George S. Stergiou, Angeliki Ntineri, Αναστάσιος Κόλλιας,
... Issue George S. Stergiou, Angeliki Ntineri and Anastasios Kollias George S. StergiouGeorge S. Stergiou From the Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece. , Angeliki NtineriAngeliki Ntineri From the Hypertension Center, Third University Department of Medicine, Sotiria Hospital, Athens, Greece. and Anastasios KolliasAnastasios Kollias From the Hypertension Center, Third University Department of ...
Tópico(s): Heart Rate Variability and Autonomic Control
2014 - Lippincott Williams & Wilkins | Hypertension
George S. Stergiou, N. Boubouchairopoulou, Αναστάσιος Κόλλιας,
... Perspectives George S. Stergiou, Nadia Boubouchairopoulou and Anastasios Kollias George S. StergiouGeorge S. Stergiou From the Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece. , Nadia BoubouchairopoulouNadia Boubouchairopoulou From the Hypertension Center STRIDE-7, National and Kapodistrian University of Athens, School of Medicine, Third Department of Medicine, Sotiria Hospital, Athens, Greece. and Anastasios KolliasAnastasios Kollias From the Hypertension Center STRIDE-7, National and ...
Tópico(s): Non-Invasive Vital Sign Monitoring
2017 - Lippincott Williams & Wilkins | Hypertension
Αναστάσιος Κόλλιας, George S. Stergiou, Konstantinos G. Kyriakoulis, Grzegorz Bilo, Gianfranco Parati,
... Improve PrognosisIs Amlodipine the Drug of Choice? Anastasios Kollias, George S. Stergiou, Konstantinos G. Kyriakoulis, Grzegorz Bilo and Gianfranco Parati Anastasios KolliasAnastasios Kollias From the Department of Cardiovascular, Neural and Metabolic ...
Tópico(s): Heart Rate Variability and Autonomic Control
2017 - Lippincott Williams & Wilkins | Hypertension
Dimitris L. Kontoyiannis, Alexey Kotlyarov, Ester Carballo, Lena Alexopoulou, Perry J. Blackshear, Matthias Gaestel, Roger J. Davis, Richard A. Flavell, George Kollias,
... Search for more papers by this author George Kollias Corresponding Author George Kollias Institute of Immunology, BSRC 'Alexander Fleming', 166 ... Search for more papers by this author George Kollias Corresponding Author George Kollias Institute of Immunology, BSRC 'Alexander Fleming', 166 72 ... Blackshear3, Matthias Gaestel2, Roger Davis5, Richard Flavell4 and George Kollias 1 1Institute of Immunology, BSRC 'Alexander Fleming', 166 ...
Tópico(s): Immune Response and Inflammation
2001 - Springer Nature | The EMBO Journal
Konstantin Nikolaou, Ageliki Tsagaratou, Christina Eftychi, George Kollias, George Mosialos, Iannis Talianidis,
The tumor suppressor cylindromatosis (CYLD) inhibits the NFκB and mitogen-activated protein kinase (MAPK) activation pathways by deubiquitinating upstream regulatory factors. Here we show that liver-specific disruption of CYLD triggers hepatocyte cell death in the periportal area via spontaneous and chronic activation of TGF-β activated kinase 1 (TAK1) and c-Jun N-terminal kinase (JNK). This is followed by hepatic stellate cell and Kupffer cell activation, which promotes progressive fibrosis, inflammation, ...
Tópico(s): Ubiquitin and proteasome pathways
2012 - Cell Press | Cancer Cell
Dimitris J. Panagopoulos, Panayiotis Victoratos, Maria Alexiou, George Kollias, George Mosialos,
There is much evidence, based primarily on in vitro studies, indicating that the Epstein-Barr virus oncoprotein latent membrane protein 1 (LMP1) mimics an activated CD40 receptor. In order to investigate the extent of similarity between LMP1 and CD40 functions in vivo, we analyzed the cytoplasmic signaling properties of LMP1 and CD40 in B cells in a directly comparable manner. For this purpose, we generated transgenic mice expressing either LMP1 or a chimeric LMP1CD40 molecule, which constitutively ...
Tópico(s): Eosinophilic Disorders and Syndromes
2004 - American Society for Microbiology | Journal of Virology
G. Kollias, Theofanis Giannopoulos,
... Histiocytoma of the Kidney: Report of a Case George Kollias, and Theofanis Giannopoulos George KolliasGeorge Kollias More articles ... Urological Association Education and Research, Inc.MetricsAuthor Information George Kollias More articles by this author Theofanis Giannopoulos More ...
Tópico(s): Renal and related cancers
1987 - Lippincott Williams & Wilkins | The Journal of Urology
Keila V. Sydenstricker, André A. Dhondt, Dana M. Hawley, Christopher S. Jennelle, Heidi W. Kollias, George V. Kollias,
The use of controlled, horizontal-transmission experiments provides detailed information on the spread of disease within fixed social groups, which informs our understanding of disease dynamics both in an empirical and theoretical context. For that reason, we characterized in 2002, horizontal transmission of Mycoplasma gallisepticum (MG) in two flocks of 11 wild-caught house finches housed in outdoor aviaries over a 6-mo period. All birds were initially free of MG by a polymerase chain reaction (PCR)- ...
Tópico(s): Viral Infections and Vectors
2006 - American Association of Avian Pathologists | Avian Diseases
Christos Papaneophytou, Polyxeni Alexiou, Athanasios Papakyriakou, Evangelos Ntougkos, Katerina Tsiliouka, Anna Maranti, Fotini Liepouri, A. T. Strongilos, Anthi Mettou, Elias A. Couladouros, Elias Eliopoulos, Eleni Douni, George Kollias, George Kontopidis,
A series of 39 novel SPD-304 analogs were designed synthesized and evaluated as inhibitors of TNF.
Tópico(s): Cytokine Signaling Pathways and Interactions
2015 - Royal Society of Chemistry | MedChemComm
Charikleia S. Vrettou, Lampis C. Stavrinou, Spyridon Halikias, Magdalini Kyriakopoulou, Spyridon Kollias, George Stranjalis, Antonia Koutsoukou,
Tópico(s): Acute Ischemic Stroke Management
2009 - Springer Science+Business Media | Acta Neurochirurgica
Nikiforos Kollias, George Zonios, Georgios N. Stamatas,
The fluorescence properties of skin both human and of an animal model are reviewed in this article. Fluorescence spectroscopy is a valuable tool for the investigation of the optical properties of the skin in the ultraviolet range of the spectrum because the absorption bands are confluent. Epidermal and dermal fluorescence signals are each produced in distinct spectral regions. Biological processes modulate the fluorescence signals in predictable ways. Such cases include aging, epidermal proliferation, ...
Tópico(s): melanin and skin pigmentation
2002 - Elsevier BV | Vibrational Spectroscopy
Pavlos Kollias, George Tselioudis, Bruce A. Albrecht,
Long‐term (6.5 years) cloud observations from the Atmospheric Radiation Measurements (ARM) program Southern Great Plains (SGP) climate research facility in Oklahoma are used to develop detailed cloud climatology. Clouds are classified with respect to their altitude (low, middle, and high), vertical development, and the presence of multilayer clouds. Single‐layered cirrus, middle or low clouds were observed a total of 23% of the time the MilliMeter Cloud Radar (MMCR) was operating, and multilayer clouds ...
Tópico(s): Atmospheric Ozone and Climate
2007 - American Geophysical Union | Journal of Geophysical Research Atmospheres
Chengxiang Fan, Michael A. Luedtke, Stephen M. Prouty, Michelle Burrows, Nikiforos Kollias, George Cotsarelis,
Background: In vivo confocal scanning laser microscopy (CSLM) is a recently developed non‐invasive technique for visualizing microscopic structures with the skin. CSLM has been used to characterize proliferative and inflammatory skin diseases, neoplastic skin lesions and pigmented lesions. Objective: Here, we assessed the ability of CSLM to evaluate the formation of neogenic hair follicles after a full‐thickness wound in mice. Methods: Full‐thickness wounds were made on the dorsal skin of 3‐week‐ ...
Tópico(s): Cancer and Skin Lesions
2011 - Wiley | Skin Research and Technology
Christos Kollias, George Manolas, Suzanna‐Maria Paleologou,
This paper examines the relationship between military expenditure and growth among the EU15 members using co-integration and causality tests for the period 1961–2000. Although the results reported herein do not reveal a uniformity among the 15 countries, the apparent prevalence of the direction of causality from growth to military expenditure as well as the absence of the reverse causal ordering may be an indication that an important number of governments in the European Union (EU) make defence spending ...
Tópico(s): Economic Growth and Productivity
2004 - Elsevier BV | Journal of Policy Modeling
Christos Kollias, George Manolas, Suzanna-Maria Paleologouc,
Greece has over the years allocated substantial human and material resources to defence. Its defence burden (i.e. military expenditure as a share of GDP) has invariably been substantially higher than the EU and NATO averages. Furthermore, during the post-bipolar period, when the defence budgets of most countries shrunk, Greek defence spending grew in real terms. This paper contributes to the existing literature on Greek defence spending and its effects by empirically estimating the impact of such ...
Tópico(s): Fiscal Policy and Economic Growth
2004 - Taylor & Francis | Defence and Peace Economics
V.P. Kontaxakis, B.J. Havaki-Kontaxaki, Maria Margariti, S.S. Stamouli, Costas T. Kollias, George N. Christodoulou,
Schizophrenia has been associated with a high rate of suicide. This study investigates the prevalence of suicidal ideation in a population of inpatients with acute schizophrenia, together with the clinical parameters associated with suicidal thoughts.We assessed 93 schizophrenia patients. We matched subjects for age and sex and compared subjects with and without suicidal thoughts. We performed stepwise multiple regression analysis to assess the association between specific clinical symptoms and ...
Tópico(s): Mental Health and Psychiatry
2004 - SAGE Publishing | The Canadian Journal of Psychiatry
George Kollias, Eleni Douni, George Kassiotis, Dimitris L. Kontoyiannis,
There is now good evidence to demonstrate that aberrations in tumour necrosis factor (TNF) production in vivo may be either pathogenic or protective and several plausible mechanisms may explain these contrasting activities. According to the classic pro-inflammatory scenario, failure to regulate the production of TNF at a site of immunological injury may lead to chronic activation of innate immune cells and to chronic inflammatory responses, which may consequently lead to organ specific inflammatory ...
Tópico(s): Immunotherapy and Immune Responses
1999 - BMJ | Annals of the Rheumatic Diseases
George Kollias, Eleni Douni, George Kassiotis, Dimitris L. Kontoyiannis,
Summary: The specific role of the tumor necrosis factor (TNF)/TNF receptor (TNFR) system in disease pathogenesis still remains an unresolved puzzle. Recent studies in transgenic and knockout animals, where the pathogenic influence of genetically perturbed TNF expression has been evaluated, indicate that several pathways of TNF/TNFR action may contribute independently or in concert to initiate, promote or downregulate disease pathogenesis. Evidently, organ‐specific inflammatory or autoimmune pathology ...
Tópico(s): Rheumatoid Arthritis Research and Therapies
1999 - Wiley | Immunological Reviews
George S. Stergiou, Αναστάσιος Κόλλιας, Nikos Karpettas,
... Oscillometric Blood Pressure Measurement? George S. Stergiou, Anastasios Kollias and Nikos Karpettas George S. StergiouGeorge S. Stergiou Hypertension Center, Third University Department of Medicine, Sotiria Hopsital, Athens, Greece , Anastasios KolliasAnastasios Kollias Hypertension Center, Third University Department of Medicine, Sotiria ...
Tópico(s): Heart Rate Variability and Autonomic Control
2013 - Lippincott Williams & Wilkins | Hypertension
Frank Grosveld, Greet Blom van Assendelft, David R. Greaves, George Kollias,
We have constructed a “minilocus” that contains the 5′ and 3′ flanking regions of the human β-globin locus and the β-globin gene. These regions are characterized by erythroid-specific DNAase I-superhypersensitive sites and are normally located approximately 50 kb 5′ and 20 kb 3′ of the β-globin gene. This minilocus is expressed tissue-specifically in transgenic mice at a level directly related to its copy number yet independent of its position of integration in the genome. Moreover, the expression ...
Tópico(s): Animal Genetics and Reproduction
1987 - Cell Press | Cell
George Kollias, David J. Evans, Mary A. Ritter, J. N. Beech, Roger J. Morris, Frank Grosveld,
Tópico(s): Biochemical and Molecular Research
1987 - Cell Press | Cell
George Kollias, Eugenia Spanopoulou, Frank Grosveld, M. A. Ritter, J. N. Beech, Richard J. Morris,
We have generated Thy-1.1-transgenic Thy-1.2 mice to study the developmental expression of the Thy-1 gene in detail by transcriptional and immunological methods. In brain, the expression of the injected gene was identical to that of the endogenous gene in a tissue- and development-specific manner. In lymphoid tissue, the transferred gene was also expressed correctly in the early phases of T-cell lineage development; however, as the T cells matured, the transcription of the transferred gene, but ...
Tópico(s): RNA and protein synthesis mechanisms
1987 - National Academy of Sciences | Proceedings of the National Academy of Sciences
George Kollias, J. Hurst, E. deBoer, Frank Grosveld,
The human β-globin gene is part of a multigene fsmily and is expressed specifically in adult human erythroid tissue (for review, 1). When the human β-globin is introduced into fertilized mouse eggs, it is first activated in foetal liver and remains expressed in adult erythroid tissues (2,3,4). It therefore mimicks the pattern of expression of its murine counterpart. It has previously been shown in tissue culture (5) and transgenic mice (4) that sequences downstream from the β-globin promoter are involved ...
Tópico(s): Genomics and Chromatin Dynamics
1987 - Oxford University Press | Nucleic Acids Research
George Kollias, Nick Wrighton, J. Hurst, Frank Grosveld,
We have introduced the human fetal γ- and adult β-globin genes into the germ line of mice. Analysis of the resulting transgenic mice shows that the human γ-globin gene is expressed like an embryonic mouse globin gene; the human β-globin gene is expressed (as previously shown) like an adult mouse globin gene. These results imply that the regulatory signals for tissue- and developmental stage-specific expression of the globin genes have been conserved between man and mouse but that the timing of the ...
Tópico(s): RNA and protein synthesis mechanisms
1986 - Cell Press | Cell
Frank Grosveld, George Kollias,
Hybrid human--mouse Thy-1.1 genes were injected into pronuclei of Thy-1.2 mice to produce transgenic animals. A hybrid gene composed of the 5' part of the mouse Thy-1.1 gene combined with the 3' human untranslated regions was expressed abnormally in the kidney podocytes, which resulted in severe protein-uria and subsequent death in several founder mice. A hybrid Thy-1 gene composed of the human coding region with the 5' and 3' flanking regions of the mouse gene was expressed abnormally in a different ...
Tópico(s): Renal and related cancers
1988 - Cell Press | Cell
Claus Johansen, Christian Vestergaard, Knud Kragballe, George Kollias, Matthias Gaestel, Lars Iversen,
The association between inflammation and tumorigenesis is well recognized. Mitogen-activated protein kinase-activated protein kinase-2 (MK2) is known to play a pivotal role in inflammatory processes. Here, we studied the effect of MK2 -deficiency and tumor necrosis factor ( TNF )-α-deficiency on skin tumor development in mice using the two-stage chemical carcinogenesis model. We found that MK2 −/− mice developed significantly fewer skin tumors compared with both TNF -α −/− and wild-type mice when induced by initiation ...
Tópico(s): Cancer-related Molecular Pathways
2009 - Oxford University Press | Carcinogenesis
Antreas Afantitis, Georgia Melagraki, Haralambos Sarimveis, Panayiotis A. Koutentis, Olga Igglessi‐Markopoulou, George Kollias,
Tópico(s): Chemical Synthesis and Analysis
2009 - Springer Science+Business Media | Molecular Diversity
Panayiotis Victoratos, George Kollias,
Follicular dendritic cells (FDCs) are important for the induction of protective T cell-dependent humoral responses, but their contribution to autoimmunity remains elusive. Here, gene-targeted interruption of FDC development was combined with the K/BxN mouse model of arthritis. We found that FDCs were essential for autoantibody production through two distinct but cooperative functions. In a T cell-independent fashion, FDCs loaded with autoantigen-containing immune complexes supported germinal center ( ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2009 - Cell Press | Immunity
Marietta Armaka, Vasiliki Gkretsi, Dimitris L. Kontoyiannis, George Kollias,
Tópico(s): Rheumatoid Arthritis Research and Therapies
2009 - Springer Nature | Protocol Exchange
Kellie A. Charles, Hagen Kulbe, Robin Soper, Monica Wang, Toby Lawrence, Anne M. Schultheis, Probir Chakravarty, Richard G. Thompson, George Kollias, John F. Smyth, Frances R. Balkwill, Thorsten Hagemann,
Cytokines orchestrate the tumor-promoting interplay between malignant cells and the immune system. In many experimental and human cancers, the cytokine TNF-alpha is an important component of this interplay, but its effects are pleiotropic and therefore remain to be completely defined. Using a mouse model of ovarian cancer in which either TNF receptor 1 (TNFR1) signaling was manipulated in different leukocyte populations or TNF-alpha was neutralized by antibody treatment, we found that this inflammatory ...
Tópico(s): Immune Response and Inflammation
2009 - American Society for Clinical Investigation | Journal of Clinical Investigation