José Páez, Guillermo Hevia, Florencia Pesci, Hugo H. Rabbia,
Se construye y valida psicométricamente una escala de actitudes negativas hacia personas trans (EANT) como expresión del prejuicio hacia las mismas. Se reportan dos estudios secuenciales interdependientes por cuestionarios a partir de muestreos no probabilísticos. El estudio 1, con 203 participantes, en su mayoría estudiantes universitarios, aborda la construcción y análisis exploratorio de la EANT. El estudio 2, con 408 participantes según cuotas sociodemográficas establecidas por el censo nacional ...
Tópico(s): Psychology of Moral and Emotional Judgment
2015 - Pontifical Catholic University of Peru | Revista de Psicología
Laisel Martinez, Juan C. Duque, Marwan Tabbara, Angela Paez, Guillermo Selman, Diana R. Hernández, Chad Sundberg, Jason Chieh Sheng Tey, Yan-Ting Shiu, Alfred K. Cheung, Michael Allon, Omaida C. Velázquez, Loay Salman, Roberto I. Vázquez-Padrón,
The frequency of primary failure in arteriovenous fistulas (AVFs) remains unacceptably high. This lack of improvement is due in part to a poor understanding of the pathobiology underlying AVF nonmaturation. This observational study quantified the progression of three vascular features, medial fibrosis, intimal hyperplasia (IH), and collagen fiber organization, during early AVF remodeling and evaluated the associations thereof with AVF nonmaturation. We obtained venous samples from patients undergoing ...
Tópico(s): Vascular Malformations Diagnosis and Treatment
2018 - American Society of Nephrology | Journal of the American Society of Nephrology
Germán Buitrón, Karla M. Muñoz-Páez, Guillermo Quijano, Julián Carrillo‐Reyes, Blanca Aidé Albarrán-Contreras,
Abstract BACKGROUND Fermentative hydrogen production has an inherent limitation caused by hydrogen‐consuming metabolic pathways such as homoacetogenesis related to high hydrogen partial pressures. In this study, a strategy based on recirculating the headspace gas was applied to increase the hydrogen release from the liquid to the gas phase in an upflow anaerobic sludge blanket(UASB) reactor fed with winery effluents. The influence of the gas upflow recirculation velocity on hydrogen production, ...
Tópico(s): Microbial Metabolic Engineering and Bioproduction
2019 - Wiley | Journal of Chemical Technology & Biotechnology
Lecia V. Sequist, Scott Gettinger, Neil Senzer, Renato Martins, Pasi A. Jänne, Rogerio Lilenbaum, Jhanelle E. Gray, A. John Iafrate, Ryohei Katayama, Nafeeza Hafeez, Jennifer Sweeney, John R. Walker, Christian Fritz, Robert W. Ross, David Grayzel, Jeffrey A. Engelman, Darrell R. Borger, Guillermo Paez, Ronald B. Natale,
Purpose IPI-504 is a novel, water-soluble, potent inhibitor of heat-shock protein 90 (Hsp90). Its potential anticancer activity has been validated in preclinical in vitro and in vivo models. We studied the activity of IPI-504 after epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) therapy in patients with advanced, molecularly defined non–small-cell lung cancer (NSCLC). Patients and Methods Patients with advanced NSCLC, prior treatment with EGFR TKIs, and tumor tissue available ...
Tópico(s): ATP Synthase and ATPases Research
2010 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Emmanuel Normant, Guillermo Paez, Kip A. West, Alice R. Lim, Kelly L. Slocum, Chris Tunkey, James K. McDougall, Andrew Wylie, Keith Robison, K. Caliri, Vito J. Palombella, Christian Fritz,
Heat shock protein 90 (Hsp90) is an emerging target for cancer therapy due to its important role in maintaining the activity and stability of key oncogenic signaling proteins. We show here that the echinoderm microtubule-associated protein-like 4 (EML4)–anaplastic lymphoma kinase (ALK) fusion protein, presumed to be the oncogenic driver in about 5% of patients with non-small cell lung cancer (NSCLC), is associated with Hsp90 in cells and is rapidly degraded upon exposure of cells to IPI-504. We find ...
Tópico(s): Veterinary medicine and infectious diseases
2011 - Springer Nature | Oncogene
Jeffrey C. Lee, Igor Vivanco, Rameen Beroukhim, Julie H. Huang, Whei Feng, Ralph DeBiasi, Koji Yoshimoto, Jennifer C. King, Phioanh L. Nghiemphu, Yuki Yuza, Qing Xu, Heidi Greulich, Roman K. Thomas, J. Guillermo Paez, Timothy C. Peck, David Linhart, Karen A. Glatt, Gad Getz, Robert C. Onofrio, Liuda Ziaugra, Ross L. Levine, Stacey Gabriel, Tomohiro Kawaguchi, Keith O'Neill, Haumith Khan, Linda M. Liau, Stanley F. Nelson, P. Nagesh Rao, Paul S. Mischel, Russell O. Pieper, Tim Cloughesy, Daniel J. Leahy, William R. Sellers, Charles L. Sawyers, Matthew Meyerson, Ingo K. Mellinghoff,
Protein tyrosine kinases are important regulators of cellular homeostasis with tightly controlled catalytic activity. Mutations in kinase-encoding genes can relieve the autoinhibitory constraints on kinase activity, can promote malignant transformation, and appear to be a major determinant of response to kinase inhibitor therapy. Missense mutations in the EGFR kinase domain, for example, have recently been identified in patients who showed clinical responses to EGFR kinase inhibitor therapy.Encouraged ...
Tópico(s): Melanoma and MAPK Pathways
2006 - Public Library of Science | PLoS Medicine
J. Guillermo Paez, Juan A. Recio, Ana Rouzaut, Vicente Notario,
PCPH was initially defined as a proto-oncogene on the basis of its frequent detection as an activated oncogene in tumorigenic Syrian hamster embryo fibroblast cell lines converted to the neoplastic state by a single treatment with the carcinogen 3-methylcholanthrene (MC). Further studies identified the translation product of the PCPH gene as a ribonucleotide-binding protein with special affinity for ribonucleoside diphosphates. Later, we showed that the PCPH protein was homologous to the product ...
Tópico(s): Nuclear Receptors and Signaling
2001 - Spandidos Publishing | International Journal of Oncology
Reuben J. Shaw, J. Guillermo Paez, Marcello Curto, Ann L. Yaktine, Wendy M. Pruitt, Ichiko Saotome, John P. O’Bryan, Vikas A. Gupta, Nancy Ratner, Channing J. Der, Tyler Jacks, Andrea I. McClatchey,
Mutations in the neurofibromatosis type II (NF2) tumor suppressor predispose humans and mice to tumor development. The study of Nf2+/− mice has demonstrated an additional effect of Nf2 loss on tumor metastasis. The NF2-encoded protein, merlin, belongs to the ERM (ezrin, radixin, and moesin) family of cytoskeleton:membrane linkers. However, the molecular basis for the tumor- and metastasis- suppressing activity of merlin is unknown. We have now placed merlin in a signaling pathway downstream of the ...
Tópico(s): Microtubule and mitosis dynamics
2001 - Elsevier BV | Developmental Cell
Torstein Tengs, Jeff C. Lee, J. Guillermo Paez, Xiao‐Jun Zhao, Thomas LaFramboise, Georgia Giannoukos, Roman K. Thomas,
We have designed resequencing microarrays to test the performance of this platform when interrogating a large number of exons (164 total) from genes associated with cancer. To evaluate false positive and negative rates, dideoxy sequencing was done for 335,420 bases interrogated by the arrays. From the array data, calls could be made for ∼97.5% of the bases, and false positive rates were very low with only a single mutation reported from the array dataset for which the corresponding dideoxy trace had ...
Tópico(s): Liver physiology and pathology
2005 - Elsevier BV | Cancer Letters
Major efforts are underway to systematically define the somatic and germline genetic variations causally associated with disease. Genome-wide genetic analysis of actual clinical samples is, however, limited by the paucity of genomic DNA available. Here we have tested the fidelity and genome representation of phi29 polymerase-based genome amplification (phi29MDA) using direct sequencing and high density oligonucleotide arrays probing >10,000 SNP alleles. Genome representation was comprehensive and ...
Tópico(s): Genomics and Phylogenetic Studies
2004 - Oxford University Press | Nucleic Acids Research
J. Guillermo Paez, Pasi A. Jänne, Jeffrey C. Lee, Sean Tracy, Heidi Greulich, Stacey Gabriel, Paula Herman, Frederic J. Kaye, Neal I. Lindeman, Titus J. Boggon, Katsuhiko Naoki, Hidefumi Sasaki, Yoshitaka Fujii, Michael J. Eck, William R. Sellers, Bruce E. Johnson, Matthew Meyerson,
Receptor tyrosine kinase genes were sequenced in non–small cell lung cancer (NSCLC) and matched normal tissue. Somatic mutations of the epidermal growth factor receptor gene EGFR were found in 15of 58 unselected tumors from Japan and 1 of 61 from the United States. Treatment with the EGFR kinase inhibitor gefitinib (Iressa) causes tumor regression in some patients with NSCLC, more frequently in Japan. EGFR mutations were found in additional lung cancer samples from U.S. patients who responded to gefitinib ...
Tópico(s): Colorectal Cancer Treatments and Studies
2004 - American Association for the Advancement of Science | Science
Xiaojun Zhao, Cheng Li, J. Guillermo Paez, Koei Chin, Pasi A. Jänne, Tzu-Hsiu Chen, Luc Girard, John D. Minna, David C. Christiani, Chris Leo, Joe W. Gray, William R. Sellers, Matthew Meyerson,
Abstract Changes in DNA copy number contribute to cancer pathogenesis. We now show that high-density single nucleotide polymorphism (SNP) arrays can detect copy number alterations. By hybridizing genomic representations of breast and lung carcinoma cell line and lung tumor DNA to SNP arrays, and measuring locus-specific hybridization intensity, we detected both known and novel genomic amplifications and homozygous deletions in these cancer samples. Moreover, by combining genotyping with SNP quantitation, ...
Tópico(s): Chromosomal and Genetic Variations
2004 - American Association for Cancer Research | Cancer Research
Mohamed Bentires‐Alj, J. Guillermo Paez, Frank David, Heike Keilhack, Balázs Halmos, Katsuhiko Naoki, John M. Maris, Andrea L. Richardson, Alberto Bardelli, David J. Sugarbaker, William G. Richards, Jinyan Du, Luc Girard, John D. Minna, Mignon L. Loh, David E. Fisher, Victor E. Velculescu, Bert Vogelstein, Matthew Meyerson, William R. Sellers, Benjamin G. Neel,
Abstract The SH2 domain-containing protein-tyrosine phosphatase PTPN11 (Shp2) is required for normal development and is an essential component of signaling pathways initiated by growth factors, cytokines, and extracellular matrix. In many of these pathways, Shp2 acts upstream of Ras. About 50% of patients with Noonan syndrome have germ-line PTPN11 gain of function mutations. Associations between Noonan syndrome and an increased risk of some malignancies, notably leukemia and neuroblastoma, have been ...
Tópico(s): PI3K/AKT/mTOR signaling in cancer
2004 - American Association for Cancer Research | Cancer Research
Jingrui Jiang, J. Guillermo Paez, Jeffrey C. Lee, Ronghai Bo, Richard M. Stone, Daniel J. DeAngelo, Ilene Galinsky, Brian M. Wolpin, Anna Jonášová, Paula Herman, Edward A. Fox, Titus J. Boggon, Michael J. Eck, Ellen Weisberg, James D. Griffin, D. Gary Gilliland, Matthew Meyerson, William R. Sellers,
Abstract The FLT3 receptor is activated by juxtamembrane insertion mutations and by activation loop point mutations in patients with acute myeloid leukemia (AML). In a systematic tyrosine kinase gene exon resequencing study, 21 of 24 FLT3 exons were sequenced in samples from 53 patients with AML, 9 patients with acute lymphoblastic leukemia (ALL), and 3 patients with myelodysplasia samples. Three patients had novel point mutations at residue N841 that resulted in a change to isoleucine in 2 samples ...
Tópico(s): Chronic Lymphocytic Leukemia Research
2004 - Elsevier BV | Blood
Juan C. Duque, Marwan Tabbara, Laisel Martinez, Angela Paez, Guillermo Selman, Loay Salman, Omaida C. Velázquez, Roberto I. Vázquez-Padrón,
Intimal hyperplasia has been historically associated with improper venous remodeling and stenosis after creation of an arteriovenous fistula. Recently, however, we showed that intimal hyperplasia by itself does not explain the failure of maturation of 2-stage arteriovenous fistulas. We seek to evaluate whether intimal hyperplasia plays a role in the development of focal stenosis of an arteriovenous fistula.This study compares intimal hyperplasia lesions in stenotic and nearby nonstenotic segments ...
Tópico(s): Vascular Procedures and Complications
2017 - Elsevier BV | Surgery
Rodrigo Otávio Silveira Silva, Fernando Medrano, Ivo Tejeda, Daniel Terán, Ronny Peredo, Rodrigo Barros, Valentina Colodro, Paola González, Verónica González, Carlos Guerra-Correa, Peter Hodum, Brad Keitt, Guillermo Luna‐Jorquera, Vinko Malinarich, Gabriela Mallea, Pablo Suárez Manríquez, Hannah Nevins, Bárbara Olmedo, Jorge Páez-Godoy, Guillermo De Rodt, Flora Rojas, Pedro Pérez Sanhueza, Cristián G. Suazo, Frederick Caicedo Toro, Bárbara Toro-Barros,
La contaminación lumínica afecta a las aves marinas por la atracción hacia fuentes de luz y su posterior caída (fallout) en todo el mundo, siendo los petreles y fardelas las especies más afectadas. La contaminación lumínica está aumentando globalmente y probablemen- te sus efectos sobre estas aves se incrementen en los próximos años. Pese a que existe una evaluación global de esta materia, no existe in- formación detallada para Sudamérica; por esto, el objetivo de este artículo es elaborar ...
Tópico(s): Wildlife Conservation and Criminology Analyses
2020 - | Ornitología Neotropical
Bienvenido Ros, A.M. Jaramillo-Dallimonti, Luis Segundo de Miguel-Pueyo, S. Rodríguez-Barceló, Miguel Domínguez-Páez, Guillermo Ibáñez-Botella, Bernarda Márquez-Márquez, Miguel Ángel Arráez-Sánchez,
Aproximadamente el 50% de los pacientes pretérminos diagnosticados de hemorragia intraventricular desarrollará una hidrocefalia posthemorrágica. La derivación ventrículo-peritoneal de LCR puede constituir en muchos casos la única opción de tratamiento definitivo, aunque se han descrito elevados porcentajes de complicaciones infecciosas o por obstrucción, existiendo además debate sobre cual es el momento más adecuado para la intervención. Presentar un protocolo de diagnóstico y tratamiento de la ...
Tópico(s): Neuroscience of respiration and sleep
2009 - Elsevier BV | Neurocirugía
Juan C. Duque, Laisel Martinez, Marwan Tabbara, Punam P. Parikh, Angela Paez, Guillermo Selman, Loay Salman, Omaida C. Velázquez, Roberto I. Vázquez-Padrón,
Background and objectives: The venous vasa vasorum is the mesh of microvessels that provide oxygen and nutrients to the walls of large veins. Whether changes to the vasa vasorum have any effects on human arteriovenous fistula outcomes remains undetermined. In this study, we challenged the hypothesis that inadequate vascularization of the arteriovenous fistula wall is associated with maturation failure. Design, setting, participants, and measurements: This case–control pilot study includes pre-access ...
Tópico(s): Vascular Malformations and Hemangiomas
2019 - SAGE Publishing | The Journal of Vascular Access
Sylvia Haas, Walter Ageno, Jeffrey I. Weitz, Samuel Z. Goldhaber, Alexander G.G. Turpie, Shinya Goto, Pantep Angchaisuksiri, Joern Dalsgaard Nielsen, Gloria Kayani, Audrey Zaghdoun, Alfredo E. Farjat, Sebastian Schellong, Henri Bounameaux, LG Mantovani, Paolo Prandoni, Ajay K. Kakkar, A. Loualidi, Abdürrahim Çolak, Abraham F. Bezuidenhout, A.T.O. Abdool-Carrim, Addala Azeddine, Adriaan Beyers, A Dees, Ahmed Mohamed, Ahmet Aksoy, Akihiko Abiko, Akinori Watanabe, Alan Krichell, Alberto Alfredo Fernandez, Alberto Tosetto, Alexey Khotuntsov, Alisha Oropallo, Alison Slocombe, Allan Kelly, Amanda Clark, Amr Gad, Amy Arouni, Andor Schmidt, Andrea Berni, Andres Javier Kleiban, A Machowski, Andrey Kazakov, Ángel Gálvez, Ann Lockman, Anna Falanga, Anoop Chauhan, Antoni Riera‐Mestre, Antonino Mazzone, Armando D’Angelo, Artur Haddad Herdy, Atsushi Kato, Ayman Abd Elhamid Ebrahim, Mahmoud Salem, Azlan Husin, Barbara Erdelyi, Barry Jacobson, Beatrice Amann‐Vesti, Bektaş Battaloğlu, Benedicte Wilson, Benilde Cosmi, Bergmann Jean Francois, Berremeli Toufek, Beverley Hunt, Bhavesh Natha, Bisher Mustafa, Bonnie Chi Shan Kho, Boulon Carine, Brian Zidel, Brisot Dominique, Brousse Christophe, Bruno Trimarco, Canhua Luo, Carlos Alberto Cuneo, Carlos Jerjes‐Sánchez, Carsten Schwencke, Cas Cader, Celal Yavuz, Cesar Javier Zaidman, Charles A. Lunn, Chau‐Chung Wu, Cheng Hock Toh, Chern‐En Chiang, Chevrier Elisa, Chien‐Hsun Hsia, Chien‐Lung Huang, Chi‐Hang Kevin Kwok, Chih‐Cheng Wu, Chi‐Hung Huang, Chris Ward, Christian Opitz, Christina Jeanneret‐Gris, Chung Yin Ha, Chun‐Yao Huang, Claude Luyeye Bidi, Clifford Smith, Cornelia Brauer, Corrado Lodigiani, Françis Couturaud, Cynthia Wu, Daniel Staub, Daniel Theodoro, D. Poli, Riesco Acevedo, David Adler, David Jiménez, David Keeling, David Scott, Davide Imberti, Desmond Creagh, Desmurs‐Clavel Helene, Dirk Hagemann, Dirk Le Roux, Dirk Skowasch, Dmitry Belenky, Dmitry Dorokhov, Dmitry Petrov, D. A. Zateyshchikov, Domenico Prisco, Dorthe Svenstrup Møller, Dusan Kucera, Ehab M. Esheiba, Е. П. Панченко, Elkouri Dominique, Emre Doğan, Emre Kubat, Enrique Diaz Diaz, Eric Wai Choi Tse, Erik Yeo, Erman Hashas, Ernst Gröchenig, Eros Tiraferri, Erwin Blessing, E Michele, Esther Usandizaga, Ettore Porreca, Fabián Ferroni, Falvo Nicolas, F. Ayala‐Paredes, Firas Koura, Fitjerald Henry, Franco Cosmi, Frans Erdkamp, Gadel Kamalov, Garcia‐Bragado Dalmau, Garrigues Damien, Garry Klein, Gaurand Shah, Geert Hollanders, Geno J. Merli, Georg Plassmann, George Platt, Germain Poirier, German Sokurenko, Ghassan Haddad, Gholam Ali, Giancarlo Agnelli, Gin Gin Gan, Grace Kaye‐Eddie, Grégoire Le Gal, Gregory Allen, Guillermo Antonio Llamas Esperón, Guillot Jean‐Paul, Hagen Gerofke, Hallah Elali, Hana Burianová, Hans‐Juergen Ohler, Haofu Wang, Harald Darius, Harinder Gogia, Harry Striekwold, Harry Gibbs, Hatice Canan Hasanoğlu, Hatice Türker, Hendrik Franow, Herbert De Raedt, Herman Schroë, Hesham Salah ElDin, Hesham Zidan, Hiroaki Nakamura, Ho Young Kim, Holger Lawall, Hong Zhu, Hongyan Tian, Ho‐Young Yhim, Hugo Ten Cate, Hun-Gyu Hwang, Hyeok Shim, Igor Kim, И. А. Либов, Igor Sonkin, I.А. Suchkov, Ik‐Chan Song, İlker Kiriş, И Н Староверов, Irene Looi, Isabel M. De La Azuela Tenorio, İsmail Savaş, И. Г. Гордеев, Ivo Podpera, Jae Hoon Lee, Jameela Sathar, James Welker, Jan Beyer‐Westendorf, J Kvasnička, Jan Vanwelden, J.I. Kim, Jaromira Svobodova, Jaspal Gujral, Javier Marino, Javier Tristan Galvar, Jeannine Kassis, Jen‐Yuan Kuo, Jhih‐Yuan Shih, Jihyun Kwon, Jin Hyun Joh, Jin Hyun Park, Jin Seok Kim, Jinghua Yang, J Krupicka, Jiří Laštůvka, Jiri Pumprla, Jiří Veselý, Juan Carlos Souto, João Antônio Corrêa, Johan Duchateau, John Perry Fletcher, J. del Toro, J. del Toro, Jorge Guillermo Chavez Paez, Jose Dalmo Araujo Filho, José Francisco Kerr Saraiva, José Antonio Díaz Peromingo, Jose Lara, José Luis Fedele, José María Suriñach, Joseph Chacko, Juan Muntaner, Juan Carlos Álvarez Benitez, Juan Moreno Hoyos Abril, Julian Humphrey, Julio Bono, Junji Kanda, Juree Boondumrongsagoon, Kai Hang Yiu, Kanchana Chansung, Karin A. Boomars, Kate Burbury, Katsuhiro Kondo, Kemal Karaarslan, Kensuke Takeuchi, Knut Kroeger, Konstantin Zrazhevskiy, Koscál Svatopluk, Kou‐Gi Shyu, Kristel Vandenbosch, Kuan‐Cheng Chang, Kuan‐Ming Chiu, Kubina Jean‐Manuel, Zhi‐Cheng Jing, Kwo‐Chang Ueng, Lalita Norasetthada, L Binet, Lee Ping Chew, Lei Zhang, Leone Maria Cristina, Lidwine W. Tick, Lilia Beatriz Schiavi, Lily Lee Lee Wong, Lohana Borges, Louis Botha, Luc Capiau, Luc Timmermans, Luciano Eduardo López, Luigi Ria, Luis Blasco, Luis Alberto Guzman, Luis Flota Cervera, Mahe Isabelle, Manuel Monreal Bosch, Manuel de los Rios Ibarra, Manuel Núñez Fernandez, Marc Carrier, Marcelo Barrionuevo, Marco Antonio Alcocer Gamba, Marco Cattaneo, Marco Moia, Margaret Bowers, Mariam Chetanachan, Mario Alberto Berli, Mark Fixley, Markus Faghih, Markus Stüecker, Marlin Schul, Martin Banyai, Martín Koretzky, Martin Myriam,
Parenteral anticoagulants and vitamin K antagonists (VKAs) have constituted the cornerstone of venous thromboembolism (VTE) treatment. Meanwhile, direct oral anticoagulants (DOACs) provide physicians with an alternative. The Global Anticoagulant Registry in the FIELD (GARFIELD)-VTE observes real-world treatment practices.Describe initial anticoagulation (AC) treatment patterns in VTE patients who received parenteral AC, VKAs, and/or DOACs within ±30 days of diagnosis.VTE patients were categorized into ...
Elsevier BV
Alexander G.G. Turpie, Alfredo E. Farjat, Sylvia Haas, Walter Ageno, Jeffrey I. Weitz, Samuel Z. Goldhaber, Shinya Goto, Pantep Angchaisuksiri, Gloria Kayani, Renato D. Lópes, Chern‐En Chiang, Harry Gibbs, Eric Tse, Peter Verhamme, Hugo Ten Cate, Juan Muntaner, Sebastian Schellong, Henri Bounameaux, Paolo Prandoni, Uma Maheshwari, Ajay K. Kakkar, A. Loualidi, Abdürrahim Çolak, Abraham F. Bezuidenhout, A.T.O. Abdool-Carrim, Addala Azeddine, Adriaan Beyers, A Dees, Ahmed Mohamed, Ahmet Aksoy, Akihiko Abiko, Akinori Watanabe, Alan Krichell, Alberto Alfredo Fernandez, Alberto Tosetto, Alexey Khotuntsov, Alisha Oropallo, Alison Slocombe, Allan Kelly, Amanda Clark, Amr Gad, Amy Arouni, Andor Schmidt, Andrea Berni, Andres Javier Kleiban, A Machowski, Andrey Kazakov, Ángel Gálvez, Ann Lockman, Anna Falanga, Anoop Chauhan, Antoni Riera‐Mestre, Antonino Mazzone, Armando D’Angelo, Artur Haddad Herdy, Atsushi Kato, Ayman Abd Elhamid Ebrahim Mahmoud Salem, Azlan Husin, Barbara Erdelyi, Barry Jacobson, Beatrice Amann‐Vesti, Bektaş Battaloğlu, Benedicte Wilson, Benilde Cosmi, Bergmann Jean Francois, Berremeli Toufek, Beverley Hunt, Bhavesh Natha, Bisher Mustafa, Bonnie Chi Shan Kho, Boulon Carine, Brian Zidel, Brisot Dominique, Brousse Christophe, Bruno Trimarco, Canhua Luo, Carlos Alberto Cuneo, Carlos Jerjes‐Sánchez, Carsten Schwencke, Cas Cader, Celal Yavuz, Cesar Javier Zaidman, Charles A. Lunn, Chau‐Chung Wu, Cheng Hock Toh, Chern‐En Chiang, Chevrier Elisa, Chien‐Hsun Hsia, Chien-Lung Huang, Chi‐Hang Kevin Kwok, Chih-Cheng Wu, Chi‐Hung Huang, Chris Ward, Christian Opitz, Christina Jeanneret‐Gris, Chung Yin Ha, Chun‐Yao Huang, Claude Luyeye Bidi, Clifford Smith, Cornelia Brauer, Corrado Lodigiani, Françis Couturaud, Cynthia Wu, Daniel Staub, Daniel Theodoro, Daniela Poli, David Acevedo, David Adler, David Jiménez, David Keeling, David Scott, Davide Imberti, Desmond Creagh, Desmurs‐Clavel Helene, Dirk Hagemann, Dirk Le Roux, Dirk Skowasch, Dmitry Belenky, Dmitry Dorokhov, Dmitry Petrov, D. A. Zateyshchikov, Domenico Prisco, Dorthe Svenstrup Møller, Dusan Kucera, Ehab M. Esheiba, Е. П. Панченко, Elkouri Dominique, Emre Doğan, Emre Kubat, Enrique Diaz Diaz, Eric Wai Choi Tse, Erik Yeo, Erman Hashas, Ernst Gröchenig, Eros Tiraferri, Erwin Blessing, E Michele, Esther Usandizaga, Ettore Porreca, Fabián Ferroni, Falvo Nicolas, Félix Ayala-Paredes, Firas Koura, Fitjerald Henry, Franco Cosmi, Frans Erdkamp, Gadel Kamalov, Garcia‐Bragado Dalmau, Garrigues Damien, Garry Klein, Gaurand Shah, Geert Hollanders, Geno J. Merli, Georg Plassmann, George Platt, Germain Poirier, German Sokurenko, Ghassan Haddad, Gholam Ali, Giancarlo Agnelli, Gin Gin Gan, Grace Kaye‐Eddie, Grégoire Le Gal, Gregory Allen, Guillermo Antonio Llamas Esperón, Guillot Jean‐Paul, Hagen Gerofke, Hallah Elali, Hana Burianová, Hans‐Juergen Ohler, Haofu Wang, Harald Darius, Harinder Gogia, Harry Striekwold, Harry Gibbs, Hatice Canan Hasanoğlu, Hatice Türker, Hendrik Franow, Henri Bounameaux, Herbert De Raedt, Herman Schroë, Hesham Salah ElDin, Hesham Zidan, Hiroaki Nakamura, Ho Young Kim, Holger Lawall, Hong Zhu, Hongyan Tian, Ho‐Young Yhim, Hugo Ten Cate, Hun-Gyu Hwang, Hyeok Shim, Igor Kim, И. А. Либов, Igor Sonkin, I.А. Suchkov, Ik‐Chan Song, İlker Kiriş, И Н Староверов, Irene Looi, Isabel M. De La Azuela Tenorio, İsmail Savaş, И. Г. Гордеев, Ivo Podpera, Jae Hoon Lee, Jameela Sathar, James Welker, Jan Beyer‐Westendorf, J Kvasnička, Jan Vanwelden, J.I. Kim, Jaromira Svobodova, Jaspal Gujral, Javier Marino, Javier Tristan Galvar, Jeannine Kassis, Jen‐Yuan Kuo, Jhih-Yuan Shih, Jihyun Kwon, Jin Hyun Joh, Jin Hyun Park, Jin Seok Kim, Jinghua Yang, J Krupicka, Jiří Laštůvka, Jiri Pumprla, Jiří Veselý, Juan Carlos Souto, João Antônio Corrêa, Johan Duchateau, John Perry Fletcher, J. del Toro, J. del Toro, Jorge Guillermo Chavez Paez, Jørn Dalsgaard Nielsen, Jose Dalmo Araujo Filho, José Francisco Kerr Saraiva, José Antonio Díaz Peromingo, Jose Lara, José Luis Fedele, José María Suriñach, Joseph Chacko, Juan Muntaner, Juan Carlos Álvarez Benitez, Juan Moreno Hoyos Abril, Julian Humphrey, Julio Bono, Junji Kanda, Juree Boondumrongsagoon, Kai Hang Yiu, Kanchana Chansung, Karin A. Boomars, Kate Burbury, Katsuhiro Kondo, Kemal Karaarslan, Kensuke Takeuchi, Knut Kroeger, Konstantin Zrazhevskiy, Koscál Svatopluk, Kou‐Gi Shyu, Kristel Vandenbosch, Kuan‐Cheng Chang, Kuan‐Ming Chiu, Kubina Jean‐Manuel, Zhi‐Cheng Jing, Kwo‐Chang Ueng, Lalita Norasetthada, L Binet, Lee Ping Chew, Lei Zhang, Leone Maria Cristina, Lidwine W. Tick, Lilia Beatriz Schiavi, Lily Lee Lee Wong, Lohana Borges, Louis Botha, Luc Capiau, Luc Timmermans, Luciano Eduardo López, Luigi Ria, Luis Blasco, Luis Alberto Guzman, Luis Flota Cervera, Mahe Isabelle, Manuel Monreal Bosch, Manuel de los Rios Ibarra, Manuel Núñez Fernandez, Marc Carrier, Marcelo Barrionuevo, Marco Antonio Alcocer Gamba, Marco Cattaneo, Marco Moia, Margaret Bowers, Mariam Chetanachan, Mario Alberto Berli, Mark Fixley,
Venous thromboembolism (VTE), encompassing both deep vein thrombosis (DVT) and pulmonary embolism (PE), is a leading cause of morbidity and mortality worldwide.GARFIELD-VTE is a prospective, non-interventional observational study of real-world treatment practices. We aimed to capture the 36-month clinical outcomes of 10,679 patients with objectively confirmed VTE enrolled between May 2014 and January 2017 from 415 sites in 28 countries.A total of 6582 (61.6 %) patients had DVT alone, 4097 (38.4 %) had PE ± DVT. ...
Elsevier BV
Fredy Guillermo Rodríguez-Páez, Wilson Giovanni Jiménez Barbosa, Cindy Alejandra Jiménez-González, Ángela Edith Coral-Córdoba, Paola Carolina Ramírez-Solano, Néstor Raúl Ramos-Navas,
determinar qué condiciones pueden explicar la inasistencia a citas programadas de control prenatal(cpn) y evaluar si la eliminación de las barreras de acceso mejora las condiciones de salud de las gestantes.Metodología: se realizó un estudio de diseño mixto, multietápico, de cohorte prospectivo. Resultados: ladificultad para el pago de transporte fue la principal barrera de acceso causante de inasistencia. Mediantela entrega de subsidios de transporte, las inasistencias disminuyeron 87 %. Los determinantes ...
Tópico(s): Child and Adolescent Health
2014 - | Gerencia y Políticas de Salud
Jeffrey I. Weitz, Sylvia Haas, Walter Ageno, Samuel Z. Goldhaber, Alexander G.G. Turpie, Shinya Goto, Pantep Angchaisuksiri, Jørn Dalsgaard Nielsen, Gloria Kayani, Alfredo E. Farjat, Sebastian Schellong, Henri Bounameaux, LG Mantovani, Paolo Prandoni, Ajay K. Kakkar, A. Loualidi, Abdürrahim Çolak, Abraham F. Bezuidenhout, A.T.O. Abdool-Carrim, Addala Azeddine, Adriaan Beyers, A Dees, Ahmed Mohamed, Ahmet Aksoy, Akihiko Abiko, Akinori Watanabe, Alan Krichell, Alberto Alfredo Fernandez, Alberto Tosetto, Alexey Khotuntsov, Alisha Oropallo, Alison Slocombe, Allan Kelly, Amanda Clark, Amr Gad, Amy Arouni, Andor Schmidt, Andrea Berni, Andres Javier Kleiban, A Machowski, Andrey Kazakov, Ángel Gálvez, Ann Lockman, Anna Falanga, Anoop Chauhan, Antoni Riera‐Mestre, Antonino Mazzone, Armando D’Angelo, Artur Haddad Herdy, Atsushi Kato, Ayman Abd Elhamid Ebrahim Mahmoud Salem, Azlan Husin, Barbara Erdelyi, Barry Jacobson, Beatrice Amann‐Vesti, Bektaş Battaloğlu, Benedicte Wilson, Benilde Cosmi, Bergmann Jean Francois, Berremeli Toufek, Beverley J. Hunt, Bhavesh Natha, Bisher Mustafa, Bonnie Chi Shan Kho, Boulon Carine, Brian Zidel, Brisot Dominique, Brousse Christophe, Bruno Trimarco, Canhua Luo, Carlos Alberto Cuneo, Carlos Jerjes‐Sánchez, Carsten Schwencke, Cas Cader, Celal Yavuz, Cesar Javier Zaidman, Charles A. Lunn, Chau‐Chung Wu, Cheng Hock Toh, Chern‐En Chiang, Chevrier Elisa, Chien‐Hsun Hsia, Chien-Lung Huang, Chi‐Hang Kevin Kwok, Chih-Cheng Wu, Chi‐Hung Huang, Chris Ward, Christian Opitz, Christina Jeanneret‐Gris, Chung Yin Ha, Chun‐Yao Huang, Claude Luyeye Bidi, Clifford Smith, Cornelia Brauer, Corrado Lodigiani, Françis Couturaud, Cynthia Wu, Daniel Staub, Daniel Theodoro, Daniela Poli, David Acevedo, David Adler, David Jiménez, David Keeling, David Scott, Davide Imberti, Desmond Creagh, Desmurs‐Clavel Helene, Dirk Hagemann, Dirk Le Roux, Dirk Skowasch, Dmitry Belenky, Dmitry Dorokhov, Dmitry Petrov, D. A. Zateyshchikov, Domenico Prisco, Dorthe Svenstrup Møller, Dusan Kucera, Ehab M. Esheiba, Е. П. Панченко, Elkouri Dominique, Emre Doğan, Emre Kubat, Enrique Diaz Diaz, Eric Wai Choi Tse, Erik Yeo, Erman Hashas, Ernst Gröchenig, Eros Tiraferri, Erwin Blessing, E Michele, Esther Usandizaga, Ettore Porreca, Fabián Ferroni, Falvo Nicolas, Félix Ayala-Paredes, Firas Koura, Fitjerald Henry, Franco Cosmi, Frans Erdkamp, Gadel Kamalov, Garcia‐Bragado Dalmau, Garrigues Damien, Garry Klein, Gaurand Shah, Geert Hollanders, Geno J. Merli, Georg Plassmann, George Platt, Germain Poirier, German Sokurenko, Ghassan Haddad, Gholam Ali, Giancarlo Agnelli, Gin Gin Gan, Grace Kaye‐Eddie, Grégoire Le Gal, Gregory Allen, Guillermo Antonio Llamas Esperón, Guillot Jean‐Paul, Hagen Gerofke, Hallah Elali, Hana Burianová, Hans‐Juergen Ohler, Haofu Wang, Harald Darius, Harinder Gogia, Harry Striekwold, Harry Gibbs, Hatice Canan Hasanoğlu, Hatice Türker, Hendrik Franow, Henri Bounameaux, Herbert De Raedt, Herman Schroë, Hesham Salah ElDin, Hesham Zidan, Hiroaki Nakamura, Ho Young Kim, Holger Lawall, Hong Zhu, Hongyan Tian, Ho-Young Yhim, Hugo Ten Cate, Hun-Gyu Hwang, Hyeok Shim, Igor Kim, И. А. Либов, Igor Sonkin, I.А. Suchkov, Ik‐Chan Song, İlker Kiriş, И Н Староверов, Irene Looi, Isabel M. De La Azuela Tenorio, İsmail Savaş, И. Г. Гордеев, Ivo Podpera, Jae Hoon Lee, Jameela Sathar, James Welker, Jan Beyer‐Westendorf, J Kvasnička, Jan Vanwelden, J.I. Kim, Jaromira Svobodova, Jaspal Gujral, Javier Marino, Javier Tristan Galvar, Jeannine Kassis, Jen‐Yuan Kuo, Jhih-Yuan Shih, Jihyun Kwon, Jin Hyun Joh, Jin Hyun Park, Jin Seok Kim, Jinghua Yang, J Krupicka, Jiří Laštůvka, Jiri Pumprla, Jiří Veselý, Juan Carlos Souto, João Antônio Corrêa, Johan Duchateau, John Perry Fletcher, J. del Toro, J. del Toro, Jorge Guillermo Chavez Paez, Jørn Dalsgaard Nielsen, Jose Dalmo Araujo Filho, Jose F. Kerr Saraiva, José Antonio Díaz Peromingo, Jose Lara, José Luis Fedele, José María Suriñach, Joseph Chacko, Juan Muntaner, Juan Carlos Álvarez Benitez, Juan Moreno Hoyos Abril, Julian Humphrey, Julio Bono, Junji Kanda, Juree Boondumrongsagoon, Kai Hang Yiu, Kanchana Chansung, Karin A. Boomars, Kate Burbury, Katsuhiro Kondo, Kemal Karaarslan, Kensuke Takeuchi, Knut Kroeger, Konstantin Zrazhevskiy, Koscál Svatopluk, Kou‐Gi Shyu, Kristel Vandenbosch, Kuan‐Cheng Chang, Kuan‐Ming Chiu, Kubina Jean‐Manuel, Zhi‐Cheng Jing, Kwo‐Chang Ueng, Lalita Norasetthada, L Binet, Lee Ping Chew, Lei Zhang, Leone Maria Cristina, Lidwine W. Tick, Lilia Beatriz Schiavi, Lily Lee Lee Wong, Lohana Borges, Louis Botha, Luc Capiau, Luc Timmermans, Luciano Eduardo López, Luigi Ria, Luis Blasco, Luis Alberto Guzman, Luis Flota Cervera, Mahe Isabelle, Manuel Monreal Bosch, Manuel de los Rios Ibarra, Manuel Núñez Fernandez, Marc Carrier, Marcelo Barrionuevo, Marco Antonio Alcocer Gamba, Marco Cattaneo, Marco Moia, Margaret Bowers, Mariam Chetanachan, Mario Alberto Berli, Mark Fixley, Markus Faghih, Markus Stüecker, Marlin Schul, Martin Banyai, Martín Koretzky, Martin Myriam,
Springer Science+Business Media
M. Luján, Álvaro Páez, J.C. Angulo, Guillermo Andrés, H. Gimbernat, C. Redondo, Gina Torres, Antonio Berenguer,
En la actualidad el papel del screening del cáncer de próstata (CaP) está cuestionado. El estudio aleatorizado europeo de screening del cáncer de próstata (ERSPC) tiene como objetivo demostrar si el screening del CaP reduce la mortalidad por esta enfermedad. Se muestran los resultados en la rama española de este estudio: mortalidad global y cáncer-específica, características de los tumores detectados, de los tratamientos primarios y de la progresión a enfermedad avanzada. Se invitó a participar a ...
Tópico(s): Bladder and Urothelial Cancer Treatments
2015 - Elsevier BV | Actas Urológicas Españolas
Iván Aurelio Páez-Gutiérrez, David Guillermo Hernández, Diana Vanegas, Bernardo Camacho, Ana María Perdomo-Arciniegas,
Allele and haplotype frequencies were calculated from 1463 umbilical cord blood (UCB) units, from Bogotá (Colombia) donors, HLA-typed in high resolution. This is the first report using allele-level typed colombian samples of five HLA loci related to hematopoietic stem cell transplantation (HLA-A, -B, -C, -DRB1 and -DQB1). The most frequent haplotype found in our sample was A*24:02g ∼ B*35:43g ∼ C*01:02g ∼ DRB1*04:07g ∼ DQB1*03:02g (4.14%). Our data are available at the Allele Frequencies Net Database under the ...
Tópico(s): Microbial infections and disease research
2019 - Elsevier BV | Human Immunology
Jesus Paez‐Mayorga, Gustavo Hernández‐Vargas, Guillermo U. Ruiz‐Esparza, Hafiz M.N. Iqbal, Xichi Wang, Yu Shrike Zhang, Roberto Parra‐Saldívar, Ali Khademhosseini,
Abstract The advances in biotechnology, biomechanics, and biomaterials can be used to develop organ models that aim to accurately emulate their natural counterparts. Heart disease, one of the leading causes of death in modern society, has attracted particular attention in the field of tissue engineering. To avoid incorrect prognosis of patients suffering from heart disease, or from adverse consequences of classical therapeutic approaches, as well as to address the shortage of heart donors, new solutions ...
Tópico(s): 3D Printing in Biomedical Research
2018 - Wiley | Advanced Healthcare Materials
Nadia Ramírez, M. Arias Rodríguez, Marta Ayala, José A. Cremata, Marlene Pérez, Anazuria Martínez, Marbelis Linares, Yasser Hevia, Rolando Páez, Rodolfo Valdés, Jorge Gavilondo, Guillermo Selman‐Housein,
Transgenic plants expressing recombinant immunoglobulins have arisen as an alternative technology for the large-scale production of antibodies useful in therapeutics and in industrial processes. In the present paper we report the expression in transgenic tobacco ( Nicotiana tabacum ) of an anti-HBsAg [anti-(hepatitis B virus surface antigen)] mouse IgG1 mAb (monoclonal antibody), currently used for the industrial purification of the recombinant vaccine antigen. Using the sweet potato sporamin signal peptide, ...
Tópico(s): Toxin Mechanisms and Immunotoxins
2003 - Wiley | Biotechnology and Applied Biochemistry
Víctor A. Sosa‐Hernández, Jiram Torres‐Ruiz, Rodrigo Cervantes‐Díaz, Sandra Romero‐Ramírez, José C. Páez-Franco, David Eduardo Meza-Sánchez, Guillermo Juárez‐Vega, Alfredo Pérez‐Fragoso, Vianney Ortiz‐Navarrete, Alfredo Ponce‐de‐León, Luis Enrique Montiel Llorente, Laura Berrón‐Ruiz, Nancy R. Mejía‐Domínguez, Diana Gómez-Martı́n, José Luis Maravillas‐Montero,
Background SARS-CoV-2 infection represents a global health problem that has affected millions of people. The fine host immune response and its association with the disease course have not yet been fully elucidated. Consequently, we analyze circulating B cell subsets and their possible relationship with COVID-19 features and severity. Methods Using a multiparametric flow cytometric approach, we determined B cell subsets frequencies from 52 COVID-19 patients, grouped them by hierarchical cluster analysis, ...
Tópico(s): Long-Term Effects of COVID-19
2020 - Frontiers Media | Frontiers in Immunology
Lecia V. Sequist, Ronald B. Natale, Neil Senzer, R. G. Martins, Rogério Lilenbaum, Jhanelle E. Gray, Darrell R. Borger, Guillermo Paez, David Grayzel, Scott Gettinger,
7517 Background: Oncogenic ALK gene rearrangements (rALK) recently have been identified in approximately 3-5% of all NSCLC, particularly in non-smoking patients (pts) with epidermal growth factor receptor (EGFR) wild-type tumors. IPI-504 is a potent, water-soluble heat shock protein 90 (Hsp90) inhibitor that is being evaluated in a clinical study of patients with NSCLC, stratified by EGFR status. In preclinical models, ALK is a client protein of the Hsp90 chaperone; therefore, a retrospective analysis ...
Tópico(s): Cancer Treatment and Pharmacology
2010 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Marcelo Páez-Pereda, Victoria Goldberg, Alberto Chervín, Guillermo Carrizo, A. Molina, Jerrian Joyce Andrada, Joachim Sauer, Ulrich Renner, Günter K. Stalla, Eduardo Arzt,
We have previously shown that interleukin-2 (IL-2) and IL-6, which are expressed in the anterior pituitary, affect anterior pituitary cell proliferation in normal rats and cell lines. Here we examined their effects on the c-fos expression by human anterior pituitary adenomas. Adenoma cells in culture do not express c-fos mRNA. In adenoma explants, however, c-fos expression was detected and was regulated by IL-2 or IL-6. In different tumors (ACTH-, PRL-, GH-secreting and non functioning adenomas), ...
Tópico(s): Cancer, Hypoxia, and Metabolism
1996 - Elsevier BV | Molecular and Cellular Endocrinology
Carolina Perez Castro, Alberto Carbia Nagashima, Marcelo Páez-Pereda, Victoria Goldberg, Alberto Chervín, Guillermo Carrizo, Helen Molina, Ulrich Renner, GK Stalla, Eduardo Arzt,
Two of the most potent cytokines regulating anterior pituitary cell function are leukemia inhibitory factor (LIF) and interleukin (IL)-6, which belong to the cytokine family using the common gp130 signal transducer. Recently, the expression and action of two other members of this family, IL-11 and ciliary neurotrophic factor (CNTF), on different cell lines has also been demonstrated. We studied the expression of the specific receptor subunits for CNTF in mammotropic, non-functioning and somatotropic ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2001 - Bioscientifica | Journal of Endocrinology