Produção Nacional
Revisado por pares
Hunaldo Lima de Menezes, Mário Jorge Júca, Edmundo Guilherme de Almeida Gomes, Benicio L.B.B.P. Nunes, Henrique Costa, Délcio Matos,
Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancerTo analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors.Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "Hospital São Paulo", ...
Tópico(s): Colorectal and Anal Carcinomas
2010 - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) | Arquivos de Gastroenterologia
Produção Nacional
Revisado por pares
Rosana Sueli da Motta Jafelice, César Guilherme de Almeida, João Frederico da Costa Azevedo Meyer, Heraldo L. Vasconcelos,
This paper proposes a model for the reoccupation of ants in a region of attraction, using evolutive partial differential diffusion–advection equations, in which the population dispersion and velocity in directions x and y are fuzzy parameters. The domain under study contains an attractive region, representing areas with high concentrations of palatable host plants with better nutritious qualities. The algorithm developed here uses information about the foraging behavior of a leaf-cutting ant colony ...
Tópico(s): Animal Behavior and Reproduction
2011 - Elsevier BV | Nonlinear Analysis Real World Applications
Produção Nacional
Revisado por pares
Guilherme de Almeida Santos, Caroline Pinto Coutinho, Matheus Matta Machado Mafra Duque E Meyer, Diego Vieira Sampaio, Geraldo Magela Gomes da Cruz,
The analysis of 2,840 cases of hemorrhoidectomy by open techniques of Milligan-Morgan (2,189 cases), Ferguson (341 cases) and mixed (310 cases) in 11,043 patients with hemorrhoidal disease (HD) allowed the following conclusions. The patients' acceptance of surgical indication for hemorrhoidectomy was 25.7%. Hemorrhoidectomy was more common among women (53.8%) than men (46.2%), and more accepted by women (26.5%) than men (24.8%). Hemorrhoidectomy was more common in patients of the fourth (27.7%), fifth (21. ...
Tópico(s): Pelvic floor disorders treatments
2012 - Thieme Medical Publishers (Germany) | Journal of Coloproctology
Produção Nacional
Revisado por pares
Guilherme de Almeida Souza Tedrus, Rita de Cássia Salvucci Celeste Ormenese, Sandra Maria SPERANZA, Yoon K. Chang, Fernando Martínez Bustos,
Farinhas de arroz e de aveia e amido de trigo foram adicionados de vital glúten e avaliados pelo Teste de Panificação. Usou-se como padrão uma amostra de farinha de trigo com características adequadas para produção de pão. Os níveis de adição de vital glúten foram de 10, 15, 17,5, 20 e 30% para a farinha de arroz e de 10, 20 e 30% para a farinha de aveia. Ao amido de trigo, extraído da farinha de trigo utilizada como padrão, foi adicionado vital glúten de forma a reconstituir o teor de glúten original ...
Tópico(s): Agricultural and Food Sciences
2001 - Sociedade Brasileira de Ciência e Tecnologia de Alimentos | Food Science and Technology
Irina S. Moreira, Panagiotis I. Koukos, Rita Melo, José Guilherme de Almeida, António J. Preto, Jörg Schaarschmidt, Mikaël Trellet, Zeynep H. Gümüş, Joaquim Pinto da Costa, Alexandre M. J. J. Bonvin,
We present SpotOn, a web server to identify and classify interfacial residues as Hot-Spots (HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated accuracy of 0.95 and sensitivity of 0.98 on an independent test set. The predictor was developed using an ensemble machine learning approach with up-sampling of the minor class. It was trained on 53 complexes using various features, based on both protein 3D structure and sequence. The SpotOn web interface is freely available at: ...
Tópico(s): RNA and protein synthesis mechanisms
2017 - Nature Portfolio | Scientific Reports
José Guilherme de Almeida, António J. Preto, Panagiotis I. Koukos, Alexandre M. J. J. Bonvin, Irina S. Moreira,
Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental ...
Tópico(s): Lipid Membrane Structure and Behavior
2017 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Biomembranes
Agostinho Lemos, Rita Melo, António J. Preto, José Guilherme de Almeida, Irina S. Moreira, M. Natália D. S. Cordeiro,
Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly affects the motor system. The causes are still unknown, and even though currently there is no cure, several therapeutic options are available to manage its symptoms. The development of novel antiparkinsonian agents and an understanding of their proper and optimal use are, indeed, highly demanding. For the last decades, L-3,4-DihydrOxyPhenylAlanine or levodopa (L-DOPA) has been the gold-standard therapy for the symptomatic ...
Tópico(s): Chemical Synthesis and Analysis
2018 - Bentham Science Publishers | Current Neuropharmacology
Jun Ma, Ronald Xie, Shamini Ayyadhury, Cheng Ge, Anubha Gupta, Ritu Gupta, Song Gu, Yao Zhang, Gihun Lee, Joonkee Kim, Wei Lou, Haofeng Li, Eric Upschulte, Timo Dickscheid, José Guilherme de Almeida, Yixin Wang, Lin Han, Xin Yang, Marco Labagnara, Vojislav Gligorovski, Maxime Scheder, Sahand Jamal Rahi, Carly Kempster, Alice Y. Pollitt, Léon Espinosa, Tâm Mignot, Jan Moritz Middeke, Jan‐Niklas Eckardt, Wangkai Li, Zhaoyang Li, Xiaochen Cai, Bizhe Bai, Noah F. Greenwald, David Van Valen, Erin Weisbart, Beth A. Cimini, T. Cheung, Oscar Brück, Gary D. Bader, Bo Wang,
Tópico(s): Advanced Neural Network Applications
2024 - Nature Portfolio | Nature Methods
Margarete A. Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, M. S. Vijayabaskar, E. Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J. Campbell, Eoin McKinney, Francesco Cucca, Moritz Gerstung, George S. Vassiliou,
Abstract Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis 1–4 . The understanding of how and when clonal haematopoiesis develops, the factors that govern its behaviour, how it interacts with ageing and how these variables relate to malignant progression remains limited 5,6 . Here we track 697 clonal haematopoiesis clones from 385 individuals 55 years of age or older ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2022 - Nature Portfolio | Nature
Produção Nacional
Revisado por pares
Sidney de Almeida Ferreira, Gregório Guilherme Almeida, Soraia de Oliveira Silva, Gabriela Peixoto Vogas, Ricardo Toshio Fujiwara, Antero Silva Ribeiro de Andrade, Maria Norma Melo,
Background The aim of this study was to evaluate the potential use of nasal, oral, and ear swabs for molecular diagnosis of canine visceral leishmaniasis (CVL) in an endemic urban area in Brazil. Methodology/Principal Findings Sixty-two naturally infected and ten healthy dogs were enrolled in this study. Bone marrow aspirates, peripheral blood, skin biopsy, and conjunctival, nasal, oral, and ear swabs were collected. All samples, except blood, were submitted to conventional PCR (cPCR) and quantitative ...
Tópico(s): T-cell and Retrovirus Studies
2013 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Flávia Caselli Pacheco, Giovanny Vinícius Araújo de França, Guilherme Almeida Elidio, César de Oliveira, Dirce Guilhem,
In September 2016, the Pan-American Health Organization (PAHO) declared the Region of the Americas free of measles (Pan American Health Organization/World Health Organization, 2016Pan American Health Organization/World Health Organization Washington, D.C., USA55th directing council. 68th session of the regional committee of who for the Americas — plan of action for maintaining measles, rubella, and congenital rubella syndrome elimination in the region of the Americas: final report2016.55th directing ...
Tópico(s): Immune responses and vaccinations
2019 - Elsevier BV | International Journal of Infectious Diseases
Produção Nacional
Revisado por pares
V. Costa, Guilherme Bicalho Civinelli de Almeida, Eveline Montessi Nicolini, Guilherme de Abreu Rodrigues, Bruna Malaquias Arguelles da Costa, Guilherme Heluey Carvalho, Álvaro Luiz Segregio dos Reis, Davi Pinto Colen,
COVID-19 infection may predispose to venous and arterial thromboembolism due to excessive inflammation, hypoxia, immobilization and disseminated intravascular coagulation; however, there are few reports of lower limb ischemia as the main manifestation of the disease. Male patient, 69 years old, asthmatic, ex-smoker and bearer of systemic arterial hypertension, has been admitted to the emergency department with sudden onset of pain in the right lower limb (RLL), associated with cyanosis and reduced ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2020 - Elsevier BV | International Journal of Surgery Case Reports
Produção Nacional
Revisado por pares
Levi Carina Terribile, Darlan Tavares Feitosa, Matheus Godoy Pires, Paula Carolina Rodrigues de Almeida, Guilherme de Oliveira, José Alexandre Felizola Diniz‐Filho, Nelson Jorge da Silva,
South American coralsnakes are characterized by inconspicuous and poorly known species, which are potentially very sensitive to climate change. Here, we assess the impact of future climate change on the distributions of the Micrurus lemniscatus species complex after addressing the Wallacean shortfalls and refining the knowledge about their current geographic distributions. We also evaluate the efficiency of the current reserve network to protect the species in the present and future. We applied ...
Tópico(s): Amphibian and Reptile Biology
2018 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Michelle Alonso Cassis, Renato Rodrigues de Almeida, Guilherme Janson, Renata Rodrigues de Almeida‐Pedrin, Márcio Rodrigues de Almeida,
Introduction The aim of this prospective clinical study was to investigate the cephalometric changes produced by bonded spurs associated with high-pull chincup therapy in children with Angle Class I malocclusion and anterior open bite. Methods Thirty patients with an initial mean age of 8.14 years and a mean anterior open bite of −3.93 mm were treated with bonded spurs associated with chincup therapy for 12 months. An untreated control group of 30 subjects with an initial mean age of 8.36 years and a mean anterior ...
Tópico(s): Cleft Lip and Palate Research
2012 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Guilherme Almeida, Rita de Cássia Siqueira-Soares, Thatiane Rodrigues Mota, Dyoni Matias de Oliveira, Josielle Abrahão, Marcela de Paiva Foletto-Felipe, Wanderley Dantas dos Santos, Osvaldo Ferrarese‐Filho, Rogério Marchiosi,
Aluminum oxide (Al2O3) nanoparticles (NPs) are among the nanoparticles most used industrially, but their impacts on living organisms are widely unknown. We evaluated the effects of 50–1000 mg L−1 Al2O3 NPs on the growth, metabolism of lignin and its monomeric composition in soybean plants. Al2O3 NPs did not affect the length of roots and stems. However, at the microscopic level, Al2O3 NPs altered the root surface inducing the formation of cracks near to root apexes and damage to the root cap. The ...
Tópico(s): Silicon Effects in Agriculture
2020 - Elsevier BV | Plant Physiology and Biochemistry
Produção Nacional
Revisado por pares
Edmundo Guilherme de Almeida Gomes, Mário Jorge Júca, Hunaldo Lima de Menezes, Benício Luiz Bulhões Barros Paula Nunes, Henrique Costa, Flávio de Oliveira Lima, Délcio Matos,
PURPOSE: To analyze the expression of metalloproteinase-1, metalloproteinase-7 and vascular endothelial growth factor (VEGF) in colorectal adenocarcinoma, and to correlate these with the clinical-pathological prognostic factors. METHODS: Tumor tissue from 82 patients was fixed in formalin and embedded in paraffin blocks. These samples were analyzed by means of the streptavidin-biotin immunohistochemical method, using the tissue microarray technique. Marker positivity was evaluated using categorical ...
Tópico(s): Cancer, Lipids, and Metabolism
2009 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Rita Melo, Agostinho Lemos, António J. Preto, José Guilherme de Almeida, João D. G. Correia, Özge Şensoy, Irina S. Moreira,
Cancer has become one of the main leading causes of morbidity and mortality worldwide. One of the critical drawbacks of current cancer therapeutics has been the lack of the target-selectivity, as these drugs should have an effect exclusively on cancer cells while not perturbing healthy ones. In addition, their mechanism of action should be sufficiently fast to avoid the invasion of neighbouring healthy tissues by cancer cells. The use of conventional chemotherapeutic agents and other traditional ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2018 - Bentham Science Publishers | Current Topics in Medicinal Chemistry
António J. Preto, Carlos A.V. Barreto, Salete J. Baptista, José Guilherme de Almeida, Agostinho Lemos, André Melo, M. Natália D. S. Cordeiro, Zeynep Kurkcuoglu, Rita Melo, Irina S. Moreira,
G-Protein coupled receptors (GPCRs) are involved in a myriad of pathways key for human physiology through the formation of complexes with intracellular partners such as G-proteins and arrestins (Arrs). However, the structural and dynamical determinants of these complexes are still largely unknown. Herein, we developed a computational big-data pipeline that enables the structural characterization of GPCR complexes with no available structure. This pipeline was used to study a well-known group of catecholamine ...
Tópico(s): Neuropeptides and Animal Physiology
2020 - American Chemical Society | Journal of Chemical Information and Modeling
Produção Nacional
Revisado por pares
Giancarlo Lucchetti, Luiz Guilherme Camargo de Almeida, Alessandra Lamas Granero Lucchetti,
INTRODUÇÃO: Os trabalhos que tratam da relação entre espiritualidade e saúde têm se disseminado pelas publicações internacionais, mostrando associações entre menores níveis de depressão e ansiedade, melhor qualidade de vida, menor número de internações e mortalidade. OBJETIVOS: Avaliar a relação da espiritualidade, religiosidade e saúde em pacientes em diálise. MÉTODOS: Por meio de consulta nos bancos do SciELO, LILACS, Medline e PsycINFO foi feita revisão de literatura. Foram selecionados e discutidos ...
Tópico(s): Religion and Society in Latin America
2010 - Sociedade Brasileira de Nefrologia | Brazilian Journal of Nephrology
Produção Nacional
Giancarlo Lucchetti, Luiz Guilherme Camargo de Almeida, Alessandra Lamas Granero Lucchetti,
Abstract Patients with chronic kidney disease often use religion as a coping strategy to relieve suffering and serve as a source of strength. The aim of this study was to identify religious aspects associated with mental health and quality of life in B razilian dialysis patients. A cross‐sectional study was performed involving two dialysis centers in B razil. Patients were selected consecutively over three typical dialysis treatment days. The questionnaire was self‐administered and covered the following ...
Tópico(s): Religion and Society in Latin America
2011 - Wiley | Hemodialysis International
Produção Nacional
Revisado por pares
Flávio Guilherme Vaz de Almeida Filho, Stéphane Calmant, F. Seyler, Guillaume Ramillien, Denizar Blitzkow, Ana Cristina Cancoro Matos, Joecila Santos Silva,
Gravity Recovery and Climate Experiment (GRACE) mission is dedicated to measuring temporal variations of the Earth's gravity field. In this study, the Stokes coefficients made available by Groupe de Recherche en Géodésie Spatiale (GRGS) at a 10-day interval were converted into equivalent water height (EWH) for a ~4-year period in the Amazon basin (from July-2002 to May-2006). The seasonal amplitudes of EWH signal are the largest on the surface of Earth and reach ~ 1250mm at that basin's center. Error budget ...
Tópico(s): Geomagnetism and Paleomagnetism Studies
2011 - INSTITUTO NACIONAL DE PESQUISAS DA AMAZÔNIA | Acta Amazonica
Produção Nacional
Revisado por pares
João César Guimarães Henriques, Alfredo Júlio Fernandes Neto, Guilherme de Araújo Almeida, Naila Aparecida de Godoi Machado, Éverton Ribeiro Lélis,
The magnitude of occasional discrepancies between the centric relation and maximal intercuspation positions remains a controversial subject. This study quantitatively evaluated the possible discrepancies in the condyle/mandibular fossa relationship between these positions using cone-beam computed tomography. Twenty young and asymptomatic volunteers were distributed equally into normal occlusion and Angle Class I, II and III malocclusion groups. They were submitted to one tomographic scan in maximal ...
Tópico(s): Facial Nerve Paralysis Treatment and Research
2011 - Brazilian Society of Dental Research | Brazilian Oral Research
Irene Hanning, Ashley R. Clement, C.M. Owens, Si Hong Park, Sean Pendleton, E.E. Scott, Guilherme Resende de Almeida, F. Gil, Steven C. Ricke,
Pasture-flock-raised poultry are becoming an increasingly popular product, but only limited options are currently available for maintaining gut health. For these producers, prebiotics are an attractive option because they are generally recognized as safe (GRAS) and can be mixed into the feed and thus do not require adjustments to production protocols. However, if prebiotic treatments reduce production performance, they would not be useful to producers. Thus, the objective of this study was to measure ...
Tópico(s): Moringa oleifera research and applications
2012 - Elsevier BV | Poultry Science
Produção Nacional
Revisado por pares
O artigo discute de forma exploratória a emergência de uma nova categoria identitária no Brasil, a de 'homem trans'. Essa se constrói diferenciando-se da identidade lésbica e, também, de expressões de gênero de outros grupos que tiveram seus corpos assignados como femininos ao nascimento, mas que contestam essa assignação sem, contudo, se afirmarem 'homens' de forma constante. Afirma-se que a emergência dos 'homens trans' tem sido potencializada pelo estabelecimento do processo transexualizador no ...
Tópico(s): Youth, Politics, and Society
2012 - UNIVERSIDADE FEDERAL DE SANTA CATARINA | Revista Estudos Feministas
Produção Nacional
Revisado por pares
Karine Evangelista, José Valladares‐Neto, Guilherme de Araújo Almeida,
OBJECTIVE: This study aimed to establish cephalometric reference values for mandibular symphysis in adults. Dentoalveolar, skeletal and soft tissue variables were measured considering the influence of gender and facial type. METHODS: The sample consisted of sixty cephalometric radiographs of white Brazilian adult patients, with a mean age of 27 years and 6 months, who had not undergone orthodontic treatment and who presented well-balanced faces and normal occlusion. The sample was standardized according ...
Tópico(s): Dental Radiography and Imaging
2012 - Dental Press Editora | Dental Press Journal of Orthodontics
Newton Kara José, Silvana Artioli Schellini, Maria Rosa Bet de Moraes Silva, Lígia Fernanda Bruni, Antonio Guilherme C. de Almeida,
Tópico(s): Environmental Sustainability and Education
1996 - Conselho Brasileiro de Oftalmologia | Arquivos Brasileiros de Oftalmologia
Produção Nacional
Revisado por pares
José Valladares‐Neto, Lucía Cevidanes, Wesley Cabral Rocha, Guilherme de Araújo Almeida, João Batista de Paiva, José Rino‐Neto,
In order to understand the conflicting information on temporomandibular joint (TMJ) pathophysiologic responses after mandibular advancement surgery, an overview of the literature was proposed with a focus on certain risk factors.A literature search was carried out in the Cochrane, PubMed, Scopus and Web of Science databases in the period from January 1980 through March 2013. Various combinations of keywords related to TMJ changes [disc displacement, arthralgia, condylar resorption (CR)] and aspects ...
Tópico(s): Oropharyngeal Anatomy and Pathologies
2014 - UNIVERSIDADE DE SÃO PAULO | Journal of Applied Oral Science
Produção Nacional
Revisado por pares
Éverton Ribeiro Lélis, João César Guimarães Henriques, Marcelo Tavares, Marcos Rogério de Mendonça, Alfredo Júlio Fernandes Neto, Guilherme de Araújo Almeida,
Studies of the condyle-mandibular fossa relationship are common, although the role of this relationship in the development of a temporomandibular disorder remains controversial.The purpose of this study was to quantitatively evaluate the condyle-mandibular fossa relationship in young individuals with intact dentitions and compare it to that between individuals with and without symptoms of temporomandibular disorder.Volunteers were classified as asymptomatic (n=20) or symptomatic (n=20) according to ...
Tópico(s): Dental Radiography and Imaging
2015 - Elsevier BV | Journal of Prosthetic Dentistry
Produção Nacional
Revisado por pares
Daniel Pereira, Olívia Meira Dias, Guilherme Eler de Almeida, Mariana Sponholz Araújo, Letícia Kawano-Dourado, Bruno Guedes Baldi, Ronaldo Adib Kairalla, Carlos Roberto Ribeiro de Carvalho,
To describe the characteristics of a cohort of patients with lung-dominant connective tissue disease (LD-CTD).This was a retrospective study of patients with interstitial lung disease (ILD), positive antinuclear antibody (ANA) results (≥ 1/320), with or without specific autoantibodies, and at least one clinical feature suggestive of connective tissue disease (CTD).Of the 1,998 patients screened, 52 initially met the criteria for a diagnosis of LD-CTD: 37% were male; the mean age at diagnosis was 56 years; ...
Tópico(s): Chronic Obstructive Pulmonary Disease (COPD) Research
2015 - Sociedade Brasileira de Pneumologia e Tisiologia | Jornal Brasileiro de Pneumologia
Produção Nacional
Revisado por pares
Larissa Kattiney OLIVEIRA, Guilherme de Araújo Almeida, Éverton Ribeiro Lélis, Marcelo Tavares, Alfredo Júlio Fernandes Neto,
To evaluate the association between temporomandibular disorder (TMD) and anxiety, quality of sleep, and quality of life in nursing professionals at theHospital de Clínicas de Uberlândia of theUniversidade Federal de Uberlândia – HCU-UFU (Medical University Hospital of the Federal University of Uberlândia), four questionnaires were given to nursing professionals. The questionnaires were completed by 160 of these professionals. The Fonseca's questionnaire was used to evaluate the presence and severity ...
Tópico(s): Occupational Health and Burnout
2015 - Brazilian Society of Dental Research | Brazilian Oral Research