Anfumbom Kfutwah, Mathurin Cyrille Tejiokem, Francis Ndongo Ateba, Jean Audrey Ndongo, Calixte Ida Penda, Paul Alain Tagnouokam‐Ngoupo, Patrice Tchendjou, Gisèle Chewa, P. Boisier, Christine Rouzioux, Josiane Warszawski, Albert Faye,
... Alain T. Ngoupo, MSc* Patrice Tchendjou, MD, MPH† Gisele Chewa, MD# Pascal Boisier, MD, PhD† Christine Rouzioux, PharmD, PhD** Josiane ...
Tópico(s): HIV/AIDS drug development and treatment
2011 - Lippincott Williams & Wilkins | JAIDS Journal of Acquired Immune Deficiency Syndromes
Joerg Kallen, A. Goepfert, Anke Blechschmidt, Aude Izaac, Martin Geiser, Gisele Tavares, Paul Ramage, Pascal Furet, Keiichi Masuya, Joanna Lisztwan,
p53 tumor suppressor activity is negatively regulated through binding to the oncogenic proteins Hdm2 and HdmX. The p53 residues Leu(26), Trp(23), and Phe(19) are crucial to mediate these interactions. Inhibiting p53 binding to both Hdm2 and HdmX should be a promising clinical approach to reactivate p53 in the cancer setting, but previous studies have suggested that the discovery of dual Hdm2/HdmX inhibitors will be difficult. We have determined the crystal structures at 1.3 A of the N-terminal domain ...
Tópico(s): RNA modifications and cancer
2009 - Elsevier BV | Journal of Biological Chemistry
Christine Chaussé, Chantal Leroyer, Olivier Girardclos, Gisèle Allenet, Patrick Pion, Pascal Raymond,
Bio-chronostratigraphic observations compiled from Quai-Branly in Paris (France) and their comparison with previous studies in the Paris Basin allow documentation of the morphodynamic evolution of the River Seine during the middle and late Holocene. This history begins in the Boreal (between 9500 and 8850 cal. BP), with the deposition of tufa, expressing a stabilized river bed. During the second part of the sub-Boreal the water-table was low. At the beginning of the sub-Atlantic (towards 2800/2700 ...
Tópico(s): Maritime and Coastal Archaeology
2008 - SAGE Publishing | The Holocene
Gisèle Mautino, Nicolás Oliver, Pascal Chanez, Jean Bousquet, Françoise Capony,
Section:ChooseTop of pageAbstract <<Materials and MethodsResultsDiscussionReferencesCITING ARTICLES
Tópico(s): Coagulation, Bradykinin, Polyphosphates, and Angioedema
1997 - American Thoracic Society | American Journal of Respiratory Cell and Molecular Biology
Nicole Martin‐Moutôt, Pascal Mansuelle, Gisèle Alcaraz, Raquel Gouvêa dos Santos, Marta N. Cordeiro, Maria Elena de Lima, Michael Seagar, Catherine Van Renterghem,
A toxin was purified to homogeneity from the venom of the South American armed spider Phoneutria nigriventer and found to have a molecular mass of 8600 Da and a C-terminally amidated glycine residue. It appears to be identical to Toxin 1 (Tx1) isolated previously from this venom. Tx1 reversibly inhibited sodium currents in Chinese hamster ovary cells expressing recombinant sodium (Na v 1.2) channels without affecting their fast biophysical properties. The kinetics of inhibition of peak sodium current ...
Tópico(s): Neuroscience and Neuropharmacology Research
2006 - American Society for Pharmacology and Experimental Therapeutics | Molecular Pharmacology
Marie‐Bernard Lascombe, Christophe Grégoire, Pascal Poncet, Gisele Tavares, Isabelle Rosinski‐Chupin, J. Rabillon, Hany Goubran‐Botros, J C Mazié, Bernard David, Pedro M. Alzari,
The three-dimensional structure of the major horse allergen Equ c 1 has been determined at 2.3 Å resolution by x-ray crystallography. Equ c 1 displays the typical fold of lipocalins, a β-barrel flanked by a C-terminal α-helix. The space between the two β-sheets of the barrel defines an internal cavity that could serve, as in other lipocalins, for the binding and transport of small hydrophobic ligands. Equ c 1 crystallizes in a novel dimeric form, which is distinct from that observed in other lipocalin ...
Tópico(s): Food Allergy and Anaphylaxis Research
2000 - Elsevier BV | Journal of Biological Chemistry
Agnès Marchio, Mounira Meddeb, Pascal Pineau, Gisèle Danglot, Pierre Tiollais, Alain Bernheim, Anne Dejean,
Comparative genomic hybridization (CGH) was used to evaluate and map genomic aberrations in 50 hepatocellular carcinomas (HCCs) from patients chronically infected with hepatitis B virus (HBV). CGH clearly detected nonrandom genomic imbalances. Losses were most prevalent on chromosome regions 4q (70%), 8p (65%), 16q (54%), 17p (51%), 13q and 6q (37% each), and lp (30%). The most frequent gains occurred on 8q (60%), 1q (58%), and 6p and 17q (33% each). In a few cases, sequence amplifications were detected that ...
Tópico(s): Cancer Genomics and Diagnostics
1997 - Wiley | Genes Chromosomes and Cancer
Florence Pédeutour, Sandra Merscher, E. Durieux, Kate Montgomery, Kenneth Krauter, Jean-Pascal Clevy, Gisèle Barcelo, Raju Kucherlapati, Patrick Gaudray, Claude Turc‐Carel,
The consistent involvement of the region 12q13-q15 in numerous human tumors speaks in favor of the presence of genes that may contribute to oncogenesis. Mapping genes within this region of chromosome 12 is a necessary step toward the identification of those that play a role in this process. We have undertaken a multiplex analysis using translocation breakpoint mapping to order from the centromere to the telomere a series of 24 loci from the region 12q12-q22. Thirteen adipose tissue tumors with seven ...
Tópico(s): Melanoma and MAPK Pathways
1994 - Elsevier BV | Genomics
Gisèle Mautino, Nathalie Paul‐Eugène, Pascal Chanez, Antonio M. Vignola, Jean Pierre Kolb, Jean Bousquet, Bernard Dugas,
Abstract The generation of nitric oxide by human monocytes has long been a subject of controversy because of the difficulty of rationalizing this production. In this work we evaluated the capacity of human monocytes to produce nitric oxide (NO) as measured by nitrite (NO2-) release. Resting unstimulated monocytes (2 106 cells/ml) were found to produce significant amounts of NO2- after 8 to 12 days in culture. This production appeared to be highly heterogeneous. Indeed, approximatively, 75% of monocytes ...
Tópico(s): Neuroinflammation and Neurodegeneration Mechanisms
1994 - Oxford University Press | Journal of Leukocyte Biology
Rabah Ben Yaou, Aurélie Hubert, Isabelle Nelson, Julia R. Dahlqvist, David Gaist, Nathalie Streichenberger, Maud Beuvin, Martin Krahn, Philippe Petiot, Frédéric Parisot, Fabrice Michel, Edoardo Malfatti, Norma B. Romero, Robert Carlier, B. Eymard, Philippe Labrune, Morten Dunø, Thomas Krag, Mathieu Cérino, Marc Bartoli, Gisèle Bonne, John Vissing, Pascal Laforêt, François Petit,
To describe the variability of muscle symptoms in patients carrying mutations in the GYG1 gene, encoding glycogenin-1, an enzyme involved in the biosynthesis of glycogen, and to discuss genotype-phenotype relations.We describe 9 patients from 5 families in whom muscle biopsies showed vacuoles with an abnormal accumulation of glycogen in muscle fibers, partially α-amylase resistant suggesting polyglucosan bodies. The patients had either progressive early-onset limb-girdle weakness or late-onset distal ...
Tópico(s): Neurogenetic and Muscular Disorders Research
2017 - Wolters Kluwer | Neurology Genetics
Agnès Marchio, Mounira Meddeb, Pascal Pineau, Gisèle Danglot, Pierre Tiollais, Alain Bernheim, Anne Dejean,
... FranceSearch for more papers by this authorPascal Pineau, Pascal Pineau Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this authorGisèle Danglot, Gisèle Danglot Laboratoire de Cytogénétique et de Génétique Oncologiques ( ... FranceSearch for more papers by this authorPascal Pineau, Pascal Pineau Unité de Recombinaison et Expression Génétique, INSERM U163, Institut Pasteur, Paris, FranceSearch for more papers by this authorGisèle Danglot, Gisèle Danglot Laboratoire de Cytogénétique et de Génétique Oncologiques ( ...
Tópico(s): Liver Disease Diagnosis and Treatment
1997 - Wiley | Genes Chromosomes and Cancer
Laurent Mandelbrot, Roland Tubiana, Jérôme Le Chenadec, Catherine Dollfus, Albert Faye, E. Pannier, Sophie Matheron, Marie-Aude Khuong, Valérie Garrait, Véronique Reliquet, Alain Devidas, Alain Berrébi, C Allisy, Christophe Elleau, C. Arvieux, Christine Rouzioux, Josiane Warszawski, Stéphane Blanche, Laurent Mandelbrot, C. Crenn-Hébert, Corinne Floch-Tudal, Fabienne Mazy, Marine Joras, Françoise Meier, Emmanuel Mortier, Pierre‐François Ceccaldi, Maïa Banigé, Agnès Uludag, Virginie Zarouk, A. Lefort, Gilles Hittinger, Jean-Marc Chamouilli, Christian Burle, Alain Lafeuillade, Marie Medus, Germaine Bachelard, Joëlle Dendale-Nguyen, Thomas Guimard, Karine Guimard, Jean-Pierre Brossier, Philippe Van de Perre, Jean-Luc Esnault, Olivier Bollengier Stragier, Sophie Leautez-Nainville, Sandrine-Anne Martha, Benoît Martha, E. Maurel, Michel Françoise, Muriel Barat, Patricia Murger, Mahfoud Rouha, P Lumbroso, A Checoury, Pascale Perfezou, Gilles Blondin, Séverine Ansart, Luc de Saint Martin, Philippe Le Moine, Corinne Daniel, Christian Calvez, Emmanuelle Boutard, C. Arvieux, Estelle Bauville, Christelle Dupre, Yves Poinsignon, Anne Grelier, Gaétane Mousset, Corinne Cudeville, Mathilde Niault, Isabelle Belzic, Philippe Moreau, Marie-Françoise Le Coz, Odile Luycx Vaillant, Virginie Vitrat, D. Tardif, Jacques Gaillat, Anne Vanderbergh, Suzanne Braig, Marion Dehlinger-Paul, Khaled Mohamed, Brigitte Heller-Roussin, Cécile Winter, Ghislaine Firtion, E. Pannier, Myriam Costa, Odile Launay, Dominique Salmon Ceron, Sophie Matheron, Mandovi Rajguru, Neila Elaoun, Lahcene Allal, Élie Azria, Agnès Bourgeois Moine, Valérie Garrait, Isabelle Hau, Claudine Touboul, Lanto Ratsimbazafy, Christiane Kommé, Brigitte Elharrar, Jean-Marc Labaune, Laurent Cotte, R.-C. Rudigoz, Christophe Elleau, Camille Runel-Belliard, Thierry Pistone, Blandine Muanza, E. Broustal, Marc Duval-Arnould, Bénédicte Carpentier, Etienne Dienga, MariaLuisa Partisani, Natacha Entz‐Werlé, Éric David, David Rey, Hervé Seaume, Sarah Ducrocq, Philippe Bailly-Salin, J Tricoire, Alain Berrébi, Claudine Cayla, Anne Chacé, Isabelle Metheron, Anne Boutemy, Didier Armangaud, Sophie Couderc, Corinne Routier, A. Alissa, E. Questiaux, Ahmed S. Zakaria, Hélène Dauphin, Céline Goissen, Marie Belloy, Jean-Luc Delassus, MariaLuisa Partisani, Christine Cheneau, Jean-Marie Lang, Dominique Brault, C Allisy, Marie-Gisèle Lebrette, Lise Selleret, François Hervé, Pascal Bolot, Marie-Aude Khuong-Josses, Dieudonné Ekoukou, S. Bounan, Stéphane Blanche, Delphine Lemercier, Pierre Frange, Florence Veber, Alain Fisher, Michèle Granier, Alain Devidas, Rose Nguyen, Adrien May, Amélie Chabrol, Pierre Chevojon, Ziad Moussa, Claire Pluchart, Christine Rouger, Roland Tubiana, Manuela Bonmarchand, Luminata Shneider, Fabienne Caby, Ruxandra-Oana Calin, Anne Coursol, V. Chambrin, Philippe Labrune, Laure Clech, Isolde Pauly-Ravelly, Raghad Moalim, Lydie Sanchez, Ama Johnson, Eric Lachassine, L. Benoist, Vincent Jeantils, J. Gaudelus, Amélie Benbara, Anne Borgne, Leïla Karaoui, Véronique Lefevre Elbert, A. Bongain, Fabrice Monpoux, Anne Deville, Eliane Galiba, Antoine Doumet, Jean-Luc Schmidt, L. Cravello, Claire Hubert, Catherine Dollfus, François Hervé, Marie‐Dominique Tabone, Mary‐France Courcoux, Guy Leverger, B. Carbonne, Didier Pinquier, Brigitte Clavier, Gaëlle Pinto-Cardoso, Albert Faye, Sophie Matheron, Martine Lévine, Erianna Bellaton Marouts, Constance Borie, Christine Boissinot, Delphine Peretti, Corinne Fourcade, Catherine Chirouze, Cécile Hafner Mauvais, Véronique Reliquet, Cécile Brunet-Cartier, Norbert Winer, Edouard Vaucel, Claire Briandet, Jacques Brouard, A. Chalvon Demersay, Véronique Hentgen, Fabienne Messaoudi, Louis Bernard, Zoha Maakroun, Pascale Nau, Kamila Kébaïli, Kareen Billiemaz, Ramona Abrudan, Pascale Fialaire, Loïc Sentilhes, Stéphanie Proust, Philippe Arsac, Louis Mesnard, Evelyne Werner, N Ciraru‐Vigneron, G Mouchnino, D Ayral, Emmanuelle Vintejoux, Muriel Lalande, Jacques Reynes, Michel Segondy, Christiane De Gennes, C Clavel, Françoise Mazingue, Yamina Hammou, Faïza Ajana, Yves Hatchuel, Imad Nahri, Claire Genet, Sophie Ducroix-Roubert, Yves Aubrard, Anne Constanty, P. Weinbreck, Emilie Piet, Françoise Jacquier, Christophe Michau, Hassan Safwan, A. Boutet, Mohamed Abdelhadi, Narcisse Elenga, Stéphane Blanche, Sandrine Delmas, Catherine Dollfus, Albert Faye, Pierre Frange, Jérôme Le Chenadec, Laurent Mandelbrot, Anaïs Perilhou, Christine Rouzioux, Jeanne Sibiude, Roland Tubiana, Josiane Warszawski,
Abstract Background. The efficacy of preventing perinatal transmission (PT) of human immunodeficiency virus type 1 (HIV-1) depends on both viral load (VL) and treatment duration. The objective of this study was to determine whether initiating highly active antiretroviral therapy (ART) before conception has the potential to eliminate PT. Methods. A total of 8075 HIV-infected mother/infant pairs included from 2000 to 2011 in the national prospective multicenter French Perinatal Cohort (ANRS-EPF) received ...
Tópico(s): HIV, Drug Use, Sexual Risk
2015 - Oxford University Press | Clinical Infectious Diseases
Clément Taron-Brocard, Jérôme Le Chenadec, Albert Faye, Catherine Dollfus, Tessa Goetghebuer, Vincent Gajdos, Jean-Marc Labaune, Anaïs Perilhou, Laurent Mandelbrot, Stéphane Blanche, Josiane Warszawski, Laurent Mandelbrot, C. Crenn-Hébert, Corinne Floch-Tudal, Fabienne Mazy, Marine Joras, Françoise Meier, E. Mortier, Pierre‐François Ceccaldi, Maïa Banigé, Agnès Uludag, Virginie Zarouk, A. Lefort, Gilles Hittinger, J.-M. Chamouilli, Christian Burle, Alain Lafeuillade, M. Médus, Gastón Bachelard, Joëlle Dendale-Nguyen, Thomas Guimard, Karine Guimard, Jacques Brossier, Philippe Van de Perre, J.-L. Esnault, Olivier Bollengier Stragier, Sophie Leautez-Nainville, Sandrine Anne Martha, B. Martha, E. Maurel, M Françoise, M. Barat, Patricia Murger, Mahfoud Rouha, P Lumbroso, A Checoury, Pascale Perfezou, G Blondin, Séverine Ansart, Luc de Saint Martin, Philippe Le Moine, C Daniel, Christian Calvez, Emmanuelle Boutard, C. Arvieux, Estelle Bauville, Caroline Dupré, Yves Poinsignon, Aurore Grelier, Gaétane Mousset, Corinne Cudeville, M. Niault, Isabelle Belzic, Philippe Moreau, Marie Francoise Le Coz, O. Vaillant, Virginie Vitrat, D. Tardif, J. Gaillat, Anne Vanderbergh, Suzanne Braig, M. Dehlinger-Paul, Kamal A. Mohamed, Brigitte Heller-Roussin, Cécile Winter, Ghislaine Firtion, E. Pannier, Maria Laura Costa, Odile Launay, Dominique Salmon Ceron, Sophie Matheron, M. Rajguru, Neila Elaoun, Lahcene Allal, Élie Azria, Agnès Bourgeois Moine, Valérie Garrait, Isabelle Hau, Cyril Touboul, Lanto Ratsimbazafy, Christiane Kommé, Brigitte Elharrar, Jean-Marc Labaune, Laurent Cotte, R.-C. Rudigoz, Christophe Elleau, C. Runel-Belliard, T. Pistone, Blandine Muanza, E. Broustal, Marc Duval-Arnould, Benjamin Carpentier, Е.М. Дєньга, Marialuisa Partisani, Natacha Entz‐Werlé, Elizabeth A. David, D. Rey, H. Seaume, Sarah Ducrocq, P. Bailly-Salin, J Tricoire, A Berrébi, C. Cayla, Anne Chacé, Isabelle Metheron, Anne Boutemy, Didier Armangaud, Sophie Couderc, Cédric Routier, A. Alissa, E. Questiaux, Asma Zakaria, H. Dauphin, C. Goissen, Marie Belloy, J.-L. Delassus, Marialuisa Partisani, Geneviève Chêne, J. Lang, Dominique Brault, C Allisy, Marie-Gisèle Lebrette, Lise Selleret, François Hervé, Pascal Bolot, Marie-Aude Khuong-Josses, Dieudonné Ekoukou, S. Bounan, Stéphane Blanche, Delphine Lemercier, Pierre Frange, Florence Veber, A. Fisher, Michèle Granier, A. Devidas, Ruby H.N. Nguyen, A. May, Amélie Chabrol, P. Chevojon, Ziad Moussa, Claire Pluchart, C. Rouger, Roland Tubiana, Manuela Bonmarchand, Luminata Shneider, Fabienne Caby, Ruxandra-Oana Calin, Anne Coursol, V. Chambrin, Philippe Labrune, Laure Clech, I. Pauly-Ravelly, Raghad Moalim, L. Sánchez, Johnson Adekunle Adeniji, Eric Lachassine, L. Benoist, Vincent Jeantils, J. Gaudelus, Amélie Benbara, Anne Borgne, Lamis R. Karaoui, V. L. Elbert, A. Bongain, Fabrice Monpoux, Anne Deville, E. Galiba, Antoine Doumet, J.-L. Schmidt, L. Cravello, C. Hubert, Catherine Dollfus, François Hervé, M.-D. Tabone, Mary‐France Courcoux, Guy Leverger, B. Carbonne, Didier Pinquier, Brigitte Clavier, Gaëlle Pinto-Cardoso, Albert Faye, Sophie Matheron, Michael A. Levine, E. B. Marouts, Claire Borie, Christine Boissinot, de Peretti, C. R. Fourcade, C Chirouze, Cécile Hafner Mauvais, Véronique Reliquet, Cécile Brunet-Cartier, Norbert Winer, E. Vaucel, Claire Briandet, J. Brouard, A. Chalvon Demersay, Véronique Hentgen, Fathi Messaoudi, L. Bernard, Z. Maakroun, Pascale Nau, Kamila Kébaïli, Kareen Billiemaz, Ramona Abrudan, Pascale Fialaire, S. Proust, Philippe Arsac, Louis Mesnard, Ellen G. Werner, N Ciraru‐Vigneron, G Mouchnino, D Ayral, E. Vintejoux, M. Lalande, J. Reynes, Michel Segondy, Christiane De Gennes, C Clavel, Françoise Mazingue, Yamina Hammou, F. Ajana, Yves Hatchuel, Imad Nahri, Claire Genet, Sophie Ducroix-Roubert, Yves Aubrard, A. Constanty, P. Weinbreck, Emilie Piet, F. Jacquier, Christophe Michau, Hassan Safwan, A. Boutet, Mohamed Abdelhadi, Narcisse Elenga, Stéphane Blanche, S. Delmas, Catherine Dollfus, Albert Faye, Jérôme Le Chenadec, Laurent Mandelbrot, Anaïs Perilhou, C Rouzioux, Jeanne Sibiude, Jean‐Paul Teglas, Roland Tubiana, Josiane Warszawski,
Background. Morbidity and mortality are higher among human immunodeficiency virus (HIV) exposed but uninfected (HEU) infants than unexposed infants, particularly if the mother had a low CD4 count. We investigated the possible association between maternal immune depression during pregnancy and the risk of infection in HEU infants in the national French Perinatal Cohort (EPF). Methods. All neonates, born alive, to HIV-1–infected women enrolled in the EPF between 2002 and 2010 were included. The primary ...
Tópico(s): COVID-19 Impact on Reproduction
2014 - Oxford University Press | Clinical Infectious Diseases
Nelly Briand, Josiane Warszawski, Laurent Mandelbrot, Catherine Dollfus, E. Pannier, L. Cravello, Rose Nguyen, Sophie Matheron, Norbert Winer, Roland Tubiana, Christine Rouzioux, Albert Faye, Stéphane Blanche, Laurent Mandelbrot, Françoise Meier, Dominique Duro, Marine Joras, E. Mortier, C. Crenn-Hébert, Corinne Floch-Tudal, Fabienne Mazy, M. Bensalah, Agnès Villemant-Uludag, A. Lefort, Virginie Zarrouk, Pierre‐François Ceccaldi, Gisèle Philip, Gilles Hittinger, Martine Malet, B. Bachelard, Marie Medus, Joëlle Dendale-Nguyen, Jean-Pierre Brossier, Olivier Aubry, Jean-Luc Esnault, S Léautez, Philippe Van de Perre, Isabelle Suaud, Sandrine-Anne Martha, Mahfoud Rouha, Pascale Perfezou, G Blondin, Charles Bellot, Séverine Ansart, Philippe Le Moine, Karine Bages-Jaffuel, Jean-Charles Duthé, M. Garrè, S. Jaffuel, Corinne Daniel, Christian Calvez, C. Beuscart, Emmanuelle Boutaric, Jennifer Rohan, Sylvie Lemoal, L. Lassel, Ghislaine Cotten, Caroline Dupré, Esther Beauville, C. Arvieux, Anabèle Dos Santos, Corinne Cudeville, Yves Poinsignon, Virginie Mouton-Rioux, Gaétane Mousset, Anne Grellier, Philippe Moreau, Philippe Tillaut, Virginie Mouton-Rioux, Odile Luycx-Vaillant, Philippe De Morel, Marie-Françoise Le Coz, Isabelle Belzic, M. Niault, Anne Vandenbergh, C. Janssen, Suzanne Braig, Virginie Vitrat, J. Gaillat, Gaëlle Clavere, J.P. Bru, Blandine Peyret, Catherine Mullard, Marie Echard, Philippe Talon, Marjorie Dehlinger, Cécile Winter, Brigitte Heller-Roussin, Odile Launay, M Fouchet, Ghislaine Firtion, Isabelle Goupil, E. Pannier, Nora Boudjoudi, Agnès Bourgeois-Moine, M Bodard, Valérie Vivier, Mandovi Rajguru, Virginie Huri, Élie Azria, Sophie Matheron, Neila Elaoun, Philippe Faucher, Valérie Garrait, Christiane Kommé, Isabelle Hau, Laurent Richier, Claudine Touboul, V. Thoirain, Laurent Cotte, Olivier Tariel, J. Koffi, Jean-Marc Labaune, C. Brochier, Denis Roux, Christophe Elleau, Camille Runel, Henri Bataille, Marie-Thérèse Sow, Ketty Samar, Blandine Muanza, Mélanie Duval, Clarisse Kingue-Ekollo, Bénédicte Carpentier, Isabelle Ronda, Jean-Marc Chamouilli, Natacha Entz‐Werlé, Hervé Seaume, Sarah Ducrocq, Philippe Bailly-Salin, Yvon Lemercier, J Tricoire, Alain Berrébi, Michèle Antras, Evelyne Armand, Claudine Cayla, F. Bonnal, Catherine Chabanier, Sophie Matheron, Anne Chacé, Sophie Couderc, Anne Boutemy, Marie-Christelle Dallot, A. Alissa, Corinne Routier, Ahmed S. Zakaria, Véronique Favret, Juliette Gerbe, E. Questiaux, MariaLuisa Partisani, David Rey, Christine Cheneau, C Allisy, Dominique Brault, François Hervé, Marie-Gisèle Lebrette, Lise Selleret, Dieudonné Ekoukou, Pascal Bolot, Marie-Aude Khuong-Josses, Marie-Christine Allemon, N Ghibaudo, Pierre Frange, Christine Rouzioux, Florence Veber, Stéphane Blanche, Delphine Lemercier, Marie-Christine Mourey, Gilles Blasquez, Michèle Granier, Houda Touahri, Rose Nguyen, Alain Devidas, I. Nisand, Michèle Weil, Christophe Vayssière, Jean‐Luc Berger, Martine Münzer, O. Graesslin, Anne-Florence Naime-Alix, Roland Tubiana, Frédérique Quetin, Anne Laubies, Manuela Bonmarchand, Jennifer Sommer, Patricia Bourse, Anne Coursol, Manal E. Youssef, J. X. Laurent, Mariem Raho, V. Chambrin, Philippe Labrune, Laure Clech, Alexandra Benachi, Bertrand Le Lorier, Isolde Pauly-Ravelly, Claude Allouche, Ama Johnson, L. Benoist, C W deLannoy, Eric Lachassine, S Bolie, J. Gaudelus, Vincent Jeantils, Amelie Benabara, Leïla Karaoui, V Lefevre, A. Bongain, Eliane Galiba, Anne Deville, Fabrice Monpoux, J. Durant, Christian Aufrant, J Furioli, Jean-Louis Salomon, Françoise Granier, Antoine Doumet, Y. Douadi, J. Gondry, J.L. Schmit, Brigitte Pautard, M. Gamerre, L. Cravello, Isabelle Thuret, Laurence Neimann, Claire Hubert, B. Carbonne, G. Vaudre, Marie‐Dominique Tabone, Catherine Dollfus, Didier Pinquier, Gaëlle Pinto Cardoso, Brigitte Clavier, F. Borsa-Lebas, Agathe de Lauzanne, Constance Borie, Sandrine Leveillé, Albert Faye, Erianna Bellaton, Dominique Garion, Martine Levine, C. Colmant, Cécile Goujard, Marc Tardieu, F. Fuchs, Ikram Jrad, Delphine Peretti, Katia Bourdic, Corinne Fourcade, Catherine Chirouze, Jean‐Marie Estavoyer, R Maillet, Véronique Reliquet, Norbert Winer, C. Brunet, Reynaud Isabelle, Claire Briandet, Jacques Brouard, Gaël Beucher, Pascale Goubin, Cécile Lanty, Eric Froguel, Béatrice Gourdel, A. Chalvon Demersay, Gilbert Algava, Véronique Hentgen, Fabienne Messaoudi, Pascale Nau, Jean‐Marc Besnier, J. Potin, Nadine Taché, Yves Bertrand, Kamila Kébaïli, Véronique Ronat, A. Frésard, Kareen Billiemaz, Ramona Abrudan, A Fournié, Jean-Marie Chennebault, Philippe Arsac, N Ciraru‐Vigneron, G Mouchnino, D Ayral, Nelly Guigue, Muriel Lalande, P Bénos, Christiane De Gennes, S. Chanzy, Valérie Isart, François Cazassus, Véronique Walter, François Bissuel, Yamina Hammou, Sophie d'Angelo, Faïza Ajana, Françoise Mazingue,
Background. Intrapartum intravenous zidovudine (ZDV) prophylaxis is a long-standing component of prevention of mother-to-child transmission (MTCT) of human immunodeficiency virus (HIV) in high-resource countries. In some recent guidelines, intravenous ZDV is no longer systematically recommended for mothers receiving combination antiretroviral therapy (cART) with low viral load. We evaluated the impact of intravenous ZDV according to viral load and obstetrical conditions. Methods. All HIV-1–infected ...
Oxford University Press
F.K. Kassi, Virginie Bellet, Adama Doumbia, Donika Krasteva, Pascal Drakulovski, Gisèle Kouakou, François Gatchitch, Éric Delaporte, Jacques Reynes, M. Mallié, Hervé Menan, Sébastien Bertout,
Cryptococcal meningitis (CM) may be caused by several species of Cryptococcus.We describe a fatal case of CM in a HIV-positive patient from Ivory Coast infected by Cryptococcus neoformans VNI and Cryptococcusdeuterogattii. Isolates were recovered from cerebrospinal fluid (CSF) prior to systemic antifungal treatment. Six isolates were studied (the entire culture plus five isolated colonies from it). Serotyping was performed via LAC 1 and CAP 64 gene amplification. Genotyping was performed using restriction ...
Tópico(s): Nail Diseases and Treatments
2016 - Microbiology Society | JMM Case Reports
Cyrille Kenne, Gisèle Mophou, René Dorville, Pascal Zongo,
This paper proposes a model for brucellosis transmission. The model takes into account the age of infection and waning immunity, that is, the progressive loss of immunity after recovery. Three routes of transmissions are considered: vertical transmission, and both direct and indirect routes of horizontal transmission. According to the well-posedness results, we provide explicit formulas for the equilibria. Next, we derive the basic reproduction number R0 and prove some stability results depending ...
Tópico(s): Mathematical and Theoretical Epidemiology and Ecology Models
2022 - Multidisciplinary Digital Publishing Institute | Mathematics
Gisèle Laguerre, Sarah M. Nour, Valérie Macheret, Juan Sanjuán, Pascal Drouin, Noëlle Amarger,
The nodC and nifH genes were characterized in a collection of 83 rhizobial strains which represented 23 recognized species distributed in the genera Rhizobium, Sinorhizobium, Mesorhizobium and Bradyrhizobium, as well as unclassified rhizobia from various host legumes. Conserved primers were designed from available nucleotide sequences and were able to amplify nodC and nifH fragments of about 930 bp and 780 bp, respectively, from most of the strains investigated. RFLP analysis of the PCR products ...
Tópico(s): Agronomic Practices and Intercropping Systems
2001 - Microbiology Society | Microbiology
ANTONIO M. VIGNOLA, Loredana Riccobono, A Mirabella, Mirella Profita, Pascal Chanez, Vincenzo Bellia, Gisèle Mautino, PROVVIDENZA D'ACCARDI, Jean Bousquet, G Bonsignore,
Asthma and chronic bronchitis are inflammatory diseases with extracellular matrix (ECM) remodeling and collagen deposition. Collagen homeostasis is controlled by metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). We evaluated MMP and TIMP balance in induced sputum of 10 control, 31 untreated asthmatic, and 16 chronic bronchitic subjects. We first performed zymographic analysis to identify the profile of MMPs. Zymography revealed a similar MMPs profile in all populations ...
Tópico(s): Cardiac Fibrosis and Remodeling
1998 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Produção Nacional
Revisado por pares
Charles H. King, Sue Binder, Ye Shen, Christopher C. Whalen, Carl H. Campbell, Ryan E. Wiegand, Annette Olsen, W. Evan Secor, Susan P. Montgomery, Rosemary Musuva, Pauline N. M. Mwinzi, Pascal Magnussen, Safari Kinung’hi, Gisele Nepomuceno de Andrade, Amara E. Ezeamama, Daniel G. Colley,
The Schistosomiasis Consortium for Operational Research (SCORE) was funded in 2008 to improve the evidence base for control and elimination of schistosomiasis—better understanding of the systemic morbidities experienced by children in schistosomiasis-endemic areas and the response of these morbidities to treatment, being essential for updating WHO guidelines for mass drug administration (MDA) in endemic areas. This article summarizes the SCORE studies that aimed to gauge the impact of MDA-based treatment ...
Tópico(s): Child Nutrition and Water Access
2020 - American Society of Tropical Medicine and Hygiene | American Journal of Tropical Medicine and Hygiene
Gisèle Laguerre, Karine Heulin‐Gotty, Brigitte Brunel, Agnieszka Klonowska, Antoine Le Queré, Pascal Tillard, Yves Prin, Jean‐Claude Cleyet‐Marel, Marc Lepetit,
• Responses of the Medicago truncatula-Sinorhizobium interaction to variation in N₂-fixation of the bacterial partner were investigated. • Split-root systems were used to discriminate between local responses, at the site of interaction with bacteria, and systemic responses related to the whole plant N status. • The lack of N acquisition by a half-root system nodulated with a nonfixing rhizobium triggers a compensatory response enabling the other half-root system nodulated with N₂-fixing partners to compensate ...
Tópico(s): Plant nutrient uptake and metabolism
2012 - Wiley | New Phytologist
Pascal Bertran, Gisèle Allenet, Christophe Fourloubey, Chantal Leroyer, Nicole Limondin‐Lozouet, Zoubida Maazouzi, Stéphane Madelaine, Jeanne Perrière, Philippe Ponel, Fabrice Casagrande, Luc Detrain,
Des dépôts alluviaux datant du Tardiglaciaire et du début de l'Holocène ont été découverts dans la plaine du Caudeau, petit affluent de la Dordogne, à La Brunetière sur la commune de Pombonne (Dordogne) à l'occasion de travaux d'archéologie préventive. Leur analyse permet de renouveler nos connaissances sur l'évolution des cours d'eau en Aquitaine pendant cette période charnière. Ils montrent en particulier que les principales phases de métamorphose alluviale décrites dans le nord de l'Europe se ...
Tópico(s): Pleistocene-Era Hominins and Archaeology
2009 - Association française pour l’étude du quaternaire | Quaternaire
Fabienne Baffert, Catherine H. Régnier, Alain De Pover, Carole Pissot‐Soldermann, Gisele Tavares, Francesca Blasco, Josef Brueggen, Patrick Chêne, Peter Drueckes, Dirk Erdmann, Pascal Furet, Marc Gerspacher, Marc Lang, David Ledieu, Lynda Nolan, Stephan Ruetz, Joerg Trappe, Eric Vangrevelinghe, Markus Wartmann, Lorenza Wyder, Francesco Hofmann, Thomas Radimerski,
The recent discovery of an acquired activating point mutation in JAK2, substituting valine at amino acid position 617 for phenylalanine, has greatly improved our understanding of the molecular mechanism underlying chronic myeloproliferative neoplasms. Strikingly, the JAK2(V617F) mutation is found in nearly all patients suffering from polycythemia vera and in roughly every second patient suffering from essential thrombocythemia and primary myelofibrosis. Thus, JAK2 represents a promising target for ...
Tópico(s): Acute Myeloid Leukemia Research
2010 - American Association for Cancer Research | Molecular Cancer Therapeutics
Gisèle Etamé Loé, Guy Pascal Ngaba, Mariette Kamdom, Emmanuel Mpondo Mpondo, Siegfried Didier Dibong,
L'objectif de l'étude a été d'évaluer les activités anti-inflammatoire et antioxydante des tiges de Phragmanthera capitata très utilisée en médecine traditionnelle. La toxicité aigüe a été réalisée selon la ligne directrice 423 de l'OCDE. L'évaluation de l'activité anti-inflammatoire suivant le modèle de l'oedème plantaire induit chez le rat par la carraghénine. La DL 50 de l'extrait au vin de palme est supérieure à 5000 mg/kg de poids corporel. L'extrait au vin de palme possède une activité anti- ...
Tópico(s): Botanical Research and Applications
2018 - African Journals OnLine | International Journal of Biological and Chemical Sciences
Gisèle Krysztofiak, Yao Té, Valéry Catoire, Gwenaël Berthet, Geoffrey C. Toon, Fabrice Jégou, Pascal Jeseck, Christian P. Robert,
Carbonyl sulphide (OCS) is an important precursor of sulphate aerosols and consequently a key species in stratospheric ozone depletion. The SPectromètre InfraRouge d'Absorption à Lasers Embarqués (SPIRALE) and shortwave infrared (SWIR) balloon-borne instruments have flown in the tropics and in the polar Arctic, and ground-based measurements have been performed by the Qualité de l'Air (QualAir) Fourier Transform Spectrometer in Paris. Partial and total columns and vertical profiles have been obtained ...
Tópico(s): Atmospheric and Environmental Gas Dynamics
2014 - Taylor & Francis | ATMOSPHERE-OCEAN
Lucie Cloix, Maxime Reverchon, Marion Cornuau, Pascal Froment, Christelle Ramé, Caroline Costa, Gisèle Froment, Pierre Lecomte, Wenyong Chen, Dominique Royère, Fabrice Guérif, Joëlle Dupont,
INTELECTIN (ITLN) is an adipokine involved in the regulation of insulin sensitivity and inflammatory and immunity responses. Serum ITLN levels are lower in obese, diabetic, and polycystic ovary syndrome (PCOS) women than in control subjects. ITLN has never been studied in ovarian cells. Here, we identified ITLN1 in human ovarian follicles and investigated the molecular mechanisms involved in the regulation of its expression in response to the insulin sensitizers metformin and rosiglitazone, in human ...
Tópico(s): Antioxidant Activity and Oxidative Stress
2014 - Oxford University Press | Biology of Reproduction
Dany Jaffuel, Pascal Demoly, C. Gougat, Patrick Balaguer, Gisèle Mautino, P. Godard, Jean Bousquet, Marc Mathieu,
Glucocorticoids (GC) are the most effective anti-inflammatory drugs used in asthma. By a process called trans-activation, they increase the transcription of genes involved in either beneficial processes or certain side effects. Through trans-repression, they inhibit the transcription factors nuclear factor kappa B (NF- κ B) and activator protein-1 (AP-1), thereby decreasing the expression of many genes encoding inflammatory mediators such as the cytokine RANTES. We have measured the trans-activation ...
Tópico(s): Asthma and respiratory diseases
2000 - American Thoracic Society | American Journal of Respiratory and Critical Care Medicine
Cyrille Kenne, René Dorville, Gisèle Mophou, Pascal Zongo,
Tópico(s): Viral Infections and Vectors
2021 - Springer Science+Business Media | Bulletin of Mathematical Biology
Pierre Frange, Roland Tubiana, Jeanne Sibiude, Ana Canestri, C. Arvieux, Cécile Brunet-Cartier, Laurent Cotte, Jacques Reynes, Laurent Mandelbrot, Josiane Warszawski, Jérôme Le Chenadec, Laurent Mandelbrot, C. Crenn-Hébert, Corinne Floch-Tudal, Fabienne Mazy, Marine Joras, Françoise Meier, Emmanuel Mortier, Catherine Briquet, Houria Ichou, Laurence Marty, Hélène Jabbarian, Pierre‐François Ceccaldi, Agnès Villemant, Virginie Zarouk, A. Lefort, M Salah, Gilles Hittinger, Jean-Marc Chamouilli, Christian Burle, Alain Lafeuillade, Gisèle Philip, Véronique Lambry, Marie Medus, Germaine Bachelard, Martine Malet, Joëlle Dendale-Nguyen, Thomas Guimard, Karine Guimard, Jean-Pierre Brossier, Philippe Van de Perre, Jean-Luc Esnault, Olivier Aubry, Sophie Leautez-Nainville, Valerie Bonnenfant, Laeticia Laine, Sandrine-Anne Martha, E. Maurel, Michel Françoise, Muriel Barat, Patricia Murger, Mahfoud Rouha, Marc Lévy, P Lumbroso, A Checoury, Osseni Sahadatu, Ama Johnson, Pascale Perfezou, Gilles Blondin, Jean-Charles Duthé, Séverine Ansart, Luc de Saint Martin, Philippe Le Moine, Jean-Charles Duthé, Corinne Daniel, Christian Calvez, Emmanuelle Boutaric, Jennifer Rohan, Cédric Arvieux, Estelle Bauville, Christelle Dupre, Pascal Lotton, Enora Ouamara-digue, Yves Poinsignon, Marie Goussef, Anne Grelier, Gaétane Mousset, Corinne Cudeville, Virginie Mouton-Rioux, Mathilde Niault, Isabelle Belzic, Philippe Moreau, Marie-Françoise Le Coz, Odile Luycx Vaillant, Anne Guerin-Duplessy, Virginie Mouton-Rioux, Philippe De Morel, Virginie Vitrat, Didier Tardif, Jacques Gaillat, Anne Vanderbergh, Suzanne Braig, Gaëlle Clavere, Marion Dehlinger-Paul, Khaled Mohamed, Marie Echard, Michel Camus, Catherine Mulard, Marie-Agnès Fontelonga, Brigitte Heller-Roussin, Cécile Winter, Marion Challier, Elise Debruyne, Valérie Marcou, Ghislaine Firtion, E. Pannier, Myriam Costa, Odile Launay, Dominique Salmon‐Céron, Touria Belkacem, Youcef Bajawi, Valérie Raynal Aubret, Danièle Rivaux, Sophie Matheron, Neila Elaoun, Lahcene Allal, Sandrine Djoubou, Djamila Rahli, Agnès Bourgeois Moine, M. Valentin, Florence Damond, Virginie Huri, Valérie Vivier, Fatma Ait Yahia, Valérie Garrait, Isabelle Hau, Claudine Touboul, Lanto Ratsimbazafy, Emilie Boiron, Brigitte Elharrar, Laurent Richier, Laurent Cotte, Jean-Marc Labaune, R.-C. Rudigoz, C. Brochier, Valérie Galvan, Stanislas Ogoudjobi, Christophe Elleau, Camille Runel-Belliard, Thierry Pistone, Hervé Fleury, Jacques Horovitz, Boris Sandler, Denis Roux, Jean-Marie Ragnaud, P. Chabanier, Jean-Luc Brun, Sandrine Delveaux, Blandine Muanza, Mama Doufari Diallo, Isabelle Lamaury, Marie-Thérèse Sow, Ketty Samar, Bénédicte Carpentier, Zafer Osman, Etienne Dienga, Hervé Seaume, Sarah Ducrocq, Philippe Bailly-Salin, Christelle Dusart Da Silva, Isabelle Fayolas, Julie Abbal, Caroline Simon-Toulza, Véronique Truillet, Noëlle Bogner, Julie Chiabrando, Evelyne Armand, Claudine Cayla, Anne Chacé, Sophie Matheron, Laurent Richier, Joe Miantezila, Sandrine Bry, Sophie Couderc, C. Narcy, Corinne Routier, Rania Nassar, Marie‐Anne Bouldouyre, Ahmed S. Zakaria, Hélène Dauphin, Céline Goissen, Marie Belloy, Jean-Luc Delassus, Véronique Favret, Céline Nemeth, MariaLuisa Partisani, Natacha Entz‐Werlé, Bruno Langer, F. Uettwiller, Myriam Durand, MariaLuisa Partizani, Christine Cheneau, David Rey, Edith Ebel, Patricia Fischer, Éric David, Christophe Vayssière, Michèle Weil, Marie Paule Schmitt, I. Nisand, Philippe Genet, Dominique Brault, C Allisy, Juliette Gerbe, Virginie Masse, Bouchra Wifaq, Laurence Courdavault, P Gábor, Nathalie Tordjeman, Marie-Gisèle Lebrette, Lise Selleret, Déborah Samama, Geneviève Vaudre, Pascal Bolot, Marie-Aude Khuong-Josses, Mahdi Amel, S. Bounan, Christelle Nourry, Sabine Andris, Stéphane Blanche, Marine Driessen, Pierre Frange, Florence Veber, Alain Fischer, Christine Rouzioux, Véronique Avettand-Fènoël, Nizar Mahlaoui, Marie-Christine Mourey, Michèle Granier, Alain Devidas, Anne-Claire Donnadieu, Adrien May, Amélie Chabrol, Pierre Chevojon, Chahrazede Bellahcene, Audrey Sanchez, C Malbrunot, Joelle Neizelien, Nouara Agher, Claire Pluchart, Christine Rouger, Roland Tubiana, Marc Dommergues, Manuela Bonmarchand, Luminata Shneider, Fabienne Caby, Ruxandra-Oana Calin, C Blanc, Catherine Lupin, Michèle Pauchard, Mohamed Amine Yangui, Didier Roca, Darina Todorova, J. X. Laurent, Arnaud Ferry, Martine Deschaud, L. Blum, V. Chambrin, Philippe Labrune, Laure Clech, Mariem Raho-Moussa, Isolde Pauly-Ravelly, Thierry Jault, Soufiane Bouabdallah, Lydie Sanchez, Anita Sanchez, Ama Johnson, Agnès Louchard, Claude Allouche, Jean-Paul Pathe, Eric Lachassine, L. Benoist, Vincent Jeantils, C W deLannoy, Amélie Benbara, Lionel Carbillon, Anne Borgne, Laurence Moreau, Fabienne Picard, Leïla Karaoui, Véronique Lefevre Elbert, Valérie Balaz, A. Bongain, Fabrice Monpoux, Anne Deville, Eliane Galiba, A S Abdul Jabbar, Martine Joutel, Jean-Luc Schmidt, Nathalie Decaux, L. Cravello, Katia Errichiello, Claire Hubert, Catherine Dollfus, François Hervé, Marie‐Dominique Tabone,
Safety data about rilpivirine use during pregnancy remain scarce, and rilpivirine plasma concentrations are reduced during second/third trimesters, with a potential risk of viral breakthroughs. Thus, French guidelines recommend switching to rilpivirine-free combinations (RFCs) during pregnancy.To describe the characteristics of women initiating pregnancy while on rilpivirine and to compare the outcomes for virologically suppressed subjects continuing rilpivirine until delivery versus switching to ...
Oxford University Press
Jean‐Pierre Monthéard, Gisèle Boiteux, B. Thémans, Jean‐Luc Brédas, Thierry Pascal, G. Froyer,
Abstract The theoretical electronic characteristics of two conjugated regular copolymers, poly(1,4-phenylene-2′,5′-thienylene) (PT 2–5) and poly(1,4-phenylene-2′,6′-pyridinediyl) (PP 2–6), were determined using the valence effective Hamiltonian (VEH) method. The VEH method allows one to calculate ionization potential, bandgap, bandwidth and electron affinity in relation to the molecular composition and geometry of the polymeric repeating unit. The crystalline organization of the two copolymers was ...
Tópico(s): Advanced Sensor and Energy Harvesting Materials
1990 - Elsevier BV | Synthetic Metals
Pascal Zongo, Malicki Zorom, Gisèle Mophou, René Dorville, Catherine Beaumont,
Abstract The main objective of this paper is to address the following question: are the containment measures imposed by most of the world governments effective and sufficient to stop the epidemic of COVID-19 beyond the lock-down period? In this paper, we propose a mathematical model which allows us to investigate and analyse this problem. We show by means of the reproductive number, ${\cal R}_0$ that the containment measures appear to have slowed the growth of the outbreak. Nevertheless, these measures ...
Tópico(s): SARS-CoV-2 and COVID-19 Research
2020 - Cambridge University Press | Epidemiology and Infection