Valentina Carito, Giovanni Parlapiano, Debora Rasio, Roberto Paparella, Valentina Paolucci, Giampiero Ferraguti, Antonio Greco, Massimo Ralli, Simona Pichini, Marco Fiore, Giovanna Coriale, Mauro Ceccanti, Luigi Tarani,
Fetal alcohol syndrome (FAS) is a complex and malformative condition due to the teratogenic effect of alcohol consumed during pregnancy. Several epidemiological studies have shown that maternal alcohol use during pregnancy is the most common preventable cause of mental retardation in childhood. The effects of alcohol on the fetus range from abortion to a spectrum of clinical manifestations called Fetal Alcohol Spectrum Disorders (FASD) that includes partial FAS (PFAS), neonatal Alcohol Related Birth ...
Tópico(s): Alcoholism and Thiamine Deficiency
2018 - | Biomedical Reviews
Marco Fiore, Carla Petrella, Giovanna Coriale, Pamela Rosso, Elena Fico, Massimo Ralli, Antonio Greco, Marco de Vincentiis, Antonio Minni, Antonella Polimeni, Mario Vitali, Marisa Patrizia Messina, Giampiero Ferraguti, Francesca Tarani, Simone De Persis, Mauro Ceccanti, Luigi Tarani,
Fetal Alcohol Spectrum Disorders (FASD) are the manifestation of the damage caused by alcohol consumption during pregnancy. Children with Fetal Alcohol Syndrome (FAS), the extreme FASD manifestation, show both facial dysmorphology and mental retardation. Alcohol consumed during gestational age prejudices brain development by reducing, among others, the synthesis and release of neurotrophic factors and neuroinflammatory markers. Alcohol drinking also induces oxidative stress.The present study aimed ...
Tópico(s): Heme Oxygenase-1 and Carbon Monoxide
2021 - Bentham Science Publishers | CNS & Neurological Disorders - Drug Targets
Francesca Gabanella, Andrea Colizza, Maria Chiara Mottola, Silvia Francati, Giovanna Blaconà, Carla Petrella, Christian Barbato, Antonio Greco, Massimo Ralli, Marco Fiore, Nicoletta Corbi, Giampiero Ferraguti, Alessandro Corsi, Antonio Minni, Marco de Vincentiis, Claudio Passananti, Maria Grazia Di Certo,
Head and neck squamous cell carcinoma (HNSCC) arises from the mucosal epithelium in the oral cavity, pharynx, sino-nasal region, and larynx. Laryngeal squamous cell carcinoma (LSCC) represents one-third of all head and neck cancers. Dysregulated RNA-related pathways define an important molecular signature in this aggressive carcinoma. The Survival Motor Neuron (SMN) protein regulates fundamental aspects of the RNA metabolism but, curiously, its role in cancer is virtually unknown. For the first time, ...
Tópico(s): RNA modifications and cancer
2023 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Giampiero Ferraguti, Francesca Fanfarillo, Luigi Tarani, Giovanna Blaconà, Francesca Tarani, Christian Barbato, Antonio Minni, Massimo Ralli, Silvia Francati, Antonio Greco, Carla Petrella, Marco Fiore,
Infertility is a worldwide health issue defined by the World Health Organization (WHO) as the inability to establish a pregnancy after 12 months or more of regular and unprotected sexual intercourse. Male infertility etiology can be related to either congenital or acquired factors. The therapeutical approach to male infertility depends on the underlying causes and includes medical and surgical treatments. In recent studies, the potential role of nerve growth factor (NGF) in male reproductive physiology ...
Tópico(s): Nerve injury and regeneration
2022 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences
Giannicola Iannella, Jérôme R. Lechien, Tiziano Perrone, Giuseppe Meccariello, Giovanni Cammaroto, Angelo Cannavicci, Luca Burgio, Antonino Maniaci, Salvatore Cocuzza, Milena Di Luca, Giovanna Stilo, Andrea De Vito, Giuseppe Magliulo, Antonio Greco, Marco de Vincentiis, Massimo Ralli, Stefano Pelucchi, Andrea Ciorba, Claudio Vicini,
In this paper, we perform a systematic review that discusses the state of the art and evolution on the barbed reposition pharyngoplasty (BRP) in the velo-pharyngeal surgery. Clinical evidence and published outcomes of this surgical technique are reported and discussed.We performed a systematic review of the current literature through the analysis of the last 10 years of literature on barbed palate surgery. Study design, number of patients enrolled, inclusion criteria, pre- and posttreatment outcomes ( ...
Tópico(s): Tracheal and airway disorders
2021 - Elsevier BV | American Journal of Otolaryngology
Massimo Fusconi, Armando De Virgilio, Michela Conte, Maria Giovanna Colicchio, Andrea Gallo, Antonio Greco, Giovanni Ralli, Marco de Vincentiis,
Objective The aim of this study is to evaluate the sensitivity parameters of the percentage of time the pH is <4 and >7, as well as the total number of laryngopharyngeal reflux episodes in 24 hours, in patients with suspected laryngopharyngeal reflux disease. Study Design Retrospective controlled study. Setting University hospital. Subjects and Methods The study was conducted on 46 patients with laryngopharyngeal reflux disease and 58 healthy controls. Patients and controls underwent 24 hours of dual‐ ...
Tópico(s): Gastroesophageal reflux and treatments
2012 - Wiley | Otolaryngology
Marco Fiore, Sergio Terracina, Giampiero Ferraguti, Carla Petrella, Sabina Maria Bruno, Giovanna Blaconà, Maria Grazia Di Certo, Antonio Minni, Antonio Greco, Angela Musacchio, Massimo Ralli, Luigi Tarani, Mauro Ceccanti, Antonella Polimeni, Viviana Triaca,
Evidence shows that there is a synergistic, bidirectional association between cancer and aging with many shared traits. Age itself is a risk factor for the onset of most cancers, while evidence suggests that cancer and its treatments might accelerate aging by causing genotoxic and cytotoxic insults. Aging has been associated with a series of alterations that can be linked to cancer: i) genomic instability caused by DNA damage or epigenetic alterations coupled with repair errors, which lead to progressive ...
Tópico(s): Autophagy in Disease and Therapy
2022 - Bentham Science Publishers | Current Cancer Drug Targets