Waldemar Januszczak, John Dugdale, Michael Prescott, Richard Jeffrey, Mark Stretton, Barney Spender, Barbara Hall, Alec Stewart, San Francisco Symphony, Christopher Morgan Religious Affairs Correspondent, Jeff Dawson, N J, Jon Swain, James Clark, Nicholas Rufford, George Flyde, Rob Hughes, John Peter, John Mooney, Jonathan Miller, John Jay, J D, Adam Luck, Jon Pratty, Emine Saner, Cherie Blair, Frank Whitford, Anderson Investigates, Gordon Stewart, Paul Sanders, Keith Potts, Sam Gilpin, Sally Payne, Melanie Rickey, David Smith, Tim Richards, Melanie Phillips, Neil Wormald, E P, Clive Davis, Joe Lauria, Vincent Kearney, Mary Wilson, K R, Dr Roger Henderson, Tony Allen-Mills, Simon Wilde, Nixon Carter, Martin James, Tom Walker, David Greene Circulation Director, Malcolm Brook, Robert Winnett, Irwin Stelzer, Robert Hewison, Peter Wilson, John Dickinson, Adam Tanswell, Professor Nick Bosanquet, John Gribbin, John Evans, Philip Kingsley, Thrasy Petropoulos, Steve Curry, David Reekie, Sarah Toyne, David Hewson, Jo Glanville Blackburn, Tania Alexander, Margaret Coles, Hugh Canning, Margarette Driscoll, Alasdair Reid, Chris Dedicoat, John Sutherland, Jeremy Clarkson, Stewart Lee, Edward Porter, Peter Conradi, Louise Taylor, S L, Max Anderson, Felicity Wilcox, Eben Black, David Crane, Professor Tim Congdon, P Hancox, John Fawcett, Nick Caln, John Hart, Liz Jones, Kevin Rafter, Alex Kershaw, Andy Bannister, Nick Gardner, Timothy St Ather, B Porter, Michael Tilson Thomas, Phillip Oppenheim, Paul Ham, Rick Francis, Paul Donovan, Deborah Collcutt, Alastair Hendy, Digby Hildreth, Tim Salmon, Simon Mills, Hugh McIlvanney, Susan Clark Health Journalist, Andrew Barratt, Lucinda Kemeny, Jasper Gerard, Paul Driver, John Humphrys, Nick Newman, Peter Windsor, Sue Fox, Nigel Burnham, Ann McFerran, Ian Hawkey, Shelley Von Strunckel, Alex Clark, Madonna, Christopher Morgan, Harald Doornbos, Walter Grey, Mark Edwards, Susan Clark, Colin Angwin, David Lawrenson, Eben Black Chief Political Correspondent, Danny O'Brien, Phil Baker, Lois Rogers, Simon Veness, Raymond Keene, Peter Martin, Gerry Berger, Senay Boztas, Cosmo Landesman, Lisa Brinkworth, Marie Colvin, Diana Wright, Marion Phillips, William Peakin, Andy Knott, Los Angeles, Chris Partridge, Michael Prescott Political Editor, Stephen Jones, Stephen Bleach, Richard Evans, Uzi Mahnaimi, Natalie Graham, Lois Rogers Medical correspondent, Dominic Rushe, Professor Douglas McWilliams, Keith Wheatley, Pat Butcher, Claire Oldfield, David Walsh, Sir Howard Davies, Mark MacAskill, Wendy Bristow, Trevor Lewis, Jack Grimston, S P, Colin McDowell, Ben Pimlott, Stephen Armstrong, Nick MacKinnon, Professor David Gowland, Christopher Goodwin, Paul Kavanagh, Bethan Cole, Mark Prigg, Victoria O'brien, Clover Dahl, Maurice Chittenden, Alex Fortune, Kevin Pratt, Nick Hanna, Alasdair Reid golf correspondent, Dr Patrick Moore, Andrew Lorenz Business Editor, Richard Rae, Mark Franchetti, John Wilcockson, Ray Hutton, Jon Ungoed-Thomas, Arthur J Hayward-Costa, Gus MacDonald, D J Taylor, Anthony Johnson, Charles Pelkey, Christopher Tennant, Michael Brady, John Harlow, Godfrey Smith, John Urbanek, Dipesh Gadher, Richard George, Hunter Davies, Ann Natanson, A A Gill, Matthew Campbell, John Carey, Joel Lardner, Philip Webster, Nadine Meisner, David Sumner Smith, Dr Walter Eltis, Nick Fielding, Stephen Pettitt, Jonathan Leake Science Editor, David Clark, Rw Johnson, Geoffroy Tailleur, Andrew Lorenz, Sally Kinnes, Steven Weaver, Nicholas Hellen Media Editor, Tim Little-wood, Liam Clarke, Roger Dobson, Frank Prochaska, David Wickers, Sirl Dal, John Cornwell, Adam Manktelow, Mark Hodson, Andrew Frankel, Graham Norwood, Christine Lees, Rupert Steiner, Hugh Pearman, R Sylvester, Dan Cairns, Christopher Bray, David Parsley, Bill Cotton, David Smith Economics Editor, Arthur Welss, Tom Deveson, Simon Crerar, Peter Roebuck, Professor Anthony Clare, Walter Ellis, Joanna Simon, India Knight, Steve Grant, Simon Howard, Danny Danziger, Dan Pearson, A Fraser, Rosie Waterhouse, Kate Constable, Boris Schapiro,
... cond David Parry Chandos Opera in English Series Chan 3035, £13.99 Dufay O gemma lux-Isorhythmic motets Huelgas Ensemble, dir Paul Van ...
2000 - Gale Group | Sunday Times HA GDA
... Darling. Twenty-six minutes in, a host describes Gemma Chan, who has a supporting role in the film, ... up the culture that produced this conversation about Gemma Chan's beauty in the 2022 monograph Racist Love. ...
Tópico(s): Asian Culture and Media Studies
2024 - University of Illinois Press | Journal of American Ethnic History
John-Paul Flintoff, David Mills, Sally Brock, Dana Facaros, P K, Amanda Ursell, Dwayne Peel Wales scrum-half, Ben Smalley, Garry Kasparov, Jim Callaghan, Neil Wormald, Alison Hollins, Martin James, Anthony Sattin, Rosie Millard, David Hewson, Norman Harrison Director, Hugh Canning, John Sutherland, Dean Godson, Sarah Dempster, Rev Alan Hughes, Shelley Von Strunckel, Christopher Morgan, Sarah Gracie, Antony Edmonds, Edward Poerter, David Griffiths, Robbie Hudson, Niall Dickson, Emma Smith, Michael Wright, James Dyson, Nick Rennison, S A, Rowan Williams, Nargess Gharani, Bryan Appleyard, John Elliott, M L, Richard Brooks Arts Editor, Lillian McEvoy, Dan Box, Gareth Jenkins, David Winner, Alex Pell, Matthew Campbell, Mary Braid, Nick Fielding, Tim Steer, Peter Munro, Shane Williams Wales wing, J P, Graham Norwood, Andrew Male, David Budworth, William Lewis Business editor, Mike Hammond, Ben Rooney, Brian Schofield, Jason Dawe, Sian Griffiths, Elizabeth Johnstone, Peter Stanford, Jonathan Northcroft, Stephen Jones rugby correspondent, Matthew Wall, John Smith, Lucas Hollweg, Jim Munro, Jasper Rees, Lara Morgan, Andrew Longmore, Phil Tomaselli, Claire Pettingale, Richard Green, E P, Andrew Sullivan, Clive Davis, Diane Cambell, Paul Wolfowitz, John Bellchambers, Aidan O'Carroll, John Waples Deputy Business Editor, Stuart Barnes, Peter Jones, Cally Law, Sophie B Hawkins, Maria Misra, Victoria Segal, Edward Porter, Clare Gascoigne, Anthony Peregrine, Dave Pollard, John Hart, Jeff Potter, Andrew Porter Deputy Political Editor, Brendan Bourne, Mike Laws, Stuart Wavell, Paul Donovan, Nick Sullivan fashion director, Cliff McQueen, Peter Hounam, Sir Andrew Green Chairman, Hugh McIlvanney, Tim Moore, Richard Brooks, Stuart Andrews, David Leppard, Raj Kothari, Lois Rogers, Gareth Huw Davies, David Cracknell, Diana Wright, Barry Flatman, Natalie Graham, Mike Nicholls, David Walsh, Mr Cole, Paul Trowell, Zoë Ball, Stephen Armstrong, Wilfred Emmanuel-Jones, Michael Sheridan Far East Correspondent, N R, Richard Woods, Chris Carson, Ray Hutton, Joel Reindorp, M E, Fay Weldon, Dileep Premachandran, Rod Stewart, Russell Shorto, A A Gill, Brian Glanville, J Hammond, Jeremy Langmead, Colin McDOWELL'S, Daniel Emery, Nigel Powell, Keith Fisher, Sophie Harrison, John Aizlewood, Jeremy Lazell, Hugh Pearman, Rachel De Thame, Emma Burns, Jason Crump, Waldemar Januszcz, Normal Coxall, Helen Stewart, John Dugdale, Barbara Hall, Daniel Day-Lewis, Mike Ruddock Wales coach, Hari Kunzru, Rob Hughes, John Peter, Donna Leon, Jane Mulkerrins, Susan d'Arcy, Che Tsang, Jerry Partrick, David Smith, David Cracknell Political Editor, Nicola Gordon, Tom Walker, Dipesh Gadher Transport Correspondent, Adrian Furnham, Nicholas Hellen Social Affairs Editor, John Arlidge, Rhianna Pratchett, Warren Shore, H C, Sharon Ridoyna, Stewart Lee, Deirdre Le Faye, Peter Conradi, Michael Portillo, Patricia Nicol, Lindsay Baker, Eleanora Cunietti, Richard Fletcher, Jeremy Guscott, David Walsh Chief Sports Writer, Sarah-Kate Templeton, Betsy Blair Reisz, Debbie Cowan, Michael Rosen, Paul Kimmage, Chris Woodhead, Jocelyn Charles, Audrey Carden, Mark Edwards, Rachel Bridge, Susan Clark, Glenda Cooper, Boris Becker, Raymond Keene, Hywel Thomas, Hala Jaber Foreign Reporter of the Year, Stanley Stewart, Zoe Brennan, Kipper Williams, Stephen Jones, Stephen Bleach, Louise Armitstead, Nick Cain, Frankel, Angela Laing, Trevor Lewis, Roland White, Richard Rae, David Carnings, Jon Ungoed-Thomas, Dipesh Gadher, John Waples, Kevin Morgan Wales try-scorer, Jessica Brown, Stephen Pettitt, Maria McErlane, Justin Sparks, Peter Done managing director, Dan Cairns, David Smith Economics Editor, James Luckhurst, Simon Howard, Dominic Rushe, Karen Robinson, Hilary Spurling (Author of The Unknown Matisse and Matisse the Master), Christine Lennon, Scott Athorne, Helena Frith Powell, Helen Davies, Gideon Garter, Robin Eggar, Brent Cockbain Wales lock, Frank Whitford, Kathryn Cooper, P D, Martin Brundle, C Stobbart, Geoff Lloyd, Andy Brough, Andrew Porter, Tony Allen-Mills, Simon Wilde, Robert Winnett, Peter Wilson, James Martin, David Dougill, Jonathon Carr-Brown, Paul Forsyth, Geraldine Hackett Education Correspondent, Mark Edmonds, Jeremy Clarkson, David Cairns, Greg Struthers, Lydia Slater, Demetrios Matheou, Irwin Steltzer, Richard Johnson, Richard Gosling, Roger Eglin, David Jones, Ivo Fennant, Simon Mills, Michael Owen Wales captain, Jasper Gerard, Derek Clements, Paul Driver, Ian Hawkey, Paul Durman, Lisa Grainger, Jonathon Carr-Brown Health Correspondent, Phil Baker, Victoria O'Brien, C L, Rod Liddle, Cosmo Landesman, Stephen Pettitt Pettitt, Helen Hawkins, Blower Spindle, Richard Fortey, Caroline Donald, David Carins, Brian O'Driscoll Ireland captain, Shane Watson, Ian Smith, Roger Lewis, Brian Graham, Clare Francis, Anne Wayne, John Harlow, Mark Kleinman, Gareth Thomas injured Wales Captain, Miranda Seymour's, Jessica Bown, Sally Kinnes, Naomi Caine, Peter Almond, Sam Nunn, Minette Marrin, Louise King, Andrew Davidson, Pete Oliver, Eddie O'Sullivan Ireland coach, Matthew Goodman, India Knight, Adrian Somerfield, Penelope Lively,
... Magic Flute Cast, LPO, cond Charles Mackerras Chandos CHAN 3121(2) (2 CDs) Pascal Dusapin Perela, uomo ...
2005 - Gale Group | Sunday Times HA GDA
Judy Truong, Andrew T. Yan, Gemma Cramarossa, Kelvin Chan,
Chemotherapy-induced cardiotoxicity is a major cause of morbidity and mortality in cancer survivors. It might manifest as arrhythmia, hypertension, myocardial ischemia, thromboembolism, heart failure, systolic dysfunction, or other adverse events. Anthracyclines and trastuzumab are the chemotherapeutic agents with the most documented cardiac side effects; however, the array of novel molecular targeting therapies available is concerning because their side effects are not yet well understood. Nevertheless, ...
Tópico(s): Cancer Treatment and Pharmacology
2014 - Elsevier BV | Canadian Journal of Cardiology
Richard Mabey, Maggie Rosen, Jonathan Northcroft, Toby Elliott Commanding Officer, Waldemar Januszczak, William Leith, Hala Jaber, John Dugdale, Malcolm Brown, William Kay, Chris Whyham, Barbara Hall, Helena Frith Powell, Maya Jasanoff, Jeff Dawson, Sally Brock, Helen Davies, Peter Whittle, Michael Burleigh, Rob Hughes, John Peter, Maggie Alderson, Uzi Mahanaimi, Samuel Palmer, Jasper Rees, Terry Coleman, Julie Earle, John Waples Business Editor, Spencer May, Jack Humphrey, Ruth Rogers, Peter Day, Shaun Bailey, Norma Barzman, Frank Whitford, David Gower, Christy Campbel, Kathryn Cooper, Peter Feltham, D Marchessini, P D, David Smith, Olwyn Ni Chroinin, Neil Wormald, A A Gills, E P, Clive Davis, Mark Kieinman, Michael Munn, Andrew Porter, Anthony G Philips, Irwine Stelzer, Tony Allen-Mills, Simon Wilde, Martin James, Gemma Scott-Martin, Tom Walker, Anthony Sattin, Robert Winnett, Rob Long, Dipesh Gadher Transport Correspondent, Clive Coates, Matt Rudd, Sean Fitzpatrick, Peter Wilson, Tim Richard, Rosie Millard, David Dougill, Julia Bailey, Joan Didion, Matthew Sweet, Christopher Hart, Robert Winnett Whitehall Correspondent, H Bradley, Stuart Barnes, Stewart Lee, T J R, Matt Skinner, David Vise's, Cally Law, Hugh Canning, Vincent Gasnier, Stphen Jones, Jeremy Clarkson, Andrew Stone, Edward Porter, Peter Conradi, Victoria Segal, Nicola Smith, Dean Nelson, Michael Portillo, Clare Gascoigne, Michael Talbot, Tommy Gemmell, Anthony Peregrine, Patricia Nicol, Greg Gordon, Sarah Dempster, James Sharpe, M P, Paddy Crerand, Nigel Perry, Nick Caln, Richard Fletcher, Lydia Slater, Jeff Potter, Niki Lauda, Andrew Porter Deputy Political Editor, Dan Drillsma-Milgrom, Christopher Frayling, John Blundell, David Walsh Chief Sports Writer, Dr Joseph Watson, Robin Scott-Elliot, Christopher Silvester, Roger Eglin, Guillermo Gabriel Zotta, Kathrina Burroughs, Paul Donovan, Julian Fellowes, Tom Stubbs, Giles Hattersley, Phyllis Maxwell, Chris Woodhead, C Higgins, Roja Dove, David Furnish, Jasper Gerard, Clare Frencis, Michael Woodhead, Paul Driver, John Humphrys, Jared Diamond, Pat Brennan, Sarah-Kate Temoleton, Ian Hawkey, Stuart Andrews, Liz Loxton, Elton John, David Leppard, David Pollard, Paul Durman, Phil McGuiness, Peter Kemp, Suzanne Finstad, Kirsty Lane, Mark Edwards, Bernica Rubens, Janet Daley, Rachel Bridge, Rachel North, Richard Doherty, Duncan Atherton, Emily Laurence Baker, Laura Shine Cunningham, Caroline Waldegrave, Lucien Musset, Richard Benson, Fiona Jerome, James Fox, Patrick Cockburn, Lois Rogers, Rose Prince, Patricis Nigel, Raymond Keene, Derek Dougan, Darwin Porter, Rod Liddle, Ian Bradwell, David Cracknell, Dominic O'Connell Deputy Business Editor, Zoe Brennan, Lauren Booth, Kipper Williams, Diana Wright, Robbyn Swan, Emma Smith, Helen Hawkins, Dr Margaret Gullan-Wh, Stephen Jones, Stephen Bleach, Andrew Holgate, Nick Cain, Ian Gray, Thomas Jarrett, Anna Gavela, Natalie Graham, Chris Roberts, Caroline Donald, Tom Stevenson, Colin McDOWELL, Jessica Brinton, David Walsh, Caroline Gascoigne, Helen Stewart, Bryan Appleyard, Stephen Armstrong, John Elliott, Mark Stucklin, Zoe Brennam, Janine Shaw, Geoffrey Palmer, Richard Woods, Roland White, Shane Watson, P J Harris, Abul Taher, High Mcllvanney, Dr John Pitts, Richard Rae, Mark Franchetti, Roberta Taylor, Jon Ungoed-Thomas, Fizz Carr, Jonathan Leake, Clive Davies, M E, Michael Sheridan, Clare Francis, Damian Spellman, Anthony Summers, Tony Judt, Tilda Swinton, Thomas Lynch, Chris Haslam, Tom Baird, Edward Scissorthands, Hugh Fearnley-Whittingstall, E p, Diana Melly, Lynn Whittlesea, Nigel Slater, Alex Pell, David Diprose, Alistair Sampson, Philip Kerr author, Tom Hennigan, David Sanderson, Stephen Jones Rugby Correspondent, Jamie Goode, Simon Jenkins, Stephen Pettitt, Claudia Croft, Will Iredale, Jonathan Leake Science Editor, Peter Heather, Claudia Roden, Sally Kinnes, Naomi Caine, Stanley Brahams, Nigel Powell, Baroness Young, David Wickers, Roger Dobson, Rose Gray, Brian Doogan, Helena Christensen, Ben Dowell, Michael Underwood, Clifford Bishop, Neil White, Nicholas Faith, Andrew Frankel, Graham Norwood, Seb Morton-Clark, Joe Lovejoy, John Hays, Jonathan Futrell, Shelley Von Strunckel, Hugh Pearman, Sarath Dempster, Andrew Davidson, Dan Cairns, Jamie Oliver, E A M, M Mistry, Gereth Huw Davies, David Smith Economics Editor, Frank Whifford, Stefan Gates, Sarah Baxter, Cosmo Landerman, James Luckhurst, Brian Schofield, Joanna Simon, Matthew Goodman, C J Jackson, Fleur Britten, Sara Hassan, India Knight, Simon Howard, Tom Holland, Jason Dawe, Dominic Rushe, David Thomson, Paul, Sian Griffiths, Stephen Pollard,
... to Be People of the Week Blair Thinks Chan's the Man Bouncing pet of the week ...
2005 - Gale Group | Sunday Times HA GDA
Victoria M. McLeod, Linda J. Chan, Gemma M. Ryan, Christopher J. H. Porter, Lisa M. Kaminskas,
ABSTRACT The utility of inhaled protein therapeutics to treat lung-resident diseases is limited by protein degradation in the lungs and rapid clearance. This study therefore aimed to evaluate the impact of PEGylation on the lung and systemic exposure of interferon (IFN) α2 after intratracheal administration to rats. An inverse correlation was observed between PEG chain length and systemic exposure, where bioavailability was 5.5% for the 31kDa PEGylated construct and <0.4% for the 60kDa PEGylated construct ...
Tópico(s): Neonatal Respiratory Health Research
2015 - Elsevier BV | Journal of Pharmaceutical Sciences
N. Gaikwad, Thomas Butler, Ryan Maxwell, Elizabeth Shaw, W. Strugnell, Jonathan Chan, Gemma A. Figtree, R. Slaughter, Christian Hamilton‐Craig,
Late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (CMR) has been recommended to distinguish Tako-tsubo cardiomyopathy (TTC) from either acute myocardial infarction or myocarditis. 44 consecutive patients with confirmed Mayo Clinic criteria for TTC underwent CMR imaging at 1.5 Tesla during the acute phase. 10 patients who had CMRI to exclude scar related ventricular tachycardia, and had negative studies, were used as negative controls. LGE was quantitated at two signal intensity ...
Tópico(s): Cardiac Structural Anomalies and Repair
2016 - Elsevier BV | IJC Heart & Vasculature
Yip Han Chin, Cheng Han Ng, Nicholas Chew, Gwyneth Kong, Wen Hui Lim, Darren Jun Hao Tan, Kai En Chan, Ansel Shao Pin Tang, Daniel Q. Huang, Mark Y. Chan, Gemma A. Figtree, Jiong‐Wei Wang, Asim Shabbir, Chin Meng Khoo, Vincent Wai‐Sun Wong, Dan Yock Young, Mohammad Shadab Siddiqui, Mazen Noureddin, Arun J. Sanyal, David E. Cummings, Nicholas Syn, Mark Muthiah,
There is a growing number of trials examining the effectiveness of pharmacotherapies for obesity, however, little is known about placebo and nocebo effect in these trials. Hence, we sought to examine the effect of placebo in obesity trials, to better understand the potential factors affecting clinical endpoints in them.Medline, Embase, and Cochrane CENTRAL were searched for articles examining weight-loss RCTs examining patients with overweight or obesity in placebo-controlled arms from inception ...
Tópico(s): Pharmacology and Obesity Treatment
2022 - Elsevier BV | EClinicalMedicine
Yip Han Chin, Oliver Lim, Chaoxing Lin, Y.‐Y. CHAN, Gwyneth Kong, Cheng H. Ng, Bryan Chong, Nicholas Syn, Kai En Chan, Mark Muthiah, Mohammad Shadab Siddiqui, Jiong‐Wei Wang, Gemma A. Figtree, Mark Y. Chan, Nicholas Chew,
Abstract Background Randomized controlled trials (RCTs) of lipid-lowering therapy (LLT) in which the control groups received placebo without background LLT offer unique insights into the placebo and nocebo effects of lipid-lowering RCTs. Methods and results Embase and Medline were searched for hyperlipidaemia RCTs with placebo-controlled arms. Placebo arms with background LLT were excluded. A single arm meta-analysis of proportions was used to estimate major adverse cardiovascular events (MACE) and ...
Tópico(s): Meta-analysis and systematic reviews
2022 - Oxford University Press | European Heart Journal - Quality of Care and Clinical Outcomes
Nicholas Chew, Cheng Han Ng, Darren Jun Hao Tan, Gwyneth Kong, Chaoxing Lin, Yip Han Chin, Wen Hui Lim, Daniel Q. Huang, Jingxuan Quek, Clarissa Elysia Fu, Jieling Xiao, Nicholas Syn, Roger Foo, Chin Meng Khoo, Jiong‐Wei Wang, Georgios K. Dimitriadis, Dan Yock Young, Mohammad Shadab Siddiqui, Carolyn S.P. Lam, Yibin Wang, Gemma A. Figtree, Mark Y. Chan, David E. Cummings, Mazen Noureddin, Vincent Wai‐Sun Wong, Ronald C.W., Christos S. Mantzoros, Arun J. Sanyal, Mark Muthiah,
Summary Global estimates of prevalence, deaths, and disability-adjusted life years (DALYs) from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019 were examined for metabolic diseases (type 2 diabetes mellitus [T2DM], hypertension, and non-alcoholic fatty liver disease [NAFLD]). For metabolic risk factors (hyperlipidemia and obesity), estimates were limited to mortality and DALYs. From 2000 to 2019, prevalence rates increased for all metabolic diseases, with the greatest increase in high socio- ...
Tópico(s): Diet, Metabolism, and Disease
2023 - Cell Press | Cell Metabolism
Janet Barnsley, Gemma L. Buckland, P. E. Chan, Angel M. Ong, Ana Rita Saldanha Ramos, Mark Baxter, Faidra Laskou, Elaine Dennison, Cyrus Cooper, Harnish P. Patel,
Osteoporosis, a common chronic metabolic bone disease is associated with considerable morbidity and mortality. As the prevalence of osteoporosis increases with age, a paralleled elevation in the rate of incident fragility fractures will be observed. This narrative review explores the origins of bone and considers physiological mechanisms involved in bone homeostasis relevant to management and treatment. Secondary causes of osteoporosis, as well as osteosarcopenia are discussed followed by an overview ...
Tópico(s): Bone health and treatments
2021 - Springer Science+Business Media | Aging Clinical and Experimental Research
Suk Chon, Yun Jung Lee, Gemma Fraterrigo, Paolo Pozzilli, Moon Chan Choi, Mikwang Kwon, Sang Ouk Chin, Sang Youl Rhee, Seungjoon Oh, Young-Seol Kim, Jeong‐Taek Woo,
Aims: It is necessary to evaluate glucose variability and postprandial hyperglycemia in patients with well-controlled type 2 diabetes mellitus because of the limitations associated with hemoglobin A1c (HbA1c) measurements. We evaluated parameters reflecting postprandial hyperglycemia and glycemic variability in patients with optimal HbA1c. Patients and Methods: Thirty-nine patients with HbA1c levels below 7% were recruited to the study. A continuous glucose monitoring system (CGMS) was applied for ...
Tópico(s): Pancreatic function and diabetes
2013 - Mary Ann Liebert, Inc. | Diabetes Technology & Therapeutics
Lance Turtle, Tanushka Bali, Gemma Buxton, Savita Chib, Sajesh Chan, Mohammed Soni, Mohammed Hussain, Heather Isenman, Prachi Fadnis, Manjunatha M. Venkataswamy, Vishali Satishkumar, Penny Lewthwaite, Ayako Kurioka, Srinivasa Krishna, M. Veera Shankar, Riyaz Ahmed, Ashia Begum, Vasanthapuram Ravi, Anita Desai, Sutee Yoksan, Stefan Fernandez, Christian B. Willberg, Henrik N. Kløverpris, Christopher P. Conlon, Paul Klenerman, Vijaya Satchidanandam, Tom Solomon,
Japanese encephalitis (JE) virus (JEV) is an important cause of encephalitis in children of South and Southeast Asia. However, the majority of individuals exposed to JEV only develop mild symptoms associated with long-lasting adaptive immunity. The related flavivirus dengue virus (DENV) cocirculates in many JEV-endemic areas, and clinical data suggest cross-protection between DENV and JEV. To address the role of T cell responses in protection against JEV, we conducted the first full-breadth analysis ...
Tópico(s): Viral Infections and Vectors
2016 - Rockefeller University Press | The Journal of Experimental Medicine
Mohammed Nabil Quraishi, Martin J. Sergeant, Gemma L. Kay, Tariq Iqbal, Jacqueline Chan, Chrystala Constantinidou, Palak Trivedi, James Ferguson, David H. Adams, Mark J. Pallen, Gideon M. Hirschfield,
Primary sclerosing cholangitis–IBD (PSC–IBD) is an inflammatory autoimmune hepato–biliary–enteric disease in which it is predicted that gut microbiota have potential pathophysiological effects, relevant to disease initiation and outcome. The recent article by Kummen et al 1 who reported that the gut microbiota in PSC is distinct compared with those from healthy controls and patients with UC without liver disease, is therefore of interest. However, it remains unclear if these alterations in the gut ...
Tópico(s): Microscopic Colitis
2016 - BMJ | Gut
Ina Laura Pieper, Gemma Radley, Chris H. H. Chan, Yasmin Friedmann, Graham R. Foster, Catherine A. Thornton,
Abstract Ovine and bovine blood is used heavily within the development of blood‐handling medical devices, such as heart pumps (left ventricular assist devices, LVADs), for which blood cell damage needs to be monitored during in vitro testing. Hematology analyzers provide cell counts but no information about cell viability. The anthraquinone DNA dyes CyTRAK Orange™ and DRAQ7™ have practical and spectral properties rendering them suitable for multicolor assays. Compared to other DNA dyes such as Vybrant ...
Tópico(s): CRISPR and Genetic Engineering
2016 - Wiley | Cytometry Part A
Gwyneth Kong, Yip Han Chin, Jieyu Lim, Cheng H. Ng, Kannan Shankar, Bryan Chong, Chaoxing Lin, Kai En Chan, Vickram Vijay Anand, Ethan C. Z. Lee, Shaun Seh Ern Loong, Zhen Yu Wong, Chin Meng Khoo, Mark Muthiah, Roger Foo, Georgios K. Dimitriadis, Gemma A. Figtree, Yibin Wang, Mark Y. Chan, Nicholas Chew,
Abstract Objective With rising prevalence of hypertension and obesity, the effect of hypertension in obesity remains an important global issue. The prognosis of the US general population with obesity based on hypertension control was examined. Methods This study examined participants from the National Health and Nutrition Examination Survey between 1999 and 2018. Individuals with obesity were stratified into no hypertension, controlled hypertension, and uncontrolled hypertension. The study outcome ...
Tópico(s): Nutritional Studies and Diet
2023 - Wiley | Obesity
Gemma Slater, Peter Levy, K. L. Andrew Chan, Camilla Larsen,
Chemotaxis is important for the survival of most animals. How the brain translates sensory input into motor output beyond higher olfactory processing centers is largely unknown. We describe a group of excitatory neurons, termed Odd neurons, which are important for Drosophila larval chemotaxis. Odd neurons receive synaptic input from projection neurons in the calyx of the mushroom body and project axons to the central brain. Functional imaging shows that some of the Odd neurons respond to odor. Larvae ...
Tópico(s): Plant and animal studies
2015 - Society for Neuroscience | Journal of Neuroscience
Tara Behroozian, Pierluigi Bonomo, Partha Patel, Lauren Kanee, Samuel Finkelstein, Corina van den Hurk, Edward Chow, Julie Ryan Wolf, Tara Behroozian, Pierluigi Bonomo, Partha Patel, Lauren Kanee, Samuel Finkelstein, Corina van den Hurk, Edward Chow, Julie Ryan Wolf, Suvam Banerjee, Carlotta Becherini, Christine B. Boers‐Doets, Marta Carlesimo, Gemma Caro, Maria Caterina Fortuna, Adrian Wai Chan, Lorraine C. Drapek, Azael Freites‐Martínez, Satoshi Hirakawa, Emily H. Smith, Nicola Alessandro Iacovelli, Bernice Y. Kwong, Shing Fung Lee, Alina Markova, Robert F. Miller, Gustavo Nader Marta, Silvina Pugliese, Claire Marie Reyes Habito, Jolien Robijns, Viola Salvestrini, Leonard Christopher Schmeel, Mateusz Spałek, Mark Trombetta, Henry C. Y. Wong,
Summary Acute radiation dermatitis is a frequent adverse effect of radiotherapy, but standardisation of care for acute radiation dermatitis is lacking. Due to the conflicting evidence and variability in current guidelines, a four-round Delphi consensus process was used to compile opinions of 42 international experts on care for people with acute radiation dermatitis on the basis of the evidence in existing medical literature. Interventions for acute radiation dermatitis prevention or management that reached ...
Tópico(s): Cancer survivorship and care
2023 - Elsevier BV | The Lancet Oncology
Bryan Chong, Gwyneth Kong, Kannan Shankar, H.S. Jocelyn Chew, Chaoxing Lin, Rachel Goh, Yip Han Chin, Darren Jun Hao Tan, Kai En Chan, Wen Hui Lim, Nicholas Syn, Siew Pang Chan, Jiong‐Wei Wang, Chin Meng Khoo, Georgios K. Dimitriadis, Karn Wijarnpreecha, Arun J. Sanyal, Mazen Noureddin, Mohammad Shadab Siddiqui, Roger Foo, Anurag Mehta, Gemma A. Figtree, Derek J. Hausenloy, Mark Y. Chan, Cheng Han Ng, Mark Muthiah, Mamas A. Mamas, Nicholas Chew,
A significant proportion of premature deaths globally are related to metabolic diseases in young adults. We examined the global trends and mortality of metabolic diseases in individuals aged below 40 years using data from the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019.From 2000 to 2019, global estimates of deaths and disability-adjusted life years (DALYs) were described for metabolic diseases (type 2 diabetes mellitus [T2DM], hyperlipidemia, hypertension, obesity, non-alcoholic ...
Tópico(s): Global Public Health Policies and Epidemiology
2023 - Elsevier BV | Metabolism
Gemma L.M. Hinchliff, Adrian B. Kelly, Gary Chan, George Patton, Joanne Williams,
This study examined the association of risky dieting amongst adolescent girls with depressed mood, family conflict, and parent-child emotional closeness.Grade 6 and 8 females (aged 11-14years, N=4031) were recruited from 231 schools in 30 communities, across three Australian States (Queensland, Victoria, and Western Australia). Key measures were based on the Adolescent Dieting Scale, Short Mood and Feelings Questionnaire, and widely used short measures of family relationship quality. Controls included ...
Tópico(s): Child and Adolescent Psychosocial and Emotional Development
2016 - Elsevier BV | Eating Behaviors
M. Thomson, Eng‐Cheng Chan, John Falconer, Gemma Madsen, Simon Geraghty, Neil Curryert, John Boulton, Roger Smith,
Abstract We have employed an in vitro system to study the time‐course of β ‐endorphin ( β ‐EP) immunoreactivity release from anterior pituitary cells stimulated with corticotropin‐releasing factor (CRF) and whether exposure to CRF desensitizes the cells to subsequent stimulation. Ovine anterior pituitaries were enzymatically disrupted into single cells, mixed with Siegel P2 and superfused in mini‐columns with carbogen‐gassed medium at 37 °C. Superfusate fractions were collected at 5‐min intervals and ...
Tópico(s): Neuropeptides and Animal Physiology
1990 - Wiley | Journal of Neuroendocrinology
E.-C. Chan, John Falconer, Gemma Madsen, Kenner C. Rice, Elizabeth L. Webster, George P. Chrousos, Roger Smith,
In sheep, corticotropin-releasing hormone (CRH) can stimulate the fetal release of ACTH to produce a cortisol surge which leads to the onset of parturition. We tested the hypothesis that fetal CRH is a primary factor in the onset of parturition in sheep by using a Type I CRH receptor antagonist, antalarmin, to block the endogenous action of CRH. Pregnant ewes were cannulated at 130-135 days of gestation. Five catheters were placed into the amniotic sac, fetal femoral artery, fetal tarsal vein, maternal ...
Tópico(s): Stress Responses and Cortisol
1998 - Oxford University Press | Endocrinology
Louise Emmett, James Buteau, Nathan Papa, Daniel Moon, James Thompson, Matthew J. Roberts, Kris Rasiah, David A. Pattison, John Yaxley, Paul Thomas, Anthony Hutton, Shikha Agrawal, Amer Amin, Alexandar Blazevski, Venu Chalasani, Bao Ho, Andrew Nguyen, Victor Liu, Jonathan Lee, Gemma Sheehan‐Dare, Raji Kooner, Geoff Coughlin, Lyn Chan, Thomas W. Cusick, Benjamin Namdarian, Jada Kapoor, Omar Alghazo, Henry H. Woo, Nathan Lawrentschuk, Declan G. Murphy, Michael S. Hofman, Phillip D. Stricker,
Multiparametric magnetic resonance imaging (MRI) is validated for the detection of clinically significant prostate cancer (csPCa), although patients with negative/equivocal MRI undergo biopsy for false negative concerns. In addition, 68Ga-PSMA-11 positron emission tomography/computed tomography (prostate-specific membrane antigen [PSMA]) may also identify csPCa accurately.This trial aimed to determine whether the combination of PSMA + MRI was superior to MRI in diagnostic performance for detecting csPCa. ...
Tópico(s): Urologic and reproductive health conditions
2021 - Elsevier BV | European Urology
Gwyneth Kong, Yip Han Chin, Bryan Chong, Rachel Sze Jen Goh, Oliver Zi Hern Lim, Cheng Han Ng, Mark Muthiah, Roger Foo, Stephen T. Vernon, Poay Huan Loh, Mark Y. Chan, Nicholas Chew, Gemma A. Figtree,
Background Standard modifiable cardiovascular risk factors (SMuRF), comprising diabetes, hyperlipidemia, hypertension, and smoking, are used for risk stratification in acute coronary syndrome (ACS). Recent studies showed an increasing proportion of SMuRF-less ACS patients. Methods Embase, Medline and Pubmed were searched for studies comparing SMuRF-less and SMuRF patients with first presentation of ACS. We conducted single-arm analyses to determine the proportion of SMuRF-less patients in the ACS ...
Tópico(s): Antiplatelet Therapy and Cardiovascular Diseases
2022 - Elsevier BV | International Journal of Cardiology
Jonathan C. M. Wan, Katrin Heider, Davina Gale, Suzanne Murphy, Eyal Fisher, Florent Moulière, Andrea Ruiz-Valdepeñas, Ángela Santonja, James Morris, Dineika Chandrananda, Andrea Marshall, Andrew B. Gill, Pui Ying Chan, Emily Barker, Gemma Young, Wendy N. Cooper, Irena Hudecova, Francesco Marass, Richard Mair, Kevin M. Brindle, Grant D. Stewart, Jean Abraham, Carlos Caldas, Doris M. Rassl, Robert C. Rintoul, Constantine Alifrangis, Mark R. Middleton, Ferdia A. Gallagher, Christine Parkinson, Amer Durrani, Ultan McDermott, Christopher G. Smith, Charles Massie, Pippa Corrie, Nitzan Rosenfeld,
Integration of variant reads across patient-specific mutation loci enables sensitive ctDNA quantification in plasma cell-free DNA sequencing data.
Tópico(s): Genomics and Phylogenetic Studies
2020 - American Association for the Advancement of Science | Science Translational Medicine
Gemma L. Kay, Martin J. Sergeant, Zhemin Zhou, Jacqueline Chan, Andrew Millard, Joshua Quick, Ildikó Szikossy, Ildikó Pap, Mark Spigelman, Nicholas J. Loman, Mark Achtman, Helen D. Donoghue, Mark J. Pallen,
Abstract Tuberculosis (TB) was once a major killer in Europe, but it is unclear how the strains and patterns of infection at ‘peak TB’ relate to what we see today. Here we describe 14 genome sequences of M. tuberculosis , representing 12 distinct genotypes, obtained from human remains from eighteenth-century Hungary using metagenomics. All our historic genotypes belong to M. tuberculosis Lineage 4. Bayesian phylogenetic dating, based on samples with well-documented dates, places the most recent common ...
Tópico(s): Genomics and Phylogenetic Studies
2015 - Nature Portfolio | Nature Communications
Yu‐Tzu Wu, Gemma‐Claire Ali, Maëlenn Guerchet, Matthew Prina, Kit Yee Chan, Martin Prince, Carol Brayne,
There are several existing systematic reviews of prevalence of dementia for mainland China, Hong Kong and Taiwan, but several studies have been newly reported. The aim of this study is to update prevalence data in this region and test for variation across geographical areas and time periods using the new dataset.
Tópico(s): Alzheimer's disease research and treatments
2018 - Oxford University Press | International Journal of Epidemiology
Vickram Vijay Anand, Ethan Lee Cheng Zhe, Yip Han Chin, Rachel Sze Jen Goh, Chaoxing Lin, Martin Tze Wah Kueh, Bryan Chong, Gwyneth Kong, Phoebe Wen Lin Tay, Mayank Dalakoti, Mark Muthiah, Georgios K. Dimitriadis, Jiong‐Wei Wang, Anurag Mehta, Roger Foo, Gary Tse, Gemma A. Figtree, Poay Huan Loh, Mark Y. Chan, Mamas A. Mamas, Nicholas Chew,
Abstract Background Low socioeconomic status (SES) is an important prognosticator amongst patients with acute coronary syndrome (ACS). This paper analysed the effects of SES on ACS outcomes. Methods Medline and Embase were searched for articles reporting outcomes of ACS patients stratified by SES using a multidimensional index, comprising at least 2 of the following components: Income, Education and Employment. A comparative meta-analysis was conducted using random-effects models to estimate the risk ratio ...
Tópico(s): Cardiac Health and Mental Health
2023 - Elsevier BV | International Journal of Cardiology
Gemma Bale, Subhabrata Mitra, Isabel de Roever, Marcus Chan, Alexander Caicedo-Dorado, Judith Meek, Nicola J. Robertson, Ilias Tachtsidis,
Perinatal hypoxic ischaemic encephalopathy (HIE) is associated with severe neurodevelopmental problems and mortality. There is a clinical need for techniques to provide cotside assessment of the injury extent. This study aims to use non-invasive cerebral broadband near-infrared spectroscopy (NIRS) in combination with systemic physiology to assess the severity of HIE injury. Broadband NIRS is used to measure the changes in haemodynamics, oxygenation and the oxidation state of cytochrome c oxidase (oxCCO). ...
Tópico(s): Neonatal and fetal brain pathology
2016 - Springer Nature | Advances in experimental medicine and biology
Rebecca White, Robindra Basu Roy,
... from peers, from families, and from society. As Gemma Chan's character in Dominic Savage's Channel 4 ...
Tópico(s): Grief, Bereavement, and Mental Health
2020 - Elsevier BV | The Lancet Child & Adolescent Health