Hiddo J.L. Heerspink, C. David Sjöström, Niels Jongs, Glenn M. Chertow, Mikhail Kosiborod, Fan Fan Hou, John J.V. McMurray, Peter Rossing, Ricardo Correa‐Rotter, Raisa Kurlyandskaya, Bergur V. Stefánsson, Robert D. Toto, Anna Maria Langkilde, David C. Wheeler, Hiddo J.L. Heerspink, David C. Wheeler, Glenn M. Chertow, Ricardo Correa‐Rotter, Tom Greene, Fan Fan Hou, John J.V. McMurray, Peter Rossing, Robert D. Toto, Bergur V. Stefánsson, Anna Maria Langkilde, Laura Maffei, Pablo Raffaele, S. Solís, César A. Arias, Dov Aizenberg, Carolina Lúquez, Cesar Javier Zaidman, Natalia Cluigt, M. Mayer, A Alvarisqueta, A. Wassermann, Rafaël Maldonado, J. Bittar, M. Maurich, L.E. Gaite, Nicole Garcia, Leonardo Sivak, Pablo Ramallo, Juan Carlos Santos, Ruben Garcia Duran, Juan Oddino, A Marañón, Lília Nigro Maia, Dánae Duana Ávila, Elvino Barros, Maria H Vidotti, Daniel Panarotto, Irene de Lourdes Noronha, Luiz Alberto Andreotti Turatti, Luciane Mônica Deboni, María Eugênia Fernandes Canziani, Miguel C. Riella, Marcelo Rodrigues Bacci, Raphael Paschoalin, R. J. Franco, João Carlos Goldani, Eric St-Amour, Ann Steele, Ronald Goldenberg, S.B. Pandeya, Harpreet S. Bajaj, David Z.I. Cherney, Stéphanie Kaiser, James Conway, Sharron Chow, G.S. Bailey, Jean‐Philippe Lafrance, Jonathan Winterstein, Serge Cournoyer, Daniel Gaudet, F. Madore, Robyn L. Houlden, Ashley Dowell, Michel R. Langlois, Nicola Muirhead, Hasnain Khandwala, Anna S. Levin, Fan Fan Hou, Ying Xue, Zuo Li, Chuan‐Ming Hao, Zhaohui Ni, Xing Changying, N Chen, Yugang Dong, Rong Zhou, Xiao Xu, Yiping Zou, Chu Wang, Liu B, Qian Chen, Miao Lin, Qin Luo, David Zhang, Jing Wang, Meng Chen, X Wang, Aihua Zhong, Jun Dong, Chunyan Zhu, T Yan, Ping Luo, Yan Ren, Pearl Pai, D. LI, R Zhang, Jian Zhang, Meiling Xu, Yongze Zhuang, Yaozhong Kong, Xin Yao, Xiaomei Peng, Frederik Persson, Troels Krarup Hansen, Rikke Borg, Ulrik Pedersen‐Bjergaard, Dorte Hansen, Mads Hornum, Hermann Haller, Gerhard Klausmann, Diethelm Tschöpe, Thinus F. Kruger, Peter L. Gross, Christian Hugo, Nicholas Obermüller, Ludger Rose, Patrick Mertens, Helga Zeller-Stefan, Andreas Fritsche, Lutz Renders, Jürgen Müller, Klemens Budde, Bernd Schröppel, István Wittmann, Péter Vörös, Marek Dudáš, Ádám G. Tabák, Róbert Kirschner, Annamária Letoha, I. Balku, Zs. Hermányi, Gábor Zakar, I Mezei, Gergely Nagy, J Lippai, Andrea H. Németh, Dinesh Khullar, Prakash Kikkeri Gowdaiah, Edwin Fernando Mervin, V. Rao, D. Dewan, Vatsalya Maddi, Milind Vyawahare, Rakesh Pulichikkat, Satyendra Kumar Sonkar, Vivek Gupta, Samarth Agarwal, Arthur Asirvatham, Anita Ignatius, Sanjay Chaubey, Sreelatha Melemadathil, H. Alva, Y. Kadam, Hiroaki Shimizu, A Sueyoshi, Hiroaki Takeoka, Yuko Abe, Takumi Imai, Yukiko Onishi, Yasuko Fujita, Yukichi Tokita, Y Makita, Akira Idogaki, Ryo Koyama, H Kikuchi, Naoki Kashihara, Toshimasa Hayashi, Yukio Ando, Tsuyoshi Tanaka, Motohiro Shimizu, Sumi Hidaka, Tomohito Gohda, Kouichi Tamura, Masami Abe, Yoshito Kamijo, Toshiyuki Imasawa, Yasunori Takahashi, Mikihiro Nakayama, Masayoshi Tomita, F. Hirano, Mikihiro Nakayama, Yasushi Fukushima, Arihiro Kiyosue, Sumiko Kurioka, Eri Imai, Kazuo Kitagawa, Masako Waki, Jun Wada, K. Uehara, Hirotsugu Iwatani, Keiko Ota, Satomi Shibazaki, Kouichi Tamura, Kan Katayama, Ichiei Narita, Masahiro Iinuma, Satoko Matsueda, Shoji Sasaki, Alex Yokochi, Tatsuo Tsukamoto, Teizo Yoshimura, Soyoung Kang, S Lee, Chun Soo Lim, Ho Jun Chin, Kwon Wook Joo, Suji Han, Tara I. Chang, Soo-Hyun Park, Hyunmi Park, C W Park, Bin Han, Dawood Darbar, Sung-Sik Yoon, Won Jung Kim, Suck Won Kim, Dongsu Ryu, Ricardo Correa‐Rotter, Sergio Saul Irizar Santana, G. Hernandez Llamas, Rafael Valdez-Ortiz, N. Nicolas, Guillermo González-Gálvez, José Roberto Lazcano Soto, T. Bochicchio Riccardelli, E Llamas, Denisse Ramos Ibarra, Maira Gabrielle Silva Melo, José Gerardo González‐González, Jose Hector Sanchez Mijangos, Margarida Robalo, Armando García Castillo, Hélard Manrique, J. Farfan, Ramón Vargas, Alicia Valdivia, A. Dextre, Elizabeth Escudero, Jorge R Calderon Ticona, Liberty Gonzales, Jaime E. Villena, Luís León, Guilherme Eckhardt Molina, Alene Saavedra, Emanuel Pimenta Garrido, Hugo Arbañil, Sofia Marquez, Juan Carlos de Vicente, Rey Isidto, A.J. Villaflor, M.A. Gumba, Louie Tirador, Rhea Severina Comia, Rosa Allyn Sy, Mitchell Guanzon, Grace Aquitania, Norman Cornelio De Asis, A A Silva, Maggie Lim, Romina Danguilan, Michał Nowicki, H Rudzki, Karenia Landa, Izabela Kucharczyk-Bauman, B. Gogola-Migdal, M. Golski, Anna Olech-Cudzik, Tomasz Stompór, T. Szczepanik, B Miklaszewicz, R Ściborski, Marek Kuźniewski, Kazimierz Ciechanowski, Danuta Wrońska, Wiesław Klatko, Stanisław Mazur, Grazyna Popenda, Marcin Myślicki, Л. З. Болиева, Stefanie Berns, А. S. Galyavich,
Mortality rates from chronic kidney disease (CKD) have increased in the last decade. In this pre-specified analysis of the DAPA-CKD trial, we determined the effects of dapagliflozin on cardiovascular and non-cardiovascular causes of death.DAPA-CKD was an international, randomized, placebo-controlled trial with a median of 2.4 years of follow-up. Eligible participants were adult patients with CKD, defined as a urinary albumin-to-creatinine ratio (UACR) 200-5000 mg/g and an estimated glomerular filtration ...
Oxford University Press
Katherine R. Tuttle, Sibylle J. Hauske, María Eugênia Fernandes Canziani, Maria Luiza Caramori, David Z.I. Cherney, Lisa Cronin, Hiddo J.L. Heerspink, Christian Hugo, Masaomi Nangaku, Ricardo Correa‐Rotter, Arnold Silva, Shimoli Shah, Zhichao Sun, Dorothea Urbach, Dick de Zeeuw, Peter Rossing, Katherine R. Tuttle, Sibylle J. Hauske, María Eugênia Fernandes Canziani, Maria Luiza Caramori, David Z.I. Cherney, Lisa Cronin, Hiddo J.L. Heerspink, Christian Hugo, Masaomi Nangaku, Ricardo Correa‐Rotter, Arnold Silva, Shimoli Shah, Zhichao Sun, Dorothea Urbach, Dick de Zeeuw, Peter Rossing, Cheuk‐Chun Szeto, Diego Echeverri, Edouard Martin, Ming Li Yee, William Wah, Ray Wang, Bobby Chacko, Shriram Swaminathan, Richard J. MacIsaac, Hikaru Hashimura, Glenn M. Ward, Katrien De Vusser, Kathleen Claes, Dirk Kuypers, Björn Meijers, Amaryllis H. Van Craenenbroeck, Robert Hilbrands, Corinne Debroye, Karl Martin Wissing, Michel Jadoul, Nathalie Demoulin, Serge Treille De Grandsaigne, Ishak Beklevic, Diane Marcoux, F Liénart, Claude Daper, V de Brouckère, Mercédès Heureux, João Soares Felício, Karem Miléo Felício, Daniella Leite, Franciane Trindade Cunha de Melo, Natércia Neves Marques de Queiroz, Ana Carolina Souza, Jocyelle Vieira, Roberto Jorge da Silva Franco, Adriana Aparecida Mendes, Giovana Picolli, Luís Henrique Santos Canani, Carla Sartori, Adriana Valenti, Freddy G. Eliaschewitz, Renata Luísa Bona, Denise Reis Franco, Denise Ludovico Costa de Castro, Vanessa Magalhaes, Marcelo G. de Oliveira, Célia Regina Sampaio, Guilherme Visconti, Bruno Halpern, Camila Nihei, Bruna V. Pessoa, Carlos Eduardo Seraphim, Daniel Barbedo Vasconcelos Santos, Cláudia Brito, J. B. Douverny, Marina Colella, Cristina Gazeta, Monique Vercia, Renato Watanabe, Theodora Temelkova, Dimo Kjurkchiev, Silviya Statkova, Iliya Popov, Radosveta Radeva, Lachezar Arabadzhiev, Mariya Binova, Aleksandar Bosilkov, Neli Koleva-Stoicheva, Ivaylo Ivanov, З. А. Иванова, Viktoria Kotseva, Petar Spasov, Ivaylo Tsvetkov, Shivinder Jolly, G. Howard Bailey, Zhiming Ye, Jianying Niu, Hongmei Li, Qing Wu, Bing Liao, Chuan‐Ming Hao, Lingyun Lai, Yunyu Xu, Min Zhang, Yiwen Li, Bo Liu, Lina Shao, Wei Chen, Haishan Wu, Marian Pirchala, Iva Skarpova, Marketa Hraskova, Simoneta Soukupova, Lucie Veberova, Tomas Drasnar, Matej Falc, Blazej Racz, Stepan Votocek, Danica Weissova, Lenka Syc-Krivanova, Dagmar Slezak, Ilkka Kantola, Sakari Nieminen, Milla Anttonen, Jyrki Taurio, Jorma Lahtela, Vasileios Tsimihodimos, Olga Balafa, Evangelia Dounousi, S.-F. Sakkou, Nikolaοs Tentolouris, Christos Siafarikas, Evangelia Siami, Ioannis Doupis, Theodoros Angelopoulos, Christodoulos Georgoulias, Dénes Páll, Regina Esze, Tamás Köbling, Zita Váradi, Noémi Zsíros, Viktor Vass, Tímea Baló, Erika Csanyi, Ivan Ory, István Páll, Valentina Patai, Zsuzsanna Zeak, István Takács, Ákos Pethő, Balázs Szili, László Korányi, Katalin Bezzegh, József Pauer, Eva Péterfai, L. Könyves, Brigitta Szoke, Csaba Hajdú, K Kálmán, Raj Kumar Yadav, Navneet Saxena, Meenakshi Bhattacharya, Bal Krishan Sharma, Nihal Thomas, Felix Jebasingh K, Nitin Kapoor, Mathews Edatharayil Kurian, Jinson Paul, Priyadharshini Ramesh, Sheeba Varghese, Nobuyuki Shibusawa, Hiroshi Nishi, Nobuyasu Noritake, Oda T, Hideki Okamoto, Hirotake Kasuga, Hiroshi Hori, Yukiko Ito, Toshihiro Mizukoshi, Hideto Ishii, Seung Hyeok Han, Hyung Woo Kim, Kook‐Hwan Oh, Seung Seok Han, Sang Youb Han, Dae Ryong, Jin Deok Joo, Soon Kil Kwon, Hyun‐Jeong Cho, Hye‐Young Kim, Sun Moon Kim, Jung Pyo Lee, Jeonghwan Lee, Li Yuan Lee, Meng Lee Chang, S T Laang, Zhao Zhi Tan, H Ahmad Rosdi, Siti Hafizah Mohammad Ismail, Devamalar Simatherai, Ju Fan Tay, Fook Sem Wong Eddie, S. Yakob, Noorhafini Abdul Sukur, Amalina Anuar, Syaliza Md. Rasid, Irma Liyana Mushaddik, Ruslinda Mustafar, Muhammad Yusuf Abu Shamsi, Voon Ken Fong, Lydia Kamaruzaman, Rozita Mohd, Wan Rohaslizan Wan Daud, Wan Hasnul Halimi Wan Hassan, Suhaidarwani Ab Hamid, Muhammad Abdullah, Mohd Yusran Yusoff, Gandhibabu Ramanathan, K Lee, Wan Fadhilah Wan Ismail, Enrique Villegas, Rubria Ramirez Baez, Jorge Vital Lopez, Cristhian Arias Delgadillo, Marisol Herrera Marmolejo, Rosa Parra Perez, Melchor Alpízar Salazar, Ana Flores Montealegre, Jose Galvan Magaña, Minerva Gutierrez Tlapale, D Munguia, Bartlomiej J. Witczak, Lasse G. Gøransson, Inga Strand Thorsen, Clodoaido Caringal, Mario Villardo, Ronaldo Nunes Toledo, Emerlinda Fausto Dijamco, Norman Cornelio De Asis, Angelica Kuizon, Elizabeth Catindig, Ronald Perez, Grace Aquitania, Jimrie David Pableo, Jay Karlou Sanchez, Ewa Czernecka, Aleksandra Cegiel, Dorota Knychas, Malgorzata Ochnio, Monika Kuligowska-Jakubowska, Marek Cesarz, Milena Kowalewska-Celejewska, Anna Masajtis‐Zagajewska, Łukasz Jankowski, Marcin Ojrzanowski, Magdalena Olszewska-Jander, Ewa Skokowska, Malgorzata Giermakowska-Samek, Elżbieta Luchowska, Renata Patkowska, Marzenna Sekulska, Dorota Marczuk-Krynicka, Andrzej Marciniak, Michal Barwijuk, Marcin Myślicki, Michał Siek, Danuta Wrońska, Jadwiga Tomsia-Goncerz, Krzysztof Wronski, Roman Junik, Szymon Dzialak, Ewelina Kurlapska, Wieslaw Malecha, Szymon Suwała, Patrícia Branco, Rita Birne, João Raposo, Marta Ferreira, Henrique Alexandrino, Helena Alves, Sara Fernandes Correia, Maria João Oliveira, Diogo Ramalho,
Summary Background Excess aldosterone accelerates chronic kidney disease progression. This phase 2 clinical trial assessed BI 690517, an aldosterone synthase inhibitor, for efficacy, safety, and dose selection. Methods This was a multinational, randomised, controlled, phase 2 trial. People aged 18 years or older with an estimated glomerular filtration rate (eGFR) of 30 to less than 90 mL/min/1·73 m 2 , a urine albumin to creatinine ratio (UACR) of 200 to less than 5000 mg/g, and serum potassium of 4·8 mmol/ ...
Elsevier BV