Matteo Santoni, Alessandro Conti, Francesco Massari, Giorgio Arnaldi, Roberto Iacovelli, Mimma Rizzo, Ugo De Giorgi, Laura Trementino, Giuseppe Procopio, Giampaolo Tortora, Stefano Cascinu,
Fatigue is the most common symptom associated with cancer and cancer treatment. We performed an up-to-date meta-analysis to determine the incidence and relative risk (RR) of fatigue in patients (pts) with cancer treated with sorafenib (SO), sunitinib (SU) and pazopanib (PZ). PubMed databases were searched for articles published till August 2013. Eligible studies were selected according to PRISMA statement. Summary incidence, RR and 95% confidence intervals were calculated using random-effects or fixed- ...
Tópico(s): Cancer Treatment and Pharmacology
2014 - Wiley | International Journal of Cancer
Arianna Loregian, Beatrice Mercorelli, Giulia Muratore, Elisa Sinigalia, Silvana Pagni, Serena Massari, Giorgio Gribaudo, Barbara Gatto, Manlio Palumbo, Oriana Tabarrini, Violetta Cecchetti, Giorgio Palù,
ABSTRACT WC5 is a 6-aminoquinolone that potently inhibits the replication of human cytomegalovirus (HCMV) but has no activity, or significantly less activity, against other herpesviruses. Here we investigated the nature of its specific anti-HCMV activity. Structure-activity relationship studies on a small series of analogues showed that WC5 possesses the most suitable pattern of substitutions around the quinolone scaffold to give potent and selective anti-HCMV activity. Studies performed to identify ...
Tópico(s): Herpesvirus Infections and Treatments
2010 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Vincenzo Sollazzo, Furio Pezzetti, Antônio Scarano, Adriano Piattelli, Leo Massari, Giorgio Brunelli, Francesco Carinci,
Titanium is the gold standard among materials used for prosthetic devices because of its good mechanical and chemical properties. When exposed to oxygen, titanium becomes an oxide that is biocompatible and able to induce osseointegration. There are three allotropic forms of titanium dioxide: brookite, rutile, and anatase. Anatase can be prepared as a colloidal suspension and then used to coat surfaces. Anatase coating (AC) can potentially have specific biologic effects. We test the effect of AC on ...
Tópico(s): Dental materials and restorations
2007 - Lippincott Williams & Wilkins | Journal of Craniofacial Surgery
Vincenzo Sollazzo, Furio Pezzetti, Antônio Scarano, A. Piattelli, Carlo Alberto Bignozzi, Leo Massari, Giorgio Brunelli, Francesco Carinci,
Zirconium is widely used as material for prosthetic devices because of its good mechanical and chemical properties. When exposed to oxygen, zirconium becomes zirconium oxide (ZO, chemically ZrO(2)) which is biocompatible. ZO can be also prepared as a colloidal suspension and then used to coat surfaces. Zirconium oxide coating (ZOC) can potentially have specific biologic effects.The effect of ZOC on bone throughout an in vivo study using dental implants covered with ZOC and then inserted in rabbit ...
Tópico(s): Dental Implant Techniques and Outcomes
2007 - Elsevier BV | Dental Materials
Vincenzo Sollazzo, Annalisa Palmieri, Furio Pezzetti, Carlo Alberto Bignozzi, Roberto Argazzi, Leo Massari, Giorgio Brunelli, Francesco Carinci,
Abstract Zirconium is widely used as material for prosthetic devices because its good mechanical and chemical properties. When exposed to oxygen, zirconium becomes zirconium oxide (ZrO 2 ), which is biocompatible. ZrO 2 can be also prepared as a colloidal suspension and then used to coat surfaces. Zirconium oxide coating (ZrO 2 C) can potentially have specific biologic effects, and among them is bone formation related to implant osseointegration. How this biomaterial alters osteoblast activity to promote ...
Tópico(s): Dental materials and restorations
2007 - Wiley | Journal of Biomedical Materials Research Part B Applied Biomaterials
Vincenzo Sollazzo, Annalisa Palmieri, Furio Pezzetti, Antônio Scarano, Marcella Martinelli, Luca Scapoli, Leo Massari, Giorgio Brunelli, Elisabetta Caramelli, Francesco Carinci,
Abstract Titanium is the gold standard among materials used for prosthetic devices, because of its good mechanical and chemical properties. When exposed to oxygen, titanium becomes an oxide that is biocompatible and able to induce osseointegration. Three allotropic forms of titanium dioxide exist, that is brookite, rutile, and anatase. Anatase can be prepared as a colloidal suspension and then used to coat surfaces. Anatase coating (AC) can potentially have specific biological effects. Here we are ...
Tópico(s): Corrosion Behavior and Inhibition
2007 - Wiley | Journal of Biomedical Materials Research Part B Applied Biomaterials
Raffaella Palazzo, Fabiana Spensieri, Marco Massari, Giorgio Fedele, Loredana Frasca, Stefania Carrara, Delia Goletti, Clara Maria Ausiello,
ABSTRACT Tests based on the gamma interferon (IFN-γ) assay (IGA) are used as adjunctive tools for the diagnosis of Mycobacterium tuberculosis infection. Here we compared in-house and commercial whole-blood IGAs to identify a suitable assay for the surveillance of tuberculosis in population studies. The IGAs were selected on the basis of the ease with which they are performed and because they require a small amount of a biological sample and do not require cell purification. Since a “gold standard” ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2007 - American Society for Microbiology | Clinical and Vaccine Immunology
Giulia Massari, Francesca Magnoni, Giorgio Favia, Nickolas Peradze, Paolo Veronesi, Carlo La Vecchia, Giovanni Corso,
Hereditary Diffuse Gastric Cancer (HDGC) is a complex inherited syndrome caused by CDH1 germline mutations. DGC is the hallmark cancer of this genetic predisposition, but several other cancers are associated with these CDH1 mutations. In this review, we revised all studies reporting CDH1 mutations in non-GC patients. The selected studies included: (a) families aggregating with GC and other cancers, both, and (b) families presenting only non-gastric tumors association. Among non-gastric tumors, our ...
Tópico(s): Hedgehog Signaling Pathway Studies
2021 - Multidisciplinary Digital Publishing Institute | Cancers
Gianluca Ruffato, Michele Massari, Marcello Girardi, Giorgio Parisi, M. Zontini, Filippo Romanato,
A novel optical device is designed and fabricated in order to overcome the limits of the traditional sorter based on log-pol optical transformation for the demultiplexing of optical beams carrying orbital angular momentum (OAM). The proposed configuration simplifies the alignment procedure and significantly improves the compactness and miniaturization level of the optical architecture. Since the device requires to operate beyond the paraxial approximation, a rigorous formulation of transformation ...
Tópico(s): Plant Reproductive Biology
2019 - Optica Publishing Group | Optics Express
Federico Massari, Stefano Nicoli, Giorgio Romanelli, Paolo Buracco, Eric Zini,
To evaluate predictors of survival time in dogs undergoing adrenalectomy and identify risk factors associated with adrenal gland tumor metastasis and vein thrombosis.Retrospective case series.52 dogs with primary adrenal gland tumors.Medical records were reviewed. Signalment, tumor features, and information from surgical procedures were evaluated to identify factors predictive of overall survival time, which was defined as the time from surgery until death. The association between metastasis or ...
Tópico(s): Sexual Differentiation and Disorders
2011 - American Veterinary Medical Association | Journal of the American Veterinary Medical Association
Tópico(s): Architecture and Art History Studies
1974 - College Art Association | The Art Bulletin
D Enache, Livia Ferro, Emanuela Morello, Federico Massari, Giorgio Romanelli, Stefano Nicoli, Stefano Guazzetti, Federico Porporato, Eric Zini,
Few studies have assessed predictors of outcome in dogs with thyroid tumors undergoing thyroidectomy.To estimate the survival and identify prognostic factors in dogs with thyroid tumors treated by thyroidectomy.A total of 144 client-owned dogs with thyroid neoplasia that underwent thyroidectomy.Retrospective study. Data for analysis included hospital attended and year of surgery, signalment, thyroxine concentration, thyroid tumor features (lobe involvement, size, invasiveness, histopathological type), ...
Tópico(s): Discourse Analysis and Cultural Communication
2023 - Wiley | Journal of Veterinary Internal Medicine
Salvatore Masala, Domenicantonio Tropepi, Roberto Fiori, Roberta Semprini, Alessandro Martorana, Francesco Massari, Giorgio Bernardi, Giovanni Simonetti,
Using percutaneous kyphoplasty, we treated a patient with a diagnosis of Guillain-Barré syndrome who complained of an unremitting pain in the spine, refractory to the conventional medical therapy, elicited by pressure over the spinous process, and in absence of neurologic deficits. The method provided swift midline back pain relief associated with an evident augmentation in the stability and in the vertebral body's height. The injection of polymethylmethacrylate was effective and safe, no cement ...
Tópico(s): Spine and Intervertebral Disc Pathology
2004 - Lippincott Williams & Wilkins | American Journal of Physical Medicine & Rehabilitation
Emanuela Salvatorelli, Michele De Tursi, Pierantonio Menna, Consiglia Carella, R Massari, Antonella Colasante, Stefano Iacobelli, Giorgio Minotti,
The pharmacokinetics of pegylated liposomal doxorubicin (PLD) were investigated in 17 women undergoing intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) for advanced ovarian cancer and peritoneal carcinomatosis. HIPEC was performed immediately after completing debulking surgery, which included a number of peritonectomy procedures. PLD was injected and allowed to equilibrate in peritoneal cavity filled with 4 liters of physiological solution and stabilized at 42°C; next, the outflow ...
Tópico(s): Ovarian cancer diagnosis and treatment
2012 - American Society for Pharmacology and Experimental Therapeutics | Drug Metabolism and Disposition
Matteo Santoni, Francesco Massari, Giorgio Santoni, Alessia Cimadamore, Rodolfo Montironi, Nicola Battelli,
Tópico(s): Cancer Immunotherapy and Biomarkers
2021 - Elsevier BV | European Urology
Daniele Masseroni, Stefania Camici, Alessio Cislaghi, Giorgio Vacchiano, Christian Massari, Luca Brocca,
Abstract. Determining the spatiotemporal variability in the annual streamflow volume plays a relevant role in hydrology with regard to improving and implementing sustainable and resilient policies and practices of water resource management. This study investigates annual streamflow volume trends in a newly assembled, consolidated, and validated data set of daily mean river flow records from more than 3000 stations which cover near-natural basins in more than 40 countries across Europe. Although ...
Tópico(s): Flood Risk Assessment and Management
2021 - Copernicus Publications | Hydrology and earth system sciences
Leila Bagheri, Agnese Pellati, Paola Rizzo, Giorgio Aquila, Leo Massari, Monica De Mattei, Alessia Ongaro,
Pulsed electromagnetic fields (PEMFs) have been used to treat bone diseases, particularly nonunion healing. Although it is known that PEMFs promote the osteogenic differentiation of human mesenchymal stem cells (hMSCs), to date PEMF molecular mechanisms remain not clearly elucidated. The Notch signalling is a highly conserved pathway that regulates cell fate decisions and skeletal development. The aim of this study was to investigate if the known PEMF-induced osteogenic effects may involve the modulation ...
Tópico(s): Electromagnetic Fields and Biological Effects
2017 - Wiley | Journal of Tissue Engineering and Regenerative Medicine
Laura Marconato, D. Stefanello, Paola Valenti, Ugo Bonfanti, S. Comazzi, Paola Roccabianca, M. Caniatti, Giorgio Romanelli, Federico Massari, Eric Zini,
Abstract Objective —To determine factors predicting survival in dogs with high-grade multicentric lymphoma. Design —Retrospective cohort study. Animals —127 dogs with high-grade multicentric lymphoma evaluated at 4 veterinary hospitals from 2000 to 2009. Procedures —Records were reviewed to identify dogs with completely staged high-grade multicentric lymphoma treated with chemotherapy. Data collected included signalment, history, hematologic findings, tumor characteristics, treatment, and outcome. Long- ...
Tópico(s): Cancer Genomics and Diagnostics
2011 - American Veterinary Medical Association | Journal of the American Veterinary Medical Association
Salvatore Masala, Roberto Fiori, Dario Alberto Bartolucci, Matteo Mammucari, Giorgios Angelopoulos, Francesco Massari, Giovanni Simonetti,
Joint injection is a useful tool in the diagnosis of intra-articular pathology that may improve diagnostic performance of computed tomography (CT) and magnetic resonance (MR) imaging. Historically, conventional arthrography under fluoroscopy was the first method to be used to image indirectly the intra-articular soft tissues, but with the advent of CT, CT arthrography offered better soft tissue depiction. The development of conventional MR allowed even better visualization of soft tissues, and in ...
Tópico(s): Peripheral Nerve Disorders
2010 - Thieme Medical Publishers (Germany) | Seminars in Interventional Radiology
G. Raffa, S. Maimone, Antonietta Cargnel, Teresa Santantonio, Giorgio Antonucci, Marco Massari, Monica Schiavini, Gaia Caccamo, Teresa Pollicino, Giovanni Raimondo,
Objective: Current data on the prevalence of occult hepatitis B virus (HBV) infection in HIV-positive individuals conflict. As occult HBV infection could have an impact on the outcome of liver disease in HIV-positive patients, we investigated a large number of HIV-positive/HBV-surface-antigen (HBsAg) negative subjects with hepatitis C virus (HCV) infection by using the ‘gold standard’ approach for occult HBV detection—analysis of liver DNA extracts. Methods: The presence or absence of HBV DNA was determined ...
Tópico(s): Hepatitis C virus research
2007 - Lippincott Williams & Wilkins | AIDS
Beatrice Mercorelli, Anna Luganini, Giulia Muratore, Serena Massari, Maria Elena Terlizzi, Oriana Tabarrini, Giorgio Gribaudo, Giorgio Palù, Arianna Loregian,
The human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional factor essential for viral replication. IE2 modulates both viral and host gene expression, deregulates cell cycle progression, acts as an immunomodulator, and antagonizes cellular antiviral responses. Based on these facts, IE2 has been proposed as an important target for the development of innovative antiviral approaches. We previously identified the 6-aminoquinolone WC5 as a promising inhibitor of HCMV replication, ...
Tópico(s): Herpesvirus Infections and Treatments
2014 - American Society for Microbiology | Antimicrobial Agents and Chemotherapy
Eric Zini, Silvia Nolli, Filippo Ferri, Federico Massari, Gabriele Gerardi, Stefano Nicoli, Giorgio Romanelli, Vincenzo Montinaro, D. Trez, Laura Cavicchioli, Silvia Ferro,
Pheochromocytoma is frequent in dogs and carries a guarded prognosis. Current histological criteria may not predict malignant behavior in dogs, similar to humans. In humans, characterization of tumors has been refined using the pheochromocytoma of the adrenal gland scaled score (PASS) and by immunohistochemistry. The study aim was to investigate PASS and immunohistochemical markers used in humans in 24 dogs with pheochromocytoma that underwent adrenalectomy. Dogs with pheochromocytomas were reviewed ...
Tópico(s): Pituitary Gland Disorders and Treatments
2018 - SAGE Publishing | Veterinary Pathology
Fabio Acerbi, Nicola Massari, Leonardo Gasparini, Alessandro Tomasi, N. Zorzi, Giorgio Fontana, Lorenzo Pavesi, A. Gola,
Different electronic devices nowadays exploit random number generators either to create the seed for simulations, for gaming or to encrypt the communications. Particularly for cryptography applications, there is an increasing effort to realize a truly random number generator, based not on mathematical algorithms but exploiting randomness of physical processes. Among them quantum processes, provide intrinsic unpredictability, for example exploiting the arrival time, the number or the properties of ...
Tópico(s): Quantum Computing Algorithms and Architecture
2020 - IEEE Photonics Society | IEEE Journal of Selected Topics in Quantum Electronics
Giulio Nannetti, Serena Massari, Beatrice Mercorelli, Chiara Bertagnin, Jenny Desantis, Giorgio Palù, Oriana Tabarrini, Arianna Loregian,
Influenza viruses are major respiratory pathogens responsible for both seasonal epidemics and occasional pandemics worldwide. The current available treatment options have limited efficacy and thus the development of new antivirals is highly needed. We previously reported the identification of a series of cycloheptathiophene-3-carboxamide compounds as influenza A virus inhibitors that act by targeting the protein-protein interactions between the PA-PB1 subunits of the viral polymerase. In this study, ...
Tópico(s): Viral Infections and Immunology Research
2019 - Elsevier BV | Antiviral Research
Matteo Santoni, Sergio Bracarda, Massimo Nabissi, Francesco Massari, Alessandro Conti, Emilio Bria, Giampaolo Tortora, Giorgio Santoni, Stefano Cascinu,
Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic ...
Tópico(s): Angiogenesis and VEGF in Cancer
2014 - Hindawi Publishing Corporation | BioMed Research International
Roberto Gandini, Antonio Chiaravalloti, Enrico Pampana, Francesco Massari, Daniele Morosetti, Sergio Spano, Giorgio Loreni, Giovanni Simonetti,
Intracranial atherosclerosis may be the underlying pathology in up to 15% of ischemic strokes, but may account for about 40% of strokes in some populations. After an ischemic event determined by intracranial atherosclerosis, patients have a 12% annual risk of stroke recurrence, mostly during the first year. To evaluate procedural safety, clinical outcome and restenosis rate of Wingspan stent placement. Twenty-one caucasoid patients were enrolled. Target patients were affected by high-grade, symptomatic, ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2012 - Elsevier BV | Clinical Neurology and Neurosurgery
Jenny Desantis, Giulio Nannetti, Serena Massari, Maria Letizia Barreca, Giuseppe Manfroni, Violetta Cecchetti, Giorgio Palù, Laura Goracci, Arianna Loregian, Oriana Tabarrini,
With the aim to identify small molecules able to disrupt PA-PB1 subunits interaction of influenza virus (flu) RNA-dependent RNA polymerase, and based on previous structural and computational information, in this paper we have designed and synthesized a new series of cycloheptathiophene-3-carboxamide (cHTC) derivatives. Their biological evaluation led to highlight important structural insights along with new interesting compounds, such as the 2-hydroxybenzamido derivatives 29, 31, and 32, and the 4- ...
Tópico(s): RNA and protein synthesis mechanisms
2017 - Elsevier BV | European Journal of Medicinal Chemistry
Serena Massari, Beatrice Mercorelli, Luca Sancineto, Stefano Sabatini, Violetta Cecchetti, Giorgio Gribaudo, Giorgio Palù, Christophe Pannecouque, Arianna Loregian, Oriana Tabarrini,
Abstract Although human cytomegalovirus (HCMV) infection is mostly asymptomatic for immunocompetent individuals, it remains a serious threat for those who are immunocompromised, in whom it is associated with various clinical manifestations. The therapeutic utility of the few available anti‐HCMV drugs is limited by several drawbacks, including cross‐resistance due to their common mechanism of action, i.e., inhibition of viral DNA polymerase. Therefore, compounds that target other essential viral events ...
Tópico(s): Immune Cell Function and Interaction
2013 - Wiley | ChemMedChem
Federico Massari, Sara Verganti, B Secchiero, F Orifici, U Bonfanti, Giorgio Romanelli,
Background An 11‐year‐old female German Shepherd was referred for assessment and management of a suspected liver tumour. Abdominal ultrasonography revealed abundant abdominal effusion and a right liver mass in continuity with a cystic structure. The dog had undergone splenectomy for a low‐grade lymphoma 1 year prior. Methods Serum biochemical analysis revealed only a mild increase in alanine aminotransferase. The analysis of the free abdominal fluid showed a modified transudate. Ultrasound confirmed ...
Tópico(s): Pediatric Hepatobiliary Diseases and Treatments
2012 - Wiley | Australian Veterinary Journal
Federico Massari, Vincenzo Montinaro, Paolo Buracco, Giorgio Romanelli,
Objective To describe the use of a caudal superficial epigastric flap in combination with a full‐thickness oral mucosal/submucosal graft for single‐stage reconstruction of extensive preputial defects in dogs. Materials and Methods Medical records of dogs with extensive preputial defects either of traumatic origin or derived from tumour excision were reviewed. In all dogs, the prepuce was reconstructed using a full‐thickness oral mucosal/submucosal graft combined with a caudal superficial epigastric ...
Tópico(s): Nasal Surgery and Airway Studies
2018 - Wiley | Journal of Small Animal Practice