Bruno L. Giordano, Michele Esposito, Giancarlo Valente, Elia Formisano,
Abstract Recognizing sounds implicates the cerebral transformation of input waveforms into semantic representations. Although past research identified the superior temporal gyrus (STG) as a crucial cortical region, the computational fingerprint of these cerebral transformations remains poorly characterized. Here, we exploit a model comparison framework and contrasted the ability of acoustic, semantic (continuous and categorical) and sound-to-event deep neural network representation models to predict ...
Tópico(s): Music and Audio Processing
2023 - Nature Portfolio | Nature Neuroscience
Maria Francesca Freda, Raffaele De Luca Picione, Giovanna Esposito, Giancarlo Ragozini, Italo Testa,
Abstract Despite the growing interest on the notion of academic engagement (AE) and its relevance for students’ success, a few valid and reliable instruments on AE have been developed. Moreover, most of the available measures consider AE as a student’s trait rather than a relational and situated dynamic process. This study presents the development and validation of a new instrument, the SInAPSi Academic Engagement Scale (SAES), which was developed within a project coordinated by the SInAPSi center ...
Tópico(s): Education, Achievement, and Giftedness
2021 - Springer Science+Business Media | Current Psychology
Xiaoming Jia, Lohith Madireddy, Stacy J. Caillier, Adam Santaniello, Federica Esposito, Gıancarlo Comı, Olaf Stüve, Yuan Zhou, Bruce Taylor, Trevor J. Kilpatrick, Filippo Martinelli Boneschi, Bruce Cree, Jorge R. Oksenberg, Stephen L. Hauser, Sergio E. Baranzini,
Primary progressive multiple sclerosis (PPMS) causes accumulation of neurological disability from disease onset without clinical attacks typical of relapsing multiple sclerosis (RMS). However, whether genetic variation influences the disease course remains unclear. We aimed to determine whether mutations causative of neurological disorders that share features with multiple sclerosis (MS) contribute to risk for developing PPMS.
Tópico(s): Cytokine Signaling Pathways and Interactions
2018 - Wiley | Annals of Neurology
Giuseppe Curigliano, Davide Disalvatore, Alessandro Esposito, Giancarlo Pruneri, Matteo Lazzeroni, Aliana Guerrieri‐Gonzaga, Alberto Luini, Roberto Orecchia, Aron Goldhirsch, Nicole Rotmensz, Bernardo Bonanni, Giuseppe Viale,
HER2 overexpression in primary ductal carcinomain situ (DCIS) was associated with a higher risk of in situ recurrence. No association with a higher risk of invasive breast cancer recurrence was observed. Our data have shown a clear benefit from radiotherapy in HER2-positive DCIS.BackgroundTo assess the prognostic role of human epidermal growth factor receptor 2 (HER2) overexpression in patients with ductal carcinomain situ (DCIS).Patients and methodsWe identified patients with HER2-positive DCIS among ...
Tópico(s): Cancer Treatment and Pharmacology
2015 - Elsevier BV | Annals of Oncology
Eleonora Palma, Davide Ragozzino, Silvia Di Angelantonio, Addolorata Mascia, Francesca Maiolino, M. Manfredi, Giampaolo Cantore, Vincenzo Esposito, Giancarlo Di Gennaro, P. P. Quarato, Ricardo Miledi, Fabrizio Eusebi,
Summary: Purpose: GABA A receptors from the brain of patients afflicted with mesial temporal lobe epilepsy (MTLE) become less efficient (run‐down) when repetitively activated by GABA. Experiments were designed to investigate whether the antiepileptic drug, levetiracetam (LEV), which is used as an adjunctive treatment for medically intractable MTLE, counteracts the GABA A receptor run‐down. Methods: GABA A receptors were microtransplanted from the brains of patients afflicted with MTLE into Xenopus ...
Tópico(s): Lipid Membrane Structure and Behavior
2007 - Wiley | Epilepsia
Liliana G. Grammaldo, T. Giampà, Pier Paolo Quarato, Angelo Picardi, Addolorata Mascia, A. Sparano, G Meldolesi, Fabio Sebastiano, Vincenzo Esposito, Giancarlo Di Gennaro,
Our aim was to test the lateralizing value of a neuropsychological battery including several memory tests on a large sample of consecutive patients with drug‐resistant temporal lobe epilepsy (TLE) evaluated for epilepsy surgery. We studied 73 right‐handed patients (56% males, mean age 35.3 ± 11.2 years, 49% left TLE) aged 16 years or older with normal IQ who underwent a preoperative neuropsychological assessment including several memory tests and were seizure‐free after at least 1 year of follow‐up. ...
Tópico(s): Neuroscience and Neuropharmacology Research
2006 - Wiley | European Journal of Neurology
Produção Nacional
Revisado por pares
Javier Bustamante Mamani, Lionel Fernel Gamarra, Giancarlo Espósito de Souza Brito,
Nowadays the use of magnetic nanoparticles (MNP) in medical applications has exceeded expectations. In molecular imaging, MNP based on iron oxide coated with appropriated materials have several applications in vitro and in vivo studies. For applications in nanobiotechnology these MNP must present some characteristics such as size smaller than 100 nanometers, high magnetization values, among others. Therefore the MNP have physical and chemical properties that are specific to certain studies which ...
Tópico(s): Iron oxide chemistry and applications
2014 - Associação Brasileira de Metalurgia e Materiais (ABM); Associação Brasileira de Cerâmica (ABC); Associação Brasileira de Polímer | Materials Research
Produção Nacional
Marcela Charantola Rodrigues, Thiago Lewis Reis Hewer, Giancarlo Espósito de Souza Brito, Victor E. Arana‐Chavez, Roberto Ruggiero Braga,
The synthesis of calcium phosphate nanoparticles may include modifying agents to tailor particle size, reduce agglomeration and add specific functionalities. This study describes the synthesis of dicalcium phosphate dihydrate (DCPD) nanoparticles functionalized with triethylene glycol dimethacrylate (TEGDMA), added to one of the reacting solutions, with the purpose of reducing agglomeration and improving the compatibility with vinyl-based resin matrices. The nanoparticles were characterized by X-ray ...
Tópico(s): Calcium Carbonate Crystallization and Inhibition
2014 - Elsevier BV | Materials Science and Engineering C
Produção Nacional
Revisado por pares
André Felipe Henriques Librantz, L. Gomes, S.L. Baldochi, I.M. Ranieri, Giancarlo Espósito de Souza Brito,
Tópico(s): Glass properties and applications
2006 - Elsevier BV | Journal of Luminescence
Produção Nacional
Revisado por pares
Giancarlo Espósito de Souza Brito, Celso V. Santilli, Sandra H. Pulcinelli,
The structural evolution during sintering of compacted SnO2 sol-gel powder was investigated using nitrogen adsorption isotherm analysis. Results show that for sintering temperatures up to 400°C the samples have a fractal pore size distribution. As the sintering temperature increases, a structural rearragement occurs, allowing an increase of the efficiency of particle packing and the reduction of fractality. Above 400°C, the pore size growth associated with grain coalescence is the main structural ...
Tópico(s): Granular flow and fluidized beds
1995 - Elsevier BV | Colloids and Surfaces A Physicochemical and Engineering Aspects
Gabriele Sciacca, Petra Martini, Sara Cisternino, Liliana Mou, Jonathan Amico, J. Esposito, Giancarlo Gorgoni, Emiliano Cazzola,
Cyclotron-based radionuclides production by using solid targets has become important in the last years due to the growing demand of radiometals, e.g.,
Tópico(s): Advanced Materials Characterization Techniques
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Sara Casciato, Angelo Picardi, Alfredo D’Aniello, Marco De Risi, Giovanni Grillea, Pier Paolo Quarato, Addolorata Mascia, Liliana G. Grammaldo, G Meldolesi, Roberta Morace, Vincenzo Esposito, Giancarlo Di Gennaro,
PurposeTo assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) detected by using 3 Tesla MRI in the preoperative workup in patients with temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS) who underwent surgery.MethodsWe studied 78 consecutive patients with TLE-HS who underwent surgery and were followed up for at least 2 years. Based on findings of pre-surgical 3 Tesla MRI, patients were subdivided in subgroups according ...
Tópico(s): Neuroscience and Neuropharmacology Research
2017 - Elsevier BV | Seizure
Giuseppe Curigliano, Carmen Criscitiello, Angela Espósito, Giancarlo Pruneri,
Avoidance of unnecessary or ineffective treatment should be one of the main goals in adjuvant breast oncology today. Unfortunately, both patients and doctors hunt for tiny statistical differences in survival curves. This search could not only lead to an oncological approach of unlimited addition that we will not be able to afford, but would also end inevitably in indeterminate overtreatment with substantial risks of unexpected toxic effects eating away whatever progress we might make. "Do not harm" ...
Tópico(s): Cancer Treatment and Pharmacology
2016 - Elsevier BV | The Breast
Sara Casciato, Carlo Di Bonaventura, Anna Teresa Giallonardo, Jinane Fattouch, Pier Paolo Quarato, Addolorata Mascia, Alfredo D’Aniello, Andrea Romigi, Vincenzo Esposito, Giancarlo Di Gennaro,
Tópico(s): Neuroscience and Neuropharmacology Research
2015 - Springer Science+Business Media | Neurosurgical Review
Giancarlo Esposito, S. Romano, Martien A. Hulsen, Gaetano D’Avino, Massimiliano M. Villone,
The dynamics of a cell suspended in a Newtonian liquid subjected to a pressure-driven flow at non-negligible inertia in cylindrical and square cross section microfluidic channels is studied through three-dimensional arbitrary Lagrangian–Eulerian finite-element numerical simulations. The cell is modeled through the neo-Hookean hyper-elastic constitutive equation, which can describe biological particles undergoing moderate deformations. The cell-to-channel relative dimension is fixed to 0.2, whereas ...
Tópico(s): Microfluidic and Capillary Electrophoresis Applications
2022 - American Institute of Physics | Physics of Fluids
Produção Nacional
Revisado por pares
J. Mantilla, V. Bindilatti, E. ter Haar, J. A. H. Coaquira, Giancarlo Espósito de Souza Brito, X. Gratens, V. Sagredo,
We present measurements of the magnetic and structural properties of the magnetic semiconductor MnIn2Se4 and Zn1−xMnxIn2Se4(x=0.87). The localized Mn ions in the layered rhombohedral structure undergo a spin-freezing transition below 3.5K. The frequency-dependent freezing temperature Tf varies as ΔTf/(TfΔlogω)≈0.022, indicating spin-glass behavior.
Tópico(s): Phase-change materials and chalcogenides
2004 - Elsevier BV | Journal of Magnetism and Magnetic Materials
Erica Butti, Alessandra Bergami, Alessandra Recchia, Elena Brambilla, Ubaldo Del Carro, Stefano Amadio, Alessandro Cattalini, Marianna Esposito, Anna Stornaiuolo, Gıancarlo Comı, Stefano Pluchino, Fulvio Mavilio, Gianvito Martino, Roberto Furlan,
Central nervous system (CNS) delivery of anti-inflammatory cytokines, such as interleukin 4 (IL4), holds promise as treatment for multiple sclerosis (MS). We have previously shown that short-term herpes simplex virus type 1-mediated IL4 gene therapy is able to inhibit experimental autoimmune encephalomyelitis (EAE), an animal model of MS, in mice and non-human primates. Here, we show that a single administration of an IL4-expressing helper-dependent adenoviral vector (HD-Ad) into the cerebrospinal fluid ( ...
Tópico(s): CAR-T cell therapy research
2008 - Springer Nature | Gene Therapy
Roberto Gasparini, Paolo Durando, Filippo Ansaldi, Laura Sticchi, Federica Banfi, Daniela Amicizia, Donatella Panatto, Susanna Esposito, Nicola Principi, Giancarlo Icardi, Pietro Crovari,
A study was carried out on 2,696 Italian children, aged 0–14 years. The goals were: (1) to define the age-related impact of acute respiratory infections (ARI), measured as the risk of attendance at the Paediatric Emergency Room, (2) to better define the importance and proportion of influenza and respiratory syncytial virus (RSV) infections and (3) to acquire deeper knowledge of the influenza strains circulating in infants and children. A standardised emergency unit attendance risk (EUAR) was calculated, ...
Tópico(s): Pneumonia and Respiratory Infections
2007 - Springer Science+Business Media | European Journal of Clinical Microbiology & Infectious Diseases
Christian Esposito, Vincenzo Moscato, Giancarlo Sperlì,
Social Networks represent a cornerstone of our daily life, where the so-called social reviewing systems (SRSs) play a key role in our daily lives and are used to access data typically in the form of reviews. Due to their importance, social networks must be trustworthy and secure, so that their shared information can be used by the people without any concerns, and must be protected against possible attacks and misuses. One of the most critical attacks against the reputation system is represented by ...
Tópico(s): Mobile Crowdsensing and Crowdsourcing
2021 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Systems Man and Cybernetics Systems
Rocco Di Girolamo, Christian Esposito, Vincenzo Moscato, Giancarlo Sperlì,
Current Online Social Networks represent a means for the continuous generation and distribution of information, which is slightly changed when moving from a user to another during the traversing of the network. Such an amount of information can overcome the capacity of a single user to manage it, so it would be useful to reduce it so that the user is able to have a summary of the information flowing the network. To this aim, it is of crucial importance to detect events within such an information ...
Tópico(s): Opinion Dynamics and Social Influence
2020 - Elsevier BV | Knowledge-Based Systems
Giovanni Docimo, Angelo Cangiano, Roberto Maria Romano, Marcello Filograna Pignatelli, Chiara Offi, Vanda Amoresano Paglionico, Marilena Galdiero, Giovanna Donnarumma, Vincenzo Nigro, Daniela Espósito, Mario Rotondi, Giancarlo Candela, Daniela Pasquali,
The human microbiota is an integral component in the maintenance of health and of the immune system. Microbiome-wide association studies have found numerous diseases associated to dysbiosis. Studies are needed to move beyond correlations and begin to address causation. Autoimmune thyroid diseases (ATD) are one of the most common organ-specific autoimmune disorders with an increasing prevalence, higher than 5% worldwide. Most frequent manifestations of ATD are Hashimoto’s thyroiditis and Graves’ disease. ...
Tópico(s): Digestive system and related health
2020 - Frontiers Media | Frontiers in Endocrinology
Fabiola Di Dato, Simona Spadarella, Maria Giovanna Puoti, Maria Grazia Caprio, Severo Pagliardini, Claudia Zuppaldi, Gianfranco Vallone, Simona Fecarotta, Gabriella Esposito, Raffaele Iorio, Giancarlo Parenti, Maria Immacolata Spagnuolo,
Background: Hereditary fructose intolerance (HFI) is a rare genetic disorder of fructose metabolism due to aldolase B enzyme deficiency. Treatment consists of fructose, sorbitol, and sucrose (FSS)-free diet. We explore possible correlations between daily fructose traces intake and liver injury biomarkers on a long-term period, in a cohort of young patients affected by HFI. Methods: Patients’ clinical data and fructose daily intake were retrospectively collected. Correlations among fructose intake, ...
Tópico(s): Diet and metabolism studies
2019 - Multidisciplinary Digital Publishing Institute | Nutrients
Raffaele Limosani, Raffele Esposito, Alessandro Manzi, Giancarlo Teti, Filippo Cavallo, Paolo Dario,
Robotic solutions for delivery tasks in urban and unstructured areas have represented a solid and considerable field of research in recent years. The aim of the proposed paper is to present the technical feasibility and usability of a robotic solution able to carry items from outdoor areas up to the user's apartment and vice-versa. The proposed solution is based on three heterogeneous mobile platforms, working in three different environments (domestic, condominium, outdoor), able to cooperate among ...
Tópico(s): Robotics and Automated Systems
2018 - Elsevier BV | Robotics and Autonomous Systems
Marzia Romeo, Filippo Martinelli Boneschi, M. Rodegher, Federica Esposito, Vittorio Martinelli, Gıancarlo Comı,
Background and purpose It is still unclear which patients benefit more from available disease‐modifying treatments ( DMT s) in multiple sclerosis ( MS ). Our objective is to identify the baseline clinical and magnetic resonance imaging ( MRI ) predictors of response to first‐line DMT s in a cohort of relapsing–remitting ( RR ) MS patients in a real‐world clinical setting. Methods Consecutive naïve RRMS patients treated with interferon‐beta or glatiramer acetate have been included and followed for 2 years. Patients ...
Tópico(s): Peripheral Neuropathies and Disorders
2013 - Wiley | European Journal of Neurology
Maria Rosaria D’Esposito, Francesco Palumbo, Giancarlo Ragozini,
Abstract Archetypal analysis aims at synthesizing single‐valued data sets through a few (not necessarily observed) points that are called archetypes, under the constraint that all points can be represented as a convex combination of the archetypes themselves and that the archetypes are a convex combination of the data. In this paper, we extend this methodology to the case of interval‐valued data, which represent a special case of set‐valued data, where the sets are compact and identified by ordered ...
Tópico(s): Neural Networks and Applications
2012 - Wiley | Statistical Analysis and Data Mining The ASA Data Science Journal
Giuliana Giardino, Anna Fusco, Rosa Romano, Vera Gallo, Francesca Maio, Tiziana Esposito, Loredana Palamaro, Giancarlo Parenti, Mariacarolina Salerno, Pietro Vajro, Claudio Pignata,
Ataxia telangiectasia (A-T) is a rare autosomal recessive disorder characterized by progressive neurological dysfunction. To date, only supportive care aimed to halt the progressive neurodegeneration is available for the treatment. Recently, an improvement of neurological signs during short-term treatment with betamethasone has been reported. To date, the molecular and biochemical mechanisms by which the steroid produces such effects have not yet been elucidated. Therefore, a review of the literature ...
Tópico(s): Carcinogens and Genotoxicity Assessment
2012 - Wiley | European Journal of Neurology
Valerio Cecinati, Susanna Esposito, Barbara Schicchitano, Giancarlo Vecchio, Doriana Amato, Claudio Pelucchi, Momcilo Jankovic, Domenico De Mattia, Nicola Principi,
In order to verify whether a telephone recall system directly managed by the pediatricians who usually follow up the children for their cancer, with influenza vaccine administered in the oncological clinic, is more effective than an anonymous recall system, 205 children with oncohematological malignancies were randomised to one of three intervention strategies for increasing influenza vaccination coverage. The results showed that all of the strategies were useful in increasing influenza vaccination ...
Tópico(s): Pneumonia and Respiratory Infections
2010 - Landes Bioscience | Human Vaccines
Gelsomina Mansueto, Floriana Forzati, Angelo Ferraro, Pierlorenzo Pallante, Maria Rosaria Bianco, Francesco Esposito, Antonino Iaccarino, Giancarlo Troncone, Alfredo Fusco,
High mobility group A (HMGA) overexpression plays a critical role in neoplastic transformation. To investigate whether HMGA acts by regulating the expression of microRNAs, we analyzed the microRNA expression profile of human breast adenocarcinoma cells (MCF7) transfected with the HMGA1 gene, which results in a highly malignant phenotype. Among the microRNAs induced by HMGA1, we focused on miR-181b, which was overexpressed in several malignant neoplasias including breast carcinomas. We show that miR- ...
Tópico(s): Circular RNAs in diseases
2010 - SAGE Publishing | Genes & Cancer
Daniele De Brasi, Teresa Esposito, Massimiliano Rossi, Giancarlo Parenti, MP Sperandeo, A Zuppaldi, Tiziana Bardaro, M.Amalia Ambruzzi, Leopoldo Zelante, Alfredo Ciccodicola, Gianfranco Sebastio, Michele D’Urso, Generoso Andria,
The Smith-Lemli-Opitz syndrome (SLOS) is an autosomal recessive disorder of cholesterol biosynthesis characterised by facial dysmorphisms, mental retardation and multiple congenital anomalies. SLOS is caused by mutations of the human Δ7-sterol reductase (DHCR7) gene and, so far, 19 different mutations have been described. Among these, mutations impairing the activity of the C-terminus appear to be the most severe. Here we report the mutational analysis of the DHCR7 gene in nine Italian SLOS patients. ...
Tópico(s): Peroxisome Proliferator-Activated Receptors
1999 - Springer Nature | European Journal of Human Genetics
Lorella Paparo, Serena Coppola, Rita Nocerino, Laura Pisapia, Gianluca Picariello, Maddalena Cortese, Luana Voto, Mariantonia Maglio, Erasmo Miele, Laura R. Carucci, Franca Oglio, Giovanna Trinchese, Maria Pina Mollica, Cristina Bruno, Simone De Vita, Antonietta Tarallo, Carla Damiano, Mariapina Cerulo, Ciro Esposito, Vincenzo Fogliano, Giancarlo Parenti, Riccardo Troncone, Roberto Berni Canani,
BackgroundFood allergy (FA) is one of the most common chronic conditions in children with an increasing prevalence facilitated by the exposure to environmental factors in predisposed individuals. It has been hypothesized that the increased consumption of ultra-processed foods, containing high levels of dietary advanced glycation end products (AGEs), could facilitate the occurrence of FA.ObjectiveWe sought to provide preclinical and clinical evidence on the potential role of AGEs in facilitating the ...
Tópico(s): Consumer Attitudes and Food Labeling
2023 - Elsevier BV | Journal of Allergy and Clinical Immunology