Francesco Ciccia, Giuliana Guggino, A. Rizzo, Stefano Bombardieri, Stefania Raimondo, Francesco Carubbi, Alessandra Cannizzaro, Guido Sireci, Francesco Dieli, Giuseppina Campisi, Roberto Giacomelli, Paola Cipriani, Giacomo De Leo, Riccardo Alessandro, G Triolo,
Summary The aim of this study was to elucidate more clearly the role of interleukin (IL)-18 in modulating the IL-22 pathway in primary Sjögren's syndrome (pSS) patients and in pSS-associated lymphomas. Minor salivary glands (MSGs) from patients with pSS and non-specific chronic sialoadenitis (nSCS), parotid glands biopsies from non-Hodgkin lymphomas (NHL) developed in pSS patients, were evaluated for IL-18, IL-22, IL-22 receptor 1 (IL-22R1), IL-22 binding protein (IL-22BP) and signal transducer and activator ...
Tópico(s): Inflammasome and immune disorders
2015 - Oxford University Press | Clinical & Experimental Immunology
Francesco Ursini, Piero Ruscitti, Giacomo Caio, Roberto Manfredini, Roberto Giacomelli, Roberto De Giorgio,
Rheumatoid arthritis (RA) is burdened by a significant increase in cardiovascular disease (CVD) risk. Amongst CVD risk factors, endothelial dysfunction and arterial stiffness represent powerful predictors of atherosclerosis and cardiovascular events in the general population and in RA patients.A systematic review of the literature was performed to identify the available data on the effect of non-TNF-targeted biologics licensed for the treatment of RA on endothelial function, arterial stiffness or ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2019 - Elsevier BV | Autoimmunity Reviews
Luca Giacomelli, Giacomo Derchi, Andrea Frustaci, Bruno Orlando, Ugo Covani, Antonio Barone, Daniele De Santis, Francesco Chiappelli,
Polishing may increase the surface roughness of composites, with a possible effect on bacterial growth and material properties. This preliminary in vitro study evaluates the effect of three different polishing systems (PoGo polishers, Enhance, Venus Supra) on six direct resin composites (Gradia Direct, Venus, Venus Diamond, Enamel Plus HFO, Tetric Evoceram, Filtek Supreme XT).For each composite, 12 square specimens were prepared: 9 specimens were polished, three for each different method, while three ...
Tópico(s): Orthodontics and Dentofacial Orthopedics
2010 - Bentham Science Publishers | The Open Dentistry Journal
Alessio Metere, Tiziano De Giacomo, Massimo Vergine, Marco Biffoni, Luciano Giacomelli,
The mediastinal ectopic thyroid is very rare, accounting for less than 1% of all cases of ectopic thyroid tissue. The differential diagnoses with other diseases such as lymphomas, thymic tumors and dermoid cysts is mandatory, in fact each one, needs different management and treatment. Here, we discuss a rare case of mediastinal ectopic thyroid presenting with a paratracheal mass laying on the right bronchus without symptoms. A 63-year-old male presented with an abnormal well-defined mass along the ...
Tópico(s): Tracheal and airway disorders
2018 - BioMed Central | BMC Surgery
Gino Marioni, Giancarlo Ottaviano, Andrea Lovato, Leonardo Franz, Luigia Bandolin, Giacomo Contro, Luciano Giacomelli, Lara Alessandrini, Roberto Stramare, Cosimo de Filippis, Stella Blandamura,
The main aim of this study was to conduct a preliminary investigation into the possible relationship between mTOR and the nuclear tumor suppressor maspin in laryngeal carcinoma (LSCC).mTOR expression and maspin pattern were ascertained, also with the aid of image analysis in 79 consecutive LSCCs.Considering the whole series, univariate statistical analysis identified significant differences in the distributions by lymph node status (N0 vs N+) between two subgroups of patients with and without loco- ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2019 - Elsevier BV | American Journal of Otolaryngology
Serena Colafrancesco, Roberta Priori, Guido Valesini, Lorenza Maria Argolini, Elena Baldissera, Elena Bartoloni, Daniele Cammelli, G. Canestrari, Luca Cantarini, Elena Cavallaro, Giulio Cavalli, Lucia Cerrito, Paola Cipriani, Lorenzo Dagna, G. De Marchi, Salvatore De Vita, Giacomo Emmi, Gianfranco Ferraccioli, Micol Frassi, Mauro Galeazzi, Roberto Gerli, Roberto Giacomelli, Elisa Gremese, Florenzo Iannone, Giovanni Lapadula, Giuseppe Lopalco, Raffaele Manna, Alessandro Mathieu, Carlomaurizio Montecucco, Marta Mosca, Ilaria Piazza, Matteo Piga, Irene Pontikaki, Micol Romano, Silvia Rossi, Maurizio Rossini, Piero Ruscitti, Elena Silvestri, Chiara Stagnaro, Rosaria Talarico, Anǵela Tincani, Ombretta Viapiana, Gianfranco Vitiello, F Fabris, Sara Bindoli, Leonardo Punzi, Paola Galozzi, Paolo Sfriso,
Background: Interleukin (IL)-1 plays a crucial role in the pathogenesis of Adult onset Still's disease (AOSD). Objectives: To evaluate the efficacy and safety of anakinra (ANA) and canakinumab (CAN) in a large group of AOSD patients. Methods: Data on clinical, serological features, and concomitant treatments were retrospectively collected at baseline and after 3, 6, and 12 months from AOSD patients (Yamaguchi criteria) referred by 18 Italian centers. Pouchot's score was used to evaluate disease severity. ...
Tópico(s): Immune Cell Function and Interaction
2017 - Frontiers Media | Frontiers in Pharmacology
Lucia Lisi, Jacopo Ciaffi, Antonella Bruni, Luana Mancarella, Veronica Brusi, Pasquale Gramegna, Claudio Ripamonti, Elisabetta Quaranta, Elena Borlandelli, Gaetano Gallo, Eugenio Garofalo, Agostino Chiaravalloti, Pasquale Viola, Piero Ruscitti, Giacomo Caio, Martina D’Onghia, Andrea D’Amuri, Antonio Cimellaro, Giancarlo Facchini, Micaela La Regina, Luca Spinardi, Roberto De Giorgio, Roberto Giacomelli, Maria Paola Landini, Domenico Berardi, Riccardo Melicòni, Francesco Ursini,
Background: Resilience is defined as the capacity to cope successfully with change or adversity. The aims of our study were to investigate levels of resilience in Italian healthcare professionals (HCPs) during the Coronavirus disease 2019 (COVID-19) pandemic and to identify potential predictors of resilience. Methods: We performed a web-based survey of HCPs (n = 1009) working in Italian hospitals during the COVID-19 pandemic. The survey contained a 14-item resilience scale (RS14) and questionnaires to ...
Tópico(s): Healthcare professionals’ stress and burnout
2020 - Multidisciplinary Digital Publishing Institute | Behavioral Sciences
François-Xavier Lescure, Hitoshi Honda, Robert Fowler, Jennifer Sloane Lazar, Genming Shi, Peter K. Wung, Naimish Patel, Owen Hagino, Ignacio J. Bazzalo, Marcelo Martín Casas, Sebastián A. Núñez, Yael Pere, Carlos M. Ibarrola, Marco A. Solis Aramayo, María Celia Cuesta, Andrea E. Duarte, Pablo Fernández, Maria A. Iannantuono, Erica A. Miyazaki, Javier P. Silvio, Darío Scublinsky, Alessandra Martins Bales, Daniela Catarino, Elie Fiss, Sara Mohrbacher, Victor Augusto Hamamoto Sato, Antonio Baylao, Adilson W. Cavalcante, Francini Guerra Correa, Celso A. de Andrade, Juvencio Furtado, Nelson Ribeiro Filho, Valéria Telles, Leopoldo Tosi Trevelin, Ricardo Vipich, Rodrigo Boldo, Paula Borges, Suzana M. Lobo, Graziela Denardin Luckemeyer, Luana Machado, Maysa B. Alves, Ana Caroline Coutinho Iglessias, Marianna M. Lago, Daniel Wagner de Castro Lima Santos, Hugo Chapdelaine, Emilia Liana Falcone, Rahima Jamal, Me‐Linh Luong, Madéleine Durand, Stéphane Doucet, François Martin Carrier, Bryan Coburn, Lorenzo Del Sorbo, Sharon Walmsley, Sara Belga, Luke Y. C. Chen, Allison Mah, Theodore S. Steiner, Alissa Wright, J Hájek, Neill K. J. Adhikari, Robert Fowler, Nick Daneman, Kosar Khwaja, Jason Shahin, Carolina González, Rafael Silva, Marcelo Lindh, Gabriel Maluenda, Patricia Fernández, Maite Oyonarte, Martín Lasso, Alexandre Boyer, D. Bronnimann, Hoang-Nam Bui, Charles Cazanave, H. Chaussade, Arnaud Desclaux, M. Ducours, Alexandre Duvignaud, Denis Malvy, Lisa J. Martin, D. Neau, Duc Thanh Nguyen, Thierry Pistone, Gaetane Soubrane-Wirth, Julie Leitao, Clotilde Allavena, Charlotte Biron, Sabelline Bouchez, Benjamin Gaborit, Antoine Grégoire, Paul Le Turnier, Anne-Sophie Lecompte, R. Lecomte, M. Lefèbvre, F. Raffi, D. Boutoille, P Morineau, Romain Guéry, Emmanuel Chatelus, Nathalie Dumoussaud, Renaud Felten, Florina Luca, B. Goichot, Francis Schneider, Marie‐Caroline Taquet, Matthieu Groh, Mathilde Roumier, Mathilde Neuville, Antoine Bachelard, Valentina Isernia, F-Xavier Lescure, Bao-Chau Phung, A. Rachline, Aurélie Sautereau, D. Vallois, Yves Bleher, Delphine Boucher, Clémentine Coudon, J.-L. Esnault, Thomas Guimard, Sophie Leautez-Nainville, Dominique Merrien, Marine Morrier, Pauline Motte-Vincent, R. Gabeff, Hélène Leclerc, Céline Cozic, Romain Decours, Ronan Février, Gwenhaël Colin, Sophie Abgrall, Dorothée Vignes, R. Sterpu, Mira Kuellmar, Melanie Meersch, Raphael Weiß, Alexander Zarbock, Christiane Antony, Marc Moritz Berger, Thorsten Brenner, Christian Taube, Frank Herbstreit, Sebastian Dolff, Margarethe Konik, Karsten Schmidt, Markus Zettler, Oliver Witzke, Boris Boell, Jorge Garcia Borrega, Philipp Koehler, Thomas Zander, Fabian Dusse, Othman Al‐Sawaf, Philipp Köhler, Dennis A. Eichenauer, Matthias Kochanek, Alexander Shimabukuro‐Vornhagen, Sibylle C. Mellinghoff, Annika Y. Claßen, Jan‐Michel Heger, Charlotte Meyer‐Schwickerath, P. Liedgens, Katrin Heindel, Ana Belkin, Asaf Biber, Mayan Gilboa, Itzchak Levy, Vladislav Litachevsky, Galia Rahav, Anat Finesod Wiedner, Tal Zilberman‐Daniels, Yonatan Oster, Jacob Strahilevitz, Sigal Sviri, Elena Baldissera, Corrado Campochiaro, Giulio Giovanni Cavalli, Lorenzo Dagna, Giacomo De Luca, Emanuel Della‐Torre, Alessandro Tomelleri, Davide Bernasconi De Luca, Amedeo Capetti, Massimo Coen, Maria Vittoria Cossu, Massimo Galli, Andrea Giacomelli, G. Gubertini, Stefano Rusconi, Giulia Burastero, Margherita Digaetano, Giovanni Guaraldi, Marianna Meschiari, Cristina Mussini, Cinzia Puzzolante, Sara Volpi, Marina Aiello, Alarico Ariani, Alfredo Chetta, Annalisa Frizzelli, Andrea Ticinesi, Domenico Tuttolomondo, Stefano Aliberti, Francesco Blasi, Marta Francesca Di Pasquale, Sofia Misuraca, Tommaso Pilocane, Edoardo Simonetta, Alessio M. Aghelmo, Claudio Angelini, Enrico Brunetta, Giorgio Walter Canonica, Michele Ciccarelli, Sara Dal Farra, Maria De Santis, Sebastian Ferri, Marco Folci, Giacomo Maria Guidelli, Enrico Heffler, Ferdinando Loiacono, Giacomo Malipiero, Giovanni Paoletti, Rosa Pedale, Francesca Puggioni, Francesca Racca, Aurora Zumbo, Morihiko Satou, Hitoshi Honda, Tatyana Lisun, Д. Н. Проценко, Nikolay Rubtsov, Irina P. Beloglazova, Daria Fomina, Mariana A. Lysenko, Sofia Serdotetskova, Vitali Firstov, И. Г. Гордеев, Ilia Kokorin, Ksenia Komissarova, Н П Лапочкина, Е. Е. Лучинкина, Valentin Malimon, S. S. Mamedguseyinova, Ksenia Polubatonova, Natalia A. Suvorova, José Ramón Arribas, Alberto M. Borobia Perez, Fernando Calle, Juan Carlos Figueira, Rocío Montejano, Marta Mora-Rillo, Concepcion Prados Sanchez, Javier Queiruga Parada, Francisco Arnalich, Maria Guerro Barrientos, Alejandro Bendala Estrada, A. Marcos, María Eugenia García Leoni, Rita García‐Martínez, Ana María Moreno Collado, Patricia Muñoz García, Ana Torres do Rego, María Victoria Villalba García, Almudena Burrillo, Maricela Valerio Minero, Paloma Gijon Vidaurreta, Sonsoles Infante Herrero, Elena Velilla, Marina Machado, María Olmedo, Blanca Pinilla, Benito Almirante, Esperanza Cañas‐Ruano, S Medina, Alejandro Cortés Herrera, Vicenç Falcó Ferrer, Ricard Ferrer, X. Nuvials Casals, Esteban Ribera, Paula Suanzes Diez, Pedro Rebollo Castro, Felipe García, Álex Soriano, Aina Oliver Caldes, Ana González-Cordón, Celia Cardozo, Lorena De la Mora Cañizo, Romina Pena López, Sandra Chamorro, Clara Crespillo‐Andújar, Rosa Escudero Sanchez, Jesús Fortün, Begoña Monge‐Maíllo, Santiago Moreno,
Elevated proinflammatory cytokines are associated with greater COVID-19 severity. We aimed to assess safety and efficacy of sarilumab, an interleukin-6 receptor inhibitor, in patients with severe (requiring supplemental oxygen by nasal cannula or face mask) or critical (requiring greater supplemental oxygen, mechanical ventilation, or extracorporeal support) COVID-19.We did a 60-day, randomised, double-blind, placebo-controlled, multinational phase 3 trial at 45 hospitals in Argentina, Brazil, Canada, ...
Elsevier BV
Mattia Di Segni, Valeria De Soccio, Vito Cantisani, Giacomo Bonito, Antonello Rubini, Gabriele Di Segni, Sveva Lamorte, Valentina Magri, Corrado De Vito, Giuseppe Migliara, Tommaso Vincenzo Bartolotta, Alessio Metere, Luciano Giacomelli, Carlo de Felice, F Dambrosio,
To assess the diagnostic performance and the potential as a teaching tool of S-detect in the assessment of focal breast lesions. 61 patients (age 21–84 years) with benign breast lesions in follow-up or candidate to pathological sampling or with suspicious lesions candidate to biopsy were enrolled. The study was based on a prospective and on a retrospective phase. In the prospective phase, after completion of baseline US by an experienced breast radiologist and S-detect assessment, 5 operators with ...
Tópico(s): Radiomics and Machine Learning in Medical Imaging
2018 - Springer Science+Business Media | Journal of Ultrasound
Giacomo Cafaro, Carlo Perricone, Francesco Carubbi, Chiara Baldini, Luca Quartuccio, Roberta Priori, Onorina Berardicurti, Francesco Ferro, Saviana Gandolfo, Angelica Gattamelata, Roberto Giacomelli, Salvatore De Vita, Roberto Gerli, Elena Bartoloni,
Purpose The prevalence of peripheral nervous system (PNS) involvement in primary Sjögren’s syndrome (pSS) has been reported to range from 2% to over 50%. Bias in study designs, including low number of patients and unclearly defined rheumatological and neurological diagnosis could explain such variability. Consequently, the exact depiction of PNS involvement in pSS is still lacking. This study aimed at analyzing the prevalence and the clinical and laboratory factors associated with PNS involvement ...
Tópico(s): Dermatology and Skin Diseases
2021 - Frontiers Media | Frontiers in Immunology
Produção Nacional
Revisado por pares
Carla Gaggiano, Alessandra Bianco, Jurgen Sota, Stefano Gentileschi, Piero Ruscitti, Roberto Giacomelli, Matteo Piga, Francesca Crisafulli, Sara Monti, Giacomo Emmi, Amato de Paulis, Antonio Vitale, Maria Tarsia, Valeria Caggiano, Rossana Nuzzolese, Veronica Parretti, Claudia Fabiani, Giuseppe Lopalco, Armin Maier, Marco Cattalini, Donato Rigante, Marcello Govoni, Francesca Li Gobbi, Serena Guiducci, Paola Parronchi, Achille Marino, Francesco Ciccia, Maria Cristina Maggio, Emma Aragona, Elena Bartoloni, Annamaria Iagnocco, Ombretta Viapiana, Gian Domenico Sebastiani, Silvana Guerriero, Antonella Insalaco, Emanuela Del Giudice, Giovanni Conti, Patrizia Barone, Alma Nunzia Olivieri, Antonio Brucato, Francesco Carubbi, Paola Triggianese, Angela Mauro, Gian Marco Tosi, Alex Fonollosa, Henrique Ayres Mayrink Giardini, Gaafar Ragab, Samar Tharwat, José Hernández‐Rodríguez, Petros P. Sfikakis, Katerina Laskari, Αναστάσιος Καραμανάκος, Gerard Espinosa, Farhad Shahram, Haner Direşkeneli, Andrea Hinojosa‐Azaola, Daniela Opriş-Belinski, Ibrahim Almaghlouth, Gülen Hatemi, Mehmet Akif Eksin, Fatoş Önen, Ewa Więsik–Szewczyk, Nurullah Akkoç, Abdurrahman Tufan, Ali Şahin, Şükran Erten, Seza Özen, Ezgi Deniz Batu, Bruno Frediani, Alberto Balistreri, Luca Cantarini,
This paper describes the creation and preliminary results of a patient-driven registry for the collection of patient-reported outcomes (PROs) and patient-reported experiences (PREs) in Behçet's disease (BD).The project was coordinated by the University of Siena and the Italian patient advocacy organization SIMBA (Associazione Italiana Sindrome e Malattia di Behçet), in the context of the AIDA (AutoInflammatory Diseases Alliance) Network programme. Quality of life, fatigue, socioeconomic impact of the ...
Tópico(s): Vasculitis and related conditions
2023 - Frontiers Media | Frontiers in Medicine
Francesco Ursini, Piero Ruscitti, Vincenzo Raimondo, Rossella De Angelis, Fabio Cacciapaglia, Erika Pigatto, Domenico Olivo, Ilenia Di Cola, Felice Galluccio, Francesca Francioso, Rosario Foti, Antonio Tavoni, Salvatore D’Angelo, Corrado Campochiaro, Francesca Motta, Maria De Santis, Silvia Bilia, Caterina Bruno, Giacomo De Luca, Marcella Visentini, Jacopo Ciaffi, Luana Mancarella, Veronica Brusi, Martina D’Onghia, Giovanna Cuomo, Enrico Fusaro, Lorenzo Dagna, Serena Guiducci, Riccardo Melicòni, Florenzo Iannone, Annamaria Iagnocco, Roberto Giacomelli, Clodoveo Ferri,
Abstract Background In the last decade, integrative studies of microbiome and metabolome have experienced exponential growth in understanding their impact on human health and diseases. However, analyzing the resulting multi-omics data and their correlations remains a significant challenge in current studies due to the lack of a comprehensive computational tool to facilitate data integration and interpretation. In this study, we have developed a microbiome and metabolome integrative analysis pipeline (M 2 ...
Tópico(s): COVID-19 Clinical Research Studies
2021 - BMJ | Annals of the Rheumatic Diseases
Francesco Ursini, Piero Ruscitti, Olga Addimanda, Rosario Foti, Vincenzo Raimondo, Giuseppe Murdaca, Virginia Caira, Erika Pigatto, Giovanna Cuomo, Alberto Lo Gullo, Ilaria Cavazzana, Corrado Campochiaro, Caterina Naclerio, Rossella De Angelis, Jacopo Ciaffi, Luana Mancarella, Veronica Brusi, Elena Marchetti, Francesca Motta, Marcella Visentini, Sebastiano Lorusso, Maria De Santis, Giacomo De Luca, Laura Massaro, Domenico Olivo, Roberta Pellegrini, Francesca Francioso, Jessica Maria Elisa Luppino, Ilenia Di Cola, Roberta Foti, Giuseppe Varcasia, Francesco Caso, Massimo Reta, Lorenzo Dagna, Carlo Selmi, Annamaria Iagnocco, Roberto Giacomelli, Florenzo Iannone, Clodoveo Ferri,
To better define the spectrum of new-onset post-COVID-19 and post-COVID-19 vaccine inflammatory rheumatic diseases (IRD) from a large multicentric observational study.Consecutive cases of IRD encountered during a 12-month period and satisfying one of the following inclusion criteria: (a) onset of the rheumatic manifestations within 4 weeks from SARS-CoV-2 infection or (b) onset of the rheumatic manifestations within 4 weeks from the administration of one of the COVID-19 vaccines ws recruited.The final ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2023 - BMJ | RMD Open
Produção Nacional
Revisado por pares
Antonio Vitale, Valeria Caggiano, Francesca Della Casa, José Hernández‐Rodríguez, Micol Frassi, Sara Monti, Abdurrahman Tufan, Salvatore Telesca, Edoardo Conticini, Gaafar Ragab, Giuseppe Lopalco, Ibrahim Almaghlouth, Rosa Maria Rodrigues Pereira, Derya Yıldırım, Marco Cattalini, Achille Marino, Teresa Giani, Francesco La Torre, Piero Ruscitti, Emma Aragona, Ewa Więsik‐Szewczyk, Emanuela Del Giudice, Petros P. Sfikakis, Marcello Govoni, Giacomo Emmi, Maria Cristina Maggio, Roberto Giacomelli, Francesco Ciccia, Giovanni Conti, Djouher Ait‐Idir, Claudia Lomater, Vito Sabato, Matteo Piga, Ali Şahin, Daniela Opriş-Belinski, Ruxandra Ionescu, Elena Bartoloni, Franco Franceschini, Paola Parronchi, Amato de Paulis, Gerard Espinosa, Armin Maier, Gian Domenico Sebastiani, Antonella Insalaco, Farhad Shahram, Paolo Sfriso, Francesca Minoia, Maria Alessio, Joanna Makowska, Gülen Hatemi, Nurullah Akkoç, Francesca Li Gobbi, Antonio Gidaro, Alma Nunzia Olivieri, Sulaiman M. Al‐Mayouf, Şükran Erten, Stefano Gentileschi, Ibrahim Vasi, Maria Tarsia, Ayman Abdel-Monem Ahmed Mahmoud, Bruno Frediani, Musa Alzahrani, Ahmed Hatem Laymouna, Francesca Ricci, Fabio Cardinale, Karina Jahnz‐Różyk, Gian Marco Tosi, Francesca Crisafulli, Alberto Balistreri, Marilia Ambiel Dagostin, Mahmoud Ghanema, Carla Gaggiano, Jurgen Sota, Ilenia Di Cola, Claudia Fabiani, Henrique Ayres Mayrink Giardini, Alessandra Renieri, Alessandra Fabbiani, Anna Carrer, Monica Bocchia, Federico Caroni, Donato Rigante, Luca Cantarini,
Objective The aim of this paper is to present the AutoInflammatory Disease Alliance (AIDA) international Registry dedicated to Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic (VEXAS) syndrome, describing its design, construction, and modalities of dissemination. Methods This Registry is a clinical, physician-driven, population- and electronic-based instrument designed for the retrospective and prospective collection of real-life data. Data gathering is based on the Research Electronic Data ...
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
2022 - Frontiers Media | Frontiers in Medicine
Francesco Ursini, Piero Ruscitti, Vincenzo Raimondo, Rossella De Angelis, Fabio Cacciapaglia, Erika Pigatto, Domenico Olivo, Ilenia Di Cola, Felice Galluccio, Francesca Francioso, Rosario Foti, Antonio Tavoni, Salvatore D’Angelo, Corrado Campochiaro, Francesca Motta, Maria De Santis, Silvia Bilia, Caterina Bruno, Giacomo De Luca, Marcella Visentini, Jacopo Ciaffi, Luana Mancarella, Veronica Brusi, Martina D’Onghia, Giovanna Cuomo, Enrico Fusaro, Paola Cipriani, Lorenzo Dagna, Serena Guiducci, Riccardo Melicòni, Florenzo Iannone, Annamaria Iagnocco, Roberto Giacomelli, Clodoveo Ferri,
Mass vaccination represented the game changer for the global battle against SARS-CoV-2, an unprecedented infectious threat for the world's population.Despite the insufficient coverage of low-income countries, more than 9 billion doses of vaccine have been administered to date, providing protection for ~ 50% of the world's population.Unfortunately, the vaccination campaign is still in danger by the diffusion of fake news disseminated, mainly through the
Tópico(s): Peripheral Neuropathies and Disorders
2022 - Springer Science+Business Media | Clinical Rheumatology
Gino Marioni, Elena Fasanaro, Niccolò Favaretto, Giacomo Trento, Luciano Giacomelli, Roberto Stramare, Giancarlo Ottaviano, Cosimo de Filippis,
Background: Deep neck infections (DNIs) are often clinically challenging, and may be life-threatening.Objective: The present retrospective study aimed to identify panels of clinical, laboratory, radiological, and microbiological parameters that could identify patients with DNIs at higher risk of complications or long-term hospitalization.Materials and methods: The investigation concerned 301 consecutive patients with DNIs treated at our institution between 2000 and 2014.Results: The discriminatory ...
Tópico(s): Streptococcal Infections and Treatments
2019 - Taylor & Francis | Acta Oto-Laryngologica
Angela Bisio, Gianluca Damonte, Emanuela Giacomelli, Giacomo Mele, Aldo Profumo, Giovanni Romussi, N. De Tommasi,
The surface exudate obtained by rinsing the aerial parts of Salvia adenophora with CH2Cl2 was subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to HPLC-MS followed by semi-preparative RP-HPLC. Some known diterpenes have been isolated together with a new clerodane diterpenoid 1, identified by IR, NMR, including TOCSY, COSY, HSQC, HMBC and ROESY experiments, ESI-TRAP-MS and HR-MS analysis.
Tópico(s): Essential Oils and Antimicrobial Activity
2012 - Thieme Medical Publishers (Germany) | Planta Medica
Kati Böhm, Giacomo Giacomelli, Fabian Meyer, Marc Bramkamp,
Corynebacterineae share an unusually complex cell envelope that discriminates species of this group markedly from other actinobacteria. Phylogenetically, they belong to the Gram-positives, but contain additionally to their peptidoglycan cell wall an extra cell envelope layer composed of arabinose and galactose polymers, the arabinogalactan. Covalently linked to the outer arabinose subunits are mycolic acids forming an inner leaflet of a membrane that is capped by trehalose mono- and dimycolates ...
Tópico(s): Genomics and Phylogenetic Studies
2020 - Springer Nature | Microbiology monographs
Alberto Rizzo, Federica Salari, Angelo Eplite, Andrea Giacomelli, Davide Moschese, Davide Dalu, Maria Vittoria Cossu, Rosaria Lorusso, Giacomo Pozza, Loriana Morelli, Cinzia Fasola, Claudia Tonielli, Chiara Fusetti, Valeria De Cristofaro, Andrea Gori, Alessandra Lombardi, Giuliano Rizzardini, Maria Rita Gismondo, Spinello Antinori,
Background Oral human papillomavirus (HPV) is common among healthy individuals but causes and implications of persistent infections are under evaluation in the pathogenesis of head and neck neoplasms.
Tópico(s): Oral Health Pathology and Treatment
2024 - Taylor & Francis | Infectious Diseases
Antonio Piralla, Davide Mileto, Alberto Rizzo, Guglielmo Ferrari, Federica Giardina, Stefano Gaiarsa, Greta Petazzoni, Micol Bianchi, Federica Salari, Fiorenza Bracchitta, José Camilla Sammartino, Alessandro Ferrari, Gloria Gagliardi, Alessandro Mancon, Claudio Fenizia, Mara Biasin, Francesca Rovida, Stefania Paolucci, Elena Percivalle, Alessandra Lombardi, Valeria Micheli, Silvia Nozza, Antonella Castagna, Davide Moschese, Spinello Antinori, Andrea Gori, Paolo Bonfanti, Roberto Rossotti, Antonella d’Arminio Monforte, Federica Attanasi, Marcello Tirani, Danilo Cereda, Fausto Baldanti, Maria Rita Gismondo, Miriam Cutrera, Marianna Cuomo, Federica De Poli, Giulia Campanini, Antonino Maria Guglielmo Pitrolo, Elizabeth Iskandar, Irene Cassaniti, Raffaele Bruno, Giuliano Rizzardini, Massimo Puoti, Francesco Castelli, Laura Corsico, Andrea Giacomelli, Giacomo Pozza, Giacomo Casalini, Angelo Roberto Raccagni, Bendetta Trentacapilli, Costanza Bertoni, Elena Bruzzesi, Caterina Candela, Daniele Tesoro, Giovanni Mulè, Alessandra Bandera, Antonio Muscatello Bianca Mariani, Manuel Maffeo, Riccardo Vecchio, Sara Piccinelli,
Mpox virus (MPXV) has recently spread outside of sub-Saharan Africa. This large multicentre study was conducted in Lombardy, the most densely populated Italian region accounting for more than 40% of Italian cases. The present study aims to: i) evaluate the presence and the shedding duration of MPXV DNA in different body compartments correlating the MPXV viability with the time to onset of symptoms; ii) provide evidence of MPXV persistence in different body compartment as a source of infection and ...
Tópico(s): Herpesvirus Infections and Treatments
2024 - Elsevier BV | Travel Medicine and Infectious Disease
Produção Nacional
Revisado por pares
L. A. Bissell, Daniel E. Fürst, S. Johnson, Peter Hansen, E. Recalde, D. Khanna, F. Del Galdo,
... Giovanna Cuomo, Maurizio Cutolo, Laszlo Czirjak, Lorenzo Dagna, Giacomo De Luca, Nicoletta Del Papa, Christopher Denton, Emma Derrett-Smith, Robyn Domsic, Raluca-Bianca Dumitru, Victoria Flower, Ivan Foeldvari, Armando Gabrielli, Yasir Ghaffar, Roberto Giacomelli, Dilia Giuggioli, Daisy Gonzalez, Jessica Gordon, Yvonne Gouldstone, ...
Tópico(s): Systemic Sclerosis and Related Diseases
2022 - BMJ | Annals of the Rheumatic Diseases
Andrea De Vito, Alessandro Tavelli, Alessandro Cozzi‐Lepri, Andrea Giacomelli, Roberto Rossotti, Giacomo Ponta, Nicoletta Bobbio, Alice Ianniello, Antonella Cingolani, Giordano Madeddu, Andrea Antinori, Antonella d’Arminio Monforte,
Tópico(s): HIV-related health complications and treatments
2025 - Wiley | HIV Medicine
... artwork of Auguste Rodin, Eva Hesse, and Francisco de Zurbarán, as well as the sensual ultra-philosophy of Giacomo Leopardi’s lyrical poetry in relation to the stark black-and-white photography of Mario Giacomelli, and, last but not least, the distinctions between ...
2022 - Modern Humanities Research Association | The Modern Language Review
Karin Schubert, Boris Sieger, Fabian Meyer, Giacomo Giacomelli, Kati Böhm, Angela Rieblinger, Laura Lindenthal, Nadja Sachs, Gerhard Wanner, Marc Bramkamp,
Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved among all CMN group bacteria. The arabinogalactan and mycolic acid synthesis pathways constitute effective drug targets for tuberculosis treatment. Ethambutol (EMB), a classical antituberculosis ...
Tópico(s): Glycosylation and Glycoproteins Research
2017 - American Society for Microbiology | mBio
Kati Böhm, Giacomo Giacomelli, Andreas Schmidt, Axel Imhof, Romain Koszul, Martial Marbouty, Marc Bramkamp,
Abstract Higher-order chromosome folding and segregation are tightly regulated in all domains of life. In bacteria, details on nucleoid organization regulatory mechanisms and function remain poorly characterized, especially in non-model species. Here, we investigate the role of DNA-partitioning protein ParB and SMC condensin complexes in the actinobacterium Corynebacterium glutamicum . Chromosome conformation capture reveals SMC-mediated long-range interactions around ten centromere-like parS sites ...
Tópico(s): RNA and protein synthesis mechanisms
2020 - Nature Portfolio | Nature Communications
Manuel Osorio‐Valeriano, Florian Altegoer, Chandan K. Das, Wieland Steinchen, Gaël Panis, Lara Connolley, Giacomo Giacomelli, Helge Feddersen, Laura Corrales‐Guerrero, Pietro I. Giammarinaro, Juri Hanßmann, Marc Bramkamp, Patrick H. Viollier, Seán Murray, Lars V. Schäfer, Gert Bange, Martin Thanbichler,
ParB-like CTPases mediate the segregation of bacterial chromosomes and low-copy number plasmids. They act as DNA-sliding clamps that are loaded at parS motifs in the centromere of target DNA molecules and spread laterally to form large nucleoprotein complexes serving as docking points for the DNA segregation machinery. Here, we solve crystal structures of ParB in the pre- and post-hydrolysis state and illuminate the catalytic mechanism of nucleotide hydrolysis. Moreover, we identify conformational ...
Tópico(s): Antibiotic Resistance in Bacteria
2021 - Elsevier BV | Molecular Cell
Giacomo Giacomelli, Helge Feddersen, Peng Feng, Gustavo Benevides Martins, Manuela Grafemeyer, Fabian Meyer, Benjamin Mayer, Peter L. Graumann, Marc Bramkamp,
In order to survive, bacterial cells rely on precise spatiotemporal organization and coordination of essential processes such as cell growth, chromosome segregation, and cell division. Given the general lack of organelles, most bacteria are forced to depend on alternative localization mechanisms, such as, for example, geometrical cues. DivIVA proteins are widely distributed in mainly Gram-positive bacteria and were shown to bind the membrane, typically in regions of strong negative curvature, such ...
Tópico(s): Bacteriophages and microbial interactions
2022 - Multidisciplinary Digital Publishing Institute | Genes
Dario Cattaneo, Andrea Giacomelli, Giacomo Casalini, Anna Lisa Ridolfo, Cristina Gervasoni,
Tópico(s): HIV Research and Treatment
2024 - Springer Science+Business Media | European Journal of Clinical Pharmacology
Giuseppe Lopalco, Vincenzo Venerito, Antonio Brucato, Giacomo Emmi, Roberto Giacomelli, Alberto Cauli, Matteo Piga, Paola Parronchi, Mariangela Nivuori, Danilo Malandrino, Piero Ruscitti, Gianfranco Vitiello, Claudia Fabiani, Luca Cantarini, Florenzo Iannone,
La polysérite est une affection inflammatoire touchant simultanément plusieurs membranes séreuses, à savoir le péricarde, la plèvre et le péritoine, avec un épanchement dans les cavités respectives. Les anti-inflammatoires non stéroïdiens (AINS), la colchicine et les glucocorticoïdes peuvent se montrer efficaces sur la polysérite, mais les rechutes sont fréquentes lors de la diminution ou de l’arrêt de ces traitements. L’antagoniste du récepteur de l’interleukine (IL)-1 anakinra a présenté un effet ...
Tópico(s): Streptococcal Infections and Treatments
2022 - Elsevier BV | Revue du Rhumatisme
Produção Nacional
Revisado por pares
Piero Ruscitti, Ilenia Di Cola, Antonio Vitale, Valeria Caggiano, Pierpaolo Palumbo, Ernesto Di Cesare, Jiram Torres-Ruíz, Guillermo Arturo Guaracha-Basáñez, Eduardo Martín‐Nares, Francesco Ciccia, Daniela Iacono, Flavia Riccio, Maria Cristina Maggio, Samar Tharwat, Soad Hashad, Donato Rigante, Augusta Ortolan, Henrique Ayres Mayrink Giardini, Isabele Parente de Brito Antonelli, Rafael Alves Cordeiro, Roberto Giacomelli, Luca Navarini, Onorina Berardicurti, Alessandro Conforti, Daniela Opriş-Belinski, Jurgen Sota, Carla Gaggiano, Giuseppe Lopalco, Florenzo Iannone, Francesco La Torre, Violetta Mastrorilli, Marcello Govoni, Francesca Ruffilli, Giacomo Emmi, Edoardo Biancalana, Petros P. Sfikakis, Maria G. Tektonidou, José Hernández‐Rodríguez, Verónica Gómez‐Caverzaschi, Özgül Soysal Gündüz, Giovanni Conti, Serena Patroniti, Antonio Gidaro, Arianna Bartoli, Alma Nunzia Olivieri, Maria Francesca Gicchino, Antonio Brucato, Lorenzo Dagna, Alessandro Tomelleri, Corrado Campochiaro, Amato de Paulis, Ilaria Mormile, Francesca Della Casa, Haner Direşkeneli, Fatma Alıbaz-Öner, Αναστάσιος Καραμανάκος, Aikaterini Dimouli, Gaafar Ragab, Ayman Abdel-Monem Ahmed Mahmoud, Abdurrahman Tufan, Hamit Küçük, Rıza Can Kardaş, Ezgi Deniz Batu, Seza Özen, Ewa Więsik–Szewczyk, Andrea Hinojosa‐Azaola, Alberto Balistreri, Claudia Fabiani, Bruno Frediani, Luca Cantarini,
To evaluate the cardiac involvement in patients with Still's disease with a focus on myocarditis included in the multicenter AIDA (AutoInflammatory Disease Alliance) network Still's disease registry. To exploit the predictive factors for myocarditis in deriving a clinical risk patient profile for this severe manifestation.
Tópico(s): Transplantation: Methods and Outcomes
2024 - The Journal of Rheumatology Publishing Company Limited | The Journal of Rheumatology