Claudia Capparelli, Carmela Guido, Diana Whitaker‐Menezes, Gloria Bonuccelli, Renee M. Balliet, Timothy G. Pestell, Allison Goldberg, Richard G. Pestell, Anthony Howell, Sharon Sneddon, Ruth Birbe, Aristotelis Tsirigos, Ubaldo Martinez‐Outschoorn, Federica Sotgia, Michael P. Lisanti,
Senescent fibroblasts are known to promote tumor growth. However, the exact mechanism remains largely unknown. An important clue comes from recent studies linking autophagy with the onset of senescence. Thus, autophagy and senescence may be part of the same physiological process, known as the autophagy-senescence transition (AST). To test this hypothesis, human fibroblasts immortalized with telomerase (hTERT-BJ1) were stably transfected with autophagy genes (BNIP3, CTSB or ATG16L1). Their overexpression ...
Tópico(s): Telomeres, Telomerase, and Senescence
2012 - Taylor & Francis | Cell Cycle
... 2021).https://doi.org/10.1111/oik.08310Cyro Menezes da Glória, Alexandro Marques Tozetti Bird visits and resource use ...
Tópico(s): Insect and Arachnid Ecology and Behavior
1979 - University of Chicago Press | The American Naturalist
Casey Trimmer, Diana Whitaker‐Menezes, Gloria Bonuccelli, Janet N. Milliman, Kristin M. Daumer, Andrew E. Aplin, Richard G. Pestell, Federica Sotgia, Michael P. Lisanti, Franco Capozza,
Abstract Caveolin-1 (CAV1) is the main structural component of caveolae, which are plasma membrane invaginations that participate in vesicular trafficking and signal transduction events. Although evidence describing the function of CAV1 in several cancer types has recently accumulated, its role in melanoma tumor formation and progression remains poorly explored. Here, by using B16F10 melanoma cells as an experimental system, we directly explore the function of CAV1 in melanoma tumor growth and metastasis. ...
Tópico(s): RNA Research and Splicing
2010 - American Association for Cancer Research | Cancer Research
Ana Catarina Menezes, M. Glória Gomes, Inês Flores‐Colen,
The use of in-situ diagnostic techniques can lead to a more accurate evaluation of the performance level of façade claddings. The paper aims to evaluate the advantages of using visual inspection and selected in-situ techniques (infrared thermography, Karsten tubes and moisture meter) for the evaluation of the physical performance of renders and their state of deterioration. The main objective of the study is to propose a methodology for in-situ inspections with a low degree of intrusion for the evaluation ...
Tópico(s): Building Energy and Comfort Optimization
2014 - Elsevier BV | Construction and Building Materials
Produção Nacional
Revisado por pares
Kátia Daniela Ribeiro, Stélio Maia Menezes, Maria da Glória Bastos de Freitas Mesquita, F. de M. T. Sampaio,
A distribuição de poros dos solos condiciona seu comportamento físico-hídrico. Assim, influencia os processos dinâmicos do ar e da solução do solo, bem como a potencialidade agrícola dos mesmos. Desta forma, com o presente trabalho, objetivou-se avaliar a influência da distribuição de poros sobre as propriedades físicas de seis classes de solos, sob vegetação natural, localizados na região de Lavras (MG). Coletaram-se amostras deformadas e indeformadas da camada superficial (0-20 cm) para a caracterização ...
Tópico(s): Growth and nutrition in plants
2007 - UNIVERSIDADE FEDERAL DE LAVRAS | Ciência e Agrotecnologia
Produção Nacional
Revisado por pares
Karla Fabiana Goessler, Véronique Cornelissen, Edilamar Menezes de Oliveira, Glória de Fátima Alves da Mota, Marcos Doederlein Polito,
Polymorphisms of the angiotensin converting enzyme (ACE) gene can interfere with exercise-induced acute blood pressure (BP) reduction. This cross-over study investigated the acute effect of a single walk on BP and tested whether polymorphisms of the ACE gene might explain the variation in BP responses.Thirty-four healthy medicated individuals were randomized to one control and one walking session at 60-75% of heart rate reserve. Subjects left the laboratory wearing an ambulatory BP monitor until waking ...
Tópico(s): Cardiovascular Effects of Exercise
2015 - SAGE Publishing | Journal of the Renin-Angiotensin-Aldosterone System
Produção Nacional
Revisado por pares
Marina C. Oliveira, Zélia Menezes‐Garcia, Raquel Duque do Nascimento Arifa, Talles Prosperi de Paula, João Marcus Oliveira Andrade, Sérgio Henrique Sousa Santos, Gustavo Batista Menezes, Danielle da Glória de Souza, Mauro Martins Teixeira, Adaliene Versiani Matos Ferreira,
Hepatic diseases are comorbidities caused by obesity and are influenced by diet composition. The aim of this study was to evaluate the kinetics of metabolic and inflammatory liver dysfunction induced by a high-refined carbohydrate-containing (HC) diet and to determine how platelet-activating factor (PAF) modulates the liver lipid content of mice. BALB/c mice were fed a chow or HC diet for the following experimental periods: 1 and 3 days, 1, 2, 4, 6, 8, 10 and 12 weeks. Wild-type (WT) and PAF receptor- ...
Tópico(s): Cholesterol and Lipid Metabolism
2015 - Elsevier BV | The Journal of Nutritional Biochemistry
Produção Nacional
Revisado por pares
Fábio Gomes de Matos e Souza, Maria da Glória Carneiro Menezes,
Resumo: O objetivo deste estudo é avaliar o nível de estresse em estudantes de Medicina da Universidade Federal do Ceará. A amostra constituiu-se de 562 estududantes distribuídos nos semestres de I a IX. O instrumento utilizado foi o General Health Questionnaire (GHQ), no qual o estresse foi definido com escore maior que 3, além de uma ficha com dados pessoais. A prevalência de distúrbios psicológicos em estudantes de Medicina foi de 35,4% (n = 199). As mulheres apresentaram um nível de estresse maior ...
Tópico(s): Optimism, Hope, and Well-being
2005 - Associção Brasileira de Educação Médica | Revista Brasileira de Educação Médica
Produção Nacional
Revisado por pares
Dariana Pimentel Gomes Hübner, Patrícia de Brum Vieira, Amanda Piccoli Frasson, Camila Braz Menezes, Franciane Rios Senger, Gloria Narjara Santos da Silva, Simone Cristina Baggio Gnoatto, Tiana Tasca,
Caused by Trichomonas vaginalis, trichomoniasis is the most common non-viral STD worldwide. Currently, metronidazole and tinidazole are the only drugs approved for treatment of the condition. However, problems such as metronidazole-resistant T. vaginalis isolates and allergic reactions have been reported. Based on data previously published by our group, structural changes in betulinic acid (1) were performed, generating three new compounds that were tested for in vitro anti-T.vaginalis activity in ...
Tópico(s): Phytochemical compounds biological activities
2016 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Débora Fernandes Rodrigues, Milene Cristina do Carmo Henriques, Marina C. Oliveira, Zélia Menezes‐Garcia, Pedro Elias Marques, Danielle da Glória de Souza, Gustavo Batista Menezes, Mauro Martins Teixeira, Adaliene Versiani Matos Ferreira,
The postprandial state is a period of metabolic fluxes, biosynthesis and oxidative metabolism. A considerable amount is known about the inflammatory response to the chronic consumption of fructose, but little is known about its effects in the postprandial state. The aim of the present study was to investigate the inflammatory effects of a single meal containing fructose on healthy mice. Male BALB/c and LysM-eGFP mice at 12–14 weeks were divided into three groups: fasted, control (mice fed with a ...
Tópico(s): Liver Disease Diagnosis and Treatment
2013 - Elsevier BV | The Journal of Nutritional Biochemistry
Ubaldo Martinez‐Outschoorn, Diana Whitaker‐Menezes, Stephanos Pavlides, Barbara Chiavarina, Gloria Bonuccelli, Casey Trimmer, Aristotelis Tsirigos, G Migneco, Agnieszka K. Witkiewicz, Renee M. Balliet, Isabelle Le Mercier, Chengwang Wang, Neal Flomenberg, Anthony Howell, Lin Zhao, J. Jaime, Richard G. Pestell, Federica Sotgia, Michael P. Lisanti,
The role of autophagy in tumorigenesis is controversial. Both autophagy inhibitors (chloroquine) and autophagy promoters (rapamycin) block tumorigenesis by unknown mechanism(s). This is called the “Autophagy Paradox”. We have recently reported a simple solution to this paradox. We demonstrated that epithelial cancer cells use oxidative stress to induce autophagy in the tumor microenvironment. As a consequence, the autophagic tumor stroma generates recycled nutrients that can then be used as chemical ...
Tópico(s): Epigenetics and DNA Methylation
2010 - Taylor & Francis | Cell Cycle
Produção Nacional
Revisado por pares
Glória Menezes, Lígia De Lima-Cavalcanti, Angela Maria De Morais-Oliveira, Rogério De Melo Costa-Pinto, Vânia Olivetti Steffen-Abdallah,
Evaluation of procedures during household milking and transport of human milk associated with their quality control.48 donors registered in the Human Milk Bank of the Clinics Hospital of the Federal University at Uberlândia. Observations were made during home visits. A checklist was elaborated according to the technical standards for human milk banks, been associated with physical-chemical, and microbiological controls. The chi-square test, logistic regression and Spearman test (p< 0.05) were used ...
Tópico(s): Breastfeeding Practices and Influences
2014 - Instituto Nacional de Salud Pública | Salud Pública de México
Produção Nacional
Revisado por pares
Luana Pereira Antunes Dourado, Maria de Lourdes Meirelles Noviello, Débora Moreira Alvarenga, Zélia Menezes, Denise Perez, Nathália Vieira Batista, Gustavo Batista Menezes, Adaliene Versiani Matos Ferreira, Danielle da Glória de Souza, Denise Carmona Cara,
To investigate the consequences of food allergy in adipose tissue and metabolism, we used a murine model in which mice have been sensitized subcutaneously with ovalbumin and further received antigen-containing diet. Allergic mice presented a significant weight loss 7 days after oral challenge with a concomitant decrease in epididymal adipose tissue mass. This decrease was associated with increased lipolysis and local inflammation. In adipose tissue of allergic mice there were increased leukocyte ...
Tópico(s): Regulation of Appetite and Obesity
2011 - Elsevier BV | Cellular Immunology
Produção Nacional
Revisado por pares
Camila Menezes Costa Castelo Branco, Gloria Cabral, Alix Maria Gregory Sawaya Castro, Ana Cristina Fernandes Maria Ferreira, Carlos Felipe Bonacina, Adrian Lussi, Maria Teresa Botti Rodrigues Santos, Michèle Baffi Diniz,
Abstract Aims To compare the dental caries prevalence using the International Caries Detection and Assessment System (ICDAS) and the caries risk by Caries Management by Risk Assessment (CAMBRA) in individuals with cerebral palsy (CP) and normoactives (NAs). Methods and results Sixty children and adolescents aged 6–12 years (30 CP/30 NA) were clinically evaluated by one calibrated examiner using two‐digit ICDAS criteria and converted into components of dmf/DMF indices: d2mf2/D2MF2 (enamel and dentin lesions) ...
Tópico(s): Cerebral Palsy and Movement Disorders
2021 - Wiley | Special Care in Dentistry
Produção Nacional
Revisado por pares
Thiago Mafra Batista, Heron Oliveira Hilário, Gabriel Antônio Mendes de Brito, Rennan Garcias Moreira, Carolina Furtado, Graciéle Cunha Alves de Menezes, Carlos A. Rosa, Luiz Henrique Rosa, Glória Regina Franco,
The snow-covered surfaces of Antarctica comprise an extreme environment that favors the development of life forms with adaptations to adverse low-temperature habitats. The ability to survive and such temperatures might involve the production of antifreeze proteins and ice-binding proteins that attenuate the effects of intense cold temperatures. He, we sequenced and reconstructed the nuclear and mitochondrial genomes of the endemic Antarctic fungus Antarctomyces pellizariae UFMGCB 12416. We then ...
Tópico(s): Microbial Community Ecology and Physiology
2020 - Elsevier BV | Genomics
Produção Nacional
Revisado por pares
Cyro Menezes da Glória, Alexandro Marques Tozetti,
ABSTRACT We evaluated avian use of a palm grove of Butia odorata (Barb. Rodr.) Noblick in the Brazilian Pampa. We recorded bird species richness, frequency of visits, and feeding behavior in palms trees with different flower and fruit availability. From January 2018 to February 2019, we observed 1,094 bird visits in 347 palm trees and identified 53 species. The most frequent visitors were Sicalis flaveola (Linnaeus, 1766), Myiopsitta monachus (Boddaert, 1783) and Zonotrichia capensis (Statius Muller, ...
Tópico(s): Botany, Ecology, and Taxonomy Studies
2021 - Fundación Zoobotánica de Rio Grande do Sul | Iheringia Série Zoologia
Gloria Bonuccelli, Diana Whitaker‐Menezes, Remedios Castelló-Cros, Stephanos Pavlides, Richard G. Pestell, Alessandro Fatatis, Agnieszka K. Witkiewicz, Matthew G. Vander Heiden, G Migneco, Barbara Chiavarina, Philippe G. Frank, Franco Capozza, Neal Flomenberg, Ubaldo Martinez‐Outschoorn, Federica Sotgia, Michael P. Lisanti,
AbstractWe and others have previously identified a loss of stromal caveolin-1 (Cav-1) in cancer-associated fibroblasts (CAFs) as a powerful single independent predictor of breast cancer patient tumor recurrence, metastasis, tamoxifen-resistance, and poor clinical outcome. However, it remains unknown how loss of stromal Cav-1 mediates these effects clinically. To mechanistically address this issue, we have now generated a novel human tumor xenograft model. In this two-component system, nude mice are ...
Tópico(s): Cancer, Hypoxia, and Metabolism
2010 - Taylor & Francis | Cell Cycle
Gloria Portocarrero Huang, Roseline Menezes, Richard Vincent, Willis B. Hammond, Louis Rizio, George Collins, Treena Livingston Arinzeh,
Articular cartilage has a limited capacity to heal after damage from injury or degenerative disease. Tissue engineering constructs that more closely mimic the native cartilage microenvironment can be utilized to promote repair. Glycosaminoglycans (GAGs), a major component of the cartilage extracellular matrix, have the ability to sequester growth factors due to their level and spatial distribution of sulfate groups. This study evaluated the use of a GAG mimetic, cellulose sulfate, as a scaffolding ...
Tópico(s): Silk-based biomaterials and applications
2017 - Mary Ann Liebert, Inc. | Tissue Engineering Part A
Produção Nacional
Revisado por pares
Luís Fernando Tavares de Menezes, Francisco I. Pugnaire, Gloria Matallana, Felipe Cito Nettesheim, Daniel Costa de Carvalho, Eduardo Arcoverde de Mattos,
Germination rate and establishment success of plants in harsh environments depend on the ability of seeds to withstand unfavorable environmental conditions and avoid predators. Brazilian coastal plains, known as restinga, are subject to environmental factors that seriously limit plant establishment and survival (e.g. salinity, desiccation, oligotrophy, flooding, high temperature and radiation levels). We tested, both in field and laboratory experiments, conditions for germination and establishment ...
Tópico(s): Seed Germination and Physiology
2017 - Sociedade Botânica do Brasil | Acta Botanica Brasilica
Produção Nacional
Fabrício Assis Leal, Cátia Menezes de Souza, Glória da Silva Almeida Leal, Éder Pereira Miguel,
O objetivo deste trabalho foi avaliar a vegetação do Parque Nacional das Emas antes e após a ocorrência de fogo, por meio do NDVI. Para a obtenção do NDVI foram utilizadas imagens do satélite ResourceSat-1, em julho/2010 (antes) e setembro/2010 (após). Foram aleatorizados pontos amostrais nas classes mais representativas de vegetação do PARNA, sendo: 60 pontos na classe Campo, 45 pontos na classe Cerrado, 35 pontos na classe Várzea e 35 pontos na classe Mata. Os valores encontrados de NDVI nos pontos ...
Tópico(s): Environmental and biological studies
2019 - UNIVERSIDADE FEDERAL DE MATO GROSSO | Nativa
Produção Nacional
Revisado por pares
Nanuza Luíza de Menezes, Paula Elbl, Graziela Cury, Beatriz Appezzato‐da‐Glória, K Sasaki, Cristiane G. da Silva, Gisele R. Costa, Vera G.A. Lima,
Background: It had long been thought that a lateral meristem, the so-called primary thickening meristem (PTM) was responsible for stem thickening in monocotyledons. Recent work has shown that primary thickening in the stems of monocotyledons is due to the meristematic activity of both the endodermis and the pericycle. Aims: The aim of this work is to answer a set of questions about the developmental anatomy of monocotyledonous plants: (1) Do the stem apices of monocots have a special meristematic ...
Tópico(s): Plant Reproductive Biology
2012 - Taylor & Francis | Plant Ecology & Diversity
Elena I. Stepchenkova, Elena Tarakhovskaya, Kathryn M. Spitler, Christin Frahm, Miriam R. Menezes, Peter D. Simone, Carol Kolar, Luis A. Marky, Gloria E. O. Borgstahl, Youri I. Pavlov,
Sanitization of the cellular nucleotide pools from mutagenic base analogues is necessary for the accuracy of transcription and replication of genetic material and plays a substantial role in cancer prevention. The undesirable mutagenic, recombinogenic, and toxic incorporation of purine base analogues [i.e., ITP, dITP, XTP, dXTP, or 6-hydroxylaminopurine (HAP) deoxynucleoside triphosphate] into nucleic acids is prevented by inosine triphosphate pyrophosphatase (ITPA). The ITPA gene is a highly conserved, ...
Tópico(s): Adenosine and Purinergic Signaling
2009 - Elsevier BV | Journal of Molecular Biology
Produção Nacional
Guilherme B. Alves, Edilamar Menezes de Oliveira, Cléber R. Alves, Heron Rhydan Saad Rached, Glória F.A. Mota, Alexandre C. Pereira, Maria Urbana Pinto Brandão Rondon, Nara Yumi Hashimoto, Luciene Ferreira Azevedo, José Eduardo Krieger, Carlos Eduardo Negrão,
The allele threonine (T) of the angiotensinogen has been associated with ventricular hypertrophy in hypertensive patients and soccer players. However, the long-term effect of physical exercise in healthy athletes carrying the T allele remains unknown. We investigated the influence of methionine (M) or T allele of the angiotensinogen and D or I allele of the angiotensin-converting enzyme on left-ventricular mass index (LVMI) and maximal aerobic capacity in young healthy individuals after long-term physical ...
Tópico(s): Muscle metabolism and nutrition
2009 - SAGE Publishing | European Journal of Cardiovascular Prevention & Rehabilitation
Produção Nacional
Revisado por pares
Marcelo V. Negrão, Cléber R. Alves, Guilherme B. Alves, Alexandre C. Pereira, Rodrigo Gonçalves Dias, Mateus Camaroti Laterza, Glória F.A. Mota, Edilamar Menezes de Oliveira, Vinícius Bassaneze, José Eduardo Krieger, Carlos Eduardo Negrão, Maria Urbana Pinto Brandão Rondon,
Allele T at promoter region of the eNOS gene has been associated with an increase in coronary disease mortality, suggesting that this allele increases susceptibility for endothelial dysfunction. In contrast, exercise training improves endothelial function. Thus, we hypothesized that: 1) Muscle vasodilatation during exercise is attenuated in individuals homozygous for allele T, and 2) Exercise training improves muscle vasodilatation in response to exercise for TT genotype individuals. From 133 preselected ...
Tópico(s): Cardiovascular Effects of Exercise
2010 - American Physical Society | Physiological Genomics
Produção Nacional
Revisado por pares
Rayany Magali da Rocha Santana, Daniella Carla Napoleão, Joan Manuel Rodríguez-Díaz, Rayssa Kelen de Mendonça Gomes, Marina Gomes Silva, Victor Marcelo Estolano de Lima, Antônio Acácio de Melo Neto, Glória Maria Vinhas, Marta Maria Menezes Bezerra Duarte,
Fenton-type advanced oxidative processes (AOP) have been employed to treat textile dyes in aqueous solution and industrial effluent. The work focused on assisting the limitations still presented by the Fenton process regarding the use of suspended iron catalysts. Soon, a nanocomposite of bacterial cellulose (BC) and magnetite (Fe3O4) was developed. It has proven to be superior to those available in the literature, exhibiting purely catalytic properties and high reusability. Its successful production ...
Tópico(s): Nanoparticles: synthesis and applications
2023 - Elsevier BV | Chemosphere
Produção Nacional
Revisado por pares
Rayany Magali da Rocha Santana, Daniella Carla Napoleão, Joan Manuel Rodríguez-Díaz, Rayssa Kelen de Mendonça Gomes, Marina Gomes Silva, R. Peña‐Garcia, Glória Maria Vinhas, Marta Maria Menezes Bezerra Duarte,
The development of an original catalytic composite of bacterial cellulose (BC) and pyrite (FeS2) for environmental application was the objective of this study. Nanoparticles of the FeS2 were synthesized from the hydrothermal method and immobilized on the BC structure using ex situ methodology. In the BC, the FTIR and XRD analyzes showed the absorption band associated with the Fe-S bond and crystalline peaks attributed to the pyrite. Thus, the immobilization of the iron particles on the biopolymer ...
Tópico(s): Nanoparticles: synthesis and applications
2023 - Elsevier BV | Chemosphere
Produção Nacional
Revisado por pares
Adriana Cláudia Lapria Faria, Ubiratan Menezes Benassi, Renata Cristina Silveira Rodrigues, Ricardo Faria Ribeiro, Maria da Glória Chiarello de Mattos,
This study evaluated the surface hardness and wear resistance of indirect composites (Artglass and Solidex) and the existence of a correlation between these properties. Twenty-four specimens (12 per material) were fabricated using a polytetrafluoroethylene matrix (5.0 mm in diameter; 7.0 mm high) following an incremental technique. Polymerization was done with a xenon stroboscopic light curing unit. After polishing, the specimens were stored in water at 37 degrees C during either 1 day (n=6 per material) ...
Tópico(s): Infrastructure Maintenance and Monitoring
2007 - Fundação Odontológica de Ribeirão Preto | Brazilian Dental Journal
Produção Nacional
Revisado por pares
Glória Maria Menezes Caldas, Renata Cabrera de Oliveira, Dauri José Tessmann, Miguel Machinski,
A podridão ácida é uma patologia das videiras, de alta freqüência nos períodos quentes e chuvosos, em conseqüência do desenvolvimento de fungos e bactérias em seus frutos. Um dos gêneros de fungos responsáveis por esta doença é o Penicillium spp., que poderá levar à produção de micotoxinas, como a patulina. Neste trabalho, foi realizada uma investigação sobre a podridão ácida e a ocorrência de patulina em uvas Itália (Vitis vinifera L. cv. Rubi) cultivadas no município de Marialva, Brasil. Foram ...
Tópico(s): Plant Pathogens and Fungal Diseases
2007 - UNIVERSIDADE FEDERAL DE SANTA MARIA | Ciência Rural
Produção Nacional
Revisado por pares
Luiz Marcelo Aiello Viarengo, João Potério-Filho, Glória Maria Braga Potério, Fábio Hüsemann Menezes, Guilherme Vieira Meirelles,
Conventional saphenous vein stripping is difficult to be indicated for the treatment of varicose veins in patients classified as CEAP C4, C5, or C6.This study was developed to evaluate treatment results for varicose veins with active ulcers using endovenous laser (EVL), compared to a group undergoing clinical treatment, during 1 year.Fifty-two patients presenting with varicose veins with active ulcers for more than 1 year were divided for treatment into two randomized groups: Group 1, clinical treatment, ...
Tópico(s): Dermatologic Treatments and Research
2007 - Lippincott Williams & Wilkins | Dermatologic Surgery
Produção Nacional
Revisado por pares
Valdecir Galindo Filho, Daniella Cunha Brandão, Rita de Cássia S Ferreira, Maria José C Menezes, Paulo Almeida-Filho, Verônica Franco Parreira, Tayse N Silva, Maria da Glória Rodrigues‐Machado, Elizabeth Dean, Arméle Dornelas de Andrade,
BACKGROUND: Despite the clinical improvements attributed to noninvasive ventilation (NIV) during asthma crises, and the well established effects of nebulization, there are few studies on the effects of these interventions together. We hypothesized that nebulization coupled to NIV should raise radio-aerosol pulmonary deposition in asthmatics. The aims of this study were to assess the effects of coupling β-agonist nebulization and NIV during asthma exacerbations on radio-aerosol pulmonary deposition, using scintigraphy ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2013 - American Association for Respiratory Care | Respiratory Care