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Artigo Acesso aberto Revisado por pares

Tonali Blanco Ayala, Daniela Ramírez Ortega, Paulina Ovalle Rodríguez, Benjamín Pineda, Gonzalo Pérez de la Cruz, Dinora F. González‐Esquivel, Robert Schwarcz, Korrapati V. Sathyasaikumar, Anabel Jiménez‐Anguiano, Verónica Pérez de la Cruz,

The tryptophan (Trp) metabolite kynurenic acid (KYNA) is an α7-nicotinic and N-methyl-d-aspartate receptor antagonist. Elevated brain KYNA levels are commonly seen in psychiatric disorders and neurodegenerative diseases and may be related to cognitive impairments. Recently, we showed that N-acetylcysteine (NAC) inhibits kynurenine aminotransferase II (KAT II), KYNA’s key biosynthetic enzyme, and reduces KYNA neosynthesis in rats in vivo. In this study, we examined if repeated systemic administration ...

Tópico(s): Gut microbiota and health

2021 - Multidisciplinary Digital Publishing Institute | Antioxidants

Artigo Revisado por pares

Eduardo Pineda, Gonzalo Halffter,

We evaluate the alpha (within patch species richness), beta (spatial turnover among patches) and gamma (landscape) diversity of frogs in a tropical montane cloud forest (TMCF) in central Veracruz, Mexico in order to assess (1) the influence of forest fragmentation on frog assemblages, (2) the importance to diversity of the various elements of the landscape matrix, including the shaded coffee plantations and cattle pastures that surround TMCF and (3) to identify the frog guilds most affected by habitat ...

Tópico(s): Ecology and Vegetation Dynamics Studies

2003 - Elsevier BV | Biological Conservation

Artigo Acesso aberto Revisado por pares

Carl Llor, Josep M. Cots, Beatriz González López‐Valcárcel, Juan de Dios Alcántara, Guillermo García, Javier Arranz Izquierdo, María José Monedero, Jesús Almeda, V. Pineda, Gonzalo Garcia Guerra, Manuel Arias, Sara B. Hernández, José Luis Paredes, M. Cid, Carolina Pérez-García,

To evaluate the effect of two interventions on reducing antibiotic prescription in pharyngitis. A prospective, non-randomized, before–after controlled study was carried out in primary care centres throughout Spain. General practitioners (GPs) registered all cases of pharyngitis during a 3 week period before and after two types of intervention in 2008 and 2009, respectively. Full intervention consisted of discussion sessions of the results of the first registry, courses for GPs, guidelines, patient ...

Tópico(s): Antibiotic Use and Resistance

2010 - Oxford University Press | Journal of Antimicrobial Chemotherapy

Artigo Acesso aberto Revisado por pares

Andrea Cecilia Bruballa, Carolina Maiumi Shiromizu, Alan Mauro Bernal, Gonzalo Ezequiel Pineda, Florencia Sabbione, Analía Trevani, Leticia V. Bentancor, María Victoria Ramos, Romina Jimena Fernández-Brando, Manuel J. Muñoz, Marina S. Palermo,

Enterohemorrhagic Escherichia coli (EHEC) strains are food-borne pathogens that can cause different clinical conditions. Shiga toxin 2a and/or 2c (Stx2)-producing E. coli O157:H7 is the serotype most frequently associated with severe human disease. In this work we analyzed the hypothesis that host cells participate in Stx2 production, cell damage, and inflammation during EHEC infection. With this aim, macrophage-differentiated THP-1 cells and the intestinal epithelial cell line HCT-8 were incubated ...

Tópico(s): Vibrio bacteria research studies

2020 - Multidisciplinary Digital Publishing Institute | Toxins

Artigo Acesso aberto Revisado por pares

Miguel Á. Chávez‐Fumagalli, Pallavi Shrivastava, Jorge Alberto Aguilar-Pineda, Rita Nieto-Montesinos, Gonzalo Dávila-Del-Carpio, A. Peralta, Claudia Caracela-Zeballos, Guillermo Valdez-Lazo, Victor Fernandez-Macedo, Alejandro Pino‐Figueroa, Karin J. Vera-López, Christian L. Lino Cardenas,

Background: The present systematic review and meta-analysis of diagnostic test accuracy summarizes the last three decades in advances on diagnosis of Alzheimer’s disease (AD) in developed and developing countries. Objective: To determine the accuracy of biomarkers in diagnostic tools in AD, for example, cerebrospinal fluid, positron emission tomography (PET), and magnetic resonance imaging (MRI), etc. Methods: The authors searched PubMed for published studies from 1990 to April 2020 on AD diagnostic ...

Tópico(s): Health, Environment, Cognitive Aging

2020 - IOS Press | Journal of Alzheimer s Disease Reports

Artigo Acesso aberto Revisado por pares

Alan Mauro Bernal, Romina Jimena Fernández-Brando, Andrea Cecilia Bruballa, Gabriela A. Fiorentino, Gonzalo Ezequiel Pineda, Elsa Zotta, Mónica Vermeulen, María Victoria Carballo Calero Ramos, Martı́n Rumbo, Marina S. Palermo,

Enterohemorrhagic Escherichia coli (EHEC) infections can result in a wide range of clinical presentations despite that EHEC strains belong to the O157:H7 serotype, one of the most pathogenic forms. Although pathogen virulence influences disease outcome, we emphasize the concept of host-pathogen interactions, which involve resistance or tolerance mechanisms in the host that determine total host fitness and bacterial virulence. Taking advantage of the genetic differences between mouse strains, we analyzed ...

Tópico(s): Immune Cell Function and Interaction

2021 - American Society for Microbiology | Infection and Immunity

Artigo Acesso aberto Revisado por pares

Daniela Ramírez Ortega, Perla Eugenia Ugalde Muñiz, Tonali Blanco Ayala, Gustavo Ignacio Vázquez Cervantes, Rafael Lugo Huitrón, Benjamín Pineda, Dinora F. González‐Esquivel, Gonzalo Pérez de la Cruz, José Pedraza-Chaverrı́, Laura Sánchez‐Chapul, Saúl Gómez‐Manzo, Verónica Pérez de la Cruz,

L-kynurenine (L-KYN) is an endogenous metabolite, that has been used as a neuroprotective strategy in experimental models. The protective effects of L-KYN have been attributed mainly to kynurenic acid (KYNA). However, considering that L-KYN is prone to oxidation, this redox property may play a substantial role in its protective effects. The aim of this work was to characterize the potential impact of the redox properties of L-KYN, in both synthetic and biological systems. First, we determined whether ...

Tópico(s): Circadian rhythm and melatonin

2021 - Multidisciplinary Digital Publishing Institute | Antioxidants

Artigo Acesso aberto Revisado por pares

Marlina Olyissa Córdoba-Moreno, María Florencia Todero, Adriana Fontanals, Gonzalo Ezequiel Pineda, Montagna Daniela, Noemí Yokobori, María Victoria Carballo Calero Ramos, Gabriela Barrientos, Jorge E. Toblli, Martı́n A. Isturiz, Bárbara Rearte,

Sepsis constitutes one of the major causes of death in ICUs. In sepsis induced by gram-negative, although lipopolysaccharide (LPS) initially induces an exacerbated secretion of proinflammatory cytokines leading to endotoxic shock and death resembling a septic shock, it is also capable of inducing refractoriness to subsequent challenge with LPS, a state known as endotoxin tolerance, which is considered the initial step of the immunosuppression found in septic patients. As we previously demonstrated ...

Tópico(s): Cytokine Signaling Pathways and Interactions

2018 - Lippincott Williams & Wilkins | Shock

Artigo Acesso aberto Revisado por pares

Miryam Pastor, Rosalía Fernández‐Calle, Bruno Di Geronimo, Marta Vicente‐Rodríguez, José María Zapico, Esther Gramage, Claire Coderch, Carmen Pérez‐García, Amy W. Lasek, Leonor Puchades‐Carrasco, Antonio Pineda‐Lucena, Beatriz de Pascual‐Teresa, Gonzalo Herradón, Ana Ramos,

A new series of blood-brain barrier permeable molecules designed to mimic the activity of Pleiotrophin in the CNS has been designed and synthesized. These compounds exert their action by interacting with the intracellular domain PD1 of the Protein Tyrosine-Phosphatase Receptor Z1 (PTPRZ1), and inhibiting its tyrosine phosphatase activity. The most potent compounds 10a and 12b (IC50 = 0,1 μM) significantly increase the phosphorylation of key tyrosine residues of PTPRZ1 substrates involved in neuronal ...

Tópico(s): Seaweed-derived Bioactive Compounds

2017 - Elsevier BV | European Journal of Medicinal Chemistry

Artigo Acesso aberto Revisado por pares

José Luis Marín‐Muñiz, Irma Zitácuaro-Contreras, Gonzalo Ortega-Pineda, Aarón López-Roldán, Monserrat Vidal-Álvarez, Karina Elizabeth Martínez-Aguilar, Luis Manuel Álvarez-Hernández, Sergio Aurelio Zamora Castro,

The assessment of constructed wetlands (CWs) has gained interest in the last 20 years for wastewater treatment in Latin American regions. However, the effects of culture systems with different ornamental species in CWs for phytoremediation are little known. In this study, some chemical parameters such as total suspended solids (TSS), chemical oxygen demand (COD), phosphate (PO4-P), and ammonium (NH4-N) were analyzed in order to prove the removal of pollutants by phytoremediation in CWs. The environmental ...

Tópico(s): Wastewater Treatment and Reuse

2024 - Multidisciplinary Digital Publishing Institute | Plants

Artigo Revisado por pares

Eduardo Pineda, Claudia E. Moreno, Federico Escobar, Gonzalo Halffter,

Abstract: We compared the species diversity of copronecrophagous beetles (Scarabaeinae) , bats, and frogs in tropical montane cloud forest (original vegetation) and shaded coffee plantations (an agroecosystem common to the region) for a landscape in central Veracruz, Mexico. We sampled in three tropical montane cloud forest fragments and in three coffee plantations with traditional polyculture shade between 1998 and 2001. The three indicator groups responded differently to the transformation of tropical ...

Tópico(s): Amphibian and Reptile Biology

2005 - Wiley | Conservation Biology

Artigo Acesso aberto Revisado por pares

Gonzalo Halffter, Eduardo Pineda, Lucrecia Arellano, Federico Escobar,

We analyzed changes over time in species composition and functional guild structure (temporal beta diversity) for natural assemblages and those modified by humans in a fragmented, tropical mountain landscape. The assemblages belong to cloud forests (the original vegetation type), secondary forests, traditional shaded coffee plantations, commercial shaded coffee plantations, and a cattle pasture. Copronecrophagous beetles, subfamily Scarabaeinae (Insecta: Coleoptera: Scarabaeidae), were used as the ...

Tópico(s): Scarabaeidae Beetle Taxonomy and Biogeography

2007 - Oxford University Press | Environmental Entomology

Artigo Acesso aberto Revisado por pares

José Luis Marín‐Muñiz, Irma Zitácuaro-Contreras, Gonzalo Ortega-Pineda, Luis Manuel Álvarez-Hernández, Karina Elizabeth Martínez-Aguilar, Aarón López-Roldán, Sergio Aurelio Zamora Castro,

The use of constructed wetlands (CWs) for wastewater treatment has earned high interest around the world. However, innovations to improve its removal efficiency and adoption have been suggested in the last decades. For instance, the use of ornamental flowering plants (OFP), which make wetland treatment systems more aesthetic and is an option for the production of commercial flowers while the water is cleansed. The objectives of this study were to identify through a bibliometric analysis (2000–2022) ...

Tópico(s): Wastewater Treatment and Reuse

2023 - Multidisciplinary Digital Publishing Institute | Processes

Artigo Acesso aberto Revisado por pares

Alejandro Cervantes‐Reyes, Alejandra Núñez-Pineda, Carlos Barrera-Díaz, Víctor Varela-Guerrero, Gonzalo Martínez‐Barrera, Erick Cuevas‐Yáñez,

Polyethylene films were separated and recovered from polyethylene–aluminum composites derived from recycling multilayer postconsumer aseptic packaging. A brief study about the separation process by dissolving PE–aluminum (PE–Al) composites into a series of organic solvents with a combination of time and temperature is presented. Through this procedure, 56% polyethylene is recovered from this kind of composites in optimized conditions. DSC and TGA studies were performed to determine the thermal stability ...

Tópico(s): Material Properties and Processing

2015 - Elsevier BV | Waste Management

Revisão Brasil Produção Nacional

Luiz Laureno Mafra, Inés Sunesen, Estela Pires, Silvia M. Nascimento, Gonzalo Álvarez, José Ernesto Mancera Pineda, Gladys Torres, Olga Carnicer, José Alexis Huamaní Galindo, Sonia Sánchez Ramírez, Ana Martínez-Goicoechea, Dilcia Morales-Benavides, Lorelys Valerio-González,

Public awareness about Benthic Harmful Algal Blooms (BHABs) and their negative impacts has increased substantially over the past few decades. Even so, reports of BHABs remain relatively scarce in South America (SA). This paper provides a comprehensive overview of the current state of knowledge on BHABs in the continent, by integrating data from published articles, books, and technical reports. We recorded ∼300 different occurrences of potentially toxic BHAB species over the Caribbean, Atlantic and ...

Tópico(s): Marine Biology and Ecology Research

2023 - Elsevier BV | Harmful Algae

Artigo Acesso aberto Revisado por pares

José Arturo Schlickmann-Tank, Óscar Morales-Galván, Joel Pineda-Pineda, Gonzalo Espinosa-Vázquez, María Teresa Colinas-León, Mateo Vargas,

The aphid Melanaphis sacchari/sorghi is considered the most important pest of sorghum cultivation in Mexico. It can cause losses in production of up to 100%. This research was conducted at the Universidad Autonoma Chapingo during 2018 and 2019 with the objective of determining the relationship between chemical fertilization in sorghum and M. sacchari/sorghi (Hemiptera: Aphididae) populations. Different levels of nitrogen (125, 250 and 500 kg ha-1), phosphorus (19.5, 39 and 78 kg ha-1) and potassium ( ...

Tópico(s): Insect Pest Control Strategies

2020 - Centro Editorial of Facultad de Ciencias Agrarias, Universidad Nacional de Colombia | Agronomía Colombiana

Artigo Acesso aberto Revisado por pares

Scott A. Halperin, Lingyun Ye, Donna MacKinnon‐Cameron, Bruce R. Smith, Pedro Cahn, Guillermo M. Ruiz‐Palacios, Aamer Ikram, Fernando Laņas, M. Lourdes Guerrero, Sergio Raúl Muñoz Navarro, Omar Sued, Dmitry Lioznov, Vitalina Dzutseva, Ghazala Parveen, Fengcai Zhu, Laura Leppan, Joanne M. Langley, Luis Barreto, Jin-Bo Gou, Tao Zhu, Helen Mao, Luc Gagnon, Steven-Phay Tran, S. Khan, Amalia Guadalupe Becerra Aquino, Edgar Eduardo Saldaña Montemayor, Norma E. Rivera-Martínez, Víctor Casildo Bohórquez López, Jesus Abraham Simón Campos, Felipe de Jesús Pineda Cárdenas, Wei Chen, Lihua Hou, Zhe Zhang, Gonzalo Corral, Eduardo López, Ricardo Teijeiro, María Fernanda Alzogaray, Cesar Javier Zaidman, Gustavo Lopardo, Bernardo Goecke, Rosa María Feijooó Seoane, Sayed Faisal Mahmood, Ejaz Ahmed Khan, Jayed Akram, Salma Abbas, Naseem Salahuddin, E. G. Rozhkova, Tatyana Zubkova,

BackgroundThe Ad5-nCoV vaccine is a single-dose adenovirus type 5 (Ad5) vectored vaccine expressing the SARS-CoV-2 spike protein that was well-tolerated and immunogenic in phase 1 and 2 studies. In this study, we report results on the final efficacy and interim safety analyses of the phase 3 trial.MethodsThis double-blind, randomised, international, placebo-controlled, endpoint-case driven, phase 3, clinical trial enrolled adults aged 18 years older at study centres in Argentina, Chile, Mexico, Pakistan, ...

Tópico(s): Viral gastroenteritis research and epidemiology

2021 - Elsevier BV | The Lancet

Artigo Acesso aberto Revisado por pares

Javier Sánchez-Sánchez, Óliver Gonzalo‐Skok, Manuel Carretero, Adrian Pineda, Rodrigo Ramírez‐Campillo, Fábio Yuzo Nakamura,

The aim of the study was to compare the effects of an in-season five weeks of high-intensity training (HIT) with a concurrent HIT eccentric overload training (CT) program on male amateur team-sports players’ fitness performance. Twenty-two athletes were randomly assigned to HIT (n=10) or CT (n=12). Both groups completed a HIT program. The CT group also completed two-three sets of six repetitions of eccentric overload training. Before and after training, performance was assessed for change of direction ...

Tópico(s): Cardiovascular and exercise physiology

2019 - University of Zagreb | Kinesiology

Artigo Acesso aberto Revisado por pares

Lucio Antonio Ramos-Chávez, Gabriel Roldán-Roldán, Brenda García-Juárez, Dinora F. González‐Esquivel, Gonzalo Pérez de la Cruz, Benjamín Pineda, Daniela Ramírez Ortega, I. García Muñoz, Brenda Herrera, Camilo Rı́os, Saúl Gómez‐Manzo, Jaime Marcial‐Quino, Laura Sánchez‐Chapul, Paul Carrillo‐Mora, Verónica Pérez de la Cruz,

Aging is a physiological decline process. The number of older adults is growing around the world; therefore, the incidence of cognitive impairment, dementia, and other diseases related to aging increases. The main cellular factors that converge in the aging process are mitochondrial dysfunction, antioxidant impairment, inflammation, and immune response decline, among others. In this context, these cellular changes have an influence on the kynurenine pathway (KP), the main route of tryptophan (Trp) ...

Tópico(s): Bipolar Disorder and Treatment

2018 - Hindawi Publishing Corporation | Oxidative Medicine and Cellular Longevity

Artigo Acesso aberto Revisado por pares

África Holguín, Gonzalo Yebra, Leticia Martín, Alexis Pineda, Lidia Ruiz, Alma Quezada, Ana Nieto, Gustavo Escobar,

El Salvador harbours one of the largest Central American human immunodeficiency virus (HIV) epidemics, but few studies have analysed it in depth. Here, we describe the presence of transmitted drug resistance (TDR) and HIV variants in the HIV-infected adult population in El Salvador. Dried blood spots from 119 HIV-infected antiretroviral-naive adults attended in El Salvador were collected in 2011. The TDR was assessed according to the list recommended by the WHO. HIV-1 variants were described using ...

Tópico(s): HIV/AIDS Research and Interventions

2013 - Elsevier BV | Clinical Microbiology and Infection

Artigo Revisado por pares

Liliana Aguilar-Marcelino, Jesús Antonio Pineda-Alegría, David Osvaldo Salinas-Sánchez, Víctor Manuel Hernández-Velázquez, Gonzalo Iván Silva-Aguayo, Napoleón Navarro‐Tito, César Sotelo-Leyva,

The sugarcane aphid, Melanaphis sacchari Zehntner (Hemiptera: Aphididae), is the main pest of sorghum, Sorghum bicolor L. Moench (Poaceae), in Mexico. To control this insect, farmers currently use synthetic chemical insecticides, which are toxic to humans and biodiversity. However, natural products are a promising potential source of safer alternative means to control different agricultural pests. The main objective of this study was to evaluate the insecticidal effect of contact by fumigation of ...

Tópico(s): Insect and Pesticide Research

2022 - Elsevier BV | Journal of Food Protection

Artigo Revisado por pares

Cecilia A. Panek, Andrea Cecilia Bruballa, Gonzalo Ezequiel Pineda, Carlos Daniel De Brasi, Romina Jimena Fernández-Brando, María Pilar Mejías, María Victoria Carballo Calero Ramos, Marina S. Palermo,

Membrane expression of fractalkine (CX3CL1)-receptor (CX3CR1) is relevant in monocytes (Mo) because CX3CR1-CX3CL1 interactions might participate on both, homeostatic and pathologic conditions. We have previously demonstrated that CX3CR1 levels are decreased during culture and when Mo are differentiated into dendritic cells, but enhanced when differentiated into macrophages. Regarding soluble factors, lipopolysaccharide (LPS) accelerated the loss of CX3CR1, while interleukin (IL)-10 and Interferon-gamma ( ...

Tópico(s): Cytokine Signaling Pathways and Interactions

2019 - Elsevier BV | Molecular Immunology

Artigo Revisado por pares

Jonathan Gonzalo Flores-Garnica, Liliana Morales-Barrera, Gabriela Pineda-Camacho, Eliseo Cristiani‐Urbina,

The potential of Litchi chinensis seeds (LCS) for biosorption of Ni(II) ions from aqueous solutions was investigated in batch systems in terms of kinetics, equilibrium and thermodynamics. Experimental data showed that the biosorption capacity of LCS was dependent on operating variables such as solution pH, initial Ni(II) concentration, contact time, and temperature. The optimum pH value for Ni(II) biosorption was 7.5. Significant enhancement of Ni(II) biosorption was observed by increasing initial ...

Tópico(s): Clay minerals and soil interactions

2013 - Elsevier BV | Bioresource Technology

Artigo Revisado por pares

Gonzalo Gallo‐Pineda, Alicia Jiménez‐Antón, Irene Navarro‐Navarro, I. Villegas‐Romero, D. Jiménez‐Gallo,

... with amicrobial pustulosis of the folds Gonzalo Gallo-Pineda MD, Corresponding Author Gonzalo Gallo-Pineda MD [email protected] orcid.org/0000- ... for more papers by this author Gonzalo Gallo-Pineda MD, Corresponding Author Gonzalo Gallo-Pineda MD [email protected] orcid.org/0000-0003-3089- ... Puerta del Mar University Hospital, Cádiz, Spain Correspondence Gonzalo Gallo-Pineda, Unidad de Gestión Clínica de Dermatología, Puerta del ...

Tópico(s): Autoimmune Bullous Skin Diseases

2023 - Wiley | Australasian Journal of Dermatology

Artigo Acesso aberto Revisado por pares

Daniela Ramírez Ortega, Paulina Ovalle Rodríguez, Benjamín Pineda, Dinora F. González‐Esquivel, Lucio Antonio Ramos-Chávez, Gustavo Ignacio Vázquez Cervantes, Gabriel Roldán, Gonzalo Pérez de la Cruz, Araceli Díaz Ruiz, Marisela Méndez‐Armenta, Jaime Marcial‐Quino, Saúl Gómez‐Manzo, Camilo Rı́os, Verónica Pérez de la Cruz,

Abstract The immature brain is especially vulnerable to lead (Pb 2+ ) toxicity, which is considered an environmental neurotoxin. Pb 2+ exposure during development compromises the cognitive and behavioral attributes which persist even later in adulthood, but the mechanisms involved in this effect are still unknown. On the other hand, the kynurenine pathway metabolites are modulators of different receptors and neurotransmitters related to cognition; specifically, high kynurenic acid levels has been involved ...

Tópico(s): Neuroendocrine regulation and behavior

2020 - Nature Portfolio | Scientific Reports

Artigo Acesso aberto Revisado por pares

Susana Rojo-Tolosa, María Victoria González-Gutiérrez, José Antonio Sánchez-Martínez, Gonzalo Jiménez-Gálvez, Laura Elena Pineda-Lancheros, José María Gálvez-Navas, Alberto Jiménez-Morales, Cristina Pérez-Ramírez, Concepción Morales-García,

Most patients with asthma can control their symptoms with a basic standard of medical care and with maintenance and rescue medication. However, between 5% and 10% of asthmatics worldwide do not achieve control of their symptoms and have recurrent exacerbations and respiratory difficulties. The objective of the study was the real-life evaluation of the clinical improvement of patients with severe eosinophilic asthma treated with omalizumab, together with the search for biomarkers associated with ...

Tópico(s): Allergic Rhinitis and Sensitization

2023 - Multidisciplinary Digital Publishing Institute | Pharmaceutics

Artigo Acesso aberto Revisado por pares

Jorge Alberto Aguilar-Pineda, Mazen Albaghdadi, Wanlin Jiang, Karin J. Vera-López, Rita Nieto-Montesinos, Karla Lucía F. Alvarez, Gonzalo Dávila-Del-Carpio, Badhin Gómez, Mark E. Lindsay, Rajeev Malhotra, Christian L. Lino Cardenas,

Emerging evidence suggests that males are more susceptible to severe infection by the SARS-CoV-2 virus than females. A variety of mechanisms may underlie the observed gender-related disparities including differences in sex hormones. However, the precise mechanisms by which female sex hormones may provide protection against SARS-CoV-2 infectivity remains unknown. Here we report new insights into the molecular basis of the interactions between the SARS-CoV-2 spike (S) protein and the human ACE2 receptor. ...

Tópico(s): COVID-19 Clinical Research Studies

2021 - Multidisciplinary Digital Publishing Institute | International Journal of Molecular Sciences