Ángel Sevillano, Monserrat Diaz, Fernando Caravaca‐Fontán, Clara Barrios, Carmen Bernis, Jimena Cabrera, Jesús Calviño, L. Castillo, Carmen Cobelo, Patricia Delgado-Mallén, Mario Espinosa, Gema Fernández‐Juárez, María José Fernández‐Reyes, Rosa García-Osuna, Patricia García, Marián Goicoechea, Fayna González-Cabrera, Diomaris A. Guzmán, Manuel Heras, Guillermo Martín-Reyes, Alberto Martínez, Teresa Olea, Jessy Korina Peña, Luís F. Quintana, Cristina Rabasco, Katia López Revuelta, Lida Rodas, Nuria Rodríguez-Mendiola, Eva Rodríguez, Luz San Miguel, María Dolores Sánchez de la Nieta, Amir Shabaka, Milagros Sierra, Alfonso Valera, Mercedes Velo, Eduardo Verde, José Ballarín, Óscar Noboa, Juan Antonio Moreno, Eduardo Gutiérrez, Manuel Praga,
Some studies suggest that the incidence of IgA nephropathy is increasing in older adults, but there is a lack of information about the epidemiology and behavior of the disease in that age group.In this retrospective multicentric study, we analyzed the incidence, forms of presentation, clinical and histologic characteristics, treatments received, and outcomes in a cohort of 151 patients ≥65 years old with biopsy-proven IgA nephropathy diagnosed between 1990 and 2015. The main outcome was a composite ...
Tópico(s): Chronic Kidney Disease and Diabetes
2019 - Lippincott Williams & Wilkins | Clinical Journal of the American Society of Nephrology
Ángel Chimenea, Lutgardo García‐Díaz, Ana María Calderón, María Moreno-De las Heras, Guillermo Antiñolo,
Mirror syndrome (MS) is a rare obstetric condition usually defined as the development of maternal edema in association with fetal hydrops. The pathogenesis of MS remains unclear and may be misdiagnosed as pre-eclampsia. We report a case series of MS in which fetal therapy (intrauterine blood transfusion and pleuroamniotic shunt) resulted in fetal as well as maternal favourable course with complete resolution of the condition in both mother and fetus. Our case series add new evidence to support that ...
Tópico(s): Fetal and Pediatric Neurological Disorders
2018 - BioMed Central | BMC Pregnancy and Childbirth
J.C. Angulo, I. Arance, A. García-Tello, María Heras, Guillermo Andrés, H. Gimbernat, F. Lista, F. Ramón de Fata,
The utility of a virtual reality simulator for training of the photoselective vaporization of the prostate with diode laser was studied.Two experiments were performed with a simulator (VirtaMed AG, Zürich, Switzerland) with software for specific training in prostate vaporization in contact mode with Twister fiber (Biolitec AG, Jena, German). Eighteen surgeons performed ablation of the prostate (55 cc) twice and compared the score obtained (190 points efficacy and 80 safety) in the second one of them ...
Tópico(s): Prostate Cancer Diagnosis and Treatment
2014 - Elsevier BV | Actas Urológicas Españolas
María Carmen Cénit, Antonio Alcina, Ana Márquez, Juan L. Mendoza, M Díaz-Rubio, V. De Las Heras, Guillermo Izquierdo, Rosa Arroyo-García, Óscar Fernández, Emilio G. de la Concha, Fuencisla Matesanz, Elena Urcelay,
Tópico(s): Whipple's Disease and Interleukins
2010 - Springer Nature | Genes and Immunity
Isidoro Segura-Heras, Guillermo Escrivá-Escrivà, Manuel Alcázar-Ortega,
The importance of renewable energy increases in activities relating to new forms of managing and operating electrical power: especially wind power. Wind generation is increasing its share in the electricity generation portfolios of many countries. Wind power production in Spain has doubled over the past four years and has reached 20 GW. One of the greatest problems facing wind farms is that the electrical power generated depends on the variable characteristics of the wind. To become competitive ...
Tópico(s): Power System Reliability and Maintenance
2010 - Elsevier BV | Renewable Energy
J.C. Angulo, I. Arance, A. García-Tello, María Heras, Guillermo Andrés, H. Gimbernat, F. Lista, F. Ramón de Fata,
The utility of a virtual reality simulator for training of the photoselective vaporization of the prostate with diode laser was studied. Two experiments were performed with a simulator (VirtaMed AG, Zürich, Switzerland) with software for specific training in prostate vaporization in contact mode with Twister fiber (Biolitec AG, Jena, German). Eighteen surgeons performed ablation of the prostate (55 cc) twice and compared the score obtained (190 points efficacy and 80 safety) in the second one of them ...
Tópico(s): Pelvic floor disorders treatments
2014 - Elsevier BV | Actas Urológicas Españolas (English Edition)
Glen Douglass, Alexander Arriola, I. Heras, Guillermo Martín, E. Le Coarer, Simon Gross, Michael J. Withford,
With the growing complexity of astronomical instruments devoted to interferometry, such as MATISSE (a 4 telescope beam combiner) or FIRST (a 9 sub-apertures beam combiner), and the rebirth of space projects such as LIFE (a mid-infrared interferometer), integrated optics devices can be an interesting and complementary approach for beam combination of a large number of apertures. Moreover, one of the approaches for beam combination is pairwise combination of the inputs (either from individual telescopes ...
Tópico(s): Optical Coatings and Gratings
2018 - Optica Publishing Group | Optics Express
Esteban Fernández Sánchez, José María de las Heras Montes, Guillermo O. Perez Bustamante, Camilo J. Vázquez,
Technological knowledge imitation is increasingly becoming a competitive behaviour, which allows firms to be at the cutting edge of technological development. Despite the growth of external knowledge acquisition as part of competitive intelligence efforts, technological imitators have to face up to the difficulties built up by innovators in order to protect their competitive knowledge. To overcome imitation barriers, firms need to have a correct understanding of the technological knowledge sources ...
Tópico(s): Intellectual Capital and Performance Analysis
1999 - Inderscience Publishers | International Journal of Technology Management
... 978-3-031-04729-9_1Héctor A. Echavarria-Heras, Cecilia Leal-Ramírez, Guillermo Gómez, Elia Montiel-Arzate, Jorge-Antonio Lopez-Renteria ...
Tópico(s): Insect symbiosis and bacterial influences
1927 - University of Chicago Press | The Quarterly Review of Biology
José A. Heras, Guillermo Fernández‐Anaya,
Two results support the idea that the scalar and vector potentials in the Lorenz gauge can be considered to be physical quantities: (i) they separately satisfy the properties of causality and propagation at the speed of light and not imply spurious terms and (ii) they can naturally be written in a manifestly covariant form.In this paper we introduce expressions for the Lorenzgauge potentials at the present time in terms of electric and magnetic fields at the retarded time.These expressions provide ...
Tópico(s): Quantum and Classical Electrodynamics
2010 - IOP Publishing | European Journal of Physics
Irina Heras, Armando Alvis, Guillermo Arrázola,
ResumenEl objetivo de esta investigación fue optimizar el proceso de extracción de antocianinas obtenidas de berenjena (Solanum melongena L.) y evaluar su capacidad antioxidante.A extractos de piel y pulpa se le realizaron análisis fisicoquímicos, contenido en fenoles y antocianos.Para la optimización del proceso de extracción de las antocianinas se empleó la metodología de superficie de respuesta con tres factores: concentración de solvente etanol acidificado 1% ácido ortofosfórico (50 a 90% v/v), ...
Tópico(s): Essential Oils and Antimicrobial Activity
2013 - Centro de Informacion Tecnologica | Información tecnológica
Martín Pérez‐Andres, Júlia Almeida, M Martín-Ayuso, Natalia de las Heras, Marı́a Jesús Moro, Guillermo Martín–Núñez, Josefina Galende, Rebeca Cuello, Isabel Abuín, Inmaculada Moreno, Mercedes Domínguez, José‐Ángel Hernández‐Rivas, Gema Mateo, Jesús F. San Miguel, Alberto Órfão,
Abstract Clonal plasma cells (PC) from different types of monoclonal gammopathies (MG) display distinct phenotypes consistent with an increased antigen‐presentation and T‐cell costimulation in MG of undetermined significance that deteriorates in malignant conditions. Expression of other cell surface and soluble molecules ( e.g . adhesion/proliferation molecules) involved in the interaction between clonal PC and the bone marrow (BM) microenvironment has also been related to malignant PC, although the exact ...
Tópico(s): Chemokine receptors and signaling
2008 - Wiley | International Journal of Cancer
Mariano García‐Yuste, José María Matilla, T. Alvarez-Gago, J.L. Duque, F. Heras, L.J. Cerezal, Guillermo Ramos,
Tópico(s): Neuroblastoma Research and Treatments
2000 - Elsevier BV | The Annals of Thoracic Surgery
Alfonso Durán Heras, Isabel García, Guillermo Castilla Alcalá,
Approaches to space-related problems that model decision-making and interactions at the level of individuals, and thus require disaggregated population data (i.e. specifying all attributes for each individual) are increasingly being used in various research domains. Actual population data is generally unavailable due to confidentiality and cost constraints. Therefore, synthetic population generation techniques based on aggregated marginal constraints and a random sample are often used. The two sample- ...
Tópico(s): Insurance, Mortality, Demography, Risk Management
2017 - Elsevier BV | Computers Environment and Urban Systems
Marcos Sebastián Dreon, Guillermo Schinella, Horacio Heras, Ricardo J. Pollero,
Tópico(s): Mollusks and Parasites Studies
2003 - Elsevier BV | Archives of Biochemistry and Biophysics
Odalys Rivera Fernández, C Arnal-Garcia, Rafael Arroyo-González, Luís Brieva, M.C. Calles-Hernández, B Casanova-Estruch, Manuel Comabella, Velasco Heras, Jose Ángel García-Merino, Hernández-Pérez, Guillermo Izquierdo, Elisabet Matas, José Meca-Lallana, M.M. Mendibe-Bilbao, Daniel Muñoz‐García, Javier Olascoaga, Celia Oreja‐Guevara, J.M. Prieto, L. Ramió-Torrentà, Alfredo Rodríguez Antigüedad, Albert Saiz, N. Téllez, Larissa Villar, Mar Tintoré,
The most significant data presented at the 28th Congress of the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), held in France in October 2012, have been summarised in the fifth edition of the Post-ECTRIMS Experts Meeting, held in Madrid in October 2012. This led to the drafting of this review, which has been published in three parts. This third part of the Post-ECTRIMS review presents the findings from the latest studies conducted with disease-modifying treatments, ...
Tópico(s): Immunotherapy and Immune Responses
2011 - Viguera Publishers | Revista de Neurología
Carlos S. Torres Inga, Cristina Velasco-Heras, A. Aguirre, Guillermo Guevara-Viera, Raúl Guevara-Viera,
Ecuador’s credit unions or COACs play a key role inside the local economy, and the pandemic period has shown the weakness of the entities. Understanding the efficiency of the country’s largest COACs and the different factors related to it can provide important information for policymakers and the sector in general. Therefore, our main goal was the evaluation of technical efficiency and the factors that influenced it during the years from 2009 to 2020 which included the pandemic period. For this, ...
Tópico(s): Working Capital and Financial Performance
2022 - Multidisciplinary Digital Publishing Institute | Economies
Miguel Martín, Noelia Martínez-Jáñez, Manuel Ramos, Lourdes Calvo, Aña Lluch, Pilar Zamora, Montserrat Muñoz, Eva Carrasco, Rosalía Caballero, José A. García‐Sáenz, Eva Guerra, Daniela Caronia, Antonio Casado, Manuel Ruíz‐Borrego, Blanca Hernando, José Ignacio Chacón, Julio César de la Torre Montero, María Ángeles Jimeno, L. Heras, Rosario Alonso, Juan de la Haba-Rodríguez, Guillermo Pita, Manuel Constenla, Anna González‐Neira,
Abstract Author Summary Background. The approved capecitabine regimen as monotherapy in metastatic breast cancer (MBC) is 1,250 mg/m2 twice daily for 2 weeks on and 1 week off (Cint). Dose modifications are often required because of severe hand-foot syndrome (HFS). We tested a continuous regimen with a lower daily dose but a similar cumulative dose in an attempt to reduce the severity of adverse events (AEs) while maintaining efficacy. Methods. We randomized 195 patients with HER-2/neu-negative MBC ...
Tópico(s): Multiple Myeloma Research and Treatments
2015 - AlphaMed Press | The Oncologist
Yuri Álvarez, María García-Fernández, Guillermo Álvarez-Narciandi, Fernando Las‐Heras,
Advances in unmanned aerial vehicle (UAV) technology have fostered its use in a wide range of areas, such as agriculture and forestry, surveillance and security, and infrastructure inspection. One of the advantages of UAVs is their ability to conduct remote inspection and sensing by placing different kinds of sensors on board them. In this sense, UAV-based ground-penetrating radar (GPR) systems are of particular interest as they bring together the advantages of UAVs and GPR, resulting in contactless ...
Tópico(s): Indoor and Outdoor Localization Technologies
2022 - Institute of Electrical and Electronics Engineers | IEEE Geoscience and Remote Sensing Magazine
María García-Fernández, Yuri Álvarez, Alessandro De Mitri, David Castrillo Martínez, Guillermo Álvarez-Narciandi, Fernando Las‐Heras,
In recent years, Unmanned Aerial Vehicles (UAV)-based Ground Penetrating Radar (GPR) systems have been developed due to their advantages for safe and fast detection of Improvised Explosive Devices (IEDs) and landmines. The complexity of these systems requires performing extensive measurement campaigns in order to test their performance and detection capabilities. However, UAV flights are limited by weather conditions and battery autonomy. To overcome these problems, this contribution presents a portable ...
Tópico(s): Indoor and Outdoor Localization Technologies
2020 - Multidisciplinary Digital Publishing Institute | Remote Sensing
A. Llorente-Alonso, J. Peña-Poza, Guillermo de Arcas, Manuel García Heras, Juan Manuel López, María Ángeles Villegas Broncano,
Environmental acidity is a key parameter in Cultural Heritage conservation issues since it has a direct impact on degradation of both exposed and stored materials. Unfortunately, most of the acidity sensors now available are electrodes, which are not able to measure pH in gaseous phases and, therefore, are not suitable for measuring the environmental acidity of the air. This paper describes the development of an interface electronic system designed for the practical application and using of environmental ...
Tópico(s): Gas Sensing Nanomaterials and Sensors
2013 - Elsevier BV | Sensors and Actuators A Physical
Manuel Alcázar-Ortega, Guillermo Escrivá-Escrivà, Isidoro Segura-Heras,
The authors present a methodology, which is demonstrated with some applications to the commercial sector, in order to validate a Demand Response (DR) evaluation method previously developed and applied to a wide range of industrial and commercial segments, whose flexibility was evaluated by modeling. DR is playing a more and more important role in the framework of electricity systems management for the effective integration of other distributed energy resources. Consequently, customers must identify ...
Tópico(s): Building Energy and Comfort Optimization
2010 - Elsevier BV | Energy Conversion and Management
Guillermo Escrivá-Escrivà, Isidoro Segura-Heras, Manuel Alcázar-Ortega,
Tópico(s): Energy Efficiency and Management
2010 - Elsevier BV | Energy and Buildings
Arturo Muñoz, José Alfaro, Núria Pardo, Purificación García‐Miguel, Víctor Quintero, Luis Gros, Carmen Melero, M. Antuña, Guillermo Ocete, Jorge de las Heras, Manuel Ruiz del Portal, R. Huguet, María Soledad Maldonado,
Tópico(s): CAR-T cell therapy research
2009 - Springer Science+Business Media | Clinical & Translational Oncology
Roser Montagud‐Martínez, María Heras‐Hernández, Lucas Goiriz, José‐Antonio Daròs, Guillermo Rodrigo,
DNA nanotechnology, and DNA computing in particular, has grown extensively over the past decade to end with a variety of functional stable structures and dynamic circuits. However, the use as designer elements of regular DNA pieces, perfectly complementary double strands, has remained elusive. Here, we report the exploitation of CRISPR-Cas systems to engineer logic circuits based on isothermal strand displacement that perform with toehold-free double-stranded DNA. We designed and implemented molecular ...
Tópico(s): Advanced Memory and Neural Computing
2021 - American Chemical Society | ACS Synthetic Biology
Valentín García‐Gutiérrez, Alejandra Martínez‐Trillos, José Luis López Lorenzo, Guiomar Bautista, María Luisa Martín Mateos, Alberto Álvarez‐Larrán, Ana Iglesias Pérez, Andrés Romo Collado, Ángeles Fernández, Angeles Portero, Beatriz Cuevas, Concepción Ruíz, Esperanza Romero, Fernando Ramos Ortega, Isabel Mata, J. Ríos Tallón, María del Carmen García Garay, María José Ramirez Sánchez, Natalia de las Heras, Pilar Giraldo, Sabela Bobillo, José María Guinea de Castro, Guillermo Debén, Sandra Elizabeth Villacís Valencia, Ana Sebrango, Concepción Boqué, Begoña Maestro, Juan Luis Steegmann,
The role of bosutinib as rescue treatment of Philadelphia chromosome-positive chronic myeloid leukemia (CML) patients after failing three previous tyrosine kinase inhibitors (TKIs) is currently unknown. We report here the largest series (to our knowledge) of patients treated with bosutinib in fourth-line, after retrospectively reviewing 30 patients in chronic phase, and pretreated with imatinib, nilotinib, and dasatinib. With a median follow up of 11.1 months, the probability to either maintain or ...
Tópico(s): Eosinophilic Disorders and Syndromes
2015 - Wiley | American Journal of Hematology
Ernesto Pérez Persona, Gema Mateo, Ramón García‐Sánz, María‐Victoria Mateos, Natalia de las Heras, Alfonso García de Coca, José M. Hernández, Josefina Galende, Guillermo Martín–Núñez, Abelardo Bárez, José María Alonso, Alejandro Martı́n, C López-Berges, Alberto Órfão, Jesús F. San Miguel, María‐Belén Vidriales,
The present study explored the impact of two novel criteria; having >95% abnormal plasma cells by flow cytometry at diagnosis and the evolving subtype of the disease, as predictors of progression in 61 smouldering multiple myeloma (SMM) and 311 monoclonal gammopathy of unknown significance (MGUS) patients. Although both criteria were of prognostic value, the risk of progression was better identified by immunophenotyping [Hazard Ratio (HR) 6.2 and 17.2 for SMM and MGUS, respectively] than evolving subtype, ...
Tópico(s): Platelet Disorders and Treatments
2009 - Wiley | British Journal of Haematology
J.L. Navarro-Hermoso, Guillermo Espinosa-Rueda, Carlos Heras, Íñigo Salinas, Noelia Martínez, M. V. Gallas,
Parabolic trough is the most extended solar thermoelectric technology. Solar radiation is converted into heat and transferred to the heat transfer fluid in the solar receiver tubes. The thermal energy obtained feeds a conventional Rankine power cycle. The performance of the receiver tube can be broken down into three single components: the optical transmittance of the outer glass envelope or capability in transmitting the radiant energy; the optical absorptance of the metal tube or capability to ...
Tópico(s): solar cell performance optimization
2016 - Elsevier BV | Solar Energy
Ana E. Rodriguez, José‐Ángel Hernández‐Rivas, Rocío Benito, Norma C. Gutiérrez, Juan Luis Garcı́a, María Hernández‐Sánchez, Alberto Risueño, María Eugenia Sarasquete, Encarnación Fermiñán, Rosa Fisac, Alfonso García de Coca, Guillermo Martín–Núñez, Natalia de las Heras, Isabel Recio, Oliver Gutiérrez, Javier De Las Rivas, Marcos González, Jesús María Hernández‐Rivas,
Background Patients with chronic lymphocytic leukemia and 13q deletion as their only FISH abnormality could have a different outcome depending on the number of cells displaying this aberration. Thus, cases with a high number of 13q- cells (13q-H) had both shorter overall survival and time to first therapy. The goal of the study was to analyze the genetic profile of 13q-H patients. Design and Methods: A total of 102 samples were studied, 32 of which served as a validation cohort and five were healthy ...
Tópico(s): Immunodeficiency and Autoimmune Disorders
2012 - Public Library of Science | PLoS ONE
Daniel R. Prado, Jesús A. López‐Fernández, Guillermo Barquero, Manuel Arrebola, Fernando Las‐Heras,
This paper describes the characterization of reflectarray unit cells using support vector machines (SVMs) to obtain fast and accurately the full matrix of reflection coefficients, which is used for an analysis of dual-polarized reflectarrays, demonstrating the performance of the model. First, a surrogate model of the reflectarray unit cell is obtained using SVMs. To this end, a set of random samples of the reflection coefficient matrix with a full-wave method of moments based on local periodicity ( ...
Tópico(s): Metamaterials and Metasurfaces Applications
2018 - IEEE Antennas & Propagation Society | IEEE Transactions on Antennas and Propagation