Produção Nacional
Marcela Charantola Rodrigues, Thiago Lewis Reis Hewer, Giancarlo Espósito de Souza Brito, Victor E. Arana‐Chavez, Roberto Ruggiero Braga,
The synthesis of calcium phosphate nanoparticles may include modifying agents to tailor particle size, reduce agglomeration and add specific functionalities. This study describes the synthesis of dicalcium phosphate dihydrate (DCPD) nanoparticles functionalized with triethylene glycol dimethacrylate (TEGDMA), added to one of the reacting solutions, with the purpose of reducing agglomeration and improving the compatibility with vinyl-based resin matrices. The nanoparticles were characterized by X-ray ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2014 - Elsevier BV | Materials Science and Engineering C
Produção Nacional
Revisado por pares
Javier Bustamante Mamani, Lionel Fernel Gamarra, Giancarlo Espósito de Souza Brito,
Nowadays the use of magnetic nanoparticles (MNP) in medical applications has exceeded expectations. In molecular imaging, MNP based on iron oxide coated with appropriated materials have several applications in vitro and in vivo studies. For applications in nanobiotechnology these MNP must present some characteristics such as size smaller than 100 nanometers, high magnetization values, among others. Therefore the MNP have physical and chemical properties that are specific to certain studies which ...
Tópico(s): Iron oxide chemistry and applications
2014 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research
Produção Nacional
Revisado por pares
André Felipe Henriques Librantz, L. Gomes, S.L. Baldochi, I.M. Ranieri, Giancarlo Espósito de Souza Brito,
Tópico(s): Glass properties and applications
2006 - Elsevier BV | Journal of Luminescence
Produção Nacional
Revisado por pares
Giancarlo Espósito de Souza Brito, Celso V. Santilli, Sandra H. Pulcinelli,
The structural evolution during sintering of compacted SnO2 sol-gel powder was investigated using nitrogen adsorption isotherm analysis. Results show that for sintering temperatures up to 400°C the samples have a fractal pore size distribution. As the sintering temperature increases, a structural rearragement occurs, allowing an increase of the efficiency of particle packing and the reduction of fractality. Above 400°C, the pore size growth associated with grain coalescence is the main structural ...
Tópico(s): Granular flow and fluidized beds
1995 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects
Giancarlo Esposito, S. Romano, Martien A. Hulsen, Gaetano D’Avino, Massimiliano M. Villone,
The dynamics of a cell suspended in a Newtonian liquid subjected to a pressure-driven flow at non-negligible inertia in cylindrical and square cross section microfluidic channels is studied through three-dimensional arbitrary Lagrangian–Eulerian finite-element numerical simulations. The cell is modeled through the neo-Hookean hyper-elastic constitutive equation, which can describe biological particles undergoing moderate deformations. The cell-to-channel relative dimension is fixed to 0.2, whereas ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2022 - American Institute of Physics | Physics of Fluids
Produção Nacional
Revisado por pares
J. Mantilla, V. Bindilatti, E. ter Haar, J. A. H. Coaquira, Giancarlo Espósito de Souza Brito, X. Gratens, V. Sagredo,
We present measurements of the magnetic and structural properties of the magnetic semiconductor MnIn2Se4 and Zn1−xMnxIn2Se4(x=0.87). The localized Mn ions in the layered rhombohedral structure undergo a spin-freezing transition below 3.5K. The frequency-dependent freezing temperature Tf varies as ΔTf/(TfΔlogω)≈0.022, indicating spin-glass behavior.
Tópico(s): Phase-change materials and chalcogenides
2004 - Elsevier BV | Journal of Magnetism and Magnetic Materials
Produção Nacional
Revisado por pares
Giancarlo Espósito de Souza Brito, Sandra H. Pulcinelli, Celso V. Santilli,
Tópico(s): Transition Metal Oxide Nanomaterials
1994 - Springer Science+Business Media | Journal of Sol-Gel Science and Technology
Anna Palmisano, Davide Vignale, Marijana Tadić, Francesco Moroni, Domenico De Stefano, Marco Gatti, Edda Boccia, Riccardo Faletti, Michele Oppizzi, Giovanni Peretto, Massimo Slavich, Simone Sala, Matteo Montorfano, Eustachio Agricola, Alberto Margonato, Francesco De Cobelli, Francesco Gentile, Manuela Robella, Giancarlo Cortese, Antonio Esposito,
Background Acute chest pain with mild troponin rise and inconclusive diagnosis after clinical evaluation represents a diagnostic challenge. Triple-rule-out (TRO) CT may exclude coronary artery disease (CAD), as well as acute aortic syndrome and pulmonary embolism, but cannot help identify other causes of myocardial injury. Purpose To investigate the diagnostic value of a comprehensive CT protocol including both an angiographic and a late contrast enhancement (LCE) scan in participants with troponin- ...
Tópico(s): Pericarditis and Cardiac Tamponade
2021 - Radiological Society of North America | Radiology
Laura Ferrè, Arturo Nuara, Giulia Pavan, Marta Radaelli, Lucia Moiola, Mariaemma Rodegher, B. Colombo, Ignacio Juan Keller Sarmiento, Vittorio Martinelli, Letizia Leocani, Filippo Martinelli Boneschi, Gıancarlo Comı, Federica Esposito,
Tópico(s): Ginseng Biological Effects and Applications
2015 - Springer Science+Business Media | Neurological Sciences
Aurora Daniele, Iris Scala, Giuseppe Cardillo, Cinzia Pennino, Carla Ungaro, Michelina Sibilio, Giancarlo Parenti, Luciana Esposito, Adriana Zagari, Generoso Andria, Francesco Salvatore,
Hyperphenylalaninemia (Online Mendelian Inheritance in Man database: 261600) is an autosomal recessive disorder mainly due to mutations in the gene for phenylalanine hydroxylase; the most severe form of hyperphenylalaninemia is classic phenylketonuria. We sequenced the entire gene for phenylalanine hydroxylase in 51 unrelated hyperphenylalaninemia patients from Southern Italy. The entire locus was genotyped in 46 out of 51 hyperphenylalaninemia patients, and 32 different disease-causing mutations ...
Tópico(s): Metabolomics and Mass Spectrometry Studies
2009 - Wiley | FEBS Journal
Claudio Baraldi, Giancarlo Corsi, Elena Esposito,
Tópico(s): Public Administration and Political Analysis
1999 - Cambridge University Press | Tijdschrift voor Philosophie
P. Brizzi, Giancarlo Tonolo, Franca Esposito, Loreta Puddu, Salvatore Dessole, Mario Maioli, S Milia,
We sought to investigate the changes in circulating serum lipids and lipoproteins, including lipoprotein (a), and low-density lipoprotein size in women during normal pregnancy.Twenty-two women (mean age, 31 +/- 5 years; 13 primiparous subjects) were studied during uncomplicated pregnancy with normal outcome. Twenty-four nulliparous women of similar age (31 +/- 4 years) were studied as control subjects.Serum triglycerides and total and low-density lipoprotein cholesterol increased significantly during pregnancy ...
Tópico(s): Birth, Development, and Health
1999 - Elsevier BV | American Journal of Obstetrics and Gynecology
Giovanni Battista Ratto, S. Toma, D Civalleri, Giancarlo Passerone, Mauro Esposito, D Zaccheo, Marco Canepa, P. Romano, Raffaella Palumbo, Franco De Cian, F Scarano, Maria O. Vannozzi, Elisabetta Spessa, G. Fantino,
Abstract A multimodality approach including operation and isolated lung perfusion with platinum was used in six patients with lung metastases from soft tissue sarcomas. Staged thoracotomies were used in two patients with bilateral lesions. The inclusion criteria generally applied for surgical excision were adopted in this study. The pulmonary artery and a portion of the left atrium were isolated from systemic circulation and cannulated. The cannulas were then connected to a perfusion circuit and normothermic ...
Tópico(s): Lung Cancer Diagnosis and Treatment
1996 - Elsevier BV | Journal of Thoracic and Cardiovascular Surgery
Giancarlo Esposito, Yannis Dimakopoulos, John Tsamopoulos,
We study the motion of a viscous drop rising in a viscoelastic liquid that exhibits elastic and shear thinning effects and is represented by the exponential PTT constitutive model. We validate the numerical formulation and solution method by comparing our predictions with previous experimental data, and we find quantitative agreement in terminal velocities and drop shapes. The interplay of viscous, elastic, and capillary forces is examined through an extensive parametric study. Increasing material ...
Tópico(s): Fluid Dynamics and Thin Films
2023 - Elsevier BV | Journal of Non-Newtonian Fluid Mechanics
Bruno L. Giordano, Michele Esposito, Giancarlo Valente, Elia Formisano,
Abstract Recognizing sounds implicates the cerebral transformation of input waveforms into semantic representations. Although past research identified the superior temporal gyrus (STG) as a crucial cortical region, the computational fingerprint of these cerebral transformations remains poorly characterized. Here, we exploit a model comparison framework and contrasted the ability of acoustic, semantic (continuous and categorical) and sound-to-event deep neural network representation models to predict ...
Tópico(s): Music and Audio Processing
2023 - Nature Portfolio | Nature Neuroscience
Maria Francesca Freda, Raffaele De Luca Picione, Giovanna Esposito, Giancarlo Ragozini, Italo Testa,
Abstract Despite the growing interest on the notion of academic engagement (AE) and its relevance for students’ success, a few valid and reliable instruments on AE have been developed. Moreover, most of the available measures consider AE as a student’s trait rather than a relational and situated dynamic process. This study presents the development and validation of a new instrument, the SInAPSi Academic Engagement Scale (SAES), which was developed within a project coordinated by the SInAPSi center ...
Tópico(s): Education, Achievement, and Giftedness
2021 - Springer Science+Business Media | Current Psychology
Xiaoming Jia, Lohith Madireddy, Stacy J. Caillier, Adam Santaniello, Federica Esposito, Gıancarlo Comı, Olaf Stüve, Yuan Zhou, Bruce Taylor, Trevor J. Kilpatrick, Filippo Martinelli Boneschi, Bruce Cree, Jorge R. Oksenberg, Stephen L. Hauser, Sergio E. Baranzini,
Primary progressive multiple sclerosis (PPMS) causes accumulation of neurological disability from disease onset without clinical attacks typical of relapsing multiple sclerosis (RMS). However, whether genetic variation influences the disease course remains unclear. We aimed to determine whether mutations causative of neurological disorders that share features with multiple sclerosis (MS) contribute to risk for developing PPMS.
Tópico(s): Cytokine Signaling Pathways and Interactions
2018 - Wiley | Annals of Neurology
Carmen Barba, Nicola Specchio, Renzo Guerrini, Laura Tassi, Salvatore De Masi, Francesco Cardinale, Simona Pellacani, Luca De Palma, Domenica Battaglia, Gianpiero Tamburrini, Giuseppe Didato, Elena Freri, Alessandro Consales, Paolo Nozza, Nelia Zamponi, Elisabetta Cesaroni, Giancarlo Di Gennaro, Vincenzo Esposito, Marco Giulioni, Paolo Tinuper, Gabriella Colicchio, Raffaele Rocchi, Guido Rubboli, Flavio Giordano, Giorgio Lo Russo, Carlo Efisio Marras, Massimo Cossu,
Abstract Objective The objective of the study was to assess common practice in pediatric epilepsy surgery in Italy between 2008 and 2014. Methods A survey was conducted among nine Italian epilepsy surgery centers to collect information on presurgical and postsurgical evaluation protocols, volumes and types of surgical interventions, and etiologies and seizure outcomes in pediatric epilepsy surgery between 2008 and 2014. Results Retrospective data on 527 surgical procedures were collected. The most frequent ...
Tópico(s): Glioma Diagnosis and Treatment
2017 - Elsevier BV | Epilepsy & Behavior
Giuseppe Curigliano, Davide Disalvatore, Alessandro Esposito, Giancarlo Pruneri, Matteo Lazzeroni, Aliana Guerrieri‐Gonzaga, Alberto Luini, Roberto Orecchia, Aron Goldhirsch, Nicole Rotmensz, Bernardo Bonanni, Giuseppe Viale,
HER2 overexpression in primary ductal carcinomain situ (DCIS) was associated with a higher risk of in situ recurrence. No association with a higher risk of invasive breast cancer recurrence was observed. Our data have shown a clear benefit from radiotherapy in HER2-positive DCIS.BackgroundTo assess the prognostic role of human epidermal growth factor receptor 2 (HER2) overexpression in patients with ductal carcinomain situ (DCIS).Patients and methodsWe identified patients with HER2-positive DCIS among ...
Tópico(s): Cancer Treatment and Pharmacology
2015 - Elsevier BV | Annals of Oncology
Anand M. Iyer, Emanuele Zurolo, Karin Boer, Johannes C. Baayen, Felice Giangaspero, Antonietta Arcella, Giancarlo Di Gennaro, Vincenzo Esposito, Wim G.M. Spliet, P.C. van Rijen, Dirk Troost, Jan A. Gorter, Eleonora Aronica,
A growing body of evidence demonstrates the involvement of plasminogen activators (PAs) in a number of physiologic and pathologic events in the CNS. Induction of both tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA) has been observed in different experimental models of epilepsy and tPA has been implicated in the mechanisms underlying seizure activity. We investigated the expression and the cellular distribution of tPA and uPA in several epileptogenic pathologies, including ...
Tópico(s): Parasite Biology and Host Interactions
2010 - Elsevier BV | Neuroscience
Eleonora Palma, Davide Ragozzino, Silvia Di Angelantonio, Addolorata Mascia, Francesca Maiolino, M. Manfredi, Giampaolo Cantore, Vincenzo Esposito, Giancarlo Di Gennaro, P. P. Quarato, Ricardo Miledi, Fabrizio Eusebi,
Summary: Purpose: GABA A receptors from the brain of patients afflicted with mesial temporal lobe epilepsy (MTLE) become less efficient (run‐down) when repetitively activated by GABA. Experiments were designed to investigate whether the antiepileptic drug, levetiracetam (LEV), which is used as an adjunctive treatment for medically intractable MTLE, counteracts the GABA A receptor run‐down. Methods: GABA A receptors were microtransplanted from the brains of patients afflicted with MTLE into Xenopus ...
Tópico(s): Lipid Membrane Structure and Behavior
2007 - Wiley | Epilepsia
Liliana G. Grammaldo, T. Giampà, Pier Paolo Quarato, Angelo Picardi, Addolorata Mascia, Antonio Sparano, G Meldolesi, Fabio Sebastiano, Vincenzo Esposito, Giancarlo Di Gennaro,
Our aim was to test the lateralizing value of a neuropsychological battery including several memory tests on a large sample of consecutive patients with drug‐resistant temporal lobe epilepsy (TLE) evaluated for epilepsy surgery. We studied 73 right‐handed patients (56% males, mean age 35.3 ± 11.2 years, 49% left TLE) aged 16 years or older with normal IQ who underwent a preoperative neuropsychological assessment including several memory tests and were seizure‐free after at least 1 year of follow‐up. ...
Tópico(s): Neuroscience and Neuropharmacology Research
2006 - Wiley | European Journal of Neurology
Fabio Sebastiano, Giancarlo Di Gennaro, Vincenzo Esposito, Angelo Picardi, Roberta Morace, Antonio Sparano, Addolorata Mascia, Claudio Colonnese, Giuseppe Cantore, Pier Paolo Quarato,
To evaluate a novel method for localization of subdural electrodes in presurgical assessment of patients with drug-resistant focal epilepsy. We studied eight consecutive patients with posterior epilepsy in whom subdural electrodes were implanted for presurgical evaluation. Electrodes were detected on post-implantation brain CT scans through a semiautomated procedure based on a MATLAB routine. Then, post-implantation CT scans were fused with pre-implantation MRI to localize the electrodes in relation ...
Tópico(s): Neuroscience and Neuropharmacology Research
2006 - Elsevier BV | Clinical Neurophysiology
Addolorata Mascia, Giancarlo Di Gennaro, Vincenzo Esposito, Liliana G. Grammaldo, G Meldolesi, T. Giampà, Fabio Sebastiano, Carolina De Falco, Paolo Onorati, M. Manfredi, Giampaolo Cantore, Pier Paolo Quarato,
Genital and sexual manifestations represent rare clinical phenomena during or after focal seizures. The semiology of these types of automatisms is controversial. In particular, it is unclear whether temporal or frontal structures are involved in their generation and whether these clinical manifestations have a potential lateralizing value. In this view, from a population of 212 consecutive patients with drug resistant focal epilepsy referred to us for presurgical assessment, we retrospectively identified ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2005 - Elsevier BV | Seizure
Alberto Verrotti, Daniela Laino, Victoria Elisa Rinaldi, Agnese Suppiej, Lucio Giordano, Irene Toldo, Lucia Margari, Pasquale Parisi, Renata Rizzo, Sara Matricardi, Raffaella Cusmai, Salvatore Grosso, R. Gaggero, Nicola Zamponi, Piero Pavone, Giuseppe Capovilla, Markus Rauchenzauner, Caterina Cerminara, Giancarlo Di Gennaro, Maria Esposito, Pasquale Striano, Salvatore Savasta, Giangennaro Coppola, Sabrina Siliquini, Francesca Felicia Operto, Vincenzo Belcastro, Francesca Ragona, Gian Luigi Marseglia, Alberto Spalice,
Our aim was to describe the clinical and electrical features and the long-term evolution of childhood occipital epilepsy of Gastaut (COE-G) in a cohort of patients and to compare long-term prognosis between patients with and without other epileptic syndromes.This was a retrospective analysis of the long-term outcome of epilepsy in 129 patients with COE-G who were referred to 23 Italian epilepsy centres and one in Austria between 1991 and 2004. Patients were evaluated clinically and with electroencephalograms ...
Tópico(s): Neonatal and fetal brain pathology
2015 - Wiley | European Journal of Neurology
Maurits Sanders, Iskander Van der Wolf, Floor E. Jansen, Eleonora Aronica, Christoph Helmstaedter, Áttila Rácz, Rainer Surges, Alexander Grote, Albert J. Becker, Sylvain Rheims, Hélène Catenoix, John S. Duncan, Jane de Tisi, Thomas S. Jacques, J. Helen Cross, Reetta Kälviäinen, Tuomas Rauramaa, Francine Chassoux, Bertrand Devaux, Giancarlo Di Gennaro, Vincenzo Esposito, István Bódi, Mrinalini Honavar, Christian G. Bien, Thomas Cloppenborg, Roland Coras, Hajo M. Hamer, Petr Marusič, Adam Kalina, Tom Pieper, Manfred Kudernatsch, Till Hartlieb, Tim J. von Oertzen, Martin Aichholzer, Georg Dorfmüller, Mathilde Chipaux, Soheyl Noachtar, Elisabeth Kaufmann, Andreas Schulze‐Bonhage, Christian Scheiwe, Çiğdem Özkara, Thomas Grünwald, Kristina Koenig, Renzo Guerrini, Carmen Barba, Anna Maria Buccoliero, Flavio Giordano, Felix Rosenow, Katja Menzler, Rita Garbelli, Francesco Deleo, Pavel Kršek, Barbora Straka, Alexis Arzimanoglou, Joseph Toulouse, Wim Van Paesschen, Tom Theys, José Pimentel, Isabel Amorim, Nicola Specchio, Luca De Palma, Martha Feucht, Theresa O. Scholl, Karl Roessler, Rafael Toledano, António Gil‐Nagel, Savo Raičević, Aleksandar J. Ristić, Olaf Schijns, Jan Beckervordersandforth, Victoria San Antonio‐Arce, Jordi Rumià, Ingmar Blümcke, Kees P. J. Braun,
Patients with presumed nonlesional focal epilepsy-based on either MRI or histopathologic findings-have a lower success rate of epilepsy surgery compared with lesional patients. In this study, we aimed to characterize a large group of patients with focal epilepsy who underwent epilepsy surgery despite a normal MRI and had no lesion on histopathology. Determinants of their postoperative seizure outcomes were further studied.
Tópico(s): Neuroscience and Neuropharmacology Research
2024 - Lippincott Williams & Wilkins | Neurology
Gabriele Sciacca, Petra Martini, Sara Cisternino, Liliana Mou, Jonathan Amico, J. Esposito, Giancarlo Gorgoni, Emiliano Cazzola,
Cyclotron-based radionuclides production by using solid targets has become important in the last years due to the growing demand of radiometals, e.g.,
Tópico(s): Advanced Materials Characterization Techniques
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Nikolaos A. Patsopoulos, Sergio E. Baranzini, Adam Santaniello, Parisa Shoostari, Chris Cotsapas, Garrett Wong, Ashley Beecham, Tojo James, Joseph M. Replogle, Ioannis S. Vlachos, Cristin McCabe, Tune H. Pers, Aaron Brandes, Charles C. White, Brendan T Keenan, Maria Cimpean, Phoebe A. Winn, Ioannis-Pavlos Panteliadis, Allison Robbins, Till F. M. Andlauer, Onigiusz Zarzycki, Bénédicte Dubois, An Goris, Helle Bach Søndergaard, Finn Sellebjerg, Per Soelberg Sorensen, Henrik Ullum, Lise Wegner Thørner, Janna Saarela, Isabelle Cournu‐Rebeix, Vincent Damotte, Bertrand Fontaine, Léna Guillot‐Noël, Mark Lathrop, Sandra Vukusic, Achim Berthele, Viola Pongratz, Dorothea Buck, Christiane Gasperi, Christiane Graetz, Verena Grummel, Bernhard Hemmer, Muni Hoshi, Benjamin Knier, Thomas Korn, Christina M. Lill, Felix Luessi, Mark Mühlau, Frauke Zipp, Efthimios Dardiotis, Cristina Agliardi, Antonio Amoroso, Nadia Barizzone, Maria Donata Benedetti, Luisa Bernardinelli, Paola Cavalla, Ferdinando Clarelli, Gıancarlo Comı, Daniele Cusi, Federica Esposito, Laura Ferrè, Daniela Galimberti, Clara Guaschino, Maurizio Leone, Vittorio Martinelli, Lucia Moiola, Marco Salvetti, Melissa Sorosina, Domizia Vecchio, Andrea Zauli, Silvia Santoro, Nicasio Mancini, Miriam Zuccalà, Julia Mescheriakova, Cornelia M. van Duijn, Steffan D. Bos, Elisabeth Gulowsen Celius, Anne Spurkland, Manuel Comabella, Xavier Montalbán, Lars Alfredsson, Izaura Lima Bomfim, David Gómez-Cabrero, Jan Hillert, Maja Jagodic, Magdalena Lindén, Fredrik Piehl, Ilijas Jelc̆ić, Roland Martinꝉ, Mirela Sospedra, Amie Baker, Maria Ban, Clive Hawkins, Pirro G. Hysi, Seema Kalra, Fredrik Karpe, Jyoti Khadake, Geneviève Lachance, Paul Molyneux, Matthew Neville, John Thorpe, Elizabeth M. Bradshaw, Stacy J. Caillier, Peter A. Calabresi, Bruce Cree, Anne Cross, Mary F. Davis, Paul W. I. de Bakker, Silvia Delgado, Marieme Dembele, Keith R. Edwards, Kate Fitzgerald, Irene Y. Frohlich, Pierre‐Antoine Gourraud, Jonathan L. Haines, Hákon Hákonarson, Dorlan Kimbrough, Noriko Isobe, Ioanna Konidari, Ellen Lathi, Michelle Lee, Taibo Li, David An, Andrew Zimmer, Lohith Madireddy, Clara P. Manrique, Mitja Mitrovič, Marta Olah, Ellis Patrick, Margaret A. Pericak‐Vance, Laura Piccio, Cathy Schaefer, Howard L. Weiner, Kasper Lage, Alastair Compston, D Hafler, Hanne F. Harbo, Stephen L. Hauser, Graeme J. Stewart, Sandra D’Alfonso, Georgios Hadjigeorgiou, Bruce Taylor, Lisa F. Barcellos, David R. Booth, Rogier Hintzen, Ingrid Kockum, Filippo Martinelli Boneschi, Jacob L. McCauley, Jorge R. Oksenberg, Annette Oturai, Stephen Sawcer, Adrian J. Ivinson, Tomas Olsson, Philip L. De Jager,
We analyzed genetic data of 47,429 multiple sclerosis (MS) and 68,374 control subjects and established a reference map of the genetic architecture of MS that includes 200 autosomal susceptibility variants outside the major histocompatibility complex (MHC), one chromosome X variant, and 32 variants within the extended MHC. We used an ensemble of methods to prioritize 551 putative susceptibility genes that implicate multiple innate and adaptive pathways distributed across the cellular components of ...
Tópico(s): Atherosclerosis and Cardiovascular Diseases
2019 - American Association for the Advancement of Science | Science
Melissa Sorosina, Ferdinando Clarelli, Laura Ferrè, Ana Maria Osiceanu, Nermin Ünal, Elisabetta Mascia, Vittorio Martinelli, Gıancarlo Comı, Fabio Benigni, Federica Esposito, Filippo Martinelli Boneschi,
Nabiximols (Sativex® ) is a cannabinoid-based compound used for the treatment of moderate to severe spasticity in multiple sclerosis (MS). The aim of the study was to investigate the effect of the administration of Nabiximols on blood transcriptome profile of patients with MS and to interpret it in the context of pathways and networks.Whole-genome expression profiling was performed in whole blood of 33 subjects with MS at baseline and after 4 weeks of drug treatment. Patients were classified as responders ( ...
Tópico(s): Ginseng Biological Effects and Applications
2018 - Wiley | European Journal of Neurology
Mitja Mitrovič, Nikolaos A. Patsopoulos, Ashley Beecham, Theresa Dankowski, An Goris, Bénédicte Dubois, Marie D’hooghe, Robin Lemmens, Philip Van Damme, Helle Bach Søndergaard, Finn Sellebjerg, Per Soelberg Sorensen, Henrik Ullum, Lise Wegner Thørner, Thomas Werge, Janna Saarela, Isabelle Cournu‐Rebeix, Vincent Damotte, Bertrand Fontaine, Léna Guillot‐Noël, Mark Lathrop, Sandra Vukusik, Pierre‐Antoine Gourraud, Till F. M. Andlauer, Viola Pongratz, Dorothea Buck, Christiane Gasperi, Antonios Bayas, Christoph Heesen, Tania Kümpfel, Ralf A. Linker, Friedemann Paul, Martin Stangel, Björn Tackenberg, Florian Then Bergh, Clemens Warnke, Heinz Wiendl, Brigitte Wildemann, Uwe K. Zettl, Ulf Ziemann, Hayrettin Tumani, Ralf Gold, Verena Grummel, Bernhard Hemmer, Benjamin Knier, Christina M. Lill, Felix Luessi, Efthimios Dardiotis, Cristina Agliardi, Nadia Barizzone, Elisabetta Mascia, Luisa Bernardinelli, Giancarlo Comi, Daniele Cusi, Federica Esposito, Laura Ferrè, Cristoforo Comi, Daniela Galimberti, Maurizio Leone, Melissa Sorosina, Julia Mescheriakova, Rogier Hintzen, Cornelia M. van Duijn, Charlotte E. Teunissen, Steffan D. Bos, Kjell‐Morten Myhr, Elisabeth Gulowsen Celius, Benedicte A. Lie, Anne Spurkland, Manuel Comabella, Xavier Montalbán, Lars Alfredsson, Pernilla Stridh, Jan Hillert, Maja Jagodic, Fredrik Piehl, Ilijas Jelc̆ić, Roland Martinꝉ, Mireia Sospedra, Maria Ban, Clive Hawkins, Pirro G. Hysi, Seema Kalra, Fredrik Karpe, Jyoti Khadake, Geneviève Lachance, Matthew Neville, Adam Santaniello, Stacy J. Caillier, Peter A. Calabresi, Bruce Cree, Anne H. Cross, Mary F. Davis, Jonathan L. Haines, Paul I. W. de Bakker, Silvia Delgado, Marieme Dembele, Keith R. Edwards, Kathryn C. Fitzgerald, Hákon Hákonarson, Ioanna Konidari, Ellen Lathi, Clara P. Manrique, Margaret A. Pericak‐Vance, Laura Piccio, Cathy Schaefer, Cristin McCabe, Howard L. Weiner, Jacqueline I. Goldstein, Tomas Olsson, Georgios M. Hadjigeorgiou, Bruce Taylor, Lotti Tajouri, Jac Charlesworth, David R. Booth, Hanne F. Harbo, Adrian J. Ivinson, Stephen L. Hauser, Alastair Compston, Graeme J. Stewart, Frauke Zipp, Lisa F. Barcellos, Sergio E. Baranzini, Filippo Martinelli Boneschi, Sandra D’Alfonso, Andreas Ziegler, Annette Oturai, Jacob L. McCauley, Stephen Sawcer, Jorge R. Oksenberg, Philip L. De Jager, Ingrid Kockum, D Hafler, Chris Cotsapas,
Multiple sclerosis is a complex neurological disease, with ∼20% of risk heritability attributable to common genetic variants, including >230 identified by genome-wide association studies. Multiple strands of evidence suggest that much of the remaining heritability is also due to additive effects of common variants rather than epistasis between these variants or mutations exclusive to individual families. Here, we show in 68,379 cases and controls that up to 5% of this heritability is explained by ...
Tópico(s): vaccines and immunoinformatics approaches
2018 - Cell Press | Cell