Andrés González-Techera, Marı́a Alicia Zón, Patricia G. Molina, Héctor Fernández, Gualberto González‐Sapienza, Fernando Javier Arévalo,
The development of immunosensors for the detection of small molecules is of great interest because of their simplicity, high sensitivity and extended analytical range. Due to their size, small compounds cannot be simultaneously recognized by two antibodies impeding their detection by noncompetitive two-site immunoassays, which are superior to competitive ones in terms of sensitivity, kinetics, and working range. In this work, we combine the advantages of magneto-electrochemical immunosensors with ...
Tópico(s): Monoclonal and Polyclonal Antibodies Research
2014 - Elsevier BV | Biosensors and Bioelectronics
Fernando Javier Arévalo, Andrés González-Techera, Marı́a Alicia Zón, Gualberto González‐Sapienza, Héctor Fernández,
Immunosensors for small analytes have been a great addition to the analytical toolbox due to their high sensitivity and extended analytical range. In these systems the analyte is detected when it competes for binding to the detecting antibody with a tracer compound. In this work we introduce the use of phage particles bearing peptides that mimic the target analyte as surrogates for conventional tracers. As a proof of concept, we developed a magneto-electrochemical immunosensor (EI) for the herbicide ...
Tópico(s): Advanced Biosensing Techniques and Applications
2011 - Elsevier BV | Biosensors and Bioelectronics
Marta Marco, Ahmed Adel Baz, Cecilia Fernández, Gualberto González‐Sapienza, Ulf Hellman, Gustavo Salinas, Álbaro Jose Nieto‐Calvache,
Tópico(s): Amoebic Infections and Treatments
2006 - Springer Science+Business Media | Parasitology Research
Elena Miró, M. Carmen Cano‐Lozano, Lourdes Espinosa Fernández, Gualberto Buela‐Casal,
This is the first study to analyze variations in time estimation during 60 h of sleep deprivation and the relation between time estimation performance and the activation measures of skin resistance level, body temperature, and Stanford Sleepiness Scale (SSS) scores. Among 30 healthy participants 18 to 24 years of age, for a 10-s interval using the production method, we found a lengthening in time estimations that was modulated by circadian oscillations. No differences in gender were found in the ...
Tópico(s): Ergonomics and Musculoskeletal Disorders
2003 - SAGE Publishing | Human Factors The Journal of the Human Factors and Ergonomics Society
Mariela Barbieri, Verónica Fernández, Gualberto González‐Sapienza, Víctor Martínez-Luaces, Alberto Nieto,
A synthetic peptide (GU4) derived from an antigen B (AgB) subunit was serologically compared with crude antigen (HCFA); immunopurified AgB and antigen 5 (Ag5), and two other synthetic peptides, for diagnosis of human cystic hydatidosis. GU4 was derived from the sequence of AgB/2, the novel AgB subunit described by us. The other two peptides: 65 (AgB mimotope) and 89–122 (Ag5 mimotope), were described by others. Antigens B and 5 showed higher diagnostic sensitivity than corresponding peptides. All sera ...
Tópico(s): Coccidia and coccidiosis research
1998 - Wiley | Parasite Immunology
Aylén Di Tocco, Gabriela V. Porcal, Gabriel Lassabe, Andrés González-Techera, Marı́a Alicia Zón, Héctor Fernández, Gualberto González‐Sapienza, Sebastián Noel Robledo, Fernando J. Arévalo,
Research on immunoassays and immunosensors is currently focused mainly on the development of strategies to amplify the resulting signal. In this sense, the development of new hapten tracers that allow simpler, more sensitive, and more reliable immunoassays is desirable. Therefore, we present the development of an electrochemical immunosensor using viral particles (phages) bound with dozens of CdS nanocrystals (CdS NCs) as an outperforming alternative to conventional competitive hapten conjugates. ...
Tópico(s): Electrochemical Analysis and Applications
2022 - Elsevier BV | Sensors and Actuators B Chemical
Manuel Fernández‐Gómez, Gualberto Asencio-Cortés, Alicia Troncoso, Francisco Martínez‐Álvarez,
This work presents a novel methodology to predict large magnitude earthquakes with horizon of prediction of five days. For the first time, imbalanced classification techniques are applied in this field by attempting to deal with the infrequent occurrence of such events. So far, classical classifiers were not able to properly mine these kind of datasets and, for this reason, most of the methods reported in the literature were only focused on moderate magnitude prediction. As an additional step, outputs ...
Tópico(s): Seismology and Earthquake Studies
2017 - Multidisciplinary Digital Publishing Institute | Applied Sciences
Gualberto González‐Sapienza, Alberto Nieto, Cecilia Fernández, Anders O ̈rn, Christer Wernstedt, Ulf Hellman,
The present work describes the purification and characterization of antigen B (AgB), the thermostable lipoprotein from E. granulosus . Native AgB was purified to homogeneity by a new strategy involving adsorption on DEAE‐Sepharose, followed by immunopurification. The purified antigen was analysed using mapped monoclonal antibodies (MoAbs) and peptide isolation by in situ digestion in gels after SDS‐PAGE. Epitope mapping of 7 MoAbs using PEPSCAN, synthetic peptides and competition studies, revealed that ...
Tópico(s): Glycosylation and Glycoproteins Research
1996 - Wiley | Parasite Immunology
Produção Nacional
Revisado por pares
João Gualberto de Cerqueira, José Henrique Fernández, Judith J. Hoelzemann, Neusa Maria Paes Leme, Cristina Tobler de Sousa,
Due to the high costs of commercial monitoring instruments, a portable sun photometer was developed at INPE/CRN laboratories, operating in four bands, with two bands in the visible spectrum and two in near infrared. The instrument calibration process is performed by applying the classical Langley method. Application of the Langley’s methodology requires a site with high optical stability during the measurements, which is usually found in high altitudes. However, far from being an ideal site, Harrison ...
Tópico(s): Atmospheric chemistry and aerosols
2014 - Elsevier BV | Advances in Space Research
M. Carmen Cano‐Lozano, Lourdes Espinosa Fernández, Elena Miró, Gualberto Buela Casal,
The main aims of this study are, on the one hand, to report on the current state of the art in research into the characteristics of sleep in depression and, on the other hand, to analyse the theoretical and practical implications of these results.We review the main findings regarding the sleep disorders linked with depression and offer data about the sensitivity and specificity of these measures. The aetiopathogenic meaning of these sleep disorders is also analysed and finally we present some of ...
Tópico(s): Sleep and related disorders
2003 - Viguera Publishers | Revista de Neurología
Richard L. Seip, Jeff S. Volek, Andreas Windemuth, Mohan Kocherla, María Luz Fernández, William J. Kraemer, Gualberto Ruaño,
Genetic factors that predict responses to diet may ultimately be used to individualize dietary recommendations. We used physiogenomics to explore associations among polymorphisms in candidate genes and changes in relative body fat (Delta%BF) to low fat and low carbohydrate diets.We assessed Delta%BF using dual energy X-ray absorptiometry (DXA) in 93 healthy adults who consumed a low carbohydrate diet (carbohydrate ~12% total energy) (LC diet) and in 70, a low fat diet (fat ~25% total energy) (LF diet). ...
Tópico(s): Epigenetics and DNA Methylation
2008 - BioMed Central | Nutrition & Metabolism
Benno Brinkhaus, Torkel Falkenberg, Aviad Haramati, Stefan N. Willich, Josephine P. Briggs, Merlin Willcox, Klaus Linde, Töres Theorell, Lisa M. Wong, Jeffery A. Dusek, Darong Wu, David M. Eisenberg, Aviad Haramati, Bettina Berger, Kathi J. Kemper, Beate Stock‐Schröer, Hedda Sützl-Klein, Ferreri Rosaria, Gary Kaplan, Harald Matthes, Gabriele Rotter, Elad Schiff, Zahi Arnon, Eckhard Hahn, Christina M. Luberto, David Martín, Silke Schwarz, Diethard Tauschel, Andrew Flower, Harsha Gramminger, Hedwig Gupta, S. N. Gupta, Annette Kerckhoff, Christian S. Keßler, Andreas Michalsen, Christian S. Keßler, Eun Sun Kim, Eun H. Jang, R Kim, Sae B. Jan, Martin Mittwede, Wiebke Mohme, Eran Ben‐Arye, Massimo Bonucci, Bashar Saad, Thomas Breitkreuz, E. Rossi, Rejin Kebudi, Michel Daher, S. Razaq, Nahla Gafer, Omar Nimri, Mohamed Hablas, Gunver S. Kienle, Noah Samuels, Michael Silbermann, Lena Bandelin, Anna-Lena Lang, Eva Wartner, C. Holtermann, Maxwell Binstock, Robert Riebau, Edin Mujkanovic, Holger Cramer, Romy Lauche, Andres Michalsen, Lesley Ward, Holger Cramer, D. Irnich, Wolfram Stör, Geoffrey Burnstock, Hans‐Georg Schaible, Thomas Ots, Jost Langhorst, Romy Lauche, Tobias Sundberg, Torkel Falkenberg, Catherina Amarell, Catherina Amarell, Melanie Anheyer, Marion Eckert, Marion Eckert, Mercedes Ogal, Marion Eckert, Catherina Amarell, Annette Schönauer, Birgit Reisenberger, Bernhard Brand, Dennis Anheyer, Gustav Dobos, Matthias Kroez, David Martín, Harald Matthes, Aldo Ammendola, Jun J. Mao, Claudia M. Witt, Yufei Yang, Gustav Dobos, Miriam Oritz, Markus Horneber, Petra Voiß, Birgit Reisenberger, Alexandra von Rosenstiel, Marion Eckert, Mercedes Ogal, Catharina Amarell, Melanie Anheyer, F. Schad, Marc Schläppi, Matthias Kröz, Arndt Büssing, Gil Bar‐Sela, Harald Matthes, Elad Schiff, Eran Ben‐Arye, Zahi Arnon, David Avshalomov, Samuel Attias, Annette Schönauer, Aviad Haramati, Claudia M. Witt, Benno Brinkhaus, Sian Cotton, Miek C. Jong, Mats Jong, Christian Scheffer, Aviad Haramati, Diethard Tauschel, Friedrich Edelhäuser, Abdullah Al-Bedah, Myeong Soo Lee, Mohamed Khalil, K. Ogawa, Yoshiharu Motoo, Junsuke Arimitsu, Masao Ogawa, Genki Shimizu, Rainer Stange, Karin Kraft, Kenny Kuchta, Kenji Watanabe, Diane Bonin, Arndt Büssing, Harald Gruber, Sabine C. Koch, Harald Gruber, Urs Pohlmann, Christine Caldwell, Barbara Krantz, Ria Kortum, Lily Martin, L. Susan Wieland, Ben Kligler, Susan Gould-Fogerite, Yuqing Zhang, L. Susan Wieland, John J. Riva, Michael D. Lumpkin, Emily F. Ratner, Ping Liu, Jian Pei, Gesa-Meyer Hamme, Xiaosong Mao, Han Chouping, Sven Schröder, Josef Hummelsberger, Michael Wullinger, Marc Brodzky, Christoff Zalpour, Julia Langley, Wendy Weber, Lanay M. Mudd, Peter M. Wayne, Caitlin Elise Witt, Wolfgang Weidenhammer, Vinjar Fønnebø, Heather Boon, Amie Steel, Andrea Bugarc̀ić, Melisa Rangitakatu, Amie Steel, Jon Adams, David Sibbritt, Jon Wardle, Matthew Leach, Janet Schloss, Helene Dieze, Heather Boon, Nadine Ijaz, Merlin Willcox, Michael Heinrich, George Lewith, Andrew Flower, Bertrand Graz, Daniela Adam, Linus Grabenhenrich, Miriam Ortiz, Sylvia Binting, Thomas Reinhold, Benno Brinkhaus, Susanne Andermo, Tobias Sundberg, Torkel Falkenberg, Johanna Hök Nordberg, Maria Arman, Manoj Bhasin, Xueyi Fan, Towia A. Libermann, Gregory L. Fricchione, John W. Denninger, Herbert Benson, Bettina Berger, Rainer Stange, Andreas Michalsen, David Martín, Inge Boers, Arine M. Vlieger, Miek C. Jong, Benno Brinkhaus, Michael Teut, Alexander Ullmann, Miriam Ortiz, Gabriele Rotter, Sylvia Binting, Fabian Lotz, Stephanie Roll, Claudia Canella, Michael Mikolasek, Matthias Rostock, J. Beyer, Matthias Gückenberger, Josef Jenewein, Esther Linka, Claudia Six, Sarah Stoll, Roger Stupp, Claudia M. Witt, Elisabeth Chuang, Ben Kligler, M. Diane McKee, Holger Cramer, Romy Lauche, Petra Klose, Silke Lange, Jost Langhorst, Gustav Dobos, Vincent CH Chung, H L Wong, Xin Yu Wu, Grace Y. G. Wen, Robin S.T. Ho, Jessica Y. L. Ching, Justin C. Y. Wu, Amanda Bulette Coakley, Jane Flanagan, Christine Donahue Annese, Joanne Empoliti, Zishan Gao, Xugang Liu, Shuguang Yu, Xianzhong Yan, Fanrong Liang, Christoph D. Hohmann, Nico Steckhan, Thomas Ostermann, Arion Paetow, Evelyn Hoff, Andreas Michalsen, Xiao-Yang Hu, Ruohan Wu, Martin Logue, Clara Blonde, Lily Y. Lai, Beth Stuart, Andrew Flower, Yutong Fei, Michael Moore, Jianping Liu, George Lewith, Xiao-Yang Hu, Ruohan Wu, Martin Logue, Clara Blonde, Lily Y. Lai, Beth Stuart, Andrew Flower, Yutong Fei, Michael Moore, Jianping Liu, George Lewith, Michael Jeitler, Hannah Zillgen, Manuel Högl, Nico Steckhan, Barbara Stöckigt, Georg Seifert,
We are excited to present the abstracts of the keynote speakers, parallel sessions and oral and poster presentations of the World Congress on
BioMed Central
Gualberto Ruaño, Andreas Windemuth, Mohan Kocherla, Theodore R. Holford, María Luz Fernández, Cassandra E. Forsythe, Richard J. Wood, William J. Kraemer, Jeff S. Volek,
Diets that restrict carbohydrate (CHO) have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction.We screened for genetic associations ...
Tópico(s): Metabolism, Diabetes, and Cancer
2006 - BioMed Central | Nutrition & Metabolism
Lourdes Espinosa Fernández, Elena Miró, MóCarmen Cano, Gualberto Buela‐Casal,
Tópico(s): Diverse Music Education Insights
2003 - Elsevier BV | Acta Psychologica
J. C. Fernandez, P. Gamboa, I Jáuregui, Gualberto González‐Sapienza, I. Antépara,
Contact DermatitisVolume 27, Issue 4 p. 262-262 Concomitant sensitization to enoxolone and mafenide in a topical medicament J. C. Fernandez, J. C. Fernandez Dispensario Ledo-Artetxe. Bilbao. SpainSearch for more papers by this authorP. Gamboa, P. Gamboa Dispensario Ledo-Artetxe. Bilbao. SpainSearch for more papers by this authorI. Jáuregui, I. Jáuregui Dispensario Ledo-Artetxe. Bilbao. SpainSearch for more papers by this authorG. González, G. González Dispensario Ledo-Artetxe. Bilbao. SpainSearch ...
Tópico(s): Synthesis and properties of polymers
1992 - Wiley | Contact Dermatitis
Micaela Boffadossi, Aylén Di Tocco, Gabriel Lassabe, Macarena Pírez-Schirmer, Sebastián Noel Robledo, Héctor Fernández, Marı́a Alicia Zón, Gualberto González‐Sapienza, Fernando J. Arévalo,
The development of new electrochemical immunosensors for the detection of environmental contaminants is of great interest due to their simplicity, high sensitivity, and extended analytical range. Because of the antibody is immobilized on the electrode, it is important to determine its loss of reactivity after immobilization. In this work, two aspects were addressed. First, we developed a new methodology based on electrochemical impedance (EI) to determine the kinetic parameters associated with immunoreactions ...
Tópico(s): Marine Toxins and Detection Methods
2020 - Elsevier BV | Electrochimica Acta
Silvia García González, Martín Fló, Mariana Margenat, Rosario Durán, Gualberto González‐Sapienza, Martín Graña, John Parkinson, Rick M. Maizels, Gustavo Salinas, Beatriz Álvarez, Cecilia Fernández,
The cestode Echinococcus granulosus, the agent of hydatidosis/echinococcosis, is remarkably well adapted to its definitive host. However, the molecular mechanisms underlying the successful establishment of larval worms (protoscoleces) in the dog duodenum are unknown. With the aim of identifying molecules participating in the E. granulosus-dog cross-talk, we surveyed the transcriptomes of protoscoleces and protoscoleces treated with pepsin at pH 2. This analysis identified a multigene family of secreted ...
Tópico(s): Polyamine Metabolism and Applications
2009 - Public Library of Science | PLoS ONE
Juan Carlos Sierra, Gustavo Luna‐Villegas, Gualberto Buela‐Casal, Augusto Fernández‐Guardiola,
The aim of this single-blind study was to evaluate the residual effects of a 10-mg dose of diazepam on cortical activation 11 h after oral intake. The electroencephalographic segments (from O1-O2) delimited by a sequence of photic stimuli presented every 10 sec during a simple reaction-time task (36 min duration) were arbitrarily classified into nine cerebral patterns (EEGP). EEGP segment classifications were grouped into six peri-stimulus transitions expressed in percentages: alpha-blockade; alpha- ...
Tópico(s): Memory and Neural Mechanisms
1997 - SAGE Publishing | Journal of Psychopharmacology
Produção Nacional
María del Carmen Cano Lozano, Elena Miró, Lourdes Espinosa Fernández, Gualberto Buela‐Casal,
The objective of the present study is to analyse the relationship between several subjective parameters of sleep quantity and sleep quality and dysphoric mood in healthy subjects under normal conditions. The sample was composed of 257 university students. A questionnaire about sleep habits and the Beck Depression Inventory were carried out. There were significant differences in dysphoric mood according to habitual sleep duration but not to necessary sleep duration. The subjects who habitually sleep ...
Tópico(s): Sleep and Wakefulness Research
2004 - National University of Distance Education | Revista de Psicopatología y Psicología Clínica
José Navarrete Cortés, Juan Antonio Fernández-López, Alfonso López-Baena, Raúl Quevedo-Blasco, Gualberto Buela‐Casal,
In this study, we carried a classification by country based on the analysis of the scientific production of psychology journals. We analyzed a total of 108,741 documents, published in the Web of Science. The indicators used were the Weighted Impact Factor, the Relative Impact Factor, the Citation Rate per article and the articles published in the top five journals of the Journal Citation Report (JCR). The results indicate that Spain has the highest percentage of articles in the top five journals ...
Tópico(s): Educational theories and practices
2010 - Pontifical Xavierian University | Universitas Psychologica
Bianca N. Valdés‐Fernández, Jorge Ducongé, Ana M. Espino, Gualberto Ruaño,
Abstract Vaccines represent preventative interventions amenable to immunogenetic prediction of how human variability will influence their safety and efficacy. The genetic polymorphism among individuals within any population can render possible that the immunity elicited by a vaccine is variable in length and strength. The same immune challenge (virus and/or vaccine) could provoke partial, complete or even failed protection for some individuals treated under the same conditions. We review genetic ...
Tópico(s): Immunotherapy and Immune Responses
2021 - Wiley | BioEssays
Ramón Arce Fernández, Francisca Fariña Rivera, Gualberto Buela,
The Spanish Law 30/1995 concerning civil liability in motor vehicle accidents (MVA) has included, under the precept of moral damage, the compensation of victims of psychological injury. The literature has identified PTSD and the indirect measurements or secondary disorders i.e., depression and dystimia, as psychological injury of an MVA. Nevertheless, under civil law, the diagnosis of PTSD alone does not constitute sufficient evidence given that in legal terms faking or false testimony must be detected ...
Tópico(s): Psychosomatic Disorders and Their Treatments
2008 - Konrad Lorenz Fundación Universitaria | Revista Latinoamericana de Psicología
Martín A. Rossotti, Andrés González-Techera, Julio Guarnaschelli, Lucía Yim, Ximena Camacho, Marcelo Fernández, Pablo Cabral, Carmen Leizagoyen, José A. Chabalgoity, Gualberto González‐Sapienza,
Recombinant single domain antibodies (nanobodies) constitute an attractive alternative for the production of neutralizing therapeutic agents. Their small size warrants rapid bioavailability and fast penetration to sites of toxin uptake, but also rapid renal clearance, which negatively affects their performance. In this work, we present a new strategy to drastically improve the neutralizing potency of single domain antibodies based on their fusion to a second nanobody specific for the complement receptor ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2015 - Landes Bioscience | mAbs
Gualberto Buela‐Casal, Lourdes Espinosa Fernández,
El objetivo planteado en este trabajo es hacer una revision sobre aquellos aspectos mas relevantes que se encuadran en el contexto de la percepcion y estimacion del tiempo dentro del ambito de la Psicologia. En primer lugar, situamos el tema ofreciendo varias razones que justifican la dimension temporal desde el punto de vista de la psicologia. Continuamos senalando las dificultades que entrana dar una definicion del concepto de tiempo, dificultad que ya fue manifestada por filosofos como San Agustin ...
Tópico(s): Psychological and Temporal Perspectives Research
2010 - CIG Media Group | Suma Psicológica
Newton Oliveira Rêgo Júnior, Luzimar Gonzaga Fernandez, Renato Delmondez de Castro, Larissa Costa Silva, Simone Andrade Gualberto, Mara Lúcia Albuquerque Pereira, Marcondes Viana da Silva,
Tópico(s): Phytochemistry Medicinal Plant Applications
2011 - INSTITUTO DE TECNOLOGIA DE ALIMENTOS | Brazilian journal of food technology/Brazilian Journal of Food Technology
Juan Carlos Sierra, Augusto Fernández‐Guardiola, Gustavo Luna‐Villegas, Gualberto Buela‐Casal,
En este trabajo se presenta una revision de los estudios mas relevantes acerca de los efectos tempranos y tardios que provoca en la atencion el uso agudo y cronico de las benzodiacepinas. Se abordan diversos aspectos metodologicos de esta linea de investigacion, asi como los resultados a los que se ha llegado. A su vez, se describe una prueba poligrafica que ha demostrado su sensibilidad para detectar la accion de los farmacos hipnoticos en los seres humanos. El articulo aparece estructurado de ...
Tópico(s): EEG and Brain-Computer Interfaces
1993 - Cologio Oficial de Psicólogos del Principado | Psicothema
Pedro Quintero-Campos, Paula Segovia-de los Santos, Ethel Ibáñez-Echevarría, Dolores Hernández Fernández de Rojas, Patricia Casino, Gabriel Lassabe, Gualberto González‐Sapienza, Ángel Maquieira, Sergi Morais,
Penicillin is one of the most widely used antibiotics to treat bacterial infections in clinical practice. The antibiotic undergoes degradation under physiological conditions to produce reactive compounds that in vivo bind self-proteins. These conjugates might elicit an immune response and trigger allergic reactions challenging to diagnose due to the complex immunogenicity. Penicillin allergy delabeling initiatives are now part of antibiotic stewardship programs and include the use of invasive and ...
Tópico(s): Allergic Rhinitis and Sensitization
2022 - Elsevier BV | Analytica Chimica Acta
Idaliz Rodríguez‐Escudero, Julio A. Cedeño, Ileana Rodríguez‐Nazario, Gledys Reynaldo Fernández, Leyanis Rodríguez‐Vera, N.K. Ponce Morales, Braulio Jiménez‐Vélez, Gualberto Ruaño, Jorge Ducongé,
Abstract Introduction Pharmacists are poised to be the health care professionals best suited to provide medication‐related consults and services based on a patient's genetics. Despite its potential benefits, the implementation of pharmacogenetic (PGx) testing into primary clinical settings has been slow among medically underserved populations. To our knowledge, this is the first time that PGx‐driven recommendations have been incorporated into a Comprehensive Medication Management (CMM) service in ...
Tópico(s): Pharmacological Effects and Toxicity Studies
2020 - Wiley | JACCP JOURNAL OF THE AMERICAN COLLEGE OF CLINICAL PHARMACY
Jorge Ducongé, Ednalise Santiago, Dagmar F. Hernández-Suárez, Mariangeli Moneró, Andrés López‐Reyes, Marines Rosario, Jessicca Y. Renta, Pablo González, Laura Ileana Fernández‐Morales, Luis Antonio Vélez‐Figueroa, Orlando Arce, Frances Marín‐Maldonado, Hector J Nunez, Kyle Melín, Stuart A. Scott, Gualberto Ruaño,
Abstract This multicenter clinical study was aimed at conducting a targeted pharmacogenomic association analysis of residual on‐clopidogrel platelet reactivity in 474 Caribbean Hispanic patients. Platelet reactivity was measured using the VerifyNow P2Y12 assay and clopidogrel resistance was defined as P2Y12 reaction units (PRUs) greater than or equal to 208. Genotyping was performed using the whole‐genome Infinium MEGA BeadChip array. An ancestry‐adjusted, weighted polygenic risk score (wPGxRS) was ...
Tópico(s): Lipoproteins and Cardiovascular Health
2021 - Wiley | Clinical and Translational Science
Produção Nacional
Revisado por pares
Javier Trujillo-Santos, Gualberto Gussoni, Telma Gadelha, Juan Francisco Sánchez Muñoz-Torrero, Manuel Barrón, Luciano Espino López, Justo Ruiz-Ruiz, Carmen Fernández‐Capitán, M.A. Lorente, Manuel Monréal,
Background: The influence of recent immobilization or surgery on mortality in cancer patients with venous thromboembolism (VTE) has not been thoroughly studied. Methods: We used the RIETE Registry data to compare the 3-month mortality rate in cancer patients with VTE, with patients categorized according to the presence of recent immobilization, surgery or neither. The major outcomes were fatal pulmonary embolism (PE) and fatal bleeding within the first 3 months. Results: Of 6,746 patients with active ...
Tópico(s): Atrial Fibrillation Management and Outcomes
2014 - Elsevier BV | Thrombosis Research