Produção Nacional
Revisado por pares
Douglas Costa Gontijo, Maria Fernanda Alves do Nascimento, Geraldo Célio Brandão, Alaı́de Braga de Oliveira,
Douglas Costa Gontijoa , Maria Fernanda Alves do Nascimentoa, Geraldo Célio Brandãob & Alaíde Braga de Oliveiraa* a Departamento de Produtos Farmacêuticos, Universidade Federal ...
Tópico(s): Chemical synthesis and alkaloids
2019 - Taylor & Francis | Natural Product Research
Produção Nacional
Revisado por pares
Pilar Ester Luengas Caicedo, Fernão Castro Braga, Geraldo Célio Brandão, Alaı́de Braga de Oliveira,
Cecropia glaziovi Sneth. (syn. C. glaziovii, C. glazioui) (Cecropiaceae) is a South American medicinal plant whose antihypertensive activity is attributed to its flavonoid and proanthocyanidin contents. The seasonal and intraspecific variations of these two classes of compounds in C. glaziovi leaves were assayed by spectrophotometry in samples of young and mature leaves collected from native, cultivated and micropropagated trees in the dry and rainy periods of the year. The total flavonoid and proanthocyanidin ...
Tópico(s): Phytochemicals and Antioxidant Activities
2007 - De Gruyter | Zeitschrift für Naturforschung C
Produção Nacional
Revisado por pares
Geraldo Mendes dos Santos, Arnaldo Braga de OLIVEIRA,
A hidrelétrica de Balbina localiza-se no rio Uatumã, a 170 km de Manaus, pela BR/174. O enchimento do reservatório iniciou-se em outubro/87 e a usina começou a funcionar em fevereiro de 1989, com apenas uma das suas cinco turbinas. Apesar da redução da diversidade da ictiofauna e dos danos ambientais e sociais decorrentes do represamento, algumas espécies de peixes proliferaram no reservatório, resultando no incremento da atividade pesqueira, praticada basicamente sobre os estoques de tucunaré (Cichla ...
Tópico(s): Fish Biology and Ecology Studies
1999 - INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA | Acta Amazonica
Produção Nacional
Revisado por pares
Valdicley Vieira Vale, Thyago C Vilhena, Rafaela C. S. da Trindade, Márlia Regina C Ferreira, Sandro Percário, Luciana Ferreira Soares, Washington Luiz Assunção Pereira, Geraldo Célio Brandão, Alaı́de Braga de Oliveira, Maria Fâni Dolabela, Flávio Vasconcelos,
Plasmodium falciparum has become resistant to some of the available drugs. Several plant species are used for the treatment of malaria, such as Himatanthus articulatus in parts of Brazil. The present paper reports the phyto-chemistry, the anti-plasmodial and anti-malarial activity, as well as the toxicity of H. articulatus. Ethanol and dichloromethane extracts were obtained from the powder of stem barks of H. articulatus and later fractionated and analysed. The anti-plasmodial activity was assessed ...
Tópico(s): Trypanosoma species research and implications
2015 - BioMed Central | Malaria Journal
Produção Nacional
Revisado por pares
Ana Lúcia Silva Gomes, Josué Gomes Coelho Filho, Wallon Viana Silva, Maria Inês Braga de Oliveira, Geraldo Bernardino, Jesaías Ismael da Costa,
This study evaluates the impact of Neoechinorhynchus buttnerae on the productive and economic performance of "tambaqui" reared in ponds.Two fish farms were selected, one with infected fish (IF) and the other with non-infected fish (NIF).Biometry, age, initial weight and handling data were collected from each studied specimen.Our results show that IF presented lower weight, evident loss of body mass and body deformities, reflecting on a condition factor 300% smaller than NIF.Infection by acanthocephalans ...
Tópico(s): Fish Biology and Ecology Studies
2017 - Escuela de Ciencias del Mar, Facultad de Recursos Naturales, Pontificia Universidad Católica de Valparaíso | Latin American Journal of Aquatic Research
Produção Nacional
Revisado por pares
Rodrigo Alves de Oliveira, Cláudio G. Lima, Rosa Ms Mota, Alice Maria Costa Martins, Talita Rojas Sanches, Antônio Carlos Seguro, Lúcia Andrade, Geraldo Bezerra da Silva, Alexandre Braga Libório, Elizabeth De Francesco Daher,
Renal evaluation studies are rare in American Cutaneous Leishmaniasis (ACL). The aim of this study is to investigate whether specific treatment reverts ACL-associated renal dysfunction. A prospective study was conducted with 37 patients with ACL. Urinary concentrating and acidification ability was assessed before and after treatment with pentavalent antimonial. The patients mean age was 35.6 ± 12 years and 19 were male. Before treatment, urinary concentrating defect (U/Posm <2.8) was identified in 27 ...
Tópico(s): Research on Leishmaniasis Studies
2012 - BioMed Central | BMC Nephrology
Produção Nacional
Revisado por pares
Rodrigo Azevedo de Oliveira, Lucyo Flávio Bezerra Diniz, Leonardo O. Teotônio, Cláudio G. Lima, Rosa Maria Salani Mota, Alice Maria Costa Martins, Talita Rojas Sanches, Antônio Carlos Seguro, Lúcia Andrade, Geraldo Bezerra da Silva, Alexandre Braga Libório, Elizabeth De Francesco Daher,
Renal dysfunction seen in patients with American cutaneous leishmaniasis (ACL) has been attributed to the use of antimonials for treatment. To determine whether ACL itself causes tubular dysfunction, we measured renal function in 37 patients with ACL prior to their treatment and compared results to that in 10 healthy volunteers of similar mean age. None of the patients presented with glomerular dysfunction; however, 27 had a urinary concentrating defect. There was no statistical difference between ...
Tópico(s): Trypanosoma species research and implications
2011 - Elsevier BV | Kidney International
Produção Nacional
Revisado por pares
Geraldo Bezerra da Silva, Alexandre Braga Libório, Elizabeth De Francesco Daher,
Tópico(s): Erythrocyte Function and Pathophysiology
2011 - Springer Science+Business Media | Annals of Hematology
Produção Nacional
Revisado por pares
Ana Flávia Gomes da Cruz, Adriana Cotta Cardoso Reis, Jordano Augusto Carvalho Sousa, Luana Beatriz Araújo Vaz, Breno de Mello Silva, Cíntia Lopes de Brito Magalhães, Markus Kohlhoff, Alaı́de Braga de Oliveira, Geraldo Célio Brandão,
Plant extracts are complex mixtures that are difficult to characterize, and mass spectrometry is one of the main techniques currently used in dereplication processes.
Tópico(s): Psidium guajava Extracts and Applications
2022 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
Douglas Costa Gontijo, Pablo da Costa Gontijo, Geraldo Célio Brandão, Marisa Alves Nogueira Diaz, Alaı́de Braga de Oliveira, Luciano Gomes Fietto, João Paulo Viana Leite,
Ethnopharmacological relevance; Several plant species of Miconia genus are commonly used in Brazilian folk medicine as anti-inflammatory agents and for the treatment of infectious diseases. Infusions and extracts of Miconia species are also reported as analgesic, antimicrobial, antimalarial, antioxidant, anti-inflammatory, antinociceptive, antimutagenic, and antitumoral. Aim of the study; To determine the phytochemical composition of an aqueous extract of Miconia latecrenata leaves and to evaluate ...
Tópico(s): Pomegranate: compositions and health benefits
2019 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Douglas Costa Gontijo, Geraldo Célio Brandão, Pablo da Costa Gontijo, Alaı́de Braga de Oliveira, Marisa Alves Nogueira Diaz, Luciano Gomes Fietto, João Paulo Viana Leite,
Ocotea odorifera (Vell.) Rohwer is popularly used as food and flavoring. The aim of this study was to determine the chemical composition of the aqueous extract from O. odorifera leaves and evaluate the correlation of their phytochemical composition and biological activities. The antioxidant effect was determined by DPPH radical scavenging, β-carotene-linoleic acid and lipid peroxidation assays; the antibacterial activity was evaluated by the hole plate and MIC techniques and the antimutagenic activity ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2017 - Elsevier BV | Food Chemistry
Produção Nacional
Revisado por pares
Myrth Soares do Nascimento, Nayla di Paula Vieira Pina, Andressa Santa Brígida da Silva, Luis Fábio dos Santos Gomes, Flávio de Vasconcellos, Geraldo Célio Brandão, Maria Fernanda Alves do Nascimento, Alaı́de Braga de Oliveira, Wagner Luiz Ramos Barbosa,
Aspidosperma excelsum Benth. (Apocynaceae), a native tree in the Brazilian Amazonia, is traditionally used to treat various diseases, including malaria.To investigate the chemical constitution, antiplasmodial activity and cytotoxicity of samples obtained from A. excelsum trunk bark by different procedures aiming to evaluate their potential as an antimalarial phytomedicine.A hydroethanolic extract and alkaloid extracts were prepared and assayed for antiplasmodial activity and cytotoxicity against ...
Tópico(s): Alkaloids: synthesis and pharmacology
2018 - Elsevier BV | Journal of Ethnopharmacology
Produção Nacional
Revisado por pares
Ronan Batista, Geraldo Célio Brandão, Fernão Castro Braga, Alaı́de Braga de Oliveira,
Wedelia paludosa D.C. (Asteraceae) is an ornamental species occurring in many regions of Brazil. Aiming to find new cytotoxic compounds, the hydromethanol extract of W. paludosa (HME), as well as the dichloromethane (DF) and water (WF) fractions resulting from its partition, were submitted to the brine shrimp lethality bioassay (BSLB) in order to evaluate their cytotoxicity. Dichloromethane fraction (DF) was shown to be the most cytotoxic fraction (LC50 = 140.6 μg/mL), and its analysis by reversed phase ...
Tópico(s): Allelopathy and phytotoxic interactions
2009 - Springer Science+Business Media | Revista Brasileira de Farmacognosia
Produção Nacional
Edson Moreira Borges, Amanda Souza Setti, D. P. A. F. Braga, Murilo Vieira Geraldo, Rita de Cassia Sávio Figueira, Assumpto Iaconelli,
This study aims to find whether microRNAs (miRNAs) detected in the culture medium of embryos produced in vitro could be potential biomarkers of embryo implantation.Culture media samples from 36 embryos, derived from patients undergoing intracytoplasmic sperm injection (ICSI) in a private university-affiliated IVF center, were collected between January/2015 and November/2015. Samples were collected on day three and embryo transfers were performed on day five and all embryos reached the blastocyst stage. ...
Tópico(s): Circular RNAs in diseases
2016 - Brazilian Society of Assisted Reproduction | JBRA
Produção Nacional
Revisado por pares
Douglas Costa Gontijo, Geraldo Célio Brandão, Maria Fernanda Alves do Nascimento, Alaı́de Braga de Oliveira,
To assess the antiplasmodial activity of the ethanol extract of Xylopia sericea leaves, Annonaceae, often associated with antimalarial use and to perform a bioguided isolation of active compounds.Dereplication of ethanol extract by the UPLC-DAD-ESI-MS/MS technique allowed the identification of the major constituents, isolation and identification of alkaloids. The antiplasmodial and cytotoxic activity of the extract, fractions and isolated compounds was evaluated against the chloroquine-resistant ...
Tópico(s): Alkaloids: synthesis and pharmacology
2018 - Oxford University Press | Journal of Pharmacy and Pharmacology
Produção Nacional
Revisado por pares
Celina Maria Turchi Martelli, João Bosco Siqueira, Mírian Perpétua Palha Dias Parente, Ana Laura de Sene Amâncio Zara, Consuelo Silva de Oliveira, Cynthia Braga, Fabiano Geraldo Pimenta, Fanny Cortés, Juan Guillermo López, Luciana Bahia, Marcia Costa Ooteman Mendes, Michelle Quarti Machado da Rosa, Noêmia Teixeira de Siqueira Filha, Dagna Constenla, Wayner Vieira de Souza,
Background Dengue is an increasing public health concern in Brazil. There is a need for an updated evaluation of the economic impact of dengue within the country. We undertook this multicenter study to evaluate the economic burden of dengue in Brazil. Methods We estimated the economic burden of dengue in Brazil for the years 2009 to 2013 and for the epidemic season of August 2012- September 2013. We conducted a multicenter cohort study across four endemic regions: Midwest, Goiania; Southeast, Belo ...
Tópico(s): Global Maternal and Child Health
2015 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Valéria Fonseca Moscardini, Pablo da Costa Gontijo, Geraldo Andrade Carvalho, Rodrigo Lopes de Oliveira, Jader Braga Maia, Fernanda Fonseca e Silva,
The predatory bug Orius insidiosus is an important biological control agent of several insect pests, and is one of the most commonly used species in biological control programs worldwide. This study assessed the lethal and sublethal effects of insecticides on this species through life table, and classified the insecticides according to the definitions of toxicity given by the International Organization for Biological and Integrated Control of Noxious Animals and Plants (IOBC). A bioassay was carried ...
Tópico(s): Insect Resistance and Genetics
2013 - Elsevier BV | Chemosphere
Produção Nacional
Revisado por pares
Larissa Froede Brito, Douglas Costa Gontijo, Renata Celi Lopes Toledo, Rafael Mazioli Barcelos, Alaı́de Braga de Oliveira, Geraldo Célio Brandão, Lirlândia P. Sousa, Sônia Machado Rocha Ribeiro, João Paulo Viana Leite, Luciano Gomes Fietto, José Humberto de Queiróz,
This study aimed phytochemical characterization (UPLC-DAD-MS/MS) of ethanolic extract of the leaves from Mangifera indica (EMI) and Mangiferin (MAN), analysis of the cytotoxic (MTT) and anti-inflammatory potential (expression of TNF-α) of EMI and MAN in vitro. In addition, was evaluate the effect on the mRNA expression of genes (CB1, PPARγ, adiponectin, resistin and leptin) associated with adipogenesis in adipose tissue of rats fed a cafeteria diet. Thus, wistar rats were treated by gavage with EMI and ...
Tópico(s): Adipokines, Inflammation, and Metabolic Diseases
2019 - Elsevier BV | Journal of Functional Foods
Luiz Eduardo Imbelloni, Douglas M. P. Teixeira, Thatiany Monteiro Coelho, Danielly Gomes, Rafaela Lopes Braga, Geraldo Borges de Morais Filho, Alberto da Silva,
To evaluate the initial results after the implementation of perioperative protocol in patients over 60 years of age undergoing surgical treatment for femur fractures.We conducted a prospective study of patients older than 60 years who were hospitalized with femur fracture. They were operated under spinal anesthesia and analgesia by lumbar plexus blockade. Data evaluation was performed before arrival in the operating room during surgery, in the post-anesthesia recovery room and in the ward the next ...
Tópico(s): Hip and Femur Fractures
2014 - Brazilian College of Surgeons | Revista do Colégio Brasileiro de Cirurgiões
Produção Nacional
Revisado por pares
Samuel Novais, Cássio Alencar Nunes, Natália Britto dos Santos, Ana Rafaela D'Amico, Geraldo Wilson Fernandes, Maurício Quesada, Rodrigo Fagundes Braga, Ana Carolina de Oliveira Neves,
Animal pollinators contribute to human food production and security thereby ensuring an important component of human well-being. The recent decline of these agents in Europe and North America has aroused the concern of a potential global pollinator crisis. In order to prioritize efforts for pollinator conservation, we evaluated the extent to which food production depends on animal pollinators in Brazil-one of the world's agriculture leaders-by comparing cultivated area, produced volume and yield ...
Tópico(s): Insect and Pesticide Research
2016 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Juliana J. R. Pardauil, Fábio Alberto de Molfetta, Miguel Braga, Luiz K.C. de Souza, Geraldo Narciso da Rocha Filho, José Roberto Zamian, Carlos Emmerson Ferreira da Costa,
Tópico(s): Sensory Analysis and Statistical Methods
2016 - Springer Science+Business Media | Journal of Thermal Analysis and Calorimetry
Produção Nacional
Revisado por pares
Gdayllon Cavalcante Meneses, Alexandre Braga Libório, Elizabeth De Francesco Daher, Geraldo Bezerra da Silva, Marcus Felipe Bezerra da Costa, Maria Araci de Andrade Pontes, Alice Maria Costa Martins,
We aimed to evaluate urinary MCP-1 and oxidative stress through urinary malondialdehyde (MDA) in leprosy and correlate them with traditional, but less sensitive markers of renal disease. This is a cross-sectional study of 44 patients with diagnosis of leprosy and no previous treatment. Skin smear was assessed through a bacteriological index - from 0 to 6+. Glomerular filtration rate (GFR), protein excretion rate, microalbuminuria, urinary oxidative stress, malondialdehyde (MDA) and urinary MCP-1 were ...
Tópico(s): Clusterin in disease pathology
2014 - BioMed Central | BMC Infectious Diseases
Produção Nacional
Revisado por pares
Leandro Ribeiro Simoes, Glauber Meireles Maciel, Geraldo Célio Brandão, Erna Geessien Kroon, Rachel Oliveira Castilho, Alaı́de Braga de Oliveira,
To investigate the in vitro antiviral activity of Distictella elongata (Vahl) Urb. ethanol extracts from leaves (LEE), fruits (FEE), stems and their main components.The antiviral activity was evaluated against human herpesvirus type 1 (HSV-1), murine encephalomyocarditis virus (EMCV), vaccinia virus Western Reserve (VACV-WR) and dengue virus 2 (DENV-2) by the 3-(4, 5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) colorimetric assay. LEE presented anti-HSV-1 [EC(50) 142.8 ± 5.3 μg ml(-1); selectivity ...
Tópico(s): Natural product bioactivities and synthesis
2011 - Oxford University Press | Letters in Applied Microbiology
Produção Nacional
Revisado por pares
Paulo Lucas Cerqueira Coelho, Mona N. Oliveira, Alessandra B. da Silva, Bruno Penas Seara Pitanga, Víctor Diógenes Amaral da Silva, Giselle Pinto de Faria, Geraldo Pedral Sampaio, Maria de Fátima Dias Costa, Suzana Braga‐de‐Souza, Sílvia Lima Costa,
This study aimed to investigate the antitumor and immunomodulatory properties of the flavonoid apigenin (5,7,4'-trihydroxyflavone), which was extracted from Croton betulaster Mull, in glioma cell culture using the high-proliferative rat C6 glioma cell line as a model. Apigenin was found to have the ability to reduce the viability and proliferation of C6 cells in a time-dependent and dose-dependent manner, with an IC50 of 22.8 µmol/l, 40 times lower than that of temozolomide (1000 µmol/l), after 72 ...
Tópico(s): Flavonoids in Medical Research
2016 - Lippincott Williams & Wilkins | Anti-Cancer Drugs
Produção Nacional
Revisado por pares
Adriana Cotta Cardoso Reis, Hélia Maria Marques de Moura, Breno de Mello Silva, Alaı́de Braga de Oliveira, Geraldo Célio Brandão,
Abstract Cissus erosa (Vitaceae), popularly known in Brazil as Cipó-fogo, is a medicinal plant used in the treatment of warts and external ulcers. The present study aimed to evaluate the activity of stems and leaves ethanol extracts of C. erosa against the Dengue and Zika virus by the MTT colorimetric method and to carry on the phytochemical characterization of active extracts by high performance liquid chromatography coupled to mass spectrometry (UPLC-MS). Only the leaves ethanol extract showed anti- ...
Tópico(s): Traditional and Medicinal Uses of Annonaceae
2020 - Rio de Janeiro Botanical Garden Research Institute | Rodriguésia
Produção Nacional
Revisado por pares
Rafael Alves Guimarães, Gabriela Policena, Hellen da Silva Cintra de Paula, Charlise Fortunato Pedroso, Raquel Silva Pinheiro, Alexander Itria, Olavo de Oliveira Braga Neto, Adriana Melo Teixeira, Irisleia Aires Silva, Geraldo Andrade de Oliveira, Karla de Aleluia Batista,
The coronavirus disease (COVID-19) pandemic has impacted health services and healthcare systems worldwide. Studies have shown that hospital admissions for causes related to chronic non-communicable diseases (NCDs) have decreased significantly during peak pandemic periods. An analysis of the impact of the COVID-19 pandemic on hospital admissions for NCDs is essential to implement disability and mortality mitigation strategies for these groups. Therefore, this study aimed to analyze the impact of the ...
Tópico(s): Global Public Health Policies and Epidemiology
2022 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Geraldo Bezerra da Silva, Alexandre Braga Libório, Ana Patrícia Freitas Vieira, Amanda X. Couto, A. S. Lopes Filho, A.C. Figueiredo Filho, Aline L. Guedes, Jacqueline Holanda de Souza, Claudia Macedo Costa, Ricardo Costa, Elizabeth De Francesco Daher,
The objective of this study was to investigate renal function in a cohort of 98 patients with sickle cell disease (SCD) followed up at a tertiary hospital in Brazil. Clinical and laboratory characteristics at the time of the most recent medical examination were analyzed. Renal function was evaluated by the estimation of glomerular filtration rate (GFR) by the criteria of the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI). We compared patients with normal GFR to patients with decreased ...
Tópico(s): Blood groups and transfusion
2012 - Associação Brasileira de Divulgação Científica | Brazilian Journal of Medical and Biological Research
Produção Nacional
Douglas Costa Gontijo, Marisa Alves Nogueira Diaz, Geraldo Célio Brandão, Pablo da Costa Gontijo, Alaı́de Braga de Oliveira, Luciano Gomes Fietto, João Paulo Viana Leite,
Plant extracts exist as a complex matrix which serves as a source of numerous bioactive metabolites. The ultra performance liquid chromatography with diode-array detection-coupled electrospray ionization-mass spectrometry/mass spectrometry technique was used to characterize the aqueous extract from leaves of Alchornea glandulosa (EAG), a species popularly used to treat gastrointestinal problems as an antiulcer agent. Quantification of phenolic derivatives was determined using Folin–Ciocalteu and ...
Tópico(s): Phytochemistry and Biological Activities
2018 - Taylor & Francis | Journal of Toxicology and Environmental Health
Produção Nacional
Revisado por pares
Diego Pinto de Oliveira, Letícia de Almeida, Marcos José Marques, Roberta Ribeiro de Carvalho, Amanda Latércia Tranches Dias, Geraldo Alves da Silva, Rodrigo Maia de Pádua, Fernão Castro Braga, Marcelo Aparecido da Silva,
Leonotis nepetifolia (L.) Br. (Lamiaceae) is an African shrub popularly known as 'cordão-de-frade' in Brazil, traditionally used to treat infectious diseases, among other uses. This study aimed to investigate the phytochemical composition of hydroethanolic extracts from L. nepetifolia prepared from stems, leaves, roots and glomerulus, as well as their cytotoxicity, antileishmanial and antimicrobial activities. The chemical composition of the extracts was assessed by UPLC-ESI-MS/MS, whereas the antileishmanial ...
Tópico(s): Insect Pest Control Strategies
2019 - Taylor & Francis | Natural Product Research
Produção Nacional
Revisado por pares
Paulo Roberto Santos, Elizabeth De Francesco Daher, Geraldo Bezerra da Silva, Alexandre Braga Libório, Lígia Regina Franco Sansigolo Kerr,
Tópico(s): Muscle and Compartmental Disorders
2009 - Springer Science+Business Media | Quality of Life Research