Johann Steiner, Aye-Mu Myint, Kolja Schiltz, Sabine Westphal, Hans‐Gert Bernstein, Martin Walter, Matthias L. Schroeter, Markus Schwarz, Bernhard Bogerts,
Elevated blood levels of S100B in schizophrenia have so far been mainly attributed to glial pathology, as S100B is produced by astro- and oligodendroglial cells and is thought to act as a neurotrophic factor with effects on synaptogenesis, dopaminergic and glutamatergic neutrotransmission. However, adipocytes are another important source of S100B since the concentration of S100B in adipose tissue is as high as in nervous tissue. Insulin is downregulating S100B in adipocytes, astrocyte cultures and ...
Tópico(s): Traumatic Brain Injury and Neurovascular Disturbances
2010 - Hindawi Publishing Corporation | Cardiovascular Psychiatry and Neurology
Henryk Dreger, Kathi Westphal, Andrea Weller, Gert Baumann, Verena Stangl, Silke Meiners, K. Stangl,
We have shown previously that non-toxic inhibition of the ubiquitin–proteasome system upregulates antioxidative defence mechanisms and protects endothelial cells from oxidative stress. Here, we have addressed the question whether the induction of antioxidative enzymes contributes to cardioprotection by non-toxic proteasome inhibition. Treatment with 0.5 µmol/L MG132 for 48 h proved to be non-toxic and protected neonatal rat cardiac myocytes against H2O2-mediated oxidative stress in lactate dehydrogenase ...
Tópico(s): Redox biology and oxidative stress
2009 - Oxford University Press | Cardiovascular Research
Henryk Dreger, Kera Westphal, Nicola Wilck, Gert Baumann, Verena Stangl, Karl Stangl, Silke Meiners,
Increased levels of reactive oxygen species cause oxidative stress and severely damage lipids, proteins, and DNA. We have previously shown that partial proteasome inhibition induces an antioxidative gene pattern in endothelial cells. Here, we elucidate the mechanisms of proteasome inhibitor-mediated upregulation of antioxidative enzymes and cytoprotection. Non-toxic proteasome inhibition upregulated mRNA and protein expression of superoxide dismutase 1 (SOD1) and haem oxygenase 1 (HO1) in several ...
Tópico(s): Coenzyme Q10 studies and effects
2009 - Oxford University Press | Cardiovascular Research
Johann Steiner, Zoltán Sarnyai, Sabine Westphal, Tomasz Gos, Hans‐Gert Bernstein, Bernhard Bogerts, Gerburg Keilhoff,
Tópico(s): Stress Responses and Cortisol
2011 - Springer Science+Business Media | European Archives of Psychiatry and Clinical Neuroscience
Johann Steiner, Reinhilde Jacobs, Benjamin Panteli, Mareike Brauner, Kolja Schiltz, Sabine Bahn, Marlis Herberth, Sabine Westphal, Tomasz Gos, Martin Walter, Hans‐Gert Bernstein, Aye-Mu Myint, Bernhard Bogerts,
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
2010 - Springer Science+Business Media | European Archives of Psychiatry and Clinical Neuroscience
Julia Truthmann, Gert Mensink, Anja Bosy‐Westphal, Ulfert Hapke, Christa Scheidt‐Nave, Anja Schienkiewitz,
This study examined sex-specific differences in physical health-related quality of life (HRQoL) across subgroups of metabolic health and obesity. We specifically asked whether (1) obesity is related to lower HRQoL independent of metabolic health status and potential confounders, and (2) whether associations are similar in men and women.We used cross-sectional data from the German Health Interview and Examination Survey 2008-11. Physical HRQoL was measured using the Short Form-36 version 2 physical ...
Tópico(s): Physical Activity and Health
2017 - BioMed Central | Health and Quality of Life Outcomes
Produção Nacional
Revisado por pares
Johann Steiner, Brisa S. Fernandes, Paul C. Guest, Henrik Dobrowolny, Gabriela Meyer-Lotz, Sabine Westphal, Katrin Borucki, Kolja Schiltz, Zoltán Sarnyai, Hans‐Gert Bernstein,
Tópico(s): Tryptophan and brain disorders
2018 - Springer Science+Business Media | European Archives of Psychiatry and Clinical Neuroscience
Julia Truthmann, Gert Mensink, Anja Bosy‐Westphal, Christa Scheidt‐Nave, Anja Schienkiewitz,
Objective The study examined potential changes in the proportion of metabolic health according to body size categories over time and across strata of sex and age, varying definitions of metabolic health. Methods We analysed data from national health interview and examination surveys 1997–99 and 2008–11 for adults aged 18–79 years (GNHIES98: N = 6,565; DEGS1: 6,860). Metabolic health as defined by ATPIII criteria was examined across body mass index categories. The Plourde and Karelis criteria were applied ...
Tópico(s): Diet and metabolism studies
2016 - Public Library of Science | PLoS ONE
Autoradiographical tracing results in the cat indicate that the lateral pontine tegmental field projects mainly contralaterally to the marginal layer of the spinal trigeminal nucleus, to laminae I and II and the lateral part of laminae V and VI of the spinal cord and the Edinger-Westphal nucleus. It is pointed out that the projections from the lateral pontine tegmentum are very similar to the ones derived from the Edinger-Westphal nucleus and that these two areas are reciprocally connected. It is ...
Tópico(s): Anesthesia and Pain Management
1986 - Elsevier BV | Neuroscience Letters
Kera Westphal, Verena Stangl, Michael Fähling, Henryk Dreger, Andrea Weller, Gert Baumann, Karl Stangl, Silke Meiners,
Glutathione peroxidase-3 (GPx-3) is a key antioxidant enzyme in the plasma. GPx-3 was previously identified as the major antioxidative enzyme that was induced upon nontoxic proteasome inhibition in endothelial cells. Here, we investigated the determinants of the proteasome inhibitor-induced expression of GPx-3. Nontoxic proteasome inhibition massively upregulates GPx-3 RNA and protein in human umbilical cord vein cells within 24 h. Surprisingly, induction of GPx-3 was species-specific for human cells. ...
Tópico(s): Redox biology and oxidative stress
2009 - Elsevier BV | Free Radical Biology and Medicine
Gregory M. Enns, Robert D. Steiner, Neil R.M. Buist, Charles A. Cowan, Kathleen A. Leppig, Marjorie F. McCracken, Vibeke Westphal, Hudson H. Freeze, John F. O’Brien, Jaak Jaeken, Gert Matthijs, Sarina K. Behera, Louanne Hudgins,
To increase awareness of congenital disorders of glycosylation (CDG), we report the features of patients with a variety of clinical presentations ranging from mild hypotonia and strabismus to severe neurologic impairment.Nine North American patients with CDG type I and different ethnic origins were studied.All patients had transferrin isoelectric focusing studies with a type 1 sialotransferrin pattern. Molecular analysis showed the previously described R141H, V231M, and T237M PMM2 mutations in four ...
Tópico(s): RNA modifications and cancer
2002 - Elsevier BV | The Journal of Pediatrics
Tópico(s): Historical, Literary, and Cultural Studies
2017 - De Gruyter | Arbitrium
Antje Ludwig, Wolfram C. Poller, Kera Westphal, Susann Minkwitz, Gisela Lättig-Tünnemann, Susanne Metzkow, Karl Stangl, Gert Baumann, Matthias Taupitz, Susanne Wagner, Jörg Schnorr, Verena Stangl,
Tópico(s): Protease and Inhibitor Mechanisms
2013 - Springer Nature | Basic Research in Cardiology
Tobias Lühr, Aimo Winkelmann, Gert Nolze, Dominique Krull, C. Westphal,
In order to understand the physical and chemical properties of advanced materials, functional molecular adsorbates, and protein structures, a detailed knowledge of the atomic arrangement is essential. Up to now, if subsurface structures are under investigation, only indirect methods revealed reliable results of the atoms' spatial arrangement. An alternative and direct method is three-dimensional imaging by means of holography. Holography was in fact proposed for electron waves, because of the electrons' ...
Tópico(s): Advanced Materials Characterization Techniques
2016 - American Chemical Society | Nano Letters
Johann Steiner, Sabine Westphal, Matthias L. Schroeter, Kolja Schiltz, Wolfgang Jordan, Ulf Müller, Hans‐Gert Bernstein, Bernhard Bogerts, Reinhold E. Schmidt, Reinhilde Jacobs,
Several studies have provided evidence for increased S100B serum concentrations in schizophrenia. The pathophysiological significance of this finding is still uncertain because S100B is involved in many cellular mechanisms and is not astrocyte-specific as was previously assumed. S100B is also expressed by subsets of CD3+ CD8+ T cells and natural killer (NK) cells and may therefore be linked to the immune hypothesis of schizophrenia. We have quantified S100B+ CD3+ CD8+ T cells and NK cells by flow ...
Tópico(s): Stress Responses and Cortisol
2012 - Elsevier BV | Brain Behavior and Immunity
Produção Nacional
Revisado por pares
Johann Steiner, Daniel Martins‐de‐Souza, Kolja Schiltz, Zoltán Sarnyai, Sabine Westphal, Berend Isermann, Henrik Dobrowolny, Christoph W. Turck, Bernhard Bogerts, Hans‐Gert Bernstein, Tamas L. Horváth, Lorenz Schild, Gerburg Keilhoff,
Clozapine displays stronger systemic metabolic side effects than haloperidol and it has been hypothesized that therapeutic antipsychotic and adverse metabolic effects of these drugs are related. Considering that cerebral disconnectivity through oligodendrocyte dysfunction has been implicated in schizophrenia, it is important to determine the effect of these drugs on oligodendrocyte energy metabolism and myelin lipid production. Effects of clozapine and haloperidol on glucose and myelin lipid metabolism ...
Tópico(s): Tryptophan and brain disorders
2014 - Frontiers Media | Frontiers in Cellular Neuroscience
Julia Truthmann, Anja Schienkiewitz, Markus Busch, Gert Mensink, Yong Du, Anja Bosy‐Westphal, Hildtraud Knopf, Christa Scheidt‐Nave,
Monitoring of serum lipid concentrations at the population level is an important public health tool to describe progress in cardiovascular disease risk control and prevention. Using data from two nationally representative health surveys of adults 18–79 years, this study identified changes in mean serum total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglycerides (TG) in relation to changes in potential determinants of serum lipids between 1997–99 and 2008–11 in Germany. Sex- ...
Tópico(s): Nutritional Studies and Diet
2016 - BioMed Central | BMC Public Health
Johann Steiner, Hans‐Gert Bernstein, Kolja Schiltz, Ulf Müller, Sabine Westphal, Hemmo A. Drexhage, Bernhard Bogerts,
Impaired glucose metabolism and the development of metabolic syndrome contribute to a reduction in the average life expectancy of individuals with schizophrenia. It is unclear whether this association simply reflects an unhealthy lifestyle or whether weight gain and impaired glucose tolerance in patients with schizophrenia are directly attributable to the side effects of atypical antipsychotic medications or disease-inherent derangements. In addition, numerous previous studies have highlighted alterations ...
Tópico(s): Schizophrenia research and treatment
2012 - Elsevier BV | Progress in Neuro-Psychopharmacology and Biological Psychiatry
Johann Steiner, Kolja Schiltz, Martin Walter, Michael T. Wunderlich, Gerburg Keilhoff, Ralf Brisch, Hendrik Bielau, Hans‐Gert Bernstein, Bernhard Bogerts, Matthias L. Schroeter, Sabine Westphal,
Elevated blood levels of S100B in neuropsychiatric disorders have so far been mainly attributed to glial pathologies. However, increases or dysfunction of adipose tissue may be alternatively responsible. Our study assessed S100B serum levels in 60 adult subjects without a prior history of neuropsychiatric disorders. S100B concentrations were closely correlated with the body mass index (BMI, range 18–45 kg/m2) as well as levels of leptin and adipocyte-type fatty acid-binding protein (A-FABP/FABP4) ...
Tópico(s): Vitamin K Research Studies
2009 - Elsevier BV | Psychoneuroendocrinology
... 320 S.; erhältlich auch als Hörbuch, gelesen von Gert Westphal, Litraton Hörverlag. Google Scholar 3Heike Koschyk, Der Duft ...
Tópico(s): History and advancements in chemistry
2005 - Wiley | Angewandte Chemie
Branislav Líška, Ahmed A. Khattab, Lutz Herrmann, Mohamed Abdel‐Wahab, Ronja Westphal, Ralph Tölg, Volker Geist, Gert Richardt,
Though guidelines emphasize low-density lipoprotein cholesterol (LDL-C) lowering as an essential strategy for cardiovascular risk reduction, achieving target levels may be difficult. The authors conducted a prospective, controlled, open-label trial examining the effectiveness and safety of high-dose fluvastatin or a standard dosage of simvastatin plus ezetimibe, both with an intensive guideline-oriented cardiac rehabilitation program, in achieving the new ATP III LDL-C targets in patients with proven ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2008 - Springer Science+Business Media | Herz
Tom Rouwette, Tamás Kozicz, Nicola F.M. Olde Loohuis, Balázs Gaszner, Erno Vreugdenhil, Gert Jan Scheffer, Eric W. Roubos, Kris Vissers, Wim J.J.M. Scheenen,
The doublecortin-like kinase (DCLK) gene is crucially involved in neuronal plasticity and microtubule-guided retrograde transport of signaling molecules. We have explored the possibility that DCLK is involved in pain-induced signaling events in adult male Wistar rats. Our results show that both DCLK-short and DCLK-long splice variants are present in the cell body and proximal dendrites of neurons in stress-related nuclei, ie, the paraventricular nucleus of the hypothalamus (PVN) and the non-preganglionic ...
Tópico(s): Adipose Tissue and Metabolism
2010 - Elsevier BV | Journal of Pain
Gert Matthijs, Els Schollen, Cecilia Bjursell, Anna Erlandson, Hudson H. Freeze, Faiqa Imtiaz, Søren K. Kjærgaard, Tommy Martinsson, M. Schwartz, Nathalie Seta, Sandrine Vuillaumier‐Barrot, Vibeke Westphal, Bryan Winchester,
The PMM2 gene, which is defective in CDG-Ia, was cloned three years ago [Matthijs et al., 1997b]. Several publications list PMM2 mutations [Matthijs et al., 1997b, 1998; Kjaergaard et al., 1998, 1999; Bjursell et al., 1998, 2000; Imtiaz et al., 2000] and a few mutations have appeared in case reports or abstracts [Crosby et al., 1999; Kondo et al., 1999; Krasnewich et al., 1999; Mizugishi et al., 1999; Vuillaumier-Barrot et al., 1999, 2000b]. However, the number of molecularly characterized cases is ...
Tópico(s): Carbohydrate Chemistry and Synthesis
2000 - Wiley | Human Mutation
Johann Steiner, Hans‐Gert Bernstein, Kolja Schiltz, Thekla Haase, Gabriela Meyer-Lotz, Henrik Dobrowolny, Ulf Müller, Daniel Martins‐de‐Souza, Katrin Borucki, Matthias L. Schroeter, Berend Isermann, Bernhard Bogerts, Sabine Westphal,
Increased S100B serum levels have been considered as a marker of glial pathology, brain damage, and blood-brain-barrier impairment. However, S100B expression has also been detected outside the nervous system, suggesting that altered S100B serum levels may not exclusively reflect brain-specific pathologies. Notably, S100B secretion in adipocytes seems to be down-regulated by insulin, and up-regulated by stress and fasting. Therefore, we assumed that dynamic changes of S100B could be observed by challenging ...
Tópico(s): Vitamin K Research Studies
2013 - Elsevier BV | Psychoneuroendocrinology
... Journal of Vision 7.14.19: 1–14. Westphal, Jonathan. 1987. Colour. Oxford : Blackwell. Yablo, Stephen. 1995. “ ...
Tópico(s): Multisensory perception and integration
2010 - Wiley | Noûs
Tobias Lühr, Aimo Winkelmann, Gert Nolze, C. Westphal,
Tópico(s): Advanced Electron Microscopy Techniques and Applications
2013 - Wiley | Acta Crystallographica Section A Foundations of Crystallography
Tobias Luehr, Aimo Winkelmann, Gert Nolze, C. Westphal,
Tópico(s): Advanced X-ray Imaging Techniques
2015 - Cambridge University Press | Bulletin of the American Physical Society
Tom Rouwette, K. Klemann, Balázs Gaszner, Gert Jan Scheffer, Eric W. Roubos, Wim J.J.M. Scheenen, Kris Vissers, Tamás Kozicz,
... Ucn1 expression in the midbrain non-preganglionic Edinger–Westphal nucleus (npEW). Thirty minutes after APS, induced by ...
Tópico(s): Pharmacological Effects of Natural Compounds
2011 - Elsevier BV | Neuroscience
... VTA), the rostral raphe nuclei, the nucleus Edinger‐Westphal, the dorsal part of the substantia nigra, the ...
Tópico(s): Sleep and Wakefulness Research
1987 - Wiley | The Journal of Comparative Neurology
Jan C. den Heijer, Ward L. E. M. Bollen, J. P. H. Reulen, J. Gert van Dijk, C.G.S. Kramer, R. A. C. Roos, O. J. S. Buruma,
... may indicate involvement of the pretectal or Edinger-Westphal nuclei in HD. No further signs of autonomic ...
Tópico(s): Neurological disorders and treatments
1988 - American Medical Association | Archives of Neurology