Produção Nacional
Revisado por pares
Fabiana B. Kohlrausch, Rita de Cássia Elias Estrela, Paulo Feijó Barroso, Guilherme Suarez‐Kurtz,
* There is large interindividual variability in the pharmacokinetics of protease inhibitors (PIs) among human immunodeficiency virus (HIV)-infected individuals under highly active antiretroviral therapy. * Protease inhibitor have been recently reported to be substrates of the SLCO1B1/OATP1 drug transporter. * A single nucleotide polymorphism (SNP) in the SLCO1B1 gene (521T-->C) was associated with plasma levels of lopinavir in HIV-infected individuals.* Data on the impact of three SLCO1B1 SNPs (521T-->C, 388A--> ...
Tópico(s): HIV Research and Treatment
2009 - Wiley | British Journal of Clinical Pharmacology
Produção Nacional
Revisado por pares
António Macedo, Pedro Vanalle Ferreira, Ubirajara Barroso, Guilherme T.S. Demarchi, Gilmar Garrone, Riberto Liguori, Eliana Maria Monteiro Caran, Valdemar Ortiz,
The multimodal approach to treatment of genitourinary rhabdomyosarcoma (RMS) has improved survival rates, but there is now a focus on the effect on quality of life. Our aim was to evaluate erectile function in children with rhabdomyosarcoma (RMS) who underwent chemotherapy, radiotherapy, cystectomy and continent urinary diversion.We evaluated four eligible patients (age > 14 years) from our genitourinary RMS database. In two patients the reservoir was constructed at the same time of the cystectomy and ...
Tópico(s): Urologic and reproductive health conditions
2010 - Elsevier BV | Journal of Pediatric Urology
Produção Nacional
Guilherme Barroso L. De Freitas, Durinézio José de Almeida, Emerson Carraro, Ivo Ilvan Kerppers, Guilherme A.G. Martins, Rubiana Mara Mainardes, Najeh Maissar Khalil, Iara Messias-Reason,
Capsaicin (CAP) is a secondary metabolite with high therapeutic potential. It displays several bioactive properties including hypolipidemic, antioxidant, anti-inflammatory and analgesic effects. However, CAP presents toxicity to healthy cells and poor pharmacokinetic profile, which is characterized by toxic metabolites and short half-life. In this study, CAP-loaded albumin nanoparticles were obtained by the desolvation-coacervation method. The preparation process was optimized by the application ...
Tópico(s): Advancements in Transdermal Drug Delivery
2018 - Elsevier BV | Materials Science and Engineering C
AM Madureira, José R. Ascenso, L. Valdeira, Aida Duarte, João P. Frade, Guilherme Barroso L. De Freitas, Maria‐José U. Ferreira,
Abstract A phytochemical reinvestigation of the whole plant of Euphorbia segetalis yielded five tetracyclic triterpenes: 3β-hydroxy-cycloart-25-en-24-one (1), cycloart-25-ene-3β,24-diol (2), cycloart-23-ene-3β,25-diol (3), lanosta-7,9(11),24-trien-3β-ol (4) and lanosta-7,9(11),24(31)-trien-3β-ol (5). 3β-acetoxy-cycloart-25-en-24-one (1a) and glutinol (6), lupenone (7), dammaranodienol (9), cycloartenol acetate (10), 24-methylenecycloartanol acetate (11) and β-sitosterol (12), isolated previously, were evaluated ...
Tópico(s): Bioactive Natural Diterpenoids Research
2003 - Taylor & Francis | Natural Product Research
Produção Nacional
Guilherme Barroso, Edilson Schwansee Thiele,
This article had the aim of demonstrating the physiology, diagnosis and treatment of muscle injuries, focusing on athletes and their demands and expectations. Muscle injuries are among the most common complaints in orthopedic practice, occurring both among athletes and among non-athletes. These injuries present a challenge for specialists, due to the slow recovery, during which time athletes are unable to take part in training and competitions, and due to frequent sequelae and recurrences of the ...
Tópico(s): Tendon Structure and Treatment
2011 - Brazilian Society of Orthopedics and Traumatology | Revista Brasileira de Ortopedia (English Edition)
Produção Nacional
Revisado por pares
Guilherme Barroso, Edilson Schwansee Thiele,
Este artigo tem por objetivo demonstrar a fisiologia, o diagnóstico e o tratamento das lesões musculares com foque nos atletas, suas demandas e expectativas. As lesões musculares estão entre as queixas mais comuns no atendimento ortopédico, ocorrendo tanto em atletas como em não atletas. Estas lesões caracterizam um desafio para os especialistas, haja vista a lenta recuperação que afasta o atleta dos treinamentos e competições, as frequentes sequelas e a recorrência das lesões. A maior parte das ...
Tópico(s): Shoulder Injury and Treatment
2011 - Thieme Medical Publishers (Germany) | Revista Brasileira de Ortopedia
Produção Nacional
Revisado por pares
Guilherme Barroso Mainieri, Débora P. Ronconi,
Tópico(s): Assembly Line Balancing Optimization
2012 - Springer Science+Business Media | Optimization Letters
Produção Nacional
Revisado por pares
K.E. Czelusniak, A. Brocco, Danielle Fontana Pereira, Guilherme Barroso L. De Freitas,
As plantas medicinais vêm sendo cada vez mais utilizadas devido às suas propriedades preventivas, paleativas e curativas, além de ser uma terapia alternativa que traz inúmeros benefícios aos usuários. As espécies Mikania glomerata e M. laevigata pertencem à família Asteraceae e são popularmente conhecidas como guaco sendo utilizadas no tratamento de enfermidades do trato respiratório. Além disso, as duas espécies são frequentemente confundidas ou citadas na literatura de forma errada. O presente ...
Tópico(s): Essential Oils and Antimicrobial Activity
2012 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Brasileira de Plantas Medicinais
Produção Nacional
Revisado por pares
Thaysa Ksiaskiewcz Karam, Loriangela Marceli Dalposso, Diani Meza Casa, Guilherme Barroso L. De Freitas,
A utilização de plantas medicinais no tratamento e cura de enfermidades é um recurso terapêutico muito antigo e talvez o único adotado em muitas comunidades e grupos étnicos. A família Asteraceae concentra grande número de espécies com potencial terapêutico, algumas das quais do gênero Baccharis, utilizadas na medicina popular e também na produção de fitoterápicos. Estudos relatam que a principal indicação terapêutica mencionada para estas espécies estão relacionadas com ações sobre o trato gastrintestinal. ...
Tópico(s): Food Science and Nutritional Studies
2013 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Brasileira de Plantas Medicinais
Guilherme Barroso Guedes, Abraar Karan, Hylton R. Mayer, M. Bruce Shields,
Purpose: To investigate whether a self-reported history of allergy to sulfa-based drugs is a predictor for subsequent adverse reactions to topical carbonic anhydrase inhibitors (CAIs). Methods: A retrospective case-controlled cohort study via chart review was performed on 1,287 patients with a diagnosis of glaucoma. The outcome measure was the development of an adverse reaction (either ocular, systemic, or both) within at least 30 days after receipt of 1 of 4 classes of topical glaucoma medications: ...
Tópico(s): Mast cells and histamine
2013 - Mary Ann Liebert, Inc. | Journal of Ocular Pharmacology and Therapeutics
Produção Nacional
Revisado por pares
Eduardo Feitosa, Francisco Tiago Dos S S Júnior, José Arimatéa de Oliveira Nery Neto, Luis F. Matos, Matheus H De S Moura, Thiele Osvaldt Rosales, Guilherme Barroso L. De Freitas,
The SARS-CoV-2 spread quickly across the globe.The World Health Organization (WHO) on March 11 declared COVID-19 a pandemic.The mortality rate, hospital disorders and incalculable economic and social damages, besides the unproven efficacy of the treatments evaluated against COVID-19, raised the need for immediate control of this disease.Therefore, the current study employed in silico tools to rationally identify new possible SARS-CoV-2 main protease (Mpro) inhibitors.That is an enzyme conserved among ...
Tópico(s): thermodynamics and calorimetric analyses
2020 - Ivyspring International Publisher | International Journal of Medical Sciences
Produção Nacional
Revisado por pares
Hanan Khaled Sleiman, Jeane Maria de Oliveira, Guilherme Barroso L. De Freitas,
Isoflavones are a group of secondary metabolites found in plants belonging to the class of phytoestrogens. These, because they have a chemical structure similar to the endogenous hormone 17β-estradiol, act as endocrine disruptors over the different development window periods. This study aimed to evaluate male and female reproductive systems' responses when exposed to isoflavones during the development window. It is characterized as a bibliographic review, built after analyzing clinical and preclinical ...
Tópico(s): Estrogen and related hormone effects
2021 - Elsevier BV | Biomedicine & Pharmacotherapy
Produção Nacional
Revisado por pares
Felipe Nathanael Coelho Vaz, Bárbara Luísa Fermino, Maria Vaitsa Loch Haskel, Jéssica Wouk, Guilherme Barroso L. De Freitas, Roberta Fabbri, Erik Montagna, João Batista Teixeira da Rocha, Juliana Sartori Bonini,
Tópico(s): Alzheimer's disease research and treatments
2017 - Springer Science+Business Media | Biological Trace Element Research
Produção Nacional
Revisado por pares
Alexandre Arantes Miszura, Marcos Vinícius de Castro Ferraz, Rodolfo C. Cardoso, Daniel Montanher Polizel, Gabriella Oliveira, José Paulo Roman Barroso, Luiz Guilherme Mezzena Gobato, Guilherme de Paula Nogueira, Janaína Socolovski Biava, Evandro Maia Ferreira, A. V. Pires,
This study investigated the effects of growth rates and compensatory growth on puberty attainment in Nellore heifers. Nellore heifers (n = 120), weaned at 8 ± 0.75 mo of age, were blocked by sire and BW (180 ± 8.6 kg) and assigned randomly to receive 1 of 4 treatments over a 10-mo period. Treatments included ad libitum feeding (high gain, HG), feed intake to gain 0.6 kg/d (medium gain, MG), restricted feeding (0.2 kg/d) for 4 mo followed by ad libitum feeding for 6 mo (compensatory gain, CG), and alternating ...
Tópico(s): Effects of Environmental Stressors on Livestock
2020 - Elsevier BV | Domestic Animal Endocrinology
Produção Nacional
Revisado por pares
Carlos H. Dumard, Shana Priscila Coutinho Barroso, Guilherme A. P. de Oliveira, Carlos Alberto Marques de Carvalho, André M. O. Gomes, J. Couceiro, Davis Ferreira, Dirlei Nico, Andréa C. Oliveira, Jerson L. Silva, Patricia Souza Santos,
Whole inactivated vaccines (WIVs) possess greater immunogenicity than split or subunit vaccines, and recent studies have demonstrated that WIVs with preserved fusogenic activity are more protective than non-fusogenic WIVs. In this work, we describe the inactivation of human influenza virus X-31 by high hydrostatic pressure (HHP) and analyze the effects on the structure by spectroscopic measurements, light scattering, and electron microscopy. We also investigated the effects of HHP on the glycoprotein ...
Tópico(s): Escherichia coli research studies
2013 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Dwight Assis Chaves, Susy Ricardo Lemes, Lilhian Alves de Araújo, Maria Alice Montes de Sousa, Guilherme Barroso L. De Freitas, Ruy S. Lino-Júnior, Fátima Mrué, Paulo Roberto de Melo Reis,
RESUMO O Barbatimão (Stryphnodendron adstringens) planta medicinal encontrada no bioma Cerrado apresenta propriedades físico-químicas que lhe garante importantes atividades farmacológicas tais como: anti-inflamatória, analgésica e uma atividade protetora da mucosa gástrica. A casca do tronco é a principal matéria-prima usada para o desenvolvimento de produtos medicinais. Neste estudo, o objetivo foi investigar a influência da solução aquosa da casca do barbatimão no processo de formação de vasos ...
Tópico(s): Environmental and biological studies
2016 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Brasileira de Plantas Medicinais
Produção Nacional
Amanda Paiter, Guilherme Barroso L. De Freitas, Luana Patrícia Pinto, Lucas Mateus Hass, Marco Antônio Bacellar Barreiros, André Luíz Martinez de Oliveira, Luciana Grange,
In search for a more sustainable agriculture, the use of microorganisms as a technology is increasingly being used by agriculture throughout the world. This is due to the fact that it minimizes the use of agricultural supplies reducing environmental costs and impacts, based on the beneficial and natural relationships between edaphic organisms and cultivated plants. The rhizobacteria habitat in the soil establishes biochemical relationships with the plants acting as plant growth promoters (PGPR). ...
Tópico(s): Plant tissue culture and regeneration
2019 - | Agronomy Science and Biotechnology
Produção Nacional
Revisado por pares
Alessandro R. P. Machado, Hudson Capanema Zaidan, Ana Paula Sousa Paixão Barroso da Silva, Guilherme Lopes Cavalheiro, Fábio Henrique Monteiro Oliveira, João Areis Ferreira Barbosa Júnior, Kheline Fernandes Peres Naves, Adriano Alves Pereira, Janser Moura Pereira, Nader Pouratian, Xiaoyi Zhuo, Andrew O’Keeffe, Justin Sharim, Yvette Bordelon, Laurice Yang, Marcus Fraga Vieira, Adriano de Oliveira Andrade,
Over the years, a number of distinct treatments have been adopted for the management of the motor symptoms of Parkinson's disease (PD), including pharmacologic therapies and deep brain stimulation (DBS). Efficacy is most often evaluated by subjective assessments, which are prone to error and dependent on the experience of the examiner. Our goal was to identify an objective means of assessing response to therapy. In this study, we employed objective analyses in order to visualize and identify differences ...
Tópico(s): Botulinum Toxin and Related Neurological Disorders
2016 - BioMed Central | BioMedical Engineering OnLine
Produção Nacional
Banny Silva Barbosa Correia, Lucas G. Martins, Tássia Brena Barroso Carneiro Costa, Guilherme Cruz, Ljubica Tasić,
Nuclear magnetic resonance (NMR) spectroscopy in combination with chemometrics can be applied in the analysis of complex biological samples in many ways. For example, we can analyze lipids, elucidate their structures, determine their nutritional values, and determine their distribution in blood serum. As lipids are not soluble in water, they are transported in blood as lipid-rich self-assembled particles, divided into different density assemblies from high- to very-low-density lipoproteins (HDL to ...
Tópico(s): Advanced NMR Techniques and Applications
2018 - Springer Science+Business Media | Methods in molecular biology
Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva, Lehana Thabane, Vitoria Helena de Souza Campos, Thiago Santiago Ferreira, Castilho Vitor Quirino dos Santos, Ana Maria Ribeiro Nogueira, Ana Paula Figueiredo Guimaraes Almeida, Leonardo Cançado Monteiro Savassi, Adhemar Dias de Figueiredo Neto, Carina Bitarães, Aline Cruz Milagres, Eduardo Diniz Callegari, Maria Izabel Campos Simplicio, Luciene Barra Ribeiro, Rosemary Oliveira, Ofir Harari, Lindsay A. Wilson, Jamie I. Forrest, Hinda Ruton, Sheila Sprague, Paula McKay, Christina M. Guo, Gordon Guyatt, Craig R. Rayner, David R. Boulware, Nicole Ezer, Todd C. Lee, Emily G. McDonald, Mona Bafadhel, Christopher Butler, Josue Rodrigues Silva, Mark Dybul, Edward J. Mills, Gilmar Reis, Eduardo Augusto dos Santos Moreira Silva, Daniela Carla Medeiros Silva, Castilho Vitor Quirino dos Santos, Ana Maria Ribeiro Nogueira, Ana Paula Figueiredo Guimaraes Almeida, Adhemar Dias de Figueiredo Neto, Leonardo Cançado Monteiro Savassi, Luciene Barra Ribeiro, Maria Izabel Campos Simplicio, Thiago Santiago Ferreira, Vitoria Helena de Souza Campos, Lehana Thabane, Jamie I. Forrest, Edward J. Mills, D. William Cameron, James Orbinski, Sonal Singh, Kristian Thorlund, Jonas Häggström, Heloísa A. Costa, Nayara S. Drumont, Stephanny Kelvyn Bessa, João V.B. Vieira, Vania R Campos, Rosemary Oliveira, Lineria HM Suterio, Josue Rodrigues Silva, Adelino de melo Freire, Ana Carolina Fialho Dias Rocha, Ana Paula de Faria Gonçalves, Andressa França, Carlos Eduardo Dias Igídio, Igor César de Oliveira Sousa, Iracema Luisa Quintino de Carvalho, Larissa Maria Manini Benavides, Patrícia de Oliveira Pereira, Phelipy Marques de Sousa, Sabrina de Almeida Lima, Silvia Helena Sousa Pietra Pedroso, Snaydia Viegas Resende, Wellington da Silva Rocha, Thamiris Caldeira Alves, Aline Lúcia de Jesus Martins, Amanda Gouvêa Mesquita, Amanda Larissa Alves Mendes, Anna Beatriz Oliveira Mendes, Anna Clara de Jesus Oliveira, Carolina Couto de Azevedo Cysne, Clara Bensemann Gontijo Pereira, Cecília Campos Siqueira, Ednilson Barbosa Dias, Emanuelle Cristina Soares Gonçalves, Fernanda Leal Guimarães, Flavio E Giorgeto, Gabriel Torga Saade Rodrigues, Gislânia Neres de Sousa, Júlia Campos de Rezende, Júlia Diniz Assis Moreira, Isabela Canabrava Soares, João Victor Barbosa Silveira, Joselaine Gomes de Souza, Juliana Marques Santos Ferreira, Kênia Sthéfhane Guimarães Gonçalves, Laura Campos Oliveira, Layane Maria de Almeida, Letícia Campos Siqueira, Letícia de Fátimas Costa, Lorena Gabrielle Miranda Maciel, Lorena Giovanna Silva Peixoto, Lorena Mesquita Alves, Luana Rosa Rodrigues, Leonardo Silva de Almeida, Marcela Luíza Amaral Resende Lara, Luíza Lanna França Reis, M. Horacio, Maria Eduarda Martins Soares, Maria Luiza Magalhães Parreiras, M. Siqueira, Mariana Cristina Flores Mariano, Marina Guimarães Bragatto, Matheus Andrade Almeida e Silva, Mayra Estefane Silva dos Santos, Mirele Augusta Batista Ribeiro, Nayara Santos Drumond, Pedro Hosken Fernandes Guimarães, Pollyana Maria Silva Diniz, Roberta Dumont Paiva Lopes, Rosemary Oliveira, Stephanny Kelvyn Bessa, Sheila Soares Anselmo, Tainara Silva Vieira, Tatiana Aparecida Gomes da Silva, Thais Campos Siqueira, Vânia Regina Carmo, Vitor Augusto Lima do Vale, Vitor Vilaça Oliveira, Wedsley Sander Lopes dos Santos, Aline Daniele de Almeida Abreu, Bernardo Saraiva Resende de Camargos, Camila Araújo Heringer, Daniel Jacinto Mendonça Filho, Eriane Damasia Faria de Almeida Abreu, Felipe augusto Pereira Barnabé, Felipe Alves Vieira, Gabriella Fagundes Carvalho, Higor Gomes Mussi, Hilton Cardoso Arruda Macedo, Igor Bernardes Caciquinho, João Pedro Ribeiro Santos, João Ricardo Garcia Costa, José Lauro Guimarães Cardoso, Júlia Berlim de Abreu, Lorena Rodrigues de Carvalho, Lorena Amaral de Oliveira, Luana Rocha Oliveira Matos, Marcela Ferreira Brito, Mariana Cavaliere Batista e Silva, Matheus Lucca Ângelo Costa Rodrigues, Mateus de Oliveira Ferreira, Murilo Passinati Perez, Natalia Batista Zanetti, Rafaela Ribeiro de Almeida, Sarah Jeniffer da Silva Jamar, Sofia Caporalli Barbosa, Sofia Vianna von Bentzeen Rios, Stella Silva Rosa, Thomaz Takashi Ferreira Morimoto, Verônica de Araújo Libânio costa, Vitor Augusto Alves da Silva, Amanda Cypestre Alves Batista, Ana Flávia Gomes Viana, Ângela Rodrigues Vieira Santos, Anna Luiza Ribeiro Flores, Arthur Guimarães Rodrigues Dutra, Bruna Luiza Maia, Clarisse Lourdes Nadú de Almeida, Daniel Domingues Barbosa, Daniela Medeiros, D Silva, Diuly Ane Faria Rezende, Felipe Menezes Andrade, Fernanda Rúbia Batista, Gabriela Ferreira Reis, Giovane Carvalho Constantino Ferreira de Paula, Geovani de Araújo Júnior, Henrique Amaral Fonseca Pires, Jéssica Aguilar da Silva, Isabela Lovatti Rovetta, Júlia Silva Rangel, Júlia Lima Soares de Paula, Juliana de Oliveira Costa, Lucas Júnio da Silva, Luiz Gustavo Fernandes Dias, Lívia Francino Oliveira, Lucas Rodrigues Pereira Barros, Lucas de Souza Gontijo Pessoa, Lucas Klier Silva, Maria Luísa Lara Lanza Stabile, Mariana da Rocha Assis Pinto, Nicholas Vanzin Cunha, Paloma Alister Vilela da Silva, Rafael Silva Rodrigues Soares, Thais Gomes de Oliveira, Victor Oliveira de Araújo, Wesley Costa Arcanjo, A Vanetti, Ana Carolina Araújo Lage Santos, Ariade Gomes Freitas, Felipe Viana Santos, Fernanda Freitas Pinheiro, Fernanda Perez Rocha, Filipe Viana Santos, Giulia de Jesus Marcolino, Humberto Drumond Filho, Isabela Gontijo Mendonça, Isadora Gomides Faria, José Victor Mendes Milhomem, Larissa Milagres Mol, Letícia de Fátima Costa, Marcelo Bernardes Rocha Júnior, Maria Constâncio Miranda, Nathália Euclides Gonçalves, Suzana Cristina Ricco, Thiago Araújo do Nascimento, Amanda Luiza do Espírito Santo Pinheiro, Ana Carolina Matos Ferreira, Ana Caroline Santos Silva, Ana Luiza Silva Taveira, Bruno Victor de Souza Lima, Débora Siqueira Diana, Emanuela Pontes Pereira Silveira, Francisca Lina Campos Gonçalves, Gabriel C. Costa, Geraldo César Barroso de Souza, Guilherme Aurelio D'Oliveira Alves, Isadora Luiza Teixeira Neto, Jordanna Porto Inácio, J. Silverio, Lara Silveira Marques, Larissa Martins do Nascimento, Larissa Oliveira Moreira, Lorena Luiza Soares de Oliveira, Lucas Eduardo Lessa Mussi, Lucas Medeiros Ruas, Luiza Nogueira Assis Barbosa, Luiz Otávio de Sousa, Marcelo Rodrigues da Costa Fernandes, Maria Eduarda Guimarães de Souza, Maria Thereza Figueiredo Bélem Calazans, Mariana Rodrigues Marinho de Bastos, Pedro Henrique Arcanjo Alvarenga, Quimberli Vassinave Cujuí, Rafaela Valadares Diniz, Rafael Cota Andrade Ferreira de Souza, Rita de Cássia Silva, Vinícius Alves Corrêa, Vinícius Carvalho de Oliveira, Vitória Aparecida Cunha, Viviane Costa Santos, Ana Paula Figueiredo Guimaraes Almeida, Ana Paula Guimarães Alves de Carvalho, Antônio Henrique Batista Jorge, Artur Pimenta Ribeiro, Elisângela Santos Sena, Cleide Rocha Veloso, Gonçalvino Eleutério Murta, Inara Maria Gomes Cardoso, João Warley Alves, Jorge Fernando Rocha Veloso, Joyce Souto Barbosa Pimenta de Figueiredo, Karolina Campos Sampaio Lopes, Larissa Vieira Souza, Loren Montanha Costa, Ludimila Pereira de Souza, Maria de Fátima César Lima, Maria Izabel Silveira Gonçalves, Marizete Gislaine Mendes, Mayra Darlliane Loiola Silva, Raissa Rocha e Fonseca, Samuel de Oliveira, Thiago Rodrigues Ferro, Aline Cruz Milagres, Ana Carolina Aguiar Estevam, Ana Martins de Oliveira, André Henrique de Sousa Oliveira, Carina Bitarães, Carla Stefany Oliveira França, Hayka K. Rodrigues Freire, Laís Aparecida dos Reis Gama, Laylla Michelle Pereira, Luciléia Alcântara Gomes e Silva, Patrícia Santana Assis, Regiane Aparecida de Andrade, Thaís de Paula Ferreira da Silva, Thiago de Alcântara César, Adriana Marcos Mendes Rabelo, Aline do Carmo Rosa, Ana Paula Vilas Boas Wherberth, André Gustavo Pinto de Souza, André Luiz Souza Gomes,
Background: Previous trials have demonstrated the effects of fluvoxamine alone and inhaled budesonide alone for prevention of disease progression among outpatients with COVID-19. Objective: To determine whether the combination of fluvoxamine and inhaled budesonide would increase treatment effects in a highly vaccinated population. Design: Randomized, placebo-controlled, adaptive platform trial. (ClinicalTrials.gov: NCT04727424) Setting: 12 clinical sites in Brazil. Participants: Symptomatic adults ...
American College of Physicians
Janaína Gomes‐da‐Silva, Fabiana Ranzato Filardi, Maria Regina de Vasconcellos Barbosa, José Fernando A. Baumgratz, Carlos Eduardo de Mattos Bicudo, Taciana Barbosa Cavalcanti, Marcus A. Nadruz Coelho, Andréa Ferreira da Costa, Denise Pinheiro da Costa, Eduardo Dalcin, Paulo H. Labiak, Haroldo Cavalcante de Lima, Lúcia G. Lohmann, Leonor Costa Maia, Vidal de Freitas Mansano, Mariângela Menezes, Marli Pires Morim, Carlos Wallace do Nascimento Moura, Eimear Nic Lughadha, Denílson Fernandes Peralta, Jefferson Prado, Nádia Roque, João Renato Stehmann, Lana da Silva Sylvestre, Larissa Trierveiler‐Pereira, Bruno Machado Teles Walter, Geraldo Zimbrão, Rafaela Campostrini Forzza, Fernanda Pessi de Abreu, Maria Carolina de Abreu, Vanessa Holanda Righetti de Abreu, Rafael Acuña Castillo, Edgar Augusto Lobato Afonso, Leandro de Almeida Neves Nepomuceno Agra, María F. Agra, Daniel P. P. de Aguiar, Elisa Teixeira Aires, Frank Almeda, Gracineide S.S. Almeida, Mariana M. Almeida, Nicolli Bruna Cabello de Almeida, Rafael Felipe de Almeida, Roberto B.P. Almeida, Thaís Elias Almeida, Eduardo Bezerra de Almeida, Daniela Alves, Flávio Macêdo Alves, Karina N.L. Alves, Maria B.B. Alves, Rodolfo F. Alves, Maria Clara Estanislau do Amaral, André L.S. Amaral, Leandro de Almeida Amélio, André M. Amorim, Bruno S. Amorim, Eduardo Toledo de Amorim, Vívian Oliveira Amorim, Ivanilza Moreira de Andrade, Ray S. Andrade, Thiago André, Regina Helena Potsch Andreata, Caroline Oliveira Andrino, María Betiana Ângulo, Cassiane Barroso dos Anjos, Guilherme Medeiros Antar, Mirian C.A. Antonicelli, Lorena Lana Camelo Antunes, Lidyanne Yuriko Saleme Aona, Marcelo D. Arana, João L.M. Aranha, Anderson G.A. Araújo, Andréa Onofre de Araújo, Camila C. Araújo, Cíntia Aparecida Teixeira Araújo, Filipe Maia Araújo, Mário H.T. Araújo, María Mercedes Arbo, Emily S. Arnou, Renata Asprino, Francine C. Assis, Leandro C. S. Assis, Marta Camargo de Assis, Francisco Athayde Filho, Sarah Maria Athiê‐Souza, Igor Henrique Freitas Azevedo, Lucas F. Bacci, Camilo V.O. Barbosa, Juliana Ferreira Barbosa, Rafael Gomes Barbosa‐Silva, Ian C. Barcellos, Gloria E. Barboza, Flávia Regina Baptista Barcelos, Laísa Barcelos, Kamilla L. Barreto, Fábio de Barros, Thiago Oliveira Barros, Maria Beatriz Barbosa de Barros Barreto, Cid José Passos Bastos, Cláudia Araújo Bastos, João A. N. Batista, Marcella M.I. Batista, Hortensia Pousada Bautista, Adarilda Petini Benelli, Nicolas Garcia Berguecio, Luís Carlos Bernacci, Maila Beyer, Andrea Carla Caldas Bezerra, Luísa M.P.A. Bezerra, Yuri R.L. Bezerra, Luciano B. Bianchetti, Narcísio C. Bigio, Leonardo Biral, VINICIUS FERRACINI BISSOLI, Felipe Bittencourt, Thuane Bochorny, Amabily Bohn, Lynn Bohs, Gabriel F.P. Bojacá, Abril Boldorini, Ilsi Iob Boldrini, Mônica Bolson, Juçara Bordin, Natali G. Bordon, Rafael Augusto Xavier Borges, Rodrigo L. Borges, Roseli Lopes da Costa Bortoluzzi, Claudia Petean Bove, Massimo G. Bovini, João Marcelo Alvarenga Braga, Nayara S.S. Braga, Suema Branco, Laiana M. Brauner, Denise Monte Braz, João B. A. Bringel, A. L. V. Toscano de Brito, Eliete S. Brito, Carla Poleselli Bruniera, Mônica Gomes Buchoski, William R. Buck, Norma Catarina Bueno, VINÍCIUS R. BUENO, Henrique Mallmann Büneker, Mariana de Oliveira Bünger, Maria T.A. Buril-Vital, George P. Burton, Andressa Cabral, Elsa L. Cabral, Fernanda Nunes Cabral, Tiara Sousa Cabral, Mayara K. Caddah, Claudenir Simões Caires, Taiara Aguiar Caires, Luana Silva Braucks Calazans, Diana Kelly Dias Caldas, Maria Fernanda Calió, Joel Calvo, Paulo Eduardo Aguiar Saraiva Câmara, Rodrigo Augusto Camargo, MEL C. CAMELO, Antônio Campos-Rocha, Elisa Candido, Bianca Kalinowski Canestraro, Thais S. Canto‐Dorow, Patrick de Castro Cantuária, Álison L. Cara, Gonzalo Cárdenas, Anabela Cardoso, Domingos Cardoso, J. Cardoso, Leandro Jorge Telles Cardoso, Pedro Henrique Cardoso, Andrey Lucas Cardozo, Nállarett M.D. Cardozo, Dimas Marchi do Carmo, João Afonso Martins do Carmo, Camila R. Carneiro, Cláudia Elena Carneiro, Tatiana Tavares Carrijo, Maria Beatriz Rossi Caruzo, Catarina Silva de Carvalho, Dariane A.S. Carvalho, Fernanda Antunes Carvalho, Maria Luiza Silveira de Carvalho, Jefferson Carvalho-Sobrinho, Micheline Carvalho‐Silva, Ana Carolina Devides Castello, Márcia S. Castro, I.C. Silva, Fernanda S. Catenacci, L. H. Cavalcanti, Larissa Cavalheiro, Armando Carlos Cervi, Roberta Gomes Chacon, Aline Pitol Chagas, Earl C.O. Chagas, Alain Chautems, Olivier Chauveau, Renata Nicora Chequín, Anderson Luiz Christ, Jheniffer A. Christ, Bruno B. Cidrão, Lynn G. Clark, Alexa A.O.P. Coelho, Guilherme Peres Coelho, Rubens Luiz Gayoso Coelho, Gabriel Dalla Colletta, Matheus Colli‐Silva, Adilva de Souza Conceição, Tulio C. Conceição, João Paulo S. Condack, Fernanda L. Contro, Inês Cordeiro, Luciana Silva Cordeiro, Wesley Cordeiro, Ana L.A. Côrtes, Daniel Costa, Fabiane Nepomuceno Costa, Fernanda S.N. Costa, Francisco C.P. Costa, Géssica A.G. Costa, Isabelle Gomes Cardoso Machado da Costa, Itayguara Ribeiro da Costa, Jeferson Miranda Costa, Jorge Antônio Silva Costa, José G.S. Costa, Maria T.R. Costa, Mitchel I.A. Costa, Suzana Maria Costa, Thiago Vieira Costa, Tiago Souza Costa, Maria B. Costa e Silva, James Lucas da Costa‐Lima, Matheus Martins Teixeira Cota, Yuri S. V. Couceiro, Thales Silva Coutinho, Dayvid Rodrigues Couto, Ricardo S. Couto, Anielly F. Couvo, Stephany B. Cyrillo, Luis H. Dal Molin, Cleiton Dalastra, Rafaella Georgia Lima Damasceno, Lara R.P. De Lazzari, Leonardo Paz Deble, Carolina Delfini, G. Delgado, Alfonso Delgado‐Salinas, Aline Possamai Della, Piero G. Delprete, Massimiliano Dematteis, Greta Aline Dettke, Marcelo Fernando Devecchi, Talita S. Dewes, Fernando R. Di Maio, Kauê N.L. Dias, Micheli C. Dias, Pedro Henrique dos Santos Dias, Yani Aranguren, Vinícius A.O. Dittrich, Yoannis Domínguez, Marcos da Costa Dórea, Mariane P. Dorneles, Stefan Dreßler, Marília Cristina Duarte, Juan David Tovar, Julie Henriette Antoinette Dutilh, Leo X.C. Dutra, Valquíria Ferreira Dutra, Lívia Echternacht, Lilian Eggers, Roy H.J. Erkens, Marcelo P. Eslabão, Fábio S. Espírito Santo, Hans‐Joachim Esser, Liliana Essi, Gerleni Lopes Esteves, Roberto Lourenço Esteves, Joel F. Everling, Cecilia Ezcurra, Marlon Garlet Facco, Andrea A. Cabaña Fader, Marcus J.A. Falcão, Laura Bubantz Fantecelle, Gabriela E. Farco, Allan Laid Alkimim Faria, Ana P.G. Faria, Aparecida Donisete de Faria, Maria Tereza de Marsillac Pasinato, Jair Eustáquio Quintino Faria, Simone Farias, Rosana Farias‐Singer, Maria Ana Farinaccio, Ana Clara Gonçalves Fernandes, Fernando Fernandes de Oliveira Neto, José Manuel Fernandes, Rozijane Santos Fernandes,
Abstract The shortage of reliable primary taxonomic data limits the description of biological taxa and the understanding of biodiversity patterns and processes, complicating biogeographical, ecological, and evolutionary studies. This deficit creates a significant taxonomic impediment to biodiversity research and conservation planning. The taxonomic impediment and the biodiversity crisis are widely recognized, highlighting the urgent need for reliable taxonomic data. Over the past decade, numerous ...
Wiley
Produção Nacional
Luisa Fermino B aacute rbara, C. Michele, Guilherme Barroso L. De Freitas, Cl aacute udio Francisco Nunes Weber, Picada Pereira Romaiana, Batista Teixeira da Rocha Jo atilde o, Sartori Bonini Juliana,
Curative effects of Ginkgo biloba L. have been recognized for centuries, dating back to traditional Chinese medicine which used crushed leaves to treat several health problems. Although G. biloba L. has several known and investigated activities, the antioxidant activity of its extract (EGb 761) is particularly relevant because reactive oxygen (ROS) and reactive nitrogen (RNS) species are constantly produced in aerobic organisms. Currently, the exploitation of the antioxidant activity of G. biloba extract ...
Tópico(s): Alzheimer's disease research and treatments
2015 - Academic Journals | African Journal of Pharmacy and Pharmacology
Produção Nacional
Revisado por pares
Simone Sacramento Valverde, Bruna Celeida S. Santos, Temistocles Barroso de Oliveira, Guilherme C. Gonçalves, Orlando Vieira de Sousa,
Abstract Solidagenone (SOL) is a labdane‐type diterpenoid found in Solidago chilensis , a plant traditionally used to treat skin diseases, kidney pain and ovarian inflammation. In this study, the topical anti‐inflammatory activity of SOL was evaluated using in vivo and in silico assays. Croton oil‐, arachidonic acid (AA)‐ and phenol‐induced ear oedema mouse models were applied in the in vivo studies. Myeloperoxidase (MPO) and N ‐acetyl‐β‐D‐glucosaminidase (NAG) activities and tumour necrosis factor alpha ( ...
Tópico(s): Phytochemistry and Biological Activities
2020 - Wiley | Basic & Clinical Pharmacology & Toxicology
Produção Nacional
Revisado por pares
Poliana Cristina Spricigo, Banny Silva Barbosa Correia, Karla Rodrigues Borba, Isabela Barroso Taver, Guilherme de Oliveira Machado, Renan Ziemann Wilhelms, Luiz Henrique Keng Queiroz Júnior, Ângelo Pedro Jacomino, Luiz Alberto Colnago,
The cambuci is a native Brazilian fruit from the Atlantic Forest biome. A soft and astringent pulp, a green color, and a sweet aroma are its main characteristics. Classical food quality attributes (fresh fruit mass, fruit height, diameters, total soluble solid, titratable acidity, and ratio) and the metabolic profile from ten accessions from three different locations were analyzed herein by analytical methods (refractometry and neutralization titration) and nuclear magnetic resonance spectroscopy. ...
Tópico(s): Postharvest Quality and Shelf Life Management
2021 - Multidisciplinary Digital Publishing Institute | Molecules
Produção Nacional
Revisado por pares
RCE Estrela, AB Santoro, PF Barroso, Mari Tuyama, Guilherme Suarez‐Kurtz,
CYP3A5 genotype has no impact on the trough plasma concentrations of lopinavir and ritonavir in human immunodeficiency virus (HIV)-infected individuals on stable highly active antiretroviral therapy (HAART). This is ascribed to a drug interaction, such that ritonavir by inhibiting CYP3A activity, may occlude the pharmacokinetic consequences of functional polymorphisms in the CYP3A5 gene. In the clinical setting, where lopinavir and ritonavir are always combined, CYP3A5 genotype is of no consequence ...
Tópico(s): Pharmacogenetics and Drug Metabolism
2008 - Wiley | Clinical Pharmacology & Therapeutics
Produção Nacional
Revisado por pares
Ricardo Y. Abe, Heloísa A. Maestrini, Guilherme Barroso Guedes, Marcelo Mazza do Nascimento, Camila Ishii Iguma, Hérika Danielle de Miranda Santos, Muna Georges Nasr, Ricarte P. Lucena-Junior, Tiago S. Prata,
Abstract Evaluate real-world data of outcomes from selective laser trabeculoplasty (SLT) performed in different regions of Brazil and investigate potential predictors of success associated with treatment. Multicenter retrospective case series with patients who underwent a primary SLT procedure. A total of 835 eyes from 835 patients were included. The mean follow-up was 916.8 ± 563.0 days. The mean age was 64.5 ± 14.9 years and 56.6% were women. We observed an intraocular pressure reduction comparing ...
Tópico(s): Retinal Imaging and Analysis
2022 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Arthur Guerra de Andrade, Paulina do Carmo Arruda Vieira Duarte, Lúcia Pereira Barroso, Raphael Nishimura, Denis Guilherme Alberghini, Lúcio Garcia de Oliveira,
To assess the frequency of drug use among Brazilian college students and its relationship to gender and age.A nationwide sample of 12,721 college students completed a questionnaire concerning the use of drugs and other behaviors. The Alcohol, Smoking and Substance Involvement Screening Test (ASSIST-WHO) criteria were used to assess were used to assess hazardous drug use. A multivariate logistic regression model tested the associations of ASSIST-WHO scores with gender and age. The same analyses were ...
Tópico(s): Hormonal and reproductive studies
2012 - Associação Brasileira de Psiquiatria | Brazilian Journal of Psychiatry
Produção Nacional
Revisado por pares
A.C.S. Alves, Danyelle Cristine Marini, Guilherme Barroso L. De Freitas, Durinézio José de Almeida,
Estima-se que aproximadamente 25% das drogas prescritas em todo o mundo são oriundas de espécies vegetais. Dentre as plantas com alto potencial medicinal, se destaca o Hypericum perforatum L. (HP), planta herbácea perene, pertencente à família Hypericaceae. Extratos orgânicos e aquosos de HP têm sido utilizados na medicina popular e em testes pré-clínicos para o tratamento e prevenção de diversas doenças através de efeitos nefroprotetores, atividades antioxidante, antifúngica, ansiolítica, antiviral ...
Tópico(s): Synthesis of Organic Compounds
2014 - UNIVERSIDADE EST.PAULISTA JÚLIO DE MESQUITA FILHO | Revista Brasileira de Plantas Medicinais
Produção Nacional
Lucas Abreu Barroso, Guilherme Viana de Alencar,
Em 2014 comemora-se os 50 anos do Estatuto da Terra (Lei no. 4.504/1964). Editado no início da ditadura militar, o Estatuto da Terra foi a fórmula encontrada para conter a pressão vinda do campo que reivindicava uma política governamental com fulcro na Reforma Agrária. Embora principalmente concebido visando á distribuição de terras na Região Norte, após a redemocratização, em 1985, os movimentos campesinos mostraram-se presentes nas cinco regiões do país, demonstrando que a luta pela terra ocupava ...
Tópico(s): Rural Development and Agriculture
2014 - | Revista Brasileira de Gestão Ambiental e Sustentabilidade
Produção Nacional
Revisado por pares
Antônio Mendes de Oliveira Neto, Jamil Constantin, Rubem Silvério de Oliveira, A.L.L. Barroso, Guilherme Braga Pereira Braz, Naiara Guerra, Eliezer Antonio Gheno,
ABSTRACT The aim of this work was to evaluate the selectivity of fomesafen alone or in a tank mixture with other preemergent herbicides, with or without S-metolachlor application in early postemergence in cotton plant, cultivar DP 555 BG RR(r). The design utilized was a randomized complete block, organized in a split-plot arrangement, with four replications. For that, 24 herbicides were evaluated with fomesafen (0.45 and 0.625 kg ha-1), prometryn (1.25 kg ha-1), diuron (1.25 kg ha-1), trifluralin (1. ...
Tópico(s): Growth and nutrition in plants
2015 - Sociedade Brasileira da Ciência das Plantas Daninhas | Planta Daninha