Alfredo Tartarone, Rosa Lerose, Raffaele Ardito, Laura Troiani, Beatrice Tedesco, Giovanni Bozza, Rodolfo Cangiano, Michele Aieta,
Small cell lung cancer (SCLC) represents approximately 13% of all newly diagnosed lung cancers. SCLC is a very aggressive disease characterized by early locoregional and distant metastases. The median survival is 14–16 months for patients with limited disease and 8–11 months for those with extensive disease, with 20–40% of patients with limited disease and 5% of patients with extensive disease alive at 2 years. This report discusses the case of a long-term SCLC survivor treated with radiotherapy, ...
Tópico(s): Lung Cancer Treatments and Mutations
2014 - Future Medicine | Future Oncology
Alice Chiarici, Elisa Andrenelli, Oletta Serpilli, Matteo Andreolini, Silvia Tedesco, Giovanni Pomponio, Maria Mattea Gallo, Claudio Martini, Roberto Papa, Michela Coccia, Maria Gabriella Ceravolo,
Objective To investigate the effectiveness, feasibility, and safety of an evidence-based rehabilitation care pathway in the intensive care unit (ICU) in different patient populations. Design Observational prospective cohort study, with retrospective controls. Setting ICUs of a university hospital. Participants Patients admitted between April 1, 2015, and June 30, 2015, were compared to a retrospective cohort admitted to the same ICUs during the same 3-month period in 2014. The number of patients ...
Tópico(s): Family and Patient Care in Intensive Care Units
2019 - Elsevier BV | Archives of Physical Medicine and Rehabilitation
Rossella Panarese, Perla Tedesco, Giovanni Chimienti, Maria Stefanía Latrofa, Francesco Quaglio, Giuseppe Passantino, Canio Buonavoglia, Andrea Gustinelli, Angelo Tursi, Domenico Otranto,
The fan mussel, Pinna nobilis (Linnaeus 1758), is an endemic bivalve of the Mediterranean basin, protected by international legislation as an endangered species. In the early summer of 2018, a mass mortality event (MME) of P. nobilis was recorded in the Gulf of Taranto (Southern Italy, Ionian Sea). Moribund specimens of P. nobilis were collected by scuba divers and processed by bacteriological, parasitological, histopathological and molecular analyses to investigate the causes of this MME. Different ...
Tópico(s): Marine Ecology and Invasive Species
2019 - Elsevier BV | Journal of Invertebrate Pathology
Michele Adolfo Tedesco, Giovanni Di Salvo, Francesco Natale, Valeria Pergola, Elvira Calabrese, Carolina Grassia, G Ratti, D Iarussi, A Iacono, Raffaele Calabrò, Giuliana Lama,
Background Comprehensive data are unavailable for cardiac abnormalities in patients with neurofibromatosis type 1 (NF1). The goal of this study was to evaluate the prevalence of cardiovascular abnormalities with echocardiography with color Doppler scan (ECHO) in a large, consecutive series of patients with NF1. Methods We studied 48 patients with NF1 (mean age, 10 years). Thirty healthy subjects comparable for age and sex served as the control group. All ECHO studies were performed by the same cardiologist ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2002 - Elsevier BV | American Heart Journal
Maria Russo, Rosanna Palumbo, Annalisa Mupo, Mariarosaria Tosto, Giuseppe Iacomino, Annamaria Scognamiglio, Idolo Tedesco, Giovanni Galano, Gian Luigi Russo,
Tópico(s): Retinoids in leukemia and cellular processes
2003 - Springer Nature | Oncogene
Carolina Grassia, Pier Francesco Rambaldi, Fabrizio Cioce, Michele Adolfo Tedesco, Giovanni Di Salvo, Maria Esposito-Salsano, Giuliana Lama, Luisa Graziano, Elvira Calabrese,
Tópico(s): Tuberous Sclerosis Complex Research
2004 - Springer Science+Business Media | Pediatric Nephrology
Michele Adolfo Tedesco, Giovanni Di Salvo, G Ratti, Francesco Natale, Elvira Calabrese, Carolina Grassia, A Iacono, Giuliana Lama,
Vascular disease is an underestimated complication of neurofibromatosis type 1 (NF1). The few studies available on this disease are based on case reports. The purpose of this study was to evaluate the relationship between 24-h systolic blood pressure (SBP) and 24-h heart rate obtained by ambulatory blood pressure monitoring and the carotid femoral pulse wave velocity, a widely used index of arterial distensibility, evaluated with Complior. We studied 64 young NF1 patients and 30 healthy subjects. ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2001 - Oxford University Press | American Journal of Hypertension
Leonardo Pace, Lucio Catalano, Silvana Del Vecchio, Francesca Di Gennaro, Amalia De Renzo, Giulia Sica, Catello Califano, Nicolina Tedesco, Giovanni Borrelli, Bruno Rotoli, Marco Salvatore,
Tópico(s): Radiopharmaceutical Chemistry and Applications
2001 - Springer Science+Business Media | European Journal of Nuclear Medicine
Michele Adolfo Tedesco, Giovanni Di Salvo, G Ratti, Francesco Natale, D Iarussi, A Iacono,
Abstract Background: Left atrial enlargement (LAE) is associated with an increased risk of death and cardiovascular (CV) hospitalization. Whether or not LAE reflects early structural change from hypertension is unclear. Hypothesis: The aim of this study was to evaluate the relationship between LA size, 24‐h blood pressure measurements, age, body mass index (BMI), and left ventricular mass index (LVMI) in hypertensive patients. Methods: We studied 164 outpatients (age range 30–76 years, 73 men and 91 ...
Tópico(s): Cardiovascular Effects of Exercise
2001 - Wiley | Clinical Cardiology
M Tedesco, Giovanni Di Salvo, Salvatore Caputo, Francesco Natale, G Ratti, D Iarussi, A Iacono,
This is the first European study that has evaluated educational level in a large sample of hypertensive outpatients. We established the educational level of the hypertensive outpatients in our unit, and determined whether the awareness of hypertension and its organ damage was education-related. We analysed data from 812 consecutive outpatients (378 men, mean age 50 ± 10 years) with essential stage I–II hypertension. Subjects were subdivided into two categories: group A subjects were highly educated; ...
Tópico(s): Chronic Disease Management Strategies
2001 - Springer Nature | Journal of Human Hypertension
Michele Riccio, Giuseppe De Falco, P. Mirone, Luca Maresca, Marianna Tedesco, Giovanni Breglio, Andrea Irace,
In this paper, a temperature-dependent compact SPICE model of reverse-conducting IGBTs (RC-IGBTs) is presented. The proposed solution is based on a quasi-two-dimensional (2-D) approach, with the use of IGBT and p-i-n diode subcircuits suitably connected to take into account the inner interactions among the two devices. The resulting device model is derived through physical considerations on the RC-IGBT internal behavior, carried out by means of wide area TCAD 2-D simulations. Transversal current path, ...
Tópico(s): Electromagnetic Compatibility and Noise Suppression
2016 - Institute of Electrical and Electronics Engineers | IEEE Transactions on Power Electronics
Assunta D’Amato, Raffaele Volpe, Maria Carmela Vaccaro, Stefania Terracciano, Ines Bruno, Massimo Tosolini, Consiglia Tedesco, Giovanni Pierri, Paolo Tecilla, Chiara Costabile, Giorgio Della Sala, Irene Izzo, Francesco De Riccardis,
Cyclic peptoids have recently emerged as important examples of peptidomimetics for their interesting complexing properties and innate ability to permeate biological barriers. In the present contribution, experimental and theoretical data evidence the intricate conformational and stereochemical properties of five novel hexameric peptoids decorated with N-isopropyl, N-isobutyl, and N-benzyl substituents. Complexation studies by NMR, in the presence of sodium tetrakis[3,5-bis(trifluoromethyl)phenyl] ...
Tópico(s): Microbial Natural Products and Biosynthesis
2017 - American Chemical Society | The Journal of Organic Chemistry
Laura Tedesco, Giovanni Corsetti, Chiara Ruocco, Maurizio Ragni, Fabio Rossi, Michele O. Carruba, Alessandra Valerio, Enzo Nisoli,
Chronic alcohol consumption promotes mitochondrial dysfunction, oxidative stress, defective protein metabolism, and fat accumulation in hepatocytes (liver steatosis). Inadequate amino acid metabolism is worsened by protein malnutrition, frequently present in alcohol-consuming patients, with reduced circulating branched-chain amino acids (BCAAs). Here we asked whether dietary supplementation with a specific amino acid mixture, enriched in BCAAs (BCAAem) and able to promote mitochondrial function in ...
Tópico(s): Diet, Metabolism, and Disease
2018 - American Physiological Society | AJP Gastrointestinal and Liver Physiology
Carmine Buonocore, Pietro Tedesco, Giovanni Andrea Vitale, Fortunato Palma Esposito, Rosa Giugliano, Maria Chiara Monti, Maria Valeria D’Auria, Donatella de Pascale,
Rhamnolipids (RLs) are surface-active molecules mainly produced by Pseudomonas spp. Antarctica is one of the less explored places on Earth and bioprospecting for novel RL producer strains represents a promising strategy for the discovery of novel structures. In the present study, 34 cultivable bacteria isolated from Edmonson Point Lake, Ross Sea, Antarctica were subjected to preliminary screening for the biosurfactant activity. The positive strains were identified by 16S rRNA gene sequencing and ...
Tópico(s): Microbial Community Ecology and Physiology
2020 - Multidisciplinary Digital Publishing Institute | Marine Drugs
Michele Adolfo Tedesco, Giovanni Di Salvo, Francesco Natale, Luisa Graziano, Carolina Grassia, Raffaele Calabrò, Giuliana Lama,
Hypertension is frequently associated with neurofibromatosis type 1 (NF1), a common inherited disease that limits life expectancy. No data are available on cardiac damage in NF1 patients with hypertension. We evaluated cardiac function in NF1 patients with hypertension diagnosed by 24-h ambulatory blood pressure monitoring (ABPM), compared with normal children.We studied 73 NF1 patients (41 boys; mean age 12 years) and 30 normal children comparable for age and sex, using standard 2D echocardiography, ...
Tópico(s): Adrenal and Paraganglionic Tumors
2004 - Elsevier BV | International Journal of Cardiology
Antonia Di Mola, Antonio Macchia, Consiglia Tedesco, Giovanni Pierri, Laura Palombi, Rosanna Filosa, António Massa,
Abstract Herein we report new methodologies for the synthesis of the challenging ketones 2‐cyanobenzophenones, based on Suzuki‐Miyaura type cross‐coupling reactions and very mild oxidation of 2‐benzylbenzonitriles. The investigation of the reactivity of the obtained ketones highlighted a very good electrophilicity in the presence of mild carbon‐ and hetero‐nucleophiles, allowing the synthesis of 3,3‐disubstituted isoindolin‐1‐ones. All the developed methodologies are highly efficient and tolerate ...
Tópico(s): Synthetic Organic Chemistry Methods
2019 - Wiley | ChemistrySelect
Antonio Macchia, Francesco F. Summa, Antonia Di Mola, Consiglia Tedesco, Giovanni Pierri, Armin R. Ofial, Guglielmo Monaco, António Massa,
Cascade reactions of ortho-carbonyl-substituted benzonitriles with ((chloromethyl)sulfonyl)benzenes as pronucleophiles led to new isoindolin-1-ones with a tetrasubstituted C-3 position or to (Z)-3-(sulfonyl-methylene)isoindolin-1-ones. The reactions start from readily available materials, are carried out under mild conditions, and do not require metal catalysis. Promoted only by the cheap and environmentally benign K2CO3 as the base, up to six elemental steps can be combined in a single pot. Hence, ...
Tópico(s): Synthetic Organic Chemistry Methods
2021 - American Chemical Society | The Journal of Organic Chemistry
Marta Castrica, D. Tedesco, Sara Panseri, Giovanni Ferrazzi, Vera Ventura, Dario G. Frisio, C. Balzaretti,
Food loss and waste have a negative environmental impact due to the water, land, energy and other natural resources used to produce the wasted food, along with post-consumption disposal costs. Reducing food waste will thus help improve sustainability and decrease the environmental impact of the food system. Using food waste for animal feed is of growing importance in terms of the policies targeted at tackling food waste but the current legal framework in the European Union (EU) strongly restricts ...
Tópico(s): Agriculture Sustainability and Environmental Impact
2018 - Multidisciplinary Digital Publishing Institute | Sustainability
Michele Adolfo Tedesco, G Ratti, Giovanni Di Salvo, Francesco Natale,
Tópico(s): Hormonal Regulation and Hypertension
2002 - Adis, Springer Healthcare | Drugs & Aging
M Tedesco, Francesco Natale, Giovanni Di Salvo, Salvatore Caputo, Michele Capasso, Raffaele Calabrò,
Tópico(s): Cardiovascular Function and Risk Factors
2004 - Springer Nature | Journal of Human Hypertension
Giuseppe D’Antona, Laura Tedesco, Chiara Ruocco, Giovanni Corsetti, Maurizio Ragni, Andrea Fossati, Elisa Saba, Francesca Fenaroli, Mery Montinaro, Michele O. Carruba, Alessandra Valerio, Enzo Nisoli,
Aims: Myopathy, characterized by mitochondrial oxidative stress, occurs in ∼10% of statin-treated patients, and a major risk exists with potent statins such as rosuvastatin (Rvs). We sought to determine whether a peculiar branched-chain amino acid-enriched mixture (BCAAem), found to improve mitochondrial function and reduce oxidative stress in muscle of middle-aged mice, was able to prevent Rvs myopathy. Results: Dietary supplementation of BCAAem was able to prevent the structural and functional alterations ...
Tópico(s): Adipose Tissue and Metabolism
2016 - Mary Ann Liebert, Inc. | Antioxidants and Redox Signaling
Mary Chesshyre, Deborah Ridout, Yasumasa Hashimoto, Yoko Ookubo, Silvia Torelli, Kate Maresh, Valeria Ricotti, Lianne Abbott, Vandana Ayyar Gupta, Marion Main, Giuliana Ferrari, Anna Kowala, Yung‐Yao Lin, Francesco Saverio Tedesco, Mariacristina Scoto, Giovanni Baranello, Adnan Manzur, Yoshitsugu Aoki, Francesco Muntoni,
Duchenne muscular dystrophy (DMD) is caused by DMD mutations leading to dystrophin loss. Full-length Dp427 is the primary dystrophin isoform expressed in muscle and is also expressed in the central nervous system (CNS). Two shorter isoforms, Dp140 and Dp71, are highly expressed in the CNS. While a role for Dp140 and Dp71 on DMD CNS comorbidities is well known, relationships between mutations expected to disrupt Dp140 and Dp71 and motor outcomes are not.Functional outcome data from 387 DMD boys aged ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
2022 - Springer Science+Business Media | Journal of Cachexia Sarcopenia and Muscle
Michele Adolfo Tedesco, Giovanni Di Salvo, Francesco Natale, Salvatore Caputo, Elvira Calabrese, Carolina Grassia, G Ratti, D Iarussi, A Iacono, Giuliana Lama,
Neurofibromatosis includes at least 2 different autosomal dominant genetic disorders: neurofibromatosis (NF) type 1 and NF type 2. NF represents 95% of such cases with an incidence of 1 in 3,500 newborns and a prevalence of 1 in 4,500 newborns. 1 Riccardi V.M Von Recklinghausen neurofibromatosis. N Engl J Med. 1981; 27: 1617-1627 Crossref Scopus (999) Google Scholar , 2 Listermck R Charrow J Neurofibromatosis type 1 in childhood. J Pediatr. 1990; 16: 845-851 Abstract Full Text PDF Scopus (109) Google ...
Tópico(s): Cardiac tumors and thrombi
2001 - Elsevier BV | The American Journal of Cardiology
Luciano De Sio, Alessandro Veltri, Roberto Caputo, Antonio De Luca, Giuseppe Strangi, Roberto Bartolino, Cesare Umeton,
... of the articles: Sameh Ferjani, Luigia Pezzi, Alessandro Tedesco, Ivan Trebisacce from our Department; Giovanni Gilardi, Rita Asquini, Antonio d'Alessandro, from Dipartimento ...
Tópico(s): Photorefractive and Nonlinear Optics
2013 - Taylor & Francis | Liquid Crystals Reviews
The article explores the history of the pulpit from the church Sant'Andrea designed by artist Giovanni Pisano in Pistoia, Italy. The author reflects on the pulpit's description in a revised edition of the book “Le Vite de'piu eccellenti pittori scultori e architettori nelle redazioni del 1550 e 1568” by historian Giorgio Vasari. Emphasis is given an analysis of the historical accuracy of Vasari's account and the role of institutional competition in the commission and construction of the pulpit. Other ...
Tópico(s): Libraries, Manuscripts, and Books
2011 - Deutscher Kunstverlag | Zeitschrift für Kunstgeschichte
Niccolò Vendramin, Pierpaolo Patarnello, Anna Toffan, Valentina Panzarin, Elisabetta Cappellozza, Perla Tedesco, Antonio Terlizzi, Calogero Terregino, Giovanni Cattoli,
Abstract Background Betanodaviruses are the causative agents of Viral Encephalopathy and Retinopathy (VER). To date, more than 50 species have proved to be susceptible and among them, those found in genus Epinephelus are highly represented. Clinical disease outbreaks are generally characterized by typical nervous signs and significant mortalities mainly associated with aquaculture activities, although some concerns for the impact of this infection in wild fish have been raised. In this study, the ...
Tópico(s): Mosquito-borne diseases and control
2013 - BioMed Central | BMC Veterinary Research
Anna Urciuolo, Marco Quarta, Valeria Morbidoni, Francesca Gattazzo, Sibilla Molon, Paolo Grumati, Francesca Montemurro, Francesco Saverio Tedesco, Bert Blaauw, Giulio Cossu, Giovanni Vozzi, Thomas A. Rando, Paolo Bonaldo,
Adult muscle stem cells, or satellite cells have essential roles in homeostasis and regeneration of skeletal muscles. Satellite cells are located within a niche that includes myofibers and extracellular matrix. The function of specific extracellular matrix molecules in regulating SCs is poorly understood. Here, we show that the extracellular matrix protein collagen VI is a key component of the satellite cell niche. Lack of collagen VI in Col6a1–/– mice causes impaired muscle regeneration and reduced ...
Tópico(s): Mesenchymal stem cell research
2013 - Nature Portfolio | Nature Communications
Antonio Olita, Leopoldo Fazioli, Costanza Tedesco, Simone Simeone, Andrea Cucco, Giovanni Quattrocchi, Alberto Ribotti, Angelo Perilli, Federica Pessini, Roberto Sorgente,
A forecasting and hazard assessment system for oil dispersion from Italian oil rigs was set up within the framework of a national research project. The system is based on 3D hydrodynamic, mesoscale resolving models providing forcing fields for a Lagrangian module of oil dispersion and slick evolution (oil transport and transformation). The tool provides,daily, the outputs of numerical simulations of possible oil spills from extraction platform sites. In this work we present the results for the 3 ...
Tópico(s): Marine and coastal ecosystems
2019 - Frontiers Media | Frontiers in Marine Science
Maria Russo, Idolo Tedesco, Giuseppe Iacomino, Rosanna Palumbo, Giovanni Galano, Gian Luigi Russo,
Regular consumption of fruit and vegetables is associated with reduced risks of cancer, cardiovascular disease and other aging-related diseases. Convincing evidence exists suggesting that an increased fruit, vegetables, and grains consumption is a relatively easy and practical strategy to significantly reduce the incidence of chronic diseases. Cancer chemoprevention intends to interrupt the carcinogenesis process, which includes initiation, promotion and progression of otherwise normal cells to ...
Tópico(s): Nutrition, Genetics, and Disease
2005 - Bentham Science Publishers | Current Medicinal Chemistry - Immunology Endocrine & Metabolic Agents
Consiglia Tedesco, Rosaria Schettini, Veronica Iuliano, Giovanni Pierri, Andrew N. Fitch, Francesco De Riccardis, Irene Izzo,
Formation of stable porous frameworks based on cyclic peptoids can be triggered by strategic choice of appropriate side chains. In this contribution we demonstrate that substitution of distal propargyl side chains with methoxyethyl groups in a fully propargylated cyclic octamer peptoid (cyclo-(Npa)8 1) greatly improves the solid state stability inducing permanent one-dimensional porosity of the compound (cyclo-[(NPa)3(Nme)]2 2, Npa = N-(propargyl)glycine, Nme = N-(methoxyethyl)glycine). In both compounds ...
Tópico(s): Supramolecular Self-Assembly in Materials
2018 - American Chemical Society | Crystal Growth & Design