Massimo Antonelli, Giovanna Mercurio, S. Di Nunno, G. Recchioni, Giulia DeAngelis,
AbstractAbstractIn spite of advances in critical care, nosocomial infections still have a considerable impact on Intensive Care Unit (ICU) and hospital length of stay, mortality and costs. Several authors suggest that antibiotic therapy should be instituted as soon as sepsis is suspected in critically patients. Over the last two decades the rates of occurrence for pathogens have significantly changed under selective pressure from broad-spectrum antimicrobial therapy. Shifts from predominance of Gram- ...
Tópico(s): Antibiotic Use and Resistance
2001 - Taylor & Francis | Journal of Chemotherapy
Maria Laura Bartoli, Francesco Costa, Laura Malagrinò, Dario Nieri, Sandra Antonelli, Giovanna Decusatis, Claudia De Simone, Sabrina Santerini, Silvana Cianchetti, Manuela Latorre, Barbara Vagaggini, Pierluigi Paggiaro,
Recently the definition of chronic obstructive pulmonary disease (COPD) severity, stated in 2001 by Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines and based on forced expiratory volume in 1 s (FEV1) evaluation, has been considered inadequate to recognise all the multifaceted aspects of the disease. To overcome this limitation, 2011 GOLD recommendations suggested a new approach, which stratified COPD patients in four groups of severity (A, B, C, D) according to the level of ...
Tópico(s): Neonatal Respiratory Health Research
2016 - European Respiratory Society | European Respiratory Journal
Héctor Soto Parrà, Raffaele Cavina, F Latteri, A. Sala, Mario Dambrosio, Giovanna Antonelli, Emanuela Morenghi, Marco Alloisio, G Ravasi, Armando Santoro,
The cisplatin and gemcitabine (GC) regimen is usually administered as a 4- or 3-week schedule; however, the best schedule to use is still unclear. We therefore started a randomized phase II trial to compare toxicity and dose intensity (DI) between these two GC schedules.Ninety-six patients with non-small-cell lung cancer (NSCLC) and an additional 11 patients with an advanced epithelial neoplasm [bladder (n = 5), head and neck (n = 3), cervix (n = 1), esophageal (n = 1) or unknown primary carcinoma (n = 1)] were randomized ...
Tópico(s): Cancer Treatment and Pharmacology
2002 - Elsevier BV | Annals of Oncology
Felice Vito Vitale, Stefano Rotondo, Edoardo Sessa, Alessandra Parisi, Valentina Giaimo, Alessandro D’Angelo, Giovanna Antonelli, Placido Romeo, Francesco Ferraù,
Background. Venous thromboembolism (VTE) and brain metastases (MTS) are significant clinical problems in the cancer patient population. Brain MTS and deep vein thrombosis are life-threatening conditions because of the risk of fatal endocranic hypertension and pulmonary embolism. Low molecular weight heparin (LMWH) is a major treatment for cancer patients suffering from VTE with regard to the management of the acute phase and subsequent secondary prophylaxis. Treatment with anticoagulants is feared ...
Tópico(s): Cardiac tumors and thrombi
2011 - SAGE Publishing | Journal of Oncology Pharmacy Practice
Pinuccia Valagussa, Daniela De Candis, Giovanna Antonelli, Gianni Bonadonna,
The 10-year update of the world-wide overview of breast cancer treatment (Early Breast Cancer Trialists' Collaborative Group 1992) has confirmed that adjuvant systemic therapy can alter the course of breast cancer. In women younger than 50 years of age (i.e. in premenopausal women), highly significant reductions in the annual rates of both recurrence (37%) and death (27%) are produced by adjuvant combination chemotherapy when compared with local-regional treatment alone.
Tópico(s): Cancer Risks and Factors
1996 - Springer Science+Business Media | Recent results in cancer research/Recent Results in Cancer Research
Alessia Russo, Francesco Ferraù, Giovanna Antonelli, Domenico Priolo, James A. McCubrey, Massimo Libra,
Malignant melanoma is an aggressive tumor with a poor prognosis for patients with advanced disease. Over the last decades, its incidence and mortality has increased in elderly population, impacting significantly on healthcare costs, considering the increase in average age of the world population. Older age is recognized as an independent poor prognostic factor for melanoma, but the scientific community now is wondering if elderly melanoma patients have worse outcome because they are not receiving ...
Tópico(s): Melanoma and MAPK Pathways
2014 - Taylor & Francis | Expert Review of Anticancer Therapy
Milvia Zambetti, Romano Demicheli, Daniela De Candis, Giovanna Antonelli, A. Giacobone, Monica Terenziani, Alberto Laffranchi, F Garbagnati, Salvatore Biasi, Gianni Bonadonna,
Tópico(s): Colorectal Cancer Treatments and Studies
1997 - Springer Science+Business Media | Breast Cancer Research and Treatment
C. Aschele, Domizia Debernardis, Stefania Casazza, Giovanna Antonelli, G Tunesi, Chiara Baldo, Rita Lionetto, Frank Maley, Alberto Sobrero,
PURPOSE: To determine whether immunohistochemical thymidylate synthase (TS) quantitation predicts for clinical outcome in patients with advanced colorectal cancer treated by fluorouracil (FUra)-based chemotherapy. PATIENTS AND METHODS: TS levels were measured immunohistochemically on archival specimens of colorectal cancer metastases from 48 patients homogenously treated by bolus FUra plus methotrexate alternating with continuous-infusion FUra plus leucovorin. These measurements were retrospectively ...
Tópico(s): Colorectal and Anal Carcinomas
1999 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Andrea Ardizzoni, Giovanna Antonelli, Francesco Grossi, Lucia Tixi, Mara A. Cafferata, R. Rosso,
The role of chemotherapy in the treatment of advanced non-small-cell lung cancer (NSCLC) has been a subject of debate for many years. Only recently, cisplatin-based combination chemotherapy has been demonstrated to yield a small but definite survival benefit and to improve symptoms, performance status and quality of life in a substantial proportion of advanced NSCLC patients. The cisplatin-etoposide (PE) regimen was developed in the early 1980s and has been one of the standard chemotherapy programs ...
Tópico(s): Cancer therapeutics and mechanisms
1999 - Elsevier BV | Annals of Oncology
Alessia Russo, Domenico Priolo, Giovanna Antonelli, Massimo Libra, James A. McCubrey, Francesco Ferraù,
Abstract: Non-small-cell lung cancer (NSCLC) represents about 85% of all lung cancers, and more than half of NSCLCs are diagnosed at an advanced stage. Chemotherapy has reached a plateau in the overall survival curve of about 10 months. Therefore, in last decade novel targeted approaches have been developed to extend survival of these patients, including antiangiogenic treatment. Vascular endothelial growth factor (VEGF) signaling pathway plays a dominant role in stimulating angiogenesis, which is ...
Tópico(s): Colorectal Cancer Treatments and Studies
2017 - Dove Medical Press | Lung Cancer Targets and Therapy
Giuseppe Porciello, Concetta Montagnese, Anna Crispo, Maria Grimaldi, Massimo Libra, Sara Vitale, Elvira Palumbo, Rosa Pica, Ilaria Calabrese, Serena Cubisino, Luca Falzone, Luigina Poletto, Valentina Martinuzzo, Melania Prete, Nadia Esindi, Guglielmo Thomas, Daniela Cianniello, Monica Pinto, Michelino De Laurentiis, Carmen Pacilio, Massimo Rinaldo, Massimiliano D’Aiuto, Diego Serraino, Samuele Massarut, Chiara Evangelista, Agostino Steffan, Francesca Catalano, Giuseppe Luigi Banna, Giuseppa Scandurra, Francesco Ferraù, Rosalba Rossello, Giovanna Antonelli, Gennaro Guerra, Amalia Farina, Francesco Messina, Gabriele Riccardi, Davide Gatti, David J.A. Jenkins, Anita Minopoli, Bruna Grilli, Ernesta Cavalcanti, Egidio Celentano, Gerardo Botti, Maurizio Montella, Livia S. A. Augustin,
Evidence suggests a beneficial role of the Mediterranean Diet (MedDiet) on health-related quality of life (HRQoL) in healthy subjects. HRQoL is relevant in cancer therapy and disease outcomes, therefore we investigated the association between adherence to the MedDiet and HRQoL in breast cancer survivors participating in the multicentre trial DEDiCa. Diet and HRQoL were assessed at baseline in a subgroup of 309 women enrolled within 12 months of breast cancer diagnosis without metastasis (stages I-III, ...
Tópico(s): Consumer Attitudes and Food Labeling
2020 - Public Library of Science | PLoS ONE
Concetta Montagnese, Giuseppe Porciello, Sara Vitale, Elvira Palumbo, Anna Crispo, Maria Grimaldi, Ilaria Calabrese, Rosa Pica, Melania Prete, Luca Falzone, Massimo Libra, Serena Cubisino, Luigina Poletto, Valentina Martinuzzo, Sergio Coluccia, Nadia Esindi, Flavia Nocerino, Anita Minopoli, Bruna Grilli, P.C. Fiorillo, Marco Cuomo, Ernesta Cavalcanti, Guglielmo Thomas, Daniela Cianniello, Monica Pinto, Michelino De Laurentiis, Carmen Pacilio, Massimo Rinaldo, Massimiliano D’Aiuto, Diego Serraino, Samuele Massarut, Laura Caggiari, Chiara Evangelista, Agostino Steffan, Francesca Catalano, Giuseppe Luigi Banna, Giuseppa Scandurra, Francesco Ferraù, Rosalba Rossello, Giovanna Antonelli, Gennaro Guerra, Amalia Farina, Francesco Messina, Gabriele Riccardi, Davide Gatti, David J.A. Jenkins, Egidio Celentano, Gerardo Botti, Livia S. A. Augustin,
Healthy lifestyles are associated with better health-related quality of life (HRQoL), favorable prognosis and lower mortality in breast cancer (BC) survivors. We investigated changes in HRQoL after a 12-month lifestyle modification program in 227 BC survivors participating in DEDiCa trial (Mediterranean diet, exercise, vitamin D). HRQoL was evaluated through validated questionnaires: EQ-5D-3L, EORTC-QLQ-C30 and EORTC QLQ-BR23. Baseline changes were tested using analysis of variance. Multiple regression ...
Tópico(s): Nutritional Studies and Diet
2020 - Multidisciplinary Digital Publishing Institute | Nutrients
Sandro Pignata, Giovanni Scambia, Clorinda Schettino, Laura Arenare, Carmela Pisano, Davide Lombardi, Ugo De Giorgi, Claudia Andreetta, Saverio Cinieri, Carmine De Angelis, Domenico Priolo, Cláudia Casanova, Marta Rosati, Filippo Greco, Elena Zafarana, Ilaria Schiavetto, Serafina Mammoliti, Sabrina Chiara Cecere, Vanda Salutari, Simona Scalone, Alberto Farolfi, Marilena Di Napoli, Domenica Lorusso, Piera Gargiulo, Daniela Califano, Daniela Russo, Anna Spina, Rossella De Cecio, Paolo Chiodini, Francesco Perrone, Valentina Accinno, Chiara Altavilla, Claudia Andreetta, Giovanna Antonelli, Laura Arenare, Grazia Artioli, Francesco Avola, Bonifacio Barbara, Valentina Barbato, Michele Bartoletti, Simona Bevilacqua, Roberto Bordonaro, Oriana Borghese, Gaetano Buonfanti, Daniela Califano, Floriana Camarda, Giuliana Canzanella, Maria Rita Carbone, Maria Rita Carbone, G Stella, Cláudia Casanova, Chiara Cassani, Fabrizio Castagna, Monica Cattaneo, Sabrina Chiara Cecere, Paolo Chiodini, M. Cinefra, Saverio Cinieri, Nicoletta Colombo, Serena Corsetti, Monia Dall’Agata, Maria Rosaria D’Amico, Gennaro Daniele, Carmine De Angelis, Rossella De Cecio, Ugo De Giorgi, Elvira De Marino, Giovanni De Matteis, Sabino De Placido, Gabriella Del Bene, Antonia Del Giudice, Francesca Del Monte, Michele Del Sesto, Marilena Di Napoli, Maddalena Donini, Giuliana Drudi, G Falcone, Alberto Farolfi, Adolfo Favaretto, Giulia Ferrera, Manuela Florio, Valeria Forestieri, Maria Stella Gallo, Ciro Gallo, Piera Gargiulo, Francesca Garibaldi, Fabiana Gerevini, Viola Ghizzoni, Maria Olga Giganti, Anna Gimigliano, Elena Giudice, Nicoletta Gnocchi, Adriano Gravina, Filippo Greco, Stefano Greggi, Maria Laura Iaia, Annalisa Ilardi, Gelsomina Iovine, Gabriella Ippoliti, Giulia Irollo, Ilenia Isidori, Mariateresa Lapresa, G. Lavenia, Davide Lombardi, Laura Longhitano, Domenica Lorusso, Bortot Lucia, Gabriella Luzi, Serafina Mammoliti, Sara Mariano, Valentina Marino, Giovanna Marrapese, Marilena Martino, Roberta Matocci, E. Mazzoni, Daniela Mercuri, Maria Mirto, Giovanna Mollo, A. Montinaro, Marta Moscatelli, Anna Maria Mosconi, Lucia Musacchio, Nicoletta Nanni, Pamela Natalucci, Milena S. Nicoloso, Michele Orditura, Gabriella Maria Parma, Rodolfo Passalacqua, Michela Pelone, Maria Teresa Perri, Francesco Perrone, Bruno Perrucci, Alessandra Piancastelli, Maria Carmela Piccirillo, Antonio Piccolo, Sandro Pignata, Carmela Pisano, Domenico Priolo, Stefania Rapisardi, Giorgia Ravaglia, Teresa Ribecco, Caterina Ricci, Marianna Roccio, Fiorella Romano, Marta Rosati, Daniela Russo, Vanda Salutari, Daniela Sambataro, Alfonso Savio, Ada Sbriglia, Cono Scaffa, Simona Scalone, Giovanni Scambia, Clorinda Schettino, Ilaria Schiavetto, Concetta Sergi, Francesca Sgandurra, Roberto Sorio, Anna Spina, Stefano Stabile, Gianna Tabaro, Margherita Tambaro, Stefano Tamberi, Angelica Tecchiato, Ángela Maria Trujillo, Eleonora Zaccarelli, Elena Zafarana,
Summary Background Adding immunotherapy to first-line chemotherapy might improve outcomes for patients with advanced or recurrent endometrial cancer. We aimed to compare carboplatin and paclitaxel versus avelumab plus carboplatin and paclitaxel as first-line treatment with avelumab given concurrent to chemotherapy and as maintenance after the end of chemotherapy. Methods MITO END-3 is an open-label, randomised, controlled, phase 2 trial conducted at 31 cancer institutes, hospitals, and universities in ...
Tópico(s): Colorectal and Anal Carcinomas
2023 - Elsevier BV | The Lancet Oncology
V. Pugliese, Giovanna Antonelli, Maura Vincenti, Beatrice Gatteschi,
Aim and background Pathological proof of malignant in biliary strictures is useful in the preoperative setting as it helps define therapeutic planning and prognosis, and reduces the length of the subsequent surgical intervention. However, it is difficult to obtain. The aim of this study was to evaluate the yield of histological and cytological examination of endobiliary samples obtained during endoscopic retrograde cholangiopancreatography (ERCP). Methods Endobiliary forceps biopsy and brush cytology ...
Tópico(s): Colorectal Cancer Screening and Detection
1997 - SAGE Publishing | Tumori Journal
Produção Nacional
Amanda Silva De Moraes, Amanda Marques Coelho, Daniela Flôres, Giovanna Antonelli Melo Viol, Giovanna de Carvalho Meneses Costa, Luiza Bastos Martins, Maria Eduarda Navarro Volpato, Maria Júlia Ribeiro da Costa, Vinícius Barbosa dos Santos Sales, Carmen Déa Ribeiro de Paula,
Objetivo: Avaliar a abordagem terapêutica do melasma durante a gestação. Revisão bibliográfica: a elevação de progesterona e estrogênio durante a gravidez aumenta a expressão de enzimas melanogênicas que se associam ao surgimento do melasma. Embora o melasma não possua cura, o uso de filtros solares de amplo espectro e a não exposição excessiva ao sol são importantes medidas preventivas. Durante o pré-natal, o tema costuma ser ignorado pela equipe de saúde, visto que são priorizadas outras questões ...
Tópico(s): Dermatologic Treatments and Research
2021 - Revista Eletronica Acervo Saude | Revista Eletrônica Acervo Saúde
Christian A. Di Buduo, Lindsay S. Wray, Lorenzo Tozzi, Alessandro Malara, Ying Chen, Chiara E. Ghezzi, Daniel Smoot, Carla Sfara, A. Antonelli, Elise Spedden, Giovanna Bruni, Cristian Staii, Luigi De Marco, Mauro Magnani, David L. Kaplan, Alessandra Balduini,
Key Points Natural silk protein sponge and vascular tubes reproduce human bone marrow niche environments for functional platelet generation ex vivo. Programmable bioengineered model for the investigation and therapeutic targeting of altered platelet formation.
Tópico(s): Periodontal Regeneration and Treatments
2015 - Elsevier BV | Blood
Francesca Gianno, Isabella Giovannoni, Barbara Cafferata, Francesca Diomedi‐Camassei, Simone Minasi, Sabina Barresi, Francesca Romana Buttarelli, Viola Alesi, Antonello Cardoni, Manila Antonelli, Chiara Puggioni, Giovanna Stefania Colafati, Andrea Carai, Maria Vinci, Angela Mastronuzzi, Evelina Miele, Rita Alaggio, Felice Giangaspero, Sabrina Rossi,
As a relevant element of novelty, the fifth CNS WHO Classification highlights the distinctive pathobiology underlying gliomas arising primarily in children by recognizing for the first time the families of paediatric-type diffuse gliomas, both high-grade and low-grade. This review will focus on the family of paediatric-type diffuse high-grade gliomas, which includes four tumour types: 1) Diffuse midline glioma H3 K27-altered; 2) Diffuse hemispheric glioma H3 G34-mutant; 3) Diffuse paediatric-type ...
Tópico(s): Meningioma and schwannoma management
2022 - Pacini Editore | Pathologica
Andrea Ardizzoni, Giovanna Antonelli, Sante Basso Ricci, G. Frasci, Monica Rinaldi, Luca Boni, Pierre M. Galletti, M.C. Pennucci, Andrea Antonuzzo, Adriano Gravina, Luca Galli, G. Comella, Pierfranco Conté, F. Salvati, R. Rosso,
Despite a high probability of response to first-line chemotherapy, most patients with small-cell lung cancer (SCLC) will eventually have progression of their disease because of the development of resistant disease. Second-line testing of new drugs is an accepted research strategy in SCLC. In this context, the Italian Lung Cancer Task Force (FONICAP) has tested a new synthetic bifunctional alkylating agent, Ambamustine, with preliminary evidence of activity in other solid tumors. Patients with measurable ...
Tópico(s): Lung Cancer Treatments and Mutations
2000 - Lippincott Williams & Wilkins | American Journal of Clinical Oncology
Produção Nacional
... dá-se a partir do caso da atriz Giovanna Antonelli (REsp 1698701/RJ). Os argumentos traçados pelo Superior ...
Tópico(s): Medical Malpractice and Liability Issues
2021 - | Revista da Faculdade de Direito
Giovanna Antonelli, Massimo Libra, Vincenzo Panebianco, Alessia Russo, Felice Vito Vitale, Paolo Colina, Alessandro D’Angelo, Rosalba Rossello, Francesco Ferraù,
Lung cancer is the most common cause of cancer-related mortality in men and women. Non‑small cell lung cancer (NSCLC) represents close to 90% of all lung cancers. When diagnosed, >50% of patients are >65 years old. Through an improved understanding of the molecular mechanisms involved in lung oncogenesis, molecular‑targeted approaches have become an essential element for the treatment of patients with NSCLC. As the toxicity profiles of the techniques are definitely more favorable compared with chemotherapy, ...
Tópico(s): Lung Cancer Research Studies
2015 - Spandidos Publishing | Oncology Letters
Massimo Antonelli, Giovanna Mercurio,
Open access to information in medical science and adequate reporting of clinical trials may allow investigators and editors to recognize bias in study designs and avoid unnecessary duplication of efforts. Unfortunately, most of clinical trials are very expensive and are often supported by industries that may have financial reasons to hide or partially disclose results. However, investigators and editors have a greater interest in publishing results that can immediately change clinical practice rather ...
Tópico(s): Ethics in Clinical Research
2008 - Lippincott Williams & Wilkins | Critical Care Medicine
Angela Mastronuzzi, Evelina Miele, Agnese Pò, Manila Antonelli, Francesca Romana Buttarelli, Giovanna Stefania Colafati, Francesca Del Bufalo, Roberta Faedda, Gian Paolo Spinelli, Andrea Carai, Felice Giangaspero, Alberto Gulino, Franco Locatelli, Elisabetta Ferretti,
Extraneural metastases (ENM) rarely occur in medulloblastoma (MBL) patients and only few cases of subcutaneous localizations have been described. ENM indicate an aggressive disease associated with a worse prognosis. The characterization of metastatic tumours might be useful to understand their pathogenesis and to identify the most appropriate therapeutic strategies. We present the case of a child with Large Cell Anaplastic (LC/A) MBL, who developed multiple subcutaneous metastases in the scalp area ...
Tópico(s): Brain Metastases and Treatment
2014 - BioMed Central | BMC Cancer
Raffaella Forleo, Giorgio Grani, Marco Alfò, Valentina Zilioli, Raffaele Giubbini, Maria Chiara Zatelli, Irene Gagliardi, Alessandro Piovesan, Alberto Ragni, Silvia Morelli, Efisio Puxeddu, Loredana Pagano, Maurilio Deandrea, Graziano Ceresini, Massimo Torlontano, Barbara Puligheddu, Alessandro Antonelli, Marco Centanni, Laura Fugazzola, Giovanna Spiazzi, Salvatore Monti, Ruth Rossetto, Fabio Monzani, Giovanni Tallini, Anna Crescenzi, Clotilde Sparano, Rocco Bruno, Andrea Repaci, Dario Tumino, Luciano Pezzullo, Celestino Pio Lombardi, Umberto Ferraro Petrillo, Sébastiano Filetti, Cosimo Durante, Maria Grazia Castagna,
Background: The role of minimal extrathyroidal extension (mETE) as a risk factor for persistent papillary thyroid carcinoma (PTC) is still debated. The aims of this study were to assess the clinical impact of mETE as a predictor of worse initial treatment response in PTC patients and to verify the impact of radioiodine therapy after surgery in patients with mETE. Methods: We reviewed all records in the Italian Thyroid Cancer Observatory database and selected 2237 consecutive patients with PTC who ...
Tópico(s): Thyroid and Parathyroid Surgery
2021 - Mary Ann Liebert, Inc. | Thyroid
S Barocci, Stefano Fiordoro, Gregorio Santori, Umberto Valente, Michelangela Mossa, Paola Antonelli, Giovanna Ferrara, Giuseppe Cannella, Arcangelo Nocera,
Summary Alport syndrome (AS) is a genetic disease of type IV collagen involving non‐homogeneous patterns of inheritance characterized clinically by the presence of progressive haematuric nephritis leading to end‐stage renal disease (ESRD), hearing loss and/or ophthalmologic abnormalities. The aim of this study was to investigate, in a cohort of AS patients who had undergone a kidney graft (KG) or who were still on a waiting list for a KG, (a) whether there is a correlation between AS and HLA antigen ...
Tópico(s): Neuropeptides and Animal Physiology
2004 - Wiley | European Journal of Immunogenetics
Eugenio Garofalo, Andrea Bruni, Corrado Pelaia, Giovanni Landoni, Alberto Zangrillo, Massimo Antonelli, Giorgio Conti, Daniele Guerino Biasucci, Giovanna Mercurio, Andrea Cortegiani, Antonino Giarratano, Luigi Vetrugno, Tiziana Bove, Francesco Forfori, Francesco Corradi, Rosanna Vaschetto, Gianmaria Cammarota, Marinella Astuto, Paolo Murabito, Valentina Bellini, Massimo Zambon, Federico Longhini, Paolo Navalesi, Elena Bignami,
Abstract Background This study aims to ascertain whether (1) an educational program is sufficient to achieve adequate Diaphragm Ultrasound (DUS) assessments on healthy volunteers and (2) combining a video tutorial with a practical session is more effective in making learners capable to obtain accurate DUS measurements, as opposed to sole video tutorial. Results We enrolledstep 1: 172 volunteers naïve to ultrasound. After watching a video tutorial, a questionnaire was administered and considered to ...
Tópico(s): Phonocardiography and Auscultation Techniques
2019 - Springer Nature | The Ultrasound Journal
Maria Giovanna Danieli, Eleonora Antonelli, Mario Andrea Piga, Maria Francesca Cozzi, Alessandro Allegra, Sebastiano Gangemi,
We investigated the relationship between oxidative stress and inflammatory myopathies. We searched in the current literature the role of mitochondria and respiratory chain defects as sources of oxidative stress and reactive oxygen species production that led to muscle weakness and fatigue. Different molecules and pathways contribute to redox milieu, reactive oxygen species generation, accumulation of misfolded and carbonylated proteins that lose their ability to fulfil cellular activities. Small ...
Tópico(s): Fibromyalgia and Chronic Fatigue Syndrome Research
2023 - Elsevier BV | Autoimmunity Reviews
Alessandro Ficarra, Domenico Pietro Lo Fiego, Giovanna Minelli, Andrea Antonelli,
Narrow-bore GC columns have led to the resolution of complex matrices in a few minutes. To set up a method able to cope with the velocity of ultra fast gas-chromatographic separation, a comparison among four of the most popular lipid transmethylation was applied to pork fat. Different catalysts for transmethylation were tested (NaOCH3, BF3, H2SO4, and KOH), and were compared for yield and rate of transmethylation, cost, and safety. In all cases, KOH gave the best performance of all the considered ...
Tópico(s): Lipid metabolism and biosynthesis
2010 - Elsevier BV | Food Chemistry
Nicola Ray, Janis M. Miyasaki, Mateusz Zurowski, Ji Hyun Ko, Sang Soo Cho, Giovanna Pellecchia, Francesca Antonelli, Sylvain Houle, Anthony E. Lang, Antonio P. Strafella,
Impulse control disorders such as pathological gambling (PG) are a serious and common adverse effect of dopamine (DA) replacement medication in Parkinson's disease (PD). Patients with PG have increased impulsivity and abnormalities in striatal DA, in common with behavioural and substance addictions in the non-PD population. To date, no studies have investigated the role of extrastriatal dopaminergic abnormalities in PD patients with PG. We used the PET radiotracer, [11C] FLB-457, with high-affinity ...
Tópico(s): Obsessive-Compulsive Spectrum Disorders
2012 - Elsevier BV | Neurobiology of Disease
Lara Maritan, Giovanna Ganzarolli, Fabrizio Antonelli, Manuel Rigo, Angeliki Kapatza, Katalin Bajnok, Chiara Coletti, Claudio Mazzoli, Lorenzo Lazzarini, Paolo Vedovetto, Alexandra Chavarría Arnau,
The addition of temper in the pottery manufacturing process is attested since Prehistoric Times and is still a production choice adopted in the ceramic industry. When the temper is composed of minerals and rocks which outcrop in regions distant from each other, new questions about the production technology arise. Such situations can be explained by considering the recycling of imported rocks, including those used for architectonic elements or sculptures, mainly coming from contemporary or earlier ...
Tópico(s): Conservation Techniques and Studies
2021 - Elsevier BV | Journal of Archaeological Science
Maria Giovanna Danieli, Eleonora Antonelli, Mario Andrea Piga, Ilaria Claudi, Davide Palmeri, Alessandro Tonacci, Alessandro Allegra, Sebastiano Gangemi,
Alarmins are endogenous, constitutively expressed, chemotacting and immune activating proteins or peptides released because of non-programmed cell death (i.e. infections, trauma, etc). They are considered endogenous damage-associated molecular patterns (DAMPs), able to induce a sterile inflammation. In the last years, several studies highlighted a possible role of different alarmins in the pathogenesis of various autoimmune and immune-mediated diseases. We reviewed the relevant literature about this ...
Tópico(s): Cytokine Signaling Pathways and Interactions
2022 - Elsevier BV | Autoimmunity Reviews