Jun Ma, Ronald Xie, Shamini Ayyadhury, Cheng Ge, Anubha Gupta, Ritu Gupta, Song Gu, Yao Zhang, Gihun Lee, Joonkee Kim, Wei Lou, Haofeng Li, Eric Upschulte, Timo Dickscheid, José Guilherme de Almeida, Yixin Wang, Lin Han, Xin Yang, Marco Labagnara, Vojislav Gligorovski, Maxime Scheder, Sahand Jamal Rahi, Carly Kempster, Alice Y. Pollitt, Léon Espinosa, Tâm Mignot, Jan Moritz Middeke, Jan‐Niklas Eckardt, Wangkai Li, Zhaoyang Li, Xiaochen Cai, Bizhe Bai, Noah F. Greenwald, David Van Valen, Erin Weisbart, Beth A. Cimini, T. Cheung, Oscar Brück, Gary D. Bader, Bo Wang,
Tópico(s): Advanced Neural Network Applications
2024 - Nature Portfolio | Nature Methods
Margarete A. Fabre, José Guilherme de Almeida, Edoardo Fiorillo, Emily Mitchell, Aristi Damaskou, Justyna Rak, Valeria Orrù, Michele Marongiu, Michael Spencer Chapman, M. S. Vijayabaskar, E. Joanna Baxter, Claire Hardy, Federico Abascal, Nicholas Williams, Jyoti Nangalia, Iñigo Martincorena, Peter J. Campbell, Eoin McKinney, Francesco Cucca, Moritz Gerstung, George S. Vassiliou,
Abstract Clonal expansions driven by somatic mutations become pervasive across human tissues with age, including in the haematopoietic system, where the phenomenon is termed clonal haematopoiesis 1–4 . The understanding of how and when clonal haematopoiesis develops, the factors that govern its behaviour, how it interacts with ageing and how these variables relate to malignant progression remains limited 5,6 . Here we track 697 clonal haematopoiesis clones from 385 individuals 55 years of age or older ...
Tópico(s): Hematopoietic Stem Cell Transplantation
2022 - Nature Portfolio | Nature
Agostinho Lemos, Rita Melo, António J. Preto, José Guilherme de Almeida, Irina S. Moreira, M. Natália D. S. Cordeiro,
Parkinson's Disease (PD) is a long-term neurodegenerative brain disorder that mainly affects the motor system. The causes are still unknown, and even though currently there is no cure, several therapeutic options are available to manage its symptoms. The development of novel antiparkinsonian agents and an understanding of their proper and optimal use are, indeed, highly demanding. For the last decades, L-3,4-DihydrOxyPhenylAlanine or levodopa (L-DOPA) has been the gold-standard therapy for the symptomatic ...
Tópico(s): Chemical Synthesis and Analysis
2018 - Bentham Science Publishers | Current Neuropharmacology
Irina S. Moreira, Panagiotis I. Koukos, Rita Melo, José Guilherme de Almeida, António J. Preto, Jörg Schaarschmidt, Mikaël Trellet, Zeynep H. Gümüş, Joaquim Pinto da Costa, Alexandre M. J. J. Bonvin,
We present SpotOn, a web server to identify and classify interfacial residues as Hot-Spots (HS) and Null-Spots (NS). SpotON implements a robust algorithm with a demonstrated accuracy of 0.95 and sensitivity of 0.98 on an independent test set. The predictor was developed using an ensemble machine learning approach with up-sampling of the minor class. It was trained on 53 complexes using various features, based on both protein 3D structure and sequence. The SpotOn web interface is freely available at: ...
Tópico(s): RNA and protein synthesis mechanisms
2017 - Nature Portfolio | Scientific Reports
José Guilherme de Almeida, António J. Preto, Panagiotis I. Koukos, Alexandre M. J. J. Bonvin, Irina S. Moreira,
Membrane proteins (MPs) play diverse and important functions in living organisms. They constitute 20% to 30% of the known bacterial, archaean and eukaryotic organisms' genomes. In humans, their importance is emphasized as they represent 50% of all known drug targets. Nevertheless, experimental determination of their three-dimensional (3D) structure has proven to be both time consuming and rather expensive, which has led to the development of computational algorithms to complement the available experimental ...
Tópico(s): Lipid Membrane Structure and Behavior
2017 - Elsevier BV | Biochimica et Biophysica Acta (BBA) - Biomembranes
Produção Nacional
Revisado por pares
Guilherme de Almeida Santos, Caroline Pinto Coutinho, Matheus Matta Machado Mafra Duque E Meyer, Diego Vieira Sampaio, Geraldo Magela Gomes da Cruz,
The analysis of 2,840 cases of hemorrhoidectomy by open techniques of Milligan-Morgan (2,189 cases), Ferguson (341 cases) and mixed (310 cases) in 11,043 patients with hemorrhoidal disease (HD) allowed the following conclusions. The patients' acceptance of surgical indication for hemorrhoidectomy was 25.7%. Hemorrhoidectomy was more common among women (53.8%) than men (46.2%), and more accepted by women (26.5%) than men (24.8%). Hemorrhoidectomy was more common in patients of the fourth (27.7%), fifth (21. ...
Tópico(s): Pelvic floor disorders treatments
2012 - Thieme Medical Publishers (Germany) | Journal of Coloproctology
Produção Nacional
Revisado por pares
Rosana Sueli da Motta Jafelice, César Guilherme de Almeida, João Frederico da Costa Azevedo Meyer, Heraldo L. Vasconcelos,
This paper proposes a model for the reoccupation of ants in a region of attraction, using evolutive partial differential diffusion–advection equations, in which the population dispersion and velocity in directions x and y are fuzzy parameters. The domain under study contains an attractive region, representing areas with high concentrations of palatable host plants with better nutritious qualities. The algorithm developed here uses information about the foraging behavior of a leaf-cutting ant colony ...
Tópico(s): Animal Behavior and Reproduction
2011 - Elsevier BV | Nonlinear Analysis Real World Applications
Produção Nacional
Revisado por pares
Hunaldo Lima de Menezes, Mário Jorge Júca, Edmundo Guilherme de Almeida Gomes, Benicio L.B.B.P. Nunes, Henrique Costa, Délcio Matos,
Search of tumors markers that allow treatment with higher survival rates, and indicate the response to treatment and recurrence of cancerTo analyze the immunoexpression of the proteins p53, bcl-2 and Ki-67 in colorectal adenocarcinoma and correlate them with the clinical-pathological prognostic factors.Tissue microarray paraffin blocks were made from colorectal adenocarcinoma tissue resected from 82 patients who had undergone surgery but not chemotherapy or radiotherapy, at "Hospital São Paulo", ...
Tópico(s): Colorectal and Anal Carcinomas
2010 - Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia (IBEPEGE) | Arquivos de Gastroenterologia
Produção Nacional
Revisado por pares
Guilherme de Almeida Souza Tedrus, Rita de Cássia Salvucci Celeste Ormenese, Sandra Maria SPERANZA, Yoon K. Chang, Fernando Martínez Bustos,
Farinhas de arroz e de aveia e amido de trigo foram adicionados de vital glúten e avaliados pelo Teste de Panificação. Usou-se como padrão uma amostra de farinha de trigo com características adequadas para produção de pão. Os níveis de adição de vital glúten foram de 10, 15, 17,5, 20 e 30% para a farinha de arroz e de 10, 20 e 30% para a farinha de aveia. Ao amido de trigo, extraído da farinha de trigo utilizada como padrão, foi adicionado vital glúten de forma a reconstituir o teor de glúten original ...
Tópico(s): Agricultural and Food Sciences
2001 - Sociedade Brasileira de Ciência e Tecnologia de Alimentos | Food Science and Technology
Produção Nacional
Revisado por pares
Sidney de Almeida Ferreira, Gregório Guilherme Almeida, Soraia de Oliveira Silva, Gabriela Peixoto Vogas, Ricardo Toshio Fujiwara, Antero Silva Ribeiro de Andrade, Maria Norma Melo,
Background The aim of this study was to evaluate the potential use of nasal, oral, and ear swabs for molecular diagnosis of canine visceral leishmaniasis (CVL) in an endemic urban area in Brazil. Methodology/Principal Findings Sixty-two naturally infected and ten healthy dogs were enrolled in this study. Bone marrow aspirates, peripheral blood, skin biopsy, and conjunctival, nasal, oral, and ear swabs were collected. All samples, except blood, were submitted to conventional PCR (cPCR) and quantitative ...
Tópico(s): T-cell and Retrovirus Studies
2013 - Public Library of Science | PLoS neglected tropical diseases
Produção Nacional
Revisado por pares
Flávia Caselli Pacheco, Giovanny Vinícius Araújo de França, Guilherme Almeida Elidio, César de Oliveira, Dirce Guilhem,
In September 2016, the Pan-American Health Organization (PAHO) declared the Region of the Americas free of measles (Pan American Health Organization/World Health Organization, 2016Pan American Health Organization/World Health Organization Washington, D.C., USA55th directing council. 68th session of the regional committee of who for the Americas — plan of action for maintaining measles, rubella, and congenital rubella syndrome elimination in the region of the Americas: final report2016.55th directing ...
Tópico(s): Immune responses and vaccinations
2019 - Elsevier BV | International Journal of Infectious Diseases
Produção Nacional
Revisado por pares
V. Costa, Guilherme Bicalho Civinelli de Almeida, Eveline Montessi Nicolini, Guilherme de Abreu Rodrigues, Bruna Malaquias Arguelles da Costa, Guilherme Heluey Carvalho, Álvaro Luiz Segregio dos Reis, Davi Pinto Colen,
COVID-19 infection may predispose to venous and arterial thromboembolism due to excessive inflammation, hypoxia, immobilization and disseminated intravascular coagulation; however, there are few reports of lower limb ischemia as the main manifestation of the disease. Male patient, 69 years old, asthmatic, ex-smoker and bearer of systemic arterial hypertension, has been admitted to the emergency department with sudden onset of pain in the right lower limb (RLL), associated with cyanosis and reduced ...
Tópico(s): Diabetic Foot Ulcer Assessment and Management
2020 - Elsevier BV | International Journal of Surgery Case Reports
Produção Nacional
Revisado por pares
Levi Carina Terribile, Darlan Tavares Feitosa, Matheus Godoy Pires, Paula Carolina Rodrigues de Almeida, Guilherme de Oliveira, José Alexandre Felizola Diniz‐Filho, Nelson Jorge da Silva,
South American coralsnakes are characterized by inconspicuous and poorly known species, which are potentially very sensitive to climate change. Here, we assess the impact of future climate change on the distributions of the Micrurus lemniscatus species complex after addressing the Wallacean shortfalls and refining the knowledge about their current geographic distributions. We also evaluate the efficiency of the current reserve network to protect the species in the present and future. We applied ...
Tópico(s): Amphibian and Reptile Biology
2018 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Michelle Alonso Cassis, Renato Rodrigues de Almeida, Guilherme Janson, Renata Rodrigues de Almeida‐Pedrin, Márcio Rodrigues de Almeida,
Introduction The aim of this prospective clinical study was to investigate the cephalometric changes produced by bonded spurs associated with high-pull chincup therapy in children with Angle Class I malocclusion and anterior open bite. Methods Thirty patients with an initial mean age of 8.14 years and a mean anterior open bite of −3.93 mm were treated with bonded spurs associated with chincup therapy for 12 months. An untreated control group of 30 subjects with an initial mean age of 8.36 years and a mean anterior ...
Tópico(s): Cleft Lip and Palate Research
2012 - Elsevier BV | American Journal of Orthodontics and Dentofacial Orthopedics
Produção Nacional
Revisado por pares
Guilherme Almeida, Rita de Cássia Siqueira-Soares, Thatiane Rodrigues Mota, Dyoni Matias de Oliveira, Josielle Abrahão, Marcela de Paiva Foletto-Felipe, Wanderley Dantas dos Santos, Osvaldo Ferrarese‐Filho, Rogério Marchiosi,
Aluminum oxide (Al2O3) nanoparticles (NPs) are among the nanoparticles most used industrially, but their impacts on living organisms are widely unknown. We evaluated the effects of 50–1000 mg L−1 Al2O3 NPs on the growth, metabolism of lignin and its monomeric composition in soybean plants. Al2O3 NPs did not affect the length of roots and stems. However, at the microscopic level, Al2O3 NPs altered the root surface inducing the formation of cracks near to root apexes and damage to the root cap. The ...
Tópico(s): Silicon Effects in Agriculture
2020 - Elsevier BV | Plant Physiology and Biochemistry
António J. Preto, Carlos A.V. Barreto, Salete J. Baptista, José Guilherme de Almeida, Agostinho Lemos, André Melo, M. Natália D. S. Cordeiro, Zeynep Kurkcuoglu, Rita Melo, Irina S. Moreira,
G-Protein coupled receptors (GPCRs) are involved in a myriad of pathways key for human physiology through the formation of complexes with intracellular partners such as G-proteins and arrestins (Arrs). However, the structural and dynamical determinants of these complexes are still largely unknown. Herein, we developed a computational big-data pipeline that enables the structural characterization of GPCR complexes with no available structure. This pipeline was used to study a well-known group of catecholamine ...
Tópico(s): Neuropeptides and Animal Physiology
2020 - American Chemical Society | Journal of Chemical Information and Modeling
Rita Melo, Agostinho Lemos, António J. Preto, José Guilherme de Almeida, João D. G. Correia, Özge Şensoy, Irina S. Moreira,
Cancer has become one of the main leading causes of morbidity and mortality worldwide. One of the critical drawbacks of current cancer therapeutics has been the lack of the target-selectivity, as these drugs should have an effect exclusively on cancer cells while not perturbing healthy ones. In addition, their mechanism of action should be sufficiently fast to avoid the invasion of neighbouring healthy tissues by cancer cells. The use of conventional chemotherapeutic agents and other traditional ...
Tópico(s): Radiopharmaceutical Chemistry and Applications
2018 - Bentham Science Publishers | Current Topics in Medicinal Chemistry
Produção Nacional
Revisado por pares
Edmundo Guilherme de Almeida Gomes, Mário Jorge Júca, Hunaldo Lima de Menezes, Benício Luiz Bulhões Barros Paula Nunes, Henrique Costa, Flávio de Oliveira Lima, Délcio Matos,
PURPOSE: To analyze the expression of metalloproteinase-1, metalloproteinase-7 and vascular endothelial growth factor (VEGF) in colorectal adenocarcinoma, and to correlate these with the clinical-pathological prognostic factors. METHODS: Tumor tissue from 82 patients was fixed in formalin and embedded in paraffin blocks. These samples were analyzed by means of the streptavidin-biotin immunohistochemical method, using the tissue microarray technique. Marker positivity was evaluated using categorical ...
Tópico(s): Cancer, Lipids, and Metabolism
2009 - Sociedade Brasileira Para o Desenvolvimento da Pesquisa em Cirurgia | Acta Cirúrgica Brasileira
Produção Nacional
Revisado por pares
Otávio Guilherme Gonçalves de Almeida, Elaine Cristina Pereira De Martinis,
Metagenomic studies about cocoa fermentation have mainly reported on the analysis of short reads for determination of operational taxonomic units. However, it is also important to determine metagenome-assembled genomes (MAGs), which are genomes deriving from the assembly of metagenomics. For this research, all the cocoa metagenomes from public databases were downloaded, resulting in five data sets: one from Ghana and four from Brazil. In addition, in silico approaches were used to describe putative ...
Tópico(s): Studies on Chitinases and Chitosanases
2021 - American Society for Microbiology | Applied and Environmental Microbiology
Produção Nacional
Revisado por pares
Giuseppe Loprencipe, Flávio Guilherme Vaz de Almeida Filho, Rafael Henrique de Oliveira, Salvatore Bruno,
Road networks are monitored to evaluate their decay level and the performances regarding ride comfort, vehicle rolling noise, fuel consumption, etc. In this study, a novel inertial sensor-based system is proposed using a low-cost inertial measurement unit (IMU) and a global positioning system (GPS) module, which are connected to a Raspberry Pi Zero W board and embedded inside a vehicle to indirectly monitor the road condition. To assess the level of pavement decay, the comfort index awz defined by ...
Tópico(s): Smart Materials for Construction
2021 - Multidisciplinary Digital Publishing Institute | Sensors
Produção Nacional
Revisado por pares
Orlando de Salvo, Maria Tereza Saraiva de Souza, Flávio Guilherme Vaz de Almeida Filho,
The consumption of fossil fuels by motor vehicles has increased greenhouse gas emissions in the atmosphere. The automotive industry has invested in environmental technologies to reduce these emissions. This study aimed to determine whether in light-duty vehicles deploying environmental technologies met the energy efficiency ratings of the Brazilian Vehicle Labelling Programme (BVLP) in 2013, 2015, and 2017. In 2013, Brazil implemented the ‘INOVAR-AUTO’ regulation to improve vehicle energy efficiency. ...
Tópico(s): Electric Vehicles and Infrastructure
2021 - Elsevier BV | Energy
Veronica Gatto, Renato L. Binati, Wilson Josè Fernandes Lemos, Arianna Basile, Laura Treu, Otávio Guilherme Gonçalves de Almeida, Giada Innocente, Stefano Campanaro, Sandra Torriani,
• Lachancea thermotolerans strains display a huge diversity in lactic acid production. • Whole-genome sequences of high and low lactic acid producer strains were obtained. • Sequences of key genes for lactic acid accumulation were aligned and scrutinised. • Differences in promoters and transcription factor binding sites were highlighted. • Gene expression analysis revealed dissimilarities in the transcription of the genes ldh . Non-conventional yeasts are increasingly applied in fermented beverage industry to obtain ...
Tópico(s): Fungal and yeast genetics research
2020 - Elsevier BV | Microbiological Research
Produção Nacional
Revisado por pares
Otávio Guilherme Gonçalves de Almeida, Uelinton Manoel Pinto, Claudia Matos, Diego Araújo Frazilio, Valeria Braga, Márcia Regina von Zeska Kress, Elaine Cristina Pereira De Martinis,
Cocoa fermentation is a spontaneous process shaped by a variable microbial ecosystem which is assembled due to cross-feeding relationship among yeasts and bacteria, resulting in a synchronized microbial succession started by yeasts, followed by lactic acid bacteria (LAB) and finalized by acetic acid bacteria (AAB). Several studies have indicated the effect of microbial interactions in food ecosystems highlighting the importance of quorum sensing (QS) in bacterial adaptation in harsh environments modulating ...
Tópico(s): Probiotics and Fermented Foods
2020 - Elsevier BV | Food Research International
Produção Nacional
Revisado por pares
Guilherme Armando de Almeida Pereira, Álvaro Veiga,
Tópico(s): Complex Systems and Time Series Analysis
2019 - Springer Science+Business Media | Water Resources Management
Produção Nacional
Revisado por pares
Orlando de Salvo, Flávio Guilherme Vaz de Almeida Filho,
Even with the automotive technological evolution steadily improving energy efficiency, the transportation sector continues to account for more than one-fifth of greenhouse gas emissions (GHG). The official fuel consumption information has presented divergences in relation to the values found in real driving. Due to this variation, the effectiveness of technologies for the improvement of energy efficiency has been questioned. Aiming to verify these divergences, the aim of this study was to evaluate ...
Tópico(s): Electric Vehicles and Infrastructure
2019 - Elsevier BV | Applied Energy
Produção Nacional
Revisado por pares
João Pedro Rueda Furlan, Otávio Guilherme Gonçalves de Almeida, Elaine Cristina Pereira De Martinis, Eliana Guedes Stehling,
Acinetobacter calcoaceticus-Acinetobacter baumannii complex is considered one of the main causes of hospital-acquired infections. Acinetobacter seifertii was recently characterized within this complex and it has been described as an emergent pathogen associated with bacteremia. The emergence of multidrug-resistant (MDR) bacteria, including Acinetobacter sp., is considered a global public health threat and an environmental problem because MDR bacteria have been spreading from several sources. Therefore, ...
Tópico(s): Pharmaceutical and Antibiotic Environmental Impacts
2019 - Frontiers Media | Frontiers in Microbiology
Produção Nacional
Revisado por pares
Otávio Guilherme Gonçalves de Almeida, Elaine Cristina Pereira De Martinis,
Tópico(s): Gut microbiota and health
2018 - Springer Science+Business Media | Applied Microbiology and Biotechnology
Produção Nacional
Revisado por pares
José Guilherme de Andrade Almeida, Eliana Lúcia Ferreira,
Resumo Esta pesquisa tem como objetivo discutir o processo de inclusão de alunos com deficiência na educação superior brasileira, com especial foco nos sentidos mobilizados por esta inclusão nos discursos ali circulantes. Com caráter exploratório-descritivo, nos valemos da Análise de Discurso na ótica francesa para explorar o processo de produção de sentidos nas estatísticas oficias sobre esta inclusão no Brasil e em uma instituição federal de educação superior, realizando ainda, entrevistas com ...
Tópico(s): Social and Political Issues
2018 - Associação Brasileira de Psicologia Escolar e Educacional | Psicologia Escolar e Educacional
Produção Nacional
Revisado por pares
Simone da Costa Mello, Francis J. Pierce, Rachel Tonhati, Guilherme Silva De Almeida, Durval Dourado Neto, Kiran Pavuluri,
Polyhalite (PH) is a hydrated sulfate evaporite mineral containing potassium, calcium, magnesium, and sulfur, nutrients all required in significant quantities by crops, but has limited evaluation as a fertilizer for potato ( Solanum tuberosum L.). Fertilizer source and application rate field trials were conducted to evaluate PH as a fertilizer for potato production in the weathered tropical soils in Brazil. We selected two locations in the potato producing region of Southeast Brazil in 2015–16, one ...
Tópico(s): Potato Plant Research
2018 - American Society for Horticultural Science | HortScience
Produção Nacional
Revisado por pares
Guilherme Armando de Almeida Pereira, Álvaro Veiga,
Tópico(s): Electric Power System Optimization
2017 - Springer Science+Business Media | Stochastic Environmental Research and Risk Assessment