Marmion, Tim Reid, Rosemary Bennett, Angela Jameson Industrial Correspondent, Mark Serwotka, General Secretary, Roger Blears, Phoebe Greenwood, Tom Foulkes, Director General, Robin Young, Stephen Farrell, Anselm Kuhn, Phil Gordon, David Hands, Charles Bremner, Ron Lewis, Stefanie Marsh, David Charter, Nicholas Wapshott, Pat Hodgson, Barry Daniels, Hugo Rifkind, Alison Davis, Blandford forum, Alan Davies, Russell Kempson, Alistair J. Sinclair, Christine Selb, Ronan McGreevy, Peter Bainbridge, Lisa Armstrong, Rick Broadbent, Tom Baldwin, Stephen Burgen, Paul Speakman, John Hopkins, Jon Ashworth and Stefanie Marsh, Ann Treneman, Michael R. Cavaghan-Pack, John Hopkins Golf Correspondent, Aki Rihlahti, Michael Brookers, Raymond Keene, Christine Buckley, Sean MacAulay, Matt Dickinson, Brain Shelley, Simon Hart, Rosemary Bennett Deputy Political Editor, Greg Hurst Parliamentary Correspondent, Lawrence Breen, Peta Bee, Abigall Rayner, John A. S. Flynn, Chris Campling, Cathy Harris, Richard Owen, Tim Spanton, Mick Hume, poll detalls, Marc Padgett, Jane Feinmann, Stewart Tendler, David Hands Rugby Correspondent, Aidan Sherry, Tony Cascarino, Tom Dart, Paul Simons, Anna Frame, Michelle Henery, William Rees-Mogg, John Goodbody, Nick Szczepanik, Mary Ann Sieghart, Anthony Senior, Philip Webster Political Editor, David Pinless, Tim Hames, Jeremy Cross, Chris McGrath, George Caulkin, Burham Wazir, Walter Gammie, Peter Riddell, Mrs Dippy, Ben Webster, Tom Hennigan, Richard Miles, Lea Paterson, Lewis Stuart, John Locke, Bristol, Michael Horsnell, Lisa Verrico, Guy Herbert, Christopher Irvine, Carl Mortished International Business Editor, Mark Baldwin, Nigel Hawkes Health Editor, Jill Duplex, Glenn Renshaw, Dennis Rutherford, John Chambers, Ian Parkin, Dr Thomas Stuttaford, Stephen Dalton, Richard Morrison, Paul Connolly, Alyson Rudd, Bill Edgar, Adam Sherwin, Mark Venables, Matthew Connolly, Randy Cohen, Alan Lee Racing Correspondent, Richard Laming, Philip Pank,
Blair still in trouble Iraq vote reprieve New Labour in a spin Win a Superb Trip to the Rugby World Cup -… Beckham: my sore foot and those late nights The ...
2003 - Gale Group | TDA
Kai Mao, Peter C. Breen, Gary Ruvkun,
Surveillance of Caenorhabditis elegans mitochondrial status is coupled to defense responses such as drug detoxification, immunity, antiviral RNA interference (RNAi), and regulation of life span. A cytochrome p540 detoxification gene, cyp-14A4 , is specifically activated by mitochondrial dysfunction. The nuclear hormone receptor NHR-45 and the transcriptional Mediator component MDT-15/MED15 are required for the transcriptional activation of cyp-14A4 by mitochondrial mutations, gene inactivations, or ...
Tópico(s): DNA Repair Mechanisms
2022 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Andrew Lambirth, Mark Skipworth Consumer Affairs Correspondent, Frank Muir, Diana Lamplugh, Paul Nelson, Richard Ellis, Libby Coleman, John Davison, Jon Swain, Grace Bradberry, Rob Hughes, John Peter, Andrew Grice Political Correspondent, Mark Reason, Eric Dymock, Tel Aviv, Lesley White, Nick Kemp, Andrew Hogg Middle East Correspondent, Stephen Bayley, Graham Rose, Diana Wright Personal Finance Editor, Frank Abel, Barry Hyman Head of Media Relations, Sally Payne, Robert Burchfield, David Smith, Humphrey Carpenter, Credit Suisse, Sunnie Mann, I Leavey, N Kurti, Gillian Hall, Andrew Lloyd Webber, Charles Hymas, Jason Tomas, Edward Welsh, Jamie Bethell, Princess Margaret, Geordie Greig, Tony Allen-Mills, Patrick Stoddart, Susan Marling, Caviar Kaspia, Iain Johnstone, David Brierley, Cheryle Berry, Ivan Fallon, Mark Ottaway, Deryk Brown, Robert Hewison, Cliff Temple, Harvey Porlock, Drew, Hugh Canning, Margarette Driscoll, Colin Dryden, J Stephen, Peter Kemp, John Melmoth, Norman Willis, Geoff Whitten, Robert Harris, Jozef Garlinski, Caroline Lees, Giorgio Armani, Paddy Ashdown, Geoffrey Breen, George Perry, Sue Mott, Robin Marlar, Mark Skipworth, Phillips, Chris Grant, Christine Toomey, Bernard Cafferty, Brian Moynahan, Fiona Walsh Deputy City Editor, Polly Samson's, Paul Donovan, Derek Picot, R Street, Eurl Spencer, Jeff Randall, Jasper Gerard, Paul Driver, P Logan, Boris Schapiro, David Hughes, Richard Cork, Tim Rayment, Richard North, Peter Plant, John Walker, Rufus Olins, Michael Durham, David Lawrenson, Robbie Polley, Chris Patten, Christopher Lloyd, John Karter, Bernard Shaw, Barbara Amiel, Malcolm Winton, Marie Colvin, Greg Hadfield, Craig Brown, Diana Wright, Dr G Stephen, Francis Bacon, Stephen Jones, Sean Wood, David Owen, Harry Mullan, Clive Barda, Gary Cook, Richard Palmer, Nick Hornby, Digby Anderson, Andrew Grice, Frank Allaum, Tony Husband, Martin Searby, Rob Ryan, Ian Schagen, Bryan Appleyard, H Hughes, Russell Miller, Steve Bright, Ian Glover-James, Clive Everton, Garth Alexander, John McEven, Anita Roddick, Dougal Hutchison, Maurice Chittenden, Mitchell Symons, David Hughes Chief Political Correspondent, Andrew Lorenz Business Editor, Simon Channon, Rebecca Fowler, Sussan d'Arcy, Michael Jones Political Editor, Lesley Kenadall, David Hunn, James Blitz, Andrew Yates, Clare Medwin, Susan Raven, D J Taylor, Mihir Bose, Alexander Yakovlev, Godfrey Smith, Michael Austin, Hugh Fearnley-Whittingstall, Ed McHenry, Michael Lewis, Matthew Campbell, Brian Glanville, Stan Levenson, John Carey, Norman Macrae, Chris Dighton, Mark Bonham-Carter, Anne Muller, Godfrey Golzen, Lauren St John, Tony Moss, Deirdre Fernand, Roy Jenkins, Andrew Lorenz, John Furbisher, Roy Isacowitz, David Wickers, Ian Weekley, Stephen Spender, Tiffen Rosen, Michael Holroyd, Bill Hamilton, Valerie Grove, Chris Lightbown, Jeff Randall City Editor, Vince Wright, Paula Reed, Andrew Davidson, Margaret Park, Hugh Pearman, Steve Speller, Jim Kelly, David Smith Economics Editor, Penny Perrick, Tony Hetherington, Anthony Howard, Charles Kennedy, Joanna Simon, James Dalrymple, Nigel Dempster, Iain Jenkins, David Owens, Christne Deverell,
Greek tycoon gives secret £2m to Tory party Ministers to target 6-year-olds in bid to fight lawlessness 'Potential criminals' to be identified at early ...
1991 - Gale Group | Sunday Times HA GDA
Charles A. Pettigrew, A Breen, C Corcoran, Gary S. Sayler,
Comparative studies were performed to investigate the contribution of microbial consortia, individual microbial populations, and specific plasmids to chlorinated biphenyl biodegradation among microbial communities from a polychlorinated biphenyl-contaminated freshwater environment. A bacterial consortium, designated LPS10, was shown to mineralize 4-chlorobiphenyl (4CB) and dehalogenate 4,4'-dichlorobiphenyl. The LPS10 consortium involved three isolates: Pseudomonas testosteroni (LPS10A), which mediated ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
1990 - American Society for Microbiology | Applied and Environmental Microbiology
Robert J. Steffan, A Breen, Robert Atlas, Gary S. Sayler,
Several gene probe methods were used to monitor specific microbial populations in freshwater microcosms. Detection methods included nonselective plating – colony hybridization, selective plating – colony hybridization, most probable number – filter hybridization, and community DNA extraction – dot blot hybridization. Tests were conducted in freshwater microcosms inoculated with a 4-chlorobiphenyl degrading Alcaligenes A5 or a 2,4,5-trichlorophenoxyacetic acid degrading Pseudomonas cepacia AC1100. Colony ...
Tópico(s): Water Treatment and Disinfection
1989 - Canadian Science Publishing | Canadian Journal of Microbiology
Adam Banks, Gary F. Breen, Darren Caine, John Carey, Christopher Drake, Michael A. Forth, Asa Gladwin, Simone Guelfi, Jerome F. Hayes, Paolo Maragni, David O. Morgan, P. Oxley, Alcide Perboni, Matthew E. Popkin, Fiona Rawlinson, G. A. C LE ROUX,
A synthetic route amenable to large-scale synthesis of the glycine antagonist (2R,4E)-7-chloro-4-(2-oxo-1-phenyl-pyyrrolidin-3-ylidene)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid, (2R,3R,4R,5S)-6-(methylamino)hexane-1,2,3,4,5-penta-ol 12 is presented. The route consists of four stages of chemistry. Stage 1 starts from 5-chloro-2-iodoaniline hydrochloride and is a three-step telescoped stage consisting of an imine formation with ethyl glyoxalate, Mannich reaction using vinyloxytrimethylsilane, and ...
Tópico(s): Asymmetric Synthesis and Catalysis
2009 - American Chemical Society | Organic Process Research & Development
Richard J. Atkins, Adam Banks, Richard K. Bellingham, Gary F. Breen, John Carey, Stephen K. Etridge, Jerome F. Hayes, Nigel Hussain, David O. Morgan, P. Oxley, Stephen C. Passey, Timothy C. Walsgrove, Andrew S. Wells,
The process development to the manufacturing route to (2S)-7-([4,4'-bipiperidin]-1-ylcarbonyl)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid hydrochloride (SB-214857-A, lotrafiban) is described. The starting point is the previously reported intermediate (2RS)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester. The first stage is a lipase-catalysed resolution of the racemic ester to (2S)-2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2- ...
Tópico(s): Neuropeptides and Animal Physiology
2003 - American Chemical Society | Organic Process Research & Development
Ian P. Andrews, Richard J. Atkins, Gary F. Breen, John Carey, Michael A. Forth, David O. Morgan, Amin Shamji, Andrew C. Share, Stephen A. Smith, Timothy C. Walsgrove, Andrew S. Wells,
The development of an efficient manufacturing route to 2,3,4,5-tetrahydro-4-methyl-3-oxo-1H-1,4-benzodiazepine-2-acetic acid methyl ester SB-235349, a key intermediate in the synthesis of lotrafiban is described. The synthesis starts with 2-nitrobenzyl alcohol which is mesylated, reacted with methylamine and then dimethylacetylene dicarboxylate followed by reduction of the nitro group. Treatment of the resultant aniline with acid gives an intermediate quinazoline which rearranges on treatment with ...
Tópico(s): Quinazolinone synthesis and applications
2003 - American Chemical Society | Organic Process Research & Development
Michael E. Baker, Barbara Ruggeri, Leslee Sprague, Colleen Eckhardt-Ludka, Jennifer Lapira, Ivan Wick, Laura Soverchia, Massimo Ubaldi, A.M. Polzonetti‐Magni, Doris E. Vidal‐Dorsch, Steven M. Bay, Joseph R. Gully, Jesus A. Reyes, Kevin M. Kelley, Daniel Schlenk, Ellen C. Breen, Roman Šášik, Gary Hardiman,
Endocrine disruptors include plasticizers, pesticides, detergents, and pharmaceuticals. Turbot and other flatfish are used to characterize the presence of chemicals in the marine environment. Unfortunately, there are relatively few genes of turbot and other flatfish in GenBank, which limits the use of molecular tools such as microarrays and quantitative reverse-transcriptase polymerase chain reaction (qRT-PCR) to study disruption of endocrine responses in sentinel fish captured by regulatory agencies. ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2008 - National Institute of Environmental Health Sciences | Environmental Health Perspectives
Tobias Weidner, Nicholas F. Breen, Kun Li, Gary P. Drobny, David G. Castner,
The power of combining sum frequency generation (SFG) vibrational spectroscopy and solid-state nuclear magnetic resonance (ssNMR) spectroscopy to quantify, with site specificity and atomic resolution, the orientation and dynamics of side chains in synthetic model peptides adsorbed onto polystyrene (PS) surfaces is demonstrated in this study. Although isotopic labeling has long been used in ssNMR studies to site-specifically probe the structure and dynamics of biomolecules, the potential of SFG to probe ...
Tópico(s): Solid-state spectroscopy and crystallography
2010 - National Academy of Sciences | Proceedings of the National Academy of Sciences
Rocco R. Addante, Gary H Breen,
Tópico(s): Medical Imaging and Pathology Studies
1996 - Elsevier BV | Journal of Oral and Maxillofacial Surgery
Phenyl allylcarbonates are useful acylating agents for the enzymatic resolution of 1-methyl tetrahydroisoquinoline.
Tópico(s): Pharmacogenetics and Drug Metabolism
2004 - Elsevier BV | Tetrahedron Asymmetry
Ian P. Andrews, Richard J. Atkins, Neil F. Badham, Richard K. Bellingham, Gary F. Breen, John Carey, Stephen K. Etridge, Jerome F. Hayes, Nigel Hussain, David O. Morgan, Andrew C. Share, Stephen A. Smith, Timothy C. Walsgrove, Andrew S. Wells,
A new synthesis of lotrafiban SB-214857-A is reported. The key steps are the preparation of racemic (4-methyl-3-oxo-2,3,4,5-tetrahydro-1H-benzo[e][1,4]diazepin-2-yl)-acetic acid methyl ester from 2-nitrobenzyl alcohol, a resolution using an immobilised lipase enzyme and a palladium-catalysed aminocarbonylation reaction.
Tópico(s): Multiple Myeloma Research and Treatments
2001 - Elsevier BV | Tetrahedron Letters
Anne‐Céline Martin, William Thomas, Zahra Mahir, Maeve P. Crowley, Terry Dowling, Karen Breen, V. Collings, Gary Moore, Stephen MacDonald, Beverley J. Hunt, Alexander T. Cohen,
Abstract Background Direct oral anticoagulants (DOACs) are prescribed for atrial fibrillation (AF) and venous thromboembolism (VTE) and both occur more frequently in obese patients. Outcomes from DOAC trials included few individuals ≥ 120 kg leading to uncertainty whether high body weight (BW) reduces DOAC concentrations. Objectives This article investigates the relationship between factor Xa (FXa) inhibitor concentrations, BW, and renal function, and compares them in high BW patients with unselected populations. ...
Tópico(s): Cardiac Arrhythmias and Treatments
2020 - Thieme Medical Publishers (Germany) | Thrombosis and Haemostasis