Leónidas Ntziachristos, Giannis Papadimitriou, N.E. Ligterink, Stefan Hausberger,
Diesel NOx emissions have been at the forefront of research and regulation scrutiny as a result of failures of late vehicle technologies to deliver on-road emissions reductions. The current study aims at identifying the actual emissions levels of late light duty vehicle technologies, including Euro 5 and Euro 6 ones. Mean NOx emission factor levels used in the most popular EU vehicle emission models (COPERT, HBEFA and VERSIT+) are compared with latest emission information collected in the laboratory ...
Tópico(s): Transportation Planning and Optimization
2016 - Elsevier BV | Atmospheric Environment
Dimitra Lekaki, Matina Kastori, Giannis Papadimitriou, Giorgos Mellios, Diego Guizzardi, Marilena Muntean, Monica Crippa, Gabriel Oreggioni, Leónidas Ntziachristos,
Road transport on one hand plays an important role in the world economy and significantly contributes to the global gross domestic product; on the other hand, it is one of the main sources of air pollution and greenhouse gas emissions, mostly originating from the consumption of liquid fossil fuels. One of the main tools to monitor emissions, in an effort to reduce them, is to maintain inventories where emissions are estimated on a regular basis. Many countries maintain their own inventories, while ...
Tópico(s): Air Quality and Health Impacts
2024 - Elsevier BV | Atmospheric Environment
Marios Papadimitriou, Giannis Mountzios, Christos Papadimitriou,
Abstract Triple-negative breast cancer (TNBC) accounts for approximately 15–20% of all breast cancers and is characterized by a lack of immunohistochemical expression of estrogen receptors (ER), progesterone receptors (PR) and HER2. TNBC is associated with poor long-term outcomes compared with other breast cancer subtypes. Many of these tumors are also basal-like cancers which are characterized by an aggressive biological behavior with a distant recurrence peak observed early at 3 years following diagnosis. ...
Tópico(s): Plant Genetic and Mutation Studies
2018 - Elsevier BV | Cancer Treatment Reviews
Helena Linardou, Evangelos Briasoulis, Issa J Dahabreh, Giannis Mountzios, Christos Papadimitriou, Savvas Papadopoulos, Dimitrios Bafaloukos, P. Kosmidis, Samuel Murray,
The KRAS oncogene has been extensively studied for more than three decades, however, it is only recently that it attained a central role in the clinical decision-making process for the practicing oncologist. Recently, based on retrospective analyses of large randomized clinical trials, the use of anti-epidermal growth factor (EGFR) monoclonal antibodies, cetuximab and panitumumab, was restricted to patients with metastatic colorectal cancer that carry the "wild-type"KRAS genotype. Challenges remain ...
Tópico(s): Lung Cancer Treatments and Mutations
2010 - Elsevier BV | Cancer Treatment Reviews
Maria Protopapa, Vassilis Kouloulias, Styliani Nikoloudi, Christos Papadimitriou, Giannis Gogalis, Anna Zygogianni,
Non-small cell lung cancer patients with brain metastases have a multitude of treatment options, but there is currently no international and multidisciplinary consensus concerning their optimal treatment. Local therapies have the principal role, especially in symptomatic patients. Advances in surgery and radiation therapy manage considerable local control. Systemic treatments have shown effect in clinical trials and in real life clinical settings; yet, at present, this is restricted to patients ...
Tópico(s): Lung Cancer Treatments and Mutations
2019 - Hindawi Publishing Corporation | Journal of Oncology
Giannis Mountzios, Meletios Α. Dimopoulos, Christos Papadimitriou,
Although platinum-based chemotherapy remains the “standard” in advanced non small-cell lung cancer, not all patients derive clinical benefit from such a treatment. Hence, the development of predictive biomarkers able to identify lung cancer patients who are most likely to benefit from cisplatin-based chemotherapy has become a scientific priority. Among the molecular pathways involved in DNA damage control after chemotherapy, the nucleotide excision repair (NER) is a critical process for the repair ...
Tópico(s): Genetic factors in colorectal cancer
2008 - SAGE Publishing | Biomarker Insights
Giannis Mountzios, Evangelos Terpos, Konstantinos Syrigos, Christos Papadimitriou, Giorgos N. Papadopoulos, Aristotelis Bamias, Myron Mavrikakis, Meletios Α. Dimopoulos,
The molecular triad, which includes the receptor activator of nuclear factor kappa-B ligand (RANKL), its receptor RANK, and the endogenous soluble RANKL decoy receptor osteoprotegerin (OPG), has emerged as an important determinant of bone metabolism. We aimed to evaluate the effect of treatment with the biphosphonate zoledronic acid (ZA) on biochemical markers of bone remodeling and to detect possible correlations of markerlevel changes with skeletal morbidity and clinical outcomes in patients with ...
Tópico(s): Bone health and osteoporosis research
2010 - Elsevier BV | Translational research
Panagiotis E. Antoniou, Kartsidis Panagiotis, Stefanos Xefteris, Arfaras Giorgos, Bamidis Panagiotis,
... ESMC workshop and undergraduate students Nikos Staikoglou and Giannis Papadimitriou for organizing and facilitating the pilot experimentation References [ ...
Tópico(s): Clinical Reasoning and Diagnostic Skills
2016 - Frontiers Media | Frontiers in Human Neuroscience
Giannis Mountzios, Meletios Α. Dimopoulos, Jean‐Charles Soria, Despina Sanoudou, Christos Papadimitriou,
Lung carcinogenesis is considered to be the result of composite environmental, genetic and epigenetic changes. Despite the fact that many of the genetic alterations, including loss of heterozygocity in the 3p chromosome locus and point mutations in the tumor-suppressor genes TP53 and retinoblastoma (RB1), occur in nearly all histopathologic types of lung cancer, the frequency and the "timing" of their occurrence seems to differ between small-cell lung cancer (SCLC) cells, that are characterized by ...
Tópico(s): Cancer therapeutics and mechanisms
2009 - Elsevier BV | Critical Reviews in Oncology/Hematology
Giannis Mountzios, Aspasia Soultati, Dimitrios Pectasides, Eirini Pectasides, Meletios Α. Dimopoulos, Christos Papadimitriou,
Despite the available prevention and early detection strategies, advanced squamous-cell carcinoma of the uterine cervix remains a major concern for public health. Systemic treatment with cisplatin, either in combination with external beam irradiation for locally advanced disease, or as monotherapy for recurrent/metastatic disease has been the cornerstone of treatment for more than two decades. Cisplatin has been also combined with a number of agents including paclitaxel, topotecan, gemcitabine, ...
Tópico(s): Cervical Cancer and HPV Research
2012 - Elsevier BV | Cancer Treatment Reviews
Aspasia Soultati, Giannis Mountzios, Chrysoula Avgerinou, George Papaxoinis, Dimitrios Pectasides, Meletios Α. Dimopoulos, Christos Papadimitriou,
In cancer biology angiogenesis plays a vital role in tumour growth and its subsequent metastatic potential. By targeting the angiogenic process, a new treatment strategy was added in the clinician's therapeutic armamentarium. On the other hand, numerous classic cytotoxic agents are currently considered as potential angiogenesis inhibitors, although they were not originally developed as such, representing the so-called "accidental" anti-angiogenic drugs. The discovery of these new properties of classic ...
Tópico(s): Cancer Treatment and Pharmacology
2011 - Elsevier BV | Cancer Treatment Reviews
Giannis Mountzios, Aspasia Soultati, Dimitrios Pectasides, Meletios Α. Dimopoulos, Christos Papadimitriou,
Despite the available prevention and early detection strategies, squamous-cell carcinoma of the uterine cervix is still diagnosed as locally advanced disease in a considerable proportion of patients. As a potent sensitizer of cancer cells, cisplatin has been the "traditional partner" of external beam irradiation in this setting for more than two decades. Induction chemotherapy strategies followed by concurrent chemoradiation or surgery and preoperative concurrent chemoradiation have been recently ...
Tópico(s): Cancer Risks and Factors
2013 - Hindawi Publishing Corporation | Obstetrics and Gynecology International
Samuel Murray, Helena Linardou, Giannis Mountzios, Menelaos Manoloukos, S. Markaki, Evangelos Eleutherakis‐Papaiakovou, Meletios Α. Dimopoulos, Christos Papadimitriou,
The rarity of uterine sarcomas along with their pathological and molecular heterogeneities render their study particularly challenging. We evaluated a panel of somatic mutations principally centering on the tyrosine kinase gene family and their downstream signaling cascades in an attempt to identify potential candidate markers that may assist in diagnostic or therapeutic decisions in these tumors.We performed mutational analysis of 20 exons from 9 genes (EGFR, CDKN2A, MET, KIT, RAS, BRAF, PI3KCA, ...
Tópico(s): Beetle Biology and Toxicology Studies
2010 - Elsevier BV | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Giannis Mountzios, Dimitrios Pectasides, Evangelos Bournakis, Eirini Pectasides, George Bozas, Meletios Α. Dimopoulos, Christos Papadimitriou,
Systemic treatment represents the cornerstone of endometrial cancer management in advanced, relapsed and metastatic disease, which is still characterized by poor prognosis. Progestins remain an effective option for patients with low grade, estrogen and/or progesterone receptor positive disease, with some of them achieving prolonged survival. Platinum compounds, anthracyclines and more recently taxanes have been implemented in combination regimens achieving response rates more than 50% and resulting ...
Tópico(s): Estrogen and related hormone effects
2010 - Elsevier BV | Critical Reviews in Oncology/Hematology
Giannis Mountzios, Meletios Α. Dimopoulos, Aristotelis Bamias, Georgia Vourli, Haralabos P. Kalofonos, Gerasimos Aravantinos, George Fountzilas, C.A. Papadimitriou,
BackgroundWe undertook a randomized phase II trial to test whether the addition of paclitaxel (Taxol) to the cisplatin and ifosfamide (IP) combination could improve objective response (OR) rate, progression-free survival (PFS) and overall survival (OS) in patients with recurrent or metastatic cancer of the uterine cervix.Patients and methodsOne hundred and fifty-three patients were randomly allocated to receive either the IP regimen (ifosfamide 1.5 g/m2, daily, on days 1–3 and cisplatin 70 mg/m2 on day ...
Tópico(s): Intraperitoneal and Appendiceal Malignancies
2009 - Elsevier BV | Annals of Oncology
Maria Vassilakopoulou, Giannis Mountzios, C. Papamechael, Athanase D. Protogerou, K. Aznaouridis, Paraskevi Katsichti, Kyriaki Venetsanou, Meletios Α. Dimopoulos, Ignatios Ikonomidis, Christos Papadimitriou,
Antitumor activity of paclitaxel is based on promotion of abnormal microtubule (MT) assembly but it is also considered to have significant pro-inflammatory and anti-angiogenic effects in vivo and thus may cause vascular dysfunction. We studied 27 women treated with paclitaxel-containing combinations for breast or ovarian cancer. The control group was represented by 10 women with carcinoma of the uterine cervix who received low doses of weekly cisplatin as radiation sensitizer. We measured endothelial- ...
Tópico(s): Angiogenesis and VEGF in Cancer
2010 - Elsevier BV | Vascular Pharmacology
Grammati-Eirini Kastori, Giannis Papadimitriou, Petros Katsis, Chariton Kouridis, Georgios K. D. Saharidis,
Tópico(s): Atmospheric chemistry and aerosols
2019 - Springer Science+Business Media | Energy Systems
Christos Makris, Andreas Papadimitriou, Vasilis Baltikas, Giannis Spiliopoulos, Yiannis Kontos, Anastasios S. Metallinos, Yannis Androulidakis, Michalis Chondros, Georgios Klonaris, Dimitra I. Malliouri, Nikolaos Nagkoulis, Dimitris Zissis, Vasiliki K. Tsoukala, Theophanis V. Karambas, Constantine D. Memos,
This paper presents a recently developed Operational Forecast Platform (OFP) for prevailing sea conditions at very important ports worldwide (Accu-Waves). The OFP produces reliable high-resolution predictions of wave characteristics in and around ocean ports. Its goal is to support safer navigation, predict possible port downtime, assist vessel approaching, enhance management of towing services, and bolster secure ship maneuvering in busy ports around the globe. Accu-Waves OFP is based on integrated, ...
Tópico(s): Oceanographic and Atmospheric Processes
2024 - Multidisciplinary Digital Publishing Institute | Journal of Marine Science and Engineering
Giannis Mountzios, A. Bamias, D. Papadimitriou, E. Pissakas, George Bozas, G. Lainakis, Evangelos Lianos, Efstathios Kastritis, Meletios Α. Dimopoulos,
To evaluate the applicability of carbon ion beams for the treatment of carcinoma of the lacrimal gland with regard to normal tissue morbidity and local tumor control.Between April 2002 and January 2011, 21 patients with locally advanced primary epithelial carcinoma of the lacrimal gland were enrolled in a Phase I/II clinical trial of carbon-ion radiotherapy (CIRT) at the National Institute of Radiological Sciences. Acute radiation toxicity was the primary endpoint of this dose-escalation study and ...
Tópico(s): Nasolacrimal Duct Obstruction Treatments
2007 - Elsevier BV | European Journal of Cancer Supplements
Yong Zhao, Brian Lin, Michael Dingeldein, Chengshan Guo, David Hwang, Mark Holterman, Wolfgang M. Kuebler, Todd C. Rideout, Scott Harding, Christopher P. F. Marinangeli, Peter Jones, Aishan Bilali, Shun‐ichi Kurata, Satoshi Ikeda, Gabriela Georgieva, Chenting Zhu, Makoto Tomita, Iyoko Katoh, Chieko Mitaka, Yoshinobu Eishi, Takasuke Imai, Nikolaos P.E. Kadoglou, Stilianos Lampropoulos, Alkistis Kapelouzou, Argirios Gkontopoulos, Efstratios Theofi Logiannakos, Grigorios Fotiadis, George Kottas, Giannis Mountzios, Evangelos Terpos, Konstantinos Syrigos, Christos Papadimitriou, Giorgos N. Papadopoulos, Aristotelis Bamias, Myron Mavrikakis, Meletios Α. Dimopoulos, Greece Athens, Marija Matić, Tatjana Simić, Dejan Dragičević, Jasmina Mimić-Oka, Marija Plješa-Ercegovac, Ana Savić-Radojevic,
2010 - Elsevier BV | Translational research
Yong Zhao, Brian Lin, Michael Dingeldein, Chengshan Guo, David Hwang, Mark Holterman, Wolfgang M. Kuebler, Todd C. Rideout, Scott Harding, Christopher P. F. Marinangeli, Peter Jones, Aishan Bilali, Shun‐ichi Kurata, Satoshi Ikeda, Gabriela Georgieva, Chenting Zhu, Makoto Tomita, Iyoko Katoh, Chieko Mitaka, Yoshinobu Eishi, Takasuke Imai, Nikolaos P.E. Kadoglou, Stilianos Lampropoulos, Alkistis Kapelouzou, Argirios Gkontopoulos, Efstratios Theofi Logiannakos, Grigorios Fotiadis, George Kottas, Giannis Mountzios, Evangelos Terpos, Konstantinos Syrigos, Christos Papadimitriou, Giorgos N. Papadopoulos, Aristotelis Bamias, Myron Mavrikakis, Meletios Α. Dimopoulos, Greece Athens, Marija Matić, Tatjana Simić, Dejan Dragičević, Jasmina Mimić-Oka, Marija Plješa-Ercegovac, Ana Savić-Radojevic,
2010 - Elsevier BV | Translational research
Giannis Mountzios, Meletios Α. Dimopoulos, A. Bamias, Georgia Vourli, Haralabos P. Kalofonos, Gerasimos Aravantinos, George Fountzilas, C. Papadimitriou,
To assess the efficacy and toxicity profile in patients with recurrent ovarian or primary peritoneal cancer treated with topotecan at 2.5 mg/m2 days 1 and 8 plus vinorelbine at 25 mg/m2 days 1 and 8 every 3 weeks.Eligibility criteria included patients with recurrent primary peritoneal or epithelial ovarian cancer with either platinum-resistant or platinum-sensitive disease. Patients were required to have a performance status of ≤ 2 and normal hepatic and renal function. Response to therapy and toxicity ...
Tópico(s): Endometriosis Research and Treatment
2009 - Elsevier BV | European Journal of Cancer Supplements