Juliane Gertrude Bogner‐Strauß, Robert Zimmermann, Andelko Hrzenjak, Yong-Gang Zhou, Dagmar Kratky, Sanja Levak‐Frank, Gert M. Kostner, Rudolf Zechner, Saša Frank,
Endothelial cell-derived lipase (EDL) is a new member of the lipase gene family with high sequence homology with lipoprotein lipase (LPL). EDL is a phospholipase with very little triacylglycerol lipase activity. To investigate the effects of EDL on binding and uptake of high-density lipoprotein (HDL), as well as on the selective uptake of HDL-derived cholesterol esters (CEs), HepG2 cells were infected with adenovirus coding for EDL. For comparison, cells were also infected with LPL and with lacZ as ...
Tópico(s): Lipid metabolism and biosynthesis
2002 - Portland Press | Biochemical Journal
Robert Zimmermann, Juliane Gertrude Bogner‐Strauß, Guenter Haemmerle, Gabriele Schoiswohl, Ruth Birner‐Gruenberger, Monika Riederer, Achim Lass, Georg Neuberger, Frank Eisenhaber, Albin Hermetter, Rudolf Zechner,
Mobilization of fatty acids from triglyceride stores in adipose tissue requires lipolytic enzymes. Dysfunctional lipolysis affects energy homeostasis and may contribute to the pathogenesis of obesity and insulin resistance. Until now, hormone-sensitive lipase (HSL) was the only enzyme known to hydrolyze triglycerides in mammalian adipose tissue. Here, we report that a second enzyme, adipose triglyceride lipase (ATGL), catalyzes the initial step in triglyceride hydrolysis. It is interesting that ATGL ...
Tópico(s): Muscle metabolism and nutrition
2004 - American Association for the Advancement of Science | Science
Guenter Haemmerle, Robert Zimmermann, Juliane Gertrude Bogner‐Strauß, Dagmar Kratky, Monika Riederer, Gabriele Knipping, Rudolf Zechner,
Hormone-sensitive lipase (HSL) is believed to play an important role in the mobilization of fatty acids from triglycerides (TG), diglycerides, and cholesteryl esters in various tissues. Because HSL-mediated lipolysis of TG in adipose tissue (AT) directly feeds non-esterified fatty acids (NEFA) into the vascular system, the enzyme is expected to affect many metabolic processes including the metabolism of plasma lipids and lipoproteins. In the present study we examined these metabolic changes in induced ...
Tópico(s): Adipose Tissue and Metabolism
2002 - Elsevier BV | Journal of Biological Chemistry
Ruth Birner‐Gruenberger, Heidrun Susani‐Etzerodt, Markus Waldhuber, Gernot Riesenhuber, Hannes Schmidinger, Gerald N. Rechberger, Manfred Kollroser, Juliane Gertrude Bogner‐Strauß, Achim Lass, Robert Zimmermann, Guenter Haemmerle, Rudolf Zechner, Albin Hermetter,
Hydrolysis of triacylglycerols and cholesteryl esters is a key event in energy homeostasis of animals. However, many lipolytic activities still await their molecular identification. Here we report on a novel tool for concomitant analysis of lipases in complex proteomes. Fluorescent activity tags mimicking lipid substrates were used to label the proteome of mouse adipose tissue. Analysis by two-dimensional gel electrophoresis and LC-MS/MS led to the identification of all known intracellular lipases ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2005 - Elsevier BV | Molecular & Cellular Proteomics
Rudolf Zechner, Juliane Gertrude Bogner‐Strauß, Guenter Haemmerle, Achim Lass, Robert Zimmermann,
The lipolytic catabolism of stored fat in adipose tissue supplies tissues with fatty acids as metabolites and energy substrates during times of food deprivation. This review focuses on the function of recently discovered enzymes in adipose tissue lipolysis and fatty acid mobilization.The characterization of hormone-sensitive lipase-deficient mice provided compelling evidence that hormone-sensitive lipase is not uniquely responsible for the hydrolysis of triacylglycerols and diacylglycerols of stored ...
Tópico(s): Pancreatic function and diabetes
2005 - Lippincott Williams & Wilkins | Current Opinion in Lipidology
Carina Gröschel, André Sasse, Sebastian Monecke, Charlotte Röhrborn, Leslie Elsner, Michael Didié, Verena Reupke, Gertrude Bunt, Andrew H. Lichtman, Karl Toischer, Wolfram‐Hubertus Zimmermann, Gerd Hasenfuß, Ralf Dressel,
Heart failure due to pressure overload is frequently associated with inflammation. In addition to inflammatory responses of the innate immune system, autoimmune reactions of the adaptive immune system appear to be triggered in subgroups of patients with heart failure as demonstrated by the presence of autoantibodies against myocardial antigens. Moreover, T cell-deficient and T cell-depleted mice have been reported to be protected from heart failure induced by transverse aortic constriction (TAC) ...
Tópico(s): CAR-T cell therapy research
2018 - Frontiers Media | Frontiers in Immunology
Carina Gröschel, André Sasse, Charlotte Röhrborn, Sebastian Monecke, Michael Didié, Leslie Elsner, Vibeke Krüse, Gertrude Bunt, Andrew H. Lichtman, Karl Toischer, Wolfram‐Hubertus Zimmermann, Gerd Hasenfuß, Ralf Dressel,
Abstract We investigated whether CD4 + -T cells with specificity for an antigen in cardiomyocytes promote the progression from hypertrophy to heart failure in mice with increased pressure load due to transverse aortic constriction (TAC). OT-II mice expressing a transgenic T cell receptor (TCR) with specificity for ovalbumin (OVA) on CD4 + -T cells and cMy-mOVA mice expressing OVA on cardiomyocytes were crossed. The resulting cMy-mOVA-OT-II mice did not display signs of spontaneous autoimmunity despite the ...
Tópico(s): T-cell and B-cell Immunology
2017 - Nature Portfolio | Scientific Reports
Dagmar Kratky, Robert Zimmermann, Elke Wagner, Juliane Gertrude Bogner‐Strauß, Weijun Jin, Gerhard M. Kostner, Guenter Haemmerle, Daniel J. Rader, Rudolf Zechner,
Lipoprotein lipase (LPL) is thought to be the only enzyme responsible for the catabolism of triglycerides (TGs) associated with TG-rich lipoproteins in adipose tissue (AT). However, LPL deficiency in humans and induced mutant mice is not associated with decreased fat mass. We investigated whether endothelial lipase (EL), a recently discovered phospholipase, might represent an alternative mechanism for the uptake of phospholipid-derived fatty acids in murine lipoprotein-deficient AT. When LPL was expressed ...
Tópico(s): Lipid metabolism and biosynthesis
2005 - American Society for Clinical Investigation | Journal of Clinical Investigation
Dagmar Kratky, Robert Zimmermann, Elke Wagner, Juliane Gertrude Bogner‐Strauß, Weijun Jin, Gerhard M. Kostner, Guenter Haemmerle, Daniel J. Rader, Rudolf Zechner,
Lipoprotein lipase (LPL) is thought to be the only enzyme responsible for the catabolism of triglycerides (TGs) associated with TG-rich lipoproteins in adipose tissue (AT). However, LPL deficiency in humans and induced mutant mice is not associated with decreased fat mass. We investigated whether endothelial lipase (EL), a recently discovered phospholipase, might represent an alternative mechanism for the uptake of phospholipid-derived fatty acids in murine lipoprotein-deficient AT. When LPL was expressed ...
Tópico(s): Lipid metabolism and biosynthesis
2005 - American Society for Clinical Investigation | Journal of Clinical Investigation
Robert Zimmermann, Guenter Haemmerle, Elke Wagner, Juliane Gertrude Bogner‐Strauß, Dagmar Kratky, Rudolf Zechner,
It has been observed previously that hormone-sensitive lipase-deficient (HSL-ko) mice have reduced white adipose tissue (WAT) stores compared to control mice. These findings contradict the expectation that the decreased lipolytic activity in WAT of HSL-ko mice would cause accumulation of triglycerides (TGs) in that tissue. Here we demonstrate that the cellular TG synthesis in HSL-deficient WAT is markedly reduced due to downregulation of the enzymatic activities of glycerophosphate acyltransferase, ...
Tópico(s): Fatty Acid Research and Health
2003 - Elsevier BV | Journal of Lipid Research
Christian Pohl, Stephan Rist, Anne Zimmermann, Patricia Fry, Ghana S. Gurung, Flurina Schneider, Chinwe Ifejika Speranza, Boniface Kiteme, Sébastien Boillat, Elvira Serrano, Gertrude Hirsch Hadorn, Urs Wiesmann,
... Academic Google Scholar ... Show more Gertrude Hirsch Hadorn, Gertrude Hirsch Hadorn D-UWIS; Email: hirsch@env.ethz.ch Search for other works by this author on: Oxford Academic Google Scholar Urs Wiesmann Urs Wiesmann Centre for Development and Environment, University of Bern, Hallerstrasse 10, 3008 Bern, Switzerland; and also work for the NCCR North-South programme; Emails: Stephan.Rist@cde.unibe.ch; Anne.Zimmermann@cde.unibe.ch; flurina.schneider@fibl.org; sboillat@ ...
Tópico(s): Innovative Approaches in Technology and Social Development
2010 - Oxford University Press | Science and Public Policy
Achim Lass, Robert Zimmermann, Guenter Haemmerle, Monika Riederer, Gabriele Schoiswohl, Martina Schweiger, Petra C. Kienesberger, Juliane Gertrude Bogner‐Strauß, Gregor Gorkiewicz, Rudolf Zechner,
SummaryAdipose triglyceride lipase (ATGL) was recently identified as an important triacylglycerol (TG) hydrolase promoting the catabolism of stored fat in adipose and nonadipose tissues. We now demonstrate that efficient ATGL enzyme activity requires activation by CGI-58. Mutations in the human CGI-58 gene are associated with Chanarin-Dorfman Syndrome (CDS), a rare genetic disease where TG accumulates excessively in multiple tissues. CGI-58 interacts with ATGL, stimulating its TG hydrolase activity ...
Tópico(s): Pancreatic function and diabetes
2006 - Cell Press | Cell Metabolism
Amelia Fiske, Isabella M. Radhuber, Consuelo Fernández Salvador, Emília Rodrigues Araújo, Marie Jasser, Gertrude Saxinger, Bettina Zimmermann, Barbara Prainsack,
The COVID-19 pandemic sparked radical changes in the way life was lived around the globe. With the rapid reduction in human mobility, short-term environmental improvements were seen across the world. Work and social routines were altered, and political action to reduce case numbers seemed to open a window of opportunity for socio-environmental change in a post-pandemic world. Inspired by conversations around the “COVID-19 Anthropause,” this paper probes the lived experiences and reflections that ...
Tópico(s): Geographies of human-animal interactions
2024 - SAGE Publishing | Environment and Planning E Nature and Space
Mark Zimmermann, Gertrude Steins, Elizabeth LeCompte, John Collins, Steve Bodow, Moisés Kaufman, Mark Ravenhill, Gemma Bodinetz, Max Stafford-Clark,
1998 - The MIT Press | PAJ A Journal of Performance and Art
... Eckart Conze, Norbert Frei, Peter Hayes, and Moshe Zimmermann, Das Amt und die Vergangenheit. Deutsche Diplomaten im Dritten Reich und in der Bundesrepublik (München, 2010). 53. Rudolf Agstner, Gertrude Enderle-Burcel, and Michaela Follner, Österreichs Spitzendiplomaten zwischen ...
Tópico(s): Political Systems and Governance
2011 - Taylor & Francis | Diplomacy and Statecraft
Bettina Zimmermann, Katharina T. Paul, Emília Rodrigues Araújo, Alena Buyx, Sebastian Ferstl, Amelia Fiske, David Kraus, Luca Marelli, Stuart McLennan, Vittoria Porta, Barbara Prainsack, Isabella M. Radhuber, Gertrude Saxinger,
The uptake ofCOVID-19 vaccines has varied considerably across European countries. This study investigates people's decision-making process regarding vaccination by analyzing qualitative interviews (n = 214) with residents from five European countries: Austria, Germany, Italy, Portugal, and Switzerland. We identify three factors that shape vaccination decision-making: individual experiences and pre-existing attitudes towards vaccination, social environment, and socio-political context. Based on this ...
Tópico(s): Psychology of Moral and Emotional Judgment
2023 - Elsevier BV | Vaccine
Anthony Jenkins, Manuela Gieri, Juliana Spahr, Heiner Zimmermann, Barbara Godard, Laura Morrow,
... Bowers, "They Watch Me as They Watch This": Gertrude Stein's Melodrama, reviewed by Juliana Spahr Robert Wilcher, Understanding Arnold Wesker, reviewed by Heiner Zimmermann Annie Brisset, Sociocritique de la traduction: Theatre et ...
Tópico(s): Shakespeare, Adaptation, and Literary Criticism
1993 - University of Toronto Press | Modern Drama
Bettina Zimmermann, Hendrik Wagenaar, Katharina Kieslich, Barbara Prainsack, Gert Meyers, Alena Buyx, Seliem El-Sayed, Amelia Fiske, Ilaria Galasso, Susi Geiger, Nora Hangel, Ruth Horn, Stephanie Johnson, Janneke Kuiper, Federica Lucivero, Stuart McLennan, Katharina T. Paul, Mirjam Pot, Isabella M. Radhuber, Gabrielle Samuel, Tamar Sharon, Lotje Siffels, Ine Van Hoyweghen, Sula Awad, Théo Bourgeron, Johanna Eichinger, Marie Gaille, Christian Haddad, Sarah Hayes, Andrew Hoffman, Marie Jasser, Joke Kenens, Marjolein Lanzing, Sébastien Libert, Elisa Lievevrouw, Luca Marelli, Fernandos Ongolly, Amicia Phillips, Clémence Pinel, Katharina Riesinger, Stephen Roberts, Gertrude Saxinger, Lukas Schlögl, Franziska Schönweitz, Anna Sierawska, Wanda Spahl, Emma Stendahl, Siemen Vanstreels, Simeon Vidolov, Elias Weiss,
The sudden and dramatic advent of the COVID-19 pandemic led to urgent demands for timely, relevant, yet rigorous research. This paper discusses the origin, design, and execution of the SolPan research commons, a large-scale, international, comparative, qualitative research project that sought to respond to the need for knowledge among researchers and policymakers in times of crisis. The form of organization as a research commons is characterized by an underlying solidaristic attitude of its members ...
Tópico(s): Global Security and Public Health
2022 - Elsevier BV | SSM - Qualitative Research in Health
... wrote the “Albumblatt,” Ankunft bei den schwarzen Schwänen.Gertrude Atherton, Adventures of a Novelist (New York, 1932), ... of superiority (Adventures of a Novelist, p. 419).Gertrude Atherton, Black Oxen (New York, 1923), p. 321. ...
Tópico(s): German History and Society
1963 - Routledge | The Germanic Review Literature Culture Theory
... LATER MODERN: DARWIN AND THE DARWINIAN REVOLUTION. By Gertrude Himmelfarb LATER MODERN: DARWIN AND THE GENERAL READER. ... By A. P. Thornton LATER MODERN: Professor Ludwig Zimmermann's DEUTSCHE AUSSENPOLITIK IN DER ÄRA DER WEIMARER ...
1959 - Wiley | History
House/Lights, adapted from Gertrude Stein's Dr. Faustus Lights the Lights, directed by Elizabeth LeCompte, The Wooster Group at The Performing Garage, New York; ...
Tópico(s): Shakespeare, Adaptation, and Literary Criticism
1998 - The MIT Press | PAJ A Journal of Performance and Art