Christie M. Ballantyne, Puja Banka, Gustavo Méndez, Raymundo Garcia, Julio Rosenstock, Anthony Rodgers, Geraldine Mendizabal, Yale Mitchel, Alberico L. Catapano,
MK-0616 is an oral macrocyclic peptide inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9) in development for the treatment of hypercholesterolemia.This Phase 2b, randomized, double-blind, placebo-controlled, multicenter trial aimed to evaluate the efficacy and safety of MK-0616 in participants with hypercholesterolemia.This trial was planned to include 375 adult participants with a wide range of atherosclerotic cardiovascular disease risk. Participants were assigned randomly (1:1:1: ...
Tópico(s): Health Systems, Economic Evaluations, Quality of Life
2023 - Elsevier BV | Journal of the American College of Cardiology
Margarita Brovetto, Daniela Gamenara, Patricia Saenz‐Méndez, Gustavo Seoane,
... in Organic SynthesisMargarita Brovetto†, Daniela Gamenara†, Patricia Saenz Méndez†‡, and Gustavo A. Seoane*†View Author Information† †Grupo de Fisicoquímica ...
Tópico(s): Cyclopropane Reaction Mechanisms
2011 - American Chemical Society | Chemical Reviews
V. E. Soroa, Mańa del Huerto Velázquez Espeche, Carlos Giannone, Horacio Caviglia, Gustavo Galatros, Daniel Fernández, Marcos Méndez, Gustavo Guillermo Naswetter, Jorge Nicolini,
The aim of this study was to assess the effects of treatment with our locally produced P-32 colloidal suspension on knee synovitic inflammations of hemophilic and rheumatoid arthritis (RA) patients, as well as to compare results with chemical synovectomy or corticoid intra-articular injections and evaluate the cost-benefit ratio.Thirty-six hemophilic male patients, 4-28 years of age and sent by the Hemophilic Foundation (Buenos Aires, Argentina), were enrolled for knee radiosynovectomy (RS) with P- ...
Tópico(s): Orthopedic Infections and Treatments
2005 - Mary Ann Liebert, Inc. | Cancer Biotherapy and Radiopharmaceuticals
Francesco Marchesi, Jon Salmanton‐García, Caterina Buquicchio, Federico Itri, Caroline Besson, Julio Dávila, Sonia Martín‐Pérez, Luana Fianchi, Laman Rahimli, Giuseppe Tarantini, Federica Irene Grifoni, Mariarita Sciumè, Jorge Labrador, Raúl Córdoba, Alberto López‐García, Nicola Fracchiolla, Francesca Farina, Emanuele Ammatuna, A. Cingolani, Daniel García-Bordallo, Stefanie K. Gräfe, Yavuz M. Bilgin, Michelina Dargenio, Tomás José González‐López, Anna Guidetti, Tobias Lahmer, Esperanza Lavilla, Gustavo‐Adolfo Méndez, Lucia Prezioso, Martin Schönlein, Jaap A. van Doesum, Dominik Wolf, Ditte Stampe Hersby, Ferenc Magyari, Jens Van Praet, Verena Petzer, Carlo Tascini, Iker Falces‐Romero, Andreas Glenthøj, Oliver A. Cornely, Livio Pagano,
Abstract Only few studies have analyzed the efficacy of tixagevimab/cilgavimab to prevent severe Coronavirus disease 2019 (COVID-19) and related complications in hematologic malignancies (HM) patients. Here, we report cases of breakthrough COVID-19 after prophylactic tixagevimab/cilgavimab from the EPICOVIDEHA registry). We identified 47 patients that had received prophylaxis with tixagevimab/cilgavimab in the EPICOVIDEHA registry. Lymphoproliferative disorders (44/47, 93.6%) were the main underlying ...
Tópico(s): Cancer Immunotherapy and Biomarkers
2023 - BioMed Central | Journal of Hematology & Oncology
Produção Nacional
Revisado por pares
Jon Salmanton‐García, Francesco Marchesi, María Gomes da Silva, Francesca Farina, Julio Dávila, Yavuz M. Bilgin, Andreas Glenthøj, Iker Falces‐Romero, Jaap A. van Doesum, Jorge Labrador, Caterina Buquicchio, Shaimaa El‐Ashwah, Verena Petzer, Jens Van Praet, Martin Schönlein, Michelina Dargenio, Gustavo‐Adolfo Méndez, Stef Meers, Federico Itri, Antonio Giordano, László Imre Pinczés, Ildefonso Espigado, Zlate Stojanoski, Alberto López‐García, Lucia Prezioso, Ozren Jakšić, Antonio Vena, Nicola Fracchiolla, Tomás José González‐López, Nataša Čolović, Mario Delia, Barbora Weinbergerová, Monia Marchetti, Joyce Marques de Almeida, Olimpia Finizio, Caroline Besson, Monika Biernat, Toni Valković, Tobias Lahmer, Annarosa Cuccaro, Irati Ormazabal‐Vélez, Josip Batinić, Noemí Fernández, Nick de Jonge, Carlo Tascini, Amalia Anastasopoulou, Rémy Duléry, Maria Ilaria Del Principe, Gaëtan Plantefève, Mario Virgilio Papa, Márcio Nucci, Moraima Jiménez, Avinash Aujayeb, José‐Ángel Hernández‐Rivas, Maria Merelli, Chiara Cattaneo, Ola Blennow, Anna Nordlander, Alba Cabirta, Gina Varricchio, Maria Vittoria Sacchi, Raúl Córdoba, Elena Arellano, Stefanie K. Gräfe, Dominik Wolf, Ziad Emarah, Emanuele Ammatuna, Ditte Stampe Hersby, Sonia Martín‐Pérez, Raquel Nunes Rodrigues, Laman Rahimli, Livio Pagano, Oliver A. Cornely, Klára Piukovics, Cristina De Ramón, François Danion, Ayel Yahya, Anna Guidetti, Carolina García‐Vidal, Uluhan Sili, Joseph Meletiadis, Elizabeth de Kort, Luisa Verga, Laura Rubio i Serrano, Nurettin Erben, Roberta Di Blasi, Athanasios Tragiannidis, José-María Ribera-Santa Susana, Hans Beier Ommen, Alessandro Busca, Nicola Coppola, Rui Bergantim, Giulia Dragonetti, Marianna Criscuolo, Luana Fianchi, Matteo Bonanni, Andrés Soto, Małgorzata Mikulska, Marina Machado, Chi Shan Kho, Nazia Hassan, Eleni Gavriilaki, Gregorio Cordini, Louis Yi Ann, Matthias Eggerer, Martin Hoenigl, Juergen Prattes, María-Josefa Jiménez-Lorenzo, Sofia Zompi, Giovanni Paolo Maria Zambrotta, Gökçe Melis Çolak, Nicole García‐Poutón, Tommaso Francesco Aiello, Romane Prin, Maria Stamouli, Michail Samarkos,
Nirmatrelvir/ritonavir treatment decreases the hospitalisation rate in immunocompetent patients with COVID-19, but data on efficacy in patients with haematological malignancy are scarce. Here, we describe the outcome of nirmatrelvir/ritonavir treatment in a large cohort of the latter patients.This is a retrospective cohort study from the multicentre EPICOVIDEHA registry (NCT04733729) on patients with haematological malignancy, who were diagnosed with COVID-19 between January and September 2022. Patients ...
Tópico(s): Long-Term Effects of COVID-19
2023 - Elsevier BV | EClinicalMedicine
Mohamed M. Salem, Okkes Kuybu, Alex Nguyen Hoang, Ammad A. Baig, MirHojjat Khorasanizadeh, Cordell M. Baker, Joshua C. Hunsaker, Aldo A. Mendez, Gustavo M Cortez, Jason M. Davies, Sandra Narayanan, C. Michael Cawley, Howard A. Riina, Justin M. Moore, Alejandro M Spiotta, Alexander A. Khalessi, Brian M. Howard, Ricardó A. Hanel, Omar Tanweer, Elad I. Levy, Ramesh Grandhi, Michael J. Lang, Adnan H. Siddiqui, Peter Kan, Christopher S. Ogilvy, Bradley A. Gross, Ajith J. Thomas, Brian T. Jankowitz, Jan‐Karl Burkhardt,
Background Knowledge regarding predictors of clinical and radiographic failures of middle meningeal artery (MMA) embolization (MMAE) treatment for chronic subdural hematoma (CSDH) is limited. Purpose To identify predictors of MMAE treatment failure for CSDH. Materials and Methods In this retrospective study, consecutive patients who underwent MMAE for CSDH from February 2018 to April 2022 at 13 U.S. centers were included. Clinical failure was defined as hematoma reaccumulation and/or neurologic deterioration ...
Tópico(s): Spinal Hematomas and Complications
2023 - Radiological Society of North America | Radiology
Rosaura González-Méndez, Gustavo Ramı́rez, Sherry Hamby,
Some negative experiences during adolescence can jeopardize psychological adaptation throughout life. Therefore, promoting adolescent resilience is an important goal to prevent symptoms of psychopathology. The Resilience Portfolio Model puts forward a framework to understand how different strengths (classified into three dimensions: regulatory, interpersonal, and meaning-making) can help people adapt and even thrive. Through this lens, the current study examines post-traumatic growth after victimization ...
Tópico(s): Posttraumatic Stress Disorder Research
2018 - SAGE Publishing | Journal of Interpersonal Violence
María Alonso de Leciñana, Michal Maciej Kawiorski, Á. Carrillo, Antonio Culebras, Á. García Pastor, Patricia Martínez‐Sánchez, A. Prieto, José Luis Caniego, José Carlos Méndez, Gustavo Zapata-Wainberg, Alicia de Felipe, Fernando Díaz‐Otero, Gerardo Ruiz‐Ares, R. Frutos, E. Bárcena‐Ruiz, Eduardo Fandiño, Begoña Marín, José Vivancos, Jaime Masjuán, Antonio Gil-Núñez, Exuperio Díez‐Tejedor, Blanca Fuentes,
Background and purpose The benefits of mechanical thrombectomy (MT) in basilar artery occlusions (BAO) have not been explored in recent clinical trials. We compared outcomes and procedural complications of MT in BAO with anterior circulation occlusions. Methods Data from the Madrid Stroke Network multicenter prospective registry were analyzed, including baseline characteristics, procedure times, procedural complications, symptomatic intracranial hemorrhage (SICH), modified Rankin Scale (mRS), and mortality ...
Tópico(s): Cerebral Venous Sinus Thrombosis
2016 - BMJ | Journal of NeuroInterventional Surgery
Javier Méndez, Gustavo Morales, Lea de Nascimento, Rüdiger Otto, Antonio Gallardo, José María Fernández‐Palacios,
The long-term effect of forest fires in the regeneration of Pinus canariensis was studied. Forest fires had little long-term effects on seed production, seedling germination and seedling mortality. The characteristics of different forest stands across the island had influence in some of the regeneration parameters studied. Despite the importance of forest regeneration dynamics after wildfires, little is known about its long-term evolution after a fire. We tested the effect of fire on the long-term ...
Tópico(s): Ecology and Vegetation Dynamics Studies
2015 - Springer Science+Business Media | Annals of Forest Science
Carmen Manta, Gabriela Peralta-Altier, Larissa Gioia, María F. Méndez, Gustavo Seoane, Karen Ovsejevi,
A thiol-β-cyclodextrin was synthesized by a simple and environmentally friendly three-step method comprising epoxy activation of β-cyclodextrin, thiosulfate-mediated oxirane opening, and further reduction of the S-alkyl thiosulfate to a thiol group. The final step was optimized by using thiopropyl-agarose, a solid phase reducing agent with many advantages over soluble ones. β-Cyclodextrin thiolation was confirmed by titration with a thiol-reactive reagent, NMR studies, and MALDI-TOF/TOF. Thiolated ...
Tópico(s): Enzyme Catalysis and Immobilization
2013 - American Chemical Society | Journal of Agricultural and Food Chemistry
... del Carmen Lopez Rodriguez, Juan Verdejo Paris,Arturo Mendez Ortiz, Gustavo S Pastelin Hernandez, Catalina Lomeli Estrada, J AntonioGonzalez- ...
Tópico(s): Clinical Nutrition and Gastroenterology
2012 - Elsevier BV | Revista de Gastroenterología de México
Mariela Risso, Mauro Mazzini, Santiago Kröger, Patricia Saenz‐Méndez, Gustavo Seoane, Daniela Gamenara,
Abstract Lipase-catalyzed transesterification was used as an efficient tool for the interconversion of β-ketoesters. Catalytic activity of commercial lipase B from Candida antarctica (Novozym 435) was evaluated in systems involving non activated acyl donors, and enhanced using microwave irradiation. Interestingly, the combination of CAL B in microwave irradiation worked excellent in solvent-free conditions, thus assuring a highly competitive and environment-friendly process with high yields (up to ...
Tópico(s): Multicomponent Synthesis of Heterocycles
2012 - Taylor & Francis | Green Chemistry Letters and Reviews
Maurício González-Jaurégui, Carolina Valdespino, Arturo Salame-Méndez, Gustavo Aguirre-León, Jaime Rendon-Von-Osten,
Tópico(s): Mercury impact and mitigation studies
2011 - Springer Science+Business Media | Archives of Environmental Contamination and Toxicology
Rafael A. Rivas-Vazquez, Cecilia Mendez, Gustavo Rey, Enrique Carrazana,
Mild cognitive impairment (MCI) is increasingly being conceptualized in the literature as a cognitive disturbance representing a transitional phase between normal aging and dementia. The operational definitions of MCI provide an opportunity for neuropsychologists to detect subtle deficit and monitor cognitive status sequentially in order to determine rate and degree of progression. More importantly, clinical and neuropsychological studies are needed that can better characterize which MCI patients ...
Tópico(s): Neurological Disorders and Treatments
2003 - Oxford University Press | Archives of Clinical Neuropsychology
José Alberto Méndez, Gustavo A. Abraham, Mar Fernández‐Gutiérrez, Blanca Vázquez‐Lasa, Julio San Román,
Abstract Partially biodegradable acrylic composites containing poly(methyl methacrylate)–poly(ϵ‐caprolactone) (PMMA/PCL) systems were prepared by mixing the corresponding PMMA/PCL beads (89:11, 86:14, 83:17, and 77:23 weight ratio) used as solid phase with methyl methacrylate (MMA) (liquid phase) in a solid/liquid ratio of 1.5:1. The physical and chemical microheterogeneity of these beads influenced significantly the curing parameters, because several aspects involved in the polymerization reaction ...
Tópico(s): Surgical Sutures and Adhesives
2002 - Wiley | Journal of Biomedical Materials Research
Hugo Cerecetto, Eduardo Días, Rossanna Di Maio, Mercedes González, Sandra Pacce, Patricia Saenz‐Méndez, Gustavo Seoane, Leopoldo Suescun, Álvaro W. Mombrú, Grisel Fernández, Marisa Lema, Juana Villalba,
As part of an ongoing program on the chemistry and biological activity of N-oxide-containing molecules, a number of novel 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline N,N'-dioxide derivatives were synthesized and evaluated for their herbicidal activity. Many of these compounds exhibited moderate to good herbicidal pre-emergence activity against Triticum aestivum. Dose−response studies were done on the more representative compounds (12, 20, and 26). The most active ...
Tópico(s): Analytical Chemistry and Chromatography
2000 - American Chemical Society | Journal of Agricultural and Food Chemistry
Hugo Cerecetto, Rossanna Di Maio, Mercedes González, Mariela Risso, Patricia Saenz‐Méndez, Gustavo Seoane, Ana Denicola, Gonzalo Peluffo, Celia Quijano, Claudio Olea‐Azar,
The syntheses of a new series of derivatives of 1,2,5-oxadiazole N-oxide, benzo[1,2-c]1,2,5-oxadiazole N-oxide, and quinoxaline di-N-oxide are described. In vitro antitrypanosomal activity of these compounds was tested against epimastigote forms of Trypanosoma cruzi. For the most effective drugs, derivatives IIIe and IIIf, the 50% inhibitory dose (ID50) was determined as well as their cytotoxicity against mammalian fibroblasts. Electrochemical studies and ESR spectroscopy show that the highest activities ...
Tópico(s): Free Radicals and Antioxidants
1999 - American Chemical Society | Journal of Medicinal Chemistry
C. Rojas, Susana Cadenas, A. Herrero, J. L. Fernández Méndez, Gustavo Barja,
The effect of acute endotoxin-induced septic shock on myocardium oxidative stress after low or high vitamin C and/or E dietary supplementation was studied in guinea pigs, laboratory animals which, like humans, do not have capacity for ascorbate synthesis. Neither the antioxidant enzymes or GSH were modified by endotoxin and vitamin treatments. Vitamin E showed a strong capacity to protect the myocardium against both enzymatic and non-enzymatic lipid peroxidation even in the presence of endotoxin. ...
Tópico(s): Vitamin K Research Studies
1996 - Elsevier BV | Life Sciences
Alexis K. Noriega, Alexis Tirado, Cecilia Méndez, Gustavo Marroquín, Jorge Ancheyta,
The generation of reliable experimental data in any experimental scale requires proper procedures not only for the reaction step but also for the feed preparation, separation, and characterization of products as well as calculations of conversion and product yields. Batch reactor is the most used experimental setup for carrying out exploratory studies for catalyst screening and development. This work is focused on describing and discussing a step-by-step methodology for conducting experiments for ...
Tópico(s): Catalysis for Biomass Conversion
2020 - Elsevier BV | Chinese Journal of Chemical Engineering
Luis Bernal–González, H.J. Cabana-Méndez, Gustavo A. Muñoz-Fernández, Juan B. Seoane‐Sepúlveda,
If $V$ stands for a subspace of $\mathcal {C}(\mathbb {R})$ such that every nonzero function in $V$ attains its maximum at one (and only one) point, then we prove that $\mathrm {dim}(V) \le 2$. This provides the final answer to a lineability problem posed by Vladimir I. Gurariy in 2003. Moreover, we generalize the previous result in the following terms: If $m \in \mathbb {N}$ and $V_m$ stands for a subspace of $\mathcal {C}(\mathbb {R})$ such that every nonzero function in $V_m$ attains its maximum at $m$ (and only $m$) ...
Tópico(s): Mathematical Dynamics and Fractals
2019 - American Mathematical Society | Transactions of the American Mathematical Society
Rajiv Agarwal, Wanzhu Tu, Alfredo E. Farjat, Youssef M.K. Farag, Robert D. Toto, Sanjay Kaul, Robert Lawatscheck, K Rohwedder, Luís M. Ruilope, Peter Rossing, Bertram Pitt, Gerasimos Filippatos, Stefan D. Anker, George L. Bakris, Augusto Vallejos, Richard J. MacIsaac, Guntram Schernthaner, Pieter Gillard, Maria Eugênia Fernandes Canziani, Theodora Temelkova‐Kurktschiev, Ellen Burgess, Sheldon W. Tobe, Fernando González, Zhihong Liu, Andrés Ángelo Cadena Bonfanti, Carlos Jaramillo, Martin Prázný, Jorma Strand, Michel Marre, Roland E. Schmieder, Christoph Wanner, Pantelis Sarafidis, Juliana C.N. Chan, László Rosivall, Joseph A. Eustace, Ehud Grossman, Yoram Yagil, Giuseppe Remuzzi, Daisuke Koya, Takashi Wada, Magdalena Madero Rovalo, Ron T. Gansevoort, Adriaan Kooy, Trine Finnes, Froilan DeLeon, Janusz Gumprecht, Fernando Teixeira e Costa, Alexander Dreval, Anantharaman Vathsala, Aslam Amod, Sin Gon Kim, Byung‐Wan Lee, Julio Pascual Santos, Bengt-Olov Tengmark, Michel Burnier, Chien‐Te Lee, Sukit Yamwong, Ramazan Sarı, Kieran McCafferty, Borys Mankovsky, Sharon G. Adler, Linda F. Fried, Mark V. Williams, Tran Quang Khanh, Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Gloria Viñes, Alfredo Wassermann, Walter P. Abhayaratna, Shamasunder Acharya, Elif I. Ekinci, Darren Lee, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon D. Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich C. Prischl, G. Schernthaner, Harald Sourij, Martin Wiesholzer, Peter Doubel, W. Engelen, Pieter Gillard, Jean‐Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn M. Speeckaert, Koen Stas, Luc Van Gaal, Hilde Vanbelleghem, Daniela Antunes, Roberto Botelho, Cláudia Brito, Luís Henrique Santos Canani, Maria Eugênia Fernandes Canziani, Maria Cerqueira, Rogério de Paula, Freddy G. Eliaschewitz, Carlos Eduardo Poli‐de‐Figueiredo, Adriana Costa e Forti, Miguel Nasser Hissa, Maurilo Leite, Emerson de Lima, Irene L. Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pecoits‐Filho, Marcio Pereira, Evandro Portes, Dalton Bertolim Précoma, Rosângela Réa, Miguel C. Riella, João Eduardo Nunes Salles, Eduardo Vasconcellos, Sérgio Vencio, Paul E. Barré, Brian Carlson, James Conway, Serge Cournoyer, R Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Joanne Liutkus, François Madore, Valdemar Martinho, Giuseppe Mazza, Philip A. McFarlane, Dennis O’ Keefe, Sean D. Peterson, Daniel Schwartz, Daniel Shu, Andrew Steele, Guy Tellier, Karthik Tennankore, Sheldon W. Tobe, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, S. John Weisnagel, Igor Wilderman, Jean‐François Yale, Jorge Cobos, Juan Godoy, Fernando González, Sergio Lobos, Juan Carlos Palma, Juan Carlos Prieto, Eliana Reyes, Carmen Romero, Víctor Saavedra, Mario Vega, Ruifang Bu, Cai H, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Tianjun Guan, Chuan‐Ming Hao, Wen Huang, Fangfang Jiang, Minxiang Lei, Ling Li, Zhonghe Li, Xuemei Li, Jingmei Li, Yan Li, Xinling Liang, Bo Liang, Fang Liu, Yinghong Liu, Yuan-Tao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Ping Luo, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Lihua Wang, Guixia Wang, Jianqin Wang, Yangang Wang, Li Wang, Jiali Wei, Tianfeng Wu, Chao-Qing Wu, Xing Changying, Fei Xiong, Xudong Xu, Ning Xu, Tiekun Yan, Jinkui Yang, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Wenjing Zhao, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Dalong Zhu, Yongze Zhuang, Clara Arango, Sandra Barrera, Nelly Beltrán López, Diego Benitez, Guillermo Blanco, Andrés Cadena, Julián Coronel, Carlos Cure, Carlos Durán, Alexander Ariel Padrón González, Gustavo Guzmán, Eric Hernández, Jaime Ibarra, Carlos Jaramillo, Nicolás Jaramillo, William Kattah, Dora I. Molina, Gregorio Sánchez, Mónica Terront, Freddy Trujillo, Miguel Urina‐Triana, Ruben Vargas, Iván Villegas, Hernán Yupanqui, D Alferi, Michal Brada, Jiri Brezina, Petr Bucek, Tomáš Edelsberger, Drahomira Gulakova, J Zapletalová, Olga Hola, Lucie Hornova, Jana Houdova, Helena Hrmova, David Karásek, Sarka Kopecka, Richard Kovar, Eva Krčová, Jiří Kuchař, Vlasta Kutejova, H Lubanda, Ivo Matyasek, Magdaléna Mokrejšová, Libor Okenka, Martin Prázný, Jiri Pumprla,
In patients with chronic kidney disease (CKD) and type 2 diabetes (T2D), finerenone, a nonsteroidal mineralocorticoid receptor antagonist, reduces cardiovascular and kidney failure outcomes. Finerenone also lowers the urine albumin-to-creatinine ratio (UACR). Whether finerenone-induced change in UACR mediates cardiovascular and kidney failure outcomes is unknown.
American College of Physicians
Peter Rossing, Ellen Burgess, Rajiv Agarwal, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Luís M. Ruilope, Pieter Gillard, Richard J. MacIsaac, Julio Wainstein, Amer Joseph, Meike Brinker, Lothar Roessig, Charlie Scott, George L. Bakris, Augusto Vallejos, Richard J. MacIsaac, Guntram Schernthaner, Pieter Gillard, Maria Eugênia Fernandes Canziani, Theodora Temelkova‐Kurktschiev, Ellen Burgess, Sheldon W. Tobe, Fernando González, Zhihong Liu, Andrés Ángelo, Cadena Bonfanti, Carlos Jaramillo, Martin Prázný, Peter Rossing, Jorma Strand, Michel Marre, Roland E. Schmieder, Christoph Wanner, Pantelis Sarafidis, Juliana C.N. Chan, László Rosivall, Joseph A. Eustace, Ehud Grossman, Yoram Yagil, Giuseppe Remuzzi, Daisuke Koya, Takashi Wada, Magdalena Madero Rovalo, Ron T. Gansevoort, Adriaan Kooy, Trine Finnes, Froilan De Leon, Janusz Gumprecht, Fernando Teixeira e Costa, Alexander Dreval, Anantharaman Vathsala, Aslam Amod, Sin Gon Kim, Byung‐Wan Lee, Julio Pascual Santos, Bengt-Olov Tengmark, Michel Burnier, Chien‐Te Lee, Sukit Yamwong, Ramazan Sarı, Kieran McCafferty, Borys Mankovsky, Sharon G. Adler, Linda P. Fried, Robert Toto, Mark V. Williams, Tran Quang Khanh, Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Gloria Viñes, Alfredo Wassermann, Walter P. Abhayaratna, Shamasunder Acharya, Elif I. Ekinci, Darren Lee, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon D. Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich C. Prischl, G. Schernthaner, Harald Sourij, Martin Wiesholzer, Peter Doubel, W. Engelen, Jean‐Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn M. Speeckaert, Koen Stas, Luc Van Gaal, Hilde Vanbelleghem, Daniela Antunes, Roberto Botelho, Cláudia Brito, Luís Henrique Santos Canani, Maria Eugênia Fernandes Canziani, Maria Cerqueira, Rogério de Paula, Freddy G. Eliaschewitz, Carlos Eduardo Poli‐de‐Figueiredo, Adriana Costa e Forti, Miguel Nasser Hissa, Maurilo Leite, Emerson de Lima, Irene L. Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pecoits‐Filho, Marcio Pereira, Evandro Portes, Dalton Bertolim Précoma, Rosângela Réa, Miguel C. Riella, João Eduardo Nunes Salles, Eduardo Vasconcellos, Sérgio Vencio, Emiliya Apostolova, Radostina Boshnyashka, Ghassan Farah, Dimitar Georgiev, Valentina Gushterova, Neli Klyuchkova, Mariya Lucheva, Petya Manova, Dotska Minkova, Boyan Nonchev, Mariyana Pichmanova, Zhulieta Prakova, Rangel Rangelov, Rosen Rashkov, Pavel Stanchev, Bilyana Stoyanovska-Elencheva, Zhivko Tagarev, Theodora Temelkova-Kurktschieva, S Vasileva, Mariana Yoncheva-Mihaylova, Paul E. Barré, Brian Carlson, James Conway, Serge Cournoyer, R Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Joanne Liutkus, François Madore, Valdemar Martinho, Giuseppe Mazza, Philip A. McFarlane, Dennis D. O’Keefe, Sean Peterson, Daniel M. Schwartz, Daniel Shu, Andrew Steele, Guy Tellier, Karthik Tennankore, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, S. John Weisnagel, Igor Wilderman, Jean‐François Yale, Jorge Cobos, Juan Godoy, Sergio Lobos, Juan Carlos Palma, Juan Carlos Prieto, Eliana Reyes, Carmen Romero, Víctor Saavedra, Mario Vega, Ruifang Bu, Cai H, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Tianjun Guan, Chuan‐Ming Hao, Wen Huang, Fangfang Jiang, Minxiang Lei, Ling Li, Zhonghe Li, Xuemei Li, Jingmei Li, Yan Li, Xinling Liang, Bo Liang, Fang Liu, Yinghong Liu, Yuan-Tao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Ping Luo, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Lihua Wang, Guixia Wang, Jianqin Wang, Yangang Wang, Li Wang, Jiali Wei, Tianfeng Wu, Chao-Qing Wu, Xing Changying, Fei Xiong, Xudong Xu, Ning Xu, Tiekun Yan, Jin‐Kui Yang, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Wenjing Zhao, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Dalong Zhu, Yongze Zhuang, Clara Arango, Sandra Barrera, Nelly Beltrán López, Diego Benitez, Guillermo Blanco, Andrés Cadena, Julián Coronel, Carlos Cure, Carlos Durán, Alexander Ariel Padrón González, Gustavo Guzmán, Eric Hernández, Jaime Ibarra, Carlos Jaramillo, Nicolás Jaramillo, William Kattah, Dora I. Molina, Gregorio Sánchez, Mónica Terront, Freddy Trujillo, Miguel Urina‐Triana, Ruben Vargas, Iván Villegas, Hernán Yupanqui, D Alferi, Michal Brada,
Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) in the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease trial. We explored whether baseline HbA1c level and insulin treatment influenced outcomes.Patients with T2D, urine albumin-to-creatinine ratio (UACR) of 30-5,000 mg/g, estimated glomerular filtration rate (eGFR) of 25 to <75 mL/min/1.73 m2, and treated with optimized renin-angiotensin ...
American Diabetes Association
Peter Rossing, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Luís M. Ruilope, Andreas L. Birkenfeld, Janet B. McGill, Sylvia E. Rosas, Amer Joseph, Martin Gebel, Luke Roberts, Markus F. Scheerer, George L. Bakris, Rajiv Agarwal, Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Augusto Vallejos, Gloria Viñes, Alfredo Wassermann, Walter P. Abhayaratna, Shamasunder Acharya, Elif I. Ekinci, Darren Lee, Richard J. MacIsaac, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon D. Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Peter G. Colman, David Colquhoun, Chris Ellis, Kim Joshua, Eugenia Pedagogos, Paul Regal, Duncan J. Topliss, James Vandeleur, Johan Verjans, Gary Wittert, Katie-Jane Wynne, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich C. Prischl, G. Schernthaner, Harald Sourij, Martin Wiesholzer, Heinz Drexel, Rainer Oberbauer, Hans‐Robert Schönherr, Peter Doubel, W. Engelen, Pieter Gillard, Jean‐Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn M. Speeckaert, Koen Stas, Luc Van Gaal, Hilde Vanbelleghem, Francis Duyck, André Scheen, Daniela Antunes, Roberto Botelho, Cláudia Brito, Luís Henrique Santos Canani, Maria Eugênia Fernandes Canziani, Maria Cerqueira, Rogério de Paula, Freddy G. Eliaschewitz, Carlos Eduardo Poli‐de‐Figueiredo, Adriana Costa e Forti, Miguel Nasser Hissa, Maurilo Leite, Emerson de Lima, Irene L. Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pecoits‐Filho, Marcio Pereira, Evandro Portes, Dalton Bertolim Précoma, Rosângela Réa, Miguel C. Riella, João Eduardo Nunes Salles, Eduardo Vasconcellos, Sérgio Vencio, Marcelo Rodrigues Bacci, Lília Nigro Maia, Aline Sterque Villacorta, Emiliya Apostolova, Radostina Boshnyashka, Ghassan Farah, Dimitar Georgiev, Valentina Gushterova, Neli Klyuchkova, Mariya Lucheva, Petya Manova, Dotska Minkova, Boyan Nonchev, Mariyana Pichmanova, Zhulieta Prakova, Rangel Rangelov, Rosen Rashkov, Pavel Stanchev, Bilyana Stoyanovska-Elencheva, Zhivko Tagarev, Theodora Temelkova-Kurktschieva, S Vasileva, Mariana Yoncheva-Mihaylova, Angel Marinchev, Mariya Miteva, Paul E. Barré, Brian Carlson, James Conway, Serge Cournoyer, R Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Joanne Liutkus, François Madore, Valdemar Martinho, Giuseppe Mazza, Philip A. McFarlane, Dennis D. O’Keefe, Sean D. Peterson, Daniel Schwartz, Daniel Shu, Andrew Steele, Guy Tellier, Karthik Tennankore, Sheldon W. Tobe, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, S. John Weisnagel, Igor Wilderman, Jean‐François Yale, Fadia El Boreky, Alan Kelly, Lawrence A. Leiter, Ivor Teitelbaum, Jorge Cobos, Juan Godoy, Fernando González, Sergio Lobos, Juan Carlos Palma, Juan Carlos Prieto Dominguez, Eliana Reyes, Carmen Romero, Víctor Saavedra, Mario Vega, Marcelo Gabriel Medina, Paola Varleta, Ruifang Bu, Cai H, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Tianjun Guan, Chuan‐Ming Hao, Wen Huang, Fangfang Jiang, Minxiang Lei, Ling Li, Zhonghe Li, Xuemei Li, Jingmei Li, Yan Li, Xinling Liang, Bo Liang, Fang Liu, Yinghong Liu, Yuantao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Ping Luo, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Guixia Wang, Jianqin Wang, Yangang Wang, Li Wang, Jiali Wei, Tianfeng Wu, Chao-Qing Wu, Xing Changying, Fei Xiong, Xudong Xu, Ning Xu, Tiekun Yan, Jinkui Yang, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Wenjing Zhao, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Dalong Zhu, Yongze Zhuang, Yuming Du, Yi Fang, Weiying Guo, Sheng Jiang, Jian Kuang, Dongmei Li, Hongmei Li, Yinan Li, Yuxiu Li, Liu Jian, Yu Liu, Heng Miao, Wen Peng, Lihua Wang, Mingtong Xu, Liyong Zhong, Jun Zhu, Clara Arango, Sandra Barrera, Nelly Beltrán López, Diego Benitez, Guillermo Blanco, Andrés Cadena, Julián Coronel, Carlos Cure, Carlos E. Durán, Alexander Ariel Padrón González, Gustavo Guzmán, Eric Hernández, Jaime Ibarra, Carlos Jaramillo, Nicolás Jaramillo, William Kattah, Dora I. Molina, Gregorio Sánchez, Mónica Terront, Freddy Trujillo, Miguel Urina‐Triana, Ruben Vargas, Iván Villegas, Hernán Yupanqui, Édgar Arcos, Gustavo Aroca, Germán Barreto, Andrés Bermúdez, Rodrigo Botero, Tatiana Cárdenas, Wilmer Figueroa, Mónica Jaramillo,
Finerenone reduced the risk of kidney and cardiovascular events in people with chronic kidney disease (CKD) and type 2 diabetes in the FIDELIO-DKD and FIGARO-DKD phase 3 studies. Effects of finerenone on outcomes in patients taking sodium-glucose cotransporter 2 inhibitors (SGLT2is) were evaluated in a prespecified pooled analysis of these studies.Patients with type 2 diabetes and urine albumin-to-creatinine ratio (UACR) ≥30 to ≤5,000 mg/g and estimated glomerular filtration rate (eGFR) ≥25 mL/min/1.73 ...
American Diabetes Association
Nuseibah Al Qtaish, Idoia Gallego, Ilia Villate-Beitia, Myriam Sainz-Ramos, Gema Martı́nez, Cristina Soto-Sánchez, Eduardo Fernández, Patricia Gálvez-Martín, Tania B. López-Méndez, Gustavo Puras, José Luís Pedraz,
The aim was to evaluate relevant biophysic processes related to the physicochemical features and gene transfection mechanism when sphingolipids are incorporated into a cationic niosome formulation for non-viral gene delivery to central nervous system. For that, two formulations named niosphingosomes and niosomes devoid of sphingolipid extracts, as control, were developed by the oil-in water emulsion technique. Both formulations and the corresponding complexes, obtained upon the addition of the reporter ...
Tópico(s): RNA Interference and Gene Delivery
2021 - Elsevier BV | European Journal of Pharmaceutics and Biopharmaceutics
Dagmar Monett, José Alberto Méndez, Gustavo A. Abraham, Alberto Gallardo, Julio San Román,
Here we apply evolutionary techniques to the calculation of copolymerization reactivity ratios from an inverse problem perspective. To estimate monomer reactivity ratios, we take into account the main aspects of both inverse problems and evolutionary computation techniques. Copolymers of methyl methacrylate (MMA) and α-tocopheryl methacrylate (MVE) were prepared by free radical copolymerization in dioxane solution using 2,2′-azoisobutyronitrile as the initiator. The reactivity ratios were calculated ...
Tópico(s): Advanced Polymer Synthesis and Characterization
2002 - Wiley | Macromolecular Theory and Simulations
Sandra Luna‐Fineman, Guillermo Chantada, Amanda Alejos, Geraldina Amador, Margarita Barnoya, Mauricio Castellanos, Ligia Fú, Soad Fuentes‐Alabi, Verónica Girón, Marco A. Goenz, Carlos J Maldonado, Gustavo Méndez, Rosa A. Morales, Roberta Ortiz, Gissela Sanchez, Matthew W. Wilson, Carlos Rodríguez‐Galindo,
Treatment abandonment because of enucleation refusal is a limitation of improving outcomes for children with retinoblastoma in countries with limited resources. Furthermore, many children present with buphthalmos and a high risk of globe rupture during enucleation. To address these unique circumstances, the AHOPCA II protocol introduced neoadjuvant chemotherapy with delayed enucleation.Patients with advanced unilateral intraocular disease (International Retinoblastoma Staging System [IRSS] stage I) ...
Tópico(s): Ocular Disorders and Treatments
2019 - Lippincott Williams & Wilkins | Journal of Clinical Oncology
Lucía González-Madina, Juan Pablo Pacheco, Lilen Yema, Paula de Tezanos, Paula Levrini, J.M. Clemente-Juan, Carolina Crisci, Juan José Lagomarsino, Gustavo Méndez, Claudia Fosalba, Guillermo Goyenola, Néstor Mazzeo,
Tópico(s): Aquatic Ecosystems and Biodiversity
2018 - Springer Science+Business Media | Hydrobiologia
Alp Ozpinar, Gustavo Méndez, Adib A. Abla,
Arteriovenous malformations (AVMs) are vascular deformities involving fistula formation of arterial to venous structures without an intervening capillary bed. Such anomalies can prove fatal as the high arterial flow can disrupt the integrity of venous walls, thus leading to dangerous sequelae such as hemorrhage. Diagnosis of these lesions in the central nervous system can often prove challenging as intracranial AVMs represent a heterogeneous vascular pathology with various presentations and symptomatology. ...
Tópico(s): Intracranial Aneurysms: Treatment and Complications
2017 - Elsevier BV | Handbook of clinical neurology
Carolina Crisci, Rafael Terra, Juan Pablo Pacheco, Badih Ghattas, Mario Pérez Bidegain, Guillermo Goyenola, Juan José Lagomarsino, Gustavo Méndez, Néstor Mazzeo,
A multi-model approach to predict phytoplankton biomass and composition was performed in a eutrophic Uruguayan shallow lake which is the second drinking water source of the country. We combined statistical (spectral analysis and Machine learning techniques) and physically based models to generate, for the first time in this system, a predictive tool of phytoplankton biomass (chlorophyll-a) and composition (morphology-based functional groups). The results, based on a 11-year time series, revealed two ...
Tópico(s): Marine and coastal ecosystems
2017 - Elsevier BV | Ecological Modelling
Jeremy Ciporen, Brandon Lucke‐Wold, Gustavo Méndez, William E. Cameron, Shirley McCartney,
Endoscopic surgical treatment of pituitary tumors, lateral invading tumors, or aneurysms requires surgeons to operate adjacent to the cavernous sinus. During these endoscopic endonasal procedures, the carotid artery is vulnerable to surgical injury at its genu. The objective of this simulation model was to evaluate trainees regarding management of a potentially life-threatening vascular injury. Cadaveric heads were prepared in accordance with the Oregon Health & Science University body donation program. ...
Tópico(s): Meningioma and schwannoma management
2016 - Elsevier BV | World Neurosurgery