Andrew Robson, Jane Dickson, James Landale, Sally Staples, Raymond Snoddy Media Editor, Stella Shamoon, Richard Whitehead, Helen Studd, Portia Colwell, Robert Cole, Catherine Riley, James Moore, Martin-Jenkins, Philip Barron, Rodney Tye, Jane MacQuitty, Peter Lansley, John Morgan, greg kadel, Salome Munuo, Mark Souster, Emma Haughton, Jonathan Lennie, John Waters, Philip Howard, John Bener, Martin Ross, Matthew Taylor, pauline mcleod, James Bone, Dean Hodgkin, Anne Gatti, Jack Barker, Elizabeth Judge, Sharon Linnard, Anne Robinson, Ben MacIntyre, Damian Whitworth and Ian Brodie, Clare Stewart, Peter Arden, Stewart Tendler and Ian Cobain, Giles Coren, Michael Holden, NS, Pat Gibson, Valerie Elliott Countryside Editor, David McVay, Stephen McClarence, Henry Harris, Steve Keenan, Stewart Tendler Crime Correspondent, Ann Scanlon, Dominic Walsh, Steve Bird, Ruth Gledhill, Alix Ramsay Tennis Correspondent, Jill Dupleix, Charles Taylor, david loftus, A. R. Chance, Peter Hughes, Robin Young, Damian Whitworth and Christopher Walker, Stephen Farrell, Oliver Wright, Andy Stephens, Julian Rollins, Bill Callaghan, Anthony G. Phillips, John Young, Keith Pike, David Hands, Charles Bremner, Philip Webster and Martin Fletcher, Mike Brewer Spread Eagie, Sarah Tucker, fiona hewitt, Greg Hurst, Mark Court, Keith Haskell, Caroline Merrell Banking Correspondent, Colin Greenhalgh, Angela Jameson, Malcolm Smith, Geoff Harwood, I. H. Stout, Russell Kempson, Robert Cole City Correspondent, Mary Gold, Ed Potton, Jeremy Bremridge, Richard Cork, Alan Watson, Frankie Dettori. Weeding Photographer, Stephen Anderton, Sarah Johnson, Jim Waterworth, David Lister, Mark Atherton, Peter Reid, Rick Broadbent, Matt Dickinson Football Correspondent, Mark Henderson Science Correspondent, Ann Treneman, Andy Stephens Football Focus, Nick Potts, John Hopkins Golf Correspondent, Rob Wright, Adam Jones, Helen Vaughan-Jones, David Powell Athletics Correspondent, Raymond Keene, Vaughan Freeman, Steve Howey, Adam Sage, David L. Crosby, Lewis Smith, Clive Mathieson, Melanie Tringham and Mark Atherton, Colonel Margaret Hay's, Warren Bardley, Martin Fletcher and Philip Webster, Min Cooper, Caroline Merrell, Christopher Walker Chief Ireland Correspondent, Oliver Holt, Richard Owen, Helen Nugent, Sandra Parsons, Damian Whitworth, Joseph Palley, Marcel Berlins, Roger Boyes, Oliver August, AH, David Hands Rugby Correspondent, Tom Dart, Glen Owen, Alan Muir Wood, Nick Szczepanik, James Doran, Melissa Kite Political Correspondent, perou, Sally Varlow, Craig Lord, Paul Divine, Paul McCann Media Correspondent, VS, Matthew Parris, PB, Jennai Cox, Helen Truszkowski, Sue Hepworth, Mark Hodkinson, Gavin Hadland, Craig Clarke, Kenneth Gulleford, George Caulkin, Chris McGrath, Russell Jenkins, Caitlin Moran, Philip Webster and Martin Fletcher and Michael Evans Defence Editor, David Harding, Tim Wapshott, Jane Owen, Walter Gammie, Rosemary Cook, Ben MacIntyre, DC, Carl Hiaasen, Ian Brodie, Andrew Stilton, John Goodbody Sports News Correspondent, Tim Harlow, Gabriel Mojay, Philip Webster, Richard Miles, John Naish, Fraser Nelson, Annabelle Thorpe, Tim Jones, Martin Waller, Michael Horsnell, Chris Ayres, Fran Littlewood, James Jackson, Will Price, Nigel Hawkes Health Editor, Stoddart of Swindon, Dr Thomas Stuttaford, Jill Crawshaw, Richard Morrison, David Powell, Sam Kiley, Phil Myers, Tom Chesshyre, Bill Edgar, Valerie Grove, Neil Cooper, Alyson Rudd, Tom Baldwin Deputy Political Editor, SJ, John Phillips, Martin Miller, Susie Steiner, Roland Watson Chief Political Correspondent, max bell and roger sargent, Sally Patten Retail Correspondent, Patience Wheatcroft, Ian Stout, Christopher Irvine, Chloe Bryan-Brown, Susan Emmett,
... Attendance Table Card Games No Title Card Games Gustavo Poyet Team of the Month PTA PTA Ajusting ...
2000 - Gale Group | TDA
Amr Elsawy, Mohamed Abdel-Mottaleb, Ibrahim-Osama Sayed, Dan Wen, Vatookarn Roongpoovapatr, Taher K. Eleiwa, Ahmed M. Sayed, Mariam Raheem, Gustavo Rosa Gameiro, Mohamed Abou Shousha,
To propose automatic segmentation algorithm (AUS) for corneal microlayers on optical coherence tomography (OCT) images.Eighty-two corneal OCT scans were obtained from 45 patients with normal and abnormal corneas. Three testing data sets totaling 75 OCT images were randomly selected. Initially, corneal epithelium and endothelium microlayers are estimated using a corneal mask and locally refined to obtain final segmentation. Flat-epithelium and flat-endothelium images are obtained and vertically projected ...
Tópico(s): Retinal and Macular Surgery
2019 - Association for Research in Vision and Ophthalmology | Translational Vision Science & Technology
Produção Nacional
Revisado por pares
Marina Alves Martins Siqueira, Matheus Belloni Torsani, Gustavo Rosa Gameiro, Lucas Albuquerque Chinelatto, Bruna Chacon Mikahil, Patrícia Zen Tempski, Mílton A. Martins,
Considering evidence on competency-based curricula and the benefits of volunteering, this study highlights innovative ideas to improve medical education during the COVID-19 pandemic. We investigated the motivations and perceptions of competencies developed as leadership and management skills in medical students who joined the COVID-19 Volunteering Program in a Brazilian medical school.
Tópico(s): Global Health and Surgery
2022 - BioMed Central | BMC Medical Education
Produção Nacional
Revisado por pares
Maria Clara Saad Menezes, Diego Vinicius Santinelli Pestana, Gustavo Rosa Gameiro, Luiz Fernando Ferraz da Silva, Ėlodie Baron, Jean‐Jacques Rouby, José Otávio Costa Auler Júnior,
Abstract The current pandemic of COVID-19 caused thousands of deaths and healthcare professionals struggle to properly manage infected patients. This review summarizes information about SARS-CoV-2 receptor binding dynamics and intricacies, lung autopsy findings, immune response patterns, evidence-based explanations for the immune response, and COVID-19-associated hypercoagulability.
Tópico(s): Long-Term Effects of COVID-19
2021 - BioMed Central | Critical Care
Produção Nacional
Revisado por pares
Gustavo Rosa Gameiro, Viktor Sinkunas, Gabriel Romero Liguori, José Otávio Costa Auler Júnior,
Health care has changed since the decline in mortality caused by infectious diseases as well as chronic and noncontagious diseases, with a direct impact on the cost of public health and individual health care.We must now transition from traditional reactive medicine based on symptoms, diagnosis and treatment to a system that targets the disease before it occurs and, if it cannot be avoided, treats the disease in a personalized manner.Precision Medicine is that new way of thinking about medicine. ...
Tópico(s): Genetics, Bioinformatics, and Biomedical Research
2018 - Elsevier BV | Clinics
Produção Nacional
Revisado por pares
Gustavo Rosa Gentil Andrade, Bartira Mendes Gorgulho, Paulo A. Lotufo, Isabela M. Benseñor, Dirce Maria Lobo Marchioni,
Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saúde do Adulto—ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35–74 years. Dietary data was collected using a previously validated food frequency questionnaire. ...
Tópico(s): Heavy Metal Exposure and Toxicity
2018 - Multidisciplinary Digital Publishing Institute | Nutrients
Gustavo Rosa Gameiro, Pedro Monsalve, Iuri Golubev, Lori M. Ventura, Vittorio Porciatti,
Purpose: The water drinking test (WDT) is currently used to temporarily elevate intraocular pressure (IOP) and predict peak IOP in glaucoma. This study investigates neurovascular changes associated with WDT in normal subjects. Methods: The effect of WDT (1 L in 5 min) on IOP, mean brachial blood pressure, heart rate, and pattern electroretinogram was assessed within the next hour in 16 healthy subjects (mean age: 33.5±7.9 y). As a control, testing was repeated in the same subjects without WDT 1 week ...
Tópico(s): Retinal Imaging and Analysis
2018 - Lippincott Williams & Wilkins | Journal of Glaucoma
Produção Nacional
Mariana Rillo Sato, A. Ramos, Carolina Costa Silva, Gustavo Rosa Gameiro, Camila Scatena,
Grupos de artistas profissionais ou voluntários têm-se formado com o intuito de visitar, como palhaços, pacientes em hospitais ao redor do mundo, fazendo uso do humor como ferramenta a favor do cuidado e do processo de recuperação. Há poucos estudos relacionados ao tema na literatura científica. Assim, a construção de um campo teórico capaz de subsidiar essas atuações ainda é incipiente. Realizamos, portanto, uma revisão bibliográfica, a partir de 33 artigos, sobre a atuação de diferentes grupos ...
Tópico(s): Language Acquisition and Education
2015 - Faculdade de Medicina de Botucatu (Unesp) | Interface - Comunicação Saúde Educação
Produção Nacional
Revisado por pares
Midori H. Osaki, Tammy H. Osaki, Denny Marcos Garcia, Teissy Osaki, Gustavo Rosa Gameiro, Rubens Belfort, Antônio Augusto Velasco e Cruz,
Tópico(s): Facial Nerve Paralysis Treatment and Research
2019 - Springer Science+Business Media | Graefe s Archive for Clinical and Experimental Ophthalmology
Cristiane Machado Mengatto, Gustavo Rosa Gameiro, Mario Brondani, CP Owen, Michael MacEntee,
The aim of this randomized clinical trial was to test the hypothesis that there are no statistically significant differences after 3 and 6 months in masticatory performance or chewing ability of people with new complete dentures made by an abbreviated or a conventional technique.The trial included 20 edentulous participants at a dental school in Brazil assigned randomly to receive dentures made by either a conventional technique involving six clinical sessions or by an abbreviated technique involving ...
Tópico(s): Dysphagia Assessment and Management
2017 - Quintessence Publishing Company | The International Journal of Prosthodontics
Produção Nacional
Revisado por pares
Mariani Carla Prudente Batista, Eliane de Fatima Duarte, Michele Delarmelina dos Reis Borba, Emilie Zingler, João Mangussi‐Gomes, Beatriz Taynara Araújo dos Santos, Olívia Laquis de Moraes, Sylvia Asaka Yamashita Hayashida, Edmund Chada Baracat, Francisco de Assis da Rocha Neves, Gustavo Arantes Rosa Maciel, Tânia A.S.S. Bachega, Gustavo Barcelos Barra, Adriana Lofrano‐Porto,
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder, of multifactorial etiology, which affects 6-10% of women of reproductive age. It is considered the leading cause of anovulatory infertility, menstrual disorders and hyperandrogenism in this population. The genetic basis of PCOS is still largely unknown despite significant family clustering; determining its mode of inheritance is particularly difficult given the heterogenic presentation of the disease.130 Brazilian women, aged 14-42 ...
Tópico(s): Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
2014 - Elsevier BV | Gene
Produção Nacional
Gustavo Rosa Gameiro, Isabela Pasqualini Minguini, Tania C. T. Ferraz Alves,
The prevalence of major depressive episode in the elderly leads to impairment on several aspects of daily life, including life quality, morbid - mortality and increases rates of suicide risks. Stress and life events are frequent triggers of depressive episode in elderly. The present review aimed to explore the aspects related to the onset of depression in old age, focusing on psychosocial and stress. In order to achieve that, we systematically reviewed papers published in the Medline database from ...
Tópico(s): Health disparities and outcomes
2014 - UNIVERSIDADE DE SÃO PAULO | Revista de Medicina
Produção Nacional
Revisado por pares
Mônica M. França, Mariana F.A. Funari, Antônio Marcondes Lerário, Mariza Gerdulo Santos, Mirian Yumie Nishi, Sorahia Domenice, Daniela Moraes, Everlayny F. Costalonga, Gustavo Arantes Rosa Maciel, Andréa Trevas Maciel‐Guerra, Gil Guerra‐Júnior, Berenice B. Mendonça,
Primary ovarian insufficiency (POI) is a heterogeneous disorder associated with several genes. The majority of cases are still unsolved. Our aim was to identify the molecular diagnosis of a Brazilian cohort with POI. Genetic analysis was performed using a customized panel of targeted massively parallel sequencing (TMPS) and the candidate variants were confirmed by Sanger sequencing. Additional copy number variation (CNV) analysis of TMPS samples was performed by CONTRA. Fifty women with POI (29 primary ...
Tópico(s): Ovarian function and disorders
2020 - Public Library of Science | PLoS ONE
Produção Nacional
Revisado por pares
Bruno Ramalho de Carvalho, Ionara Diniz Evangelista Santos Barcelos, Sebastião Freitas de Medeiros, Cristina Laguna Benetti‐Pinto, Daniela Angerame Yela, Andréa Prestes Nácul, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Ana Carolina Japur de Sá Rosa e Silva, Laura Olinda Bregieiro Fernandes Costa,
Abstract Considering that myths and misconceptions regarding natural procreation spread rapidly in the era of easy access to information and to social networks, adequate counseling about natural fertility and spontaneous conception should be encouraged in any kind of health assistance. Despite the fact that there is no strong-powered evidence about any of the aspects related to natural fertility, literature on how to increase the chances of a spontaneous pregnancy is available. In the present article, ...
Tópico(s): Ovarian function and disorders
2019 - Thieme Medical Publishers (Germany) | Revista Brasileira Ginecologia e Obstetrícia
Produção Nacional
Revisado por pares
Ana Carolina Firmino Murgel, Ricardo Santos Simões, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Edmund Chada Baracat,
ABSTRACT Introduction Sexual dysfunction occurs in any phase of sexual performance or any period of the sexual response cycle, and polycystic ovary syndrome (PCOS) affects self-image with repercussions on sexuality. Aim To evaluate sexual dysfunction in women with PCOS. Methods A systematic review was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. The primary databases MEDLINE, EMBASE, Cochrane, and Lilacs were accessed using specific terms. There was ...
Tópico(s): Menstrual Health and Disorders
2019 - Elsevier BV | The Journal of Sexual Medicine
Produção Nacional
Revisado por pares
Cristian Augusto Ostjen, Carlos Gustavo Sakuno Rosa, Renata Minuzzo Hartmann, Elizângela Gonçalves Schemitt, Josieli Raskopf Colares, Norma Possa Marroni,
In recent decades, the number of people who practice sports has grown exponentially, increasing the number of muscular injuries. Trauma injury occurs when the muscle is exposed to a sudden compression force. Melatonin (MLT) has often been cited in the literature as a potent antioxidant and anti-inflammatory agent. This study was designed to evaluate MLT action on muscle tissue in Wistar rats in an experimental model of muscle trauma. Twenty-eight Wistar rats were used, divided into four groups: CO ( ...
Tópico(s): Medical and Biological Ozone Research
2018 - Elsevier BV | Experimental and Molecular Pathology
Produção Nacional
Revisado por pares
Luísa Pinheiro Pimenta Neves, Rodrigo Rodrigues Marcondes, Giovana De Nardo Maffazioli, Ricardo Santos Simões, Gustavo Arantes Rosa Maciel, José Maria Soares Júnior, Edmund Chada Baracat,
Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder, which affects 5–17% of reproductive age women and is often associated with obesity and metabolic impairment. Common treatment strategies are based on exercise, diet and nutrient supplementation since PCOS is often linked with obesity and metabolic impairment. Studies have recommended that nutrition is a key factor in the health maintenance of women with PCOS, however, little is known about the subject in the context of such a disease. ...
Tópico(s): Growth Hormone and Insulin-like Growth Factors
2020 - Informa | Gynecological Endocrinology
Produção Nacional
Revisado por pares
Giovana De Nardo Maffazioli, Caroline Panone Lopes, Vanessa Heinrich‐Oliveira, Rogerio A. Løbo, Sylvia Asaka Yamashita Hayashida, José Maria Soares Júnior, Gustavo Arantes Rosa Maciel, Edmund Chada Baracat,
Abstract Objective To describe the prevalence of metabolic disturbances in a large cohort of women with polycystic ovary syndrome (PCOS) in southeastern Brazil and to compare the findings with other cohorts of Brazilian women with PCOS. Methods A retrospective study analyzing clinical and laboratory data of 462 women with PCOS treated at an outpatient clinic in a tertiary hospital in southeastern Brazil. Prevalence of insulin resistance, glucose intolerance, type 2 diabetes, dyslipidemia, central ...
Tópico(s): Reproductive Biology and Fertility
2020 - Elsevier BV | International Journal of Gynecology & Obstetrics
Produção Nacional
Revisado por pares
Gilberto Nepomuceno Salvador, Cecília Gontijo Leal, Gabriel Lourenço Brejão, Tiago Casarim Pessali, Carlos Bernardo Mascarenhas Alves, Gustavo Ribeiro Rosa, Raphael Ligeiro, Luciano Fogaça de Assis Montag,
The number of disasters involving tailings storage facilities has increased in Brazil. Only in the last six years, there have been six disasters involving this type of structure. Despite the vast socio-environmental impacts, little has been done to mitigate the damage caused. The negligence of mining companies and the lack of efficient management approaches at river basin-level have greatly hampered efforts for environmental recovery. In addition, although Brazil has signed the 2030 Agenda for Sustainable ...
Tópico(s): Mining and Resource Management
2020 - Elsevier BV | Perspectives in Ecology and Conservation
Produção Nacional
Revisado por pares
Sebastião Freitas de Medeiros, Matheus Antônio Souto de Medeiros, Bruna Barcelo Barbosa, Márcia Marly Winck Yamamoto, Gustavo Arantes Rosa Maciel,
Tópico(s): Lipid metabolism and disorders
2020 - Springer Science+Business Media | Archives of Gynecology and Obstetrics
Produção Nacional
Caio Robledo D’Angioli Costa Quaio, Caroline Mônaco Moreira, Gil Monteiro Novo‐Filho, Patricia Rossi Sacramento‐Bobotis, Michele Groenner Penna, Sandro Félix Perazzio, Aurélio Pimenta Dutra, Rafael Alves da Silva, Monize Nakamoto Provisor Santos, Vanessa Yurie Nozaki de Arruda, Vanessa Galdeno Freitas, Vinícius Ceola Pereira, Maria Carolina Tostes Pintão, Alexandre Ricardo dos Santos Fornari, Ana Lígia Buzolin, Andre Yuji Oku, Matheus Carvalho Bürger, Rodrigo Fernandes Ramalho, David Santos Marco Antônio, Elisa Napolitano Ferreira, Otavio Jose Eulalio Pereira, Vanessa Dionisio Cantagalli, Ana Carolina Gomes Trindade, Rafaela Rogerio Floriano de Sousa, Cintia Reys Furuzawa, Fernanda Verzini, Shirley Dezan Matalhana, Naiade Romano, Daniele Paixão, Caroline Olivati, Gustavo Marquezani Spolador, Gustavo Arantes Rosa Maciel, Viviane Z. Rocha, Javier Miguelez, Mário Henrique Burlacchini de Carvalho, Alexandre Wagner Silva de Souza, Luís Eduardo Coelho Andrade, Maria de Lourdes Chauffaille, Aline dos Santos Borgo Perazzio, Ana Lúcia Catelani, Miguel Mitne‐Neto, Chong Ae Kim, Wagner Antonio da Rosa Baratela,
Abstract Rare diseases comprise a diverse group of conditions, most of which involve genetic causes. We describe the variable spectrum of findings and clinical impacts of exome sequencing (ES) in a cohort of 500 patients with rare diseases. In total, 164 primary findings were reported in 158 patients, representing an overall diagnostic yield of 31.6%. Most of the findings (61.6%) corresponded to autosomal dominant conditions, followed by autosomal recessive (25.6%) and X‐linked (12.8%) conditions. These ...
Tópico(s): Genetic factors in colorectal cancer
2020 - Wiley | American Journal of Medical Genetics Part C Seminars in Medical Genetics
Produção Nacional
Revisado por pares
Renato Tomioka, Gabriela R. V. Ferreira, Nádia Emi Aikawa, Gustavo Arantes Rosa Maciel, P. Serafini, Adriana Maluf Elias Sallum, Lúcia Maria Arruda Campos, Claudia Goldestein-Schainberg, Eloísa Bonfá, Clóvis A. Silva,
Tópico(s): Ovarian function and disorders
2018 - Springer Science+Business Media | Clinical Rheumatology
Produção Nacional
Revisado por pares
Larissa Gomes, Marina Cunha-Silva, Raiane P Crespo, Carolina Ramos, Luciana Ribeiro Montenegro, Ana Pinheiro Machado Canton, Melissa Lees, Helen Spoudeas, Andrew Dauber, Delanie B. Macedo, Danielle S. Bessa, Gustavo Arantes Rosa Maciel, Edmund Chada Baracat, Alexander A.L. Jorge, Berenice B. Mendonça, Vinícius Nahime Brito, Ana Cláudia Latronico,
Delta-like homolog 1 (DLK1), also called preadipocyte factor 1, prevents adipocyte differentiation and has been considered a molecular gatekeeper of adipogenesis. A DLK1 complex genomic defect was identified in five women from a single family with central precocious puberty (CPP) and increased body fat percentage.We studied 60 female patients with a diagnosis of CPP or history of precocious menarche. Thirty-one of them reported a family history of precocious puberty. DLK1 DNA sequencing was performed ...
Tópico(s): Kruppel-like factors research
2018 - Oxford University Press | The Journal of Clinical Endocrinology & Metabolism
Produção Nacional
Revisado por pares
Mônica M. França, Mirian Yumie Nishi, Mariana F.A. Funari, Antônio Marcondes Lerário, Edmund Chada Baracat, Sylvia Asaka Yamashita Hayashida, Gustavo Arantes Rosa Maciel, Alexander A.L. Jorge, Berenice B. Mendonça,
Primary ovarian insufficiency (POI) is characterized by primary or secondary amenorrhea , infertility, low estradiol levels, and increased gonadotropin levels. Most cases of POI remain unsolved even after exhaustive investigation. Here, we performed a targeted massively parallel sequencing to identify the genetic diagnosis of primary ovarian insufficiency (POI) in a Brazilian patient. An adopted 21-year-old Brazilian woman with isolated POI was selected. A custom SureSelect XT DNA target enrichment ...
Tópico(s): BRCA gene mutations in cancer
2018 - Elsevier BV | European Journal of Medical Genetics
Produção Nacional
Revisado por pares
Gabriela R. V. Ferreira, Renato Tomioka, Nádia Emi Aikawa, Elaine Pires Leon, Gustavo Arantes Rosa Maciel, P. Serafini, Edmund Chada Baracat, Cláudia Goldenstein‐Schainberg, Rosa Maria Rodrigues Pereira, Eloísa Bonfá, Clóvis A. Silva,
Juvenile idiopathic arthritis (JIA) occurs during reproductive age, however, there are no systematic data regarding ovarian function in this disease.Twenty-eight post-pubertal JIA patients and age-matched 28 healthy controls were studied. Complete ovarian function was assessed during the early follicular phase of the menstrual cycle including anti-Müllerian hormone (AMH), estradiol, luteinizing hormone (LH), follicle-stimulating hormone (FSH) and antral follicle count (AFC) by ovarian ultrasound, and ...
Tópico(s): Pregnancy and Medication Impact
2018 - Oxford University Press | Modern Rheumatology
Produção Nacional
Revisado por pares
Álvaro Anzai, Rodrigo Rodrigues Marcondes, Thiago Hideki Gonçalves, Kátia Cândido Carvalho, Manuel de Jesus Simões, Natália Garcia, José Maria Soares Júnior, Vasantha Padmanabhan, Edmund Chada Baracat, Ismael Dale Cotrim Guerreiro da Silva, Gustavo Arantes Rosa Maciel,
Abstract Polycystic ovary syndrome (PCOS) is frequently associated with non-alcoholic fatty liver disease (NAFLD), but the mechanisms involved in the development of NAFLD in PCOS are not well known. We investigated histological changes and metabolomic profile in the liver of rat models of PCOS phenotype induced by testosterone or estradiol. Two-day old female rats received sc injections of 1.25 mg testosterone propionate (Testos; n = 10), 0.5 mg estradiol benzoate (E2; n = 10), or vehicle (control group, ...
Tópico(s): Adipose Tissue and Metabolism
2017 - Nature Portfolio | Scientific Reports
Produção Nacional
Revisado por pares
Gustavo Ribeiro Rosa, Gilberto Nepomuceno Salvador, Andréa Bialetzki, Gilmar Bastos Santos,
Abstract Flow‐dependent fish specialists require specific conditions for reproduction, so the success and reproductive intensity of these animals are determined by the flood regime. Thus, this study investigated the spatial and temporal reproductive patterns of fish, especially migratory Prochilodu s species (flow‐dependent specialists) in an unusual period of low flow in the Pará River sub‐basin, one of the main tributaries of the upper São Francisco River. For this, ichthyoplankton collections ...
Tópico(s): Fish Biology and Ecology Studies
2017 - Wiley | River Research and Applications
Produção Nacional
Revisado por pares
Jessica L. Chan, Sujata Kar, Eszter Vanky, Laure Morin‐Papunen, Terhi Piltonen, Johanna Puurunen, Juha S. Tapanainen, Gustavo Arantes Rosa Maciel, Sylvia Asaka Yamashita Hayashida, José Maria Soares Júnior, Edmund Chada Baracat, Jan Roar Mellembakken, Anuja Dokras,
Background Polycystic ovary syndrome is a heterogeneous disorder and its presentation varies with race and ethnicity. Reproductive-age women with polycystic ovary syndrome are at increased risk of metabolic syndrome; however, it is not clear if prevalence of metabolic syndrome and clustering of its components differs based on race and ethnicity. Moreover, the majority of these women do not undergo routine screening for metabolic syndrome. Objective We sought to compare the prevalence of metabolic ...
Tópico(s): Gestational Diabetes Research and Management
2017 - Elsevier BV | American Journal of Obstetrics and Gynecology
Produção Nacional
Revisado por pares
Lia Cruz Vaz da Costa Damásio, José Maria Soares Júnior, Jairo Iavelberg, Gustavo Arantes Rosa Maciel, Manuel de Jesus Simões, Ricardo Santos Simões, Eduardo Vieira da Motta, Maria Cândida Pinheiro Baracat, Edmund Chada Baracat,
Ovarian autotransplantation has shown increasing promise as a clinical method for the preservation of fertility and hormonal function. However, information regarding the success rate of this type of transplantation is limited. We hypothesized that results vary according to the site of the ovarian transplantation. To test this hypothesis, fresh or cryopreserved ovarian strips were autotransplanted to orthotopic or heterotopic sites. The strips were later collected, and the morphology and expression ...
Tópico(s): Pluripotent Stem Cells Research
2016 - BioMed Central | Journal of Ovarian Research
Produção Nacional
Revisado por pares
Rodrigo Rodrigues Marcondes, Kátia Cândido Carvalho, Daniele Coelho Duarte, Natália Garcia, Vinícius Cestari do Amaral, Manuel de Jesus Simões, E.G. Lo Turco, José Maria Soares Júnior, Edmund Chada Baracat, Gustavo Arantes Rosa Maciel,
Exposure to an excess of androgen or estrogen can induce changes in reproductive function in adult animals that resemble polycystic ovary syndrome in humans. However, considerable differences exist among several types of animal models. Little is known about the molecular features of steroidogenesis and folliculogenesis in the ovaries of rats exposed to different sex steroids as neonates. Here, we evaluated the impact of androgen and estrogen exposure on the ovaries of adult female rats during their ...
Tópico(s): Sperm and Testicular Function
2015 - Elsevier BV | General and Comparative Endocrinology