Sara Cheleschi, Nicola Antonio Pascarelli, Giuseppe Valacchi, Angela Di Capua, Mariangela Biava, Giuseppe Belmonte, Antonio Giordani, Claudia Sticozzi, Maurizio Anzini, Antonella Fioravanti,
VA694, a promising cyclooxigenase-2 (COX-2)-inhibiting hybrid drug endowed with nitric oxide (NO) releasing properties (NO-COXIB), showed COX-2-selective inhibitory effects, associated with interesting anti-inflammatory and anti-nociceptive activities. Therefore, we studied the effects of VA694 on cartilage metabolism, in comparison with Naproxcinod, a COX inhibitor and NO donor (CINOD), and Naproxen, a traditional non-steroidal-anti-inflammatory drug (NSAID) on human osteoarthritic chondrocyte cultures. ...
Tópico(s): NF-κB Signaling Pathways
2015 - Elsevier BV | International Immunopharmacology
Andrea Nicolini, Angelo Carpi, Paola Ferrari, Pier Mario Biava, Giuseppe Rossi,
Historically, antiestrogen is the first targeted therapy used in breast cancer treatment. In fact, its rationale lies in the molecular pathways elucidated by basic research. In estrogen receptor (ER)-alpha positive metastatic breast cancer patients, hormone-therapy remains the first option of treatment. While tamoxifen concomitant with suppression of ovarian function with luteinizing hormone releasing hormone (LHRH) agonists is the standard first line treatment in premenopausal, third generation aromatase ...
Tópico(s): Immunotherapy and Immune Responses
2016 - Bentham Science Publishers | Current Drug Targets
Pierangelo Chinello, Nicola Petrosillo, Silvia Pittalis, Gianluigi Biava, Giuseppe Ippolito, Emanuele Nicastri,
Tópico(s): Influenza Virus Research Studies
2017 - Public Library of Science | PLoS neglected tropical diseases
Claudia Sticozzi, Giuseppe Belmonte, Franco Cervellati, Angela Di Capua, Emanuela Maioli, Andrea Cappelli, Antonio Giordani, Mariangela Biava, Maurizio Anzini, Giuseppe Valacchi,
Selective COX-2 inhibitors (COXib) belonging to the class of diaryl heterocycles (e.g., celecoxib, rofecoxib, etc.), are devoid of the undesirable effects due to their capacity to inhibit selectively inducible (COX-2), responsible for inflammatory effects but not constitutive cyclooxygenase-1 (COX-1)(COX); responsible for cytoprotective effects on gastric mucosa. In addition, several reports have identified an increased risk of cardiovascular events associated with the use of COXib. We have developed ...
Tópico(s): Synthesis and Reactions of Organic Compounds
2013 - Elsevier BV | European Journal of Pharmaceutical Sciences
Andrea Nicolini, Vivian Barak, Piermario Biava, Paola Ferrari, Giuseppe Rossi, Angelo Carpi,
This article reviews the principal attempts of immune-modulation or immune therapy in metastatic breast cancer. It considers their rationale and reports on results from the relevant key clinical trials. Immune-modulatory or immune-stimulating cytokines used alone or combined with conventional therapies is among the principal approaches of immune manipulation in breast cancer. As this issue has recently been reviewed by us, the aim of the current article is to discuss our updated and unpublished ...
Tópico(s): Immunotherapy and Immune Responses
2018 - Bentham Science Publishers | Current Medicinal Chemistry
Andrea Nicolini, Paola Ferrari, Lucie Kotlarova, Giuseppe Rossi, Pier Mario Biava,
Acquired hormone resistance is an old hurdle and still represents to be a constant challenge in oncology for the medical community. Most recently, mainly following the results of BOLERO-2 study, the activation of the PI3K-AKT-mTOR pathway is considered clinically relevant for tumor escape from hormone dependence in breast cancer. In the BOLERO-2 trial, a combination of everolimus, mTOR inhibitor, and exemestane significantly prolonged the median progression free survival (PFS) compared to exemestane ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2015 - Bentham Science Publishers | Current Pharmaceutical Biotechnology
Simone Lanini, Gina Portella, Francesco Vairo, Gary Kobinger, Antonio Pesenti, Martin Langer, Soccoh Kabia, Giorgio Brogiato, Jackson Amone, Concetta Castilletti, Rossella Miccio, Maria Rosaria Capobianchi, Gino Strada, Alimuddin Zumla, Antonino Di, Giuseppe Ippolito, Mirella Biava, Angela Cannas, Roberta Chiappini, Sabrina Coen, Francesca Colavita, Germana Grassi, Daniele Lapa, Antonio Mazzarelli, Silvia Meschi, Claudia Minosse, Serena Quartu, Maria Beatrice Valli, Carolina Venditti, Antonella Vulcano, Paola Zaccaro, Umar Ahmad, Elisabetta Checcarelli, Michela Delli Guanti, Elena Giovanella, Davide Gottardello, Maurizio Guastalegname, Milos Jocic, Giorgio Monti, Clare Parsons, Nicola De Rossi, Giampiero Salvati, Giovanna Scaccabarozzi, Erminio Sisillo, Paola Tagliabue, Marta Turella, Caterina Valdatta,
Pathogenesis of Ebola virus disease remains poorly understood. We used concomitant determination of routine laboratory biomarkers and Ebola viremia to explore the potential role of viral replication in specific organ damage.We recruited patients with detectable Ebola viremia admitted to the EMERGENCY Organizzazione Non Governativa Organizzazione Non Lucrativa di Utilità Sociale (ONG ONLUS) Ebola Treatment Center in Sierra Leone. Repeated measure of Ebola viremia, alanine aminotransferase (ALT), aspartate ...
Tópico(s): Disaster Response and Management
2017 - Oxford University Press | Clinical Infectious Diseases
Luca Durelli, Bruno Ferrero, Alessandra Oggero, E. Verdun, Maria Roberta Bongioanni, Eleonora Gentile, G. Isoardo, Alessia Andrea Ricci, Eugenia Rota, B. Bergamasco, Marilena Durazzo, Giorgio Maria Saracco, Mirella Biava, P.C. Brossa, Laura M. Giorda, Roberto Pagni, Giuseppe Aimo,
Autoimmune events, although rarely reported during interferon beta-1b (IFNB) treatment of relapsing–remitting (RR) multiple sclerosis (MS), may be more frequent than expected due to the many immunologic abnormalities associated with this disease. We report the prospective two-year follow-up of autoimmune events in 40 RR MS patients treated with IFNB and in 21 untreated MS controls. Thyroid and liver function and serum level of 12 autoantibodies (autoAbs) against organ- (thyroid, gastric, pancreatic) ...
Tópico(s): Liver Diseases and Immunity
1999 - Elsevier BV | Journal of the Neurological Sciences
Francesca Colavita, Veronica Bordoni, Claudia Caglioti, Mirella Biava, Concetta Castilletti, Licia Bordi, Serena Quartu, Marco Iannetta, Giuseppe Ippolito, Chiara Agrati, Maria Rosaria Capobianchi, Eleonora Lalle,
The recent epidemic in the Americas caused by Zika virus (ZIKV), Asian lineage, spurred the research towards a better understanding of how ZIKV infection affects the host immune response. The aim of this study was to evaluate the effects of Asian and East African ZIKV strain infection on the induction of IFN and proinflammatory and Th2 cytokines in human PBMC. We reported a slight modulation of type II IFN in PBMC exposed to Asian strain, but not to African strain, and a complete lack of type I and ...
Tópico(s): COVID-19 epidemiological studies
2018 - Hindawi Publishing Corporation | Mediators of Inflammation
Laura Falasca, Roberta Nardacci, Daniele Colombo, Eleonora Lalle, Antonino Di, Emanuele Nicastri, Andrea Antinori, Nicola Petrosillo, Luisa Marchioni, Gianluigi Biava, Gianpiero D’Offizi, Fabrizio Palmieri, Delia Goletti, Alimuddin Zumla, Giuseppe Ippolito, Mauro Piacentini, Franca Del Nonno,
Abstract Background Descriptions of the pathological features of coronavirus disease-2019 (COVID-19) caused by the novel zoonotic pathogen severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) emanate from tissue biopsies, case reports, and small postmortem studies restricted to the lung and specific organs. Whole-body autopsy studies of COVID-19 patients have been sparse. Methods To further define the pathology caused by SARS-CoV-2 across all body organs, we performed autopsies on 22 patients ...
Tópico(s): COVID-19 and healthcare impacts
2020 - Oxford University Press | The Journal of Infectious Diseases
Francesca Colavita, Mirella Biava, Concetta Castilletti, Simone Lanini, Rossella Miccio, Gina Portella, Francesco Vairo, Giuseppe Ippolito, Maria Rosaria Capobianchi, Antonino Di, Eleonora Lalle,
Ebola virus (EBOV) infection is characterized by an excessive inflammatory response, a loss of lymphocytes and a general paralysis of the immune system, however pathophysiological mechanisms are not fully understood. In a cohort of 23 fatal and 21 survivors of ebola virus disease (EVD) cases admitted to the Emergency Ebola-Treatment-Center in Goderich (Freetown, Sierra Leone) during the 2014 to 2016 EBOV epidemic in Western Africa, we analyzed the pathway-focused gene expression profile of secreted ...
Tópico(s): COVID-19 epidemiological studies
2019 - Multidisciplinary Digital Publishing Institute | Viruses
Francesca Colavita, Mirella Biava, Concetta Castilletti, Simone Lanini, Rossella Miccio, Gina Portella, Francesco Vairo, Giuseppe Ippolito, Maria Rosaria Capobianchi, Antonino Di, Eleonora Lalle,
Ebola virus (EBOV) infection is characterized by an excessive inflammatory response, a loss of lymphocytes and a general paralysis of the immune system, however pathophysiological mechanisms are not fully understood. In a cohort of 23 fatal and 21 survivors of ebola virus disease (EVD) cases admitted to the Emergency Ebola-Treatment-Center in Goderich (Freetown, Sierra Leone) during the 2014 to 2016 EBOV epidemic in Western Africa, we analyzed the pathway-focused gene expression profile of secreted ...
Tópico(s): Respiratory viral infections research
1961 - | VIRUS
Pier Mario Biava, Fabio Burigana, Roberto Germano, Philip Kurian, C. Verzegnassi, Giuseppe Vitiello,
A long history of research has pursued the use of embryonic factors isolated during cell differentiation processes for the express purpose of transforming cancer cells back to healthy phenotypes. Recent results have clarified that the substances present at different stages of cell differentiation-which we call stem cell differentiation stage factors (SCDSFs)-are proteins with low molecular weight and nucleic acids that regulate genomic expression. The present review summarizes how these substances, ...
Tópico(s): Molecular Communication and Nanonetworks
2018 - Bentham Science Publishers | Current Medicinal Chemistry
Massimo Ferretti, Marco Gattorno, Annalisa Chiocchetti, Riccardo Mesturini, Elisabetta Orilieri, Thea Bensi, Maria Pia Sormani, Giuseppe Cappellano, Elisa Cerutti, Stefania Nicola, A. Biava, Claudio Bardelli, Silvia Federici, Isabella Ceccherini, Maurizia Baldi, Claudio Santoro, Irma Dianzani, Alberto Martini, Umberto Dianzani,
Abstract Objective Hereditary periodic fever syndromes (HPFs) develop as a result of uncontrolled activation of the inflammatory response, with a substantial contribution from interleukin‐1β or tumor necrosis factor α (TNFα). The HPFs include familial Mediterranean fever (FMF), hyperimmunoglobulinemia D with periodic fever syndrome (HIDS), TNF receptor–associated syndrome (TRAPS), and cryopyrinopathies, which are attributable to mutations of the MEFV , MVK , TNFRSF1A , and CIAS1 genes, respectively. However, ...
Tópico(s): Cancer-related molecular mechanisms research
2009 - Wiley | Arthritis & Rheumatism
Irma Dianzani, Luisa Gibello, A. Biava, Mara Giordano, Marinella Bertolotti, Marta Betti, Daniela Ferrante, Simonetta Guarrera, G.P. Betta, Dario Mirabelli, Giuseppe Matullo, Corrado Magnani,
Differences in response to carcinogenic agents are due to the allelic variants of the genes that control it. Key genes are those involved in the repair of the DNA damage caused by such agents. This paper describes the results of a case-control epidemiological study designed to determine the genotypes of four of these genes in persons exposed to a single genotoxic factor, i.e. asbestos, who had or had not developed malignant mesothelioma (MM). Our working hypothesis was that an imperfect DNA repair, ...
Tópico(s): Occupational and environmental lung diseases
2006 - Elsevier BV | Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
Umberto Anceschi, Gabriele Tuderti, Franco Lugnani, Pier Mario Biava, G. Malossini, Lorenzo Luciani, Tommaso Cai, Davide Marsiliani, Alessio Filianoti, Daniele Mattevi, Manuela Costantini, Leonardo Misuraca, Giuseppe Simone,
In recent years, several biomarkers alternative to standard prostate specific antigen (PSA) for prostate cancer (PCa) diagnosis have become available. The aim of this systematic review is to assess the current knowledge about alternative serum and urinary biomarkers for the diagnosis of PCa.A research was conducted in Medline, restricted to English language articles published between December 2014 and June 2018 with the aim to update previously published series on PCa biomarkers. The preferred reporting ...
Tópico(s): Circular RNAs in diseases
2018 - Bentham Science Publishers | Current Medicinal Chemistry
Franco Lugnani, Giuseppe Simone, Pier Mario Biava, Richard J. Ablin,
Neuroendocrine prostate carcinoma (NE-PCa) is a heterogeneous disease. Due to a high prevalence of NE (neuroendocrine) differentiation in patients who receive prolonged androgen deprivation treatment, the real incidence of NE-PCa remains unknown. Similarly, the biological steps from prostate carcinoma (PCa) toward NE differentiation are far less than definitive and, consequently, there is a lack of evidence to support any of the treatments as the "gold standard". Materials and Methods: A systematic ...
Tópico(s): Lung Cancer Research Studies
2014 - Bentham Science Publishers | Current Medicinal Chemistry
Emanuele Nicastri, Antonio Brucato, Nicola Petrosillo, Gianluigi Biava, Timothy M. Uyeki, Giuseppe Ippolito,
During the 2013–2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA. In May 2015, a 37-year old male nurse contracted Ebola virus disease in Sierra Leone. After Ebola virus detection in plasma, he was medically-evacuated to Italy. At admission, rhabdomyolysis was clinically and laboratory-diagnosed and was treated with aggressive hydration, oral favipiravir and intravenous investigational monoclonal antibodies against ...
Tópico(s): Viral Infections and Vectors
2017 - BioMed Central | BMC Infectious Diseases
Angela Di Capua, Claudia Sticozzi, Simone Brogi, Margherita Brindisi, Andrea Cappelli, Lidia Sautebin, Antonietta Rossi, Simona Pace, Carla Ghelardini, Lorenzo Di Cesare Mannelli, Giuseppe Valacchi, Gianluca Giorgi, Antonio Giordani, Giovanna Poce, Mariangela Biava, Maurizio Anzini,
A series of substituted 1,5-diarylpyrrole-3-alkoxyethyl ethers were previously synthesized and the potential anti-inflammatory and antinociceptive activities of these compounds were evaluated in vivo. The compounds displayed a very good activity against both carrageenan-induced hyperalgesia and oedema in the rat paw test. Therefore, in a very preliminary test, compounds (8a,b) showed antiproliferative activity in the HaCaT (aneuploid immortal keratinocyte from adult human skin) cell models. On these ...
Tópico(s): Fluorine in Organic Chemistry
2015 - Elsevier BV | European Journal of Medicinal Chemistry
Giuseppe Sberna, Marco Biagi, Giovanni Marafini, Roberta Nardacci, Mirella Biava, Francesca Colavita, Pierluca Piselli, Elisabetta Miraldi, Gianpiero D’Offizi, Maria Rosaria Capobianchi, Alessandra Amendola,
Except for specific vaccines and monoclonal antibodies, effective prophylactic or post-exposure therapeutic treatments are currently limited for COVID-19. Propolis, a honeybee's product, has been suggested as a potential candidate for treatment of COVID-19 for its immunomodulatory properties and for its powerful activity against various types of viruses, including common coronaviruses. However, direct evidence regarding the antiviral activities of this product still remains poorly documented. VERO ...
Tópico(s): Phytochemicals and Antioxidant Activities
2022 - Frontiers Media | Frontiers in Microbiology
Francesca Colavita, Mirella Biava, Concetta Castilletti, Serena Quartu, Francesco Vairo, Claudia Caglioti, Chiara Agrati, Eleonora Lalle, Licia Bordi, Simone Lanini, Michela Delli Guanti, Rossella Miccio, Giuseppe Ippolito, Maria Rosaria Capobianchi, Antonino Di,
Abstract The recent Ebola outbreak in West Africa caused breakdowns in public health systems, which might have caused outbreaks of vaccine-preventable diseases. We tested 80 patients admitted to an Ebola treatment center in Freetown, Sierra Leone, for measles. These patients were negative for Ebola virus. Measles virus IgM was detected in 13 (16%) of the patients.
Tópico(s): Disaster Response and Management
2017 - Centers for Disease Control and Prevention | Emerging infectious diseases
Beatrice Bassetti, Corrado Carbucicchio, Valentina Catto, Elisa Gambini, Erica Rurali, A. Bestetti, Giuseppe Gaipa, Daniela Belotti, Fabrizio Celeste, Matteo Parma, Stefano Righetti, Lorenza Biava, Maurizio Arosio, Alice Bonomi, Piergiuseppe Agostoni, Paolo Scacciatella, Felice Achilli, Giulio Pompilio,
Cell therapy with bone marrow (BM)-derived progenitors has emerged as a promising therapeutic for refractory angina (RA) patients. In the present study, we evaluated the safety and preliminary efficacy of transcatheter delivery of autologous BM-derived advanced therapy medicinal product CD133+ cells (ATMP-CD133) in RA patients, correlating perfusion outcome with cell function. In the phase I "Endocavitary Injection of Bone Marrow Derived CD133+ Cells in Ischemic Refractory Cardiomyopathy" (RECARDIO) ...
Tópico(s): Cardiac Fibrosis and Remodeling
2018 - BioMed Central | Stem Cell Research & Therapy
Mirella Biava, Claudia Caglioti, Licia Bordi, Concetta Castilletti, Francesca Colavita, Serena Quartu, Emanuele Nicastri, F. Lauria, Nicola Petrosillo, Simone Lanini, Thomas Hoenen, Gary Kobinger, Alimuddin Zumla, Antonino Di, Giuseppe Ippolito, Maria Rosaria Capobianchi, Eleonora Lalle,
An unprecedented Ebola virus (EBOV) epidemic occurred in 2013-2016 in West Africa. Over this time the epidemic exponentially grew and moved to Europe and North America, with several imported cases and many Health Care Workers (HCW) infected. Better understanding of EBOV infection patterns in different body compartments is mandatory to develop new countermeasures, as well as to fully comprehend the pathways of human-to-human transmission. We have longitudinally explored the persistence of EBOV-specific ...
Tópico(s): Viral gastroenteritis research and epidemiology
2017 - Public Library of Science | PLoS Pathogens
Eleonora Lalle, Mirella Biava, Emanuele Nicastri, Francesca Colavita, Antonino Di, Francesco Vairo, Simone Lanini, Concetta Castilletti, Martin Langer, Alimuddin Zumla, Gary Kobinger, Maria Rosaria Capobianchi, Giuseppe Ippolito,
Filoviruses have become a worldwide public health concern, especially during the 2013–2016 Western Africa Ebola virus disease (EVD) outbreak—the largest outbreak, both by number of cases and geographical extension, recorded so far in medical history. EVD is associated with pathologies in several organs, including the liver, kidney, and lung. During the 2013–2016 Western Africa outbreak, Ebola virus (EBOV) was detected in the lung of infected patients suggesting a role in lung pathogenesis. However, ...
Tópico(s): Disaster Response and Management
2019 - Multidisciplinary Digital Publishing Institute | Viruses
Irma Dianzani, Marta Betti, Mirella Giordano, Marco Bertolotti, A. Biava, Daniela Ferrante, Simonetta Guarrera, G.P. Betta, Dario Mirabelli, Giuseppe Matullo, Corrado Magnani,
Tópico(s): Occupational and environmental lung diseases
2006 - Elsevier BV | Lung Cancer
Rossella Fioravanti, Mariangela Biava, Giulio Cesare Porretta, Salvatore Foti, Giuseppe Musumarra, Rosaria Saletti,
Tópico(s): Muon and positron interactions and applications
1994 - Elsevier BV | Heterocycles
Francesca Colavita, Mirella Biava, Pascal Mertens, Quentin Gilleman, Céline Borlon, Michela Delli Guanti, A. Petrocelli, G. Cataldi, A. Kamara, Sarian Kamara, Kelfala Konneh, Donatella Vincenti, Concetta Castilletti, Samir Abdurahman, Alì Mirazimi, Maria Rosaria Capobianchi, Giuseppe Ippolito, Rossella Miccio, Antonino Di,
Efficient interruption of Ebola virus disease (EVD) transmission chains critically depends on reliable and fast laboratory diagnosis. We evaluated the performance of the EBOLA Virus Antigen Detection K-SeT (EBOLA Ag K-SeT), a new rapid diagnostic antigen test in field settings.The study was conducted in a field laboratory located in Freetown (Sierra Leone) by the Italian National Institute for Infectious Diseases 'L. Spallanzani' and the EMERGENCY Onlus NGO. The EBOLA Ag K-SeT was tested on 210 residual ...
Tópico(s): Viral Infections and Vectors
2017 - Elsevier BV | Clinical Microbiology and Infection
Francesca Colavita, Daniele Lapa, Fabrizio Carletti, Eleonora Lalle, Francesco Messina, Martina Rueca, Giulia Matusali, Silvia Meschi, Licia Bordi, Patrizia Marsella, Emanuele Nicastri, Luisa Marchioni, Andrea Mariano, Laura Scorzolini, Tommaso Ascoli Bartoli, Antonino Di, Giuseppe Ippolito, Maria Rosaria Capobianchi, Concetta Castilletti, Isabella Abbate, Chiara Agrati, Loredana Aleo, Tonino Alonzi, Alessandra Amendola, Claudia Apollonio, Nicolina Arduini, Barbara Bartolini, Giulia Berno, Silvia Biancone, Mirella Biava, Angela Bibbò, Licia Bordi, Carla Brega, Marco Canali, Angela Cannas, Maria Rosaria Capobianchi, Fabrizio Carletti, Stefania Carrara, Rita Casetti, Concetta Castilletti, Roberta Chiappini, Lucia Ciafrone, Eleonora Cimini, Sabrina Coen, Francesca Colavita, Rossella Condello, Antonio Coppola, Silvia D’Arezzo, Antonino Di, Stefania Di Filippo, Chiara Di Giuli, Lavinia Fabeni, Luisa Felici, Valeria Ferraioli, Federica Forbici, Anna Rosa Garbuglia, Emanuela Giombini, Caterina Gori, Silvia Graziano, Cesare Ernesto Maria Gruber, Daniele Khouri, Eleonora Lalle, Daniele Lapa, Barbara Leone, Patrizia Marsella, Chiara Massimino, Giulia Matusali, Antonio Mazzarelli, Silvia Meschi, Francesco Messina, Claudia Minosse, Claudia Montaldo, Stefania Neri, Carla Nisii, Elisabetta Petrivelli, Fabrizio Petroni, Elisa Petruccioli, Marina Pisciotta, Daniele Pizzi, Gianluca Prota, Fabrizio Raparelli, Gabriella Rozera, Martina Rueca, Rossella Sabatini, Silvia Sarti, Giuseppe Sberna, Roberta Sciamanna, Marina Selleri, Carla Selvaggi, Catia Sias, Chiara Stellitano, Antonietta Toffoletti, Silvia Truffa, Federica Turchi, Maria Beatrice Valli, Carolina Venditti, Tiziana Vescovo, Donatella Vincenti, Antonella Vulcano, Emma Zambelli, Maria Alessandra Abbonizio, Chiara Agrati, Fabrizio Albarello, Gioia Amadei, Alessandra Amendola, Mario Antonini, Maria Raffaella Barbaro, Barbara Bartolini, Martina Benigni, Nazario Bevilacqua, Licia Bordi, Veronica Bordoni, Marta Branca, Paolo Campioni, Maria Rosaria Capobianchi, Cinzia Caporale, Ilaria Caravella, Fabrizio Carletti, Concetta Castilletti, Roberta Chiappini, Carmine Ciaralli, Francesca Colavita, Angela Corpolongo, Massimo Cristofaro, Salvatore Curiale, Alessandra D’Abramo, Cristina Dantimi, Alessia De Angelis, Giada De Angelis, Rachele Di Lorenzo, Federica Di Stefano, Federica Ferraro, Lorena Fiorentini, Andrea Frustaci, Paola Gallì, Gabriele Garotto, Maria Letizia Giancola, Filippo Giansante, Emanuela Giombini, Maria Cristina Greci, Giuseppe Ippolito, Eleonora Lalle, Simone Lanini, Daniele Lapa, Luciana Lepore, Andrea Lucía, Franco Lufrani, Manuela Macchione, Alessandra Marani, Luisa Marchioni, Andrea Mariano, Maria Cristina Marini, Micaela Maritti, Giulia Matusali, Silvia Meschi, Francesco Messina, Chiara Montaldo, Silvia Murachelli, Emanuele Nicastri, Roberto Noto, Claudia Palazzolo, Emanuele Pallini, Virgilio Passeri, Federico Pelliccioni, Antonella Petrecchia, Ada Petrone, Nicola Petrosillo, Elisa Pianura, Maria Pisciotta, Silvia Pittalis, Costanza Proietti, Vincenzo Puro, Gabriele Rinonapoli, Martina Rueca, Alessandra Sacchi, Francesco Sanasi, Carmen Santagata, Silvana Scarcia, Vincenzo Schininà, Paola Scognamiglio, Laura Scorzolini, Giulia Valeria Stazi, Francesco Vaia, Francesco Vairo, Maria Beatrice Valli, Isabella Abbate, Chiara Agrati, Loredana Aleo, Tonino Alonzi, Alessandra Amendola, Claudia Apollonio, Nicolina Arduini, Barbara Bartolini, Giulia Berno, Silvia Biancone, Mirella Biava, Angela Bibbò, Licia Bordi, Carla Brega, Marco Canali, Angela Cannas, Maria Rosaria Capobianchi, Fabrizio Carletti, Stefania Carrara, Rita Casetti, Concetta Castilletti, Roberta Chiappini, Lucia Ciafrone, Eleonora Cimini, Sabrina Coen, Francesca Colavita, Rossella Condello, Antonio Coppola, Silvia D’Arezzo, Antonino Di, Stefania Di Filippo, Chiara Di Giuli, Lavinia Fabeni, Luisa Felici, Valeria Ferraioli, Federica Forbici, Anna Rosa Garbuglia, Emanuela Giombini, Caterina Gori, Silvia Graziano, Cesare Ernesto Maria Gruber, Daniele Khouri, Eleonora Lalle, Daniele Lapa, Barbara Leone, Patrizia Marsella, Chiara Massimino, Giulia Matusali, Antonio Mazzarelli, Silvia Meschi, Francesco Messina, Claudia Minosse, Claudia Montaldo, Stefania Neri, Carla Nisii, Elisabetta Petrivelli, Fabrizio Petroni, Elisa Petruccioli, Marina Pisciotta, Daniele Pizzi, Gianluca Prota, Fabrizio Raparelli, Gabriella Rozera, Martina Rueca, Rossella Sabatini, Silvia Sarti, Giuseppe Sberna, Roberta Sciamanna, Marina Selleri, Carla Selvaggi, Catia Sias, Chiara Stellitano, Antonietta Toffoletti, Silvia Truffa, Federica Turchi, Maria Beatrice Valli, Carolina Venditti, Tiziana Vescovo, Donatella Vincenti, Antonella Vulcano, Emma Zambelli, Maria Alessandra Abbonizio, Chiara Agrati, Fabrizio Albarello, Gioia Amadei, Alessandra Amendola, Mario Antonini, Maria Raffaella Barbaro, Barbara Bartolini, Martina Benigni, Nazario Bevilacqua, Licia Bordi, Veronica Bordoni, Marta Branca, Paolo Campioni, Maria Rosaria Capobianchi, Cinzia Caporale, Ilaria Caravella, Fabrizio Carletti, Concetta Castilletti, Roberta Chiappini, Carmine Ciaralli, Francesca Colavita, Angela Corpolongo, Massimo Cristofaro, Salvatore Curiale, Alessandra D’Abramo, Cristina Dantimi, Alessia De Angelis, Giada De Angelis, Rachele Di Lorenzo,
The pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remains unclear. We report the detection of viral RNA from different anatomical districts and the antibody profile in the first 2 COVID-19 cases diagnosed in Italy.We tested for SARS-CoV-2 RNA clinical samples, either respiratory and nonrespiratory (ie, saliva, serum, urine, vomit, rectal, ocular, cutaneous, and cervico-vaginal swabs), longitudinally collected from both patients throughout the hospitalization. ...
Oxford University Press
Annalisa Mondi, Patrizia Lorenzini, Concetta Castilletti, Roberta Gagliardini, Eleonora Lalle, Angela Corpolongo, Maria Beatrice Valli, Fabrizio Taglietti, Stefania Cicalini, Laura Loiacono, Francesco Di Gennaro, Gianpiero D’Offizi, Fabrizio Palmieri, Emanuele Nicastri, Chiara Agrati, Nicola Petrosillo, Giuseppe Ippolito, Francesco Vaia, Enrico Girardi, Maria Rosaria Capobianchi, Andrea Antinori, Sara Zito, Maria Alessandra Abbonizio, Amina Abdeddaim, Elisabetta Agostini, Chiara Agrati, Fabrizio Albarello, Gioia Amadei, Alessandra Amendola, Andrea Antinori, Maria Assunta Antonica, Mario Antonini, Tommaso Ascoli Bartoli, Francesco Baldini, Maria Raffaella Barbaro, Barbara Bartolini, Rita Bellagamba, Martina Benigni, Nazario Bevilacqua, Gianluigi Biava, Michele Bibas, Licia Bordi, Veronica Bordoni, Evangelo Boumis, Marta Branca, Rosanna Buonomo, Donatella Busso, Marta Camici, Paolo Campioni, Flaminia Canichella, Maria Rosaria Capobianchi, Alessandro Capone, Cinzia Caporale, Emanuela Caraffa, Ilaria Caravella, Fabrizio Carletti, Concetta Castilletti, Adriana Cataldo, Stefano Cerilli, Carlotta Cerva, Roberta Chiappini, Pierangelo Chinello, Maria Assunta Cianfarani, Carmine Ciaralli, Claudia Cimaglia, Nicola Cinicola, Veronica Ciotti, Stefania Cicalini, Francesca Colavita, Angela Corpolongo, Massimo Cristofaro, Salvatore Curiale, Alessandra D’Abramo, Cristina Dantimi, Alessia De Angelis, Giada De Angelis, Maria Grazia De Palo, Federico De Zottis, Virginia Di Bari, Rachele Di Lorenzo, Federica Di Stefano, Gianpiero D’Offizi, Davide Roberto Donno, Francesca Evangelista, Francesca Faraglia, Anna Farina, Federica Ferraro, Lorena Fiorentini, Andrea Frustaci, Matteo Fusetti, Vincenzo Galati, Roberta Gagliardini, Paola Gallì, Gabriele Garotto, Ilaria Gaviano, Saba Gebremeskel Teklè, Maria Letizia Giancola, Filippo Giansante, Emanuela Giombini, Guido Granata, Maria Cristina Greci, Elisabetta Grilli, Susanna Grisetti, Gina Gualano, Fabio Iacomi, Marta Iaconi, G. Iannicelli, Carlo Inversi, Giuseppe Ippolito, Eleonora Lalle, Maria Lamanna, Simone Lanini, Daniele Lapa, Luciana Lepore, Raffaella Libertone, Raffaella Lionetti, Giuseppina Liuzzi, Laura Loiacono, Andrea Lucia, Franco Lufrani, Manuela Macchione, Gaetano Maffongelli, Alessandra Marani, Luisa Marchioni, Andrea Mariano, Maria Cristina Marini, Micaela Maritti, Annelisa Mastrobattista, Ilaria Mastrorosa, Giulia Matusali, Valentina Mazzotta, Paola Mencarini, Silvia Meschi, Francesco Messina, Sibiana Micarelli, Giulia Mogavero, Annalisa Mondi, Marzia Montalbano, Chiara Montaldo, Silvia Mosti, Silvia Murachelli, Maria Musso, Michela Nardi, Assunta Navarra, Emanuele Nicastri, Martina Nocioni, Pasquale Noto, Roberto Noto, Alessandra Oliva, Ilaria Onnis, Sandrine Ottou, Claudia Palazzolo, Emanuele Pallini, Fabrizio Palmieri, Giulio Palombi, Carlo Pareo, Virgilio Passeri, Federico Pelliccioni, Giovanna Penna, Antonella Petrecchia, Ada Petrone, Nicola Petrosillo, Elisa Pianura, Carmela Pinnetti, Maria Pisciotta, Pierluca Piselli, Silvia Pittalis, Agostina Pontarelli, Costanza Proietti, Vincenzo Puro, Paolo Migliorisi Ramazzini, Alessia Rianda, Gabriele Rinonapoli, Silvia Rosati, Dorotea Rubino, Martina Rueca, Alberto Ruggeri, Alessandra Sacchi, Alessandro Sampaolesi, Francesco Sanasi, Carmen Santagata, Alessandra Scarabello, Silvana Scarcia, Vincenzo Schininà, Paola Scognamiglio, Laura Scorzolini, Giulia Valeria Stazi, Giacomo Strano, Fabrizio Taglietti, Chiara Taibi, Giorgia Taloni, Nardi Tetaj, Roberto Tonnarini, Simone Topino, Martina Tozzi, Francesco Vaia, Francesco Vairo, Maria Beatrice Valli, Alessandra Vergori, Laura Vincenzi, Ubaldo Visco‐Comandini, Serena Vita, Pietro Vittozzi, Mauro Zaccarelli, Antonella Zanetti, Sara Zito, Maria Alessandra Abbonizio, Amina Abdeddaim, Elisabetta Agostini, Chiara Agrati, Fabrizio Albarello, Gioia Amadei, Alessandra Amendola, Andrea Antinori, Maria Assunta Antonica, Mario Antonini, Tommaso Ascoli Bartoli, Francesco Baldini, Maria Raffaella Barbaro, Barbara Bartolini, Rita Bellagamba, Martina Benigni, Nazario Bevilacqua, Gianluigi Biava, Michele Bibas, Licia Bordi, Veronica Bordoni, Evangelo Boumis, Marta Branca, Rosanna Buonomo, Donatella Busso, Marta Camici, Paolo Campioni, Flaminia Canichella, Maria Rosaria Capobianchi, Alessandro Capone, Cinzia Caporale, Emanuela Caraffa, Ilaria Caravella, Fabrizio Carletti, Concetta Castilletti, Adriana Cataldo, Stefano Cerilli, Carlotta Cerva, Roberta Chiappini, Pierangelo Chinello, Maria Assunta Cianfarani, Carmine Ciaralli, Claudia Cimaglia, Nicola Cinicola, Veronica Ciotti, Stefania Cicalini, Francesca Colavita, Angela Corpolongo, Massimo Cristofaro, Salvatore Curiale, Alessandra D’Abramo, Cristina Dantimi, Alessia De Angelis, Giada De Angelis, Maria Grazia De Palo, Federico De Zottis, Virginia Di Bari, Rachele Di Lorenzo, Federica Di Stefano, Gianpiero D’Offizi, Davide Roberto Donno, Francesca Evangelista, Francesca Faraglia, Anna Farina, Federica Ferraro, Lorena Fiorentini, Andrea Frustaci, Matteo Fusetti, Vincenzo Galati, Roberta Gagliardini, Paola Gallì, Gabriele Garotto, Ilaria Gaviano, Saba Gebremeskel Teklè, Maria Letizia Giancola, Filippo Giansante, Emanuela Giombini, Guido Granata, Maria Cristina Greci, Elisabetta Grilli, Susanna Grisetti, Gina Gualano, Fabio Iacomi, Marta Iaconi, G. Iannicelli, Carlo Inversi, Giuseppe Ippolito, Eleonora Lalle, Maria Lamanna, Simone Lanini,
BackgroundLimited data are available about the predictors and outcomes associated with prolonged SARS-CoV-2 RNA shedding (VS).MethodsA retrospective study including COVID-19 patients admitted to an Italian hospital between March 1 and July 1, 2020. Predictors of viral clearance (VC) and prolonged VS from the upper respiratory tract were assessed by Poisson regression and logistic regression analyses. The causal relation between VS and clinical outcomes was evaluated through an inverse probability ...
Elsevier BV
Emanuele Nicastri, Concetta Castilletti, Mirella Biava, Francesco Maria Fusco, Nicola Petrosillo, Vincenzo Puro, F. Lauria, Maria Rosaria Capobianchi, Antonino Di, Giuseppe Ippolito,
The unprecedented epidemic of Ebola virus disease (EVD) in West Africa highlighted the need for stronger systems for disease surveillance, response, and prevention worldwide. Tackling an epidemic event today requires a broader view, not only limited to medical management of the patients, but which also includes heroic efforts by clinicians and public health personnel. Since its foundation in 1936, INMI has been devoted to the prevention, diagnosis and care for infectious diseases. In 2009, INMI became ...
Tópico(s): Global Security and Public Health
2016 - Springer Nature | Advances in experimental medicine and biology