Adriano Chiò, Giuseppe Borghero, Andrea Calvo, Margherita Capasso, Claudia Caponnetto, Massimo Corbo, F. Giannini, Giancarlo Logroscino, Jessica Mandrioli, Norina Marcello, Letizia Mazzini, Cristina Moglia, Maria Rosaria Monsurrò, Gabriele Mora, Francesco Patti, Michele Perini, Vladimiro Pietrini, Fabrizio Pisano, Elisabetta Pupillo, Mario Sabatelli, Fabrizio Salvi, Vincenzo Silani, Isabella Laura Simone, Gianni Sorarù, M. R. Tola, Paolo Volanti, Ettore Beghi,
A neuroprotective effect of lithium in amyotrophic lateral sclerosis (ALS) has been recently reported. We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood levels (0.4-0.8 mEq/L, therapeutic group [TG], vs 0.2-0.4 mEq/L, subtherapeutic group [STG]).The study was a multicenter, single-blind, randomized, dose-finding trial, conducted from May 2008 to November 2009 in 21 Italian ALS centers. The ...
Tópico(s): Spinal Cord Injury Research
2010 - Lippincott Williams & Wilkins | Neurology
M. Varenna, L. Sinigaglia, S. Adámi, Sandro Giannini, Giancarlo Isaia, Stefania Maggi, Paolo Filipponi, Ombretta Di Munno, D. Maugeri, Daniela de Feo, Gaetano Crepaldi,
Tópico(s): Bone fractures and treatments
2005 - Springer Science+Business Media | Osteoporosis International
Carlo Diaferia, Teresa Sibillano, Davide Altamura, Valentina Roviello, Luigi Vitagliano, Cinzia Giannini, Giancarlo Morelli, Antonella Accardo,
Peptides containing aromatic residues are known to exhibit spontaneous phenomena of supramolecular organization into ordered nanostructures (NSs). In this work we studied the structural behavior and optoelectronic properties of new biocompatible materials obtained by the self-assembly of a series of hexaphenylalanines (F6) modified at the N terminus by a PEG chain of different lengths. PEG12 -F6, PEG18 -F6, and PEG24 -F6 peptides were synthesized by coupling sequentially two, three, or four units of ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2017 - Wiley | Chemistry - A European Journal
Carlo Diaferia, Moumita Ghosh, Teresa Sibillano, Enrico Gallo, Mariano Stornaiuolo, Cinzia Giannini, Giancarlo Morelli, Lihi Adler‐Abramovich, Antonella Accardo,
Short peptides or single amino acids are interesting building blocks for fabrication of hydrogels, frequently used as extracellular matrix-mimicking scaffolds for cell growth in tissue engineering.
Tópico(s): RNA Interference and Gene Delivery
2018 - Royal Society of Chemistry | Soft Matter
Carlo Diaferia, Nicole Balasco, Davide Altamura, Teresa Sibillano, Enrico Gallo, Valentina Roviello, Cinzia Giannini, Giancarlo Morelli, Luigi Vitagliano, Antonella Accardo,
All F6 variants (charged or uncharged peptides) self-assemble in amyloid-like structures of rich β-sheets.
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2018 - Royal Society of Chemistry | Soft Matter
Carlo Diaferia, Francesca Netti, Moumita Ghosh, Teresa Sibillano, Cinzia Giannini, Giancarlo Morelli, Lihi Adler‐Abramovich, Antonella Accardo,
Over the last few years, hydrogels have been proposed for many biomedical applications, including drug delivery systems and scaffolds for tissue engineering.
Tópico(s): Hydrogels: synthesis, properties, applications
2020 - Royal Society of Chemistry | Soft Matter
Elisabetta Rosa, Carlo Diaferia, Eliana Gianolio, Teresa Sibillano, Enrico Gallo, Giovanni Smaldone, Mariano Stornaiuolo, Cinzia Giannini, Giancarlo Morelli, Antonella Accardo,
In the last years, peptide-based hydrogels are being increasingly used as suitable matrices for biomedical and pharmaceutical applications, including drug delivery and tissue engineering. Recently, the synthesis and the gelation properties of a small library of cationic peptides, containing a Lys residue at the C-terminus and derivatized with an Fmoc group or with the fluorenyl methoxycarbonyl-diphenylalanine (FmocFF) at the N-terminus are derived. Here, it is demonstrated that the combination of ...
Tópico(s): RNA Interference and Gene Delivery
2022 - Wiley | Macromolecular Bioscience
Emilio Portaccio, Pietro Annovazzi, Angelo Ghezzi, Mauro Zaffaroni, Lucia Moiola, Vittorio Martinelli, Roberta Lanzillo, Vincenzo Brescia Morra, Francesca Rinaldi, Paolo Gallo, Carla Tortorella, Damiano Paolicelli, Carlo Pozzilli, Laura De Giglio, Paola Cavalla, Eleonora Cocco, Maria Giovanna Marrosu, Francesco Patti, Claudio Solaro, Paolo Bellantonio, Antonio Uccelli, Alice Laroni, Luisa Pastò, Marta Giannini, Maria Trojano, Gıancarlo Comı, Maria Pia Amato, Maria Pia Amato, Emilio Portaccio, Bahia Hakiki, Luisa Pastò, Marta Giannini, Lorenzo Razzolini, Isabella Righini, G. Siracusa, Angelo Ghezzi, Pietro Annovazzi, Mauro Zaffaroni, V. Martinelli, Marta Radaelli, Lucia Moiola, Gıancarlo Comı, Alessandra Protti, Emanuela Susani, R. Marazzi, Paolo Confalonieri, Valentina Torri Clerici, Paola Cavalla, Carlotta Chiavazza, Roberto Bergamaschi, Gianluigi Mancardi, Antonio Uccelli, Elisabetta Capello, Alice Laroni, Claudio Solaro, MR Tola, Luisa Caniatti, Franco Granella, Pasquale Annunziata, Katrin Plewnia, Leonello Guidi, ML Bartolozzi, Maria Rosa Mazzoni, Carlo Pozzilli, Laura De Giglio, Rocco Totaro, A Carolei, Maria Rita Rossi, Alessandra Lugaresi, Giovanna De Luca, V. Di Tommaso, Carla Tortorella, Damiano Paolicelli, Martina D’Onghia, Maria Trojano, Maria Giovanna Marrosu, Eleonora Cocco, Maurizio Melis, Francesco Patti, Cláudio Leone, Salvatore Lo Fermo, P. Bellantonio, Roberta Fantozzi, Claudio Gasperini, Alfonso Iudice, Antonio Bosco, Arianna Sartori, Roberta Lanzillo, Vincenzo Brescia Morra,
Objective To assess fetal risk after pregnancy exposure to natalizumab in women with multiple sclerosis (MS), with a specific focus on spontaneous abortion (SA) and congenital anomalies (CA). Methods Data of all pregnancies occurring between 2009 and 2015 in patients with MS treated with natalizumab and referring to 19 participating sites were collected and compared with those of pregnancies in untreated patients and patients treated with injectable immunomodulatory agents. Rates of SA and CA were also compared ...
Tópico(s): Polyomavirus and related diseases
2018 - Lippincott Williams & Wilkins | Neurology
Emilio Portaccio, Lucia Moiola, Vittorio Martinelli, Pietro Annovazzi, Angelo Ghezzi, Mauro Zaffaroni, Roberta Lanzillo, Vincenzo Brescia Morra, Francesca Rinaldi, Paolo Gallo, Carla Tortorella, Damiano Paolicelli, Carlo Pozzilli, Laura De Giglio, Paola Cavalla, Eleonora Cocco, Maria Giovanna Marrosu, Claudio Solaro, Antonio Uccelli, Alice Laroni, Luisa Pastò, Marta Giannini, Maria Trojano, Giancarlo Comi, Maria Pia Amato, Maria Pia Amato, Emilio Portaccio, Bahia Hakiki, Luisa Pastò, Marta Giannini, Lorenzo Razzolini, Isabella Righini, G. Siracusa, Angelo Ghezzi, Pietro Annovazzi, Mauro Zaffaroni, V. Martinelli, Marta Radaelli, Lucia Moiola, Giancarlo Comi, Alessandra Protti, Emanuela Susani, R. Marazzi, Paolo Confalonieri, Valentina Torri Clerici, Paola Cavalla, Carlotta Chiavazza, Roberto Bergamaschi, Gianluigi Mancardi, Antonio Uccelli, Elisabetta Capello, Alice Laroni, Claudio Solaro, MR Tola, Luisa Caniatti, Franco Granella, Pasquale Annunziata, Katrin Plewnia, Leonello Guidi, ML Bartolozzi, Maria Rosa Mazzoni, Carlo Pozzilli, Laura De Giglio, Rocco Totaro, A Carolei, Maria Rita Rossi, Alessandra Lugaresi, Giovanna De Luca, V. Di Tommaso, Carla Tortorella, Damiano Paolicelli, Martina D’Onghia, Maria Trojano, Maria Giovanna Marrosu, Eleonora Cocco, Maurizio Melis, Francesco Patti, Cláudio Leone, Salvatore Lo Fermo, P. Bellantonio, Roberta Fantozzi, Claudio Gasperini, Alfonso Iudice, Antonio Bosco, Arianna Sartori, Roberta Lanzillo, Vincenzo Brescia Morra,
Objective To assess the risk of disease reactivation during pregnancy after natalizumab suspension in women with multiple sclerosis (MS). Methods Data of all pregnancies occurring between 2009 and 2015 in patients with MS treated with natalizumab and referring to 19 participating sites were collected and compared with those of pregnancies in untreated patients and patients treated with injectable immunomodulatory agents through a 2-factor repeated measures analysis. Predictors of disease activity were assessed ...
Tópico(s): Pregnancy and Medication Impact
2018 - Lippincott Williams & Wilkins | Neurology
Silvano Adami, Sandro Giannini, R. Giorgino, Giancarlo Isaia, Stefania Maggi, L. Sinigaglia, Paolo Filipponi, Gaetano Crepaldi, Ombretta Di Munno,
Tópico(s): Body Composition Measurement Techniques
2003 - Springer Science+Business Media | Osteoporosis International
Carlo Diaferia, Flavia Anna Mercurio, Cinzia Giannini, Teresa Sibillano, Giancarlo Morelli, Marilisa Leone, Antonella Accardo,
Abstract Water soluble fibers of PEGylated tetra-phenylalanine (F4), chemically modified at the N-terminus with the DOTA chelating agent, have been proposed as innovative contrast agent (CA) in Magnetic Resonance Imaging (MRI) upon complexation of the gadolinium ion. An in-depth structural characterization of PEGylated F4-fibers, in presence (DOTA-L 6 -F4) and in absence of DOTA (L 6 -F4), is reported in solution and at the solid state, by a multiplicity of techniques including CD, FTIR, NMR, DLS, WAXS ...
Tópico(s): Metal-Organic Frameworks: Synthesis and Applications
2016 - Nature Portfolio | Scientific Reports
Sara La Manna, Valentina Roviello, Pasqualina Liana Scognamiglio, Carlo Diaferia, Cinzia Giannini, Teresa Sibillano, Giancarlo Morelli, Ettore Novellino, Daniela Marasco,
Nucleophosmin (NPM1) is the most frequently mutated gene in Acute Myeloid Leukemia (AML) patients and mutations lead to its aberrant cytoplasmatic accumulation in leukemic cells. Its C-terminal domain (CTD) is endowed with a globular structure consisting of a three-helix bundle in the wild type form that is disrupted by AML mutations. Our recent results demonstrate, unexpectedly and unequivocally, that regions of the CTD of NPM1 are prone to aggregate to amyloid states. Here we present novel studies, ...
Tópico(s): Nuclear Structure and Function
2018 - Elsevier BV | International Journal of Biological Macromolecules
Carlo Diaferia, Nicole Balasco, Teresa Sibillano, Cinzia Giannini, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo,
Over the years, a large number of multidisciplinary investigations has unveiled that the self-assembly of short peptides and even of individual amino acids can generate a variety of different biomaterials. In this framework, we have recently reported that polyethylene glycol (PEG) conjugates of short homopeptides, containing aromatic amino acids such as phenylalanine (Phe, F) and naphthylalanine (Nal), are able to form elongated fibrillary aggregates having interesting chemical and physical properties. ...
Tópico(s): Luminescence and Fluorescent Materials
2018 - Wiley | ChemPhysChem
Carlo Diaferia, Nicole Balasco, Teresa Sibillano, Moumita Ghosh, Lihi Adler‐Abramovich, Cinzia Giannini, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo,
Phenylalanine-based nanostructures have attracted the attention of the material science community for their functional properties. These properties strongly depend on the hierarchic organization of the nanostructure that in turn can be finely tuned by punctual chemical modifications of the building blocks. Herein, we investigate how the partial or the complete replacement of the Phe residues in PEG8 -(Phe)6 (PEG8 -F6) with tyrosines to generate PEG8 -(Phe-Tyr)3 (PEG8 -(FY)3) or PEG8 -(Tyr)6 (PEG8 -Y6) affects ...
Tópico(s): Enzyme Structure and Function
2018 - Wiley | Chemistry - A European Journal
Nicole Balasco, Davide Altamura, Pasqualina Liana Scognamiglio, Teresa Sibillano, Cinzia Giannini, Giancarlo Morelli, Luigi Vitagliano, Antonella Accardo, Carlo Diaferia,
Peptides are able to self-organize in structural elements including cross-β structures. Taking advantage of this tendency, in the last decades, peptides have been scrutinized as molecular elements for the development of multivalent supramolecular architectures. In this context, different classes of peptides, also with completely aromatic sequences, were proposed. Our previous studies highlighted that the (FY)3 peptide, which alternates hydrophobic phenylalanine and more hydrophilic tyrosine residues, ...
Tópico(s): Luminescence and Fluorescent Materials
2024 - American Chemical Society | Langmuir
Enrico Gallo, Carlo Diaferia, Nicole Balasco, Teresa Sibillano, Valentina Roviello, Cinzia Giannini, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo,
Abstract Aromatic polypeptides have recently drawn the interest of the research community for their capability to self-assemble into a variety of functional nanostructures. Due to their interesting mechanical, electrical and optical properties, these nanostructures have been proposed as innovative materials in different biomedical, biotechnological and industrial fields. Recently, several efforts have been employed in the development of these innovative materials as nanoscale fluorescence (FL) imaging ...
Tópico(s): Luminescence and Fluorescent Materials
2021 - Nature Portfolio | Scientific Reports
Stefania Maggi, Marianna Noale, Sandro Giannini, S. Adámi, D. Defeo, Giancarlo Isaia, L. Sinigaglia, Paolo Filipponi, Gaetano Crepaldi,
Tópico(s): Bone fractures and treatments
2005 - Springer Science+Business Media | Osteoporosis International
Francesco Panza, Vincenzo Solfrizzi, Michele Giannini, Davide Seripa, Alberto Pilotto, Giancarlo Logroscino,
OPINION article Front. Aging Neurosci., 26 August 2014Sec. Neurocognitive Aging and Behavior Volume 6 - 2014 | https://doi.org/10.3389/fnagi.2014.00221
Tópico(s): Dementia and Cognitive Impairment Research
2014 - Frontiers Media | Frontiers in Aging Neuroscience
Francesco Panza, Vincenzo Solfrizzi, Bruno P. Imbimbo, Michele Giannini, Andrea Santamato, Davide Seripa, Giancarlo Logroscino,
Among active and passive anti-β-amyloid (Aβ) immunotherapies for Alzheimer's disease (AD), bapineuzumab and solanezumab, two humanized monoclonal antibodies, failed to show significant clinical benefits in mild-to-moderate AD patients in large Phase III clinical trials. Another ongoing Phase III trial of solanezumab aims to confirm positive findings in mild AD patients. Gantenerumab is the first fully human anti-Aβ monoclonal antibody directed to both N-terminal and central regions of Aβ. A 6-month ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2014 - Taylor & Francis | Expert Review of Neurotherapeutics
Carlo Diaferia, Teresa Sibillano, Nicole Balasco, Cinzia Giannini, Valentina Roviello, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo,
Despite the growing literature about diphenylalanine-based peptide materials, it still remains a challenge to delineate the theoretical insight into peptide nanostructure formation and the structural features that could permit materials with enhanced properties to be engineered. Herein, we report the synthesis of a novel peptide building block composed of six phenylalanine residues and eight PEG units, PEG8 -F6. This aromatic peptide self-assembles in water in stable and well-ordered nanostructures ...
Tópico(s): Antimicrobial Peptides and Activities
2016 - Wiley | Chemistry - A European Journal
Anna Russo, Carlo Diaferia, Sara La Manna, Cinzia Giannini, Teresa Sibillano, Antonella Accardo, Giancarlo Morelli, Ettore Novellino, Daniela Marasco,
Nucleophosmin (NPM1) is a multifunctional protein involved in a variety of biological processes including the pathogenesis of several human malignancies and is the most frequently mutated gene in Acute Myeloid Leukemia (AML). To deepen the role of protein regions in its biological activities, lately we reported on the structural behavior of dissected C-terminal domain (CTD) helical fragments. Unexpectedly the H2 (residues 264–277) and H3 AML-mutated regions showed a remarkable tendency to form amyloid- ...
Tópico(s): Nuclear Structure and Function
2016 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics
Carlo Diaferia, Teresa Sibillano, Cinzia Giannini, Valentina Roviello, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo,
Abstract A great interest has been recently generated by the discovery that peptide‐based nanostructures (NSs) endowed with cross‐β structure may show interesting photoluminescent (PL) properties. It was shown that NSs formed by PEGylated hexaphenylalanine (PEG 8 ‐F6, PEG=polyethylene glycol) are able to emit at 460 nm when excited at 370 or 410 nm. Here, the possibility to transfer the fluorescence of these PEG 8 ‐F6‐based NSs by foster resonance electron transfer (FRET) phenomenon to a fluorescent dye ...
Tópico(s): Luminescence and Fluorescent Materials
2017 - Wiley | Chemistry - A European Journal
Carlo Diaferia, Eliana Gianolio, Teresa Sibillano, Flavia Anna Mercurio, Marilisa Leone, Cinzia Giannini, Nicole Balasco, Luigi Vitagliano, Giancarlo Morelli, Antonella Accardo,
Very recently we proposed novel di- and tetra-phenylalanine peptides derivatized with gadolinium complexes as potentials supramolecular diagnostic agents for applications in MRI (Magnetic Resonance Imaging). It was observed that in very short FF dipeptide building blocks, the propensity to aggregate decreases significantly after modification with bulky moiety such as Gd-complexes, thus limiting their potential as CAs. We hypothesized that the replacement of the Phe side chain with more extended aromatic ...
Tópico(s): Crystallography and molecular interactions
2017 - Nature Portfolio | Scientific Reports
Ettore Beghi, Elisabetta Pupillo, V. Bonito, P.J. Buzzi, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Fabio Giannini, Maurizio Inghilleri, Vincenzo La Bella, Giancarlo Logroscino, Lorenzo Lorusso, Christian Lunetta, Letizia Mazzini, Paolo Messina, Gabriele Mora, Michele Perini, Maria Lidia Quadrelli, Vincenzo Silani, Isabella Laura Simone, Lucio Tremolizzo,
Our objective was to assess the effects of acetyl-L-carnitine (ALC) with riluzole on disability and mortality of amyotrophic lateral sclerosis (ALS). Definite/probable ALS patients, 40−70 years of age, duration 6−24 months, self-sufficient (i.e. able to swallow, cut food/handle utensils, and walk), and with forced vital capacity (FVC) > 80% entered a pilot double-blind, placebo-controlled, parallel group trial and were followed for 48 weeks. ALC or placebo 3 g/day was added to riluzole 100 mg/day. Primary ...
Tópico(s): Parkinson's Disease Mechanisms and Treatments
2013 - Taylor & Francis | Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Giuseppe Lauria, Eleonora Dalla Bella, Giovanni Antonini, Giuseppe Borghero, Margherita Capasso, Claudia Caponnetto, Adriano Chiò, Massimo Corbo, Roberto Eleopra, Raffaella Fazio, Massimiliano Filosto, Fabio Giannini, Enrico Granieri, Vincenzo La Bella, Giancarlo Logroscino, Jessica Mandrioli, Letizia Mazzini, Maria Rosaria Monsurrò, Gabriele Mora, Vladimiro Pietrini, R. Quatrale, Romana Rizzi, Fabrizio Salvi, Gabriele Siciliano, Gianni Sorarù, Paolo Volanti, Irene Tramacere, Graziella Filippini,
To assess the efficacy of recombinant human erythropoietin (rhEPO) in amyotrophic lateral sclerosis (ALS).Patients with probable laboratory-supported, probable or definite ALS were enrolled by 25 Italian centres and randomly assigned (1:1) to receive intravenous rhEPO 40,000 IU or placebo fortnightly as add-on treatment to riluzole 100 mg daily for 12 months. The primary composite outcome was survival, tracheotomy or >23 h non-invasive ventilation (NIV). Secondary outcomes were ALSFRS-R, slow vital capacity ( ...
Tópico(s): Amyotrophic Lateral Sclerosis Research
2015 - BMJ | Journal of Neurology Neurosurgery & Psychiatry
Alberto Leardini, Aurelio Cappozzo, Fabio Catani, Søren Toksvig‐Larsen, Aldo Petitto, Vincenzo Sforza, Giancarlo Cassanelli, Sandro Giannini,
The present study assesses the accuracy with which the subject specific coordinates of the hip joint centre (HJC) in a pelvic anatomical frame can be estimated using different methods. The functional method was applied by calculating the centre of the best sphere described by the trajectory of markers placed on the thigh during several trials of hip rotations. Different prediction methods, proposed in the literature and in the present investigation, which estimate the HJC of adult subjects using ...
Tópico(s): Shoulder Injury and Treatment
1999 - Elsevier BV | Journal of Biomechanics
Francesca Belardinilli, Carlo Capalbo, Umberto Malapelle, Pasquale Pisapia, Domenico Raimondo, Edoardo Milanetti, Yasaman Mahdavian, Carlotta Liccardi, Paola Paci, Pasquale Sibilio, Francesco Pepe, Caterina Bonfiglio, Silvia Mezi, Valentina Magri, Anna Coppa, Arianna Nicolussi, Angela Gradilone, Marialaura Petroni, Stefano Di Giulio, Francesca Fabretti, Paola Infante, Sonia Coni, Gianluca Canettieri, Giancarlo Troncone, Giuseppe Giannini,
Extensive molecular characterization of human colorectal cancer (CRC) via Next Generation Sequencing (NGS) indicated that genetic or epigenetic dysregulation of a relevant, but limited, number of molecular pathways typically occurs in this tumor. The molecular picture of the disease is significantly complicated by the frequent occurrence of individually rare genetic aberrations, which expand tumor heterogeneity. Inter- and intratumor molecular heterogeneity is very likely responsible for the remarkable ...
Tópico(s): Cancer Genomics and Diagnostics
2020 - Frontiers Media | Frontiers in Oncology
Carlo Diaferia, Elisabetta Rosa, Nicole Balasco, Teresa Sibillano, Giancarlo Morelli, Cinzia Giannini, Luigi Vitagliano, Antonella Accardo,
Peptide-based hydrogels, originated by multiscale self-assembling phenomenon, have been proposed as multivalent tools in different technological areas. Structural studies and molecular dynamics simulations pointed out the capability of completely aromatic peptides to gelificate if hydrophilic and hydrophobic forces are opportunely balanced. Here, the effect produced by the introduction of a Cys residue in the heteroaromatic sequence of (FY)3 and in its PEGylated variant was evaluated. The physicochemical ...
Tópico(s): Bone and Dental Protein Studies
2021 - Wiley | Chemistry - A European Journal
Raffaele Giannini, Enrico Petazzoni, Giancarlo Savorani, Livia Galletti, Fabio Piscaglia, Federico Licastro, Luigi Bolondi, Domenico Cucinotta,
This study evaluated various outcomes of home care in a group of 121 chronically ill and frail elderly subjects followed for 24 months, starting from September 2001. The scheduled times of follow up were baseline, 6, 12, and 24 months. Subjects of both sexes were assigned to one of two groups. Control group (CG) (60 subjects: mean age 85.4 years, home care provided by the Social Health Service of the Emilia Romagna Region) and Intervention group (IG) (61 subjects, mean age 82.0 years), for whom the ...
Tópico(s): Dementia and Cognitive Impairment Research
2006 - Elsevier BV | Archives of Gerontology and Geriatrics
Xiaofei Xiao, Raymond Gillibert, Antonino Foti, Pierre‐Eugène Coulon, C. Ulysse, T. Levato, Stefan A. Maier, Vincenzo Giannini, P. G. Gucciardi, Giancarlo Rizza,
Surface-enhanced Raman optical activity (SEROA) has been extensively investigated due to its ability to directly probe stereochemistry and molecular structure. However, most works have focused on the Raman optical activity (ROA) effect arising from the chirality of the molecules on isotropic surfaces. Here, we propose a strategy for achieving a similar effect: i.e., a surface-enhanced Raman polarization rotation effect arising from the coupling of optically inactive molecules with the chiral plasmonic ...
Tópico(s): Spectroscopy Techniques in Biomedical and Chemical Research
2023 - American Chemical Society | Nano Letters