Steven Shukor, Jonathan Northcroft, Waldemar Januszczak, John Dugdale, Hala Jaber, Dr Gill Morgan Chief Executive, Matthew Wall, Helena Frith Powell, Barbara Hall, Louie, Jeff Dawson, Lt Col (retired) B Clayton, Marianne Philips, Mark Ellingham founder of Rough Guides, N J, Fred Redwood, Jim Munro, Peter Whittle, Michael Burleigh, Helen Davies, Sally Brock, Nicholas Rufford, Rob Hughes, John Peter, V S, Pam Barrett, Limousine liberal, Mark Hodgkinson, William Lewis Business Editor, Jim Brotton, Jonathan Miller, Anne Everett, Professor Gideon Garter, Elisabeth Hoodless Executive Director, Barry Mitchell, Susan d'Arcy, J D, Hugh Morgan, Sally Emerson, Tim Nagle, David Mayers, Gareth Walsh, Peter Wade, Frank Whitford, Ivo Tennant, Alphonoso Toweh, David Gower, Kathryn Cooper, John Kerr, Peter Salter, Susan Bell, Heather Wadcock, Mia Ogden, David Smith, P D, Tim Richards, Paul Broks, David Cracknell Political Editor, Neil Wormald, Catalina Guirado, Andrew Sullivan, Clive Davis, Benedict Allen, Patricid Nicol, Richard Hamblyn, Andrew Porter, Graeme Wick, Chris Palmer, Joseph Dunn, Martin James, Simon Wilde, Grainne Murphy, Kevin Mitchell, Tristram Hunt, John Madejski, Robert Winnett, Irwin Stelzer, Matt Rudd, Robert Hewison, Robin Pagnamenta, Peter Wilson, John Crompton, Rosie Millard, David Dougill, Rachel Dobson, Nicholas Hellen Social Affairs Editor, Steve Haynes, Steve Kirby, Frank Graham, Frodsham, Geraldine Hackett, Jerry Daly, Rob Maul, Cally Law, David Bond, Hugh Canning, Alasdair Reid, Mike Pattenden, Jeremy Clarkson, Victoria Segal, kingston Smith, Peter Conradi, David Cairns, Stewart Lee, Nick Middleton, Patricia Nicol, Hilary Clarke, Sarah Dempster, Broughton Astley, Eben Black, Dave Pollard, John O'Donnell, Hugh Cunning, Greg Struthers, Bury St Edmunds, Walter Houser, David Eimer, Lydia Slater, Robert Helms, Avon Bulbs, Shelley von Strunckel, Giles Milton, Paula Robinson, Diana Fullbrook, Colin Thubron, Joan Armatrading, Paul Ham, Robin Scott-Elliot, Stuart Wavell, Andrew Butler, Roger Eglin, E M Middlemist, Paul Donovan, Christopher Silvester, Dawe, Vincent Crump, Martin Flett, Simon Fuller, Hugh McIlvanney, Chris Woodhead, Elspeth Callender, Paul Wray, Lucinda Kemeny, D Burgess, Jasper Gerard, Paul Driver, Martin Penner, Simon Fanshawe, John Humphrys, Michael Boyd-Carpenter, Nicholas Hellen, Richard Brooks, Sally Jones, Ian Hawkey, Dori Schmetterling, Alex Clark, Rupert, Ray Rodgers, Mark Ludlow, John Marx, Jonathon Carr-Brown Health Correspondent, Alicia Wyllie, Robert Pfeiffer, Mark Edwards, Susan Clark, Cheryl Swinton, Hugh McLlvanney, Eben Black Chief Political Correspondent, Harriet Perry, Martin Jacques, Anna Lawlor, Phil Baker, Hugo Barnacle, Christina Lamb, Victoria O'Brien, Clive Richardson, Raymond Keene, Berni Cozzi, Gareth Huw Davies, David Cracknell, Cosmo Landesman, Zoe Brennan, Lynn de Rothschild, Katrina Manson, Robbie Hudson, Diana Wright, Anthony Gould, Helen Hawkins, Dominic O'Connell, Robbie Burns, Barry Flatman, Nick Cain, Louise Armitstead, Brian Stothard, Tim Moorey, M J, Caroline Donald, Nick Rennison, S D, Kate Rew, Rob Ryan, James Mottram, Jessica Brinton, David Walsh, Leslie Appleyard, Trevor Lewis, Rainer Becker, Colin McDowell, Stephen Armstrong, John Elliott, Anabel Cutler, Bethan Cole, R W Johnson, Jonathan Leake Environment Editor, Richard Woods, Roland White, Shane Watson, Howard Wyman, William Rees-Mogg, Maurice Chittenden, Monsieur Mangetout, Peter Fisk chief executive of the Chartered Institute of Marketing, Tom Cox, Richard Brooks Arts Editor, Richard Rae, Mark Franchetti, Craig Lord, Mel Webb, Jon Ungoed-Thomas, George Harvey, Ray Hutton, Lauren Quaintance, Claude Aitken, Alec James Stewart, John Crossland, Michael Sheridan, Marian Salzman, Clare Francis, John Harlow, Dipesh Gadher, Hunter Davies, A A Gill, Robert Mayes, Melanie McDonagh, James Miller, Denis Walsh, Matthew Campbell, Martin Wroe, Tom Hennigan, Alan Frommer, Maria Chooza, Nick Fielding, Mary Braid, Lauren St John, Stephen Pettitt, Claudia Croft, Jonathan Calvert, Maurfce Chittenden, John Spurling, T L, Jane Cattani, Maria McErlane, Emma Richards, Sally Kinnes, Shelly Stares, Naomi Caine, David Wickers, Nigel Powell, Karen Jennings Unison Head of Health, Roger Dobson, John Reeves, Andreas Brosjo, Emily Jewsbury, Jeremy Lazell, Leo Lewis, Andrew Frankel, Howard Cohen, Graham Norwood, Jonathan Futrell, James Knight, Rupert Steiner, David Budworth, William Lewis Business editor, Hugh Pearman, Andrew Davidson, Paul Stephen Lubicz, Dan Cairns, Pearly Queen, Mike Flannery, David Smith Economics Editor, Ben Rooney, Tanya Streeter, Sarah Baxter, Helen Vandevelde, Benjamin Wootliff, J Griffiths, Matthew Goodman, India Knight, Ed Hughes, Adrian Somerfield, Dominic Rushe, Richard Lewis, Karen Robinson, Mary S Lovell,
... read by Helen Leader Einstein in Love Il Gigante Behindlings Dirt Music Murder in the museum John ...
2003 - Gale Group | Sunday Times HA GDA
Angelina Gigante, Léo Duchêne, Romain Moury, Marion Pupier, Arndt Remhof, Hans Hagemann,
Abstract All‐solid‐state batteries (ASSBs) promise higher power and energy density than batteries based on liquid electrolytes. Recently, a stable 3 V ASSB based on the super ionic conductor (1 mS cm −1 near room temperature) Na 4 (B 12 H 12 )(B 10 H 10 ) has demonstrated excellent cycling stability. This study concerns the development of a five‐step, scalable, and solution‐based synthesis of Na 4 (B 12 H 12 )(B 10 H 10 ). The use of a wet chemistry approach allows solution processing with high throughput and ...
Tópico(s): Advancements in Battery Materials
2019 - Wiley | ChemSusChem
Daniele Liuzzi, Angelo Fabio Gigante, Antonio Leo, Giovanni Defazio,
Tópico(s): Genetic Neurodegenerative Diseases
2016 - Springer Science+Business Media | Neurological Sciences
Biagio Moretti, Antonio Spinarelli, Giustino Varrassi, Leo Massari, Antonio Gigante, Giovanni Iolascon, Maria Grazia Benedetti, Anna Maria Moretti,
The exact nature of sex and gender differences in knee osteoarthritis (OA) among patient candidates for total knee arthroplasty (TKA) remains unclear and requires better elucidation to guide clinical practice. The purpose of this investigation was to survey physician practices and perceptions about the influence of sex and gender on knee OA presentation, care, and outcomes after TKA.The survey questions were elaborated by a multidisciplinary scientific board composed of 1 pain specialist, 4 orthopedic ...
Tópico(s): Knee injuries and reconstruction techniques
2021 - Springer Science+Business Media | MUSCULOSKELETAL SURGERY
Romain Moury, Zbigniew Łodziana, Arndt Remhof, Léo Duchêne, Elsa Roedern, Angelina Gigante, Hans Hagemann,
closo -Borates, such as Na 2 B 12 H 12 , are an emerging class of ionic conductors that show promising chemical, electrochemical and mechanical properties as electrolytes in all-solid-state batteries. Motivated by theoretical predictions, high-pressure in situ powder X-ray diffraction on Na 2 B 12 H 12 was performed and two high-pressure phases are discovered. The first phase transition occurs at 0.5 GPa and it is persistent to ambient pressure, whereas the second transition takes place between 5.7 ...
Tópico(s): Rare-earth and actinide compounds
2019 - Wiley | Acta Crystallographica Section B Structural Science Crystal Engineering and Materials
Cyril Planchais, I. Fernández, Timothée Bruel, Guilherme Dias de Melo, Matthieu Prot, Maxime Beretta, Pablo Guardado‐Calvo, Jérémy Dufloo, Luis M. Molinos‐Albert, Marija Backović, Jeanne Chiaravalli, Émilie Giraud, Benjamin Vesin, Laurine Conquet, Ludivine Grzelak, Delphine Planas, Isabelle Staropoli, Florence Guivel‐Benhassine, Thierry Hieu, Mikaël Boullé, Minerva Cervantes-Gonzalez, Marie‐Noëlle Ungeheuer, Pierre Charneau, Sylvie van der Werf, Fabrice Agou, Marie Bartoli, Alpha Diallo, Soizic Le Mestre, Christelle Paul, Ventzislava Petrov–Sanchez, Yazdan Yazdanpanah, C. Ficko, Catherine Chirouze, Claire Andréjak, Denis Malvy, François Goehringer, Patrick Rossignol, Tristan Gigante, Morgane Gilg, Bénédicte Rossignol, Manuel Etienne, Marine Beluze, Delphine Bachelet, Krishna Bhavsar, Lila Bouadma, Minerva Cervantes-Gonzalez, Anissa Chair, Charlotte Charpentier, Léo Chenard, Camille Couffignal, Marie‐Pierre Debray, Diane Descamps, Xavier Duval, Philippine Eloy, Marina Esposito‐Farèse, Aline-Marie Florence, Jade Ghosn, Isabelle Hoffmann, Ouifiya Kafif, Antoine Khalil, Nadhem Lafhej, Cédric Laouénan, Samira Laribi, Minh Quan Lê, Quentin Le Hingrat, Sophie Letrou, France Mentré, Gilles Peytavin, Valentine Piquard, Carine Roy, Marion Schneider, Helen C. Su, Coralie Tardivon, Jean‐François Timsit, Sarah Tubiana, Benoît Visseaux, Dominique Deplanque, Jean‐Sébastien Hulot, Jean‐Luc Diehl, Olivier Picone, François Angoulvant, Amal Abrous, Sandrine Couffin-Cadièrgues, Fernanda Dias Da Silva, Hélène Esperou, Ikram Houas, Salma Jaafoura, Aurélie Papadopoulos, Alexandre Gaymard, Bruno Lina, Manuel Rosa‐Calatrava, Céline Dorival, Jérémie Guedj, Guillaume Lingas, Nadège Néant, Laurent Abel, Victoria Manda, Sylvie Behillil, Vincent Enouf, Yves Lévy, Aurélie Wiedemann, Laurence Arowas, Blanca Liliana Perlaza, Louise Perrin de Facci, Sophie Chaouche, Linda Sangari, Charlotte Renaudat, Sandrine Fernandes Pellerin, Cassandre van Platen, Nathalie Jolly, Lucie Kuhmel, Valentine Garaud, Hantaniaina Rafanoson, Soazic Gardais, Nathalie de Parseval, Claire Dugast‐Darzacq, Caroline Jannet, Sandrine Ropars, Fanny Momboisse, Isabelle Porteret, Isabelle Cailleau, Bruno Hoen, Laura Tondeur, Camille Besombes, Arnaud Fontanet, Jordan D. Dimitrov, Etienne Simon‐Lorière, Hervé Bourhy, Xavier Montagutelli, F.A. Rey, Olivier Schwartz, Hugo Mouquet,
Memory B-cell and antibody responses to the SARS-CoV-2 spike protein contribute to long-term immune protection against severe COVID-19, which can also be prevented by antibody-based interventions. Here, wide SARS-CoV-2 immunoprofiling in Wuhan COVID-19 convalescents combining serological, cellular, and monoclonal antibody explorations revealed humoral immunity coordination. Detailed characterization of a hundred SARS-CoV-2 spike memory B-cell monoclonal antibodies uncovered diversity in their repertoire ...
Tópico(s): Complement system in diseases
2022 - Rockefeller University Press | The Journal of Experimental Medicine
Romain Moury, Zbigniew Łodziana, Arndt Remhof, Léo Duchêne, Elsa Roedern, Angelina Gigante, Hans Hagemann,
In this work, we report on the structural properties of alkali hydrido-closo-(car)borates, a promising class of solid-state electrolyte materials, using high-pressure and temperature-dependent X-ray diffraction experiments combined with density functional theory (DFT) calculations. The mechanical properties are determined via pressure-dependent diffraction studies and DFT calculations; the shear moduli appear to be very low for all studied compounds, revealing their high malleability (that can be ...
Tópico(s): Rare-earth and actinide compounds
2022 - American Chemical Society | Inorganic Chemistry
Tommaso Dionisi, Luisa Sestito, Claudia Tarli, Massimo Antonelli, Alberto Tosoni, Stefano D’Addio, Antonio Mirijello, Gabriele Vassallo, Lorenzo Leggio, Antonio Gasbarrini, Giovanni Addolorato, Valeria Abbate, Nicola Acampora, Fabiana Agostini, Maria Elena Ainora, Elena Amato, Gloria Andriollo, B.E. Annicchiarico, Gabriele Antonucci, Alessandro Armuzzi, Christian Barillaro, Fabiana Barone, Rocco Bellantone, Daniela Belella, Andrea Bellieni, Andrea Benicchi, Francesca Benvenuto, Filippo Berloco, Roberto Bernabei, Antonio Bianchi, Luigi M. Biasucci, Stefano Bibbò, Federico Biscetti, Nicola Bonadia, Alberto Borghetti, Giulia Bosco, Silvia Laura Bosello, Vincenzo Bove, Giulia Bramato, Vincenzo Brandi, Dario Bruno, Maria Chiara Bungaro, Alessandro Buonomo, Maria Livia Burzo, Angelo Calabrese, Andrea Cambieri, Giulia Cammá, Marcello Candelli, Gennaro Capalbo, Lorenzo Capaldi, Esmeralda Capristo, Luigi Carbone, Silvia Cardone, Angelo Carfì, Annamaria Carnicelli, Claudia Carnuccio, Cristiano Caruso, Francesco Antonio Casciaro, Lucio Catalano, Roberto Cauda, Andrea Leonardo Cecchini, Lucia Cerrito, Michele Ciaburri, Rossella Cianci, Sara Cicchinelli, Arturo Ciccullo Francesca Ciciarello, A. Cingolani, Maria Camilla Cipriani, Gaetano Coppola, Andrea Corsello, Federico Costante, Marcello Covino, A. D'Alessandro, Maria E. D'Alfonso, Emanuela D’Angelo, Marco D'Angelo, F. D’Aversa, Alessandro D’Errico, Fernando Damiano, Tommaso de Cunzo, Giuseppe De Matteis, Martina De Siena, Francesco Vito, Valeria Del Gatto, Paola Del Giacomo, Fabio Del Zompo, Davide Antonio Della Polla, Elisabetta Del Sordo, Luca Di Gialleonardo, Simona Di Giambenedetto, Roberta Di Luca, Luca Di Maurizio, Alex Dusina, Alessandra Esperide, Domenico Faliero, Cinzia Falsiroli, Massimo Fantoni, Annalaura Fedele, Daniela Feliciani, Daniele Ferrarese, Andrea Flex, Evelina Forte, Francesco Franceschi, Laura Franza, B. Funaro, Mariella Fuorlo, Domenico Fusco, Maurizio Gabrielli, Eleonora Gaetani, Antonella Gallo, Giovanni Gambassi, Matteo Garcovich, Irene Gasparrini, Silvia Gelli, Antonella Giampietro, Laura Gigante, Gabriele Giuliano, Giuliano Giorgia, Bianca Giupponi, Elisa Gremese, Caterina Guidone, Amerigo Iaconelli, Angela Iaquinta, Michele Impagnatiello, Riccardo Inchingolo, Raffaele Iorio, Immacolata Izzi, Cristina Kadhim, Daniele Ignazio La Milia, Francesco Landi, Giovanni Landi, Rosario Landi, Massimo Leo, Antonio Liguori, Rosa Liperoti, Marco Maria Lizzio, Maria Rita Lo Monaco, Pietro Locantore, Francesco Lombardi, Loris Riccardo Lopetuso, Valentina Loria, Angela Raffaella Losito, Noemi Macerola, G. Maiuro, Francesco Antonio Mancarella, Francesca Mangiola, A Manno, Sergio Mannucci, Debora Marchesini, Giuseppe Marrone, Ilaria Martis, Anna Maria Martone, Emanuele Marzetti, Maria Valeria Matteo, Luca Miele, Alessio Migneco, Irene Mignini, Alessandro Milani, Domenico Milardi, Massimo Montalto, Flavia Monti, Davide Moschese, Barbara P. L. Mothaenje, Celeste Ambra Murace, Rita Murri, Marco Napoli, Elisabetta Nardella, G. Natalello, Simone Navarra, Antonio Nesci, Maria Anna Nicolazzi, Alberto Nicoletti, Tommaso Nicoletti, R Nicolò, Nicola Nicolotti, Enrico Celestino Nista, Eugenia Nuzzo, Veronica Ojetti, Francesco Pagano, Cristina Pais, Maria Pallozzi, Alfredo Papa, Luigi Giovanni Papparella, Mattia Paratore, Giuseppe Parrinello, Giovanni Pecorini, Simone Perniola, Erika Pero, Claudia Petito, Luca Petricca, Martina Petrucci, Chiara Picarelli, Andrea Piccioni, Giulia Pignataro, R Pignataro, Marco Pizzoferrato, Fabrizio Pizzolante, Roberto Pola, Caterina Policola, Maurizio Pompili, Valerio Pontecorvi, Francesca Romana Ponziani, Valentina Popolla, Enrica Porceddu, Angelo Porfidia, Giuseppe Privitera, Daniela Pugliese, Gabriele Pulcini, S. Racco, Francesca Raffaelli, Gian Ludovico Rapaccini, Luca Richeldi, Emanuele Rinninella, Sara Rocchi, Stefano Romano, Federico Rosa, Laura Rossi, Rossi Raimondo, Enrica Rossini, Elisabetta Rota, Fabiana Rovedi, G Rumi, Andrea Russo, Luca Sabia, Andrea Salerno, Sara Salini, Lucia Salvatore, Samori Dehara, Maurizio Sanguinetti, Luca Santarelli, Paolo Santini, Angelo Santoliquido, Francesco Santopaolo, Michele Santoro, Francesco Sardeo, Caterina Sarnari, Luisa Saviano, Tommaso Schepis, Francesca Schiavello, Giancarlo Scoppettuolo, Carlo Romano Settanni, Valentina Siciliano, Benedetta Simeoni, Andrea Smargiassi, Domenico Staiti, Leonardo Stella, Eleonora Taddei, Talerico Rossella, Enrica Tamburrini, Pietro Tilli, Enrico Torelli, Matteo Tosato, Luca Tricoli, Marcello Tritto, Mario Tumbarello, Anita Maria Tummolo, Federico Valletta, G. Ventura, Lucrezia Verardi, Lorenzo Maria Vetrone, Giuseppe Vetrugno, Elena Visconti, Raffaella Zaccaria, Lorenzo Zelano, Lorenzo Zileri Dal Verme, Giuseppe Zuccalà,
Background and aims The COVID-19 pandemic represents a source of stress and potential burnout for many physicians. This single-site survey aimed at assessing perceived stress and risk to develop burnout syndrome among physicians operating in COVID wards. Methods This longitudinal survey evaluated stress and burnout in 51 physicians operating in the COVID team of Gemelli Hospital, Italy. Participants were asked to complete the Maslach Burnout Inventory (MBI) and the Perceived Stress Questionnaire ...
Tópico(s): Stress and Burnout Research
2021 - Wiley | International Journal of Clinical Practice
Stefany González-de Leo, Neftalí Rodríguez-Ramírez, Yasser Rizo-García, Iván Romero-García,
Tópico(s): Corporate Finance and Governance
2017 - | Revista Mexicana de Angiolog�a
Tài Pham, Leo Heunks, Giacomo Bellani, Fabiana Madotto, Irene Aragão, G. Béduneau, Ewan C. Goligher, Giacomo Grasselli, Jon Henrik Laake, Jordi Mancebo, Óscar Peñuelas, Lise Piquilloud, Antonio Pesenti, Hannah Wunsch, Frank van Haren, Laurent Brochard, John G. Laffey, Fekri Abrough, Subhash P Acharya, Pravin Amin, Yaseen Arabi, Irene Aragão, Philippe Bauer, G. Béduneau, Jeremy R. Beitler, Johan Berkius, Jesús Carazo, Luigi Camporota, Vladimír Černý, Young-Jae Cho, Kevin Clarkson, Elisa Estenssoro, Ewan Goligher, Giacomo Grasselli, Alexey Gritsan, Seyed Mohammadreza Hashemian, Greet Hermans, Leo Heunks, Bojan Jovanovic, Kiyoyasu Kurahashi, Jon Henrik Laake, Dimitrios Matamis, Onnen Moerer, Zsolt Molnar, Ezgi Özyılmaz, Bernardo Panka, Alfred Papali, Óscar Peñuelas, Sébastien Perbet, Lise Piquilloud, Haibo Qiu, Assem Abdel Razek, Nuttapol Rittayamai, Rollin Roldán, Ary Serpa Neto, Konstanty Szułdrzyński, Daniel Talmor, Dana Tomescu, Frank Van Haren, Asisclo Villagomez, Amine Ali Zeggwagh, Toshikazu Abe, Abdelrhman Aboshady, Melanie Acampo-de Jong, Subhash Acharya, Jane Adderley, Nalan Adıgüzel, Vijay Kumar Agrawal, Gerardo Aguilar, Gaston Aguirre, Hernán Aguirre-Bermeo, Björn Ahlström, Türkay Akbas, Mustafa Akker, Ghamdan Al Sadeh, Sultan H. Alamri, Ángela Algaba, Muneeb Ali, Anna Aliberti, Jose Manuel Allegue, Diana Alvarez, Joaquin Amador, Finn H Andersen, Sharique Ansari, Yutthana Apichatbutr, Olympia Apostolopoulou, Yaseen Arabi, Daniel H. Arellano, Mestanza Arica, Hüseyin Arıkan, Koichi Arinaga, Jean-Michel Arnal, Kengo Asano, Marta Asín-Corrochano, Jesus Milagrito Avalos Cabrera, Silvia Avila Fuentes, Semih Aydemir, Gülbin Aygencel, Luciano César Pontes Azevedo, Feza Bacakoğlu, Julio Badié, Elias Baedorf Kassis, Gabriela Bai, Govindan Balaraj, Bruno Ballico, Valerie Banner-Goodspeed, Preveen Banwarie, Rosella Barbieri, Arvind Baronia, Jonathan Barrett, Loïc Barrot, Jesús Emilio Barrueco-Francioni, J. Barry, Philippe Bauer, Harshal Bawangade, Sarah Beavis, Eduardo Beck, Niña Beehre, Alberto Belenguer-Muncharaz, Giacomo Bellani, Mirko Belliato, Agrippino Bellissima, Rodrigo Beltramelli, Asma Ben Souissi, Adela Benítez-Cano, Mohamed Ghit Benlamin, Abdellatif Benslama, Luís Bento, Daniela Benvenuti, Johan Berkius, Laura Bernabe, Andrew Bersten, Giacomo Berta, Pietro Bertini, Elliot Bertram-Ralph, Kamel Besbes, Lisandro Roberto Bettini, Pascal Beuret, Jeremy Bewley, Marco Bezzi, Lakshay Bhakhtiani, Rakesh Bhandary, Kaushik Bhowmick, Shailesh Bihari, Bernie Bissett, David Blythe, Simon Bocher, Narain Boedjawan, Christine M. Bojanowski, Elisa Boni, Sabrina Boraso, Massimo Borelli, Silvina Borello, Margarita Borislavova, Karen J. Bosma, Maurizio Bottiroli, Owen Boyd, Suha Bozbay, Arturo Briva, Laurent Brochard, Cédric Bruel, Andrea Bruni, Ulrike Buehner, Guillermo Bugedo, Pierre Bulpa, Karen Burt, Mathieu Buscot, Stefania Buttera, Jorge Julio Cabrera, Roberta Caccese, Pietro Caironi, Ivan Canchos Gutierrez, Nancy Canedo, Alma Cani, Iacopo Cappellini, Jesús Carazo, Luis Pablo Cardonnet, David Carpio, Demetrio Carriedo, Ramón Carrillo, João Teles Carvalho, Eliana Bernadete Caser, Antonio Castelli, Manuel Castillo Quintero, Heloísa Castro, Nuno Catorze, Melike Cengiz, Enrique Cereijo, Helga Ceunen, Christos Chaintoutis, Youjin Chang, Gustavogcha Chaparro, Carmel Chapman, Simon Chau, Cecilia Eugenia Chavez, Cosimo Chelazzi, Jonathan Chelly, Frank Chemouni, Kai Chen, Ariel Chena, P. Chiarandini, Phil Chilton, Davide Chiumello, Young-Jae Cho, Yvette Chou-Lie, Nicolas Chudeau, İsmail Cinel, Gilda Cinnella, Michele Clark, Thomas Clark, Kevin Clarkson, Stefano Clementi, Luis Coaguila, Alexis Jaspe Codecido, Amy Collins, Riccardo Colombo, Juan Conde, Guglielmo Consales, Tim Cook, Andrea Coppadoro, Rodrigo Cornejo, Andrea Cortegiani, Cristina Coxo, Andrea Cracchiolo, Mónica Crespo Ramirez, Philippe Crova, José Cruz, L. Cubattoli, Zafer Çukurova, Francesco Lo Curto, Piotr Czempik, Rocco D’Andrea, Fernando da Silva Ramos, Laurence Dangers, Marc Danguy des Déserts, Pierre-Eric Danin, Fabianne Dantas, Cédric Daubin, Wu Dawei, Candelaria de Haro, Felipe de Jesús Montelongo, Diego De Mendoza, Raúl de Pablo, Gennaro De Pascale, Silvia De Rosa, Maxens Decavèle, Pierre-Louis Declercq, Alberto Deicas, María del Carmen Campos Moreno, Jean Dellamonica, Benjamin Delmas, Oktay Demirkiran, Hilmi Demirkıran, Tarek Dendane, Rossella Di Mussi, Chrysi Diakaki, Anatilde Díaz, Willy Diaz, Yalim Dikmen, Aikaterini Dimoula, Patricia Doble, Nagwa M. Doha, Guilherme Domingos, Martin Dres, David J. Dries, Abhijit Duggal, Graeme Duke, Pavel Dunts, Knut Dybwik, Maksym Dykyy, Philippe Eckert, Serdar Efe, Souheil Elatrous, Gülseren Elay, Abubaker S Elmaryul, Mohamed Elsaadany, Hany Elsayed, Samar Elsayed, Malo Emery, Sébastien Ena, Kevin H. Eng, Joshua A. Englert, Elif Erdoğan, Perihan Ergin Özcan, Ege Eroglu, Miguel A. Escobar, Figen Esen, Arzu Esen Tekeli, Alejandro Esquivel, Helbert Esquivel Gallegos, Hanane Ezzouine, Alberto Facchini, Mohammad Faheem, Vito Fanelli, Maria Fernanda Farina, Muriel Fartoukh,
Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation.
Elsevier BV
Daniela Matuozzo, Estelle Talouarn, Astrid Marchal, Peng Zhang, Jérémy Manry, Yoann Seeleuthner, Yu Zhang, Alexandre Bolze, Matthieu Chaldebas, Baptiste Milisavljevic, Adrian Gervais, Paul Bastard, Takaki Asano, Lucy Bizien, Federica Barzaghi, Hassan Abolhassani, Ahmad Abou Tayoun, Alessandro Aiuti, Ilad Alavi Darazam, Luis M. Allende, Rebeca Alonso‐Arias, Andrés A. Arias, Gökhan Aytekіn, Peter Bergman, Simone Bondesan, Yenan T. Bryceson, Ingrid G. Bustos, Óscar Cabrera-Marante, Sheila Cárcel, Paola Carrera, Giorgio Casari, Khalil Chaïbi, Roger Colobrán, Antônio Condino‐Neto, Laura Covill, Ottavia M. Delmonte, Loubna El Zein, Carlos Flores, Peter K. Gregersen, Marta Gut, Filomeen Haerynck, Rabih Halwani, Selda Hançerli, Lennart Hammarström, Nevin Hatipoğlu, Adem Karbuz, Sevgi Keleş, Christèle Kyheng, Rafael León‐López, José Luis Franco, Davood Mansouri, Javier Martínez‐Picado, Özge Metin Akcan, Isabelle Migeotte, Pierre‐Emmanuel Morange, Guillaume Morelle, Andrea Martín-Nalda, Giuseppe Novelli, Antonio Novelli, Tayfun Özçelık, Figen Palabıyık, Qiang Pan‐Hammarström, Rebeca Pérez de Diego, Laura Planas‐Serra, Daniel E. Pleguezuelo, Carolina Prando, Aurora Pujol, Luis Felipe Reyes, Jacques G. Rivière, Carlos Rodríguez‐Gallego, Julián Rojas, Patrizia Rovere‐Querini, Agatha Schlüter, Mohammad Shahrooei, Ali Sobh, Pere Soler‐Palacín, Yacine Tandjaoui-Lambiotte, Imran Tipu, Cristina Tresoldi, Jesús Troya, Diederik van de Beek, Mayana Zatz, Paweł Zawadzki, Saleh Zaid Al-Muhsen, Mohammed F. Alosaimi, Fahad Alsohime, Hagit Baris Feldman, Manish J. Butte, Stefan N. Constantinescu, Megan A. Cooper, Clifton L. Dalgard, Jacques Fellay, James R. Heath, YL Lau, Richard P. Lifton, Tom Maniatis, Trine H. Mogensen, Horst von Bernuth, Alban Lermine, Michel Vidaud, Anne Boland, Jean‐François Deleuze, Robert Nussbaum, Amanda Kahn-Kirby, France Mentré, Sarah Tubiana, Guy Gorochov, Florence Tubach, Pierre Hausfater, Laurent Abel, Saleh Al‐Muhsen, Fahd Al‐Mulla, Mark Anderson, Evangelos Andreakos, Andrés A. Arias, Hagit Baris Feldman, Alexandre Bélot, Catherine M. Biggs, Dusan Bogunovic, Анастасія Бондаренко, Ahmed Aziz Bousfiha, Petter Brodin, Yenan T. Bryceson, Carlos D. Bustamante, Samya Chakravorty, John Christodoulou, Murkesh Desai, Beth A. Drolet, Jamila El Baghdadi, Sara Elva Espinosa‐Padilla, José Luis Franco, Antoine Froidure, David Hagin, Sarah E. Henrickson, Elena W.Y. Hsieh, Eystein S. Husebye, Kohsuke Imai, Yuval Itan, Erich D. Jarvis, Timokratis Karamitros, Kai Kisand, Cheng‐Lung Ku, Yun Ling, C. Lucas, László Maródi, Isabelle Meyts, Joshua D. Milner, Kristina Mironska, Tomohiro Morio, Lisa F. P. Ng, Luigi D. Notarangelo, Cliona OʼFarrelly, Satoshi Okada, Anna M. Planas, Lluís Quintana‐Murci, Laurent Rénia, Igor Resnick, Carlos Rodríguez‐Gallego, Vanessa Sancho‐Shimizu, Anna Šedivá, Mikko Seppänen, Anna Shcherbina, Ondřej Slabý, Andrew L. Snow, Pere Soler‐Palacín, András N. Spaan, Ivan Tancevski, Stuart G. Tangye, Sathishkumar Ramaswamy, Stuart E. Turvey, K. M. Furkan Uddin, Mohammed Uddin, Diederik van de Beek, Donald C. Vinh, Mayana Zatz, Helen C. Su, Jean‐Laurent Casanova, Serge Bureau, Yannick Vacher, Anne Gysembergh-Houal, Lauren Demerville, Abla Chachoua, Sébastien Abad, Radhiya Abassi, Abdelrafie Abdellaoui, Abdelkrim Abdelmalek, Hendy Abdoul, Hélène Abergel, Fariza Abeud, Sophie Abgrall, Noémie Abisror, Marylise Adechian, Nordine Aderdour, Hakeem Farid Admane, Frédéric Adnet, Sara Afritt, Hélène Agostini, Claire Aguilar, Sophie Agut, Tommaso Francesco Aiello, Marc Ait Kaci, Hafid Aït-Oufella, Gokula Ajeenthiravasan, Virginie Alauzy, Fanny Alby‐Laurent, Lucie Allard, Marie‐Alexandra Alyanakian, Blanca Amador Borrero, Sabrina Amam, Lucile Amrouche, M. Andronikof, Dany Anglicheau, Nadia Anguel, Djillali Annane, Mohammed Aounzou, C. Aparicio, Gladys Aratus, Jean‐Benoît Arlet, Jérémy Arzoine, E. Aslangul, Mona Assefi, Adeline Aubry, Laetitia Audiffred, Étienne Audureau, Christelle Nathalie Auger, Jean-Charles Aurégan, Celine Awotar, Sonia Ayllon Milla, Delphine Azan, Laurene Azemar, Billal Azzouguen, Marwa Bachir Elrufaai, Aïda Badsi, Prissile Bakouboula, Coline Balcerowiak, Fanta Balde, Elodie Baldivia, Eliane-Flore Bangamingo, Amandine Baptiste, Fanny Baran‐Marszak, Caroline Barau, Nathalie Barget, Flore Baronnet, Romain Barthélémy, Jean-Luc Baudel, Camille Baudry, Élodie Baudry, Laurent Beaugerie, Adel Belamri, Nicolas Belaube, Rhida Belilita, Pierre Bellassen, Rawan Belmokhtar, Isabel Beltrán, Ruben Benaïnous, Mourad Benallaoua, Robert Benamouzig, Amélie Benbara, Jaouad Benhida, Anis Benkhelouf, Jihene Benlagha, Chahinez Benmostafa, Skander Benothmane, Miassa Bentifraouine, Laurence Bérard, Quentin Bernier, Emilio Berti, Astrid Bertier, Laure Berton, Simon Bessis, Alexandra Beurton, Céline Bianco, Clara Bianquis, Frank Bidar, P. Blanche, Clarisse Blayau, Alexandre Bleibtreu, Emmanuelle Blin, Coralie Bloch‐Queyrat, Marie‐Christophe Boissier, Diane Bollens, Marion Bolzoni, Rudy pierre Bompard, Nicolas Bonnet, Justine Bonnouvrier, Shirmonecrystal Botha, Wissam Boucenna, Fatiha Bouchama, Olivier Bouchaud, Hanane Bouchghoul, Taoueslylia Boudjebla, Noel Boudjema, Catherine Bouffard, Adrien Bouglé, Meriem Bouguerra, Leila Bouras,
Abstract Background We previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15–20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in ~ 80% of cases. Methods We report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening ...
BioMed Central
Jérémy Manry, Paul Bastard, Adrian Gervais, Tom Le Voyer, Jérémie Rosain, Quentin Philippot, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Shohei Eto, Marina Garcia‐Prat, Lucy Bizien, Alba Parra-Martínez, Rui Yang, Liis Haljasmägi, Mélanie Migaud, Karita Särekannu, Julia Maslovskaja, Nicolas de Prost, Yacine Tandjaoui-Lambiotte, Charles‐Édouard Luyt, Blanca Amador-Borrero, Alexandre Gaudet, Julien Poissy, Pascal Morel, Pascale Richard, Fabrice Cognasse, Jesús Troya, Sophie Trouillet‐Assant, Alexandre Bélot, Kahina Saker, Pierre Garçon, Jacques G. Rivière, Jean‐Christophe Lagier, Stéphanie Gentile, Lindsey B. Rosen, Elana Shaw, Tomohiro Morio, Junko Tanaka, David Dalmau, Pierre‐Louis Tharaux, D. Sène, Alain Stépanian, Bruno Mégarbane, Vasiliki Triantafyllia, Arnaud Fekkar, James R. Heath, José Luis Franco, Juan‐Manuel Anaya, Jordi Solé‐Violán, Luisa Imberti, Andrea Biondi, Paolo Bonfanti, Riccardo Castagnoli, Ottavia M. Delmonte, Yu Zhang, Andrew L. Snow, Steven M. Holland, Catherine M. Biggs, Marcela Moncada‐Vélez, Andrés A. Arias, Lazaro Lorenzo, Soraya Boucherit, Dany Anglicheau, Anna M. Planas, Filomeen Haerynck, Sotiriјa Duvlis, Tayfun Özçelık, Sevgi Keleş, Ahmed Aziz Bousfiha, Jalila El Bakkouri, Carolina Ramírez‐Santana, Stéphane Paul, Qiang Pan‐Hammarström, Lennart Hammarström, Annabelle Dupont, Alina Kurolap, Christine N. Metz, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Fabio Ciceri, Lucila Akune Barreiros, Elena Domínguez‐Garrido, Mateus Vidigal, Mayana Zatz, Diederik van de Beek, Sabina Sahanic, Ivan Tancevski, Yuriy Stepanovskyy, Oksana Boyarchuk, Yoko Nukui, Miyuki Tsumura, Loreto Vidaur, Stuart G. Tangye, Sonia Burrel, Darragh Duffy, Lluís Quintana‐Murci, Adam Klocperk, Nelli Y. Kann, Anna Shcherbina, YL Lau, Daniel Leung, Matthieu Coulongeat, Julien Marlet, Rutger Koning, Luis Felipe Reyes, Angélique Chauvineau‐Grenier, Fabienne Venet, Guillaume Monneret, Michel C. Nussenzweig, Romain Arrestier, Idris Boudhabhay, Hagit Baris Feldman, David Hagin, Joost Wauters, Isabelle Meyts, Adam H. Dyer, Seán Kennelly, Nollaig M. Bourke, Rabih Halwani, Fatemeh Saheb Sharif‐Askari, Karim Dorgham, Jérôme Sallette, Souad Mehlal Sedkaoui, Suzan A. AlKhater, Raül Rigo‐Bonnin, Francisco Morandeira, Lucie Roussel, Donald C. Vinh, Christian Erikstrup, Antônio Condino‐Neto, Carolina Prando, Анастасія Бондаренко, András N. Spaan, Laurent Gilardin, Jacques Fellay, Stanislas Lyonnet, Kaya Bilgüvar, Richard P. Lifton, Shrikant Mane, Mark S. Anderson, Bertrand Boisson, Vivien Béziat, Shen‐Ying Zhang, Evangelos Andreakos, Olivier Hermine, Aurora Pujol, Pärt Peterson, Trine H. Mogensen, Lee Rowen, James Mond, Stéphanie Debette, Xavier de Lamballerie, Charles Burdet, Lila Bouadma, Marie Zins, Pere Soler‐Palacín, Roger Colobrán, Guy Gorochov, Xavier Solanich, Sophie Susen, Javier Martínez‐Picado, Didier Raoult, Marc Vasse, Peter K. Gregersen, Lorenzo Piemonti, Carlos Rodríguez‐Gallego, Luigi D. Notarangelo, Helen C. Su, Kai Kisand, Satoshi Okada, Anne Puel, Emmanuelle Jouanguy, Charles M. Rice, Pierre Tiberghien, Qian Zhang, Jean‐Laurent Casanova, Laurent Abel, Aurélie Cobat, Peng Zhang, Yoann Seeleuthner, Estelle Talouarn, Astrid Marchal, Daniela Matuozzo, Aliénor de la Chapelle, Jie Chen, Maya Chrabieh, Dana Liu, Yelena Nemirowskaya, Inés Marín Cruz, Marie Materna, Sophie Pelet, C Thibault, Xiaogang Li, Jorge Abad, Giulia Accordino, Cristian Achille, Sergio Aguilera, Aina Aguiló‐Cucurull, Alessandro Aiuti, Esra Akyüz Özkan, Ilad Alavi Darazam, Jonathan Antonio Roblero Albisures, Juan C. Aldave, Miquel Alfonso Ramos, Sajid Ali, Anna Aliberti, Seyed Alireza Nadji, Gülsüm Alkan, Suzan A. AlKhater, Jérôme Allardet-Servent, Luís M. Allende, Rebeca Alonso‐Arias, Mohammed Alshahrani, Laia Alsina, Marie‐Alexandra Alyanakian, Blanca Amador Borrero, Zahir Amoura, Arnau Antolí, Romain Arrestier, Mélodie Aubart, Teresa Auguet, Iryna Avramenko, Gökhan Aytekіn, Axelle Azot, Seiamak Bahram, Fanny Bajolle, Fausto Baldanti, Aurélie Baldolli, Mayte Ballester, Hagit Baris Feldman, Benoı̂t Barrou, Federica Barzaghi, Sabrina Basso, Gülsüm İclal Bayhan, Alexandre Bélot, Liliana Bezrodnik, Agurtzane Bilbao, Géraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blázquez‐Gamero, Alexandre Bleibtreu, Markéta Bloomfield, Mireia Bolívar-Prados, Анастасія Бондаренко, A. Borghesi, Raphaël Borie, Elisabeth Botdhlo-Nevers, Ahmed Aziz Bousfiha, Aurore Bousquet, David Boutolleau, Claire Bouvattier, Oksana Boyarchuk, Juliette Bravais, M. Luisa Briones, Marie-Eve Brunner, Raffaele Bruno, Maria Rita Passos‐Bueno, Huda Bukhari, Jacinta Bustamante, Juan José Cáceres Agra, Ruggero Capra, Raphaël Carapito, Maria Carrabba, Giorgio Casari, Carlos Casasnovas, Marion Caseris, Irene Cassaniti, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus Vidigal de Castro, Émilie Catherinot, Jale Bengi Çelik, Alessandro Ceschi, Martin Chalumeau, Bruno Charbit, Matthew Pellan Cheng, Père Clavé, Bonaventura Clotet, Anna Codina, Yves Cohen, Roger Colobrán, Cloé Comarmond, Alain Combes, Patrizia Comoli, Angelo Guido Corsico, Taner Çoşkuner, Aleksandar Cvetkovski, Cyril Cyrus, David Dalmau, François Danion, D.R. Darley, Vincent Das, Nicolás Dauby,
Significance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general ...
National Academy of Sciences
Qian Zhang, Paul Bastard, Zhiyong Liu, Jérémie Le Pen, Marcela Moncada‐Vélez, Jie Chen, Masato Ogishi, Ira K. D. Sabli, Stephanie Hodeib, Cecilia B. Korol, Jérémie Rosain, Kaya Bilgüvar, Junqiang Ye, Alexandre Bolze, Benedetta Bigio, Rui Yang, Andrés A. Arias, Qinhua Zhou, Yu Zhang, Fanny Onodi, Sarantis Korniotis, Léa Karpf, Quentin Philippot, Marwa Chbihi, Lucie Bonnet‐Madin, Karim Dorgham, Nikaïa Smith, William M. Schneider, Brandon S. Razooky, Hans-Heinrich Hoffmann, Eleftherios Michailidis, Leen Moens, Ji Eun Han, Lazaro Lorenzo, Lucy Bizien, Philip Meade, Anna‐Lena Neehus, Aileen Camille Ugurbil, Aurélien Corneau, Gaspard Kerner, Peng Zhang, Franck Rapaport, Yoann Seeleuthner, Jérémy Manry, Cécile Masson, Yohann Schmitt, Agatha Schlüter, Tom Le Voyer, Taushif Khan, Juan Li, Jacques Fellay, Lucie Roussel, Mohammad Shahrooei, Mohammed F. Alosaimi, Davood Mansouri, Haya Al‐Saud, Fahd Al‐Mulla, Feras Almourfi, Saleh Zaid Al-Muhsen, Fahad Alsohime, Saeed Al Turki, Rana Hasanato, Diederik van de Beek, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angiò, Paolo Bonfanti, Luisa Imberti, Alessandra Sottini, Simone Paghera, Eugenia Quirós-Roldán, Camillo Rossi, Andrew J. Oler, Miranda F. Tompkins, Camille Alba, Isabelle Vandernoot, Jean‐Christophe Goffard, Guillaume Smits, Isabelle Migeotte, Filomeen Haerynck, Pere Soler‐Palacín, Andrea Martín-Nalda, Roger Colobrán, Pierre‐Emmanuel Morange, Sevgi Keleş, Fatma Çölkesen, Tayfun Özçelık, Kadriye Kart Yaşar, Sevtap Şenoğlu, Şemsi̇ Nur Karabela, Carlos Rodríguez‐Gallego, Giuseppe Novelli, Sami Hraiech, Yacine Tandjaoui-Lambiotte, Xavier Duval, Cédric Laouénan, Andrew L. Snow, Clifton L. Dalgard, Joshua D. Milner, Donald C. Vinh, Trine H. Mogensen, Nico Marr, András N. Spaan, Bertrand Boisson, Stéphanie Boisson‐Dupuis, Jacinta Bustamante, Anne Puel, Michael J. Ciancanelli, Isabelle Meyts, Tom Maniatis, Vassili Soumelis, Ali Amara, Michel C. Nussenzweig, Adolfo Garcı́a-Sastre, Florian Krammer, Aurora Pujol, Darragh Duffy, Richard P. Lifton, Shen‐Ying Zhang, Guy Gorochov, Vivien Béziat, Emmanuelle Jouanguy, Vanessa Sancho‐Shimizu, Charles M. Rice, Laurent Abel, Luigi D. Notarangelo, Aurélie Cobat, Helen C. Su, Jean‐Laurent Casanova, Giuseppe Foti, Giacomo Bellani, Giuseppe Citerio, Ernesto Contro, Alberto Pesci, Maria Grazia Valsecchi, Marina Elena Cazzaniga, Jorge Abad, Sergio Aguilera, Özge Metin Akcan, Ilad Alavi Darazam, Juan C. Aldave, Miquel Alfonso Ramos, Seyed Alireza Nadji, Gülsüm Alkan, Jérôme Allardet-Servent, Luís M. Allende, Laia Alsina, Marie‐Alexandra Alyanakian, Blanca Amador-Borrero, Zahir Amoura, Arnau Antolí, Şevket Arslan, Sophie Trouillet‐Assant, Teresa Auguet, Axelle Azot, Fanny Bajolle, Aurélie Baldolli, Mayte Ballester, Hagit Baris Feldman, Benoı̂t Barrou, Alexandra Beurton, Agurtzane Bilbao, Géraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blázquez‐Gamero, Markéta Bloomfield, Mireia Bolívar-Prados, Raphaël Borie, Cédric Bosteels, Ahmed Aziz Bousfiha, Claire Bouvattier, Oksana Boyarchuk, Maria Rita Passos‐Bueno, Jacinta Bustamante, Juan José Cáceres Agra, Semra Calimli, Ruggero Capra, Maria Carrabba, Carlos Casasnovas, Marion Caseris, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus Vidigal de Castro, Émilie Catherinot, Martin Chalumeau, Bruno Charbit, Matthew P. Cheng, Père Clavé, Bonaventura Clotet, Anna Codina, Fatih Çölkesen, Fatma Çölkesen, Roger Colobrán, Cloé Comarmond, David Dalmau, D.R. Darley, Nicolás Dauby, Stéphane Dauger, Loïc de Pontual, Amin Dehban, Geoffroy Delplancq, Alexandre Demoule, Jean‐Luc Diehl, Stephanie Dobbelaere, Sophie Durand, Waleed Eldars, Mohamed Elgamal, Marwa H. Elnagdy, Melike Emiroğlu, Emine Hafize Erdeniz, Selma Erol Aytekin, Romain Euvrard, Recep Evcen, Fabio Gavarini, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernández‐Arquero, Carlos Flores, Bruno François, Victòria Fumadó, Francesca Fusco, Blanca García‐Solis, Pascale Gaussem, Juana Gil-Herrera, Laurent Gilardin, Monica Girona Alarcon, Mònica Girona‐Alarcón, Jean‐Christophe Goffard, Funda Gök, Rafaela González-Montelongo, Antoine Guerder, Yahya Gül, Şükrü Nail Güner, Marta Gut, Jérôme Hadjadj, Filomeen Haerynck, Rabih Halwani, Lennart Hammarström, Nevin Hatipoğlu, Elisa Hernández-Brito, Cathérine Heijmans, M.S. Holanda Peña, Juan Pablo Horcajada, Levi Hoste, Eric A. J. Hoste, Sami Hraiech, L. Humbert, Alejandro Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María J. Arranz, Iolanda Jordán, Philippe G. Jorens, Fikret Kanat, Hasan Kapaklı, Iskender Kara, Adem Karbuz, Kadriye Kart Yaşar, Sevgi Keleş, Yasemin Kendir Demirkol, Adam Klocperk, Zbigniew Król, Paul Kuentz, Mike Yat Wah Kwan, Jean‐Christophe Lagier, Bart N. Lambrecht, YL Lau, Fleur Le Bourgeois, Yee‐Sin Leo, Rafael León‐López, Daniel Leung, Michael Levin, Michaël Levy, Romain Lévy, Zhi Li, Agnès Linglart, Bart Loeys, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Charles‐Édouard Luyt, David Chien Lye, Davood Mansouri, Majid Marjani, Jesus Marquez Pereira, Andrea Martín‐Nalda, David Martínez Pueyo, Javier Martínez‐Picado, Iciar Marzana, Alexis Mathian, Larissa R. B. Matos, Gail Matthews,
The genetics underlying severe COVID-19 The immune system is complex and involves many genes, including those that encode cytokines known as interferons (IFNs). Individuals that lack specific IFNs can be more susceptible to infectious diseases. Furthermore, the autoantibody system dampens IFN response to prevent damage from pathogen-induced inflammation. Two studies now examine the likelihood that genetics affects the risk of severe coronavirus disease 2019 (COVID-19) through components of this system ( ...
American Association for the Advancement of Science
Paul Bastard, Lindsey B. Rosen, Qian Zhang, Eleftherios Michailidis, Hans-Heinrich Hoffmann, Yu Zhang, Karim Dorgham, Quentin Philippot, Jérémie Rosain, Vivien Béziat, Jérémy Manry, Elana Shaw, Liis Haljasmägi, Pärt Peterson, Lazaro Lorenzo, Lucy Bizien, Sophie Trouillet‐Assant, Kerry Dobbs, Adriana A. de Jesus, Alexandre Bélot, Anne Kallaste, Émilie Catherinot, Yacine Tandjaoui-Lambiotte, Jérémie Le Pen, Gaspard Kerner, Benedetta Bigio, Yoann Seeleuthner, Rui Yang, Alexandre Bolze, András N. Spaan, Ottavia M. Delmonte, Michael S. Abers, Alessandro Aiuti, Giorgio Casari, Vito Lampasona, Lorenzo Piemonti, Fabio Ciceri, Kaya Bilgüvar, Richard P. Lifton, Marc Vasse, David M. Smadja, Mélanie Migaud, Jérôme Hadjadj, Benjamin Terrier, Darragh Duffy, Lluís Quintana‐Murci, Diederik van de Beek, Lucie Roussel, Donald C. Vinh, Stuart G. Tangye, Filomeen Haerynck, David Dalmau, Javier Martínez‐Picado, Petter Brodin, Michel C. Nussenzweig, Stéphanie Boisson‐Dupuis, Carlos Rodríguez‐Gallego, Guillaume Vogt, Trine H. Mogensen, Andrew J. Oler, Jingwen Gu, Peter D. Burbelo, Jeffrey I. Cohen, Andrea Biondi, Laura Rachele Bettini, Mariella D’Angiò, Paolo Bonfanti, Patrick Rossignol, Julien Mayaux, Frédéric Rieux‐Laucat, Eystein S. Husebye, Francesca Fusco, Matilde Valeria Ursini, Luisa Imberti, Alessandra Sottini, Simone Paghera, Eugenia Quirós-Roldán, Camillo Rossi, Riccardo Castagnoli, Daniela Montagna, Amelia Licari, Gian Luigi Marseglia, Xavier Duval, Jade Ghosn, John S. Tsang, Raphaela Goldbach‐Mansky, Kai Kisand, Michail S. Lionakis, Anne Puel, Shen‐Ying Zhang, Steven M. Holland, Guy Gorochov, Emmanuelle Jouanguy, Charles M. Rice, Aurélie Cobat, Luigi D. Notarangelo, Laurent Abel, Helen C. Su, Jean‐Laurent Casanova, Andrés A. Arias, Bertrand Boisson, Soraya Boucherit, Jacinta Bustamante, Marwa Chbihi, Jie Chen, Maya Chrabieh, Tatiana Kochetkov, Tom Le Voyer, Dana Liu, Yelena Nemirovskaya, Masato Ogishi, Dominick Papandrea, Cécile Patissier, Franck Rapaport, Manon Roynard, Natasha Vladikine, Mark Woollett, Peng Zhang, Anuj Kashyap, Li Ding, Marita Bosticardo, Qinlu Wang, Sebastian Ochoa, Hui Liu, Samuel D. Chauvin, Michael Stack, Galina Koroleva, Neha Bansal, Clifton L. Dalgard, Andrew L. Snow, Jorge Abad, Sergio Aguilera, Özge Metin Akcan, Ilad Alavi Darazam, Juan C. Aldave, Miquel Alfonso Ramos, Seyed Alireza Nadji, Gülsüm Alkan, Jérôme Allardet-Servent, Luís M. Allende, Laia Alsina, Marie‐Alexandra Alyanakian, Blanca Amador-Borrero, Zahir Amoura, Arnau Antolí, Şevket Arslan, Sophie Assant, Teresa Auguet, Axelle Azot, Fanny Bajolle, Aurélie Baldolli, Mayte Ballester, Hagit Baris Feldman, Benoı̂t Barrou, Alexandra Beurton, Agurtzane Bilbao, Géraldine Blanchard-Rohner, Ignacio Blanco, Adeline Blandinières, Daniel Blázquez‐Gamero, Markéta Bloomfield, Mireia Bolívar-Prados, Raphaël Borie, Ahmed Aziz Bousfiha, Claire Bouvattier, Oksana Boyarchuk, Maria Rita Passos‐Bueno, Jacinta Bustamante, Juan José Cáceres Agra, Semra Calimli, Ruggero Capra, Maria Carrabba, Carlos Casasnovas, Marion Caseris, Martin Castelle, Francesco Castelli, Martín Castillo de Vera, Mateus Vidigal de Castro, Émilie Catherinot, Martin Chalumeau, Bruno Charbit, Matthew Pellan Cheng, Père Clavé, Bonaventura Clotet, Anna Codina, Fatih Çölkesen, Fatma Çölkesen, Roger Colobrán, Cloé Comarmond, Angelo Guido Corsico, David Dalmau, D.R. Darley, Nicolás Dauby, Stéphane Dauger, Loïc de Pontual, Amin Dehban, Geoffroy Delplancq, Alexandre Demoule, Antonio Di Sabatino, Jean‐Luc Diehl, Stephanie Dobbelaere, Sophie Durand, Waleed Eldars, Mohamed Elgamal, Marwa H. Elnagdy, Melike Emiroğlu, Emine Hafize Erdeniz, Selma Erol Aytekin, Romain Euvrard, Recep Evcen, Fabio Gavarini, Laurence Faivre, Antonin Falck, Muriel Fartoukh, Morgane Faure, Miguel Fernández‐Arquero, Carlos Flores, Bruno François, Victòria Fumadó, Francesca Fusco, Blanca García‐Solis, Pascale Gaussem, Juana Gil-Herrera, Laurent Gilardin, Monica Girona Alarcon, Mònica Girona‐Alarcón, Jean‐Christophe Goffard, Funda Gök, Rafaela González-Montelongo, Antoine Guerder, Yahya Gül, Şükrü Nail Güner, Marta Gut, Jérôme Hadjadj, Filomeen Haerynck, Rabih Halwani, Lennart Hammarström, Nevin Hatipoğlu, Elisa Hernández-Brito, M.S. Holanda Peña, Juan Pablo Horcajada, Sami Hraiech, L. Humbert, Alejandro Iglesias, Antonio Íñigo-Campos, Matthieu Jamme, María J. Arranz, Iolanda Jordán, Fikret Kanat, Hasan Kapaklı, Iskender Kara, Adem Karbuz, Kadriye Kart Yaşar, Sevgi Keleş, Yasemin Kendir Demirkol, Adam Klocperk, Zbigniew Król, Paul Kuentz, Mike Yat Wah Kwan, Jean‐Christophe Lagier, YL Lau, Fleur Le Bourgeois, Yee‐Sin Leo, Rafael León‐López, Daniel Leung, Michael Levin, Michaël Levy, Romain Lévy, Zhi Li, Agnès Linglart, José M. Lorenzo-Salazar, Céline Louapre, Catherine Lubetzki, Charles‐Édouard Luyt, David Chien Lye, Davood Mansouri, Majid Marjani, Jesus Marquez Pereira, Andrea Martín‐Nalda, David Martínez Pueyo, Javier Martínez‐Picado, Iciar Marzana, Alexis Mathian, Larissa R. B. Matos, Gail Matthews, Julien Mayaux, Jean‐Louis Mège, Isabelle Melki, Jean–François Méritet, Özge Metin Akcan, Isabelle Meyts, Mehdi Mezidi, Isabelle Migeotte, Maude Millereux, Tristan Mirault, Clotilde Mircher,
Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), or against both (52) at the onset of critical disease; a few also had auto-Abs against the other three type I IFNs. ...
American Association for the Advancement of Science
... smj.3494Stefano Caselli, Stefano Gatti, Carlo Chiarella, Gimede Gigante, Giulia Negri Do shareholders really matter for firm ... 1331677X.2020.1865827Claudio Fernandez-Araoz, Carrie Green, Gregory Leo Nagel Corporate Succession Practices and the Impact on ...
Tópico(s): Working Capital and Financial Performance
1983 - University of Chicago Press | The Journal of Law and Economics
Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Gina M. Peloso, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Ming‐Huei Chen, Martin L. Buchkovich, Samia Mora, J. Beckmann, Jennifer L. Bragg‐Gresham, Hsing‐Yi Chang, Ayşe Demirkan, Heleen M. den Hertog, Ron Do, Louise A. Donnelly, Georg Ehret, Tõnu Esko, Mary F. Feitosa, Teresa Ferreira, Krista Fischer, Pierre Fontanillas, Ross M. Fraser, Daniel F. Freitag, Deepti Gurdasani, Kauko Heikkilä, Elina Hyppönen, Aaron Isaacs, Anne Jackson, Åsa Johansson, Toby Johnson, Marika Kaakinen, Johannes Kettunen, Marcus E. Kleber, Xiaohui Li, Jian’an Luan, Leo‐Pekka Lyytikäinen, Patrik K. E. Magnusson, Massimo Mangino, Evelin Mihailov, May E. Montasser, Martina Müller‐Nurasyid, Ilja M. Nolte, Jeffrey R. O’Connell, Cameron D. Palmer, Markus Perola, Ann-Kristin Petersen, Serena Sanna, Richa Saxena, Susan K. Service, Sonia Shah, Dmitry Shungin, Carlo Sidore, Ci Song, Rona J. Strawbridge, Ida Surakka, Toshiko Tanaka, Tanya M. Teslovich, Guðmar Þorleifsson, Evita G. van den Herik, Benjamin F. Voight, Kelly A. Volcik, Lindsay L. Waite, Andrew Wong, Ying Wu, Weihua Zhang, Devin Absher, Gershim Asiki, Inês Barroso, Latonya Been, Jennifer L. Bolton, Lori L. Bonnycastle, Paolo Brambilla, Mary Susan Burnett, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Döring, Paul Elliott, Stephen E. Epstein, Guðmundur I. Eyjólfsson, Bruna Gigante, Mark O. Goodarzi, Harald Grallert, Martha L. Gravito, Christopher J. Groves, Göran Hallmans, Anna-Liisa Hartikainen, Caroline Hayward, Dena Hernández, Andrew A. Hicks, Hilma Hólm, Yi-Jen Hung, Thomas Illig, Michelle R. Jones, Pontiano Kaleebu, John J.P. Kastelein, Kay‐Tee Khaw, Eric H. Kim, Norman Klopp, Pirjo Komulainen, Meena Kumari, Claudia Langenberg, Terho Lehtimäki, Shih-Yi Lin, Jaana Lindström, Ruth J. F. Loos, François Mach, Wendy L. McArdle, Christa Meisinger, Braxton D. Mitchell, Gabrielle Müller, Ramaiah Nagaraja, Narisu Narisu, Tuomo Nieminen, Rebecca N. Nsubuga, Ísleifur Ólafsson, Ken K. Ong, Aarno Palotie, Theodore Papamarkou, Cristina Pomilla, Anneli Pouta, Daniel J. Rader, Muredach P. Reilly, Paul M. Ridker, Fernando Rivadeneira, Igor Rudan, Aimo Ruokonen, Nilesh J. Samani, Hubert Scharnagl, Janet Seeley, Kaisa Silander, Alena Stančáková, Kathleen Stirrups, Amy J. Swift, Laurence Tiret, André G. Uitterlinden, L. Joost van Pelt, Sailaja Vedantam, Nicholas W.J. Wainwright, Cisca Wijmenga, Sarah H. Wild, Gonneke Willemsen, Tom Wilsgaard, James F. Wilson, Elizabeth Young, Jing Hua Zhao, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn I. Bennett, Murielle Bochud, Bernhard O. Boehm, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet, Michel Burnier, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Yii-Der Ida Chen, Francis S. Collins, Stephen S. Rich, John Danesh, George Dedoussis, Ulf dé Fairé, Alan B. Feranil, Jean Ferrières, Luigi Ferrucci, Nelson B. Freimer, Christian Gieger, Leif Groop, Vilmundur Guðnason, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Aroon D. Hingorani, Joel N. Hirschhorn, Albert Hofman, G. Kees Hovingh, Chao A. Hsiung, Steve E. Humphries, Steven C. Hunt, Kristian Hveem, Carlos Iribarren, Marjo‐Riitta Järvelin, Antti Jula, Mika Kähönen, Jaakko Kaprio, Antero Kesäniemi, Mika Kivimäki, Jaspal S. Kooner, Peter J. Koudstaal, Ronald M. Krauss, Diana Kuh, Johanna Kuusisto, Kirsten Ohm Kyvik, Markku Laakso, Timo A. Lakka, Lars Lind, Cecilia M. Lindgren, Nicholas G. Martin, Winfried März, Mark I. McCarthy, Colin A. McKenzie, Pierre Meneton, Andres Metspalu, Leena Moilanen, Andrew D. Morris, Patricia B. Munroe, Inger Njølstad, Nancy L. Pedersen, Chris Power, Peter P. Pramstaller, Jackie F. Price, Bruce M. Psaty, Thomas Quertermous, Rainer Rauramaa, Danish Saleheen, Veikko Salomaa, Dharambir K. Sanghera, Jouko Saramies, Peter E. H. Schwarz, Wayne H-H Sheu, Alan R. Shuldiner, Agneta Siegbahn, Tim D. Spector, Kāri Stefánsson, David P. Strachan, Bamidele O. Tayo, Elena Tremoli, Jaakko Tuomilehto, Matti Uusitupa, Cornelia M. van Duijn, Péter Vollenweider, Lars Wallentin, Nicholas J. Wareham, John B. Whitfield, Bruce H. R. Wolffenbuttel, José M. Ordovás, Eric Boerwinkle, Colin N. A. Palmer, Unnur Þorsteinsdóttir, Daniel I. Chasman, Jerome I. Rotter, Paul W. Franks, Samuli Ripatti, L. Adrienne Cupples, Manjinder S. Sandhu, Stephen S. Rich, Michael Boehnke, Panos Deloukas, Sekar Kathiresan, Karen L. Mohlke, Erik Ingelsson, Gonçalo R. Abecasis,
Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using ...
Tópico(s): Genetic and phenotypic traits in livestock
2013 - Nature Portfolio | Nature Genetics
Ron Do, Cristen J. Willer, Ellen M. Schmidt, Sebanti Sengupta, Chi Gao, Gina M. Peloso, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Jin Chen, Martin L. Buchkovich, Samia Mora, J. Beckmann, Jennifer L. Bragg‐Gresham, Hsing‐Yi Chang, Ayşe Demirkan, Heleen M. den Hertog, Louise A. Donnelly, Georg Ehret, Tõnu Esko, Mary F. Feitosa, Teresa Ferreira, Krista Fischer, Pierre Fontanillas, Ross M. Fraser, Daniel F. Freitag, Deepti Gurdasani, Kauko Heikkilä, Elina Hyppönen, Aaron Isaacs, Anne Jackson, Åsa Johansson, Toby Johnson, Marika Kaakinen, Johannes Kettunen, Marcus E. Kleber, Xiaohui Li, Jian’an Luan, Leo‐Pekka Lyytikäinen, Patrik K. E. Magnusson, Massimo Mangino, Evelin Mihailov, May E. Montasser, Martina Müller‐Nurasyid, Ilja M. Nolte, Jeffrey R. O’Connell, Colin N. A. Palmer, Markus Perola, Ann-Kristin Petersen, Serena Sanna, Richa Saxena, Susan K. Service, Sonia Shah, Dmitry Shungin, Carlo Sidore, Ci Song, Rona J. Strawbridge, Ida Surakka, Toshiko Tanaka, Tanya M. Teslovich, Guðmar Þorleifsson, Evita G. van den Herik, Benjamin F. Voight, Kelly A. Volcik, Lindsay L. Waite, Andrew Wong, Ying Wu, Weihua Zhang, Devin Absher, Gershim Asiki, Inês Barroso, Latonya Been, Jennifer L. Bolton, Lori L. Bonnycastle, Paolo Brambilla, Mary Susan Burnett, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Döring, Paul Elliott, Stephen E. Epstein, Guðmundur I. Eyjólfsson, Bruna Gigante, Mark O. Goodarzi, Harald Grallert, Martha L. Gravito, Christopher J. Groves, Göran Hallmans, Anna-Liisa Hartikainen, Caroline Hayward, Dena Hernandez, Andrew A. Hicks, Hilma Hólm, Yi-Jen Hung, Thomas Illig, Michelle R. Jones, Pontiano Kaleebu, John J.P. Kastelein, Kay‐Tee Khaw, Eric H. Kim, Norman Klopp, Pirjo Komulainen, Meena Kumari, Claudia Langenberg, Terho Lehtimäki, Shih-Yi Lin, Jaana Lindström, Ruth J. F. Loos, François Mach, Wendy L. McArdle, Christa Meisinger, Braxton D. Mitchell, Gabrielle Müller, Ramaiah Nagaraja, Narisu Narisu, Tuomo Nieminen, Rebecca N. Nsubuga, Ísleifur Ólafsson, Ken K. Ong, Aarno Palotie, Theodore Papamarkou, Cristina Pomilla, Anneli Pouta, Daniel J. Rader, Muredach P. Reilly, Paul M. Ridker, Fernando Rivadeneira, Igor Rudan, Aimo Ruokonen, Nilesh J. Samani, Hubert Scharnagl, Janet Seeley, Kaisa Silander, Alena Stančáková, Kathleen Stirrups, Amy J. Swift, Laurence Tiret, André G. Uitterlinden, L. Joost van Pelt, Sailaja Vedantam, Nicholas W.J. Wainwright, Cisca Wijmenga, Sarah H. Wild, Gonneke Willemsen, Tom Wilsgaard, James F. Wilson, Elizabeth Young, Jing Hua Zhao, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn I. Bennett, Murielle Bochud, Bernhard O. Boehm, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet, Michel Burnier, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Yii-Der Ida Chen, Francis S. Collins, Stephen S. Rich, John Danesh, George Dedoussis, Ulf dé Fairé, Alan B. Feranil, Jean Ferrières, Luigi Ferrucci, Nelson B. Freimer, Christian Gieger, Leif Groop, Vilmundur Guðnason, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Aroon D. Hingorani, Joel N. Hirschhorn, Albert Hofman, G. Kees Hovingh, Chao A. Hsiung, Steve E. Humphries, Steven C. Hunt, Kristian Hveem, Carlos Iribarren, Marjo‐Riitta Järvelin, Antti Jula, Mika Kähönen, Jaakko Kaprio, Antero Kesäniemi, Mika Kivimäki, Jaspal S. Kooner, Peter J. Koudstaal, Ronald M. Krauss, Diana Kuh, Johanna Kuusisto, Kirsten Ohm Kyvik, Markku Laakso, Timo A. Lakka, Lars Lind, Cecilia M. Lindgren, Nicholas G. Martin, Winfried März, Mark I. McCarthy, Colin A. McKenzie, Pierre Meneton, Andres Metspalu, Leena Moilanen, Andrew D. Morris, Patricia B. Munroe, Inger Njølstad, Nancy L. Pedersen, Chris Power, Peter P. Pramstaller, Jackie F. Price, Bruce M. Psaty, Thomas Quertermous, Rainer Rauramaa, Danish Saleheen, Veikko Salomaa, Dharambir K. Sanghera, Jouko Saramies, Peter E. H. Schwarz, Wayne H-H Sheu, Alan R. Shuldiner, Agneta Siegbahn, Tim D. Spector, Kāri Stefánsson, David P. Strachan, Bamidele O. Tayo, Elena Tremoli, Jaakko Tuomilehto, Matti Uusitupa, Cornelia M. van Duijn, Péter Vollenweider, Lars Wallentin, Nicholas J. Wareham, John B. Whitfield, Bruce H. R. Wolffenbuttel, David Altshuler, José M. Ordovás, Eric Boerwinkle, Colin N. A. Palmer, Unnur Þorsteinsdóttir, Daniel I. Chasman, Jerome I. Rotter, Paul W. Franks, Samuli Ripatti, L. Adrienne Cupples, Manjinder S. Sandhu, Stephen S. Rich, Michael Boehnke, Panos Deloukas, Karen L. Mohlke, Erik Ingelsson, Gonçalo R. Abecasis, Mark J. Daly, Benjamin M. Neale, Sekar Kathiresan,
Sekar Kathiresan and colleagues examine 185 common variants using a modified mendelian randomization approach and provide evidence supporting a causal role of triglyceride-rich lipoproteins in the development of coronary artery disease. Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal ...
Nature Portfolio | Nature Genetics
Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L. Assimes, John R. Thompson, Erik Ingelsson, Danish Saleheen, Jeanette Erdmann, Benjamin A. Goldstein, Kathleen Stirrups, Inke R. König, Jean‐Baptiste Cazier, Åsa Johansson, Alistair S. Hall, Jong‐Young Lee, Cristen J. Willer, John C. Chambers, Tõnu Esko, Lasse Folkersen, Anuj Goel, Elin Grundberg, Aki S. Havulinna, Weang-Kee Ho, Jemma C. Hopewell, Niclas Eriksson, Marcus E. Kleber, Kati Kristiansson, Per Lundmark, Leo‐Pekka Lyytikäinen, Suzanne Rafelt, Dmitry Shungin, Rona J. Strawbridge, Guðmar Þorleifsson, Emmi Tikkanen, Natalie Van Zuydam, Benjamin F. Voight, Lindsay L. Waite, Weihua Zhang, Andreas Ziegler, Devin Absher, David Altshuler, Anthony J. Balmforth, Inês Barroso, Peter S. Braund, Christof Burgdorf, Xueling Sim, David Cox, Maria Dimitriou, Ron Do, Alex S. F. Doney, NourEddine El Mokhtari, Per Eriksson, Krista Fischer, Pierre Fontanillas, Anders Franco‐Cereceda, Bruna Gigante, Per‐Henrik Groop, Stefan Gustafsson, Jörg Hager, Göran Hallmans, Bok-Ghee Han, Sarah Hunt, Hyun Min Kang, Thomas Illig, Thorsten Kessler, Joshua Knowles, Genovefa Kolovou, Johanna Kuusisto, Claudia Langenberg, Cordelia Langford, Karin Leander, Marja‐Liisa Lokki, Anders Lundmark, Mark I. McCarthy, Christa Meisinger, Olle Melander, Evelin Mihailov, Seraya Maouche, Andrew D. Morris, Martina Müller‐Nurasyid, Kjell Nikus, John F. Peden, Nigel W. Rayner, Asif Rasheed, Silke Rosinger, Deborah C. Rubin, Moritz Rumpf, Arne Schäfer, Mohan U. Sivananthan, Ci Song, Alexandre F.R. Stewart, Sian-Tsung Tan, Guðmundur Þorgeirsson, C. Ellen van der Schoot, Peter J. Wagner, George A. Wells, Philipp S. Wild, Tsun-Po Yang, Philippe Amouyel, Dominique Arveiler, Hanneke Basart, Michael Boehnke, Eric Boerwinkle, Paolo Brambilla, François Cambien, L. Adrienne Cupples, Ulf dé Fairé, Abbas Dehghan, Patrick Diemert, Stephen E. Epstein, Alun Evans, Maurizio Ferrario, Jean Ferrières, Dominique Gauguier, Alan S. Go, Alison H. Goodall, Vilmundur Guðnason, Stanley L. Hazen, Hilma Hólm, Carlos Iribarren, Yangsoo Jang, Mika Kähönen, Frank Kee, Hyo‐Soo Kim, Norman Klopp, Wolfgang Köenig, Wolfgang Kratzer, Kari Kuulasmaa, Markku Laakso, Reijo Laaksonen, Ji‐Young Lee, Lars Lind, Willem H. Ouwehand, Sarah Parish, Jeong E. Park, Nancy L. Pedersen, Annette Peters, Thomas Quertermous, Daniel J. Rader, Veikko Salomaa, Eric E. Schadt, Svati H. Shah, Juha Sinisalo, Klaus Stark, Kāri Stefánsson, David‐Alexandre Trégouët, Jarmo Virtamo, Lars Wallentin, Nicholas J. Wareham, Martina E. Zimmermann, Markku S. Nieminen, Christian Hengstenberg, Manjinder S. Sandhu, Tomi Pastinen, Ann-Christine Syvänen, G. Kees Hovingh, George Dedoussis, Paul W. Franks, Terho Lehtimäki, Andres Metspalu, Pierre Zalloua, Agneta Siegbahn, Stefan Schreiber, Samuli Ripatti, Stefan S Blankenberg, Markus Perola, Robert Clarke, Bernhard O. Boehm, Christopher J. O’Donnell, Muredach P. Reilly, Winfried März, Rory Collins, Sekar Kathiresan, Anders Hamsten, Jaspal S. Kooner, Unnur Þorsteinsdóttir, John Danesh, Colin N. A. Palmer, Robert Roberts, Hugh Watkins, Heribert Schunkert, Nilesh J. Samani,
Coronary artery disease (CAD) is the commonest cause of death. Here, we report an association analysis in 63,746 CAD cases and 130,681 controls identifying 15 loci reaching genome-wide significance, taking the number of susceptibility loci for CAD to 46, and a further 104 independent variants (r(2) < 0.2) strongly associated with CAD at a 5% false discovery rate (FDR). Together, these variants explain approximately 10.6% of CAD heritability. Of the 46 genome-wide significant lead SNPs, 12 show a significant ...
Tópico(s): Kruppel-like factors research
2012 - Nature Portfolio | Nature Genetics
Leo Massari, Francesco Benazzo, Francesco Falez, Ruggero Cadossi, D Perugia, L. Pietrogrande, Domenico Aloj, Antonio Capone, Michele D’Arienzo, Matteo Cadossi, Vincenzo Lorusso, Gaetano Caruso, Matteo Ghiara, Luigi Ciolli, Filippo La Cava, Marco Guidi, Filippo Castoldi, Giuseppe Marongiu, Alessandra La Gattuta, Dario Dell’Omo, Michelangelo Scaglione, Sandro Giannini, Mattia Fortina, Alberto Riva, Pier Luigi De Palma, Antonio Gigante, Biagio Moretti, Giuseppe Solarino, Francesco Lijoi, Giovanni Giordano, Pier Giorgio Londini, Danilo Castellano, Giuseppe Sessa, Luciano Costarella, Antonio Barile, Mariano Borrelli, A. Rota, Raffaele Fontana, Alberto Momoli, Andrea Micaglio, Guido Bassi, Rossano Stefano Cornacchia, Claudio Castelli, Michele Giudici, Mauro Monesi, Luigi Branca Vergano, Pietro Maniscalco, M’Putu Bulabula, Vincenzo Zottola, Auro Caraffa, P. Antinolfi, Fabio Catani, Claudio Severino, E Castaman, Carmelo Scialabba, Venceslao Tovaglia, Pietro Corsi, Paolo Friemel, Marco Ranellucci, Vincenzo Caiaffa, Giovanni Maraglino, Roberto Rossi, Antonio Pastrone, P. Caldora, Claudio Cusumano, P. B. SQUARZINA, Ugo Baschieri, Ettore Demattè, Stefano Gherardi, Carlo De Roberto, Alberto Belluati, Antonio Giannini, Ciro Villani, P.J. Persiani, Silvio Demitri, Bruno Di Maggio, Guglielmo Abate, Francesca de Terlizzi, Stefania Setti,
Background . Healing of tibia fractures occurs over a wide time range of months, with a number of risk factors contributing to prolonged healing. In this prospective, multicentre, observational study, we investigated the capability of FRACTING (tibia FRACTure prediction healING days) score, calculated soon after tibia fracture treatment, to predict healing time. Methods . The study included 363 patients. Information on patient health, fracture morphology, and surgical treatment adopted were combined ...
Tópico(s): Artificial Intelligence in Healthcare and Education
2018 - Hindawi Publishing Corporation | BioMed Research International
Natalie R. van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, Nigel W. Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric B. Fauman, Neil R. Robertson, Paul McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M. Loredana Marcovecchio, Robert P. Igo, Rany M. Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M. van Dam, Guozhi Jiang, Claudia H.T. Tam, Andrea O. Y. Luk, Heung Man Lee, Cadmon K.P. Lim, Cheuk‐Chun Szeto, Wing Yee So, Juliana C.N. Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy Jayne McKnight, Seamus Duffy, Marcus G. Pezzolesi, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T. Hiraki, Tarunveer S. Ahluwalia, Peter Almgren, Christina‐Alexandra Schulz, Marju Orho‐Melander, Allan Linneberg, Cramer Christensen, Daniel R. Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D. Paterson, David‐Alexandre Trégouët, Alexander P. Maxwell, Su Chi Lim, Ronald C.W., E. Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Jaakko Tuomilehto, Andrzej S. Królewski, Stephen S. Rich, Joel N. Hirschhorn, José C. Florez, David B. Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, M. Julia Brosnan, Colin N. A. Palmer, Per‐Henrik Groop, Helen M. Colhoun, Leif Groop, Mark I. McCarthy, Satu Koivula, T. Uggeldahl, Terje Forslund, A. Halonen, A. Koistinen, P. Koskiaho, M. Laukkanen, Juha Saltevo, Miia Tiihonen, M. Forsen, Helena Granlund, A.-C. Jönsson, B. Nyroos, Pentti Kinnunen, A. Orvola, Tapani Salonen, A. Vähänen, Kotka R. Paldanius, M Riihelä, L. Ryysy, Kemi H. Laukkanen, P. Nyländen, Anni Sademies, S. Anderson, Barbro Asplund, U. Byskata, P. Liedes, M. Kuusela, T. Virkkala, Anssi Nikkola, E. Ritola, Tapiola M. Niska, Harri Juhani Saarinen, Samaria E. Oukko-Ruponen, Tuula Virtanen, Viherlaakso A. Lyytinen, P H Kari, T. Simonen, Suutarila A. Kaprio, Jorma Kärkkäinen, B. Rantaeskola, Toolo P. Kääriäinen, J R Haaga, A.-L. Pietiläinen, Sanna Klemetti, T. Nyandoto, E. Rontu, S. Satuli-Autere, Korso R. Toivonen, H. Virtanen Lansimaki, Riitta Ahonen, M. Ivaska-Suomela, Anneli Jauhiainen, Martinlaakso M. Laine, T. Pellonpää, R. Puranen, Myyrmaki A. Airas, Juha Laakso, K. Rautavaara, Rekola M. Erola, E. Jatkola, Tikkurila R. Lönnblad, Anna Malm, Jyrki Mäkelä, E. Rautamo, P. Hentunen, J. Lagerstam, Maija Feodoroff, Daniel Gordin, Outi Heikkilä, Kustaa Hietala, J. Fagerudd, Minna A. Korolainen, L. Kyllönen, Janne Kytö, S. Lindh, Kim Pettersson-Fernholm, Milla Rosengård‐Bärlund, A. Sandelin, Lena M. Thorn, Jaana Tuomikangas, T. Vesisenaho, Johan Wadén, V. Sipilä, Forssa T. Kalliomäki, J. Koskelainen, R. Nikkanen, N. Savolainen, Hannu Sulonen, E. Valtonen, Leena Norvio, Anne Hämäläinen, E. Toivanen, Jamsa A. Parta, I. Pirttiniemi, S. Aranko, Satu Ervasti, Ronald C.W., Ari Kuusisto, T. Leppälä, Katriina Nikkilä, L. Pekkonen, K. Jokelainen, Kristiina Kananen, Matti Karjalainen, Pentti Kemppainen, A.-M. Mankinen, A. Reponen, M. Sankari, Pauli Suominen, Anu K. Lappalainen, Maarit Liimatainen, J. Santaholma, Ari Aimolahti, Elisa Huovinen, V. Ilkka, M. Y. Lehtimäki, E. Pälikkö-Kontinen, A. Vanhanen, E. Koskinen, Timo Siitonen, Erja Huttunen, Risto Ikäheimo, Pauli Karhapää, Päivi Kekäläinen, M. Laakso, Timo A. Lakka, E Lampainen, Leena Moilanen, Sanna Tanskanen, Leo Niskanen, U. Tuovinen, Ilkka Vauhkonen, Erkki Voutilainen, Ronald C.W., Juliana C.N. Chan, Yü Huang, Hui Y. Lan, Si Lok, Brian Tomlinson, Stephen Kwok‐Wing Tsui, Weichuan Yu, Kevin Y.L. Yip, Ting‐Fung Chan, Xiaodan Fan, Wing Yee So, Cheuk‐Chun Szeto, Nelson L.S. Tang, Andrea O. Y. Luk, Xiao Yu Tian, Guozhi Jiang, Claudia H.T. Tam, Heung Man Lee, Cadmon K.P. Lim, Kei Hang Katie Chan, Fangying Xie, Alex C.W. Ng, Grace P.Y. Cheung, Ming Wai Yeung, Mai Shi, Fei Xie, Sen Zhang, Yu Pu, Meng Weng, Alexander P. Maxwell, Amy Jayne McKnight, David A. Savage, James D. Walker, Stephen Thomas, Giancarlo Viberti, A.J.M. Boulton, S. M. Marshall, Andrew Demaine, B. A. Millward, Steve Baín, Niina Sandholm, Carol Forsblom, Valma Harjutsalo, Ville‐Petteri Mäkinen, Aila J. Ahola, Emma H. Dahlström, Daniel Gordin, Outi Heikkilä, Kustaa Hietala, Janne Kytö, Markku Lehto, Raija Lithovius, Nicolae Mircea Panduru, Maija Parkkonen, Milla Rosengård‐Bärlund, Markku Saraheimo, Jenny Söderlund, Aino Soro‐Paavonen, Anna Syreeni, Lena M. Thorn, Nina Tolonen, Johan Wadén, Per‐Henrik Groop, Amy Jayne McKnight, Gareth J. McKay, Alexander P. Maxwell, Rany M. Salem, Tamara Isakova, Colin N. A. Palmer, Candace Guiducci, Andrew M. Taylor, Daniel B. Mirel, Winfred W. Williams, Joel N. Hirschhorn, José C. Florez, Eoin Brennan, Denise M. Sadlier, Finian Martin, Catherine Godson, Lynne Mayer,
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects ...
American Diabetes Association
Produção Nacional
Revisado por pares
Yi‐Juan Hu, Amand F. Schmidt, Frank Dudbridge, Michael V. Holmes, James M. Brophy, Vinicius Tragante, Ziyi Li, Peizhou Liao, Arshed A. Quyyumi, Raymond O. McCubrey, Benjamin D. Horne, Aroon D. Hingorani, Folkert W. Asselbergs, Riyaz Patel, Long Qi, Axel Åkerblom, Ale Algra, Hooman Allayee, Peter Almgren, Jeffrey L. Anderson, Maria Grazia Andreassi, Chiara Viviani Anselmi, Diego Ardissino, Benoît J. Arsenault, Christie M. Ballantyne, E.V. Baranova, Hassan Behloui, Thomas O. Bergmeijer, Connie R. Bezzina, Eyþór Björnsson, Simon C. Body, Bram Boeckx, Eric Boersma, Eric Boerwinkle, Peter Bogaty, Peter S. Braund, Lutz Philipp Breitling, Hermann Brenner, Carlo Briguori, Jasper J. Brugts, Ralph Burkhardt, Vicky A. Cameron, John F. Carlquist, Clara Carpeggiani, Kathryn F. Carruthers, Gavino Casu, Gianluigi Condorelli, Sharon Cresci, Nicolas Danchin, Ulf dé Fairé, John Deanfield, Graciela Delgado, Panos Deloukas, Kenan Direk, Robert N. Doughty, Heinz Drexel, Núbia E. Duarte, Marie‐Pierre Dubé, Line Dufresne, James C. Engert, Niclas Eriksson, Natalie Fitzpatrick, Luisa Foco, Ian Ford, Keith A.A. Fox, Bruna Gigante, Crystel M. Gijsberts, Domenico Girelli, Yan Gong, Daníel F. Guðbjartsson, Emil Hagström, Jaana Hartiala, Stanley L. Hazen, Claes Held, Anna Helgadóttir, Harry Hemingway, Mahyar Heydarpour, Imo E. Hoefer, Kees Hovingh, Jaroslav A. Hubáček, Stefan James, Julie A. Johnson, J. Wouter Jukema, Marcin Kaczor, Karol Kamiński, Jiří Kettner, Marek Kiliszek, Marcus E. Kleber, Olaf H. Klungel, Daniel Kofink, Mika Kohonen, Salma Kotti, Pekka Kuukasjärvi, Bo Lagerqvist, Diether Lambrechts, Chim C. Lang, Jari Laurikka, Karin Leander, Vei‐Vei Lee, Terho Lehtimäki, Andreas Leiherer, Petra A. Lenzini, Daniel L. Levin, Daniel Lindholm, Marja‐Liisa Lokki, Paulo A. Lotufo, Leo‐Pekka Lyytikäinen, Bakhtawar K. Mahmoodi, Anke H. Maitland‐van der Zee, Nicola Martinelli, Winfried März, Nicola Marziliano, Ruth McPherson, Olle Melander, Ute Mons, Jochen D. Muehlschlegel, Joseph B. Muhlestein, Cristopher P. Nelson, Chris Newton Cheh, Oliviero Olivieri, Grzegorz Opolski, Colin N. A. Palmer, Guillaume Paré, Gerard Pasterkamp, Carl J. Pepine, Witold Pepiński, Alexandre C. Pereira, Anna P. Pilbrow, Louise Pilote, Jan Piťha, Rafał Płoski, Mark Richards, Christoph H. Saely, Nilesh J. Samani, Ayman Samman‐Tahhan, Marek Sanak, Pratik B. Sandesara, Naveed Sattar, Markus Scholz, Agneta Siegbahn, Tabassome Simon, Juha Sinisalo, J. G. Smith, John A. Spertus, Kāri Stefánsson, Alexandre F.R. Stewart, David J. Stott, Wojciech Szczeklik, Anna Szpakowicz, Michael W.T. Tanck, W.H. Wilson Tang, Jean‐Claude Tardif, J M Ten Berg, Andrej Teren, George Thanassoulis, Joachim Thiery, Guðmundur Þorgeirsson, Guðmar Þorleifsson, Unnur Þorsteinsdóttir, Adam Timmis, Stella Trompet, Frans Van de Werf, Yolanda van der Graaf, Pim van der Haarst, Sander W. van der Laan, Ragnar O. Vilmundarson, Salim S. Virani, Frank L.J. Visseren, Efthymia Vlachopoulou, Lars Wallentin, Johannes Waltenberger, Els Wauters, Arthur A.M. Wilde,
Background— Studies of recurrent or subsequent disease events may be susceptible to bias caused by selection of subjects who both experience and survive the primary indexing event. Currently, the magnitude of any selection bias, particularly for subsequent time-to-event analysis in genetic association studies, is unknown. Methods and Results— We used empirically inspired simulation studies to explore the impact of selection bias on the marginal hazard ratio for risk of subsequent events among those ...
Tópico(s): Cardiovascular Function and Risk Factors
2017 - Lippincott Williams & Wilkins | Circulation Cardiovascular Genetics
Anne E. Justice, Thomas W. Winkler, Mary F. Feitosa, Misa Graff, Virginia Fisher, Kristin L. Young, Llilda Barata, Xuan Deng, Jacek Czajkowski, David Hadley, Julius S. Ngwa, Tarunveer S. Ahluwalia, Audrey Y. Chu, Nancy L. Heard‐Costa, Elise Lim, Jeremiah Perez, John D. Eicher, Zoltán Kutalik, Luting Xue, Anubha Mahajan, Frida Renström, Joseph Wu, Qibin Qi, Shafqat Ahmad, Tamuno Alfred, Najaf Amin, Lawrence F. Bielak, Amélie Bonnefond, Jennifer Bragg, Gemma Cadby, Martina Chittani, Scott Coggeshall, Tanguy Corre, Neşe Direk, Joel Eriksson, Krista Fischer, Mathias Gorski, Marie Neergaard Harder, Momoko Horikoshi, Tao Huang, Jennifer E. Huffman, Anne Jackson, Johanne Marie Justesen, Stavroula Kanoni, Leena Kinnunen, Marcus E. Kleber, Pirjo Komulainen, Meena Kumari, Unhee Lim, Jian’an Luan, Leo‐Pekka Lyytikäinen, Massimo Mangino, Ani Manichaikul, Jonathan Marten, Rita P. S. Middelberg, Martina Müller‐Nurasyid, Pau Navarro, Louis Pérusse, Natalia Pervjakova, Cinzia Sarti, Albert V. Smith, Jennifer A. Smith, Alena Stančáková, Rona J. Strawbridge, Heather M. Stringham, Yan V. Sun, Toshiko Tanaka, Alexander Teumer, Stella Trompet, Sander W. van der Laan, Peter J. van der Most, Jana V. van Vliet‐Ostaptchouk, Sailaja Vedantam, Niek Verweij, Jacqueline M. Vink, Véronique Vitart, Ying Wu, Loïc Yengo, Weihua Zhang, Wei Zhao, Martina E. Zimmermann, Niha Zubair, Gonçalo R. Abecasis, Linda S. Adair, Saima Afaq, Uzma Afzal, Stephan J. L. Bakker, Traci M. Bartz, John Beilby, Richard N. Bergman, Sven Bergmann, Reiner Biffar, John Blangero, Eric Boerwinkle, Lori L. Bonnycastle, Erwin P. Böttinger, Daniele Braga, Brendan M. Buckley, Steven Buyske, Harry Campbell, John C. Chambers, Francis S. Collins, Joanne E. Curran, Gert J. de Borst, Anton J. M. de Craen, Eco J. C. de Geus, George Dedoussis, Graciela E. Delgado, Hester M. den Ruijter, Guðný Eiríksdóttir, Anna L. Eriksson, Tõnu Esko, Jessica D. Faul, Ian Ford, Terrence Forrester, Karl Gertow, Bruna Gigante, Nicola Glorioso, Jian Gong, Harald Grallert, Tanja B. Grammer, Niels Grarup, Saskia Haitjema, Göran Hallmans, Anders Hamsten, Torben Hansen, Tamara B. Harris, Catharina A. Hartman, Maija Hassinen, Nicholas D. Hastie, Andrew C. Heath, Dena Hernández, Lucia A. Hindorff, Lynne J. Hocking, Mette Hollensted, Oddgeir L. Holmen, Georg Homuth, Jouke‐Jan Hottenga, Jie Huang, Joseph Hung, Nina Hutri‐Kähönen, Erik Ingelsson, Anthony James, John-Olov Jansson, Marjo‐Riitta Järvelin, Min A. Jhun, Marit E. Jørgensen, Markus Juonala, Mika Kähönen, Magnus K. Karlsson, Heikki A. Koistinen, Ivana Kolčić, Genovefa Kolovou, Charles Kooperberg, Bernhard K. Krämer, Johanna Kuusisto, Kirsti Kvaløy, Timo A. Lakka, Claudia Langenberg, Lenore J. Launer, Karin Leander, Sang Lee, Lars Lind, Cecilia M. Lindgren, Allan Linneberg, Stéphane Lobbens, Marie Loh, Mattias Lorentzon, Robert Luben, Gitta H. Lubke, Anja Ludolph-Donislawski, Sara Lupoli, Pamela A. F. Madden, Reija Männikkö, Pedro Marques‐Vidal, Nicholas G. Martin, Colin A. McKenzie, Barbara McKnight, Dan Mellström, Cristina Menni, Grant W. Montgomery, AW Musk, Narisu Narisu, Matthias Nauck, Ilja M. Nolte, Albertine J. Oldehinkel, Matthias Olden, Ken K. Ong, Sandosh Padmanabhan, Patricia A. Peyser, Charlotta Pisinger, David J. Porteous, Olli T. Raitakari, Tuomo Rankinen, D. C. Rao, Laura J. Rasmussen‐Torvik, Rajesh Rawal, Treva Rice, Paul M. Ridker, Lynda M. Rose, Stephanie A. Bien, Igor Rudan, Serena Sanna, Mark A. Sarzynski, Naveed Sattar, Kai Savonen, David Schlessinger, Salome Scholtens, Claudia Schurmann, Robert A. Scott, Bengt Sennblad, Marten A. Siemelink, Günther Silbernagel, P. Eline Slagboom, Harold Snieder, Jan A. Staessen, David J. Stott, Morris A. Swertz, Amy J. Swift, Kent D. Taylor, Bamidele O. Tayo, Barbara Thorand, Dorothée Thuillier, Jaakko Tuomilehto, André G. Uitterlinden, Liesbeth Vandenput, Marie‐Claude Vohl, Henry Völzke, Judith M. Vonk, Gérard Waeber, Mélanie Waldenberger, Rudi G. J. Westendorp, Sarah H. Wild, Gonneke Willemsen, Bruce H. R. Wolffenbuttel, Andrew Wong, Alan F. Wright, Wei Zhao, M. Carola Zillikens, Damiano Baldassarre, Beverley Balkau, Stefania Bandinelli, Carsten A. Böger, Dorret I. Boomsma, Claude Bouchard, Marcel Bruinenberg, Daniel I. Chasman, Yii-DerIda Chen, Peter S. Chines, Stephen S. Rich, Francesco Cucca, Daniele Cusi, Ulf dé Fairé, Luigi Ferrucci, Paul W. Franks, Philippe Froguel, Penny Gordon‐Larsen, Hans J. Grabe, Vilmundur Guðnason, Christopher A. Haiman, Caroline Hayward, Kristian Hveem, Andrew D. Johnson, J. Wouter Jukema, Sharon L. R. Kardia, Mika Kivimäki, Jaspal S. Kooner, Diana Kuh, Markku Laakso, Terho Lehtimäki, Loı̈c Le Marchand, Winfried März, Mark I. McCarthy, Andres Metspalu, Andrew P. Morris, Claes Ohlsson, Lyle J. Palmer, Gerard Pasterkamp, Oluf Pedersen, Annette Peters, Ulrike Peters, Ozren Polašek, Bruce M. Psaty, Lu Qi, Rainer Rauramaa, Blair H. Smith, Thorkild I. A. Sørensen, Konstantin Strauch, Henning Tiemeier, Elena Tremoli, Pim van der Harst, Henrik Vestergaard, Péter Vollenweider, Nicholas J. Wareham, David R. Weir, John B. Whitfield,
Abstract Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with ...
Nature Portfolio
Georg Ehret, Teresa Ferreira, Daniel I. Chasman, Anne Jackson, Ellen M. Schmidt, Toby Johnson, Guðmar Þorleifsson, Jian’an Luan, Lousie A Donnelly, Stavroula Kanoni, Ann-Kristin Petersen, Vasyl Pihur, Rona J. Strawbridge, Dmitry Shungin, Maria Hughes, Osorio Meirelles, Marika Kaakinen, Nabila Bouatia‐Naji, Kati Kristiansson, Sonia Shah, Marcus E. Kleber, Xiuqing Guo, Leo‐Pekka Lyytikäinen, Cristiano Fava, Niclas Eriksson, Ilja M. Nolte, Patrik K. E. Magnusson, Elias Salfati, Lοukianos S. Rallidis, Elizabeth Theusch, Andrew J. Smith, Lasse Folkersen, Kate Witkowska, Tune H. Pers, Roby Joehanes, Stuart K. Kim, Lazaros Lataniotis, Rick Jansen, Andrew D. Johnson, Helen R. Warren, Young Jin Kim, Wei Zhao, Ying Wu, Bamidele O. Tayo, Murielle Bochud, Devin Absher, Linda S. Adair, Najaf Amin, Dan E. Arking, Tomas Axelsson, Damiano Baldassarre, Beverley Balkau, Stefania Bandinelli, Michael R. Barnes, Inês Barroso, Steve Bevan, Joshua C. Bis, Gyða Björnsdóttir, Michael Boehnke, Eric Boerwinkle, Lori L. Bonnycastle, Dorret I. Boomsma, Stefan R. Bornstein, Morris J. Brown, Michel Burnier, Claudia Cabrera, John C. Chambers, I‐Shou Chang, Ching‐Yu Cheng, Peter S. Chines, Ren-Hua Chung, Francis S. Collins, John Connell, Angela Döring, Jean Dallongeville, John Danesh, Ulf dé Fairé, Graciela Delgado, Anna F. Dominiczak, Alex S. F. Doney, Fotios Drenos, Sarah Edkins, John D. Eicher, Roberto Elosúa, Stefan Enroth, Jeanette Erdmann, Per Eriksson, Tõnu Esko, Εvangelos Εvangelou, Alun Evans, Tove Fall, Martin Farrall, Janine F. Felix, Jean Ferrières, Luigi Ferrucci, Myriam Fornage, Terrence Forrester, Nora Franceschini, Oscar H Franco Duran, Anders Franco‐Cereceda, Ross M. Fraser, Santhi K Ganesh, He Gao, Karl Gertow, Francesco Gianfagna, Bruna Gigante, Franco Giulianini, Anuj Goel, Alison H. Goodall, Mark O Goodarzi, Mathias Gorski, Jürgen Gräßler, Christopher J. Groves, Vilmundur Guðnason, Ulf Gyllensten, Göran Hallmans, Anna-Liisa Hartikainen, Maija Hassinen, Aki S. Havulinna, Caroline Hayward, Serge Herçberg, Karl-Heinz Herzig, Andrew A. Hicks, Aroon D. Hingorani, Joel N. Hirschhorn, Albert Hofman, Jostein Holmen, Oddgeir L. Holmen, Jouke‐Jan Hottenga, Phil Howard, Chao A. Hsiung, Steven C. Hunt, M. Arfan Ikram, Thomas Illig, Carlos Iribarren, Richard A. Jensen, Mika Kähönen, Hyun Min Kang, Sekar Kathiresan, Brendan J. Keating, Kay‐Tee Khaw, Yun Kyoung Kim, Eric H. Kim, Mika Kivimäki, Norman Klopp, Genovefa Kolovou, Pirjo Komulainen, Jaspal S. Kooner, Gülüm Kosova, Ronald M. Krauss, Diana Kuh, Zoltán Kutalik, Johanna Kuusisto, Kirsti Kvaløy, Timo A. Lakka, Sang Lee, I‐Te Lee, Wen‐Jane Lee, Daniel Levy, Xiaohui Li, Kae-Woei Liang, Honghuang Lin, Lin Li, Jaana Lindström, Stéphane Lobbens, Satu Männistö, Gabriele Müller, Martina Müller‐Nurasyid, François Mach, Hugh S. Markus, Eirini Marouli, Mark I. McCarthy, Colin A. McKenzie, Pierre Meneton, Cristina Menni, Andres Metspalu, Vladan Mijatovic, Leena Moilanen, May E. Montasser, Andrew D Morris, Alanna C. Morrison, Antonella Mulas, Ramaiah Nagaraja, Narisu Narisu, Kjell Nikus, Christopher J. O’Donnell, Paul F. O’Reilly, Ken K. Ong, Fred Paccaud, Cameron D. Palmer, Afshin Parsa, Nancy L. Pedersen, Brenda W.J.H. Penninx, Markus Perola, Annette Peters, Neil Poulter, Peter P. Pramstaller, Bruce M. Psaty, Thomas Quertermous, Dabeeru C Rao, Asif Rasheed, N. William Rayner, Frida Renström, Rainer Rettig, Kenneth Rice, Robert Roberts, Lynda M. Rose, Jacques Rossouw, Nilesh J. Samani, Serena Sanna, Jouko Saramies, Heribert Schunkert, Sylvain Sebért, Wayne H-H Sheu, Young-Ah Shin, Xueling Sim, Johannes H. Smit, Albert V. Smith, Maria X. Sosa, Tim D. Spector, Alena Stančáková, Alice Stanton, Kathleen Stirrups, Heather M. Stringham, Johan Sundström, Amy J. Swift, Ann‐Christine Syvänen, E. Shyong Tai, Toshiko Tanaka, Kirill V. Tarasov, Alexander Teumer, Unnur Thorsteinsdottir, Martin D. Tobin, Elena Tremoli, André G. Uitterlinden, Matti Uusitupa, Ahmad Vaez, Dhananjay Vaidya, Cornelia M. van Duijn, Erik P.A. van Iperen, Ramachandran S. Vasan, Germaine C. Verwoert, Jarmo Virtamo, Véronique Vitart, Benjamin F. Voight, Péter Vollenweider, Aline Wagner, Louise V. Wain, Nicholas J. Wareham, Hugh Watkins, Alan B. Weder, Harm-Jan Westra, Rainford Wilks, Tom Wilsgaard, James F Wilson, Tien Yin Wong, Tsun-Po Yang, Jie Yao, Loïc Yengo, Weihua Zhang, Jing Hua Zhao, Xiaofeng Zhu, Pascal Bovet, Stephen S. Rich, Karen L Mohlke, Danish Saleheen, Jong‐Young Lee, Paul Elliott, Hinco J. Gierman, Cristen J. Willer, Lude Franke, G. Kees Hovingh, Kent D. Taylor, George Dedoussis, Peter S. Sever, Andrew Wong, Lars Lind, Themistocles L. Assimes, Inger Njølstad, Peter E. H. Schwarz, Claudia Langenberg, Harold Snieder, Mark J. Caulfield, Olle Melander, Markku Laakso, Juha Saltevo, Rainer Rauramaa, Jaakko Tuomilehto, Erik Ingelsson, Terho Lehtimäki, Kristian Hveem, Walter Palmas, Winfried März, Meena Kumari, Veikko Salomaa, Yii‐Der I. Chen,
Patricia Munroe, Christopher Newton-Cheh, Andrew Morris and colleagues perform association studies in over 340,000 individuals of European ancestry and identify 66 loci, of which 17 are novel, involved in blood pressure regulation. The risk SNPs are enriched for cis-regulatory elements, particularly in vascular endothelial cells. To dissect the genetic architecture of blood pressure and assess effects on target organ damage, we analyzed 128,272 SNPs from targeted and genome-wide arrays in 201,529 ...
Nature Portfolio
Paolo Zanoni, Sumeet A. Khetarpal, Daniel B. Larach, William Hancock‐Cerutti, John S. Millar, Marina Cuchel, Stephanie DerOhannessian, Anatol Kontush, Praveen Surendran, Danish Saleheen, Stella Trompet, J. Wouter Jukema, Anton de Craen, Panos Deloukas, Naveed Sattar, Ian Ford, Chris J. Packard, Abdullah Al Shafi Majumder, Dewan S Alam, Emanuele Di Angelantonio, Gonçalo R. Abecasis, Rajiv Chowdhury, Jeanette Erdmann, Børge G. Nordestgaard, Sune F. Nielsen, Anne Tybjærg‐Hansen, Ruth Frikke‐Schmidt, Kari Kuulasmaa, Dajiang J. Liu, Markus Perola, Stefan Blankenberg, Veikko Salomaa, Satu Männistö, Philippe Amouyel, Dominique Arveiler, Jean Ferrières, Martina Müller‐Nurasyid, Maurizio Ferrario, Frank Kee, Cristen J. Willer, Nilesh J. Samani, Heribert Schunkert, Adam S. Butterworth, Joanna M. M. Howson, Gina M. Peloso, Nathan O. Stitziel, John Danesh, Sekar Kathiresan, Daniel J. Rader, Sarah Watson, Ellen M. Schmidt, Sebanti Sengupta, Stefan Gustafsson, Stavroula Kanoni, Andrea Ganna, Ming‐Huei Chen, Martin L. Buchkovich, Samia Mora, J. Beckmann, Jennifer L. Bragg‐Gresham, Hsing‐Yi Chang, Ayşe Demirkan, Heleen M. den Hertog, Ron Do, Louise A. Donnelly, Georg Ehret, Tõnu Esko, Mary F. Feitosa, Teresa Ferreira, Krista Fischer, Pierre Fontanillas, Ross M. Fraser, Daniel F. Freitag, Deepti Gurdasani, Kauko Heikkilä, Elina Hyppönen, Aaron Isaacs, Anne Jackson, Åsa Johansson, Toby Johnson, Marika Kaakinen, Johannes Kettunen, Marcus E. Kleber, Xiaohui Li, Jian’an Luan, Leo‐Pekka Lyytikäinen, Patrik K. E. Magnusson, Massimo Mangino, Evelin Mihailov, May E. Montasser, Ilja M. Nolte, Jeffrey R. O’Connell, Colin N. A. Palmer, Ann-Kristin Petersen, Serena Sanna, Richa Saxena, Susan K. Service, Sonia Shah, Dmitry Shungin, Carlo Sidore, Ci Song, Rona J. Strawbridge, Ida Surakka, Toshiko Tanaka, Tanya M. Teslovich, Guðmar Þorleifsson, Evita G. van den Herik, Benjamin F. Voight, Kelly A. Volcik, Lindsay L. Waite, Andrew Wong, Ying Wu, Weihua Zhang, Devin Absher, Gershim Asiki, Inês Barroso, Latonya Been, Jennifer L. Bolton, Lori L. Bonnycastle, Paolo Brambilla, Mary Susan Burnett, Giancarlo Cesana, Maria Dimitriou, Alex S. F. Doney, Angela Döring, Paul Elliott, Stephen E. Epstein, Guðmundur I. Eyjólfsson, Bruna Gigante, Mark O. Goodarzi, Harald Grallert, Martha L. Gravito, Christopher J. Groves, Göran Hallmans, Anna‐Liisa Hartikainen, Caroline Hayward, Dena Hernandez, Andrew A. Hicks, Hilma Hólm, Yi‐Jen Hung, Thomas Illig, Michelle R. Jones, Pontiano Kaleebu, John J.P. Kastelein, Kay‐Tee Khaw, Eric H. Kim, Norman Klopp, Pirjo Komulainen, Meena Kumari, Claudia Langenberg, Terho Lehtimäki, Shih-Yi Lin, Jaana Lindström, Ruth J. F. Loos, François Mach, Wendy L. McArdle, Christa Meisinger, Braxton D. Mitchell, Gabrielle Müller, Ramaiah Nagaraja, Narisu Narisu, Tuomo Nieminen, Rebecca N. Nsubuga, Ísleifur Ólafsson, Ken K. Ong, Aarno Palotie, Theodore Papamarkou, Cristina Pomilla, Anneli Pouta, Muredach P. Reilly, Paul M. Ridker, Fernando Rivadeneira, Igor Rudan, A Ruokonen, Hubert Scharnagl, Janet Seeley, Kaisa Silander, Alena Stančáková, Kathleen Stirrups, Amy J. Swift, Laurence Tiret, André G. Uitterlinden, L. J. van Pelt, Sailaja Vedantam, Nicholas W.J. Wainwright, Cisca Wijmenga, Sarah H. Wild, Gonneke Willemsen, Tom Wilsgaard, James F. Wilson, Elizabeth Young, Wei Zhao, Linda S. Adair, Dominique Arveiler, Themistocles L. Assimes, Stefania Bandinelli, Franklyn I. Bennett, Murielle Bochud, Bernhard O. Boehm, Dorret I. Boomsma, Ingrid B. Borecki, Stefan R. Bornstein, Pascal Bovet, Michel Burnier, Harry Campbell, Aravinda Chakravarti, John C. Chambers, Yii‐Der Ida Chen, Francis S. Collins, Stephen S. Rich, George Dedoussis, Ulf dé Fairé, Alan B. Feranil, Luigi Ferrucci, Nelson B. Freimer, Christian Gieger, Leif Groop, Vilmundur Guðnason, Ulf Gyllensten, Anders Hamsten, Tamara B. Harris, Aroon D. Hingorani, Joel N. Hirschhorn, Albert Hofman, G. Kees Hovingh, Chao A. Hsiung, Steve E. Humphries, Steven C. Hunt, Kristian Hveem, Carlos Iribarren, Marjo‐Riitta Järvelin, Antti Jula, Mika Kähönen, Jaakko Kaprio, Antero Kesäniemi, Mika Kivimäki, Jaspal S. Kooner, Peter J. Koudstaal, Ronald M. Krauss, Diana Kuh, Johanna Kuusisto, Kirsten Ohm Kyvik, Markku Laakso, Timo A. Lakka, Lars Lind, Cecilia M. Lindgren, Nicholas G. Martin, Winfried März, Mark I. McCarthy, Colin A. McKenzie, Pierre Meneton, Andres Metspalu, Leena Moilanen, Andrew D. Morris, Patricia B. Munroe, Inger Njølstad, Nancy L. Pedersen, Chris Power, Peter P. Pramstaller, Jackie F. Price, Bruce M. Psaty, Thomas Quertermous, Rainer Rauramaa, Veikko Salomaa, Dharambir K. Sanghera, Jouko Saramies, Peter E. H. Schwarz, Wayne H.-H. Sheu, Alan R. Shuldiner, Agneta Siegbahn, Tim D. Spector, Kāri Stefánsson, David P. Strachan, Bamidele O. Tayo, Elena Tremoli, Jaakko Tuomilehto, Matti Uusitupa, Cornelia M. van Duijn, Péter Vollenweider, Lars Wallentin, Nicholas J. Wareham, John B. Whitfield, Bruce H. R. Wolffenbuttel, José M. Ordovás, Eric Boerwinkle, Colin N. A. Palmer, Unnur Þorsteinsdóttir, Daniel I. Chasman, Jerome I. Rotter, Paul W. Franks, Samuli Riatti, L. Adrienne Cupples, Manjinder S. Sandhu, Stephen S. Rich, Michael Boehnke, Panos Deloukas,
A scavenger that protects the heart Coronary heart disease is a tale of two forms of plasma cholesterol. In contrast to the well-established effects of “bad” cholesterol (LDL-C), the role of “good” cholesterol (HDL-C) is mysterious. Elevated HDL-C correlates with a lower risk of heart disease, yet drugs that raise HDL-C levels do not reduce risk. Zanoni et al. found that some people with exceptionally high levels of HDL-C carry a rare sequence variant in the gene encoding the major HDL-C receptor, scavenger ...
American Association for the Advancement of Science
Veronica Ojetti, Angela Saviano, Marcello Covino, Nicola Acampora, Eliana Troiani, Francesco Franceschi, Abbate Valeria, Nicola Acampora, Giovanni Addolorato, Agostini Fabiana, Maria Elena Ainora, Akacha Karim, Elena Amato, Francesca Andreani, Gloria Andriollo, Maria Giuseppina Annetta, B.E. Annicchiarico, Massimo Antonelli, Gabriele Antonucci, Gian Marco Anzellotti, Alessandro Armuzzi, Baldi Fabiana, Barattucci Ilaria, Christian Barillaro, Fabiana Barone, Rocco Bellantone, Andrea Bellieni, Giuseppe Bello, Andrea Benicchi, Francesca Benvenuto, Berardini Ludovica, Filippo Berloco, Roberto Bernabei, Bianchi Antonio, Daniele Guerino Biasucci, Luigi M. Biasucci, Stefano Bibbò, Bini Alessandra, Alessandra Bisanti, Federico Biscetti, Maria Grazia Bocci, Nicola Bonadia, Filippo Bongiovanni, Alberto Borghetti, Bosco Giulia, Silvia Laura Bosello, Vincenzo Bove, Giulia Bramato, Vincenzo Brandi, Teresa Bruni, Carmine Bruno, Dario Bruno, Maria Chiara Bungaro, Alessandro Buonomo, Burzo Livia, Calabrese Angelo, Maria Rosaria Calvello, Andrea Cambieri, Cambise Chiara, Giulia Cammá, Marcello Candelli, Canistro Gennaro, Cantanale Antonello, Gennaro Capalbo, Lorenzo Capaldi, Emanuele Capone, Esmeralda Capristo, Luigi Carbone, Silvia Cardone, Simone Carelli, Angelo Carfì, Annamaria Carnicelli, Cristiano Caruso, Francesco Antonio Casciaro, Catalano Lucio, Roberto Cauda, Andrea Leonardo Cecchini, Lucia Cerrito, Melania Cesarano, Annalisa Chiarito, Rossella Cianci, Sara Cicchinelli, Ciccullo Arturo, Marta Cicetti, Francesca Ciciarello, A. Cingolani, Maria Camilla Cipriani, Maria Ludovica Consalvo, Gaetano Coppola, Giuseppe Maria Corbo, Andrea Corsello, Federico Costante, Costanzi Matteo, Marcello Covino, Crupi Davide, Salvatore Lucio Cutuli, D’Addio Stefano, A. D'Alessandro, Maria ElenaEmanuela D'AlfonsoD'Angelo, D’Aversa Francesca, Fernando Damiano, Gian Maria De Berardinis, Tommaso de Cunzo, Donati Katleen De Gaetano, Giulio De Luca, Giuseppe De Matteis, Gennaro De Pascale, Paolo De Santis, Martina De Siena, Francesco Vito, Valeria Del Gatto, Paola Del Giacomo, Fabio Del Zompo, Antonio Maria Dell’Anna, Davide Antonio Della Polla, Luca Di Gialleonardo, Simona Di Giambenedetto, Roberta Di Luca, Luca Di Maurizio, Mariangela Di Muro, Dusina Alex, Eleuteri Davide, Alessandra Esperide, Daniele Fachechi, Faliero Domenico, Falsiroli Cinzia, Massimo Fantoni, Annalaura Fedele, Feliciani Daniela, Ferrante Cristina, Giuliano Ferrone, R. Festa, Maria Fiore, Andrea Flex, Forte Evelina, Francesco Franceschi, Francesconi Alessandra, Laura Franza, Funaro Barbara, Mariella Fuorlo, Domenico Fusco, Maurizio Gabrielli, Eleonora Gaetani, Galletta Claudia, Antonella Gallo, Giovanni Gambassi, Garcovich Matteo, Antonio Gasbarrini, Gasparrini Irene, Gelli Silvia, Antonella Giampietro, Laura Gigante, Giuliano Gabriele, Giuliano Giorgia, Giupponi Bianca, Elisa Gremese, Domenico Luca Grieco, Manuel Guerrera, Valeria Guglielmi, Caterina Guidone, Antonio Gullì, Amerigo Iaconelli, Iafrati Aurora, Gianluca Ianiro, Angela Iaquinta, Michele Impagnatiello, Riccardo Inchingolo, Enrica Intini, Raffaele Iorio, Immacolata Izzi, Tamara Jovanović, Cristina Kadhim, Rosa La Macchia, Daniele Ignazio La Milia, Francesco Landi, Landi Giovanni, Rosario Landi, Raffaele Landolfi, Massimo Leo, Paolo Maria Leone, Laura Levantesi, Antonio Liguori, Rosa Liperoti, Marco Maria Lizzio, Maria Rita Lo Monaco, Pietro Locantore, Francesco Lombardi, Gianmarco Lombardi, Loris Riccardo Lopetuso, Loria Valentina, Angela Raffaella Losito, Mothanje Barbara Lucia, Francesco Macagno, Macerola Noemi, Maggi Giampaolo, G. Maiuro, Francesco Antonio Mancarella, Francesca Mangiola, Manno Alberto, Marchesini Debora, G Maresca, Marrone Giuseppe, Martis Ilaria, Anna Maria Martone, Emanuele Marzetti, Chiara Mattana, Maria Valeria Matteo, Riccardo Maviglia, Mazzarella Ada, Memoli Carmen, Luca Miele, Alessio Migneco, Irene Mignini, Milani Alessandro, Domenico Milardi, Montalto Massimo, Montemurro Giuliano, Flavia Monti, Luca Montini, Tony Christian Morena, Morra Vincenzina, Chiara Morretta, Davide Moschese, Celeste Ambra Murace, Martina Murdolo, Rita Murri, Marco Napoli, Elisabetta Nardella, G. Natalello, Daniele Natalini, Simone Navarra, Antonio Nesci, Nicoletti Alberto, Nicoletti Rocco, Tommaso Nicoletti, Nicolò Rebecca, Nicola Nicolotti, Enrico Celestino Nista, Eugenia Nuzzo, Oggiano Marco, Veronica Ojetti, Francesco Pagano, Paiano Gianfranco, Pais Cristina, Pallavicini Federico, Palombo Andrea, Paolillo Federico, Alfredo Papa, Papanice Domenico, Luigi Giovanni Papparella, Mattia Paratore, Giuseppe Parrinello, Giuliana Pasciuto, Pasculli Pierpaolo, Giovanni Pecorini, Simone Perniola, Erika Pero, Luca Petricca, Martina Petrucci, Picarelli Chiara, Piccioni Andrea, Piccolo Annalisa, Piervincenzi Edoardo, Giulia Pignataro, R Pignataro, Pintaudi Gabriele, Luca Pisapia, Pizzoferrato Marco, Pizzolante Fabrizio, Roberto Pola, Caterina Policola, Maurizio Pompili, Pontecorvi Flavia, Valerio Pontecorvi, Ponziani Francesca, Popolla Valentina, Porceddu Enrica, Angelo Porfidia, Lucia Maria Porro, Potenza Annalisa, Francesca Pozzana, Giuseppe Privitera, Daniela Pugliese, Gabriele Pulcini, Racco Simona, Francesca Raffaelli, Ramunno Vittoria, Gian Ludovico Rapaccini, Luca Richeldi, Emanuele Rinninella, Sara Rocchi, Bruno Romanò, Stefano Romano, Federico Rosa, Laura Rossi, Rossi Raimondo,
At the end of January 2020, the World Health Organization (WHO) declared the SARS-Cov-2 (or Coronavirus 19 [COVID-19]) infection a global health emergency [[1]Hsu L.Y. Chia P.Y. Lim J.F The novel coronavirus (SARS-CoV-2) epidemic.Ann Acad Med Singap. 2020; 49: 1-3Crossref Google Scholar]. The virus, belonging to the β-Coronaviruses, spreads mainly through the respiratory tract from person to person, using the transmembrane serine protease 2 (TMPRSS2) [[2]Matsuyama S. Nao N. Shirato K. Kawase M. Saito S. ...
Elsevier BV
Produção Nacional
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Lisa de las Fuentes, Yan V. Sun, Raymond Noordam, Thomas W. Winkler, Mary F. Feitosa, Karen Schwander, Amy R. Bentley, Michael R. Brown, Xiuqing Guo, Alisa K. Manning, Daniel I. Chasman, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Archie Campbell, Ching‐Yu Cheng, Rajkumar Dorajoo, Fernando Pires Hartwig, A.R.V.R. Horimoto, Changwei Li, Ruifang Li‐Gao, Yongmei Liu, Jonathan Marten, Solomon K. Musani, Ιωάννα Ντάλλα, Tuomo Rankinen, Melissa A. Richard, Xueling Sim, Albert V. Smith, Salman M. Tajuddin, Bamidele O. Tayo, Dina Vojinović, Helen R. Warren, Xuan Deng, Maris Alver, Mathilde Boissel, Jin Fang Chai, Xu Chen, Kaare Christensen, Jasmin Divers, Εvangelos Εvangelou, Chuan Gao, Giorgia Girotto, Sarah E. Harris, Meian He, Fang‐Chi Hsu, Brigitte Kühnel, Federica Laguzzi, Xiaoyin Li, Leo‐Pekka Lyytikäinen, Ilja M. Nolte, Alaitz Poveda, Rainer Rauramaa, Muhammad Riaz, Rico Rueedi, Xiao‐Ou Shu, Harold Snieder, Tamar Sofer, Fumihiko Takeuchi, Niek Verweij, Erin B. Ware, Stefan Weiß, Lisa R. Yanek, Najaf Amin, Dan Arking, Donna K. Arnett, Sven Bergmann, Eric Boerwinkle, Jennifer A. Brody, Ulrich Broeckel, Marco Brumat, Gregory L. Burke, Claudia P. Cabrera, Mickaël Canouil, Miao Li Chee, Yii‐Der Ida Chen, Massimiliano Cocca, John Connell, H. Janaka de Silva, Paul S. de Vries, Guðný Eiríksdóttir, Jessica D. Faul, Virginia Fisher, Terrence Forrester, Ervin F. Fox, Yechiel Friedlander, He Gao, Bruna Gigante, Franco Giulianini, C. Charles Gu, Dongfeng Gu, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew‐Kiat Heng, Steven C. Hunt, M. Arfan Ikram, Marguerite R. Irvin, Mika Kähönen, Maryam Kavousi, Chiea Chuen Khor, Tuomas O. Kilpeläinen, Woon‐Puay Koh, Pirjo Komulainen, Aldi T. Kraja, José Eduardo Krieger, Carl D. Langefeld, Yize Li, Jingjing Liang, David C. Liewald, Yongmei Liu, Jianjun Liu, Kurt K. Lohman, Reedik Mägi, Colin A. McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Dennis O. Mook‐Kanamori, Mike A. Nalls, Christopher P. Nelson, Jill M. Norris, Jeff O’Connell, Adesola Ogunniyi, Sandosh Padmanabhan, Colin N. A. Palmer, Nancy L. Pedersen, Thomas T. Perls, Annette Peters, Astrid Petersmann, Patricia A. Peyser, Ozren Polašek, David J. Porteous, Leslie J. Raffel, Treva Rice, Jerome I. Rotter, Igor Rudan, Oscar L. Rueda‐Ochoa, Charumathi Sabanayagam, B L Salako, Pamela J. Schreiner, James M. Shikany, Stephen Sidney, Mario Sims, Colleen M. Sitlani, Jennifer A. Smith, John M. Starr, Konstantin Strauch, Morris A. Swertz, Alexander Teumer, Yih‐Chung Tham, André G. Uitterlinden, Dhananjay Vaidya, M. Yldau van der Ende, Mélanie Waldenberger, Lihua Wang, Ya Xing Wang, Wenbin Wei, David R. Weir, Wanqing Wen, Jie Yao, Bing Yu, Caizheng Yu, Jian‐Min Yuan, Wei Zhao, Alan B. Zonderman, Diane M. Becker, Donald W. Bowden, Ian J. Deary, Marcus Dörr, Tõnu Esko, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Jost B. Jonas, Candace M. Kammerer, Norihiro Kato, Timo A. Lakka, Karin Leander, Terho Lehtimäki, Patrik K. E. Magnusson, Pedro Marques‐Vidal, Brenda W.J.H. Penninx, Mark M. Iles, Pim van der Harst, Lynne E. Wagenknecht, Tangchun Wu, Wei Zheng, Xiaofeng Zhu, Claude Bouchard, Stephen S. Rich, Adolfo Correa, Michele K. Evans, Vilmundur Guðnason, Caroline Hayward, Bernardo Lessa Horta, Tanika N. Kelly, Stephen B. Kritchevsky, Daniel Levy, Walter R. Palmas, Alexandre C. Pereira, Michael Province, Bruce M. Psaty, Paul M. Ridker, Charles N. Rotimi, E. Shyong Tai, Rob M. van Dam, Cornelia M. van Duijn, Tien Yin Wong, Kenneth Rice, W. James Gauderman, Alanna C. Morrison, Kari E. North, Sharon Kardia, Mark J. Caulfield, Paul Elliott, Patricia B. Munroe, Paul W. Franks, D. C. Rao, Myriam Fornage,
Tópico(s): Birth, Development, and Health
2020 - Springer Nature | Molecular Psychiatry
Produção Nacional
Revisado por pares
Riyaz Patel, Vinicius Tragante, Amand F. Schmidt, Raymond O. McCubrey, Michael V. Holmes, Laurence J Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S. Virani, Karol Kamiński, Jochen D. Muehlschlegel, Hooman Allayee, Peter Almgren, Maris Alver, E.V. Baranova, Hassan Behloui, Bram Boeckx, Peter S. Braund, Lutz Philipp Breitling, Graciela Delgado, Núbia E. Duarte, Marie‐Pierre Dubé, Line Dufresne, Niclas Eriksson, Luisa Foco, Markus Scholz, Crystel M. Gijsberts, Charlotte Glinge, Yan Gong, Jaana Hartiala, Mahyar Heydarpour, Jaroslav A. Hubáček, Marcus E. Kleber, Daniel Kofink, Salma Kotti, Pekka Kuukasjärvi, Vei-Vei Lee, Andreas Leiherer, Petra A. Lenzini, Daniel L. Levin, Leo‐Pekka Lyytikäinen, Nicola Martinelli, Ute Mons, Christopher P. Nelson, Kjell Nikus, Anna P. Pilbrow, Rafał Płoski, Yan V. Sun, Michael W.T. Tanck, W.H. Wilson Tang, Stella Trompet, Sander W. van der Laan, Jessica van Setten, Ragnar O. Vilmundarson, Chiara Viviani Anselmi, Efthymia Vlachopoulou, Lawien Al Ali, Eric Boerwinkle, Carlo Briguori, John F. Carlquist, Kathryn F. Carruthers, Gavino Casu, John Deanfield, Panos Deloukas, Frank Dudbridge, Thomas Engstrøm, Natalie Fitzpatrick, Kim Fox, Bruna Gigante, Stefan James, Marja‐Liisa Lokki, Paulo A. Lotufo, Nicola Marziliano, Ify Mordi, Joseph B Muhlestein, Christopher Newton‐Cheh, Jan Piťha, Christoph H. Saely, Ayman Samman‐Tahhan, Pratik B. Sandesara, Andrej Teren, Adam Timmis, Frans Van de Werf, Els Wauters, Arthur A.M. Wilde, Ian Ford, David J. Stott, Ale Algra, Maria Grazia Andreassi, Diego Ardissino, Benoît J. Arsenault, Christie M. Ballantyne, Thomas O. Bergmeijer, Connie R. Bezzina, Simon C. Body, Eric Boersma, Peter Bogaty, Michiel L. Bots, Hermann Brenner, Jasper J. Brugts, Ralph Burkhardt, Clara Carpeggiani, Gianluigi Condorelli, Rhonda M. Cooper‐DeHoff, Sharon Cresci, Nicolas Danchin, Ulf dé Fairé, Robert N. Doughty, Heinz Drexel, James C. Engert, Keith A.A. Fox, Domenico Girelli, Diederick E. Grobbee, Emil Hagström, Stanley L. Hazen, Claes Held, Harry Hemingway, Imo E. Hoefer, G. Kees Hovingh, Reza Jabbari, Julie A. Johnson, J. Wouter Jukema, Marcin Kaczor, Mika Kähönen, Jiří Kettner, Marek Kiliszek, Olaf H. Klungel, Bo Lagerqvist, Diether Lambrechts, Jari Laurikka, Terho Lehtimäki, Daniel Lindholm, Bakhtawar K. Mahmoodi, Anke H. Maitland‐van der Zee, Ruth McPherson, Olle Melander, Andres Metspalu, Anna Niemcunowicz‐Janica, Oliviero Olivieri, Grzegorz Opolski, Colin N. A. Palmer, Gerard Pasterkamp, Carl J. Pepine, Alexandre C. Pereira, Louise Pilote, Arshed A. Quyyumi, Mark Richards, Marek Sanak, Agneta Siegbahn, Tabassome Simon, Juha Sinisalo, J. G. Smith, John A. Spertus, Steen Stender, Alexandre F.R. Stewart, Wojciech Szczeklik, Anna Szpakowicz, Jean‐Claude Tardif, Jurriën M. ten Berg, Jacob Tfelt‐Hansen, George Thanassoulis, Joachim Thiery, Christian Torp‐Pedersen, Yolanda van der Graaf, Frank L.J. Visseren, Johannes Waltenberger, Peter Weeke, Pim van der Harst, Chim C. Lang, Naveed Sattar, Vicky A. Cameron, Jeffrey L. Anderson, James M. Brophy, Guillaume Paré, Benjamin D. Horne, Winfried März, Lars Wallentin, Nilesh J. Samani, Aroon D. Hingorani, Folkert W. Asselbergs,
Background: The Genetics of Subsequent Coronary Heart Disease (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD. Methods: The consortium currently includes 57 studies from 18 countries, recruiting 185 614 participants with either acute coronary syndrome, stable CHD, or a mixture of both at baseline. All studies collected biological samples and followed-up study participants ...
Tópico(s): Lipoproteins and Cardiovascular Health
2019 - Wolters Kluwer | Circulation Genomic and Precision Medicine
Produção Nacional
Revisado por pares
Riyaz Patel, Amand F. Schmidt, Vinicius Tragante, Raymond O. McCubrey, Michael V. Holmes, Laurence J Howe, Kenan Direk, Axel Åkerblom, Karin Leander, Salim S. Virani, Karol Kamiński, Jochen D. Muehlschlegel, Marie‐Pierre Dubé, Hooman Allayee, Peter Almgren, Maris Alver, E.V. Baranova, Hassan Behlouli, Bram Boeckx, Peter S. Braund, Lutz Philipp Breitling, Graciela Delgado, Núbia E. Duarte, Line Dufresne, Niclas Eriksson, Luisa Foco, Crystel M. Gijsberts, Yan Gong, Jaana Hartiala, Mahyar Heydarpour, Jaroslav A. Hubáček, Marcus E. Kleber, Daniel Kofink, Pekka Kuukasjärvi, Vei‐Vei Lee, Andreas Leiherer, Petra A. Lenzini, Daniel L. Levin, Leo‐Pekka Lyytikäinen, Nicola Martinelli, Ute Mons, Christopher P. Nelson, Kjell Nikus, Anna P. Pilbrow, Rafał Płoski, Yan V. Sun, Michael W.T. Tanck, W.H. Wilson Tang, Stella Trompet, Sander W. van der Laan, Jessica van Setten, Ragnar O. Vilmundarson, Chiara Viviani Anselmi, Efthymia Vlachopoulou, Eric Boerwinkle, Carlo Briguori, John F. Carlquist, Kathryn F. Carruthers, Gavino Casu, John Deanfield, Panos Deloukas, Frank Dudbridge, Natalie Fitzpatrick, Bruna Gigante, Stefan James, Marja‐Liisa Lokki, Paulo A. Lotufo, Nicola Marziliano, Ify Mordi, Joseph B. Muhlestein, Chris Newton Cheh, Jan Piťha, Christoph H. Saely, Ayman Samman‐Tahhan, Pratik B. Sandesara, Andrej Teren, Adam Timmis, Frans Van de Werf, Els Wauters, Arthur A.M. Wilde, Ian Ford, David J. Stott, Ale Algra, Maria Grazia Andreassi, Diego Ardissino, Benoît J. Arsenault, Christie M. Ballantyne, Thomas O. Bergmeijer, Connie R. Bezzina, Simon C. Body, Peter Bogaty, Gert J. de Borst, Hermann Brenner, Ralph Burkhardt, Clara Carpeggiani, Gianluigi Condorelli, Rhonda M. Cooper‐DeHoff, Sharon Cresci, Ulf dé Fairé, Robert N. Doughty, Heinz Drexel, James C. Engert, Keith A.A. Fox, Domenico Girelli, Emil Hagström, Stanley L. Hazen, Claes Held, Harry Hemingway, Imo E. Hoefer, G. Kees Hovingh, Julie A. Johnson, Pim A. de Jong, J. Wouter Jukema, Marcin Kaczor, Mika Kähönen, Jiří Kettner, Marek Kiliszek, Olaf H. Klungel, Bo Lagerqvist, Diether Lambrechts, Jari Laurikka, Terho Lehtimäki, Daniel Lindholm, Bakhtawar K. Mahmoodi, Anke H. Maitland‐van der Zee, Ruth McPherson, Olle Melander, Andres Metspalu, Witold Pepiński, Oliviero Olivieri, Grzegorz Opolski, Colin N. A. Palmer, Gerard Pasterkamp, Carl J. Pepine, Alexandre C. Pereira, Louise Pilote, Arshed A. Quyyumi, Mark Richards, Marek Sanak, Markus Scholz, Agneta Siegbahn, Juha Sinisalo, J. G. Smith, John A. Spertus, Alexandre F.R. Stewart, Wojciech Szczeklik, Anna Szpakowicz, Jurriën M. ten Berg, George Thanassoulis, Joachim Thiery, Yolanda van der Graaf, Frank L.J. Visseren, Johannes Waltenberger, Pim van der Harst, Jean‐Claude Tardif, Naveed Sattar, Chim C. Lang, Guillaume Paré, James M. Brophy, Jeffrey L. Anderson, Winfried März, Lars Wallentin, Vicky A. Cameron, Benjamin D. Horne, Nilesh J. Samani, Aroon D. Hingorani, Folkert W. Asselbergs,
Background: Genetic variation at chromosome 9p21 is a recognized risk factor for coronary heart disease (CHD). However, its effect on disease progression and subsequent events is unclear, raising questions about its value for stratification of residual risk. Methods: A variant at chromosome 9p21 (rs1333049) was tested for association with subsequent events during follow-up in 103 357 Europeans with established CHD at baseline from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) Consortium ( ...
Tópico(s): Genomic variations and chromosomal abnormalities
2019 - Wolters Kluwer | Circulation Genomic and Precision Medicine
Produção Nacional
Revisado por pares
Yan V. Sun, Lisa de las Fuentes, Thomas W. Winkler, Daniel I. Chasman, Amy R. Bentley, Aldi T. Kraja, Ιωάννα Ντάλλα, Helen R. Warren, Xiuqing Guo, Karen Schwander, Alisa K. Manning, Michael R. Brown, Hugues Aschard, Mary F. Feitosa, Nora Franceschini, Yingchang Lu, Ching‐Yu Cheng, Xueling Sim, Dina Vojinović, Jonathan Marten, Solomon K. Musani, Tuomas O. Kilpeläinen, Melissa A. Richard, Stella Aslibekyan, Traci M. Bartz, Rajkumar Dorajoo, Changwei Li, Yongmei Liu, Tuomo Rankinen, Albert V. Smith, Salman M. Tajuddin, Bamidele O. Tayo, Wei Zhao, Yanhua Zhou, Nana Matoba, Tamar Sofer, Maris Alver, Marzyeh Amini, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Ilaria Gandin, Chuan Gao, Franco Giulianini, Anuj Goel, Sarah E. Harris, Fernando Pires Hartwig, Meian He, Andréa R. V. R. Horimoto, Fang‐Chi Hsu, Anne Jackson, Candace M. Kammerer, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Karin Leander, Wen‐Jane Lee, Keng‐Hung Lin, Jian’an Luan, Leo‐Pekka Lyytikäinen, Colin A. McKenzie, Christopher P. Nelson, Raymond Noordam, Robert A. Scott, Wayne H.-H. Sheu, Alena Stančáková, Fumihiko Takeuchi, Peter J. van der Most, Tibor V. Varga, R.J. Waken, Heming Wang, Yajuan Wang, Erin B. Ware, Stefan Weiß, Wanqing Wen, Lisa R. Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Tamuno Alfred, Najaf Amin, Dan E. Arking, Tin Aung, R. Graham Barr, Lawrence F. Bielak, Eric Boerwinkle, Erwin P. Böttinger, Peter S. Braund, Jennifer A. Brody, Ulrich Broeckel, Brian E. Cade, Archie Campbell, Mickaël Canouil, Aravinda Chakravarti, Massimiliano Cocca, Francis S. Collins, John Connell, Renée de Mutsert, H Janaka de Silva, Marcus Dörr, Qing Duan, Charles B. Eaton, Georg Ehret, Εvangelos Εvangelou, Jessica D. Faul, Nita G. Forouhi, Oscar H. Franco, Yechiel Friedlander, He Gao, Bruna Gigante, C. Charles Gu, Preeti Gupta, Saskia P. Hagenaars, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew‐Kiat Heng, Albert Hofman, Barbara V. Howard, Steven C. Hunt, Marguerite R. Irvin, Yucheng Jia, Tomohiro Katsuya, Joel D. Kaufman, Nicola D. Kerrison, Chiea Chuen Khor, Woon‐Puay Koh, Heikki A. Koistinen, Charles B Kooperberg, José Eduardo Krieger, Michiaki Kubo, Zoltán Kutalik, Johanna Kuusisto, Timo A. Lakka, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Joseph H. Lee, Benjamin Lehne, Daniel Levy, Cora E. Lewis, Yize Li, Sing Hui Lim, Yongmei Liu, Jianjun Liu, Jingmin Liu, Yeheng Liu, Marie Loh, Kurt K. Lohman, Tin Louie, Reedik Mägi, Koichi Matsuda, Thomas Meitinger, Andres Metspalu, Lili Milani, Yukihide Momozawa, Thomas H. Mosley, Mike A. Nalls, Ubaydah Nasri, Jeff O’Connell, Adesola Ogunniyi, Walter R. Palmas, Colin N. A. Palmer, James S. Pankow, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Ozren Polašek, David J. Porteous, Olli T. Raitakari, Frida Renström, Treva Rice, Paul M. Ridker, Antonietta Robino, Jennifer G. Robinson, Lynda M. Rose, Igor Rudan, Charumathi Sabanayagam, Babatunde Salako, Kevin Sandow, Carsten Oliver Schmidt, Pamela J. Schreiner, William R. Scott, Peter Sever, Mario Sims, Colleen M. Sitlani, Blair H. Smith, Jennifer A. Smith, Harold Snieder, John M. Starr, Konstantin Strauch, Hua Tang, Kent D. Taylor, Yik Ying Teo, Yih‐Chung Tham, André G. Uitterlinden, Mélanie Waldenberger, Lihua Wang, Ya Xing Wang, Wen Bin Wei, Gregory Wilson, Mary K. Wojczynski, Yong‐Bing Xiang, Jie Yao, Jian‐Min Yuan, Alan B. Zonderman, Diane M. Becker, Michael Boehnke, Donald W. Bowden, John C. Chambers, Yii‐Der Ida Chen, David R. Weir, Ulf dé Fairé, Ian J. Deary, Tõnu Esko, Martin Farrall, Terrence Forrester, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo Lessa Horta, Yi‐Jen Hung, Jost B. Jonas, Norihiro Kato, Jaspal S. Kooner, Markku Laakso, Terho Lehtimäki, Kae‐Woei Liang, Patrik K. E. Magnusson, Albertine J. Oldehinkel, Alexandre C. Pereira, Thomas T. Perls, Rainer Rauramaa, Susan Redline, Rainer Rettig, Nilesh J. Samani, Berthold Lausen, Xiao‐Ou Shu, Pim van der Harst, Lynne E. Wagenknecht, Nicholas J. Wareham, Hugh Watkins, Ananda R. Wickremasinghe, Tangchun Wu, Yoichiro Kamatani, Cathy C. Laurie, Claude Bouchard, Stephen S. Rich, Michele K. Evans, Vilmundur Guðnason, James E. Hixson, Sharon L.R. Kardia, Stephen B. Kritchevsky, Bruce M. Psaty, Rob M. van Dam, Donna K. Arnett, Dennis O. Mook‐Kanamori, Myriam Fornage, Ervin R. Fox, Caroline Hayward, Cornelia M. van Duijn, E. Shyong Tai, Tien Yin Wong, Ruth J. F. Loos, Alex P. Reiner, Charles N. Rotimi, Laura J. Bierut, Xiaofeng Zhu, L. Adrienne Cupples, Michael A. Province, Jerome I. Rotter, Paul W. Franks, Kenneth Rice, Paul Elliott, Mark J. Caulfield, W. James Gauderman, Patricia B. Munroe, D. C. Rao, Alanna C. Morrison,
Abstract Elevated blood pressure (BP), a leading cause of global morbidity and mortality, is influenced by both genetic and lifestyle factors. Cigarette smoking is one such lifestyle factor. Across five ancestries, we performed a genome-wide gene–smoking interaction study of mean arterial pressure (MAP) and pulse pressure (PP) in 129 913 individuals in stage 1 and follow-up analysis in 480 178 additional individuals in stage 2. We report here 136 loci significantly associated with MAP and/or PP. Of ...
Oxford University Press | Human Molecular Genetics
Amy R. Bentley, Yan V. Sun, Michael R. Brown, Thomas W. Winkler, Aldi T. Kraja, Ιωάννα Ντάλλα, Karen Schwander, Daniel I. Chasman, Elise Lim, Xuan Deng, Xiuqing Guo, Jingmin Liu, Yingchang Lu, Ching‐Yu Cheng, Xueling Sim, Dina Vojinović, Jennifer E. Huffman, Solomon K. Musani, Changwei Li, Mary F. Feitosa, Melissa A. Richard, Raymond Noordam, Jennifer L. Baker, Guanjie Chen, Hugues Aschard, Traci M. Bartz, Jingzhong Ding, Rajkumar Dorajoo, Alisa K. Manning, Tuomo Rankinen, Albert V. Smith, Salman M. Tajuddin, Wei Zhao, Mariaelisa Graff, Maris Alver, Mathilde Boissel, Jin Fang Chai, Xu Chen, Jasmin Divers, Εvangelos Εvangelou, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E. Harris, Fernando Pires Hartwig, Meian He, A.R.V.R. Horimoto, Fang‐Chi Hsu, Yi‐Jen Hung, Anne Jackson, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Karin Leander, Keng‐Hung Lin, Jian’an Luan, Leo‐Pekka Lyytikäinen, Nana Matoba, Ilja M. Nolte, Maik Pietzner, Bram P. Prins, Muhammad Riaz, Antonietta Robino, M. Abdullah Said, Nicole Schupf, Robert A. Scott, Tamar Sofer, Alena Stančáková, Fumihiko Takeuchi, Bamidele O. Tayo, Peter J. van der Most, Tibor V. Varga, Tzung‐Dau Wang, Yajuan Wang, Erin B. Ware, Wanqing Wen, Yong‐Bing Xiang, Lisa R. Yanek, Weihua Zhang, Jing Hua Zhao, Adebowale Adeyemo, Saima Afaq, Najaf Amin, Marzyeh Amini, Dan E. Arking, Zorayr Arzumanyan, Tin Aung, Christie M. Ballantyne, R. Graham Barr, Lawrence F. Bielak, Eric Boerwinkle, Erwin P. Böttinger, Ulrich Broeckel, Morris Brown, Brian E. Cade, Archie Campbell, Mickaël Canouil, Charumathi Sabanayagam, Yii‐Der Ida Chen, Kaare Christensen, Maria Pina Concas, John Connell, Lisa de las Fuentes, H. Janaka de Silva, Paul S. de Vries, Ayo P. Doumatey, Qing Duan, Charles B. Eaton, Ruben N. Eppinga, Jessica D. Faul, James S. Floyd, Nita G. Forouhi, Terrence Forrester, Yechiel Friedlander, Ilaria Gandin, He Gao, Mohsen Ghanbari, Sina A. Gharib, Bruna Gigante, Franco Giulianini, Hans J. Grabe, C. Charles Gu, Tamara B. Harris, Sami Heikkinen, Chew‐Kiat Heng, Makoto Hirata, James E. Hixson, M. Arfan Ikram, Yucheng Jia, Roby Joehanes, Craig Johnson, Jost B. Jonas, Anne E. Justice, Tomohiro Katsuya, Chiea Chuen Khor, Tuomas O. Kilpeläinen, Woon‐Puay Koh, Ivana Kolčić, Charles Kooperberg, José Eduardo Krieger, Stephen B. Kritchevsky, Michiaki Kubo, Johanna Kuusisto, Timo A. Lakka, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Benjamin Lehne, Cora E. Lewis, Yize Li, Jingjing Liang, Shiow J. Lin, Yongmei Liu, Jianjun Liu, Kiang Liu, Marie Loh, Kurt K. Lohman, Tin Louie, Anna Luzzi, Reedik Mägi, Anubha Mahajan, Ani Manichaikul, Colin A. McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Karen L. Mohlke, Yukihide Momozawa, Andrew P. Morris, Alison D. Murray, Mike A. Nalls, Matthias Nauck, Christopher P. Nelson, Kari E. North, Jeffrey R. O’Connell, Colin N. A. Palmer, George J. Papanicolau, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Ozren Polašek, Neil Poulter, Olli T. Raitakari, Alex P. Reiner, Frida Renström, Treva Rice, Stephen S. Rich, Jennifer G. Robinson, Lynda M. Rose, Frits R. Rosendaal, Igor Rudan, Carsten Oliver Schmidt, Pamela J. Schreiner, William R. Scott, Peter S. Sever, Yuan Shi, Stephen Sidney, Mario Sims, Jennifer A. Smith, Harold Snieder, John M. Starr, Konstantin Strauch, Heather M. Stringham, Nicholas Tan, Hua Tang, Kent D. Taylor, Yik Ying Teo, Yih‐Chung Tham, Henning Tiemeier, Stephen T. Turner, André G. Uitterlinden, Diana van Heemst, Mélanie Waldenberger, Heming Wang, Lan Wang, Lihua Wang, Wen Bin Wei, Christine A. Williams, Gregory Wilson, Mary K. Wojczynski, Jie Yao, Kristin L. Young, Caizheng Yu, Jian‐Min Yuan, Jie Zhou, Alan B. Zonderman, Diane M. Becker, Michael Boehnke, Donald W. Bowden, John C. Chambers, Stephen S. Rich, Ulf dé Fairé, Ian J. Deary, Paul Elliott, Tõnu Esko, Martin Farrall, Paul W. Franks, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Bernardo Lessa Horta, Jyh‐Ming Jimmy Juang, Yoichiro Kamatani, Candace M. Kammerer, Norihiro Kato, Jaspal S. Kooner, Markku Laakso, Cathy C. Laurie, I‐Te Lee, Terho Lehtimäki, Patrik K. E. Magnusson, Albertine J. Oldehinkel, Brenda W.J.H. Penninx, Alexandre C. Pereira, Rainer Rauramaa, Susan Redline, Nilesh J. Samani, Berthold Lausen, Xiao‐Ou Shu, Pim van der Harst, Lynne E. Wagenknecht, Jun‐Sing Wang, Ya Xing Wang, Nicholas J. Wareham, Hugh Watkins, David R. Weir, Ananda R. Wickremasinghe, Tangchun Wu, Eleftheria Zeggini, Wei Zheng, Claude Bouchard, Michele K. Evans, Vilmundur Guðnason, Sharon L. R. Kardia, Yongmei Liu, Bruce M. Psaty, Paul M. Ridker, Rob M. van Dam, Dennis O. Mook‐Kanamori, Myriam Fornage, Michael A. Province, Tanika N. Kelly, Ervin R. Fox, Caroline Hayward, Cornelia M. van Duijn, E. Shyong Tai, Tien Yin Wong, Ruth J. F. Loos, Nora Franceschini, Jerome I. Rotter, Xiaofeng Zhu, Laura J. Bierut, W. James Gauderman, Kenneth Rice,
The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene–smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. ...
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