Anna S. Berghoff, Thomas Hielscher, Gerda Ricken, Julia Furtner, Daniel Schrimpf, Georg Widhalm, Ursula Rajky, Christine Marosi, Johannes A. Hainfellner, Andreas von Deimling, Felix Sahm, Matthias Preusser,
Abstract Meningiomas are classified based on histological features, but genetic and epigenetic features are emerging as relevant biomarkers for outcome prediction and may supplement histomorphological evaluation. We investigated meningioma‐relevant mutations and their correlation with DNA methylation clusters and patient survival times. Formalin‐fixed and paraffin‐embedded samples of 126 meningioma patients (WHO grade I 52/126; 41.3%; WHO grade II: 48/126; 38.1%; WHO grade III: 26/126; 20.6%) were ...
Tópico(s): Pituitary Gland Disorders and Treatments
2022 - Wiley | Brain Pathology
Stephanie Barron, Sabine Eckmann, Museo Correr,
... alongside figures such as Christian Schad, Alexander Kanoldt, Georg Schrimpf, August Sander, Lotte Jacobi and Aenne Biermann. Also ...
Tópico(s): Italian Fascism and Post-war Society
2015 - Association of College and Research Libraries | Choice Reviews Online
... Edited by Jan. P. Beckmann, Ludger Honnefelder, Gangolf Schrimpf and Georg Wieland. Pp. xi+476. Hamburg: Felix Meiner, 1996. ...
Tópico(s): Medieval and Classical Philosophy
1998 - Cambridge University Press | The Journal of Ecclesiastical History
Tópico(s): Medieval Philosophy and Theology
1989 - Peeters | Revue Philosophique de Louvain
A profile of the German painter Georg Schrimpf. Schrimpf was an anarchist and member of the German Communist Party who later became a professor in Berlin and sold works to ...
Tópico(s): German Literature and Culture Studies
2000 - Deutscher Kunstverlag | Zeitschrift für Kunstgeschichte
Jelle Hendrix, Viola Baumgärtel, Waldemar Schrimpf, Sergey Ivanchenko, Michelle A. Digman, Enrico Gratton, Hans‐Georg Kräusslich, Bárbara Müller, Don C. Lamb,
Assembly of the Gag polyprotein into new viral particles in infected cells is a crucial step in the retroviral replication cycle. Currently, little is known about the onset of assembly in the cytosol. In this paper, we analyzed the cytosolic HIV-1 Gag fraction in real time in live cells using advanced fluctuation imaging methods and thereby provide detailed insights into the complex relationship between cytosolic Gag mobility, stoichiometry, and interactions. We show that Gag diffuses as a monomer ...
Tópico(s): Lipid Membrane Structure and Behavior
2015 - Rockefeller University Press | The Journal of Cell Biology
Philipp Sievers, Thomas Hielscher, Daniel Schrimpf, Damian Stichel, David Reuß, Anna S. Berghoff, Marian C. Neidert, Hans‐Georg Wirsching, Christian Mawrin, Ralf Ketter, Werner Paulus, Guido Reifenberger, Katrin Lamszus, Manfred Westphal, Nima Etminan, Miriam Ratliff, Christel Herold‐Mende, Stefan M. Pfister, David Jones, Michael Weller, Patrick N. Harter, Wolfgang Wick, Matthias Preusser, Andreas von Deimling, Felix Sahm,
Tópico(s): Head and Neck Surgical Oncology
2020 - Springer Science+Business Media | Acta Neuropathologica
Felix Sahm, Daniel Schrimpf, Damian Stichel, David Jones, Thomas Hielscher, Sebastian Schefzyk, Konstantin Okonechnikov, Christian Koelsche, David Reuß, David Capper, Dominik Sturm, Hans‐Georg Wirsching, Anna S. Berghoff, Peter Baumgarten, Annekathrin Kratz, Kristin Huang, Annika K. Wefers, Volker Hovestadt, Martin Sill, Hayley Ellis, Kathreena M. Kurian, Ali Fuat Okuducu, Ho‐Keung Ng, Katharina Drueschler, Matthias Schick, Melanie Bewerunge‐Hudler, Christian Mawrin, Marcel Seiz‐Rosenhagen, Ralf Ketter, Matthias Simon, Manfred Westphal, Katrin Lamszus, Albert J. Becker, Arend Koch, Jens Schittenhelm, Elisabeth J. Rushing, V. Peter Collins, Stefanie Brehmer, Lukas Chávez, Michael Platten, Daniel Hänggi, Andreas Unterberg, Werner Paulus, Wolfgang Wick, Stefan M. Pfister, Michel Mittelbronn, Matthias Preusser, Christel Herold‐Mende, Michael Weller, Andreas von Deimling,
Background The WHO classification of brain tumours describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. Grading is based solely on histology, with an absence of molecular markers. Although the existing classification and grading approach is of prognostic value, it harbours shortcomings such as ill-defined parameters for subtypes and grading criteria prone to arbitrary judgment. In this study, we aimed for a comprehensive ...
Tópico(s): Pituitary Gland Disorders and Treatments
2017 - Elsevier BV | The Lancet Oncology
... such as Otto Dix, George Grosz, Pablo Picasso, Georg Schrimpf, Joan Miró, and Alexander Kanoldt. In attempting to ...
Tópico(s): Latin American Literature Studies
2022 - University of Illinois Press | Journal of Film and Video
Die Bilder von Georg Schrimpf strahlen eine ungeheure Ruhe aus — diese steht im Gegensatz zu seinem rastlosen Wanderleben. Der Autodidakt eignete sich einen ganz ...
Tópico(s): Art, Aesthetics, and Perception
2016 - Springer Science+Business Media | Pädiatrie
Nagarajan Paramasivam, Daniel Hübschmann, Umut H. Toprak, Naveed Ishaque, Marian C. Neidert, Daniel Schrimpf, Damian Stichel, David Reuß, Philipp Sievers, Annekathrin Reinhardt, Annika K. Wefers, David Jones, Zuguang Gu, Johannes Werner, Sebastian Uhrig, Hans‐Georg Wirsching, Matthias Schick, Melanie Bewerunge‐Hudler, Katja Beck, Stephanie Brehmer, Steffi Urbschat, Marcel Seiz‐Rosenhagen, Daniel Hänggi, Christel Herold‐Mende, Ralf Ketter, Roland Eils, Zvi Ram, Stefan M. Pfister, Wolfgang Wick, Michael Weller, Rachel Grossmann, Andreas von Deimling, Matthias Schlesner, Felix Sahm,
DNA methylation patterns delineate clinically relevant subgroups of meningioma. We previously established the six meningioma methylation classes (MC) benign 1–3, intermediate A and B, and malignant. Here, we set out to identify subgroup-specific mutational patterns and gene regulation. Whole genome sequencing was performed on 62 samples across all MCs and WHO grades from 62 patients with matched blood control, including 40 sporadic meningiomas and 22 meningiomas arising after radiation (Mrad). RNA ...
Tópico(s): Neuroendocrine Tumor Research Advances
2019 - Springer Science+Business Media | Acta Neuropathologica
Philipp Sievers, Damian Stichel, Thomas Hielscher, Daniel Schrimpf, Annekathrin Reinhardt, Annika K. Wefers, David Reuß, David Jones, Melanie Bewerunge‐Hudler, Christian Hartmann, Peter Baumgarten, Hans‐Georg Wirsching, Bjarne Winther Kristensen, Benjamin Brokinkel, Ralf Ketter, Miguel Á. Idoate, Katrin Lamszus, Marcel Seiz‐Rosenhagen, Christian Mawrin, Patrick N. Harter, Jörg Felsberg, Daniel Hänggi, Christel Herold‐Mende, Anna S. Berghoff, Michael Weller, Stefan M. Pfister, Wolfgang Wick, Guido Reifenberger, Matthias Preusser, Andreas von Deimling, Felix Sahm,
Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00401-018-1924-x) contains supplementary material, which is available to authorized users.
Tópico(s): Cerebral Venous Sinus Thrombosis
2018 - Springer Science+Business Media | Acta Neuropathologica
Hans‐Georg Wirsching, Ghazaleh Tabatabai, Ulrich Roelcke, Andreas F. Hottinger, Francisca Jörger, Andrea Schmid, Ludwig Plaßwilm, Daniel Schrimpf, Christoph Mancao, David Capper, Katrin Conen, Thomas Hundsberger, Francesca Caparrotti, Roger von Moos, Christian Riklin, Jörg Felsberg, Patrick Roth, David Jones, Stefan M. Pfister, Elisabeth J. Rushing, Lauren E. Abrey, Guido Reifenberger, Leonhard Held, Andreas von Deimling, Adrian F. Ochsenbein, Michael Weller,
BackgroundThe addition of bevacizumab to temozolomide-based chemoradiotherapy (TMZ/RT → TMZ) did not prolong overall survival (OS) in patients with newly diagnosed glioblastoma in phase III trials. Elderly and frail patients are underrepresented in clinical trials, but early reports suggested preferential benefit in this population.Patients and methodsARTE was a 2 : 1 randomized, multi-center, open-label, non-comparative phase II trial of hypofractionated RT (40 Gy in 15 fractions) with bevacizumab (10 ...
Tópico(s): Nanoplatforms for cancer theranostics
2018 - Elsevier BV | Annals of Oncology
Sybren L. N. Maas, Damian Stichel, Thomas Hielscher, Philipp Sievers, Anna S. Berghoff, Daniel Schrimpf, Martin Sill, Philipp Euskirchen, Christina Blume, Areeba Patel, Helin Dogan, David Reuß, Hildegard Dohmen, Marco Stein, Annekathrin Reinhardt, Abigail K. Suwala, Annika K. Wefers, Peter Baumgarten, Franz Ricklefs, Elisabeth J. Rushing, Melanie Bewerunge‐Hudler, Ralf Ketter, Jens Schittenhelm, Zane Jaunmuktane, Severina Leu, Fay Greenway, Leslie R. Bridges, Timothy L. Jones, Conor Grady, Jonathan Serrano, John G. Golfinos, Chandranath Sen, Christian Mawrin, Ho‐Keung Ng, Daniel Hänggi, Manfred Westphal, Katrin Lamszus, Nima Etminan, Gerhard Jungwirth, Christel Herold‐Mende, Andreas Unterberg, Patrick N. Harter, Hans‐Georg Wirsching, Marian C. Neidert, Miriam Ratliff, Michael Platten, Matija Snuderl, Kenneth Aldape, Sebastian Brandner, Jürgen Hench, Stephan Frank, Stefan M. Pfister, David Jones, Guido Reifenberger, Till Acker, Wolfgang Wick, Michael Weller, Matthias Preusser, Andreas von Deimling, Felix Sahm,
Meningiomas are the most frequent primary intracranial tumors. Patient outcome varies widely from benign to highly aggressive, ultimately fatal courses. Reliable identification of risk of progression for individual patients is of pivotal importance. However, only biomarkers for highly aggressive tumors are established (CDKN2A/B and TERT), whereas no molecularly based stratification exists for the broad spectrum of patients with low- and intermediate-risk meningioma.DNA methylation data and copy-number ...
Tópico(s): Head and Neck Surgical Oncology
2021 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Philipp Sievers, Sonali Arora, Thomas Hielscher, D. Savran, Daniel Schrimpf, Rouzbeh Banan, David Vonhören, Stefan Pusch, Martin Sill, Romain Appay, Hans‐Georg Wirsching, Tibor Hortobágyi, Hildegard Dohmen, Till Acker, Patricia Kohlhof‐Meinecke, Leonille Schweizer, Annika K. Wefers, Patrick N. Harter, Christian Hartmann, Rudi Beschorner, Jens Schittenhelm, Felix Behling, Ghazaleh Tabatabai, Christian Mawrin, Matija Snuderl, Sybren L. N. Maas, Pieter Wesseling, Sebastian Brandner, Andrey Korshunov, Miriam Ratliff, Sandro M. Krieg, Wolfgang Wick, David Jones, Stefan M. Pfister, Eric C. Holland, Andreas von Deimling, Frank Szulzewsky, Felix Sahm,
Tópico(s): Neurofibromatosis and Schwannoma Cases
2025 - Oxford University Press | Neuro-Oncology
Heinrich Meyer, Georg Bangen, Hans-Egon Hass, Herbert Singer, Hellmut Rosenfeld, Karl Philipp Moritz, Hans Joachim Schrimpf,
Tópico(s): Linguistic Education and Pedagogy
1963 - Wiley | The German Quarterly
Michael Weller, Ghazaleh Tabatabai, Ulrich Roelcke, Andreas F. Hottinger, Francisca Joerger, Andrea Schmid, Ludwig Plaßwilm, Daniel Schrimpf, Christoph Mancao, David Capper, Katrin Conen, Thomas Hundsberger, Francesca Caparrotti, Roger von Moos, Christian Riklin, Jörg Felsberg, Patrick Roth, David Jones, Stefan M. Pfister, Elisabeth J. Rushing, Lauren E. Abrey, Guido Reifenberger, Leonhard Held, Andreas von Deimling, Adrian F. Ochsenbein, Hans‐Georg Wirsching,
The addition of bevacizumab to temozolomide-based chemoradiotherapy (TMZ/RT→TMZ) prolonged progression-free survival (PFS), but not overall survival (OS) in patients with newly diagnosed glioblastoma in two double-blind phase III trials. Elderly and frail patients are underrepresented in most clinical trials, but early reports of bevacizumab in glioblastoma suggested preferential benefit in this population. ARTE was a 2:1 randomized, multi-center, open-label trial of hypofractionated RT (40 Gy in 15 ...
Tópico(s): Cancer Treatment and Pharmacology
2017 - Oxford University Press | Neuro-Oncology
... Günther, Helmut Koopmann, Peter Pütz and Hans Joachim Schrimpf. Merigarto. Eine philologisch‐historische Monographie . By N. Th. ...
1978 - Wiley | German Life and Letters
... the attentions of Benno von Wiese, Hans Joachim Schrimpf, and H. B. Nisbet among others, has remained ...
2008 - Modern Humanities Research Association | The Modern Language Review
Sybren L. N. Maas, Damian Stichel, Thomas Hielscher, Philipp Sievers, Anna S. Berghoff, Daniel Schrimpf, Martin Sill, Philipp Euskirchen, David Reuß, Hildegard Dohmen, Marco Stein, Peter Baumgarten, Franz Ricklefs, E J Rushing, Melanie Bewerunge‐Hudler, Ralf Ketter, Jens Schittenhelm, Zane Jaunmuktane, Severina Leu, Conor Grady, Jonathan Serrano, John G. Golfinos, Chandranath Sen, Christian Mawrin, Ho‐Keung Ng, Daniel Hänggi, Manfred Westphal, Katrin Lamszus, Nima Etminan, Andreas Unterberg, Patrick N. Harter, Hans‐Georg Wirsching, Marian C. Neidert, Miriam Ratliff, Michael Platten, Matija Snuderl, Kenneth Aldape, Sebastian Brandner, Jürgen Hench, Stephan Frank, Stefan M. Pfister, David Jones, Guido Reifenberger, Till Acker, Wolfgang Wick, Michael Weller, Matthias Preusser, Andreas von Deimling, Felix Sahm,
Abstract PURPOSE Meningiomas are the most frequent primary intracranial tumors. Patient outcome varies widely from cases with benign to highly aggressive, ultimately fatal courses. Reliable identification of risk of progression for the individual patient is of pivotal importance in clinical management. However, only biomarkers for highly aggressive tumors are established at present (CDKN2A/B and TERT), while no molecularly-based stratification exists for the broad spectrum of low- and intermediate- ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2021 - Oxford University Press | Neuro-Oncology