Alan Tomlinson, Steve Acteson Dubai, Phlip Ray, Jeremy Andrews, Jon Ashworth, Victoria Glendinning, Alban Morgan, General Secretary, Dennis Kavanagh Professor of Politics, James Clappison, Clifford Longley, P. G., Patricia Davies, Jane MacQuitty, Simon Barnes, Jasper Rees, T. G. Palferman, Neil Bennett, Steve Hocking, Ronald Faux, Sheila Gunn and Richard Ford, Martin Spence, David Lee, Cliff Feltham, Tom Pocock, Tim Congdon Economic adviser, Timothy Garton Ash, Angela MacKay, Michael Stevenson, Philip Howard, Andrei Navrozov, Cosmo Hawkes, Michael Binyon, Jeremy Kingston, Sheila Guna, Political Reporter, Clive Davis, Jeremy Flint, Richard Eaton, J. F. Q. Switzer, Roddy Forsyth, John Marks (Chairman of Council), Colin Narbrough, Gerald Davies, Michael Seely Racing Correspondent, Joe Joseph, Dinah Birch, Francesca Greenoak, Martin Fletcher, Bryan Stiles, Stephen Warr, James Molyneaux, Leader, Ian Murray and David Sapsted, Alan Lorimer, Ruth Gledhill, Nigel Williamson Political Staff, Michael Knipe, Louise Taylor, Vincent Duggleby, Martin Andrew, Nick Nuttall Technology Correspondent, Peter Waymark, Charles Jackson, Peter Bills, Mitchaell Platts Golf Correspondent Sotogrande, Robin Young, Martin Cropper, Brian Morton, Robert Nye, Michael Clark, Thomson Prentice, Science Correspondent, Philip Robinson, Lawrie Smith, Frances Bissell, Charles Bremner, Geoffrey Matthews, Simon Tait, John Ardagh, Oscar Moore, Nicole Swengley, Gavin Bell, Richard Thomson and Michael Clark, Sydney Friskin, Hamish Lennox, Nicholas Harling, Jill Insley, Gillian Bowditch, William Hobson, (Michael Phillips), J. A., Richard Davy, Brian Collet, John Higgins, Michael Watkins, Francis Van den Eynde, Kerry Gill, Raymond Keene, John Ashworth, Peter Davalle, Paul Griffiths, Ray Connolly, Andrew McEwen, Diplomatic Correspondent, Peter Bryan, Iona Opie and Moira Tatem, Richard Evans, Stuart Weir, Editor, Conrad Voss Bark, Simon James Alderson, Martin Trew, Richard Evans Media Editor, Barry Pickthall, Robin Oakley, Philip Webster, Rodney Lord and Richard Ford, Gillian Bowditch and Philip Robinson, Sheila Gunn Political Reporter, Richard Bassett, Derek Harris, Industrial Editor, Keith MacKlin, Charles Knevitt, Architecture Correspondent, Rodney Hobson, David Hands Rugby Correspondent, Kenneth Fleet, Christopher Thomas, Pat Butcher, Athletics Correspondent, John England, Peter Thompson, Philip Webster Chief Political Correspondent, Christopher Walker, Colin Wilson, George Hill, Andrew Stuart, President, Clive White, Matthew Parris, David Icke, Paul Newman, Sarah Jane Checkland Art Market Correspondent, Freda Craven, Frances Edmonds, John Shaw, Philip Jacobson and Harry Debelius, Peter Morris, Jenny Gilbert, Corinne Schmidt, Santa Lucia, Graham Searjeant, Melinda Wittstock, Philip Pangalos, Tom Tickell, Michael Horsnell, Charles Hennessy, Jim Hiley, Quentin Cowdry, Home Affairs Correspondent, Jonathan Meades, Simon Rose, Richard Morrison, Derek Harris Industrial Editor, Rosamond Hanworth, President, Richard Ford, Political Correspondent, Harvey Elliott Air Correspondent, Tony Hetherington, Conal Gregory, Judy Froshaug, Tim Jones, Employment Affairs Correspondent, Philip Jacobson, Ray Whitney, Andrew Longmore, Tennis Correspondent, Mary Dejevsky, David Ashton, Philip Ray, Andrew McEwen, James Bone and Christopher Follett,
'Business as usual' with markets calm Thatcher moves to steady party nerves despite leadership fears Portfolio Platinum In today's 64-page Times Major ' ...
1989 - Gale Group | TDA
... 1 it comes from the cosmogony of the Guna population, an Indigenous nation in the region of Guna Yala (or the land of the Guna), formally known as San Blas in present-day Panama.2 Abiayala in the Guna language means "land in full maturity" or "saved territory" (Aiban Wagua, 342). According to Guna cosmogony, up to the present, four historical stages ... 342). Abiayala is also the name that the Guna use to refer to what for others is ... in Panama. He heard about the conflict between Guna authorities and the American investor Thomas M. Moody, ...
Tópico(s): Latin American Cultural Politics
2018 - University of Minnesota Press | Native American and Indigenous Studies
Valerie Riches, Frances Gibb, Legal Affairs Correspondent, Lucy Hodges, Education Correspondent, Peter Evans Home Affairs Correspondent, Clifford Longley, Alan Gibson, Keith Dalton, Peter Marson, Simon Barnes, Tim Paine, Ronald Faux, Cliff Feltham, Ivo Tennant, Bryan Ewing, Hilary Finch, Bryan Thwaites, Hasan Akhtar, Richard Streeton, John Best, Mario Modiano, Geoffrey Smith, S. P., Robert Spencer, Mitchell Platts, Jim Railton, Anne Sofer, Alan Toogood Horticulture Correspondent, Peter Ball, Michael Brucciani, Clifford Longley, Religious Affairs Correspondent, Gavin Stamp, Chairman, Elizabeth Crabb, Lawrence Lever, Alan Hamilton, Martin Cropper, Adrian Taylor, Thomson Prentice, Science Correspondent, Marcus Williams, Angella Johnson and Alan Wood, Hugh Clayton, Environment Correspondent, Rex Bellamy, Peter Barnard, Rex Bellamy, Tennis Correspondent, John Hennessy, Geoffrey Matthews, John Young, Agriculture Correspondent, Thomson Prentice, Sheila Guna, Political Staff, Dick Hinder, Angella Johnson, Rex Bellamy Tennis Correspondent, Philip Webster, Chief Political Correspondent, Celia Brayfield, David Watts, Mark Dowd, Clare Dobie, Michael Baily, Transport Editor, Alison Eadie, Peter Davalle, Nicholas Beeston, Christopher Duggan, Paul Griffiths, Charles Harrison, Jonathan Braude, Kuldip Nayar, Patricia Clough, Heather Kirby, Craig Seton, PHS, John Blunsden, Joyce Whitehead, Maxwell Newton, Michael Scott, Derek Richards, Edward Townsend Industrial Correspondent, Kenneth Fleet, Pat Butcher, Athletics Correspondent, Christopher Walker, Richard Coghlan, George Hill, John Wilcockson, P. J. Korshin, Mike Berry, M. G. G. Pillai, and Philip Webster, Neil Harris, Michael Hornsby, A. N. Author, Martin Rewcastle, Peter Dear and Peter Davalle, Lake Sagaris, David Sinclair, Stephen Pettitt, Tim Jones, John Woodcock, Cricket Correspondent, Jill Spencer, Frances Gibb Legal Affairs Correspondent, R. T. Rivington, Nicholas Wood, Political Reporter, Bill Johnstone, Technology Correspondent, John Carlin, Cludad Juarez, Robert Fisk, Richard Morrison, John Rashley, Richard Lander, Andrew Phillips, Susan MacDonald, Penny Perrick, Isabel Unsworth, Michael Coleman, Richard Ford, Peter Evans, Home Affairs Correspondent, Richard Wigg, Richard Williams, John Watson,
Thatcher plea fails to halt hanging Graduation daze Tomorrow Portfolio gold On This Day Bristol passes Index Pope visits 'cemetery' that was Armero Third ...
1986 - Gale Group | TDA
Catarina J Gaspar, Ligia Vieira, Cristiana C. Santos, John C. Christianson, Dávid Jakubec, Kvido Střı́šovský, Colin Adrain, Pedro Domingos,
... the Sec61 translocon, where membrane insertion takes place (Guna & Hegde, 2018). The co-translational insertion pathway is ... Wang et al, 2010; Rao et al, 2016; Guna et al, 2018). Recently, the ER membrane protein ... proteins with TMDs of moderate to low hydrophobicity (Guna et al, 2018; Tian et al, 2019; Volkmar ... proteins with TMDs of moderate to low hydrophobicity (Guna et al, 2018), but the identities of its ... most predicted TA proteins (~67%) exhibited low hydrophobicity (Guna et al, 2018) (hydrophobicity value below 22 in ...
Tópico(s): Genetics, Aging, and Longevity in Model Organisms
2021 - Springer Nature | EMBO Reports
Frances Gibb, Legal Affairs Correspondent, Juan Carlos Gumucio, Chris Petit, Adrian Room, Holly Hill, Peter Garfiand, Peter Marson, Ion Ratiu, Geraldine Norman, Sale Room Correspondent, Ivo Tennant, Ferdinand Mount, Joan Llewelyn Owens, Hilary Finch, Ian Murray, Michael Binyon, John Clench, Noel Goodwin, L. R. Lewis, Stuart Jones Football Correspondent, John Clare, Education Correspondent, Caroline Moorehead, Jim Railton, Stephen Bayl's, Harry Golombek, Michael Tate, Rodney Lord, Michael Hornsby, Johannesburg, Lawrence Lever, Peter Ackroyd, David Smith Ecomics Correspondent, Martin Cropper, Jenny MacArthur, Michael Clark, Thomson Prentice, Science Correspondent, Peter Dear and Christopher Davalle, John Young, Michael Hamlyn, Diana Geddes, Gloria Steinem, Fred Smithies, Richard Evans, Political Correspondent, G. A. Wilkinson, John Young, Agriculture Correspondent, Martin Fletcher Political Reporter, Sydney Friskin, Nicholas Harling, Ann Warden, D. A. Brown, Chris Thau, David Miller, Philip Webster, Chief Political Correspondent, (Michael Phillips), John Higgins, Christopher Goulding, Hurry Debelius, Gareth Huw Davies, Paola Pelagatti, Brigid Brophy, Michael Binyon Washington, Paul Griffiths, Mark Dowd, Education Reporter, Sheila Guna Political Staff, Liz Gill, Richard Evans, Conrad Voss Bark, Robert Matthews, Craig Seton, Carol leonard, Gavin Bell, Arts Correspondent, Richard Owen, Ronald Butt, Daphen Park, Johansson, Keith MacKlin, Mohsin Ali Washington, Murtin Fletcher Political Reporter, Ian Smith, Christopher Walker, Edward Townsend, Industrial Correspondent, George Hill, Michael Rezendes, Teresa Poople Business Correspondent, Clive White, Keith Dalton Manila, Robert Grieves, Tim Jones, George Chesterton, Michael Evans Defence Corrdespondent, Christopher Follett, Christopher Warman, Nicholas Wood, Political Reporter, Charles Forte, Michael Evans Defence Correspondent, Kenneth Zucker, Pat Butcher Athletics Correspondent, Hugh Taylor, Peter Moss, Bill Cotton, David Sapsted and John Goodbody, David Hands, Rugby Correspondent, Michael Coleman, Richard Ford, Colin McQuillan, Richard Wigg,
Election hint as Ridley cuts privatization Eurotunnel man for Guinness Fraud inquiry Racing view Better links Portfolio Index Candidates' guide ready ...
1987 - Gale Group | TDA
Zahrul Atharinafi, Nurrohman Wijaya,
... under existing land use planning policy.Abstrak. Perubahan guna lahan pada wilayah hulu diketahui sebagai salah satu ... kawasan metropolitan diketahui sebagai faktor pendorong terjadinya perubahan guna lahan. Berdasarkan kondisi tersebut, kami melakukan studi terhadap pola perubahan guna lahan pada Sub-DAS Cirasea, pada 20 tahun ... waktu yang sama. Paper ini meneliti bagaimana perubahan guna lahan pada wilayah pinggiran Metropolitan Bandung Raya mempengaruhi ... kurva. Berdasarkan hasil studi, diketahui telah terjadi perubahan guna lahan yang signifikan pada wilayah hulu DAS. Hutan ...
Tópico(s): Coastal Management and Development
2021 - Bandung Institute of Technology | Journal of Regional and City Planning
Dimelza Araúz, Luis De Urriola, José Jones, Marlene Castillo, Alexander A. Martínez, E S Róger Murillo, Leonidas Troncoso, María Chen-Germán, Leyda Ábrego, Blas Armién, Juan Miguel Pascale, Néstor Sosa, Sandra López‐Vergès, Brechla Moreno,
... or chikungunya virus; these illnesses occurred in the Guna Yala region of eastern Panama, which borders northern Colombia (Figure). Figure Locations in the Guna Yala region of eastern Panama with confirmed cases ... January 22, 2016. Inset maps show locations of Guna Yala in Panama and of Panama in the ... 276 patients who sought care at clinics in Guna Yala during November 27, 2015–January 22, 2016, ... following up with known pregnant women of the Guna Yala region who report Zika virus infection symptoms ... positive predictive value for detecting microcephaly (9). In Guna Yala, no symptoms of Guillain-Barre syndrome or ...
Tópico(s): Dengue and Mosquito Control Research
2016 - Centers for Disease Control and Prevention | Emerging infectious diseases
Lisbeth Hurtado, José E. Calzada, Chystrie Rigg, Milagros Castillo, Luis Fernando Chaves,
... Niño Southern Oscillation (ENSO). Monthly malaria cases in Guna Yala (1998–2016) were autocorrelated up to 2 ... of Anopheles albimanus, the main malaria vector in Guna Yala. Interannual cycles, of approximately 4-year periods, ... index associated with weather and vegetation dynamics in Guna Yala at seasonal and interannual time scales. The ... associated with the number of malaria cases in Guna Yala during the study period. These results highlight the vulnerability of Guna populations to malaria, an infection sensitive to climate ...
Tópico(s): Viral Infections and Vectors
2018 - BioMed Central | Malaria Journal
Lorenzo Cáceres, José E. Calzada, Amanda Gabster, Josué Young, Ricardo Márquez, Rolando Torres, Margarita Griffith,
... was to recognize the social representation of the Guna indigenous population by identifying cultural elements related to ... classification and categorization of interviews.Malaria within the Guna culture is in harmony with several cultural factors, ... measures. Until this is not properly addressed, the Guna population of Madungandi will remain a permanent source ... of malaria in the indigenous population of Comarca Guna de Madungandi, Panama.
Tópico(s): Public Health and Social Inequalities
2017 - BioMed Central | Malaria Journal
Margarita Griffith, José Rovira, Rolando Torres, José E. Calzada, Carlos Victoria, Lorenzo Cáceres,
... not the transmission of malaria in the indigenous Guna population of Madungandí.A cross-sectional study was ... in three communities with high malaria incidence. Local Guna residents and translators were part of the research ... belonged to and spoke the language of the Guna ethnic group, 64% were male and 30% were ... as the willingness to collaborate shown by the Guna population, it is essential to initiate educational and ...
Tópico(s): Child Nutrition and Water Access
2015 - National Institute of Health | Biomédica
José E. Calzada, Ricardo Márquez, Chystrie Rigg, Carlos Victoria, Manuel de la Cruz, Luis Fernando Chaves, Lorenzo Cáceres,
... in 2012 in a socially marginalized population from Guna Yala Comarca in Panama. A descriptive and observational ... malaria cases registered during 2012 in the Comarca Guna Yala, Panama. Malaria intensity indicators were calculated during ... 8/1000, SPR: 2.1 %) was observed in Guna Yula, when compared with previous years, and also ... that during 2012 a malaria epidemic occurred in Guna Yala. Panama. This study provides baseline data on ...
Tópico(s): Travel-related health issues
2015 - BioMed Central | Malaria Journal
ShamGanpat Tikhe, HR Nagendra, Neeraj Tripathi,
... The objective of this study was to assess Guna (personality traits) in students undergoing Yoga Instructor's ... 11.33% decrease (P < 0.01) in Tamas Guna (dull personality trait), 0.68% decrease (P =0.819) in Rajas Guna (violent personality trait), and 10.34% increase (P <0.01) in Sattva Guna (balanced personality trait) scores.This study suggests that YIC can result in the improvement of Sattva Guna (balance personality trait) among students, thus paving the ...
Tópico(s): Mindfulness and Compassion Interventions
2012 - Medknow | Ancient Science of Life
... organizations, Kaur and Sinha identify four factors — Tamas Guna, Rajas Positive Guna, Sattwa Guna, and Rajas Negative Guna and discuss the relationship of these variables with ...
Tópico(s): Business Strategies and Management Research
1992 - SAGE Publishing | Vikalpa The Journal for Decision Makers
Mario I. Ávila, Élodie A. Vajda, Eileen Jeffrey Gutiérrez, Daragh A. Gibson, Mariela Mosquera Renteria, Nicholas A. Presley, Daniel O’Reilly, Timothy A. Burton, Allison Tatarsky, Neil F. Lobo,
... localized foci of transmission persist, including in the Guna Yala region. Government-led entomological surveillance using an ... in the communities of Permé and Puerto Obaldía, Guna Yala, as well as to pinpoint any remaining ... to the drivers of persisting malaria transmission in Guna Yala. These findings highlight the need for continued ...
Tópico(s): Insect Resistance and Genetics
2021 - BioMed Central | Malaria Journal
Adugnaw Birhanu, Enyew Adgo, Amaury Frankl, Kristine Walraevens, Jan Nyssen,
... and its drivers at varying scale in Mt. Guna. The recent land cover map was generated from ... varying scale. The change analysis revealed that Mt. Guna showed a dynamic land cover change between 1957 ... while 31% of the land cover of Mt. Guna showed persistence over 61 years. Furthermore, 77% of ...
Tópico(s): Conservation, Biodiversity, and Resource Management
2021 - Wiley | Land Degradation and Development
Abdulkadir Rahardjanto, N. Nurwidodo, Mas’odi Mas’odi,
... masyarakat, sebagai hasil introduksi pengetahuan dan teknoligi tepat guna (TTG) sangat diperlukan. Artikel ini bertujuan menganalisis implementasi pemanfaatan teknologi tepat guna berbasis solar cell untuk mengatasi permasalahan IRT Ramuan ... Ramuan Madura, ramuan tradisional, Kabupaten Sumenep, teknologi tepat guna
Tópico(s): Blockchain Technology in Education and Learning
2019 - | International Journal of Community Service Learning
Lisbeth Hurtado, Chystrie Rigg, Igor Calzada, Sahir R. Dutary, Damaris Bernal, Susana Koo, Luis Fernando Chaves,
... from May 2016 to December 2017 in Ipetí-Guna, a village within an area targeted for malaria ... between January and April from environments associated with Guna population's daily activities, which suggests this time ... campaigns aimed at clearing Plasmodium spp. parasites from Guna populations using, for example, mass drug administration.
Tópico(s): Viral Infections and Vectors
2018 - Multidisciplinary Digital Publishing Institute | Insects
Soeparno Djiwo, Eko Yohanes Setyawan,
... di tingkatkan lagi melalui pengolahan dengan teknologi tepat guna hingga menjadi kualitas ekspor. Hasil analisa m enunjukkan bahwa d engan menggunakan mesin teknologi tepat guna dapat meminimalisir waktu proses produksi yang sebelumnya membutuhkan ... kali proses. Sehingga dengan adanya mesin teknologi tepat guna dapat meningkatkan produktivitas sabut kelapa. Dalam proses menggunakan ...
2016 - The MIT Press | Kagoshima Kenritsu Tanki Daigaku Chiiki Kenkyūjo kenkyū nenpō
... long-term anthropological fieldwork with members of the Guna communities of Panama, undertaken between 2003 and 2013, ... responsible way of producing tourism, exemplified by the Guna case. The Guna sustainable tourism model is an illuminating example of ...
Tópico(s): Cruise Tourism Development and Management
2016 - Taylor & Francis | Journal of Sustainable Tourism
... head and Professor in ECE department at JUET, Guna. Professor Saxena has supervised thirteen Ph.D. candidates ... from Jaypee University of Engineering and Technology (JUET), Guna under the guidance of Professor Rajiv Saxena in ... MPCT, Gwalior. In July, 2006, he joined JIET Guna, which became JUET in 2010, as a Lecturer ... he worked as an Assistant Professor in JUET, Guna. Currently, he is working as an Assistant Professor ...
Tópico(s): graph theory and CDMA systems
2013 - Taylor & Francis | IETE Journal of Education
Ajaya R. Shrestha, Yutaro Kotobuki, Yoshiyuki Hari, Satoshi Obika,
... by guanidine, termed as guanidine bridged nucleic acid (GuNA), was synthesized and incorporated into oligonucleotides. Thermal stabilities and nuclease resistance of GuNA-modified oligonucleotides were investigated and compared with those ... 2',4'-BNA/LNA and natural DNA oligonucleotides. GuNA exhibited interestingly high binding affinity towards complementary ssDNA ...
Tópico(s): RNA Interference and Gene Delivery
2013 - Royal Society of Chemistry | Chemical Communications
Gunasegaran Karupiah, Geeta Chaudhri,
... 398-399 Book Review IMMUNOLOGY OF INFECTIOUS DISEASES Guna Karupiah, Guna Karupiah Infection and Immunity Group, Division of Immunology & ... ACT, AustraliaSearch for more papers by this author Guna Karupiah, Guna Karupiah Infection and Immunity Group, Division of Immunology & ...
Tópico(s): Brucella: diagnosis, epidemiology, treatment
2002 - Wiley | Immunology and Cell Biology
... theory that is immensely popular in management literature. Guna Dynamics is an Indian psycho-philosophical theory of ... of years. Yet, rigorous study and application of Guna theory to management is grossly neglected. S K ... similarities and differences between them. He finds that Guna theory is more comprehensive in its scope than ...
Tópico(s): Transactional Analysis in Psychotherapy
1988 - SAGE Publishing | Vikalpa The Journal for Decision Makers
Mario I. Ávila, Élodie A. Vajda, Eileen Jeffrey Gutiérrez, Daragh A. Gibson, Mariela Mosquera Renteria, Nicolas Presley, Daniel O’Reilly, Allison Tatarsky, Neil F. Lobo,
... localized foci of transmission persist, including in the Guna Yala region. Government-led entomological surveillance using an ... in the communities of Permé and Puerto Obaldía, Guna Yala. Adult Anopheles were sampled at three time ... social behaviour change communication (SBCC) strategy in the Guna Yala Comarca (Jul 2019), which increased LLIN use. ...
Tópico(s): Viral Infections and Vectors
2023 - BioMed Central | Malaria Journal
Malcolm Innes-Brown, Samir Chatterjee,
The relevance of the guna theory to applications of Western management practice is seen in this paper as an insight holding capacity to guide managerial behaviour. In its essence, the guna theory depicts values which constitute human personality into ... managerial action in the West. As such, the guna theory has deep relevance in the face of ...
Tópico(s): Ethics in Business and Education
1999 - SAGE Publishing | Journal of Human Values
P.N. Ravindra, Prashanth Babu,
... to organizational behavior. Indian psychological principles of Tri-Guna offer a universal theoretical framework to understand the ... circuits underlying few universal emotional styles. Both Tri-Guna and emotional styles are dynamic and vulnerable for ... with training. Hence, establishing a relation between Tri-Guna and emotional style offers a novel insight to explore neural basis of Tri-Guna and its application in health and behavioral sciences.To establish the correlation between Tri-Guna and emotional styles in healthy adult subjects.Healthy ...
Tópico(s): Heart Rate Variability and Autonomic Control
2021 - Medknow | International Journal of Yoga
Hemant Bhargav, Najla Eiman, Nishitha Jasti, Pooja More, Vinod Jangir Kumar, Bharath Holla, Rashmi Arasappa, Naren P. Rao, Shivarama Varambally, Bangalore N. Gangadhar, Matcheri S. Keshavan,
Yoga philosophy includes the theory of Tri-guna (three mental traits): sattva (signifies a tendency to ‘goodness’), rajas (tendency towards ‘activity’), and tamas (tendency towards “inertia”). This cross-sectional study aimed ... MANOVA) was used to assess the differences in guna scores between HCs and patients, and between patients ... OCD). Each psychiatric diagnosis also showed a specific guna configuration: (1) Anxiety disorders and OCD: High sattva- ...
Tópico(s): Mindfulness and Compassion Interventions
2023 - Frontiers Media | Frontiers in Psychology
Takashi Sasaki, Yoko Hirakawa, Fumiko Yamairi, Takashi Kurita, Karin Murahashi, Hirokazu Nishimura, Norihiko Iwazaki, Hidenori Yasuhara, Takashi Tateoka, Tetsuya Ohta, Satoshi Obika, Jun Kotera,
Guanidine-bridged nucleic acid (GuNA) is a novel 2′,4′-bridged nucleic acid/locked nucleic acid (2′,4′-BNA/LNA) analog containing cations that exhibit ... In this study, Malat1 antisense oligonucleotide (ASO) bearing GuNA was evaluated for target knockdown (KD) activity and tolerability. The GuNA ASO did not interfere with RNase H recruitment ... observed in a hepatocyte-derived cell line. The GuNA ASO exhibited potent KD activity in various tissues; ... In addition, despite the higher accumulation of the GuNA ASO in the liver, levels of aspartate aminotransferase ...
Tópico(s): Advanced biosensing and bioanalysis techniques
2022 - Mary Ann Liebert, Inc. | Nucleic Acid Therapeutics
Tatek Belay, Tadele Melese, Abebe Senamaw,
... services values in the afro-alpine area of Guna Mountain, Northwestern Ethiopia. Image classification was carried out ... of LULCC in the afro-alpine area of Guna Mountain was the expansion of cropland and built- ...
Tópico(s): Soil and Land Suitability Analysis
2022 - Elsevier BV | Heliyon
Shinji Kumagai, Hiroaki Sawamoto, Tomo Takegawa-Araki, Yuuki Arai, Shuhei Yamakoshi, Katsuya Yamada, Tetsuya Ohta, Eiji Kawanishi, Naohiro Horie, Takao Yamaguchi, Satoshi Obika,
Facile synthesis of GuNA (guanidine-bridged nucleic acid) phosphoramidites bearing thymine, adenine, guanine, and 5-methylcytosine nucleobases and a robust method for the preparation of GuNA-modified oligonucleotides are described.
Tópico(s): RNA Interference and Gene Delivery
2020 - Royal Society of Chemistry | Organic & Biomolecular Chemistry