Orazio Gabrielli, Stefano Bruni, Barbara Bruschi, Ines Carloni, Giovanni V. Coppa,
Gabrielli, Orazioa; Bruni, Stefanoa; Bruschi, Barbaraa; Carloni, Inesa; Coppa, Giovanni Valentinoa Author Information
Tópico(s): Genetics and Neurodevelopmental Disorders
2002 - Lippincott Williams & Wilkins | Clinical Dysmorphology
G. Coppa, Giovanni Lapenta, Piero Ravetto,
The introductory part of this work analyzes the possibility of reducing ray effects deeply rooted with the angular discretization techniques adopted to solve the neutron transport equation, by the use of angular finite elements. Such reduction can be foreseen on pure physical grounds, considering the diffusive wave form assumed by the equations of the discrete model. A larger effort is then devoted to 2D problems, for which it is shown that, in general, it is possible to cast the finite element ...
Tópico(s): Nuclear and radioactivity studies
1990 - Elsevier BV | Annals of Nuclear Energy
G. Coppa, Giovanni Lapenta, G. Dellapiana, F. Donato, V. Riccardo,
A new approach to particle in cell simulation is presented for collisionless plasmas. The new method is based on computational particles of variable size (blobs). Each blob represents an element of phase space and its shape and size are evolved in time to represent better the correct evolution. The blob particles can be split to increase the accuracy in selected regions of stronger gradients. Blobs can also be coalesced to keep the total number of blobs constant. The performance of the blob method ...
Tópico(s): Magnetic confinement fusion research
1996 - Elsevier BV | Journal of Computational Physics
Orazio Gabrielli, U. Salvolini, Giovanni V. Coppa, Pierluigi Giorgi,
... ItalySearch for more papers by this authorGiovanni V. Coppa, Corresponding Author Giovanni V. Coppa Department of Pediatrics University of Ancona ... ItalySearch for more papers by this authorGiovanni V. Coppa, Corresponding Author Giovanni V. Coppa Department of Pediatrics University of Ancona 60100 Ancona ...
Tópico(s): Congenital Ear and Nasal Anomalies
1995 - Wiley | Clinical Genetics
Stefania Coppa, Giovanni Quattrocchi, Andrea Cucco, Giuseppe Andrea de Lucia, Sara Vencato, Andrea Camedda, Paolo Domenici, Alessandro Conforti, Andrea Satta, Renato Tonielli, Monica Bressan, Giorgio Massaro, Giovanni De Falco,
Abstract Striped seagrass meadows are formed by narrow ribbons which are elevated over the seabed and separated by channels. Limited information on the genesis and development of this morphological pattern, including the adaptive responses of associated biota, is preventing holistic insight into the functioning of such protected ecosystems. This paper assessed the structural dynamics of a Posidonia oceanica striped meadow and the distribution and 3D orientation of the associated bivalve Pinna nobilis . ...
Tópico(s): Coastal wetland ecosystem dynamics
2019 - Nature Portfolio | Scientific Reports
M. Artiglia, P. Di Vita, M. Potenza, G. Coppa, Giovanni Lapenta, Piero Ravetto,
A new discretisation procedure based on a finite difference approach is presented for the analysis of arbitrary two-dimensional optical dielectric waveguides. It is based on a longitudinally variant discretisation grid that allows an accurate treatment of waveguide changes of geometry to be obtained. Comparisons with the well known beam propagation method show a strong improvement in accuracy and computational time saving.
Tópico(s): Microwave Engineering and Waveguides
1991 - Institution of Engineering and Technology | Electronics Letters
Antonio Cao, S. De Virgiliis, C Lippi, Giovanni V. Coppa,
Muscle and serum CPK electrophoretic pattern and serum GOT electrophoretic pattern were studied in Duchenne type, limb-girdle type and distal congenital type muscular dystro- phies. Muscle CPK isoenzyme pattern usually did not show significant changes. In 2 cases a fetal-like pattern was observed. Serum CPK isoenzyme pattern showed in some cases only the MM type. In other cases MB type was found in addition to MM type. Serum electrophoresis zone of GOT displayed in some cases only the cytoplasmic ...
Tópico(s): Nuclear Structure and Function
1971 - Karger Publishers | Enzyme
Giovanni V. Coppa, P. L. Giorgi, L. Felici, Orazio Gabrielli, Emilio Donti, Sergio Bernasconi, Hans Kresse, Eduard Paschke, C Mastropaolo,
Tópico(s): Trypanosoma species research and implications
1983 - Springer Science+Business Media | European Journal of Pediatrics
Orazio Gabrielli, U. Salvolini, Giovanni V. Coppa, Carlo Catassi, R Rossi, Antonio Manca, R. Lanza, P. L. Giorgi,
Tópico(s): Pediatric Urology and Nephrology Studies
1990 - Springer Science+Business Media | Pediatric Radiology
P. L. Giorgi, Orazio Gabrielli, V. Bonifazi, Carlo Catassi, Giovanni V. Coppa,
Abstract Jeune syndrome is characterized by respiratory distress, osseous dysplasia, and short stature. Patients generally die during the first months of life. However, some cases with milder clinical manifestations have been described; these cases show characteristic renal involvement of different severity. The authors report on two cases of the mild form of Jeune syndrome in sisters.
Tópico(s): Autoimmune and Inflammatory Disorders
1990 - Wiley | American Journal of Medical Genetics
Carlo Catassi, Elia Cardinali, G. D’Angelo, Giovanni V. Coppa, P. L. Giorgi,
Several studies have shown that the determination of fecal az-antitrypsin is a valuable indicator of intestinal protein loss. l Compared with conventional techniques for the diagnosis of protein-losing enteropathy, such as the 5tCrlabeled albumin excretion test, the measurement of FA1-AT has the advantage of being safe, nonisotopic, and easily done. Until now, most authors have determined FA-1-AT on lyophilized stools following the technique described by Crossley and Elliot. 2 We evaluated the validity ...
Tópico(s): Streptococcal Infections and Treatments
1986 - Elsevier BV | The Journal of Pediatrics
G Panin, S Naia, Roberto Dall’Amico, Lino Chiandetti, F Zachello, Carlo Catassi, L. Felici, Giovanni V. Coppa,
We describe a simple, rapid, precise, and sensitive spectrophotometric method for measuring urinary glycosaminoglycan (GAG) sulfate excretion. The GAG sulfates are precipitated with cetylpyridinium chloride, resuspended in water, and mixed with the basic dye 1,9-dimethylmethylene blue to produce a complex with the polyanionic molecule of sulfated GAGs. Absorbance is read at 535 nm. The standard curve for reaction was linear up to 12 micrograms of the different GAGs: dermatan sulfate, heparan sulfate, ...
Tópico(s): Hemostasis and retained surgical items
1986 - American Association for Clinical Chemistry | Clinical Chemistry
Carlo Catassi, Rita Mirakian, G Natalini, Andrea Sbarbati, Saverio Cinti, Giovanni V. Coppa, P. L. Giorgi,
Summary: A 13-year-old boy with common variable hypogammaglobulinemia and type I diabetes developed a severe enteropathy that proved to be unresponsive to any treatment, including total parenteral nutrition. No evidence of known etiologies of malabsorption and/or secretory diarrhea was found in this subject. A high titer of complement-fixing enterocyte autoantibody was persistently found in the patient's serum. These features suggest that the enteropathy of this primarily immunodeficient subject ...
Tópico(s): Celiac Disease Research and Management
1988 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition
Andrea Ballabio, Giancarlo Parenti, Rosalba Carrozzo, Giovanni V. Coppa, L. Felici, Valeria Migliori, Margherita Silengo, P Franceschini, Generoso Andria,
We describe a family with two male members showing an X/Y translocation (karyotype: 46, Y, der(X)t(X;Y)(p22;q11)). At physical examination both patients showed ichthyosis, mental retardation and dysmorphic features. Chondrodysplasia punctata and short stature were present in one case. Direct DNA analysis, using a steroid sulphatase cDNA probe, was performed in one patient, his mother and sister, both carriers of the translocation. We found that the translocated region of the Y chromosome includes ...
Tópico(s): interferon and immune responses
1988 - Wiley | Clinical Genetics
Rolando Cimaz, Giovanni V. Coppa, Isabelle Koné‐Paut, Bianca Link, Gregory M. Pastores, Maria Rua Elorduy, Charles H. Spencer, Carter Thorne, Nico Wulffraat, Bernhard Manger,
Undiagnosed patients with the attenuated form of mucopolysaccharidosis (MPS) type I often have joint symptoms in childhood that prompt referral to a rheumatologist. A survey conducted by Genzyme Corporation of 60 European and Canadian rheumatologists and pediatric rheumatologists demonstrated that < 20% recognized signs and symptoms of MPS I or could identify appropriate diagnosis tests. These results prompted formation of an international working group of rheumatologists, pediatric rheumatologists, ...
Tópico(s): Autoimmune and Inflammatory Disorders Research
2009 - BioMed Central | Pediatric Rheumatology
Orazio Gabrielli, Lorne A. Clarke, Stefano Bruni, Giovanni V. Coppa,
Mucopolysaccharidosis type I (MPS I) is a progressive and multisystemic disease, even in its attenuated Hurler-Scheie and Scheie forms. Clinical trials of enzyme-replacement therapy in MPS I have shown clinical benefit in patients with considerable preexisting disease, but no data exist on the effect of beginning enzyme replacement before the onset of significant clinical signs of disease. Here we present the 5-year follow-up of a boy with attenuated MPS I who had laronidase therapy initiated at ...
Tópico(s): Glycogen Storage Diseases and Myoclonus
2009 - American Academy of Pediatrics | PEDIATRICS
Orazio Gabrielli, Carlo Catassi, A. Carlucci, Giovanni V. Coppa, Pierluigi Giorgi,
Abstract We report on a male with intestinal lymphangiectasia, mild mental retardation, seizures, and a typical face; the syndrome was first delineated by Hennekam et al., Am. J. Med. Genet. 34:593‐600 [1989]. His parents are consanguineous. This case seems to confirm the existence of the Hennekam syndrome.
Tópico(s): Cystic Fibrosis Research Advances
1991 - Wiley | American Journal of Medical Genetics
P. L. Giorgi, N Oggiano, Pier Carlo Braga, Carlo Catassi, Orazio Gabrielli, Giovanni V. Coppa, Ahmad Kantar,
Abstract We investigated the ultrastructure of nasal cilia in 27 children suffering from recurrent infections of the upper respiratory tract, during and after the onset of an acute respiratory infection, and after a convalescent period of 12 weeks. Our results demonstrated that in seven subjects after resolution of infection, the morphology of a large proportion of the cilia (32%) was not back to normal. These findings suggest a long‐term residual effect of infection, or the inability to reestablish ...
Tópico(s): Respiratory viral infections research
1992 - Wiley | Pediatric Pulmonology
Orazio Gabrielli, U. Salvolini, M. Maricotti, Milena Mariani, Giovanni V. Coppa, P. L. Giorgi,
Tópico(s): Glycogen Storage Diseases and Myoclonus
1992 - Springer Science+Business Media | Neuroradiology
Rahzi El Asmar, Pinaki Panigrahi, Penelope Bamford, Irene Berti, Tarcisio Not, Giovanni V. Coppa, Carlo Catassi, Alessio Fasano,
An erratum has been written for this article. It can be viewed at Gastroenterology 2003;124:275.Background & Aims: Enteric infections have been implicated in the pathogenesis of both food intolerance and autoimmune diseases secondary to the impairment of the intestinal barrier. On the basis of our recent discovery of zonulin, a modulator of small-intestinal tight junctions, we asked whether microorganisms might induce zonulin secretion and increased small-intestinal permeability. Methods: Both ex ...
Tópico(s): Barrier Structure and Function Studies
2002 - Elsevier BV | Gastroenterology
Orazio Gabrielli, Gabriele Polonara, Luana Regnicolo, Valeria Petroni, Tommaso Scarabino, Giovanni V. Coppa, U. Salvolini,
Mucopolysaccharidoses (MPSs) are a group of inherited disorders due to lysosomal enzyme deficiencies which lead to multi-organ accumulation of glycosaminoglycans. Some forms of MPS disorders are characterized by various degrees of mental retardation. Magnetic Resonance Imaging (MRI) is the primary imaging technique to detect CNS alterations. The aim of this study is to evaluate the correlation between white matter (WM) alterations and the presence of mental retardation. We analyzed 20 patients with ...
Tópico(s): Cerebral Palsy and Movement Disorders
2003 - Wiley | American Journal of Medical Genetics Part A
Carlo Catassi, I M Rätsch, E Fabiani, Michele Rossini, Giovanni V. Coppa, P. L. Giorgi, F Bordicchia, F Candela,
Tópico(s): Eosinophilic Esophagitis
1994 - Elsevier BV | The Lancet
Orazio Gabrielli, Anna Ficcadenti, G Fabrizzi, Paolo Perri, A. Mercuri, Giovanni V. Coppa, Pierluigi Giorgi,
Abstract We report on a male infant with oral, facial, digital, and skeletal anomalies in association with severe psychomotor delay. This may represent a new oral‐facial‐digital syndrome. © 1994 Wiley‐Liss, Inc.
Tópico(s): Urological Disorders and Treatments
1994 - Wiley | American Journal of Medical Genetics
Enrico Bertino, Giovanni V. Coppa, Francesca Giuliani, Alessandra Coscia, Orazio Gabrielli, Giuseppe Sabatino, M. Sgarrella, Tiziana Testa, Lucia Zampini, C Fabris,
The benefits of human milk have been confirmed for preterm infants, due to its nutritional aspects and to its biologically active compounds. Oligosaccharides play an emerging leading role among these compounds. Mother's milk can sometimes be lacking for preterm infants; pasteurized donor milk represents therefore an important alternative. The aim of this study is to evaluate the effects of Holder pasteurization on the concentration and pattern of oligosaccharides in preterm human milk. Our results ...
Tópico(s): Breastfeeding Practices and Influences
2008 - SAGE Publishing | International Journal of Immunopathology and Pharmacology
Giovanni V. Coppa, Orazio Gabrielli, Dania Buzzega, Lucia Zampini, Tiziana Galeazzi, Francesca Maccari, Enrico Bertino, Nicola Volpi,
To date, there is no complete structural characterization of human milk glycosaminoglycans (GAGs) available nor do any data exist on their composition in bovine milk. Total GAGs were determined on extracts from human and bovine milk. Samples were subjected to digestion with specific enzymes, treated with nitrous acid, and analyzed by agarose-gel electrophoresis and high-performance liquid chromatography for their structural characterization. Quantitative analyses yielded ∼7 times more GAGs in human ...
Tópico(s): Neonatal Respiratory Health Research
2010 - Oxford University Press | Glycobiology
Orazio Gabrielli, Lucia Zampini, Tiziana Galeazzi, Lucia Padella, Lucia Santoro, Chiara Peila, Francesca Giuliani, Enrico Bertino, C Fabris, Giovanni V. Coppa,
Oligosaccharides represent one of the main components of human milk, and they have been assigned important biological functions for newborns. Qualitatively and quantitatively, their presence in milk is strictly related to the expression of the mother's Se and/or Le genes, on the basis of which 4 different milk groups have been described. The aim of the study was to provide new data on the oligosaccharide composition of preterm milk in relation to the 4 groups.High-pH anion-exchange chromatography ...
Tópico(s): Neonatal Respiratory Health Research
2011 - American Academy of Pediatrics | PEDIATRICS
Giovanni V. Coppa, Orazio Gabrielli, Lucia Zampini, Tiziana Galeazzi, Francesca Maccari, Dania Buzzega, Fabio Galeotti, Enrico Bertino, Nicola Volpi,
In a recent study, we performed a complete structural characterization of glycosaminoglycans (GAGs) in human mature milk. However, no data are available on the total content of GAGs in human milk from healthy mothers having delivered term or preterm newborns.In this study, we evaluated the total content of GAGs in pooled milk from healthy mothers having delivered term or preterm newborns during the first month of lactation.Highly specific and sensitive analytical approaches were used to quantify ...
Tópico(s): Neonatal Respiratory Health Research
2011 - Karger Publishers | Neonatology
Giovanni V. Coppa, Orazio Gabrielli, Lucia Zampini, Tiziana Galeazzi, Anna Ficcadenti, Lucia Padella, Lucia Santoro, Sara Soldi, Antonio Carlucci, Enrico Bertino, Lorenzo Morelli,
The aim of this study was to identify a link between the total amount of breast milk oligosaccharides and faecal microbiota composition of newborns at the end of the first month of life, with special attention paid to bifidobacteria, and establish the role, if any, of the different oligosaccharides in determining the gut microbiota composition.Milk oligosaccharide groups were identified by high-performance anion exchange chromatography analysis. DPCRNA from newborns' faecal samples at 30 days of ...
Tópico(s): Digestive system and related health
2011 - Lippincott Williams & Wilkins | Journal of Pediatric Gastroenterology and Nutrition
Giovanni V. Coppa, Lucia Zampini, Tiziana Galeazzi, Bruna Facinelli, Luigi Ferrante, Roberta Capretti, Orazio Gabrielli,
Breast-fed children, compared with the bottle-fed ones, have a lower incidence of acute gastroenteritis due to the presence of several antiinfective factors in human milk. The aim of this work is to study the ability of human milk oligosaccharides to prevent infections related to some common pathogenic bacteria. Oligosaccharides of human milk were fractionated by gel-filtration and characterized by thin-layer chromatography and high-performance anion exchange chromatography. Fractions obtained contained, ...
Tópico(s): Viral gastroenteritis research and epidemiology
2006 - Springer Nature | Pediatric Research
Giovanni V. Coppa, Lucia Zampini, Tiziana Galeazzi, Orazio Gabrielli,
Abstract The microbic colonization of human intestine begins at birth, when from a sterile state the newborn is exposed to an external environment rich in various bacterial species. The kind of delivery has an important influence on the composition of the intestinal flora in the first days of life. Thereafter, the microflora is mainly influenced by the kind of feeding: breast-fed infants show a predominance of bifidobacteria and lactobacilli, whereas bottle-fed infants develop a mixed flora with a lower ...
Tópico(s): Probiotics and Fermented Foods
2006 - Elsevier BV | Digestive and Liver Disease