Produção Nacional
Revisado por pares
Milena Barcza Stockler‐Pinto, Olaf Malm, Suellen Regina Geraldo Azevedo, Najla Elias Farage, Paulo R. Dorneles, Sílvia Maria Franciscato Cozzolino, Denise Mafra,
Introduction: Patients with chronic kidney disease present selenium (Se) plasma deficiency which is an essential trace element with important biological functions and, the best known biological role is attributed to its presence in the antioxidant enzyme, glutathione peroxidase (GPx). The Se content of foods depends on soil and some authors have suggested that Amazon soil (North Brazilian region) has high Se concentrations when compared to other regions of Brazil. Objective: The objective of this work ...
Tópico(s): Trace Elements in Health
2014 - Sociedade Brasileira de Nefrologia | Brazilian Journal of Nephrology
Produção Nacional
Revisado por pares
Kênia Soares de Souza, Thiago A. Cantaruti, Geraldo Magela Azevedo, Daniel Antero de Almeida Galdino, Claudiney Melquíades Rodrigues, Raquel Alves Costa, Nelson M. Vaz, Cláudia R. Carvalho,
Skin wound healing is a complex process involving many types of cells and molecules and often results in scar tissue formation in adult mammals. However, scarless healing occurs in foetal skin and minimal scars may occur after cutaneous healing in the adult with reduced inflammation. Alpha-melanocyte-stimulating hormone (α-MSH) is widely distributed within the central nervous system and in other body regions, such as the skin, and has strong anti-inflammatory activity. The aim in the present experiments ...
Tópico(s): Skin Protection and Aging
2014 - Wiley | Experimental Dermatology
Produção Nacional
Revisado por pares
Raquel Alves Costa, Valéria Ruiz‐de‐Souza, Geraldo Magela Azevedo, Elisandra Gava, Gregory T. Kitten, Nelson M. Vaz, Cláudia R. Carvalho,
ABSTRACT Tissue injury in adult mammalian skin frequently results in scarring while fetal mammalian skin heals with complete regeneration. Inflammatory reactions are among the factors thought to impair regeneration. Previous studies have shown that the injection of an immunologically tolerated protein blocks immune responses to unrelated antigens and is also able to inhibit inflammation in mice. This phenomenon, which we refer to as the indirect effects of oral tolerance, does not require the simultaneous ...
Tópico(s): Tendon Structure and Treatment
2011 - Wiley | Wound Repair and Regeneration
Produção Nacional
Geraldo Magela Azevedo, Raquel Alves Costa, Mariana Araujo Resende, Claudiney Melquíades Rodrigues, Nelson M. Vaz, Cláudia R. Carvalho,
Parenteral injection of tolerated proteins into orally tolerant mice inhibits the initiation of immunological responses to unrelated proteins and blocks severe chronic inflammatory reactions of immunological origin, such as autoimmune reactions. This inhibitory effect which we have called “indirect effects of oral tolerance” is also known as “bystander suppression.” Herein, we show that i.p. injection of OVA + Al(OH) 3 minutes before i.v. injection of Schistosoma mansoni eggs into OVA tolerant mice ...
Tópico(s): Drug-Induced Hepatotoxicity and Protection
2011 - Hindawi Publishing Corporation | Clinical and Developmental Immunology
Produção Nacional
Revisado por pares
Raquel Alves Costa, Valéria Ruiz‐de‐Souza, Geraldo Magela Azevedo, N.M. Vaz, Cláudia R. Carvalho,
Round holes in the ears of MRL mice tend to close with characteristics of regeneration believed to be absent in other mouse strains (e.g., C57BL/6). We evaluated the kinetics and the histopathology of ear wound closure in young (8 weeks old) C57BL/6 and BALB/c mice. We also used middle-aged (40 weeks old) C57BL/6 mice to evaluate the influence of aging on this process. A circular through-and-through hole was made in the ear, photographs were taken at different times after injury and wound area was ...
Tópico(s): Surgical Sutures and Adhesives
2009 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Revisado por pares
Gustavo C. Ramos, Claudiney Melquíades Rodrigues, Geraldo Magela Azevedo, Vanessa Pinho, Cláudia R. Carvalho, Nelson M. Vaz,
Oral tolerance promotes a generalized decrease in specific immune responsiveness to proteins previously encountered via the oral route. In addition, parenteral immunization with a tolerated protein also triggers a significant reduction in the primary responsiveness to a second unrelated antigen. This is generally explained by 'innocent bystander suppression', suggesting that the transient and episodic effects of inhibitory cytokines released by contact with the tolerated antigen would block responses ...
Tópico(s): Neuropeptides and Animal Physiology
2008 - Wiley | Immunology
Produção Nacional
Revisado por pares
Rosângela Teixeira, Maria das Dores Ferreira, Paulo Marcos Zech Coelho, Geraldo Brasileiro Filho, Geraldo Magela Azevedo, J R Lambertucci,
Three children with acute schistosomiasis mansoni developed pyogenic liver abscesses. The abscesses were diagnosed by ultrasonography and confirmed during laparotomy. Staphylococcus aureus were the sole bacteria isolated from the abscesses. An experimental study was carried out in mice to establish whether schistosomiasis is a predisposing cause for pyogenic liver abscesses. Seventeen mice (group 1) were infected with 40 Schistosoma mansoni cercariae (LE strain) and 60 d later inoculated intravenously ...
Tópico(s): Appendicitis Diagnosis and Management
1996 - Oxford University Press | Transactions of the Royal Society of Tropical Medicine and Hygiene
Produção Nacional
Revisado por pares
Delma Aurélia da Silva Simão, Elenice Dias Ribeiro de Paula Lima, Raíssa Silva Souza, Tiago Vitervo Faria, Geraldo Fernandes Azevedo,
Objetivou-se relatar um caso de uma paciente que apresentou síndrome mão-pé de grau 3, decorrente do uso do quimioterápico Capecitabina e para a qual foi utilizada massagem local com creme hidratante aquoso à base de aloe vera. A capacidade funcional da paciente foi avaliada utilizando-se a Escala de Performance ECOG e as lesões fotografadas durante as consultas de enfermagem que ocorreram em intervalos de dez dias, totalizando quarenta dias de acompanhamento. Observou-se melhora significativa da ...
Tópico(s): Oral health in cancer treatment
2012 - Associação Brasileira de Enfermagem | Revista Brasileira de Enfermagem
Produção Nacional
Revisado por pares
Raffaella Bertoni Cavalcanti Teixeira, Paulo Marcos Zech Coelho, Geraldo Brasileiro Filho, Geraldo Magela Azevedo, José Carlos Serufo, Francis Jardim Pfeilsticker, F P Abreu, Cátia Costa, Giovanna DC Santa Cecília, José Roberto Lambertucci,
Schistosomiasis mansoni infection that occurs concurrently with Staphylococcus aureus bacteremia favors the formation of pyogenic liver abscess. The present experimental study in mice evaluated the following aspects of the relationship between infection with Schistosoma mansoni and liver abscess caused by S. aureus: a) the role of the eggs of S. mansoni in the genesis of the abscesses; b) the influence of different phases of schistosomiasis in the development of liver abscesses; and c) the effect ...
Tópico(s): Parasites and Host Interactions
2001 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Produção Nacional
Revisado por pares
Helena Carla Castro, Paula Alvarez Abreu, Reinaldo Barros Geraldo, Rita Cristina Azevedo Martins, Ruben dos Santos, Natália I.V. Loureiro, Lourdes Maria Corrêa Cabral, Carlos Rangel Rodrigues,
Abstract Proteases have received enormous interest from the research and medical communities because of their significant roles in several human diseases. Some examples include the involvement of thrombin in thrombosis, HIV‐1 protease in Acquired Immune Deficiency Syndrome, cruzain in Trypanosoma cruzi infection, and membrane‐type 1 matrix metalloproteinase in tumor invasion and metastasis. Many efforts has been undertaken to design effective inhibitors featuring potent inhibitory activity, specificity, ...
Tópico(s): Protease and Inhibitor Mechanisms
2011 - Wiley | Journal of Molecular Recognition
Produção Nacional
Revisado por pares
Sérvio Pontes Ribeiro, Wesley Dáttilo, David Soeiro Barbosa, Wendel Coura‐Vital, Igor Aparecido Santana das Chagas, Camila de Paula Dias, Alcides Castro e Silva, Maria Helena Franco Morais, Aristóteles Goés‐Neto, Vasco Azevedo, Geraldo Wilson Fernandes, Alexandre Barbosa Reis,
The spread of SARS-CoV-2 and the distribution of cases worldwide followed no clear biogeographic, climatic, or cultural trend. Conversely, the internationally busiest cities in all countries tended to be the hardest hit, suggesting a basic, mathematically neutral pattern of the new coronavirus early dissemination. We tested whether the number of flight passengers per time and the number of international frontiers could explain the number of cases of COVID-19 worldwide by a stepwise regression. Analysis ...
Tópico(s): COVID-19 Pandemic Impacts
2020 - Brazilian Academy of Sciences | Anais da Academia Brasileira de Ciências
Produção Nacional
Revisado por pares
Sérvio Pontes Ribeiro, Alcides Castro e Silva, Wesley Dáttilo, Alexandre Barbosa Reis, Aristóteles Goés‐Neto, Luíz Carlos Júnior Alcântara, Marta Giovanetti, Wendel Coura‐Vital, Geraldo Wilson Fernandes, Vasco Azevedo,
Background We investigated a likely scenario of COVID-19 spreading in Brazil through the complex airport network of the country, for the 90 days after the first national occurrence of the disease. After the confirmation of the first imported cases, the lack of a proper airport entrance control resulted in the infection spreading in a manner directly proportional to the amount of flights reaching each city, following the first occurrence of the virus coming from abroad. Methodology We developed a ...
Tópico(s): COVID-19 and Mental Health
2020 - PeerJ, Inc. | PeerJ
Produção Nacional
Revisado por pares
Rodrigo Palácio de Azevedo, Flávio Geraldo Resende Freitas, Elaine Maria Ferreira, Luciano César Pontes Azevedo, Flávia Ribeiro Machado,
Constipation is a common problem in intensive care units. We assessed the efficacy and safety of laxative therapy aiming to promote daily defecation in reducing organ dysfunction in mechanically ventilated patients.
Tópico(s): Esophageal and GI Pathology
2015 - BioMed Central | Critical Care
Produção Nacional
Revisado por pares
Simone Lombardi-Crestana, Mariana da Silva Azevedo, Geraldo Felipe Ferreira e Silva, Luís Pino, Beatriz Appezzato‐da‐Glória, Antônio Figueira, Fábio Tebaldi Silveira Nogueira, Lázaro Eustáquio Pereira Peres,
Despite the wide use of plant regeneration for biotechnological purposes, the signals that allow cells to become competent to assume different fates remain largely unknown. Here, it is demonstrated that the Regeneration1 (Rg1) allele, a natural genetic variation from the tomato wild relative Solanum peruvianum, increases the capacity to form both roots and shoots in vitro; and that the gibberellin constitutive mutant procera (pro) presented the opposite phenotype, reducing organogenesis on either ...
Tópico(s): Plant Reproductive Biology
2012 - Oxford University Press | Journal of Experimental Botany
Produção Nacional
Revisado por pares
Francisco Santos, Eduardo Bessa Azevedo, Geraldo L. Sant’Anna, Márcia Dezotti,
Photocatalysis has been used as tertiary treatment for petroleum refinery wastewaters to comply with the regulatory discharge limits and to oxidize persistent compounds that had not been oxidized in the biological treatment. The wastewater is generated by the refinery and directly discharged into the Guanabara Bay (Rio de Janeiro). Although BOD removal is high, a residual and persistent COD, besides a somewhat high phenol content remains. Three photocatalysts were tested - TiO2 (Aldrich), ZnO (Aldrich), ...
Tópico(s): Water Quality Monitoring and Analysis
2006 - Springer Science+Business Media | Brazilian Journal of Chemical Engineering
Produção Nacional
Revisado por pares
Rafaeli Aparecida Vieira de Souza, Francyane Tavares Braga, Tesfahun Alemu Setotaw, João Vieira Neto, Patrícia Helena de Azevedo, V. H. de Azevedo, Geraldo Magela de Almeida Cançado,
The experiment was carried out to determine the appropriate dose of coconut water as supplement for in vitro cultivation of zygotic embryos from 19 olive genotypes. The isolated embryos of the olive seeds were immersed on culture medium containing 0 (control), 25, 50, and 100mL L-1 of fresh and sterile coconut water and kept for 45 days under controlled environment. The percentage of germination, shoot length, number of roots, number of leaves and number of internodes were measured for all 19 olive ...
Tópico(s): Plant Genetic and Mutation Studies
2013 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Produção Nacional
Revisado por pares
Daiane Dal Pai, Liana Lautert, Juliana Petri Tavares, Geraldo de Azevedo e Souza Filho, Rogério Alexandre Nedir Dornelles, Álvaro Roberto Crespo Merlo,
Os recentes incrementos tecnológicos promovidos junto ao serviço judiciário federal trouxeram avanços importantes para a melhoria dos atendimentos prestados à população, contudo originaram novas demandas organizacionais aos trabalhadores do setor. Objetivo Conhecer as repercussões da organização do trabalho no cotidiano laboral e na saúde dos servidores do Juizado Especial Federal de Porto Alegre (RS).Procedimentos metodológicos Desenvolveu-se uma pesquisa de abordagem qualitativa, por meio de entrevistas ...
Tópico(s): Education and Work Dynamics
2014 - UNIVERSIDADE DE SÃO PAULO | Saúde e Sociedade
Produção Nacional
Revisado por pares
Sérgio D. Simon, José Bines, Gustavo Werutsky, João Soares Nunes, Fernando Chalu Pacheco, J. G. M. Segalla, Andrea J.S. Gomes, Brigitte Marie H.R. Adam Van Eyll, Daniel Luiz Gimenes, Susanne Crocamo, Ruffo Freitas‐Júnior, Lissandra Dal Lago, Geraldo Silva Queiroz, Sérgio Jobim Azevedo, Daniela Dornelles Rosa, G. Delgado, Giuliano Santos Borges, Yeni Verônica do Nascimento, Facundo Zaffaroni, Jeovany Martínez-Mesa, Carlos H. Barrios,
To describe stage I-III breast cancer (BC) molecular subtypes and outcomes among a cohort of patients from Brazil.AMAZONA study is a retrospective cohort conducted from June 2008 to January 2009 including women of at least 18 years old, with histologically proven breast cancer, diagnosed in 2001 (n = 2198) and 2006 (n = 2714). In this analysis, we included patients who underwent surgery, had stage I-III disease and available pathological information (n = 2296). We estimated molecular subtypes by local immunohistochemical ...
Tópico(s): Global Cancer Incidence and Screening
2019 - Elsevier BV | The Breast
Produção Nacional
Revisado por pares
Edson Luiz de Lima, Geraldo Magela Salomé, Maria José Azevedo de Brito, Lydia Masako Ferreira,
Objective: To assess disability in patients with venous leg ulcers treated with compression therapy with Unna's boot. Method: A descriptive analytic case control study was conducted from June 2010 to May 2011 in an outpatient wound care clinic in interior Brazil. Fifty patients of both sexes, aged 18 years or above, who had had a venous leg ulcer for more than 1 year and a Doppler ankle-brachial index of 0.8–1.0 were selected for the study. Patients were treated with wound dressings and Unna's boot. ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2013 - Mark Allen Group | Journal of Wound Care
Produção Nacional
Maria Elisabeth Barros de Oliveira, Gerardo Sérgio Francelino de Oliveira, Geraldo Arraes Maia, Renato de Azevedo Moreira, A. C. De Oliveira Monteiro,
Visando a contribuir para o conhecimento dos aminoácidos livres majoritários presentes no suco de caju (Anacardium occidentale L.), estudou-se o seu comportamento ao longo da safra de 1995, no período de agosto a novembro, no clone de cajueiro-anão precoce, CCP 09, com aptidão para a produção de suco. O suco foi obtido de cajus cultivados no município de Pio IX, Estado do Piauí, Brasil. Os frutos foram colhidos em intervalos de 21 dias, perfazendo cinco amostragens. Os aminoácidos foram determinados ...
Tópico(s): Ginkgo biloba and Cashew Applications
2002 - Sociedade Brasileira de Fruticultura | Revista Brasileira de Fruticultura
Produção Nacional
Revisado por pares
Luiz Antonio F. da Silva, Wilkson Vilaça, D.A. Azevedo, Geraldo de Majella, Iede F. Silva, Benisio F. Silva,
Tópico(s): Cleft Lip and Palate Research
2009 - Elsevier BV | Forensic science international. Genetics supplement series
Produção Nacional
Revisado por pares
Laura Beatriz Batista de Melo, Bruno Montoani Silva, Devison Souza Peixoto, Thayná Pereira Azevedo Chiarini, Geraldo César de Oliveira, Nilton Curi,
Geophysical methods that allow determination of soil electrical resistivity (ρ) make estimates of the space-time variation of soil water content (θ) viable, as well as of other important physical properties and soil structure. The aims of this study were to test models for the θ-ρ relationship in a Typic Hapludox with clay texture under tropical conditions, and to determine the effect of the degree of compaction on this relationship. Undisturbed samples were collected and, in the laboratory, after ...
Tópico(s): Geophysical Methods and Applications
2020 - Elsevier BV | Soil and Tillage Research
Produção Nacional
Revisado por pares
Flávia Ribeiro Machado, Elaine Maria Ferreira, P Schippers, Ilusca Cardoso de Paula, Letícia Sandre Vendrame, Francisco Ivanildo de Oliveira, Paula Tuma, Wilson Nogueira Filho, Felipe Gonçalves Motta Maia, Sandra Guare, Cláudia Mangini, G Guth, Luciano César Pontes Azevedo, Flávio Geraldo Resende Freitas, José Luiz Gomes do Amaral, Nacime Salomão Barbachan Mansur, Reinaldo Salomão,
Public hospitals in emerging countries pose a challenge to quality improvement initiatives in sepsis. Our objective was to evaluate the results of a quality improvement initiative in sepsis in a network of public institutions and to assess potential differences between institutions that did or did not achieve a reduction in mortality.We conducted a prospective study of patients with sepsis or septic shock. We collected baseline data on compliance with the Surviving Sepsis Campaign 6-h bundles and ...
Tópico(s): Global Maternal and Child Health
2017 - BioMed Central | Critical Care
Produção Nacional
Revisado por pares
Òren Smaletz, Maria Del Pilar Estevez Diz, Claudio Calazan do Carmo, Jorge Sabbaga, Geraldo Felício Cunha-Junior, Sérgio Jobim Azevedo, Fernando Cotait Maluf, Carlos H. Barrios, R. L.R. Costa, Ana G. Fontana, Vivian Madrigal, Alberto Julius Alves Wainstein, Fernanda Perez Yeda, Venâncio Avancini Ferreira Alves, Ana Maria Moro, Roberto Blasbalg, Andrew M. Scott, Eric W. Hoffman,
The primary objective was to evaluate the clinical efficacy of hu3S193, a humanized monoclonal antibody against the Lewis-Y antigen, in patients with platinum resistant/refractory ovarian, fallopian tube and primary peritoneal carcinoma. Secondary objectives were safety and pharmacokinetics. In addition, we sought to determine the potential interaction of clinical benefit and patient characteristics.This two-stage, multicenter, single arm, phase II trial enrolled eligible patients to receive hu3S193 ...
Tópico(s): Uterine Myomas and Treatments
2015 - Elsevier BV | Gynecologic Oncology
Produção Nacional
Revisado por pares
Raquel C. S. Azevedo, Ricardo Geraldo de Sousa, W. A. A. Macedo, Edésia Martins Barros de Sousa,
Tópico(s): Nanopore and Nanochannel Transport Studies
2014 - Springer Science+Business Media | Journal of Sol-Gel Science and Technology
Produção Nacional
Revisado por pares
Ivo Santana Caldas, Paulo Marcos da Matta Guedes, Fabiane Matos dos Santos, Lívia de Figueiredo Diniz, Tassiane Assíria Fontes Martins, Álvaro Fernando da Silva do Nascimento, Maíra Araújo Azevedo, Wanderson Geraldo de Lima, Raimundo Marques do Nascimento Neto, Rosália Morais Tôrres, André Talvani, Maria Terezinha Bahia,
Abstract Objectives The cardiac form of Chagas disease is evidenced by a progressive cardiac inflammation that leads to myocarditis, fibrosis and electrocardiographic (ECG) conduction abnormalities. Considering these characteristics, the aim of this study was to prospectively evaluate the early ECG changes in dogs that were experimentally inoculated with Benznidazole (Bz)‐susceptibly (Berenice‐78) and Bz‐resistant (VL‐10, and AAS) Trypanosoma cruzi strains and, later, evaluate the efficacy of Bz treatment ...
Tópico(s): Vector-borne infectious diseases
2012 - Wiley | Tropical Medicine & International Health
Produção Nacional
Rodrigo Palácio de Azevedo, Flávio Geraldo Rezende Freitas, Elaine Maria Ferreira, Flávia Ribeiro Machado,
A constipação intestinal é uma complicação comumente identificada entre pacientes graves. Sua incidência é bastante variável devido à carência de uma definição aplicável a estes pacientes. Além das consequências já conhecidas da constipação, nos últimos anos tem-se percebido que essa complicação também pode estar relacionada ao pior prognóstico de pacientes críticos. Ao longo desta revisão procurou-se descrever as principais evidências científicas disponíveis mostrando ser a constipação um marcador ...
Tópico(s): Abdominal Surgery and Complications
2009 - Associação de Medicina Intensiva Brasileira | Revista Brasileira de Terapia Intensiva
Produção Nacional
Revisado por pares
João Frederico da Costa Azevedo Meyer, Geraldo L. Diniz,
Tópico(s): Groundwater flow and contamination studies
2006 - Elsevier BV | Ecological Modelling
Produção Nacional
Revisado por pares
Maria Alicia H. Navarrete, Carolina M. Maier, Roberto Falzoni, Luiz Gerk de Azevedo Quadros, Geraldo Rodrigues de Lima, Edmund Chada Baracat, Afonso CP Nazário,
Abstract Introduction During the menstrual cycle, the mammary gland goes through sequential waves of proliferation and apoptosis. In mammary epithelial cells, hormonal and non-hormonal factors regulate apoptosis. To determine the cyclical effects of gonadal steroids on breast homeostasis, we evaluated the apoptotic index (AI) determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) staining in human mammary epithelial cells during the spontaneous menstrual cycle ...
Tópico(s): Estrogen and related hormone effects
2005 - BioMed Central | Breast Cancer Research
Geraldo Lorenzi‐Filho, Eduardo Ribeiro de Azevêdo, John D. Parker, T. Douglas Bradley,
Hypocapnia contributes to the genesis of Cheyne-Stokes respiration and central sleep apnoea in patients with congestive heart failure (CHF) and is associated with increased mortality. However, the cause of hypocapnia in patients with chronic stable CHF is unknown. Since pulmonary congestion can induce hyperventilation via stimulation of pulmonary vagal afferents, the present study tested the hypothesis that in patients with CHF (carbon dioxide tension in arterial blood ( P a,CO 2 )) is inversely related ...
Tópico(s): Respiratory Support and Mechanisms
2002 - European Respiratory Society | European Respiratory Journal